LDHA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.80870832
2IMP biosynthetic process (GO:0006188)5.12594957
3Golgi transport vesicle coating (GO:0048200)4.85165655
4COPI coating of Golgi vesicle (GO:0048205)4.85165655
5nucleobase biosynthetic process (GO:0046112)4.82556742
6DNA strand elongation involved in DNA replication (GO:0006271)4.74703610
7folic acid-containing compound biosynthetic process (GO:0009396)4.71802110
8IMP metabolic process (GO:0046040)4.56277736
9DNA strand elongation (GO:0022616)4.48898606
10DNA replication initiation (GO:0006270)4.37410133
11protein maturation by protein folding (GO:0022417)4.34701340
12formation of translation preinitiation complex (GO:0001731)4.34017758
13purine nucleobase biosynthetic process (GO:0009113)4.33393099
14protein localization to kinetochore (GO:0034501)4.14184299
15mitotic nuclear envelope disassembly (GO:0007077)4.09087002
16telomere maintenance via semi-conservative replication (GO:0032201)4.06395574
17regulation of mitotic spindle organization (GO:0060236)4.03217137
18ribosomal small subunit assembly (GO:0000028)3.98728849
19peptidyl-proline hydroxylation (GO:0019511)3.96564707
20proteasome assembly (GO:0043248)3.91147218
21maturation of SSU-rRNA (GO:0030490)3.79266467
22nuclear envelope disassembly (GO:0051081)3.77167057
23membrane disassembly (GO:0030397)3.77167057
244-hydroxyproline metabolic process (GO:0019471)3.75959608
25nuclear pore organization (GO:0006999)3.75339700
26establishment of integrated proviral latency (GO:0075713)3.74788463
27protein hydroxylation (GO:0018126)3.72430332
28regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.67611945
29regulation of translational fidelity (GO:0006450)3.57101238
30telomere maintenance via recombination (GO:0000722)3.55542349
31ribosome assembly (GO:0042255)3.53043476
32maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.51556803
33DNA replication-dependent nucleosome assembly (GO:0006335)3.51139403
34DNA replication-dependent nucleosome organization (GO:0034723)3.51139403
35protein localization to chromosome, centromeric region (GO:0071459)3.48500190
36nuclear pore complex assembly (GO:0051292)3.45894977
37viral transcription (GO:0019083)3.39446478
38mitotic recombination (GO:0006312)3.37388823
39translational termination (GO:0006415)3.37087709
40DNA duplex unwinding (GO:0032508)3.35003212
41translational elongation (GO:0006414)3.34980368
42DNA geometric change (GO:0032392)3.33665171
43ribosome biogenesis (GO:0042254)3.33144527
44telomere maintenance via telomere lengthening (GO:0010833)3.28413195
45pore complex assembly (GO:0046931)3.27342344
46mitotic metaphase plate congression (GO:0007080)3.25270579
47DNA deamination (GO:0045006)3.23604246
48pentose-phosphate shunt (GO:0006098)3.21275515
49ribosomal large subunit biogenesis (GO:0042273)3.18801337
50translational initiation (GO:0006413)3.18521013
51spliceosomal snRNP assembly (GO:0000387)3.18334168
52regulation of translational termination (GO:0006449)3.14644909
53ribonucleoprotein complex biogenesis (GO:0022613)3.13507266
54mitotic chromosome condensation (GO:0007076)3.12558773
55heterochromatin organization (GO:0070828)3.12161437
56nucleotide-excision repair, DNA gap filling (GO:0006297)3.11094548
57nucleotide-sugar biosynthetic process (GO:0009226)3.09650916
58regulation of cellular amino acid metabolic process (GO:0006521)3.08734936
59positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.07944984
60COPII vesicle coating (GO:0048208)3.07576573
61protein retention in ER lumen (GO:0006621)3.07054898
62membrane raft organization (GO:0031579)3.05196287
63protein complex localization (GO:0031503)3.04021717
64tetrahydrofolate metabolic process (GO:0046653)3.02281541
65signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.02246121
66intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.02246121
67DNA replication checkpoint (GO:0000076)3.01235807
68regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.01055722
69CENP-A containing nucleosome assembly (GO:0034080)2.99610250
70DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.98641123
71peptidyl-arginine omega-N-methylation (GO:0035247)2.98073860
72signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.97301897
73signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.97301897
74signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.97301897
75* glycolytic process (GO:0006096)2.96791632
76chromatin remodeling at centromere (GO:0031055)2.95987348
77signal transduction involved in DNA damage checkpoint (GO:0072422)2.95021284
78signal transduction involved in DNA integrity checkpoint (GO:0072401)2.95021284
79positive regulation of ligase activity (GO:0051351)2.92812851
80nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.92013354
81nuclear envelope reassembly (GO:0031468)2.92001362
82mitotic nuclear envelope reassembly (GO:0007084)2.92001362
83metaphase plate congression (GO:0051310)2.88002004
84ventricular cardiac muscle cell development (GO:0055015)2.87930371
85signal transduction involved in cell cycle checkpoint (GO:0072395)2.87425580
86pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.86825500
87tRNA aminoacylation for protein translation (GO:0006418)2.86503201
88regulation of ubiquitin-protein transferase activity (GO:0051438)2.86181430
89deoxyribonucleotide biosynthetic process (GO:0009263)2.83754504
90gluconeogenesis (GO:0006094)2.83728428
91regulation of protein heterodimerization activity (GO:0043497)2.83471532
92negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.83056302
93proline biosynthetic process (GO:0006561)2.82987420
94postreplication repair (GO:0006301)2.81764142
95nuclear envelope organization (GO:0006998)2.81668264
96NADPH regeneration (GO:0006740)2.81224685
97amino acid activation (GO:0043038)2.79560124
98tRNA aminoacylation (GO:0043039)2.79560124
99folic acid metabolic process (GO:0046655)2.79392092
100rRNA processing (GO:0006364)2.78786083
101translesion synthesis (GO:0019985)2.77520953
102mitotic sister chromatid segregation (GO:0000070)2.76734138
103tricarboxylic acid cycle (GO:0006099)2.76651520
104ribosomal small subunit biogenesis (GO:0042274)2.76598588
105anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.76237065
106pseudouridine synthesis (GO:0001522)2.74379423
107regulation of ligase activity (GO:0051340)2.74329035
108establishment of viral latency (GO:0019043)2.74131733
109negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.74054765
110protein heterotetramerization (GO:0051290)2.73928558
111pteridine-containing compound biosynthetic process (GO:0042559)2.73459940
112AMP metabolic process (GO:0046033)2.73205223
113regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.72787658
114DNA replication-independent nucleosome assembly (GO:0006336)2.72466409
115DNA replication-independent nucleosome organization (GO:0034724)2.72466409
116cellular protein complex disassembly (GO:0043624)2.71461459
117DNA conformation change (GO:0071103)2.70602763
118regulation of histone H3-K9 methylation (GO:0051570)2.70494040
119G1/S transition of mitotic cell cycle (GO:0000082)2.69592566
120cell cycle G1/S phase transition (GO:0044843)2.69592566
121viral life cycle (GO:0019058)2.69333905
122SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.69105252
123* pyruvate metabolic process (GO:0006090)2.68392505
124rRNA metabolic process (GO:0016072)2.68101834
125cullin deneddylation (GO:0010388)2.67934545
126nucleobase-containing small molecule interconversion (GO:0015949)2.67527788
127positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.67516052
128glucose 6-phosphate metabolic process (GO:0051156)2.67004299
129hexose biosynthetic process (GO:0019319)2.66971546
130spindle checkpoint (GO:0031577)2.66677060
131establishment of chromosome localization (GO:0051303)2.65894837
132chaperone-mediated protein complex assembly (GO:0051131)2.65790295
133base-excision repair (GO:0006284)2.65544527
134chromosome condensation (GO:0030261)2.62309670
135pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.62023812
136sister chromatid segregation (GO:0000819)2.61914450
137T cell apoptotic process (GO:0070231)2.61192627
138regulation of metalloenzyme activity (GO:0048552)2.60722798
139regulation of posttranscriptional gene silencing (GO:0060147)2.60578928
140regulation of gene silencing by miRNA (GO:0060964)2.60578928
141regulation of gene silencing by RNA (GO:0060966)2.60578928
142negative regulation of ligase activity (GO:0051352)2.60575420
143negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.60575420
144regulation of spindle organization (GO:0090224)2.60176806
145regulation of chromosome segregation (GO:0051983)2.57580313
146mitotic spindle checkpoint (GO:0071174)2.54926870
147cell adhesion mediated by integrin (GO:0033627)2.54014562
148skin morphogenesis (GO:0043589)2.51484049
149UDP-N-acetylglucosamine metabolic process (GO:0006047)2.50724398

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.13619292
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.42431876
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.30485455
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.47744117
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.20787288
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.87279715
7* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.77164911
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.76580895
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.73484332
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.67748837
11* EST1_17652178_ChIP-ChIP_JURKAT_Human2.52819367
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.42383772
13XRN2_22483619_ChIP-Seq_HELA_Human2.35423793
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.33918792
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.33679141
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.27904344
17SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.25156395
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.23009118
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.21709263
20ZNF263_19887448_ChIP-Seq_K562_Human2.19463787
21AR_21909140_ChIP-Seq_LNCAP_Human2.17510623
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.16423744
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.06380783
24MYC_22102868_ChIP-Seq_BL_Human2.05130898
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.93569669
26PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.91641785
27E2F1_18555785_ChIP-Seq_MESCs_Mouse1.91046367
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.87221405
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.83525251
30E2F1_21310950_ChIP-Seq_MCF-7_Human1.81871572
31DCP1A_22483619_ChIP-Seq_HELA_Human1.73882368
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.73640945
33VDR_23849224_ChIP-Seq_CD4+_Human1.73322274
34TRIM28_21343339_ChIP-Seq_HEK293_Human1.69750367
35GABP_19822575_ChIP-Seq_HepG2_Human1.69164329
36* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.65443143
37* TTF2_22483619_ChIP-Seq_HELA_Human1.64258776
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.63358463
39POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.62394659
40FOXP3_21729870_ChIP-Seq_TREG_Human1.62123503
41ZFX_18555785_ChIP-Seq_MESCs_Mouse1.60964001
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.57048816
43* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.56749202
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53632551
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53369005
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.53092417
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51352238
48PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.48817681
49CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.48213070
50CIITA_25753668_ChIP-Seq_RAJI_Human1.48093815
51* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.44959828
52STAT3_1855785_ChIP-Seq_MESCs_Mouse1.43837854
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.40579077
54* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.39521506
55SOX17_20123909_ChIP-Seq_XEN_Mouse1.37867974
56SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.35799396
57VDR_21846776_ChIP-Seq_THP-1_Human1.35659363
58* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.33612752
59KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.33292195
60* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.33216532
61KDM5A_27292631_Chip-Seq_BREAST_Human1.30629024
62ELK1_19687146_ChIP-ChIP_HELA_Human1.30606253
63TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29876047
64ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28158780
65* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.28016208
66YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27419471
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.27407687
68PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21592772
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21425349
70HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20937289
71* SRF_21415370_ChIP-Seq_HL-1_Mouse1.18061923
72RARG_19884340_ChIP-ChIP_MEFs_Mouse1.16884423
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16307975
74EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.15757623
75KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15622459
76TP63_17297297_ChIP-ChIP_HaCaT_Human1.15614037
77ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.15278483
78RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15146100
79SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13259932
80YY1_21170310_ChIP-Seq_MESCs_Mouse1.12872518
81FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.12299727
82* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.12083387
83* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.12083387
84* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10364559
85ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10242257
86* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10125971
87TFEB_21752829_ChIP-Seq_HELA_Human1.09580696
88TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.09332106
89HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09253815
90TP63_19390658_ChIP-ChIP_HaCaT_Human1.08464915
91* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06270658
92ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04683347
93CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.04432224
94* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03991932
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02800867
96SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.02350300
97DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01219339
98ELK1_22589737_ChIP-Seq_MCF10A_Human1.01067817
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99794974
100* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99458234
101TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95493506
102POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94291265
103CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93687238
104OCT4_18692474_ChIP-Seq_MEFs_Mouse0.93338850
105TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93064516
106* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92868206
107ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92804260
108FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.92736060
109CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92531497
110* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.92289973
111STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.91363351
112PADI4_21655091_ChIP-ChIP_MCF-7_Human0.91047962
113BRD4_25478319_ChIP-Seq_HGPS_Human0.90953811
114* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.90214207
115ESR1_15608294_ChIP-ChIP_MCF-7_Human0.89878142
116* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.89681906
117SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.88758875
118CLOCK_20551151_ChIP-Seq_293T_Human0.87802141
119MYC_18940864_ChIP-ChIP_HL60_Human0.87751681
120GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87551840
121* ATF3_27146783_Chip-Seq_COLON_Human0.86997530
122SOX2_18555785_ChIP-Seq_MESCs_Mouse0.86204690
123PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.85855050
124NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.85757268
125TCF3_18692474_ChIP-Seq_MEFs_Mouse0.85607380
126SPI1_23547873_ChIP-Seq_NB4_Human0.84575986
127* ELK3_25401928_ChIP-Seq_HUVEC_Human0.82789889

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.81024952
2MP0002877_abnormal_melanocyte_morpholog3.65703372
3MP0004272_abnormal_basement_membrane3.60493369
4MP0004957_abnormal_blastocyst_morpholog3.48849788
5MP0010094_abnormal_chromosome_stability3.34284550
6MP0003111_abnormal_nucleus_morphology3.21955664
7MP0003077_abnormal_cell_cycle3.19910343
8MP0010352_gastrointestinal_tract_polyps2.93192251
9MP0003123_paternal_imprinting2.52817413
10MP0003705_abnormal_hypodermis_morpholog2.51394136
11MP0008007_abnormal_cellular_replicative2.51005253
12MP0010030_abnormal_orbit_morphology2.49276275
13MP0001730_embryonic_growth_arrest2.46911445
14MP0005257_abnormal_intraocular_pressure2.44879384
15MP0003806_abnormal_nucleotide_metabolis2.33968655
16MP0009697_abnormal_copulation2.19085010
17MP0008932_abnormal_embryonic_tissue2.10556491
18MP0008057_abnormal_DNA_replication1.97917291
19MP0000350_abnormal_cell_proliferation1.93370746
20MP0008058_abnormal_DNA_repair1.90363245
21MP0002396_abnormal_hematopoietic_system1.88492430
22MP0004084_abnormal_cardiac_muscle1.88444472
23MP0010307_abnormal_tumor_latency1.86637443
24MP0005408_hypopigmentation1.83131069
25MP0001697_abnormal_embryo_size1.74301907
26MP0003984_embryonic_growth_retardation1.74098865
27MP0005380_embryogenesis_phenotype1.73896837
28MP0001672_abnormal_embryogenesis/_devel1.73896837
29MP0002088_abnormal_embryonic_growth/wei1.71683368
30MP0005171_absent_coat_pigmentation1.63063346
31MP0000537_abnormal_urethra_morphology1.59530758
32MP0002060_abnormal_skin_morphology1.56505532
33MP0005623_abnormal_meninges_morphology1.55443484
34MP0003567_abnormal_fetal_cardiomyocyte1.53845206
35* MP0002080_prenatal_lethality1.53471722
36MP0005360_urolithiasis1.50639228
37MP0003566_abnormal_cell_adhesion1.49281573
38MP0003941_abnormal_skin_development1.48783633
39MP0005275_abnormal_skin_tensile1.47732350
40MP0003221_abnormal_cardiomyocyte_apopto1.47362461
41MP0000762_abnormal_tongue_morphology1.43363206
42MP0004197_abnormal_fetal_growth/weight/1.42833558
43MP0008877_abnormal_DNA_methylation1.42311296
44MP0003890_abnormal_embryonic-extraembry1.41808679
45MP0005023_abnormal_wound_healing1.41659695
46MP0005076_abnormal_cell_differentiation1.40990502
47MP0002086_abnormal_extraembryonic_tissu1.39930996
48MP0000490_abnormal_crypts_of1.39881301
49MP0004233_abnormal_muscle_weight1.38962615
50MP0009053_abnormal_anal_canal1.38748370
51MP0006054_spinal_hemorrhage1.38194651
52MP0004808_abnormal_hematopoietic_stem1.35126374
53MP0002085_abnormal_embryonic_tissue1.31814288
54MP0002084_abnormal_developmental_patter1.28519589
55MP0003718_maternal_effect1.27567191
56MP0000751_myopathy1.23632065
57MP0009333_abnormal_splenocyte_physiolog1.23187211
58MP0000313_abnormal_cell_death1.21741896
59MP0002019_abnormal_tumor_incidence1.19982202
60MP0001293_anophthalmia1.19615377
61MP0000858_altered_metastatic_potential1.13702061
62MP0000372_irregular_coat_pigmentation1.13372114
63MP0000749_muscle_degeneration1.12578058
64MP0005197_abnormal_uvea_morphology1.12390150
65MP0000750_abnormal_muscle_regeneration1.11878922
66MP0005501_abnormal_skin_physiology1.10043596
67MP0003121_genomic_imprinting1.09492579
68MP0010234_abnormal_vibrissa_follicle1.08348366
69MP0009672_abnormal_birth_weight1.06232563
70MP0001299_abnormal_eye_distance/1.05901502
71MP0003186_abnormal_redox_activity1.05528910
72MP0010630_abnormal_cardiac_muscle1.02543849
73MP0003385_abnormal_body_wall0.98915505
74MP0003763_abnormal_thymus_physiology0.97043906
75MP0001661_extended_life_span0.96646072
76MP0002938_white_spotting0.95712138
77MP0001853_heart_inflammation0.94901344
78MP0001881_abnormal_mammary_gland0.94484011
79MP0000358_abnormal_cell_content/0.94465185
80MP0002269_muscular_atrophy0.93625023
81MP0002796_impaired_skin_barrier0.93157237
82MP0010368_abnormal_lymphatic_system0.92890968
83MP0001915_intracranial_hemorrhage0.92594954
84* MP0002722_abnormal_immune_system0.91020399
85MP0000703_abnormal_thymus_morphology0.90973636
86MP0008438_abnormal_cutaneous_collagen0.90851472
87MP0001216_abnormal_epidermal_layer0.90822900
88MP0000747_muscle_weakness0.88624878
89MP0001849_ear_inflammation0.88111010
90MP0005165_increased_susceptibility_to0.88097121
91MP0001243_abnormal_dermal_layer0.87682872
92MP0005451_abnormal_body_composition0.87626874
93MP0003436_decreased_susceptibility_to0.87509478
94MP0005621_abnormal_cell_physiology0.87219629
95MP0008775_abnormal_heart_ventricle0.86587525
96MP0003091_abnormal_cell_migration0.86393901
97MP0003119_abnormal_digestive_system0.85755082
98MP0004782_abnormal_surfactant_physiolog0.85643256
99MP0003191_abnormal_cellular_cholesterol0.85430185
100MP0009780_abnormal_chondrocyte_physiolo0.85279540
101MP0001545_abnormal_hematopoietic_system0.84051690
102MP0005397_hematopoietic_system_phenotyp0.84051690
103MP0004087_abnormal_muscle_fiber0.83655890
104MP0008260_abnormal_autophagy0.82519377
105MP0005330_cardiomyopathy0.81168064
106* MP0000689_abnormal_spleen_morphology0.78893776
107MP0003937_abnormal_limbs/digits/tail_de0.78825966
108MP0005193_abnormal_anterior_eye0.78470893
109* MP0002398_abnormal_bone_marrow0.77907051
110MP0004133_heterotaxia0.77701130
111MP0000647_abnormal_sebaceous_gland0.77237329
112MP0000003_abnormal_adipose_tissue0.77200486
113MP0005266_abnormal_metabolism0.77161006
114MP0004036_abnormal_muscle_relaxation0.76872335
115MP0003315_abnormal_perineum_morphology0.76694418
116MP0002127_abnormal_cardiovascular_syste0.76693379
117MP0000477_abnormal_intestine_morphology0.76493684
118MP0000627_abnormal_mammary_gland0.75964113
119MP0004264_abnormal_extraembryonic_tissu0.75451315
120* MP0000266_abnormal_heart_morphology0.73970078
121MP0002111_abnormal_tail_morphology0.73362813
122MP0002234_abnormal_pharynx_morphology0.72336868
123MP0002177_abnormal_outer_ear0.70366858
124* MP0000598_abnormal_liver_morphology0.70323910
125MP0002089_abnormal_postnatal_growth/wei0.70252520
126MP0000579_abnormal_nail_morphology0.70170612
127MP0005385_cardiovascular_system_phenoty0.69991506
128MP0001544_abnormal_cardiovascular_syste0.69991506
129MP0003950_abnormal_plasma_membrane0.69492465
130MP0002006_tumorigenesis0.69169518
131MP0002896_abnormal_bone_mineralization0.69032410
132* MP0002429_abnormal_blood_cell0.68930072
133MP0003279_aneurysm0.68681500
134MP0002132_abnormal_respiratory_system0.67842633
135MP0003011_delayed_dark_adaptation0.67748744
136MP0002925_abnormal_cardiovascular_devel0.65912816
137MP0003942_abnormal_urinary_system0.65793861
138MP0002697_abnormal_eye_size0.65382572
139MP0006036_abnormal_mitochondrial_physio0.65283778
140MP0003786_premature_aging0.65271107
141MP0000759_abnormal_skeletal_muscle0.64384048
142MP0005384_cellular_phenotype0.64279401
143MP0001764_abnormal_homeostasis0.63270154
144MP0006035_abnormal_mitochondrial_morpho0.62908810
145MP0008770_decreased_survivor_rate0.62654667
146MP0003448_altered_tumor_morphology0.61678145
147MP0010155_abnormal_intestine_physiology0.58833592
148MP0000733_abnormal_muscle_development0.56282988

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.97652557
2Exercise-induced muscle cramps (HP:0003710)4.63513969
3Colon cancer (HP:0003003)3.81613179
4* Abnormality of glycolysis (HP:0004366)3.69017810
5Selective tooth agenesis (HP:0001592)3.59172249
6Oral leukoplakia (HP:0002745)3.36099754
7Cholecystitis (HP:0001082)3.32176288
8Abnormal gallbladder physiology (HP:0012438)3.32176288
9Reticulocytopenia (HP:0001896)3.31417478
10Ependymoma (HP:0002888)3.18402310
11Degeneration of anterior horn cells (HP:0002398)2.92057287
12Abnormality of the anterior horn cell (HP:0006802)2.92057287
13* Rhabdomyolysis (HP:0003201)2.91314880
14Multiple enchondromatosis (HP:0005701)2.88045931
15Entropion (HP:0000621)2.86899277
16Agnosia (HP:0010524)2.84149386
17Reduced subcutaneous adipose tissue (HP:0003758)2.83343474
18Abnormality of cells of the erythroid lineage (HP:0012130)2.82164560
19Birth length less than 3rd percentile (HP:0003561)2.81954351
20Trismus (HP:0000211)2.73303520
21Osteolytic defects of the phalanges of the hand (HP:0009771)2.66665981
22Osteolytic defects of the hand bones (HP:0009699)2.66665981
23Microglossia (HP:0000171)2.66563624
24Abnormal number of erythroid precursors (HP:0012131)2.66382373
25Reduced antithrombin III activity (HP:0001976)2.65953564
26Abnormality of abdominal situs (HP:0011620)2.58834273
27Abdominal situs inversus (HP:0003363)2.58834273
28Abnormality of reticulocytes (HP:0004312)2.54366868
29Medulloblastoma (HP:0002885)2.53675765
30Ankyloglossia (HP:0010296)2.52806812
31Upper limb muscle weakness (HP:0003484)2.52665482
32Abnormality of the umbilical cord (HP:0010881)2.47594177
33Chromsome breakage (HP:0040012)2.47254507
34Adenoma sebaceum (HP:0009720)2.45132422
35Angiofibromas (HP:0010615)2.45132422
36* Increased serum pyruvate (HP:0003542)2.43923173
37Increased density of long bones (HP:0006392)2.42158450
38Chromosomal breakage induced by crosslinking agents (HP:0003221)2.41299272
39Deviation of the thumb (HP:0009603)2.39634824
40Abnormality of pyrimidine metabolism (HP:0004353)2.36314529
41Abnormality of the intrinsic pathway (HP:0010989)2.35373783
42Cholelithiasis (HP:0001081)2.33396291
43Abnormal number of incisors (HP:0011064)2.32752511
44Aplastic anemia (HP:0001915)2.32521639
45Abnormalities of placenta or umbilical cord (HP:0001194)2.31271023
46Type I transferrin isoform profile (HP:0003642)2.30926255
47Posterior subcapsular cataract (HP:0007787)2.29448984
48Short nail (HP:0001799)2.29385527
49Proximal placement of thumb (HP:0009623)2.26665198
50Cellular immunodeficiency (HP:0005374)2.26352628
51Protrusio acetabuli (HP:0003179)2.25973811
52Follicular hyperkeratosis (HP:0007502)2.25709772
53Cutaneous melanoma (HP:0012056)2.24675565
54Sparse eyelashes (HP:0000653)2.24067158
55Microvesicular hepatic steatosis (HP:0001414)2.23991640
56Thrombocytosis (HP:0001894)2.21574694
57Vertebral compression fractures (HP:0002953)2.21352497
58Neoplasm of the pancreas (HP:0002894)2.19387360
59Microretrognathia (HP:0000308)2.18942911
60Onycholysis (HP:0001806)2.17900024
61Abnormality of oral frenula (HP:0000190)2.17297871
62Abnormality of the calcaneus (HP:0008364)2.17297591
63Arterial tortuosity (HP:0005116)2.17098378
64Elbow flexion contracture (HP:0002987)2.14927051
65Pendular nystagmus (HP:0012043)2.14355803
66Glucose intolerance (HP:0000833)2.12789581
67Atrophic scars (HP:0001075)2.11381480
68Reticulocytosis (HP:0001923)2.11025900
69Vascular tortuosity (HP:0004948)2.07975099
70Abnormal gallbladder morphology (HP:0012437)2.07708628
71Amniotic constriction ring (HP:0009775)2.05413433
72Abnormality of placental membranes (HP:0011409)2.05413433
73* Myoglobinuria (HP:0002913)2.05307007
74Basal cell carcinoma (HP:0002671)2.05041016
75Hypoplasia of the capital femoral epiphysis (HP:0003090)2.03610347
76Carpal bone hypoplasia (HP:0001498)2.01693167
77Ankle contracture (HP:0006466)2.01616929
78Breast hypoplasia (HP:0003187)2.00961482
79Orthostatic hypotension (HP:0001278)2.00521124
80Pterygium (HP:0001059)1.98660369
81Ragged-red muscle fibers (HP:0003200)1.97832939
82Secondary amenorrhea (HP:0000869)1.96852718
83High pitched voice (HP:0001620)1.95926886
84Increased nuchal translucency (HP:0010880)1.95807701
85Rough bone trabeculation (HP:0100670)1.95591135
86Wormian bones (HP:0002645)1.94287919
87Macrocytic anemia (HP:0001972)1.93959958
88Abnormal lung lobation (HP:0002101)1.93057104
89Centrally nucleated skeletal muscle fibers (HP:0003687)1.92733699
90Breech presentation (HP:0001623)1.92502761
91Absent thumb (HP:0009777)1.92170167
92Pallor (HP:0000980)1.91237519
93Aortic dissection (HP:0002647)1.91097381
94Neoplasm of the colon (HP:0100273)1.91027189
95Renal duplication (HP:0000075)1.90217223
96Abnormality of the astrocytes (HP:0100707)1.90043735
97Astrocytoma (HP:0009592)1.90043735
98Rhabdomyosarcoma (HP:0002859)1.89162292
99Abnormal umbilical cord blood vessels (HP:0011403)1.88851422
100Single umbilical artery (HP:0001195)1.88851422
101Abnormality of the fetal cardiovascular system (HP:0010948)1.88851422
102Abnormality of carpal bone ossification (HP:0006257)1.88510209
103Congenital stationary night blindness (HP:0007642)1.88145210
104Bifid uvula (HP:0000193)1.87372354
105Premature graying of hair (HP:0002216)1.86787497
10611 pairs of ribs (HP:0000878)1.86261216
107Spastic diplegia (HP:0001264)1.85256769
108Intestinal polyp (HP:0005266)1.84337582
109Short 4th metacarpal (HP:0010044)1.84054557
110Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.84054557
111Abnormal delivery (HP:0001787)1.83839239
112Ovarian neoplasm (HP:0100615)1.82549354
113Abnormal auditory evoked potentials (HP:0006958)1.82401744
114Abnormality of the distal phalanges of the toes (HP:0010182)1.81417867
115Preauricular skin tag (HP:0000384)1.81213229
116Right ventricular cardiomyopathy (HP:0011663)1.80419600
117Abnormality of dentin (HP:0010299)1.80359675
118Spinal rigidity (HP:0003306)1.80249958
119Missing ribs (HP:0000921)1.80235326
120Severe visual impairment (HP:0001141)1.80186132
121Abnormality of methionine metabolism (HP:0010901)1.80050885
122Patellar aplasia (HP:0006443)1.78860144
123Ulnar deviation of the wrist (HP:0003049)1.78178878
124Calcaneovalgus deformity (HP:0001848)1.77516986
125Intestinal polyposis (HP:0200008)1.77070523
126T lymphocytopenia (HP:0005403)1.76993923
127Small epiphyses (HP:0010585)1.76714832
128Neoplasm of the rectum (HP:0100743)1.76694365
129Progressive muscle weakness (HP:0003323)1.75668918
130Insomnia (HP:0100785)1.75130795
131Gout (HP:0001997)1.75085138
132Poikiloderma (HP:0001029)1.74554216
133Biliary tract neoplasm (HP:0100574)1.74447111
134Skin tags (HP:0010609)1.73276134
135Ureteral duplication (HP:0000073)1.72578688
136Natal tooth (HP:0000695)1.71308953
137Atrophy/Degeneration involving motor neurons (HP:0007373)1.71207312
138Abnormality of the acetabulum (HP:0003170)1.70813682
139Aplasia/Hypoplasia of the patella (HP:0006498)1.67150745
140Soft skin (HP:0000977)1.66975284
141Hypoplastic pelvis (HP:0008839)1.66549999
142Nausea (HP:0002018)1.66464769
143Atresia of the external auditory canal (HP:0000413)1.66100119
144Abnormality of the preputium (HP:0100587)1.65169785
145Bicuspid aortic valve (HP:0001647)1.64026399
146Limb-girdle muscle atrophy (HP:0003797)1.63924348
147Deformed tarsal bones (HP:0008119)1.63883187
148Tracheoesophageal fistula (HP:0002575)1.63207599
149Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.62049843
150Abnormal protein N-linked glycosylation (HP:0012347)1.62049843
151Abnormal protein glycosylation (HP:0012346)1.62049843
152Abnormal glycosylation (HP:0012345)1.62049843
153Hypobetalipoproteinemia (HP:0003563)1.61987353
154Aortic aneurysm (HP:0004942)1.61535861
155Abnormal trabecular bone morphology (HP:0100671)1.61261422
156Myelodysplasia (HP:0002863)1.60782041
157Bladder diverticulum (HP:0000015)1.60725733
158Abnormality of chromosome stability (HP:0003220)1.60596113
159Achilles tendon contracture (HP:0001771)1.60336458
160Aplasia/hypoplasia of the humerus (HP:0006507)1.59458656
161Delayed cranial suture closure (HP:0000270)1.59340115
162Neck muscle weakness (HP:0000467)1.59236770
163Squamous cell carcinoma (HP:0002860)1.58863094
164Amaurosis fugax (HP:0100576)1.58516353
165Increased connective tissue (HP:0009025)1.58158132
166Chorioretinal atrophy (HP:0000533)1.57704946
167Abnormality of T cell number (HP:0011839)1.57249707
168Small intestinal stenosis (HP:0012848)1.57129369
169Duodenal stenosis (HP:0100867)1.57129369
170Rectal prolapse (HP:0002035)1.57126322
171Hyperacusis (HP:0010780)1.57120055
172Ridged nail (HP:0001807)1.57077999
173Glossoptosis (HP:0000162)1.56918980
174Mesangial abnormality (HP:0001966)1.56620103
175Alopecia of scalp (HP:0002293)1.56542770
176Termporal pattern (HP:0011008)1.53404307
177Insidious onset (HP:0003587)1.53404307
178Ileus (HP:0002595)1.52437577
179Cardiovascular calcification (HP:0011915)1.52146296
180Postnatal microcephaly (HP:0005484)1.52131905
181Abnormality of the gallbladder (HP:0005264)1.50097237
182Fragile skin (HP:0001030)1.49672282
183Blepharitis (HP:0000498)1.49187000

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.70361442
2PKN23.60693591
3CDC73.43426378
4NEK12.99729090
5MST1R2.96774321
6WEE12.85717986
7EIF2AK12.75238264
8VRK22.63249710
9TESK22.48365919
10TESK12.45962701
11TSSK62.38627771
12EEF2K2.23103774
13NEK22.07199193
14TRIB32.03168430
15RPS6KA41.88644551
16KDR1.78467716
17FLT31.77466418
18NME21.76459821
19MAP3K101.75479054
20MST41.72324371
21PASK1.71654700
22SCYL21.68740381
23STK101.68239278
24MAP3K81.62950539
25MET1.62942737
26TGFBR11.62017842
27PAK41.61233956
28OBSCN1.60939851
29TTK1.59263784
30RPS6KB21.57839450
31ARAF1.53604498
32PLK41.50823380
33MAP2K31.43907269
34TTN1.43683291
35LRRK21.37883996
36ERBB41.37746337
37AURKB1.33523409
38ATR1.32822155
39TRIM281.31584441
40PLK11.29011465
41CDK71.28064541
42CDK41.27467268
43EIF2AK31.26936537
44PTK21.26845402
45MAP3K121.25553074
46SRPK11.24415314
47MAP3K111.18290804
48IRAK31.15501487
49PLK31.14646183
50PBK1.14065478
51BCKDK1.12430822
52MAP4K11.11537853
53BRSK21.11450561
54MOS1.11031483
55SMG11.09160802
56PDK31.08420851
57PDK41.08420851
58LATS11.08399073
59BCR1.05538679
60MAPKAPK51.03070617
61LATS21.00720293
62LIMK10.99744167
63MKNK10.93565667
64STK40.93139806
65CHEK10.92059131
66EIF2AK20.91770307
67PDGFRA0.87506338
68SIK30.85974867
69AURKA0.85395824
70ILK0.85322429
71BRSK10.80565556
72PAK10.80383243
73LMTK20.79883193
74CLK10.79215700
75CDK120.78717193
76CDK60.77628258
77ACVR1B0.77420896
78PIM20.77400733
79BRAF0.76665809
80ICK0.76462148
81MAP3K30.76327677
82ERBB30.74360880
83TAOK20.73681616
84VRK10.71595831
85JAK30.71533116
86GRK60.69806147
87PAK20.69598364
88MYLK0.68162720
89ALK0.67387017
90CHEK20.66959654
91ZAP700.64481642
92TAF10.62887249
93AKT20.60355043
94PTK60.59660767
95NME10.59583321
96ATM0.57732667
97NEK90.57334576
98CCNB10.57222864
99DAPK10.57002158
100RAF10.55216714
101EPHA20.54807893
102PIM10.54488452
103ERN10.53992021
104CDK20.53914544
105PLK20.53909162
106MAP3K90.53596294
107STK38L0.51893863
108CSNK2A20.51629352
109CSNK2A10.51394659
110STK240.50667938
111TYK20.48638032
112CDK180.48573014
113BLK0.48083793
114BTK0.47670653
115TLK10.45035699
116CDK80.43778657
117MTOR0.43731575
118ZAK0.43417525
119CDK140.43046415
120CDK150.41558564
121CDK90.40531135
122FER0.39724138
123CDK11A0.38826039
124PRKCI0.37072540
125MAP3K50.36997840
126STK30.36979568
127FGFR40.35284661
128* FGFR10.33603040
129PDK20.33528841
130NTRK10.33129753
131RIPK10.32560634
132* CDK10.32105419
133TRPM70.32020135
134STK160.31630724
135DAPK30.30699210
136MELK0.29696261
137MAPKAPK30.28913559
138SIK10.24831651

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.62230693
2Mismatch repair_Homo sapiens_hsa034303.71840955
3One carbon pool by folate_Homo sapiens_hsa006703.18464359
4Proteasome_Homo sapiens_hsa030503.08474186
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.74883644
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.74738703
7Spliceosome_Homo sapiens_hsa030402.72687089
8Ribosome_Homo sapiens_hsa030102.71336039
9RNA transport_Homo sapiens_hsa030132.64535927
10Biosynthesis of amino acids_Homo sapiens_hsa012302.63137271
11Base excision repair_Homo sapiens_hsa034102.60884467
12* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.33628610
13Nucleotide excision repair_Homo sapiens_hsa034202.20340883
14Cell cycle_Homo sapiens_hsa041102.16830782
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.13477712
16Carbon metabolism_Homo sapiens_hsa012002.12683594
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.06905139
18Protein export_Homo sapiens_hsa030602.06889093
19RNA polymerase_Homo sapiens_hsa030202.05110821
20Pyrimidine metabolism_Homo sapiens_hsa002402.03255323
21Homologous recombination_Homo sapiens_hsa034401.98345687
22Pentose phosphate pathway_Homo sapiens_hsa000301.79150464
23RNA degradation_Homo sapiens_hsa030181.68294252
24Fructose and mannose metabolism_Homo sapiens_hsa000511.46610355
25Galactose metabolism_Homo sapiens_hsa000521.37227244
26Fatty acid elongation_Homo sapiens_hsa000621.31339282
27* Cysteine and methionine metabolism_Homo sapiens_hsa002701.31192713
28* Central carbon metabolism in cancer_Homo sapiens_hsa052301.25590917
29Non-homologous end-joining_Homo sapiens_hsa034501.24923308
30Steroid biosynthesis_Homo sapiens_hsa001001.24051299
31Cyanoamino acid metabolism_Homo sapiens_hsa004601.21241080
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.17885229
33p53 signaling pathway_Homo sapiens_hsa041151.14828360
34Vitamin B6 metabolism_Homo sapiens_hsa007501.14748492
35mRNA surveillance pathway_Homo sapiens_hsa030151.13640887
36Fanconi anemia pathway_Homo sapiens_hsa034601.13000284
37* HIF-1 signaling pathway_Homo sapiens_hsa040661.06830992
38Purine metabolism_Homo sapiens_hsa002301.06590257
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.04253369
40Legionellosis_Homo sapiens_hsa051341.00571128
41Selenocompound metabolism_Homo sapiens_hsa004501.00186797
42Epstein-Barr virus infection_Homo sapiens_hsa051690.98364445
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.97339016
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.95859663
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92688973
46Drug metabolism - other enzymes_Homo sapiens_hsa009830.92593929
47Viral carcinogenesis_Homo sapiens_hsa052030.92119624
48* Pyruvate metabolism_Homo sapiens_hsa006200.87551276
49Thyroid cancer_Homo sapiens_hsa052160.84394846
50Antigen processing and presentation_Homo sapiens_hsa046120.83139855
51Systemic lupus erythematosus_Homo sapiens_hsa053220.81093565
52HTLV-I infection_Homo sapiens_hsa051660.77582789
53Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.77362964
54ECM-receptor interaction_Homo sapiens_hsa045120.76401671
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73814769
56Sulfur relay system_Homo sapiens_hsa041220.73152415
57Sulfur metabolism_Homo sapiens_hsa009200.71545280
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69808324
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68242656
60Glutathione metabolism_Homo sapiens_hsa004800.67859597
61Viral myocarditis_Homo sapiens_hsa054160.66432699
62Phenylalanine metabolism_Homo sapiens_hsa003600.65415188
63Arginine biosynthesis_Homo sapiens_hsa002200.64413333
64Herpes simplex infection_Homo sapiens_hsa051680.62819748
65Small cell lung cancer_Homo sapiens_hsa052220.60073241
66Basal transcription factors_Homo sapiens_hsa030220.57850237
67Bladder cancer_Homo sapiens_hsa052190.57370491
68* Propanoate metabolism_Homo sapiens_hsa006400.56329290
69Oxidative phosphorylation_Homo sapiens_hsa001900.56012604
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55688713
71Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54334528
72Focal adhesion_Homo sapiens_hsa045100.52545389
73Vibrio cholerae infection_Homo sapiens_hsa051100.52100474
74Parkinsons disease_Homo sapiens_hsa050120.50460186
75Fatty acid metabolism_Homo sapiens_hsa012120.49626647
76Oocyte meiosis_Homo sapiens_hsa041140.48762022
77Lysine degradation_Homo sapiens_hsa003100.48055072
78MicroRNAs in cancer_Homo sapiens_hsa052060.48014933
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47922039
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46223478
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45919095
82Huntingtons disease_Homo sapiens_hsa050160.45212892
83Shigellosis_Homo sapiens_hsa051310.44004979
84Apoptosis_Homo sapiens_hsa042100.43884713
85Alzheimers disease_Homo sapiens_hsa050100.43805264
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41457415
87Adherens junction_Homo sapiens_hsa045200.41303223
88Folate biosynthesis_Homo sapiens_hsa007900.40813785
89Pancreatic cancer_Homo sapiens_hsa052120.39820368
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38502584
91Chronic myeloid leukemia_Homo sapiens_hsa052200.37923682
92Measles_Homo sapiens_hsa051620.37823523
93Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.35386338
94Hippo signaling pathway_Homo sapiens_hsa043900.35181401
95Tyrosine metabolism_Homo sapiens_hsa003500.34468805
96TGF-beta signaling pathway_Homo sapiens_hsa043500.34138711
97Cardiac muscle contraction_Homo sapiens_hsa042600.33023895
98Basal cell carcinoma_Homo sapiens_hsa052170.32832844
99Fat digestion and absorption_Homo sapiens_hsa049750.31390390
100Acute myeloid leukemia_Homo sapiens_hsa052210.30633614
101Colorectal cancer_Homo sapiens_hsa052100.30411798
102Hepatitis B_Homo sapiens_hsa051610.30277049
103Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30069629
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29550984
105N-Glycan biosynthesis_Homo sapiens_hsa005100.29168861
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29150040
107Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28357293
108Fatty acid degradation_Homo sapiens_hsa000710.27846008
109Starch and sucrose metabolism_Homo sapiens_hsa005000.27441528
110Mineral absorption_Homo sapiens_hsa049780.25212762
111Arginine and proline metabolism_Homo sapiens_hsa003300.24975339
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.22550604
113Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.21294212
114* Metabolic pathways_Homo sapiens_hsa011000.20869001
115Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.20703034
116Leishmaniasis_Homo sapiens_hsa051400.20361075
117Proteoglycans in cancer_Homo sapiens_hsa052050.20085645
118Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.19504902
119Primary immunodeficiency_Homo sapiens_hsa053400.18784467
120Renin-angiotensin system_Homo sapiens_hsa046140.18723610
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.17354622
122Pathways in cancer_Homo sapiens_hsa052000.16577006
123Influenza A_Homo sapiens_hsa051640.16544828
124Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.15752188
125* Glucagon signaling pathway_Homo sapiens_hsa049220.13516912

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