LCP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.66260781
2antigen processing and presentation of endogenous antigen (GO:0019883)5.51672490
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.42824875
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.42824875
5regulation of B cell receptor signaling pathway (GO:0050855)5.12007478
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.86194474
7leukocyte aggregation (GO:0070486)4.76910444
8positive regulation by symbiont of host defense response (GO:0052509)4.58821599
9modulation by symbiont of host defense response (GO:0052031)4.58821599
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.58821599
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.58821599
12positive regulation by organism of defense response of other organism involved in symbiotic interact4.58821599
13modulation by symbiont of host immune response (GO:0052553)4.58821599
14detection of other organism (GO:0098543)4.48034398
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.25486442
16detection of bacterium (GO:0016045)4.23631150
17negative thymic T cell selection (GO:0045060)4.15572500
18immunoglobulin mediated immune response (GO:0016064)4.13035836
19neutrophil activation involved in immune response (GO:0002283)4.11856138
20negative T cell selection (GO:0043383)4.06112395
21regulation of gamma-delta T cell differentiation (GO:0045586)4.04579492
22negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.03654281
23negative regulation of cell killing (GO:0031342)4.03654281
24regulation of gamma-delta T cell activation (GO:0046643)3.95422817
25regulation of interferon-beta biosynthetic process (GO:0045357)3.94354660
26negative regulation of T cell mediated immunity (GO:0002710)3.91727599
27negative regulation of lymphocyte mediated immunity (GO:0002707)3.91238294
28response to peptidoglycan (GO:0032494)3.90003638
29Arp2/3 complex-mediated actin nucleation (GO:0034314)3.89689468
30detection of external biotic stimulus (GO:0098581)3.88611084
31positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.86334874
32detection of molecule of bacterial origin (GO:0032490)3.86181186
33positive regulation of B cell differentiation (GO:0045579)3.84047786
34regulation of B cell differentiation (GO:0045577)3.82916312
35regulation of interleukin-12 biosynthetic process (GO:0045075)3.80429049
36positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.76481919
37positive thymic T cell selection (GO:0045059)3.76132069
38respiratory burst (GO:0045730)3.72290696
39T cell migration (GO:0072678)3.71202990
40positive regulation of interferon-alpha production (GO:0032727)3.64998150
41regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.63902818
42B cell receptor signaling pathway (GO:0050853)3.62428826
43microglial cell activation (GO:0001774)3.53012921
44regulation of interferon-alpha production (GO:0032647)3.52701200
45negative regulation of leukocyte mediated immunity (GO:0002704)3.50896368
46response to interleukin-15 (GO:0070672)3.49106073
47cellular extravasation (GO:0045123)3.48502959
48tolerance induction (GO:0002507)3.47934629
49detection of biotic stimulus (GO:0009595)3.43530965
50interferon-gamma production (GO:0032609)3.43124119
51positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.42866413
52positive regulation of antigen processing and presentation (GO:0002579)3.39575160
53neutrophil activation (GO:0042119)3.39197692
54regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.37962042
55B cell mediated immunity (GO:0019724)3.34076604
56regulation of alpha-beta T cell proliferation (GO:0046640)3.33532268
57myeloid dendritic cell activation (GO:0001773)3.32080938
58regulation of mast cell degranulation (GO:0043304)3.26582500
59response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.25596186
60response to host immune response (GO:0052572)3.25596186
61positive regulation of mast cell activation (GO:0033005)3.25592280
62granulocyte activation (GO:0036230)3.25581539
63cellular response to interleukin-15 (GO:0071350)3.25133188
64thymic T cell selection (GO:0045061)3.23856813
65interferon-gamma-mediated signaling pathway (GO:0060333)3.23097605
66macrophage activation (GO:0042116)3.22732537
67defense response to protozoan (GO:0042832)3.22215743
68macrophage activation involved in immune response (GO:0002281)3.21852259
69mast cell activation (GO:0045576)3.19806845
70response to type I interferon (GO:0034340)3.17298359
71NIK/NF-kappaB signaling (GO:0038061)3.17043726
72myeloid dendritic cell differentiation (GO:0043011)3.16695026
73type I interferon signaling pathway (GO:0060337)3.15905658
74cellular response to type I interferon (GO:0071357)3.15905658
75leukocyte cell-cell adhesion (GO:0007159)3.14494274
76regulation of tolerance induction (GO:0002643)3.14257298
77myeloid cell activation involved in immune response (GO:0002275)3.13392246
78response to muramyl dipeptide (GO:0032495)3.13257738
79response to protozoan (GO:0001562)3.12117892
80negative regulation of interleukin-12 production (GO:0032695)3.11137547
81regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.09485676
82negative regulation of phagocytosis (GO:0050765)3.08880085
83positive regulation of alpha-beta T cell proliferation (GO:0046641)3.06356110
84negative regulation of erythrocyte differentiation (GO:0045647)3.05496989
85negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.03376314
86T cell selection (GO:0045058)3.02443777
87positive regulation of isotype switching (GO:0045830)3.02197976
88regulation of mast cell activation (GO:0033003)3.01397008
89response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.00827146
90response to host (GO:0075136)3.00827146
91response to host defenses (GO:0052200)3.00827146
92cellular response to zinc ion (GO:0071294)3.00527409
93leukocyte degranulation (GO:0043299)2.99992612
94production of molecular mediator involved in inflammatory response (GO:0002532)2.99697031
95regulation of mast cell activation involved in immune response (GO:0033006)2.99054553
96JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.98723488
97actin nucleation (GO:0045010)2.98636126
98positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.98541748
99regulation of T cell mediated cytotoxicity (GO:0001914)2.98448671
100lipopolysaccharide-mediated signaling pathway (GO:0031663)2.96965727
101positive T cell selection (GO:0043368)2.96320825
102positive regulation of interleukin-2 production (GO:0032743)2.95029140
103regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.93098787
104regulation of natural killer cell mediated immunity (GO:0002715)2.93098787
105neutrophil mediated immunity (GO:0002446)2.91955831
106regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.91512698
107pinocytosis (GO:0006907)2.90823356
108regulation of antigen processing and presentation (GO:0002577)2.90322848
109activated T cell proliferation (GO:0050798)2.89815503
110regulation of myeloid leukocyte mediated immunity (GO:0002886)2.89804812
111regulation of interleukin-2 biosynthetic process (GO:0045076)2.88724774
112regulation of T cell tolerance induction (GO:0002664)2.87718813
113T cell costimulation (GO:0031295)2.87327868
114positive regulation of granulocyte differentiation (GO:0030854)2.86392785
115positive regulation of T cell mediated cytotoxicity (GO:0001916)2.84975954
116negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.84412891
117antigen processing and presentation via MHC class Ib (GO:0002475)2.84303902
118positive regulation of immunoglobulin mediated immune response (GO:0002891)2.83496237
119positive regulation of B cell mediated immunity (GO:0002714)2.83496237
120regulation of T cell receptor signaling pathway (GO:0050856)2.83218259
121lymphocyte costimulation (GO:0031294)2.82995089
122germinal center formation (GO:0002467)2.81649466
123positive regulation of humoral immune response (GO:0002922)2.79087766
124positive regulation of cytokine biosynthetic process (GO:0042108)2.78930119
125regulation of dendritic cell antigen processing and presentation (GO:0002604)2.76635113
126positive regulation of interferon-beta production (GO:0032728)2.73912427
127antigen receptor-mediated signaling pathway (GO:0050851)2.72986444
128T cell proliferation (GO:0042098)2.72075702
129regulation of response to interferon-gamma (GO:0060330)2.71831483
130natural killer cell mediated cytotoxicity (GO:0042267)2.71288428

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.37019374
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.01346792
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.97829407
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.33397970
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.29953574
6E2F7_22180533_ChIP-Seq_HELA_Human4.26895866
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.93365839
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.63473515
9IRF8_27001747_Chip-Seq_BMDM_Mouse3.41054943
10EGR1_19374776_ChIP-ChIP_THP-1_Human3.24960029
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.22585221
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.18349061
13* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.12068704
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.06500247
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.04375593
16* MYB_21317192_ChIP-Seq_ERMYB_Mouse3.00692211
17* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.85226575
18* MYB_26560356_Chip-Seq_TH2_Human2.54423691
19MYC_22102868_ChIP-Seq_BL_Human2.49293941
20* SPI1_23547873_ChIP-Seq_NB4_Human2.44717528
21RUNX_20019798_ChIP-Seq_JUKART_Human2.42928572
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.36443030
23VDR_21846776_ChIP-Seq_THP-1_Human2.34103406
24MAF_26560356_Chip-Seq_TH1_Human2.33462177
25SCL_19346495_ChIP-Seq_HPC-7_Human2.32577324
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.30551008
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.26390913
28* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.22261071
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.20616927
30* MYB_26560356_Chip-Seq_TH1_Human2.16721832
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.13726535
32ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.07523987
33* RUNX1_22412390_ChIP-Seq_EML_Mouse2.03197350
34VDR_24763502_ChIP-Seq_THP-1_Human2.02415372
35RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.98224641
36* UTX_26944678_Chip-Seq_JUKART_Human1.90030748
37* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.89794848
38FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.82007990
39* SPI1_23127762_ChIP-Seq_K562_Human1.73859124
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.69598511
41MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.66100972
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.64363025
43PU_27001747_Chip-Seq_BMDM_Mouse1.63005393
44TCF7_22412390_ChIP-Seq_EML_Mouse1.58084567
45FOXM1_23109430_ChIP-Seq_U2OS_Human1.57926888
46* GATA3_27048872_Chip-Seq_THYMUS_Human1.55638480
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.49051915
48* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.47933486
49* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.44956116
50CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.43322216
51GATA2_22383799_ChIP-Seq_G1ME_Mouse1.41941188
52* MAF_26560356_Chip-Seq_TH2_Human1.41897850
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.41308133
54STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.41129052
55LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.39601921
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37007052
57CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34724430
58GATA3_26560356_Chip-Seq_TH2_Human1.25124885
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.23694786
60KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.23240553
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18801858
62CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17748851
63GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.15109604
64* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.14390553
65* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14387753
66KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.13875271
67GATA1_22025678_ChIP-Seq_K562_Human1.13305304
68CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11850767
69NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.10965048
70E2F4_17652178_ChIP-ChIP_JURKAT_Human1.09088889
71LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.08958334
72ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08313065
73VDR_24787735_ChIP-Seq_THP-1_Human1.07918969
74GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07507256
75SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07378525
76* SMAD_19615063_ChIP-ChIP_OVARY_Human1.06713907
77TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05002831
78KDM2B_26808549_Chip-Seq_DND41_Human1.03818023
79* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.03673488
80PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03651412
81GATA1_19941826_ChIP-Seq_K562_Human1.02445743
82GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01873252
83GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99588380
84PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98399794
85ELK3_25401928_ChIP-Seq_HUVEC_Human0.96676226
86PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95244226
87KDM2B_26808549_Chip-Seq_JURKAT_Human0.92301273
88* GATA1_19941827_ChIP-Seq_MEL_Mouse0.92059797
89VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.91967067
90KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91095610
91TFEB_21752829_ChIP-Seq_HELA_Human0.90763639
92TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90276943
93SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90252659
94* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89350897
95PU.1_20513432_ChIP-Seq_Bcells_Mouse0.88760882
96* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.86806942
97BCL6_27268052_Chip-Seq_Bcells_Human0.85223318
98CIITA_25753668_ChIP-Seq_RAJI_Human0.85148349
99VDR_23849224_ChIP-Seq_CD4+_Human0.77643268
100LXR_22292898_ChIP-Seq_THP-1_Human0.77353534
101BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.76299581
102BCOR_27268052_Chip-Seq_Bcells_Human0.76029736
103GATA2_21666600_ChIP-Seq_HMVEC_Human0.72488133
104NCOR1_26117541_ChIP-Seq_K562_Human0.71648667
105SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.69643249
106E2F1_21310950_ChIP-Seq_MCF-7_Human0.69640890
107THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.69430868
108FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.69211420
109ELK1_19687146_ChIP-ChIP_HELA_Human0.68135665
110FOXP3_21729870_ChIP-Seq_TREG_Human0.67170426
111ETS1_22383799_ChIP-Seq_G1ME_Mouse0.66880078
112* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66023287
113SPI1_20517297_ChIP-Seq_HL60_Human0.65920067
114GATA2_19941826_ChIP-Seq_K562_Human0.65382691

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.57609440
2MP0003436_decreased_susceptibility_to3.52625255
3MP0005671_abnormal_response_to3.41131453
4MP0009785_altered_susceptibility_to3.28753032
5MP0000685_abnormal_immune_system3.25363822
6MP0003303_peritoneal_inflammation3.17282883
7MP0001800_abnormal_humoral_immune3.13429979
8MP0005000_abnormal_immune_tolerance3.11738604
9MP0005387_immune_system_phenotype3.11336166
10MP0001790_abnormal_immune_system3.11336166
11* MP0002452_abnormal_antigen_presenting2.84926499
12* MP0002419_abnormal_innate_immunity2.81401132
13MP0002148_abnormal_hypersensitivity_rea2.80067481
14* MP0005025_abnormal_response_to2.79179014
15* MP0002723_abnormal_immune_serum2.71744858
16* MP0002420_abnormal_adaptive_immunity2.64625948
17* MP0001819_abnormal_immune_cell2.63517579
18MP0006082_CNS_inflammation2.56180641
19MP0003763_abnormal_thymus_physiology2.55946560
20MP0002405_respiratory_system_inflammati2.30019303
21MP0003724_increased_susceptibility_to2.29840903
22MP0002398_abnormal_bone_marrow2.29284772
23MP0005464_abnormal_platelet_physiology2.18112730
24MP0003300_gastrointestinal_ulcer2.16381233
25MP0000716_abnormal_immune_system2.14966903
26MP0002166_altered_tumor_susceptibility2.12805409
27MP0002396_abnormal_hematopoietic_system2.08642360
28MP0001853_heart_inflammation2.05264481
29MP0009333_abnormal_splenocyte_physiolog1.95046027
30MP0000689_abnormal_spleen_morphology1.94712397
31MP0010155_abnormal_intestine_physiology1.91975880
32MP0004510_myositis1.89024703
33MP0001845_abnormal_inflammatory_respons1.88844441
34MP0002006_tumorigenesis1.86577488
35MP0005058_abnormal_lysosome_morphology1.86309539
36MP0002722_abnormal_immune_system1.83431654
37MP0002429_abnormal_blood_cell1.78949177
38MP0004947_skin_inflammation1.78340889
39MP0001873_stomach_inflammation1.74082335
40MP0001533_abnormal_skeleton_physiology1.70591728
41MP0005451_abnormal_body_composition1.69997467
42MP0009278_abnormal_bone_marrow1.69895982
43MP0003172_abnormal_lysosome_physiology1.60523258
44MP0001545_abnormal_hematopoietic_system1.59107366
45MP0005397_hematopoietic_system_phenotyp1.59107366
46MP0008260_abnormal_autophagy1.58933691
47MP0004808_abnormal_hematopoietic_stem1.58528251
48MP0005310_abnormal_salivary_gland1.53699202
49MP0008469_abnormal_protein_level1.48270540
50MP0000703_abnormal_thymus_morphology1.47730672
51MP0003448_altered_tumor_morphology1.47127411
52MP0000465_gastrointestinal_hemorrhage1.46153341
53MP0000858_altered_metastatic_potential1.43197654
54MP0002933_joint_inflammation1.42990362
55MP0003183_abnormal_peptide_metabolism1.41301136
56MP0003866_abnormal_defecation1.36155672
57MP0009764_decreased_sensitivity_to1.28698456
58MP0004381_abnormal_hair_follicle1.28416420
59MP0005174_abnormal_tail_pigmentation1.25301369
60MP0000343_altered_response_to1.23977017
61MP0000569_abnormal_digit_pigmentation1.21061574
62MP0000490_abnormal_crypts_of1.19452017
63MP0003191_abnormal_cellular_cholesterol1.14183618
64MP0010307_abnormal_tumor_latency1.13998163
65MP0004883_abnormal_blood_vessel1.09197632
66MP0002009_preneoplasia1.06623404
67MP0001851_eye_inflammation1.01419009
68MP0000604_amyloidosis0.96356012
69MP0008057_abnormal_DNA_replication0.94035111
70MP0002998_abnormal_bone_remodeling0.93611026
71MP0003075_altered_response_to0.92679018
72MP0005076_abnormal_cell_differentiation0.92488261
73MP0010352_gastrointestinal_tract_polyps0.92009684
74MP0002019_abnormal_tumor_incidence0.89879787
75MP0003690_abnormal_glial_cell0.89393906
76MP0009840_abnormal_foam_cell0.89358318
77MP0009763_increased_sensitivity_to0.87335621
78MP0005166_decreased_susceptibility_to0.85677889
79MP0002138_abnormal_hepatobiliary_system0.77654329
80MP0003828_pulmonary_edema0.77524088
81MP0000015_abnormal_ear_pigmentation0.75449397
82MP0003045_fibrosis0.75369927
83MP0003566_abnormal_cell_adhesion0.73358587
84MP0002277_abnormal_respiratory_mucosa0.72011000
85MP0005390_skeleton_phenotype0.69745908
86MP0003221_abnormal_cardiomyocyte_apopto0.69268810
87MP0005023_abnormal_wound_healing0.69225289
88MP0000249_abnormal_blood_vessel0.65618744
89MP0003693_abnormal_embryo_hatching0.65261015
90MP0001663_abnormal_digestive_system0.64755085
91MP0005075_abnormal_melanosome_morpholog0.64498390
92MP0003806_abnormal_nucleotide_metabolis0.64287621
93MP0002132_abnormal_respiratory_system0.61193118
94MP0000371_diluted_coat_color0.60470414
95MP0003795_abnormal_bone_structure0.60230432
96MP0002877_abnormal_melanocyte_morpholog0.59865553
97MP0004782_abnormal_surfactant_physiolog0.59811689
98MP0008874_decreased_physiological_sensi0.56858375
99MP0003077_abnormal_cell_cycle0.56524476
100MP0002136_abnormal_kidney_physiology0.55755994
101MP0010094_abnormal_chromosome_stability0.55620595
102MP0000609_abnormal_liver_physiology0.54926243
103MP0008004_abnormal_stomach_pH0.54478711
104MP0003091_abnormal_cell_migration0.53757942
105MP0003656_abnormal_erythrocyte_physiolo0.53695199
106MP0009765_abnormal_xenobiotic_induced0.53623412
107MP0002095_abnormal_skin_pigmentation0.51351493
108MP0003453_abnormal_keratinocyte_physiol0.50318284
109MP0000313_abnormal_cell_death0.50110355
110MP0008873_increased_physiological_sensi0.49790373
111MP0002693_abnormal_pancreas_physiology0.49195577
112MP0000598_abnormal_liver_morphology0.47946808
113MP0009115_abnormal_fat_cell0.45890727
114MP0005164_abnormal_response_to0.44193955
115MP0001986_abnormal_taste_sensitivity0.42835165

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.21153067
2Eczematoid dermatitis (HP:0000976)6.16965458
3Recurrent bacterial skin infections (HP:0005406)5.47938347
4Myositis (HP:0100614)4.64969485
5Recurrent fungal infections (HP:0002841)4.51073225
6Recurrent gram-negative bacterial infections (HP:0005420)4.50317482
7Elevated erythrocyte sedimentation rate (HP:0003565)4.50138288
8Recurrent viral infections (HP:0004429)4.15145152
9Mediastinal lymphadenopathy (HP:0100721)4.15034741
10Chronic otitis media (HP:0000389)4.01784994
11Abnormality of macrophages (HP:0004311)3.98403420
12Stomatitis (HP:0010280)3.97592239
13Chronic obstructive pulmonary disease (HP:0006510)3.90494649
14Obstructive lung disease (HP:0006536)3.90494649
15Recurrent skin infections (HP:0001581)3.88693045
16IgM deficiency (HP:0002850)3.87203023
17Orchitis (HP:0100796)3.79939464
18Retrobulbar optic neuritis (HP:0100654)3.76386026
19Optic neuritis (HP:0100653)3.76386026
20Vasculitis (HP:0002633)3.62974191
21Meningitis (HP:0001287)3.61918614
22Recurrent bronchitis (HP:0002837)3.58651358
23Recurrent cutaneous fungal infections (HP:0011370)3.55387945
24Chronic mucocutaneous candidiasis (HP:0002728)3.55387945
25Abnormality of T cell number (HP:0011839)3.44853167
26T lymphocytopenia (HP:0005403)3.40049430
27Cellulitis (HP:0100658)3.39554524
28Autoimmune thrombocytopenia (HP:0001973)3.36506923
29Abnormal delayed hypersensitivity skin test (HP:0002963)3.34147397
30Gingivitis (HP:0000230)3.28390091
31Abnormality of T cells (HP:0002843)3.25799331
32Vacuolated lymphocytes (HP:0001922)3.11600134
33Pustule (HP:0200039)3.06783391
34Panhypogammaglobulinemia (HP:0003139)3.06526327
35Increased cerebral lipofuscin (HP:0011813)3.04212035
36Spontaneous hematomas (HP:0007420)3.02788308
37Abnormality of T cell physiology (HP:0011840)3.00950358
38Inflammation of the large intestine (HP:0002037)3.00498995
39Thrombocytosis (HP:0001894)2.99103337
40Nasal polyposis (HP:0100582)2.97479495
41Agammaglobulinemia (HP:0004432)2.94220440
42Pulmonary infiltrates (HP:0002113)2.93984511
43Periodontitis (HP:0000704)2.90863627
44Lymphopenia (HP:0001888)2.89754144
45Gastrointestinal inflammation (HP:0004386)2.88817073
46Increased neuronal autofluorescent lipopigment (HP:0002074)2.87585421
47Autoimmune hemolytic anemia (HP:0001890)2.86876316
48Abnormality of cells of the lymphoid lineage (HP:0012140)2.86046469
49Interstitial pulmonary disease (HP:0006530)2.84384088
50Arterial thrombosis (HP:0004420)2.83496462
51Leukocytosis (HP:0001974)2.78857714
52Colitis (HP:0002583)2.76069920
53Gastrointestinal stroma tumor (HP:0100723)2.73116210
54Keratoconjunctivitis sicca (HP:0001097)2.68928444
55Eosinophilia (HP:0001880)2.67928269
56Hemoptysis (HP:0002105)2.66216607
57Osteomyelitis (HP:0002754)2.65631659
58Abnormality of the nasal mucosa (HP:0000433)2.64537996
59IgA deficiency (HP:0002720)2.62665074
60IgG deficiency (HP:0004315)2.60329691
61Encephalitis (HP:0002383)2.58502247
62Pulmonary embolism (HP:0002204)2.56821964
63Chronic diarrhea (HP:0002028)2.52624461
64Recurrent sinusitis (HP:0011108)2.51595805
65Keratoconjunctivitis (HP:0001096)2.50704715
66Recurrent pneumonia (HP:0006532)2.50358476
67Petechiae (HP:0000967)2.50197168
68Urticaria (HP:0001025)2.48619406
69Systemic lupus erythematosus (HP:0002725)2.47956037
70Abnormality of the prostate (HP:0008775)2.46940116
71Granulocytopenia (HP:0001913)2.46923377
72Anorexia (HP:0002039)2.45621332
73Gangrene (HP:0100758)2.44506857
74Thyroiditis (HP:0100646)2.42375404
75Severe combined immunodeficiency (HP:0004430)2.42167381
76Abnormality of eosinophils (HP:0001879)2.41914940
77Combined immunodeficiency (HP:0005387)2.41104527
78Increased IgM level (HP:0003496)2.36686792
79Increased IgE level (HP:0003212)2.36470891
80Gingival bleeding (HP:0000225)2.34823244
81Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.34789829
82Viral hepatitis (HP:0006562)2.34668300
83Abnormality of B cell number (HP:0010975)2.33395741
84B lymphocytopenia (HP:0010976)2.33395741
85Hypergammaglobulinemia (HP:0010702)2.32003241
86Chest pain (HP:0100749)2.31888041
87Recurrent lower respiratory tract infections (HP:0002783)2.29576325
88Epistaxis (HP:0000421)2.25798186
89Abnormality of liposaccharide metabolism (HP:0010968)2.25586284
90Emphysema (HP:0002097)2.22672307
91Amaurosis fugax (HP:0100576)2.21992552
92Gastrointestinal infarctions (HP:0005244)2.21465819
93Papilloma (HP:0012740)2.20319336
94Verrucae (HP:0200043)2.20319336
95Basal ganglia calcification (HP:0002135)2.18722689
96Skin ulcer (HP:0200042)2.18356337
97Hypochromic anemia (HP:0001931)2.17578963
98Lymphoma (HP:0002665)2.17383134
99Hematochezia (HP:0002573)2.17189142
100Joint swelling (HP:0001386)2.16643210
101Abnormality of the fingertips (HP:0001211)2.16201395
102Dysostosis multiplex (HP:0000943)2.15905770
103Prolonged bleeding time (HP:0003010)2.15828940
104Episodic fever (HP:0001954)2.14607688
105Glomerulopathy (HP:0100820)2.14171869
106Acute hepatic failure (HP:0006554)2.09427268
107Skin rash (HP:0000988)2.08803302
108Chronic sinusitis (HP:0011109)2.08027726
109Restrictive lung disease (HP:0002091)2.06671971
110Abnormality of the peritoneum (HP:0002585)2.06296505
111Myocardial infarction (HP:0001658)2.04749488
112Slow saccadic eye movements (HP:0000514)2.03840295
113Amyloidosis (HP:0011034)2.02406087
114Abnormality of the pleura (HP:0002103)2.02047637
115Sepsis (HP:0100806)2.01405700
116Hepatosplenomegaly (HP:0001433)2.00925863
117Abnormality of glycolipid metabolism (HP:0010969)2.00758706
118Abnormality of glycosphingolipid metabolism (HP:0004343)2.00758706
119Abnormality of the endocardium (HP:0004306)1.98790109
120Polyneuropathy (HP:0001271)1.98425950

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.11145468
2TXK3.60114168
3MAP3K142.98745823
4BLK2.96720942
5IRAK42.93703963
6TYK22.83341336
7PRPF4B2.78930874
8JAK32.76575192
9ZAP702.52287403
10TBK12.44634417
11KIT2.37849656
12STK102.35766603
13BTK2.17347402
14ITK2.11368116
15IKBKE2.09753817
16TEC2.03832969
17RIPK42.03553762
18SYK1.93521627
19JAK11.91814769
20CSF1R1.85436379
21IKBKB1.79198441
22CSK1.76536028
23IRAK31.72475519
24HCK1.62860242
25ERN11.60537229
26LCK1.55804889
27MAP2K31.54638870
28FES1.53448939
29EPHB11.50599746
30FGFR41.46105416
31GRK61.43846198
32BMPR21.39682504
33TAOK31.38986812
34LRRK21.31828621
35MAP3K131.31680630
36LYN1.28930432
37CLK11.28303527
38FGFR31.27348321
39TGFBR21.26729925
40PIM11.13047458
41CHUK1.12304556
42RPS6KA41.07220954
43MAP3K11.05272550
44EEF2K1.04509031
45SMG11.04136220
46KSR21.02546953
47TESK20.99530419
48JAK20.97599141
49PIM20.96797573
50NEK90.94197635
51MARK30.92919659
52PIK3CG0.92856822
53YES10.90786225
54KDR0.88859050
55MST40.87132554
56TAOK20.85606856
57PRKCQ0.82987082
58MAP3K100.82332730
59NME20.80680805
60TRIB30.80578011
61NLK0.79075364
62TRPM70.77447547
63SIK20.77012229
64PKN20.75836726
65EPHA30.73647937
66STK40.69602482
67FLT30.69394197
68FGR0.66824689
69CAMKK20.66311286
70MAPK120.66238091
71IRAK20.64690614
72CDK120.60043338
73TTN0.59877601
74MATK0.59162570
75PDPK10.58984280
76MAPK70.57404294
77MAP3K110.56717400
78CDK40.55092957
79MARK20.55074222
80SIK30.54518033
81MAP3K80.53629771
82GRK70.53058309
83MAP3K30.52316960
84PTK60.52248329
85PRKCH0.50844235
86HIPK20.50058691
87CDK190.48860709
88CAMKK10.48787554
89RAF10.48633462
90MAPKAPK20.48527379
91CDC42BPA0.47380524
92ALK0.47343203
93ABL10.46757919
94CDK60.46727352
95EGFR0.46591826
96MAP3K20.46131693
97NEK20.45347832
98MAP3K60.43964844
99TGFBR10.43054091
100MAP3K120.42875621
101SCYL20.40615007
102SGK30.39978100
103PDK10.39439649
104MAP3K50.39068168
105TAOK10.38655379
106TNK20.37821937
107IRAK10.36753111
108* PRKCD0.36398094
109RPS6KA60.36271689
110PASK0.35306418
111MAPK40.33819613
112CAMK1D0.33025658
113FYN0.32692835
114PAK40.31169302
115RET0.30818830
116MAP2K60.30705326
117TESK10.30681926
118MAP3K70.30309149
119PRKD20.30302839
120ACVR1B0.28351732
121IGF1R0.27782957
122MAPK110.25733498
123ATR0.25699293
124RPS6KL10.24151575
125RPS6KC10.24151575
126CDC70.23685898
127STK240.22193676
128EIF2AK20.21944069

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.28602746
2Leishmaniasis_Homo sapiens_hsa051403.16515392
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.69431726
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.60794470
5Allograft rejection_Homo sapiens_hsa053302.50885317
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.47830489
7B cell receptor signaling pathway_Homo sapiens_hsa046622.46942419
8Osteoclast differentiation_Homo sapiens_hsa043802.44460041
9Graft-versus-host disease_Homo sapiens_hsa053322.43219654
10Measles_Homo sapiens_hsa051622.41857853
11Staphylococcus aureus infection_Homo sapiens_hsa051502.28104860
12Antigen processing and presentation_Homo sapiens_hsa046122.20007106
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.19388865
14Toll-like receptor signaling pathway_Homo sapiens_hsa046202.15975943
15T cell receptor signaling pathway_Homo sapiens_hsa046601.97352994
16Hematopoietic cell lineage_Homo sapiens_hsa046401.94064897
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.84983048
18Legionellosis_Homo sapiens_hsa051341.83544179
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.80562072
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.77240220
21Tuberculosis_Homo sapiens_hsa051521.75564341
22Pertussis_Homo sapiens_hsa051331.75085253
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.68984677
24Herpes simplex infection_Homo sapiens_hsa051681.67044203
25Asthma_Homo sapiens_hsa053101.64578294
26Jak-STAT signaling pathway_Homo sapiens_hsa046301.61698123
27Toxoplasmosis_Homo sapiens_hsa051451.60710602
28Influenza A_Homo sapiens_hsa051641.58568810
29Shigellosis_Homo sapiens_hsa051311.53849686
30Malaria_Homo sapiens_hsa051441.53132063
31Viral myocarditis_Homo sapiens_hsa054161.50080609
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.48906774
33TNF signaling pathway_Homo sapiens_hsa046681.46482737
34Autoimmune thyroid disease_Homo sapiens_hsa053201.44407533
35Chemokine signaling pathway_Homo sapiens_hsa040621.44258246
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.42621989
37Apoptosis_Homo sapiens_hsa042101.40150776
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.34930177
39Hepatitis B_Homo sapiens_hsa051611.34329495
40Type I diabetes mellitus_Homo sapiens_hsa049401.30857244
41Salmonella infection_Homo sapiens_hsa051321.27174717
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.25417949
43Lysosome_Homo sapiens_hsa041421.23573405
44Other glycan degradation_Homo sapiens_hsa005111.23157669
45Glycosaminoglycan degradation_Homo sapiens_hsa005311.22210682
46Acute myeloid leukemia_Homo sapiens_hsa052211.15585136
47Rheumatoid arthritis_Homo sapiens_hsa053231.09274821
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02238328
49DNA replication_Homo sapiens_hsa030300.98941314
50Pancreatic cancer_Homo sapiens_hsa052120.96794708
51Chronic myeloid leukemia_Homo sapiens_hsa052200.96425227
52Phagosome_Homo sapiens_hsa041450.93530338
53Hepatitis C_Homo sapiens_hsa051600.93300279
54Epstein-Barr virus infection_Homo sapiens_hsa051690.92592689
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90579905
56Platelet activation_Homo sapiens_hsa046110.88390352
57Base excision repair_Homo sapiens_hsa034100.83910174
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83692959
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81135652
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79939397
61African trypanosomiasis_Homo sapiens_hsa051430.79102847
62Viral carcinogenesis_Homo sapiens_hsa052030.77441068
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.71638166
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71461120
65HTLV-I infection_Homo sapiens_hsa051660.71045421
66Prolactin signaling pathway_Homo sapiens_hsa049170.67616440
67Renal cell carcinoma_Homo sapiens_hsa052110.67335370
68Caffeine metabolism_Homo sapiens_hsa002320.66051564
69VEGF signaling pathway_Homo sapiens_hsa043700.56815531
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56280240
71Small cell lung cancer_Homo sapiens_hsa052220.54654409
72Mismatch repair_Homo sapiens_hsa034300.52688997
73p53 signaling pathway_Homo sapiens_hsa041150.52318363
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50832640
75Non-small cell lung cancer_Homo sapiens_hsa052230.50415741
76Endometrial cancer_Homo sapiens_hsa052130.43936316
77Non-homologous end-joining_Homo sapiens_hsa034500.43704384
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.43641167
79Dorso-ventral axis formation_Homo sapiens_hsa043200.42922297
80mTOR signaling pathway_Homo sapiens_hsa041500.42795452
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41747697
82Amoebiasis_Homo sapiens_hsa051460.41447865
83Endocytosis_Homo sapiens_hsa041440.40891931
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.39670136
85HIF-1 signaling pathway_Homo sapiens_hsa040660.39366070
86GnRH signaling pathway_Homo sapiens_hsa049120.38909858
87Colorectal cancer_Homo sapiens_hsa052100.38127886
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37504276
89Choline metabolism in cancer_Homo sapiens_hsa052310.35127288
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34998640
91Pentose phosphate pathway_Homo sapiens_hsa000300.34097418
92Notch signaling pathway_Homo sapiens_hsa043300.33828584
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33620998
94Homologous recombination_Homo sapiens_hsa034400.32280798
95Type II diabetes mellitus_Homo sapiens_hsa049300.31511735
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.30866442
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30736779
98Insulin resistance_Homo sapiens_hsa049310.27657983
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.26969497
100Glioma_Homo sapiens_hsa052140.26293162
101MicroRNAs in cancer_Homo sapiens_hsa052060.25913227
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.25179784
103Complement and coagulation cascades_Homo sapiens_hsa046100.25147964
104ErbB signaling pathway_Homo sapiens_hsa040120.24369010
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23446376
106FoxO signaling pathway_Homo sapiens_hsa040680.23403786
107Bladder cancer_Homo sapiens_hsa052190.21174444
108One carbon pool by folate_Homo sapiens_hsa006700.19960069
109Proteoglycans in cancer_Homo sapiens_hsa052050.19771578
110Systemic lupus erythematosus_Homo sapiens_hsa053220.18314911
111MAPK signaling pathway_Homo sapiens_hsa040100.17989106
112Cell cycle_Homo sapiens_hsa041100.16388104
113Prostate cancer_Homo sapiens_hsa052150.15623438
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.15573500
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.15201126
116Inositol phosphate metabolism_Homo sapiens_hsa005620.15067887

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