LCE6A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organismal water homeostasis (GO:0050891)8.08630946
2long-chain fatty acid biosynthetic process (GO:0042759)7.90865946
3regulation of transforming growth factor beta1 production (GO:0032908)7.66390574
4regulation of cell proliferation involved in kidney development (GO:1901722)7.15712385
5positive regulation of glomerulus development (GO:0090193)7.07868837
6sphingoid metabolic process (GO:0046519)7.01989119
7water homeostasis (GO:0030104)6.83869428
8detection of bacterium (GO:0016045)6.81741716
9keratinocyte differentiation (GO:0030216)6.41656451
10fatty acid elongation (GO:0030497)6.33012747
11detection of other organism (GO:0098543)6.25973744
12regulation of ruffle assembly (GO:1900027)6.10877014
13hemidesmosome assembly (GO:0031581)6.02975209
14glucosamine-containing compound catabolic process (GO:1901072)6.01060247
15skin morphogenesis (GO:0043589)5.97353875
16keratinocyte proliferation (GO:0043616)5.48332085
17sphingosine metabolic process (GO:0006670)5.31481807
18gap junction assembly (GO:0016264)5.30327415
19regulation of natural killer cell differentiation (GO:0032823)5.28972822
20peptide cross-linking (GO:0018149)5.23008701
21epidermal cell differentiation (GO:0009913)5.10840652
22linoleic acid metabolic process (GO:0043651)5.09586501
23positive regulation of cellular amide metabolic process (GO:0034250)4.93420820
24transepithelial transport (GO:0070633)4.86542923
25negative regulation of interferon-gamma production (GO:0032689)4.85463275
26bundle of His cell to Purkinje myocyte communication (GO:0086069)4.83590340
27diol metabolic process (GO:0034311)4.80356972
28positive regulation of interleukin-8 secretion (GO:2000484)4.80204353
29molting cycle (GO:0042303)4.76725786
30hair cycle (GO:0042633)4.76725786
31epidermis development (GO:0008544)4.73849189
32intermediate filament cytoskeleton organization (GO:0045104)4.73127103
33chemical homeostasis within a tissue (GO:0048875)4.63938429
34long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.62833757
35intermediate filament-based process (GO:0045103)4.58092932
36phosphatidylinositol acyl-chain remodeling (GO:0036149)4.56852456
37regulation of glomerulus development (GO:0090192)4.51235973
38phospholipid scrambling (GO:0017121)4.49313018
39regulation of hypersensitivity (GO:0002883)4.41997902
40surfactant homeostasis (GO:0043129)4.37805559
41phospholipid efflux (GO:0033700)4.30103798
42positive regulation of transforming growth factor beta production (GO:0071636)4.11867388
43negative regulation of interleukin-17 production (GO:0032700)4.06875858
44intermediate filament organization (GO:0045109)4.06004199
45viral transcription (GO:0019083)4.04028704
46prostanoid biosynthetic process (GO:0046457)3.96653023
47prostaglandin biosynthetic process (GO:0001516)3.96653023
48phosphatidylserine acyl-chain remodeling (GO:0036150)3.94025441
49lipoxygenase pathway (GO:0019372)3.91995958
50fatty-acyl-CoA metabolic process (GO:0035337)3.91010081
51phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.89934554
52arachidonic acid secretion (GO:0050482)3.87510049
53icosanoid secretion (GO:0032309)3.87510049
54cyclooxygenase pathway (GO:0019371)3.85885455
55ceramide biosynthetic process (GO:0046513)3.84429236
56translational termination (GO:0006415)3.79416896
57G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.76288812
58copper ion transport (GO:0006825)3.75314347
59phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.74937393
60polarized epithelial cell differentiation (GO:0030859)3.74811445
61defense response to Gram-negative bacterium (GO:0050829)3.71729825
62defense response to fungus (GO:0050832)3.70286902
63regulation of interleukin-8 secretion (GO:2000482)3.67253667
64ribosomal small subunit biogenesis (GO:0042274)3.64384725
65negative regulation of acute inflammatory response (GO:0002674)3.63890606
66positive regulation of cholesterol efflux (GO:0010875)3.57209343
67detection of external biotic stimulus (GO:0098581)3.55872008
68lateral sprouting from an epithelium (GO:0060601)3.52139482
69epithelium development (GO:0060429)3.51154749
70ectoderm development (GO:0007398)3.49944376
71phosphatidylcholine acyl-chain remodeling (GO:0036151)3.45260566
72fatty acid derivative transport (GO:1901571)3.36416631
73icosanoid transport (GO:0071715)3.36416631
74cardiac right ventricle morphogenesis (GO:0003215)3.35626156
75antimicrobial humoral response (GO:0019730)3.35220395
76positive regulation of cholesterol transport (GO:0032376)3.32821033
77positive regulation of sterol transport (GO:0032373)3.32821033
78eyelid development in camera-type eye (GO:0061029)3.31631100
79unsaturated fatty acid biosynthetic process (GO:0006636)3.28459740
80positive regulation of collagen biosynthetic process (GO:0032967)3.27411806
81positive regulation of p38MAPK cascade (GO:1900745)3.26421317
82long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.25570253
83regulation of keratinocyte differentiation (GO:0045616)3.24127640
84phosphatidylserine metabolic process (GO:0006658)3.23538062
85positive regulation of epidermis development (GO:0045684)3.22390872
86regulation of axon regeneration (GO:0048679)3.19438043
87regulation of neuron projection regeneration (GO:0070570)3.19438043
88regulation of phospholipase A2 activity (GO:0032429)3.18888673
89keratinocyte development (GO:0003334)3.16123370
90positive regulation of interleukin-4 production (GO:0032753)3.14746739
91negative regulation of keratinocyte proliferation (GO:0010839)3.14015272
92viral life cycle (GO:0019058)3.13731579
93positive regulation of collagen metabolic process (GO:0010714)3.12938046
94regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.11664853
95negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.11083109
96prostanoid metabolic process (GO:0006692)3.07635853
97prostaglandin metabolic process (GO:0006693)3.07635853
98cardiolipin metabolic process (GO:0032048)3.05191595
99positive regulation of monocyte chemotaxis (GO:0090026)3.04635688
100interferon-gamma secretion (GO:0072643)3.03453244
101glutathione biosynthetic process (GO:0006750)3.02043680
102detection of biotic stimulus (GO:0009595)3.01957284
103negative regulation of stress fiber assembly (GO:0051497)3.00968024
104negative regulation of interleukin-2 production (GO:0032703)2.99690279
105translational elongation (GO:0006414)2.97656987
106fatty-acyl-CoA biosynthetic process (GO:0046949)2.96518465
107positive regulation of epidermal cell differentiation (GO:0045606)2.95621148
108negative regulation of T cell mediated immunity (GO:0002710)2.94762777
109SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.94187003
110positive regulation of humoral immune response (GO:0002922)2.93307016
111epithelial cell differentiation involved in prostate gland development (GO:0060742)2.91077141
112protein targeting to ER (GO:0045047)2.90902196
113cotranslational protein targeting to membrane (GO:0006613)2.89880780
114establishment of planar polarity (GO:0001736)2.86948560
115establishment of tissue polarity (GO:0007164)2.86948560
116cellular response to antibiotic (GO:0071236)2.85450136
117cellular protein complex disassembly (GO:0043624)2.85297096
118sphingolipid biosynthetic process (GO:0030148)2.84897904
119regulation of epidermis development (GO:0045682)2.84595539
120regulation of collagen biosynthetic process (GO:0032965)2.83905689
121establishment of protein localization to endoplasmic reticulum (GO:0072599)2.83070885
122regulation of transforming growth factor beta production (GO:0071634)2.79795638
123phospholipid catabolic process (GO:0009395)2.79559104
124intestinal epithelial cell development (GO:0060576)2.78072170
125calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.74898792
126positive regulation of T cell chemotaxis (GO:0010820)2.74850099
127regulation of T cell chemotaxis (GO:0010819)2.74850099
128phosphatidylglycerol metabolic process (GO:0046471)2.73609238
129protein localization to endoplasmic reticulum (GO:0070972)2.71916985
130cellular response to arsenic-containing substance (GO:0071243)2.71133865
131regulation of natural killer cell activation (GO:0032814)2.71086715
132nonribosomal peptide biosynthetic process (GO:0019184)2.69798404
133regulation of keratinocyte proliferation (GO:0010837)2.69065497
134regulation of protein localization to cell surface (GO:2000008)2.68938796
135hair follicle morphogenesis (GO:0031069)2.67680045
136regulation of cholesterol homeostasis (GO:2000188)2.67462702
137alditol phosphate metabolic process (GO:0052646)2.63278555
138regulation of epidermal cell differentiation (GO:0045604)2.52411341
139positive regulation of keratinocyte differentiation (GO:0045618)2.45662500
140sequestering of metal ion (GO:0051238)2.45008701
141response to fungus (GO:0009620)2.44095434
142epithelial cell differentiation (GO:0030855)2.40058366
143regulation of cholesterol efflux (GO:0010874)2.38323585
144regulation of cellular amide metabolic process (GO:0034248)2.37938270
145ventricular cardiac muscle cell action potential (GO:0086005)2.37761013
146polyol transport (GO:0015791)2.35482038
147epithelial cell maturation (GO:0002070)2.33719456
148regulation of p38MAPK cascade (GO:1900744)2.33173661
149one-carbon compound transport (GO:0019755)2.32727241
150regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.27945278
151positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.27945278
152defense response to Gram-positive bacterium (GO:0050830)2.26766966
153establishment of skin barrier (GO:0061436)13.9717390
154regulation of water loss via skin (GO:0033561)12.4474976
155desmosome organization (GO:0002934)12.0617511
156* keratinization (GO:0031424)11.4302489

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.98989568
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.63026958
3STAT6_21828071_ChIP-Seq_BEAS2B_Human3.39934144
4P63_26484246_Chip-Seq_KERATINOCYTES_Human3.33546245
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.76924387
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.75353903
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.53866648
8SOX9_24532713_ChIP-Seq_HFSC_Mouse2.51800360
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.42679564
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.38342777
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.04066691
12TP63_17297297_ChIP-ChIP_HaCaT_Human12.4355164
13FOXO3_23340844_ChIP-Seq_DLD1_Human1.89270844
14ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.84584455
15TCF4_18268006_ChIP-ChIP_LS174T_Human1.83449123
16EGR1_19032775_ChIP-ChIP_M12_Human1.77611011
17SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.76719453
18SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.76719453
19SOX2_20726797_ChIP-Seq_SW620_Human1.71900278
20TP63_23658742_ChIP-Seq_EP156T_Human1.62562188
21ZNF217_24962896_ChIP-Seq_MCF-7_Human1.48816400
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.40007818
23RUNX1_27514584_Chip-Seq_MCF-7_Human1.38487063
24CJUN_26792858_Chip-Seq_BT549_Human1.37019461
25TP63_22573176_ChIP-Seq_HFKS_Human1.36765697
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34481754
27* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.32787130
28SRY_22984422_ChIP-ChIP_TESTIS_Rat1.32754258
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.32653297
30TP53_18474530_ChIP-ChIP_U2OS_Human1.30809930
31TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29530286
32KLF5_25053715_ChIP-Seq_YYC3_Human1.29251517
33ERG_20517297_ChIP-Seq_VCAP_Human1.25962385
34* GATA6_21074721_ChIP-Seq_CACO-2_Human1.24399947
35GATA4_25053715_ChIP-Seq_YYC3_Human1.24161571
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.24143470
37GATA3_24758297_ChIP-Seq_MCF-7_Human1.21658730
38CEBPB_22108803_ChIP-Seq_LS180_Human1.17909573
39CTCF_27219007_Chip-Seq_Bcells_Human1.15576647
40ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14238360
41EZH2_27294783_Chip-Seq_ESCs_Mouse1.13274897
42ZNF263_19887448_ChIP-Seq_K562_Human1.12621615
43BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11383309
44ATF3_27146783_Chip-Seq_COLON_Human1.10508391
45BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.06666588
46RXR_22108803_ChIP-Seq_LS180_Human1.05623675
47NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05078837
48NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05078837
49AR_21572438_ChIP-Seq_LNCaP_Human1.04679206
50FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.04413590
51P53_21459846_ChIP-Seq_SAOS-2_Human1.02754663
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01834847
53P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.01483399
54SA1_27219007_Chip-Seq_ERYTHROID_Human1.00381701
55SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.99619129
56BCAT_22108803_ChIP-Seq_LS180_Human0.98786793
57STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.96874522
58SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.96422144
59SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96142186
60LXR_22292898_ChIP-Seq_THP-1_Human0.95982969
61AHR_22903824_ChIP-Seq_MCF-7_Human0.94718348
62* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.94416731
63EED_16625203_ChIP-ChIP_MESCs_Mouse0.93351901
64KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93336204
65AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.93328531
66PPARA_22158963_ChIP-Seq_LIVER_Mouse0.92163725
67KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91914651
68TP53_20018659_ChIP-ChIP_R1E_Mouse0.91898936
69PPAR_26484153_Chip-Seq_NCI-H1993_Human0.91792502
70IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.91544245
71RACK7_27058665_Chip-Seq_MCF-7_Human0.91037083
72DNAJC2_21179169_ChIP-ChIP_NT2_Human0.89701177
73ARNT_22903824_ChIP-Seq_MCF-7_Human0.89597931
74LXR_22158963_ChIP-Seq_LIVER_Mouse0.89188138
75UBF1/2_26484160_Chip-Seq_HMECs_Human0.88931132
76FOXM1_26456572_ChIP-Seq_MCF-7_Human0.88539410
77SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.88024283
78ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.88017687
79EZH2_27304074_Chip-Seq_ESCs_Mouse0.87440052
80JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86073730
81GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.85782865
82SA1_27219007_Chip-Seq_Bcells_Human0.85738443
83VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.85695252
84CTCF_20526341_ChIP-Seq_ESCs_Human0.85568801
85SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.85101210
86TP53_16413492_ChIP-PET_HCT116_Human0.85081178
87* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.85027143
88BMI1_23680149_ChIP-Seq_NPCS_Mouse0.84347114
89PIAS1_25552417_ChIP-Seq_VCAP_Human0.82883040
90P53_22127205_ChIP-Seq_FIBROBLAST_Human0.82683605
91RARG_19884340_ChIP-ChIP_MEFs_Mouse0.82679714
92AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82138234
93ESR1_20079471_ChIP-ChIP_T-47D_Human0.81668545
94ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.81222977
95TCF4_22108803_ChIP-Seq_LS180_Human0.80380584
96ZFP57_27257070_Chip-Seq_ESCs_Mouse0.80356374
97SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.80089558
98ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.79798767
99Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.79781105
100CBX2_22325352_ChIP-Seq_293T-Rex_Human0.78674253
101CDX2_20551321_ChIP-Seq_CACO-2_Human0.78561652
102JARID2_20075857_ChIP-Seq_MESCs_Mouse0.78215910
103SOX2_27498859_Chip-Seq_STOMACH_Mouse0.78193118
104GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.77666910
105FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.76484545
106JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76357835
107* RBPJ_21746931_ChIP-Seq_IB4_Human0.75849135
108PCGF2_27294783_Chip-Seq_NPCs_Mouse0.75360602
109CDX2_22108803_ChIP-Seq_LS180_Human0.74834869
110CLOCK_20551151_ChIP-Seq_293T_Human0.74609510
111MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.74176587
112PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.73768405
113* HNFA_21074721_ChIP-Seq_CACO-2_Human0.73727150
114JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.73523553
115HTT_18923047_ChIP-ChIP_STHdh_Human0.73281458
116GATA6_25053715_ChIP-Seq_YYC3_Human0.73248369
117YY1_22570637_ChIP-Seq_MALME-3M_Human0.72772652
118FOXA1_25552417_ChIP-Seq_VCAP_Human0.72577047
119CSB_26484114_Chip-Seq_FIBROBLAST_Human0.72327703
120FOXH1_21741376_ChIP-Seq_ESCs_Human0.72035649
121NCOR_22424771_ChIP-Seq_293T_Human0.71958390
122E2F1_20622854_ChIP-Seq_HELA_Human0.70663849
123HIF1A_21447827_ChIP-Seq_MCF-7_Human0.70458006
124RNF2_18974828_ChIP-Seq_MESCs_Mouse0.69591288
125EZH2_18974828_ChIP-Seq_MESCs_Mouse0.69591288
126AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.69451430
127PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.69336696
128PHF8_20622853_ChIP-Seq_HELA_Human0.68853264
129CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.68621607
130RXR_22158963_ChIP-Seq_LIVER_Mouse0.68614774
131ERG_21242973_ChIP-ChIP_JURKAT_Human0.68425159
132SMAD4_21799915_ChIP-Seq_A2780_Human0.68045916
133MTF2_20144788_ChIP-Seq_MESCs_Mouse0.67788214
134FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.67580332
135BCOR_27268052_Chip-Seq_Bcells_Human0.66565042
136PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.65840664
137SMAD4_21741376_ChIP-Seq_ESCs_Human0.65519532
138GATA1_22025678_ChIP-Seq_K562_Human0.65465404
139POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.62766807
140TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.62766807
141ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.62706650
142FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.60935892

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier8.57185795
2MP0010234_abnormal_vibrissa_follicle7.77057177
3MP0003941_abnormal_skin_development5.55384465
4MP0005275_abnormal_skin_tensile5.41505270
5MP0005501_abnormal_skin_physiology4.96083060
6MP0004381_abnormal_hair_follicle4.30006097
7MP0005451_abnormal_body_composition4.07002307
8MP0010678_abnormal_skin_adnexa3.85395673
9MP0000383_abnormal_hair_follicle3.46062599
10MP0002060_abnormal_skin_morphology3.34387445
11MP0010771_integument_phenotype3.12599443
12MP0001216_abnormal_epidermal_layer3.10946090
13MP0000647_abnormal_sebaceous_gland2.97709661
14MP0000579_abnormal_nail_morphology2.92723706
15MP0002254_reproductive_system_inflammat2.78266715
16MP0003191_abnormal_cellular_cholesterol2.63103923
17MP0002098_abnormal_vibrissa_morphology2.61888675
18MP0004947_skin_inflammation2.44217750
19MP0003453_abnormal_keratinocyte_physiol2.30542152
20MP0001188_hyperpigmentation2.12417563
21MP0004885_abnormal_endolymph2.05482385
22MP0000377_abnormal_hair_follicle2.04866430
23MP0003878_abnormal_ear_physiology1.99786296
24MP0005377_hearing/vestibular/ear_phenot1.99786296
25MP0000427_abnormal_hair_cycle1.67925761
26MP0000467_abnormal_esophagus_morphology1.66446335
27MP0001191_abnormal_skin_condition1.63266156
28MP0009931_abnormal_skin_appearance1.61441864
29MP0004782_abnormal_surfactant_physiolog1.52518859
30MP0003705_abnormal_hypodermis_morpholog1.46524318
31MP0009379_abnormal_foot_pigmentation1.46267497
32MP0004185_abnormal_adipocyte_glucose1.44235894
33MP0003136_yellow_coat_color1.37041465
34MP0000762_abnormal_tongue_morphology1.32672646
35MP0001243_abnormal_dermal_layer1.17237202
36MP0000367_abnormal_coat/_hair1.11937768
37MP0001346_abnormal_lacrimal_gland1.02166216
38MP0003566_abnormal_cell_adhesion1.00001866
39MP0001851_eye_inflammation0.98723802
40MP0003950_abnormal_plasma_membrane0.91206490
41MP0006054_spinal_hemorrhage0.89173007
42MP0002877_abnormal_melanocyte_morpholog0.86378273
43MP0008004_abnormal_stomach_pH0.84145115
44MP0003011_delayed_dark_adaptation0.80591569
45MP0005075_abnormal_melanosome_morpholog0.80050942
46MP0000566_synostosis0.78365967
47MP0001340_abnormal_eyelid_morphology0.76108790
48MP0005174_abnormal_tail_pigmentation0.73224679
49MP0000015_abnormal_ear_pigmentation0.72924286
50MP0002009_preneoplasia0.71310139
51MP0010386_abnormal_urinary_bladder0.69980342
52MP0002234_abnormal_pharynx_morphology0.64464745
53MP0010352_gastrointestinal_tract_polyps0.63610254
54MP0004264_abnormal_extraembryonic_tissu0.63466798
55MP0001784_abnormal_fluid_regulation0.60063101
56MP0005187_abnormal_penis_morphology0.59566702
57MP0000627_abnormal_mammary_gland0.54356715
58MP0004019_abnormal_vitamin_homeostasis0.52421398
59MP0001177_atelectasis0.51503425
60MP0000465_gastrointestinal_hemorrhage0.51066248
61MP0002138_abnormal_hepatobiliary_system0.48980984
62MP0009384_cardiac_valve_regurgitation0.47907792
63MP0003315_abnormal_perineum_morphology0.47041752
64MP0005023_abnormal_wound_healing0.46232515
65MP0005666_abnormal_adipose_tissue0.45564605
66MP0002277_abnormal_respiratory_mucosa0.44514574
67MP0003252_abnormal_bile_duct0.44155362
68MP0003638_abnormal_response/metabolism_0.43553613
69MP0003938_abnormal_ear_development0.42675685
70MP0005076_abnormal_cell_differentiation0.40925566
71MP0005503_abnormal_tendon_morphology0.39685178
72MP0002132_abnormal_respiratory_system0.34777703
73MP0004147_increased_porphyrin_level0.34513393
74MP0002090_abnormal_vision0.33274509
75MP0000538_abnormal_urinary_bladder0.33226002
76MP0003329_amyloid_beta_deposits0.33091758
77MP0000372_irregular_coat_pigmentation0.32258713
78MP0004197_abnormal_fetal_growth/weight/0.31637865
79MP0009672_abnormal_birth_weight0.30986471
80MP0002166_altered_tumor_susceptibility0.30041447
81MP0008789_abnormal_olfactory_epithelium0.29111672
82MP0001853_heart_inflammation0.28228096
83MP0001299_abnormal_eye_distance/0.27670395
84MP0001984_abnormal_olfaction0.27436746
85MP0002177_abnormal_outer_ear0.26194517
86MP0001542_abnormal_bone_strength0.25892283
87MP0009053_abnormal_anal_canal0.25862167
88MP0002006_tumorigenesis0.24590370
89MP0000013_abnormal_adipose_tissue0.24155461
90MP0003195_calcinosis0.23760657
91MP0005248_abnormal_Harderian_gland0.23332468
92MP0009780_abnormal_chondrocyte_physiolo0.23104480
93MP0004043_abnormal_pH_regulation0.23043057
94MP0005375_adipose_tissue_phenotype0.22822282
95MP0002148_abnormal_hypersensitivity_rea0.22621318
96MP0009333_abnormal_splenocyte_physiolog0.22560708
97MP0003763_abnormal_thymus_physiology0.22558924
98MP0002697_abnormal_eye_size0.22517477
99MP0003828_pulmonary_edema0.22148389
100MP0005499_abnormal_olfactory_system0.21136748
101MP0005394_taste/olfaction_phenotype0.21136748
102MP0003755_abnormal_palate_morphology0.21039101
103MP0008961_abnormal_basal_metabolism0.20910531
104MP0000428_abnormal_craniofacial_morphol0.20845177
105MP0000569_abnormal_digit_pigmentation0.20600730
106MP0001666_abnormal_nutrient_absorption0.20537740
107MP0002111_abnormal_tail_morphology0.20450341
108MP0004272_abnormal_basement_membrane0.19973732
109MP0005408_hypopigmentation0.19764737
110MP0000750_abnormal_muscle_regeneration0.19636085
111MP0000613_abnormal_salivary_gland0.19131706
112MP0002163_abnormal_gland_morphology0.18802446
113MP0003221_abnormal_cardiomyocyte_apopto0.18714170
114MP0002233_abnormal_nose_morphology0.18614778
115MP0002095_abnormal_skin_pigmentation0.18592284
116MP0010030_abnormal_orbit_morphology0.17402231
117MP0003385_abnormal_body_wall0.17002634
118MP0005165_increased_susceptibility_to0.16296922
119MP0000432_abnormal_head_morphology0.15842926
120MP0002118_abnormal_lipid_homeostasis0.15434915
121MP0005388_respiratory_system_phenotype0.15209421
122MP0002133_abnormal_respiratory_system0.15209421
123MP0001485_abnormal_pinna_reflex0.15075658
124MP0005193_abnormal_anterior_eye0.14927985
125MP0005409_darkened_coat_color0.14636648
126MP0008875_abnormal_xenobiotic_pharmacok0.13525052
127MP0003724_increased_susceptibility_to0.13331526
128MP0003279_aneurysm0.13191908
129MP0005197_abnormal_uvea_morphology0.11472986
130MP0008569_lethality_at_weaning0.10940732
131MP0005508_abnormal_skeleton_morphology0.10760672
132MP0001186_pigmentation_phenotype0.10613806
133MP0002282_abnormal_trachea_morphology0.10343858
134MP0009115_abnormal_fat_cell0.08401015
135MP0008057_abnormal_DNA_replication0.08375886
136MP0000003_abnormal_adipose_tissue0.08049134

Predicted human phenotypes

RankGene SetZ-score
1Congenital ichthyosiform erythroderma (HP:0007431)9.42408650
2Congenital nonbullous ichthyosiform erythroderma (HP:0007479)9.33119680
3Increased IgE level (HP:0003212)8.79007013
4Abnormality of nail color (HP:0100643)7.18015052
5Hypotrichosis (HP:0001006)7.05120155
6Parakeratosis (HP:0001036)6.84721758
7Onycholysis (HP:0001806)6.66769778
8Oral leukoplakia (HP:0002745)5.82527894
9Erythroderma (HP:0001019)5.30625200
10Corneal erosion (HP:0200020)5.30118813
11Plantar hyperkeratosis (HP:0007556)5.28733476
12Ectropion (HP:0000656)5.15037716
13Right ventricular cardiomyopathy (HP:0011663)5.05384466
14Gangrene (HP:0100758)5.00733337
15Palmoplantar hyperkeratosis (HP:0000972)4.94965833
16Palmar hyperkeratosis (HP:0010765)4.61659471
17Woolly hair (HP:0002224)4.45592758
18Erythema (HP:0010783)4.45394677
19Lip pit (HP:0100267)4.43451739
20Hypohidrosis (HP:0000966)3.94802612
21Fragile nails (HP:0001808)3.89658105
22Milia (HP:0001056)3.65744200
23Pruritus (HP:0000989)3.63005009
24Concave nail (HP:0001598)3.50850577
25Hyporeflexia of lower limbs (HP:0002600)3.50727968
26Absent eyelashes (HP:0000561)3.47316525
27Natal tooth (HP:0000695)3.44113424
28Nail dystrophy (HP:0008404)3.40541831
29Curly hair (HP:0002212)3.38107201
30Conjunctival hamartoma (HP:0100780)3.28067815
31Acanthosis nigricans (HP:0000956)3.27102081
32Pili torti (HP:0003777)3.26892310
33Palmoplantar keratoderma (HP:0000982)3.23749035
34Sparse eyelashes (HP:0000653)3.13300749
35Abnormal blistering of the skin (HP:0008066)3.11933636
36Follicular hyperkeratosis (HP:0007502)3.09296268
37Absent hair (HP:0002298)3.08834886
38Lack of skin elasticity (HP:0100679)3.06447695
39Thick nail (HP:0001805)3.01755253
40Atrophic scars (HP:0001075)2.84656583
41Brittle hair (HP:0002299)2.83791280
42Abnormal hemoglobin (HP:0011902)2.83015778
43Malignant hyperthermia (HP:0002047)2.77970686
44Dehydration (HP:0001944)2.75764596
45Advanced eruption of teeth (HP:0006288)2.74395137
46Hypergammaglobulinemia (HP:0010702)2.73085423
47Sparse scalp hair (HP:0002209)2.71724526
48Selective tooth agenesis (HP:0001592)2.70042021
49Furrowed tongue (HP:0000221)2.63337838
50Ventricular tachycardia (HP:0004756)2.63184118
51Oligodontia (HP:0000677)2.48847997
52Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.48457019
53Distal lower limb muscle weakness (HP:0009053)2.46646438
54Eczematoid dermatitis (HP:0000976)2.42818730
55Paralysis (HP:0003470)2.40152944
56Pustule (HP:0200039)2.35696256
57Dry skin (HP:0000958)2.33379898
58Abnormal hair laboratory examination (HP:0003328)2.31433335
59Abnormality of the salivary glands (HP:0010286)2.30481016
60Slow-growing hair (HP:0002217)2.28393127
61Abnormality of hair growth rate (HP:0011363)2.28393127
62Alopecia of scalp (HP:0002293)2.28057138
63Anhidrosis (HP:0000970)2.27580585
64Laryngomalacia (HP:0001601)2.27096656
65Dry hair (HP:0011359)2.24567793
66Hypoparathyroidism (HP:0000829)2.12468129
67Popliteal pterygium (HP:0009756)2.12212876
68Areflexia of lower limbs (HP:0002522)2.11717599
69Autoamputation (HP:0001218)2.10981965
70Abnormality of placental membranes (HP:0011409)2.07310422
71Amniotic constriction ring (HP:0009775)2.07310422
72Conical tooth (HP:0000698)2.06182761
73Abnormality of the axillary hair (HP:0100134)2.05187694
74Abnormality of secondary sexual hair (HP:0009888)2.05187694
75Sensory axonal neuropathy (HP:0003390)2.02981450
76Villous atrophy (HP:0011473)1.96073701
77Abnormality of small intestinal villus morphology (HP:0011472)1.96073701
78Split foot (HP:0001839)1.90186248
79Hypoplasia of dental enamel (HP:0006297)1.88047284
80Sepsis (HP:0100806)1.86584592
81Urticaria (HP:0001025)1.83234354
82Skin ulcer (HP:0200042)1.80199149
83Hyperhidrosis (HP:0000975)1.79125894
84Chronic bronchitis (HP:0004469)1.77408562
85Duplicated collecting system (HP:0000081)1.76870691
86Septate vagina (HP:0001153)1.76358093
87Corneal dystrophy (HP:0001131)1.75887661
88Reticulocytopenia (HP:0001896)1.75232559
89Abnormality of permanent molar morphology (HP:0011071)1.73543393
90Abnormality of the dental root (HP:0006486)1.73543393
91Taurodontia (HP:0000679)1.73543393
92Melanocytic nevus (HP:0000995)1.72011892
93Depressed nasal tip (HP:0000437)1.71406810
94Anonychia (HP:0001798)1.71193152
95Blepharitis (HP:0000498)1.71161046
96Aplasia cutis congenita (HP:0001057)1.70739892
97Hamartoma of the eye (HP:0010568)1.70215527
98Ankyloglossia (HP:0010296)1.69418658
99Premature skin wrinkling (HP:0100678)1.69282037
100Epidermoid cyst (HP:0200040)1.69084401
101Multifactorial inheritance (HP:0001426)1.68226362
102Nasolacrimal duct obstruction (HP:0000579)1.67766368
103Ventricular fibrillation (HP:0001663)1.66268509
104Fine hair (HP:0002213)1.64127659
105Hypoplastic labia majora (HP:0000059)1.64019116
106Aplasia involving bones of the upper limbs (HP:0009823)1.63612802
107Aplasia of the phalanges of the hand (HP:0009802)1.63612802
108Aplasia involving bones of the extremities (HP:0009825)1.63612802
109Abnormality of molar morphology (HP:0011070)1.63405898
110Abnormality of molar (HP:0011077)1.63405898
111Respiratory difficulties (HP:0002880)1.62671551
112Carious teeth (HP:0000670)1.61763372
113Severe Myopia (HP:0011003)1.61261145
114Congenital, generalized hypertrichosis (HP:0004540)1.61084054
115Abnormality of cells of the erythroid lineage (HP:0012130)1.59158287
116Recurrent corneal erosions (HP:0000495)1.58969770
117White forelock (HP:0002211)1.58245378
118Absent eyebrow (HP:0002223)1.54540863
119Macrocytic anemia (HP:0001972)1.53443470
120Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.52275815
121Hoarse voice (HP:0001609)1.51804210
122Xerostomia (HP:0000217)1.51261784
123Type I diabetes mellitus (HP:0100651)1.50356441
124Abnormality of the renal collecting system (HP:0004742)1.50026821
125Hypodontia (HP:0000668)1.49587323
126Abnormality of the dental pulp (HP:0006479)1.48570824
127Abnormality of the labia majora (HP:0012881)1.46826815
128Ridged nail (HP:0001807)1.45972777
129Abnormality of the fingernails (HP:0001231)1.45349371
130Tetraparesis (HP:0002273)1.42410016
131Papilloma (HP:0012740)1.41967394
132Verrucae (HP:0200043)1.41967394
133Labial hypoplasia (HP:0000066)1.41580311

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R5.27499445
2TGFBR15.21962428
3MST44.41611876
4MAPKAPK34.35256747
5MAP3K23.91865289
6MAP3K32.94405656
7MAP3K92.94404999
8STK102.57813078
9SGK4942.44716042
10SGK2232.44716042
11RPS6KB22.26100940
12MAPK72.16746927
13LRRK21.99197502
14MAP3K11.92023619
15TRPM71.87033273
16PIM21.86420044
17FER1.86166588
18TGFBR21.78474244
19PIK3CG1.73297870
20IRAK11.71827764
21MAPKAPK51.67461732
22GRK71.65916841
23EEF2K1.64968618
24EPHA21.62193687
25FGFR21.58763929
26ERBB31.56340723
27BCR1.55093782
28WNK11.52814638
29MET1.50595702
30MAP2K61.48626484
31AKT31.44091036
32NTRK21.40932770
33GRK51.37969601
34MAP2K21.36813316
35LATS11.36401121
36TESK11.32340519
37SYK1.26883700
38IRAK21.23969837
39DYRK1B1.19369880
40ERN11.15447478
41DMPK1.13284322
42IKBKB1.12216677
43NME21.11471828
44SGK21.10349646
45TTN1.04958001
46MAP2K41.03031647
47STK241.02857626
48FGFR41.01778219
49IRAK40.99835801
50MOS0.95761123
51MAP2K10.93523070
52ADRBK10.92264338
53ITK0.91849542
54TAOK30.89705266
55OBSCN0.88427495
56CDK30.87417219
57DYRK30.86511962
58NLK0.86128030
59ABL20.85911150
60MAP3K120.85171885
61LATS20.84110940
62STK390.84013839
63GRK60.81849707
64SGK30.81072445
65MAP3K110.80785614
66PTK20.77342430
67RPS6KB10.76899796
68LIMK10.73500490
69IKBKE0.71454660
70PTK60.71400463
71PKN10.71009102
72KIT0.70638225
73MAPK150.67665296
74MAP2K30.67449107
75TYRO30.66421096
76PDGFRB0.66086881
77GSK3A0.64977928
78EPHA40.64729746
79PRKD10.64263383
80CDK120.63798400
81BMPR20.62740128
82FRK0.62587060
83TEC0.60867971
84STK380.59337221
85OXSR10.58620374
86STK110.58306157
87CASK0.58274517
88TAF10.57882440
89SGK10.56887403
90EPHB20.56314341
91TAOK10.55298321
92TNIK0.54845958
93MAP3K50.53534154
94BRD40.52946176
95MTOR0.52524538
96BLK0.51721051
97MAP3K60.51603821
98RPS6KA20.51193818
99FGR0.50727349
100MAP3K140.49764999
101CSNK1D0.49621570
102RIPK40.48251454
103SRPK10.47316597
104ROCK10.46581625
105MAPKAPK20.46516698
106EIF2AK20.46075570
107PBK0.45821769
108MAP3K100.45634118
109EPHB10.43415178
110PAK30.43405270
111RIPK10.42919993
112RPS6KA10.42709013
113FGFR10.41706344
114STK30.40360398
115STK38L0.40084132
116CDK60.39261958
117ABL10.39180326
118ROCK20.39015361
119FGFR30.37936984
120CAMKK20.36706948
121PDGFRA0.36118107
122PRKCE0.34342400
123MARK20.34167966
124CDK190.33963940
125MAPK120.33758124
126MATK0.33637241
127MAP3K70.33304529
128EPHA30.32693682
129SRC0.31981553
130IRAK30.31836082
131PRKAA20.31436149
132BMX0.31037207
133ILK0.30736898
134ERBB20.29538376
135MAPK40.28337450
136JAK20.28248209
137MAPK90.25307222
138CHUK0.23783434
139PAK20.18899242
140MAPK80.17068000
141IGF1R0.15267208
142ACVR1B0.15118832
143TXK0.14735285
144FLT30.14049532
145HCK0.13824661

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004606.44528034
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.98623300
3Sphingolipid metabolism_Homo sapiens_hsa006003.74180718
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.50572490
5Linoleic acid metabolism_Homo sapiens_hsa005913.46887800
6Fatty acid elongation_Homo sapiens_hsa000623.10292143
7Ribosome_Homo sapiens_hsa030102.88321892
8Arachidonic acid metabolism_Homo sapiens_hsa005902.85339910
9Ether lipid metabolism_Homo sapiens_hsa005652.39941390
10ABC transporters_Homo sapiens_hsa020102.33202762
11Circadian rhythm_Homo sapiens_hsa047102.27948287
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.27266831
13Histidine metabolism_Homo sapiens_hsa003401.90326420
14Steroid biosynthesis_Homo sapiens_hsa001001.41820679
15VEGF signaling pathway_Homo sapiens_hsa043701.39486909
16Serotonergic synapse_Homo sapiens_hsa047261.39016780
17Choline metabolism in cancer_Homo sapiens_hsa052311.30447933
18GnRH signaling pathway_Homo sapiens_hsa049121.27225125
19Phenylalanine metabolism_Homo sapiens_hsa003601.25695075
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.24889505
21Tight junction_Homo sapiens_hsa045301.21274011
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.19777302
23p53 signaling pathway_Homo sapiens_hsa041151.15839627
24Retinol metabolism_Homo sapiens_hsa008301.14661821
25Chemical carcinogenesis_Homo sapiens_hsa052041.11715743
26Sphingolipid signaling pathway_Homo sapiens_hsa040711.07301652
27Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00806168
28Fat digestion and absorption_Homo sapiens_hsa049751.00259858
29Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94718799
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.94464368
31Collecting duct acid secretion_Homo sapiens_hsa049660.92500437
32Primary bile acid biosynthesis_Homo sapiens_hsa001200.92236937
33Long-term depression_Homo sapiens_hsa047300.92163279
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91873187
35Fatty acid biosynthesis_Homo sapiens_hsa000610.91843226
36ECM-receptor interaction_Homo sapiens_hsa045120.91444835
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90888569
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.90785320
39Glycerophospholipid metabolism_Homo sapiens_hsa005640.89549565
40Other glycan degradation_Homo sapiens_hsa005110.88101319
41Ovarian steroidogenesis_Homo sapiens_hsa049130.88042664
42Vascular smooth muscle contraction_Homo sapiens_hsa042700.85816514
43Axon guidance_Homo sapiens_hsa043600.85041088
44Glutathione metabolism_Homo sapiens_hsa004800.84702818
45Vitamin digestion and absorption_Homo sapiens_hsa049770.83873984
46Fatty acid degradation_Homo sapiens_hsa000710.80289648
47Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79429944
48Fatty acid metabolism_Homo sapiens_hsa012120.78334504
49Phospholipase D signaling pathway_Homo sapiens_hsa040720.78030842
50Adherens junction_Homo sapiens_hsa045200.75493304
51Renin secretion_Homo sapiens_hsa049240.74995502
52Leukocyte transendothelial migration_Homo sapiens_hsa046700.73921923
53Platelet activation_Homo sapiens_hsa046110.73343872
54Dorso-ventral axis formation_Homo sapiens_hsa043200.73049585
55MicroRNAs in cancer_Homo sapiens_hsa052060.71269192
56Pancreatic secretion_Homo sapiens_hsa049720.70651383
57Staphylococcus aureus infection_Homo sapiens_hsa051500.69409593
58Tyrosine metabolism_Homo sapiens_hsa003500.68959659
59Amoebiasis_Homo sapiens_hsa051460.68178352
60Bladder cancer_Homo sapiens_hsa052190.66798623
61Mineral absorption_Homo sapiens_hsa049780.66350949
62Acute myeloid leukemia_Homo sapiens_hsa052210.65562869
63Inositol phosphate metabolism_Homo sapiens_hsa005620.64496003
64Glycerolipid metabolism_Homo sapiens_hsa005610.63942075
65Pertussis_Homo sapiens_hsa051330.63509880
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62649063
67Peroxisome_Homo sapiens_hsa041460.62579350
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.61380180
69Glioma_Homo sapiens_hsa052140.61257800
70Renal cell carcinoma_Homo sapiens_hsa052110.59510309
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.59335948
72Melanogenesis_Homo sapiens_hsa049160.59035902
73Ras signaling pathway_Homo sapiens_hsa040140.58956637
74Proteoglycans in cancer_Homo sapiens_hsa052050.57895238
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56147381
76Sulfur metabolism_Homo sapiens_hsa009200.56064319
77RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.54683379
78PPAR signaling pathway_Homo sapiens_hsa033200.53144412
79Tuberculosis_Homo sapiens_hsa051520.52843380
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.51160531
81Oxidative phosphorylation_Homo sapiens_hsa001900.51156002
82Glutamatergic synapse_Homo sapiens_hsa047240.50391759
83Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50156843
84Thyroid cancer_Homo sapiens_hsa052160.48589992
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48505141
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48424575
87Gastric acid secretion_Homo sapiens_hsa049710.47942866
88Alzheimers disease_Homo sapiens_hsa050100.47047081
89Rap1 signaling pathway_Homo sapiens_hsa040150.46002032
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.44547453
91Hepatitis C_Homo sapiens_hsa051600.44524618
92Hedgehog signaling pathway_Homo sapiens_hsa043400.43496208
93Oxytocin signaling pathway_Homo sapiens_hsa049210.42856219
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.41722218
95Phototransduction_Homo sapiens_hsa047440.38621413
96Vibrio cholerae infection_Homo sapiens_hsa051100.38300194
97FoxO signaling pathway_Homo sapiens_hsa040680.38115395
98Basal cell carcinoma_Homo sapiens_hsa052170.36621649
99Salivary secretion_Homo sapiens_hsa049700.36412018
100Protein digestion and absorption_Homo sapiens_hsa049740.33280766
101Gap junction_Homo sapiens_hsa045400.32245856
102TGF-beta signaling pathway_Homo sapiens_hsa043500.31638813
103Insulin signaling pathway_Homo sapiens_hsa049100.31621055
104Complement and coagulation cascades_Homo sapiens_hsa046100.31551357
105Estrogen signaling pathway_Homo sapiens_hsa049150.31175633
106cAMP signaling pathway_Homo sapiens_hsa040240.31076375
107Nitrogen metabolism_Homo sapiens_hsa009100.30912591
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30884715
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.30549164
110ErbB signaling pathway_Homo sapiens_hsa040120.30491614
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30177810
112Wnt signaling pathway_Homo sapiens_hsa043100.29090071
113HIF-1 signaling pathway_Homo sapiens_hsa040660.28957980
114Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.28765377
115Toxoplasmosis_Homo sapiens_hsa051450.28498067
116Amphetamine addiction_Homo sapiens_hsa050310.28281165
117beta-Alanine metabolism_Homo sapiens_hsa004100.28185048
118Influenza A_Homo sapiens_hsa051640.27902122
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.26314108
120Circadian entrainment_Homo sapiens_hsa047130.25140947
121NOD-like receptor signaling pathway_Homo sapiens_hsa046210.25009767
122Hippo signaling pathway_Homo sapiens_hsa043900.24948419
123Salmonella infection_Homo sapiens_hsa051320.24752937
124Arginine biosynthesis_Homo sapiens_hsa002200.24528298
125MAPK signaling pathway_Homo sapiens_hsa040100.24502691
126Renin-angiotensin system_Homo sapiens_hsa046140.24378948
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.23747152
128Pancreatic cancer_Homo sapiens_hsa052120.23425503
129Pathways in cancer_Homo sapiens_hsa052000.22822363
130Calcium signaling pathway_Homo sapiens_hsa040200.22636669
131Endocytosis_Homo sapiens_hsa041440.22267268
132Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.22064415
133Caffeine metabolism_Homo sapiens_hsa002320.21100805
134Cardiac muscle contraction_Homo sapiens_hsa042600.20265900
135Long-term potentiation_Homo sapiens_hsa047200.18601980

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