LCE3C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinocyte differentiation (GO:0030216)9.62364777
2multicellular organismal water homeostasis (GO:0050891)8.77530514
3hemidesmosome assembly (GO:0031581)7.78509310
4cell wall macromolecule metabolic process (GO:0044036)7.65789744
5cell wall macromolecule catabolic process (GO:0016998)7.65789744
6water homeostasis (GO:0030104)7.25765750
7epidermal cell differentiation (GO:0009913)7.02757321
8negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)6.63358519
9intermediate filament organization (GO:0045109)6.51027610
10skin morphogenesis (GO:0043589)6.26306830
11bundle of His cell to Purkinje myocyte communication (GO:0086069)6.24481879
12epidermis development (GO:0008544)6.19968636
13long-chain fatty acid biosynthetic process (GO:0042759)6.13154794
14ectoderm development (GO:0007398)5.16109865
15regulation of keratinocyte differentiation (GO:0045616)4.88851696
16linoleic acid metabolic process (GO:0043651)4.82592589
17sarcoplasmic reticulum calcium ion transport (GO:0070296)4.68008835
18intermediate filament cytoskeleton organization (GO:0045104)4.55124354
19intermediate filament-based process (GO:0045103)4.44747111
20muscle filament sliding (GO:0030049)4.21000144
21actin-myosin filament sliding (GO:0033275)4.21000144
22regulation of skeletal muscle contraction (GO:0014819)4.03093026
23fatty acid elongation (GO:0030497)3.97826393
24lipoxygenase pathway (GO:0019372)3.95149421
25virion attachment to host cell (GO:0019062)3.84602579
26adhesion of symbiont to host cell (GO:0044650)3.84602579
27regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.74642767
28regulation of skeletal muscle cell differentiation (GO:2001014)3.65720947
29regulation of cardioblast proliferation (GO:0003264)3.58991888
30regulation of secondary heart field cardioblast proliferation (GO:0003266)3.58991888
31muscle organ morphogenesis (GO:0048644)3.57064853
32coronary vasculature morphogenesis (GO:0060977)3.55208947
33skeletal muscle contraction (GO:0003009)3.50316025
34actin-mediated cell contraction (GO:0070252)3.48268430
35lymph vessel development (GO:0001945)3.46748159
36regulation of epidermal cell differentiation (GO:0045604)3.43695669
37skin development (GO:0043588)3.41858014
38fibrinolysis (GO:0042730)3.35693255
39tooth mineralization (GO:0034505)3.35207318
40outer ear morphogenesis (GO:0042473)3.34227518
41glucosamine-containing compound catabolic process (GO:1901072)3.23046493
42adhesion of symbiont to host (GO:0044406)3.18567578
43response to vitamin A (GO:0033189)3.18360139
44ventricular cardiac muscle cell action potential (GO:0086005)3.16965390
45keratinocyte proliferation (GO:0043616)3.11179274
46keratinocyte development (GO:0003334)3.02861284
47* keratinization (GO:0031424)26.9227330
48purine nucleotide salvage (GO:0032261)2.94822932
49regulation of epidermis development (GO:0045682)2.93677493
50regulation of relaxation of muscle (GO:1901077)2.89111880
51skeletal muscle adaptation (GO:0043501)2.86915869
52long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.85169755
53myotube differentiation (GO:0014902)2.83798349
54actin filament-based movement (GO:0030048)2.82800902
55cell-substrate junction assembly (GO:0007044)2.81916473
56plasma membrane repair (GO:0001778)2.80490092
57epithelium development (GO:0060429)2.78571377
58negative regulation of cell fate specification (GO:0009996)2.68131826
59muscle cell fate commitment (GO:0042693)2.64325004
60regulation of heart rate by cardiac conduction (GO:0086091)2.63320354
61surfactant homeostasis (GO:0043129)2.61737573
62positive regulation of monocyte chemotaxis (GO:0090026)2.59789061
63positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.57515721
64fatty-acyl-CoA metabolic process (GO:0035337)2.57380432
65atrioventricular valve morphogenesis (GO:0003181)2.54002230
66positive regulation of myotube differentiation (GO:0010831)2.52816340
67phosphatidylinositol acyl-chain remodeling (GO:0036149)2.52046547
68wound healing (GO:0042060)2.50063132
69negative regulation of toll-like receptor signaling pathway (GO:0034122)2.46556395
70negative regulation of cardiac muscle tissue growth (GO:0055022)2.46029632
71negative regulation of heart growth (GO:0061117)2.46029632
72planar cell polarity pathway involved in neural tube closure (GO:0090179)2.45371486
73primary alcohol catabolic process (GO:0034310)2.45003436
74skeletal muscle fiber development (GO:0048741)2.41114056
75cellular response to retinoic acid (GO:0071300)2.39386065
76innate immune response in mucosa (GO:0002227)2.39044411
77epithelial cell differentiation (GO:0030855)2.38945664
78embryonic viscerocranium morphogenesis (GO:0048703)2.38110643
79epithelial cell-cell adhesion (GO:0090136)2.38084445
80hair follicle morphogenesis (GO:0031069)2.37568146
81cytidine metabolic process (GO:0046087)2.36027520
82cytidine catabolic process (GO:0006216)2.36027520
83cytidine deamination (GO:0009972)2.36027520
84negative regulation of keratinocyte proliferation (GO:0010839)2.35921589
85pyrimidine ribonucleoside catabolic process (GO:0046133)2.32442692
86cell communication involved in cardiac conduction (GO:0086065)2.32009814
87creatine metabolic process (GO:0006600)2.28632902
88striated muscle contraction (GO:0006941)2.28390685
89cytoskeletal anchoring at plasma membrane (GO:0007016)2.28204211
90cochlea morphogenesis (GO:0090103)2.27562021
91regulation of cardioblast differentiation (GO:0051890)2.26431998
92cellular response to epidermal growth factor stimulus (GO:0071364)2.23968831
93regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.23059059
94fatty-acyl-CoA biosynthetic process (GO:0046949)2.21720358
95establishment of skin barrier (GO:0061436)15.2845440
96regulation of water loss via skin (GO:0033561)13.1603118
97peptide cross-linking (GO:0018149)12.0031596
98hair cycle (GO:0042633)11.8799547
99molting cycle (GO:0042303)11.8799547
100desmosome organization (GO:0002934)10.3106916

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.81651149
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.54576073
3P63_26484246_Chip-Seq_KERATINOCYTES_Human3.09129072
4* ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.64093371
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.60207309
6ZNF263_19887448_ChIP-Seq_K562_Human2.53523730
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.38797973
8SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.24486154
9TP63_17297297_ChIP-ChIP_HaCaT_Human14.3371673
10TRIM28_21343339_ChIP-Seq_HEK293_Human1.85171698
11SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.83863494
12SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.83863494
13ESR2_21235772_ChIP-Seq_MCF-7_Human1.83746027
14RARG_19884340_ChIP-ChIP_MEFs_Mouse1.77188712
15SOX9_24532713_ChIP-Seq_HFSC_Mouse1.76451649
16EGR1_19032775_ChIP-ChIP_M12_Human1.76146919
17CTCF_27219007_Chip-Seq_Bcells_Human1.72303706
18* CTCF_20526341_ChIP-Seq_ESCs_Human1.69676128
19* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.66893329
20RACK7_27058665_Chip-Seq_MCF-7_Human1.55094462
21* ERG_20517297_ChIP-Seq_VCAP_Human1.53527813
22* GATA6_21074721_ChIP-Seq_CACO-2_Human1.47486534
23PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.45586050
24ATF3_27146783_Chip-Seq_COLON_Human1.41565339
25TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40070631
26FOXO3_23340844_ChIP-Seq_DLD1_Human1.38823898
27TP63_22573176_ChIP-Seq_HFKS_Human1.38431553
28KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.37479195
29CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.37065029
30* BCOR_27268052_Chip-Seq_Bcells_Human1.31957538
31E2F1_20622854_ChIP-Seq_HELA_Human1.30621974
32GATA3_24758297_ChIP-Seq_MCF-7_Human1.29910401
33CJUN_26792858_Chip-Seq_BT549_Human1.29841722
34TP63_23658742_ChIP-Seq_EP156T_Human1.28932342
35NANOG_20526341_ChIP-Seq_ESCs_Human1.27710006
36SOX2_20726797_ChIP-Seq_SW620_Human1.27691378
37DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26144176
38SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.24897728
39ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.22528785
40RXR_22108803_ChIP-Seq_LS180_Human1.22062357
41BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19479118
42ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.19356734
43BCL6_27268052_Chip-Seq_Bcells_Human1.18942302
44KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18841781
45TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18736242
46P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.18547459
47LXR_22292898_ChIP-Seq_THP-1_Human1.17660419
48HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16116686
49UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14055126
50SA1_27219007_Chip-Seq_ERYTHROID_Human1.11319982
51P68_20966046_ChIP-Seq_HELA_Human1.10658160
52RUNX1_27514584_Chip-Seq_MCF-7_Human1.10147085
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10017783
54CLOCK_20551151_ChIP-Seq_293T_Human1.06210238
55CEBPB_22108803_ChIP-Seq_LS180_Human1.05350592
56SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02278570
57STAT6_21828071_ChIP-Seq_BEAS2B_Human0.99300712
58* YY1_22570637_ChIP-Seq_MALME-3M_Human0.99071727
59KLF5_25053715_ChIP-Seq_YYC3_Human0.98872921
60CSB_26484114_Chip-Seq_FIBROBLAST_Human0.98256717
61NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.96409295
62TAF2_19829295_ChIP-Seq_ESCs_Human0.94999538
63CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.93604701
64ELK3_25401928_ChIP-Seq_HUVEC_Human0.92969703
65TBX20_22328084_ChIP-Seq_HEART_Mouse0.90473294
66TBX20_22080862_ChIP-Seq_HEART_Mouse0.90473294
67RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.89054563
68OCT1_27270436_Chip-Seq_PROSTATE_Human0.88144513
69FOXH1_21741376_ChIP-Seq_ESCs_Human0.87300797
70SPI1_20517297_ChIP-Seq_HL60_Human0.86871722
71AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.86468453
72P53_21459846_ChIP-Seq_SAOS-2_Human0.86428911
73P300_27058665_Chip-Seq_ZR-75-30cells_Human0.85078648
74TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84704976
75JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84143800
76ESR1_20079471_ChIP-ChIP_T-47D_Human0.83831212
77KDM2B_26808549_Chip-Seq_DND41_Human0.83736513
78JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83474767
79* SMC4_20622854_ChIP-Seq_HELA_Human0.83258439
80ERG_21242973_ChIP-ChIP_JURKAT_Human0.80441019
81TP53_20018659_ChIP-ChIP_R1E_Mouse0.80438300
82VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.79318484
83ZNF217_24962896_ChIP-Seq_MCF-7_Human0.79309914
84UBF1/2_26484160_Chip-Seq_HMECs_Human0.79307366
85CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.78396607
86TCF4_18268006_ChIP-ChIP_LS174T_Human0.78389331
87* RAC3_21632823_ChIP-Seq_H3396_Human0.77892001
88SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.77543438
89EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.77360709
90TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.77331768
91BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.77087249
92PPARA_22158963_ChIP-Seq_LIVER_Mouse0.76831891
93JARID2_20075857_ChIP-Seq_MESCs_Mouse0.73822219
94CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.73373571
95BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.72423876
96EZH2_27294783_Chip-Seq_ESCs_Mouse0.72293527
97TP53_16413492_ChIP-PET_HCT116_Human0.72069250
98AR_21572438_ChIP-Seq_LNCaP_Human0.71896469
99GATA6_25053715_ChIP-Seq_YYC3_Human0.71569689
100SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.71526250

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier8.73441584
2MP0005275_abnormal_skin_tensile7.06209166
3MP0000579_abnormal_nail_morphology6.03463151
4MP0005501_abnormal_skin_physiology5.42126872
5MP0000467_abnormal_esophagus_morphology3.70491051
6MP0010234_abnormal_vibrissa_follicle3.51492435
7MP0003705_abnormal_hypodermis_morpholog3.42761503
8MP0001216_abnormal_epidermal_layer3.09682676
9MP0002234_abnormal_pharynx_morphology2.96512296
10MP0010771_integument_phenotype2.92329682
11MP0004947_skin_inflammation2.89900620
12MP0000647_abnormal_sebaceous_gland2.68706466
13MP0000383_abnormal_hair_follicle2.65311166
14MP0000762_abnormal_tongue_morphology2.62958237
15MP0002060_abnormal_skin_morphology2.61501178
16MP0010678_abnormal_skin_adnexa2.39075084
17MP0003453_abnormal_keratinocyte_physiol2.38175044
18MP0004381_abnormal_hair_follicle2.20282068
19MP0003941_abnormal_skin_development2.09533706
20MP0000377_abnormal_hair_follicle2.09454752
21MP0002098_abnormal_vibrissa_morphology2.08712690
22MP0000427_abnormal_hair_cycle2.08554687
23MP0002254_reproductive_system_inflammat2.07033275
24MP0001188_hyperpigmentation2.02312476
25MP0001243_abnormal_dermal_layer1.94653064
26MP0005451_abnormal_body_composition1.81674794
27MP0004185_abnormal_adipocyte_glucose1.78156546
28MP0000751_myopathy1.76520523
29MP0009931_abnormal_skin_appearance1.64120942
30MP0003191_abnormal_cellular_cholesterol1.58853032
31MP0003566_abnormal_cell_adhesion1.58735469
32MP0000749_muscle_degeneration1.56469018
33MP0002095_abnormal_skin_pigmentation1.49390948
34MP0001191_abnormal_skin_condition1.42857822
35MP0000367_abnormal_coat/_hair1.37156003
36MP0003646_muscle_fatigue1.18877252
37MP0005409_darkened_coat_color1.10857463
38MP0000747_muscle_weakness1.10711411
39MP0001851_eye_inflammation0.98451542
40MP0002837_dystrophic_cardiac_calcinosis0.98205125
41MP0000465_gastrointestinal_hemorrhage0.97589389
42MP0003950_abnormal_plasma_membrane0.89495734
43MP0000750_abnormal_muscle_regeneration0.85603928
44MP0000759_abnormal_skeletal_muscle0.85549640
45MP0005023_abnormal_wound_healing0.84736757
46MP0009053_abnormal_anal_canal0.82860810
47MP0002106_abnormal_muscle_physiology0.82471088
48MP0004087_abnormal_muscle_fiber0.81908348
49MP0008438_abnormal_cutaneous_collagen0.81805316
50MP0000733_abnormal_muscle_development0.80280480
51MP0000678_abnormal_parathyroid_gland0.78817515
52MP0001849_ear_inflammation0.78475083
53MP0005666_abnormal_adipose_tissue0.78125536
54MP0004145_abnormal_muscle_electrophysio0.76576970
55MP0001784_abnormal_fluid_regulation0.76159866
56MP0004130_abnormal_muscle_cell0.73882644
57MP0004036_abnormal_muscle_relaxation0.70370868
58MP0001879_abnormal_lymphatic_vessel0.66939481
59MP0005620_abnormal_muscle_contractility0.61550602
60MP0005369_muscle_phenotype0.61492308
61MP0004782_abnormal_surfactant_physiolog0.60776922
62MP0002177_abnormal_outer_ear0.60379893
63MP0003755_abnormal_palate_morphology0.56220199
64MP0005330_cardiomyopathy0.54333615
65MP0010030_abnormal_orbit_morphology0.52706453
66MP0001340_abnormal_eyelid_morphology0.52532481
67MP0001346_abnormal_lacrimal_gland0.51296109
68MP0005375_adipose_tissue_phenotype0.49692276
69MP0002972_abnormal_cardiac_muscle0.45533759
70MP0004084_abnormal_cardiac_muscle0.45313593
71MP0010352_gastrointestinal_tract_polyps0.44394251
72MP0002269_muscular_atrophy0.42002493
73MP0002332_abnormal_exercise_endurance0.40369485
74MP0000470_abnormal_stomach_morphology0.38203312
75MP0002249_abnormal_larynx_morphology0.37880009
76MP0001958_emphysema0.36242476
77MP0000343_altered_response_to0.34840911
78MP0010368_abnormal_lymphatic_system0.34653778
79MP0003252_abnormal_bile_duct0.34223855
80MP0003329_amyloid_beta_deposits0.33186414
81MP0002127_abnormal_cardiovascular_syste0.31579365
82MP0002971_abnormal_brown_adipose0.29012931
83MP0002282_abnormal_trachea_morphology0.28818710
84MP0001186_pigmentation_phenotype0.28582566
85MP0004885_abnormal_endolymph0.28331173
86MP0001177_atelectasis0.27456804
87MP0003075_altered_response_to0.26166619
88MP0004858_abnormal_nervous_system0.25349981
89MP0010630_abnormal_cardiac_muscle0.25324161
90MP0004272_abnormal_basement_membrane0.25067139
91MP0002111_abnormal_tail_morphology0.24476036
92MP0004270_analgesia0.23276794
93MP0005193_abnormal_anterior_eye0.23267134
94MP0008569_lethality_at_weaning0.22876082
95MP0009697_abnormal_copulation0.22349334
96MP0008961_abnormal_basal_metabolism0.22039369
97MP0003385_abnormal_body_wall0.21832516
98MP0000371_diluted_coat_color0.20909651
99MP0005388_respiratory_system_phenotype0.20759795
100MP0002133_abnormal_respiratory_system0.20759795

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of nail color (HP:0100643)9.82055477
2Increased IgE level (HP:0003212)9.66626003
3Oral leukoplakia (HP:0002745)9.51537401
4Palmoplantar hyperkeratosis (HP:0000972)6.68030610
5Conjunctival hamartoma (HP:0100780)6.65298149
6Thick nail (HP:0001805)6.43632332
7Palmar hyperkeratosis (HP:0010765)6.29965947
8Plantar hyperkeratosis (HP:0007556)6.24036000
9Hypotrichosis (HP:0001006)6.00364213
10Onycholysis (HP:0001806)5.64726708
11Woolly hair (HP:0002224)5.10254004
12Erythroderma (HP:0001019)5.06975297
13Right ventricular cardiomyopathy (HP:0011663)4.89334028
14Erythema (HP:0010783)4.58162902
15Congenital ichthyosiform erythroderma (HP:0007431)4.57487523
16Pili torti (HP:0003777)4.51725706
17Alopecia of scalp (HP:0002293)4.41277529
18Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.36884008
19Muscle fiber inclusion bodies (HP:0100299)4.29834411
20Hamartoma of the eye (HP:0010568)4.27947440
21Distal arthrogryposis (HP:0005684)4.21839671
22Follicular hyperkeratosis (HP:0007502)4.18625066
23Nemaline bodies (HP:0003798)4.01949888
24Fragile nails (HP:0001808)3.98600431
25Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.86842460
26Gangrene (HP:0100758)3.84024293
27Abnormal blistering of the skin (HP:0008066)3.82847889
28Type 1 muscle fiber predominance (HP:0003803)3.78978138
29Exercise-induced myalgia (HP:0003738)3.78019176
30Milia (HP:0001056)3.75551378
31Round ear (HP:0100830)3.72973043
32Increased connective tissue (HP:0009025)3.46400798
33Palmoplantar keratoderma (HP:0000982)3.45174606
34Ulnar deviation of the wrist (HP:0003049)3.32966707
35Myopathic facies (HP:0002058)3.30818250
36Nail dystrophy (HP:0008404)3.29258000
37Hyporeflexia of lower limbs (HP:0002600)3.26516887
38Ectropion (HP:0000656)3.05345197
39Corneal erosion (HP:0200020)3.05287752
40Calcaneovalgus deformity (HP:0001848)3.02062927
41Muscle fiber splitting (HP:0003555)2.98965688
42Difficulty running (HP:0009046)2.88631702
43Exercise-induced muscle cramps (HP:0003710)2.88128909
44Absent phalangeal crease (HP:0006109)2.81426249
45Hypergammaglobulinemia (HP:0010702)2.81374120
46Abnormal hair laboratory examination (HP:0003328)2.72838568
47Eczematoid dermatitis (HP:0000976)2.66359088
48Deformed tarsal bones (HP:0008119)2.65544641
49Hypohidrosis (HP:0000966)2.59321296
50Laryngomalacia (HP:0001601)2.50531941
51Pruritus (HP:0000989)2.46267588
52Ventricular tachycardia (HP:0004756)2.39976212
53Distal lower limb muscle weakness (HP:0009053)2.37172057
54Muscle hypertrophy of the lower extremities (HP:0008968)2.35556065
55Verrucae (HP:0200043)2.33569452
56Papilloma (HP:0012740)2.33569452
57Ridged nail (HP:0001807)2.33003130
58Calf muscle hypertrophy (HP:0008981)2.32473507
59Unilateral renal agenesis (HP:0000122)2.30402086
60Abnormal finger flexion creases (HP:0006143)2.29108093
61Abnormality of skeletal muscle fiber size (HP:0012084)2.28508763
62Abnormality of the neuromuscular junction (HP:0003398)2.27188744
63Fatigable weakness (HP:0003473)2.27188744
64Myoglobinuria (HP:0002913)2.24722122
65Neck muscle weakness (HP:0000467)2.24510880
66Increased variability in muscle fiber diameter (HP:0003557)2.24112101
67Advanced eruption of teeth (HP:0006288)2.15216757
68Lip pit (HP:0100267)2.13656236
69Paralysis (HP:0003470)2.10223715
70Frequent falls (HP:0002359)2.07146389
71Rimmed vacuoles (HP:0003805)2.05572997
72Corneal dystrophy (HP:0001131)2.01552884
73Lack of skin elasticity (HP:0100679)1.96649491
74EMG: myopathic abnormalities (HP:0003458)1.95712891
75Hyperhidrosis (HP:0000975)1.95310742
76Sparse eyelashes (HP:0000653)1.93244364
77Distal lower limb amyotrophy (HP:0008944)1.92348062
78Anonychia (HP:0001798)1.89764406
79Atrophic scars (HP:0001075)1.86996716
80Abnormality of the calf musculature (HP:0001430)1.86192378
81Abnormality of the calcaneus (HP:0008364)1.84553665
82Sudden death (HP:0001699)1.84021196
83Congenital malformation of the right heart (HP:0011723)1.82942916
84Double outlet right ventricle (HP:0001719)1.82942916
85Areflexia of lower limbs (HP:0002522)1.82240071
86Ventricular fibrillation (HP:0001663)1.80845690
87Difficulty climbing stairs (HP:0003551)1.78604911
88Achilles tendon contracture (HP:0001771)1.78586031
89Muscle stiffness (HP:0003552)1.74066398
90Curly hair (HP:0002212)1.73294149
91Natal tooth (HP:0000695)1.72067263
92Scapular winging (HP:0003691)1.70132327
93Hamartoma (HP:0010566)1.67006662
94Autoimmune thrombocytopenia (HP:0001973)1.66893080
95Hyperthyroidism (HP:0000836)1.66727615
96Abnormality of the Achilles tendon (HP:0005109)1.65411836
97Malignant hyperthermia (HP:0002047)1.59719706
98Abnormality of the aortic arch (HP:0012303)1.54505886
99Rhabdomyolysis (HP:0003201)1.54302556
100Spinal rigidity (HP:0003306)1.53278717

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN7.20676108
2PIK3CG4.38374212
3OBSCN3.26364315
4FER3.21399474
5MAP3K33.07931020
6TRIB32.96927121
7MAPKAPK32.78810386
8ERN12.65994455
9MST1R2.62075183
10MAP3K112.61379715
11TIE12.54539296
12MAP2K32.45656384
13TAOK12.31962066
14PHKG22.00936452
15PHKG12.00936452
16FGFR12.00567262
17NME11.83372828
18RIPK11.82513582
19NEK11.75305436
20MAP2K61.72137655
21EPHB21.56612323
22MAP3K21.53812442
23EPHB11.39484255
24PDK41.37282747
25PDK31.37282747
26MAP3K91.33026366
27DMPK1.29780401
28MAP2K41.23683745
29EPHA21.22395624
30LATS11.19834811
31MAP3K11.19215401
32PKN21.17815242
33RPS6KA41.17172221
34RPS6KB21.14341848
35MAP3K61.13319274
36MAP3K71.04864868
37TRPM70.97563048
38TGFBR20.96599936
39MET0.94195572
40LRRK20.93498653
41PDK20.89991862
42LATS20.89489024
43FGFR40.86208857
44PTK60.80415896
45EPHA30.76048007
46BLK0.74478053
47MAPK120.73387421
48EEF2K0.73137260
49FGR0.66938328
50BCR0.66478777
51DDR20.63939800
52PDGFRA0.63692789
53KSR20.63113255
54ERBB30.62054587
55PRKD10.61707892
56MAPKAPK20.60235830
57LIMK10.60218065
58MAP2K10.59882468
59TAOK20.56488977
60MAPK110.56433092
61FGFR30.53020879
62BMX0.51904380
63TYK20.46466874
64TESK10.44910544
65CDK60.39675386
66FGFR20.38951714
67ILK0.38252059
68MAP3K50.37469557
69MST40.35208771
70STK240.34982350
71PIK3CA0.34347249
72PINK10.34243882
73PTK20.33093428
74MAP3K120.31583440
75PKN10.31452522
76PAK20.31119199
77NTRK20.28131506
78MAPKAPK50.27246548
79SGK10.26632497
80PRKCH0.25719813
81BCKDK0.25116586
82TBK10.24880816
83RET0.24275544
84ERBB20.23945230
85RPS6KA10.23682145
86CSK0.22876768
87PAK30.22314552
88JAK10.21491362
89ROCK20.21420572
90MAPK40.19989645
91FYN0.19884838
92TYRO30.19243158
93DYRK1B0.18812531
94GSK3A0.18749031
95LMTK20.18074068
96ROCK10.17758569
97MAP3K80.16713768
98PRKACA0.16695627
99CAMK2G0.16089631
100AKT20.15804763

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine metabolism_Homo sapiens_hsa003603.46183183
2Fat digestion and absorption_Homo sapiens_hsa049753.45239316
3Salivary secretion_Homo sapiens_hsa049703.03974618
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.50009940
5Fatty acid elongation_Homo sapiens_hsa000622.44479001
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.38327662
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.19535276
8Linoleic acid metabolism_Homo sapiens_hsa005912.18774593
9Histidine metabolism_Homo sapiens_hsa003402.08033301
10Tyrosine metabolism_Homo sapiens_hsa003501.87056236
11Arachidonic acid metabolism_Homo sapiens_hsa005901.85422547
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.79585096
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.77168042
14GnRH signaling pathway_Homo sapiens_hsa049121.75071034
15Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.69250117
16beta-Alanine metabolism_Homo sapiens_hsa004101.52825540
17VEGF signaling pathway_Homo sapiens_hsa043701.47465363
18Pertussis_Homo sapiens_hsa051331.47290565
19Glycerolipid metabolism_Homo sapiens_hsa005611.45740926
20Phototransduction_Homo sapiens_hsa047441.42203501
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.42082483
22Staphylococcus aureus infection_Homo sapiens_hsa051501.41335292
23Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.32699349
24Renin secretion_Homo sapiens_hsa049241.28399716
25Fatty acid degradation_Homo sapiens_hsa000711.27059719
26Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26407783
27Dilated cardiomyopathy_Homo sapiens_hsa054141.24557151
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.24208519
29Gastric acid secretion_Homo sapiens_hsa049711.17734047
30Vascular smooth muscle contraction_Homo sapiens_hsa042701.16555519
31ECM-receptor interaction_Homo sapiens_hsa045121.14227352
32Tight junction_Homo sapiens_hsa045301.12986094
33Chemical carcinogenesis_Homo sapiens_hsa052041.06260713
34Ether lipid metabolism_Homo sapiens_hsa005651.05645187
35Cardiac muscle contraction_Homo sapiens_hsa042601.05515236
36Arginine biosynthesis_Homo sapiens_hsa002201.01617951
37Glucagon signaling pathway_Homo sapiens_hsa049220.97893773
38Olfactory transduction_Homo sapiens_hsa047400.97777535
39Alzheimers disease_Homo sapiens_hsa050100.97101435
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.96760611
41Oxytocin signaling pathway_Homo sapiens_hsa049210.96297673
42Caffeine metabolism_Homo sapiens_hsa002320.93865498
43Glioma_Homo sapiens_hsa052140.92966433
44PPAR signaling pathway_Homo sapiens_hsa033200.92404442
45Proteoglycans in cancer_Homo sapiens_hsa052050.90400135
46Melanogenesis_Homo sapiens_hsa049160.89921208
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.88950535
48Long-term potentiation_Homo sapiens_hsa047200.87189038
49Insulin signaling pathway_Homo sapiens_hsa049100.86972217
50Insulin resistance_Homo sapiens_hsa049310.86570335
51Carbon metabolism_Homo sapiens_hsa012000.80944581
52Adherens junction_Homo sapiens_hsa045200.80103870
53Amoebiasis_Homo sapiens_hsa051460.80099987
54Nitrogen metabolism_Homo sapiens_hsa009100.78451300
55Focal adhesion_Homo sapiens_hsa045100.76710410
56Estrogen signaling pathway_Homo sapiens_hsa049150.76482510
57Long-term depression_Homo sapiens_hsa047300.76337048
58Steroid biosynthesis_Homo sapiens_hsa001000.74705967
59Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74559653
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.74366045
61Platelet activation_Homo sapiens_hsa046110.70724011
62Fatty acid metabolism_Homo sapiens_hsa012120.68483952
63Calcium signaling pathway_Homo sapiens_hsa040200.66210588
64Starch and sucrose metabolism_Homo sapiens_hsa005000.63900108
65Adipocytokine signaling pathway_Homo sapiens_hsa049200.61695678
66Bladder cancer_Homo sapiens_hsa052190.60596940
67Central carbon metabolism in cancer_Homo sapiens_hsa052300.59184767
68Toxoplasmosis_Homo sapiens_hsa051450.58928626
69Axon guidance_Homo sapiens_hsa043600.55682105
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54284106
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53970301
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53662425
73Propanoate metabolism_Homo sapiens_hsa006400.53552748
74Circadian entrainment_Homo sapiens_hsa047130.52587774
75Biosynthesis of amino acids_Homo sapiens_hsa012300.49954182
76Sphingolipid metabolism_Homo sapiens_hsa006000.48459038
77Basal cell carcinoma_Homo sapiens_hsa052170.47761049
78Rap1 signaling pathway_Homo sapiens_hsa040150.47204180
79Pancreatic secretion_Homo sapiens_hsa049720.47081474
80Tuberculosis_Homo sapiens_hsa051520.46037789
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45937927
82Acute myeloid leukemia_Homo sapiens_hsa052210.45662435
83Ras signaling pathway_Homo sapiens_hsa040140.44553625
84Salmonella infection_Homo sapiens_hsa051320.43925792
85Fatty acid biosynthesis_Homo sapiens_hsa000610.43106806
86Dorso-ventral axis formation_Homo sapiens_hsa043200.42325641
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.41648501
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.41315972
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40930371
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40853295
91Serotonergic synapse_Homo sapiens_hsa047260.38951511
92Hippo signaling pathway_Homo sapiens_hsa043900.36432030
93ABC transporters_Homo sapiens_hsa020100.31504234
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.31410963
95Renal cell carcinoma_Homo sapiens_hsa052110.30701666
96Amphetamine addiction_Homo sapiens_hsa050310.30163286
97Retinol metabolism_Homo sapiens_hsa008300.28896130
98MAPK signaling pathway_Homo sapiens_hsa040100.28735108
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28366826
100Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.28332707

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