LCE1D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peptide cross-linking (GO:0018149)9.70976787
2hemidesmosome assembly (GO:0031581)9.41704774
3keratinocyte differentiation (GO:0030216)9.24100803
4water homeostasis (GO:0030104)8.74421056
5epidermal cell differentiation (GO:0009913)7.00110224
6skin morphogenesis (GO:0043589)6.69565532
7long-chain fatty acid biosynthetic process (GO:0042759)6.57187454
8intermediate filament organization (GO:0045109)6.51197402
9bundle of His cell to Purkinje myocyte communication (GO:0086069)6.35661975
10epidermis development (GO:0008544)6.02638904
11fatty acid elongation (GO:0030497)5.87625470
12glucosamine-containing compound catabolic process (GO:1901072)5.45374310
13linoleic acid metabolic process (GO:0043651)5.09525710
14keratinocyte proliferation (GO:0043616)5.05782304
15keratinocyte development (GO:0003334)4.28997309
16ectoderm development (GO:0007398)4.18594716
17intermediate filament cytoskeleton organization (GO:0045104)4.16157582
18intermediate filament-based process (GO:0045103)4.03173176
19fibrinolysis (GO:0042730)3.90670218
20skin development (GO:0043588)3.88931469
21lipoxygenase pathway (GO:0019372)3.87971270
22regulation of ruffle assembly (GO:1900027)3.78167037
23long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.65652280
24muscle filament sliding (GO:0030049)3.56354579
25actin-myosin filament sliding (GO:0033275)3.56354579
26adhesion of symbiont to host cell (GO:0044650)3.53596679
27virion attachment to host cell (GO:0019062)3.53596679
28regulation of skeletal muscle contraction (GO:0014819)3.44510231
29phosphatidylinositol acyl-chain remodeling (GO:0036149)3.37164527
30negative regulation of cell fate specification (GO:0009996)3.36492132
31atrioventricular valve morphogenesis (GO:0003181)3.29978633
32long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.24981612
33cell-substrate junction assembly (GO:0007044)3.22665846
34fatty-acyl-CoA metabolic process (GO:0035337)3.14488068
35fatty-acyl-CoA biosynthetic process (GO:0046949)3.14297589
36phosphatidylserine acyl-chain remodeling (GO:0036150)3.04306564
37skeletal muscle adaptation (GO:0043501)3.01596551
38adhesion of symbiont to host (GO:0044406)3.01043411
39* keratinization (GO:0031424)22.8883362
40sphingosine metabolic process (GO:0006670)2.99618041
41actin-mediated cell contraction (GO:0070252)2.99283791
42negative regulation of keratinocyte proliferation (GO:0010839)2.97841978
43primary alcohol catabolic process (GO:0034310)2.97385718
44plasma membrane repair (GO:0001778)2.93235290
45regulation of cardioblast differentiation (GO:0051890)2.91806208
46cell wall macromolecule metabolic process (GO:0044036)2.84956286
47cell wall macromolecule catabolic process (GO:0016998)2.84956286
48epithelium development (GO:0060429)2.84448460
49very long-chain fatty acid metabolic process (GO:0000038)2.81777266
50positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.80538307
51sphingoid metabolic process (GO:0046519)2.77672928
52ventricular cardiac muscle cell action potential (GO:0086005)2.73988764
53negative regulation of muscle hypertrophy (GO:0014741)2.73983659
54regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.68437736
55detection of bacterium (GO:0016045)2.67772853
56negative regulation of cell fate commitment (GO:0010454)2.65391297
57diol metabolic process (GO:0034311)2.64160742
58surfactant homeostasis (GO:0043129)2.60093190
59epithelial cell-cell adhesion (GO:0090136)2.57581109
60regulation of keratinocyte differentiation (GO:0045616)2.55987988
61phospholipid scrambling (GO:0017121)2.54672198
62skeletal muscle contraction (GO:0003009)2.51910417
63establishment of tissue polarity (GO:0007164)2.48424748
64establishment of planar polarity (GO:0001736)2.48424748
65tooth mineralization (GO:0034505)2.47303889
66actin filament-based movement (GO:0030048)2.47091098
67eyelid development in camera-type eye (GO:0061029)2.47087493
68planar cell polarity pathway involved in neural tube closure (GO:0090179)2.46946144
69phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.46098078
70thioester biosynthetic process (GO:0035384)2.44894795
71acyl-CoA biosynthetic process (GO:0071616)2.44894795
72myotube differentiation (GO:0014902)2.43513063
73negative regulation of stress fiber assembly (GO:0051497)2.41903509
74phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.40732579
75regulation of hypersensitivity (GO:0002883)2.40469027
76phospholipid efflux (GO:0033700)2.39905108
77retina homeostasis (GO:0001895)2.39514456
78hair follicle morphogenesis (GO:0031069)2.38426188
79cytoskeletal anchoring at plasma membrane (GO:0007016)2.36913628
80negative regulation of axon extension involved in axon guidance (GO:0048843)2.35089870
81ephrin receptor signaling pathway (GO:0048013)2.34666605
82chemical homeostasis within a tissue (GO:0048875)2.32040726
83positive regulation of monocyte chemotaxis (GO:0090026)2.31269430
84sarcoplasmic reticulum calcium ion transport (GO:0070296)2.30295739
85regulation of heart rate by cardiac conduction (GO:0086091)2.30132290
86positive regulation of epidermis development (GO:0045684)2.29897718
87regulation of skeletal muscle cell differentiation (GO:2001014)2.28075223
88molting cycle process (GO:0022404)2.27910476
89hair cycle process (GO:0022405)2.27910476
90gland morphogenesis (GO:0022612)2.25271414
91regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.24705006
92hair follicle development (GO:0001942)2.23982752
93skeletal muscle fiber development (GO:0048741)2.23759749
94cell communication involved in cardiac conduction (GO:0086065)2.21722653
95establishment of skin barrier (GO:0061436)18.4941700
96regulation of water loss via skin (GO:0033561)15.9593721
97desmosome organization (GO:0002934)13.3829578
98hair cycle (GO:0042633)10.9285108
99molting cycle (GO:0042303)10.9285108
100multicellular organismal water homeostasis (GO:0050891)10.4923036

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.85837789
2P63_26484246_Chip-Seq_KERATINOCYTES_Human3.46393920
3ZNF263_19887448_ChIP-Seq_K562_Human2.52200020
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.49648920
5SOX9_24532713_ChIP-Seq_HFSC_Mouse2.31854689
6ESR1_21235772_ChIP-Seq_MCF-7_Human2.08203484
7SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.01765722
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.01411049
9TP63_17297297_ChIP-ChIP_HaCaT_Human13.9407594
10ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.96209861
11FOXO3_23340844_ChIP-Seq_DLD1_Human1.74015390
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.73215110
13SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.71783882
14SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.71783882
15GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.69769774
16CTCF_27219007_Chip-Seq_Bcells_Human1.63819881
17STAT6_21828071_ChIP-Seq_BEAS2B_Human1.57922028
18GATA6_21074721_ChIP-Seq_CACO-2_Human1.51316631
19PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.50254978
20TP63_22573176_ChIP-Seq_HFKS_Human1.47676175
21TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47145163
22TRIM28_21343339_ChIP-Seq_HEK293_Human1.46628424
23TP63_23658742_ChIP-Seq_EP156T_Human1.46205514
24HIF1A_21447827_ChIP-Seq_MCF-7_Human1.45031894
25CTCF_20526341_ChIP-Seq_ESCs_Human1.43471192
26CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.43261766
27RARG_19884340_ChIP-ChIP_MEFs_Mouse1.41758502
28RXR_22108803_ChIP-Seq_LS180_Human1.36949699
29RACK7_27058665_Chip-Seq_MCF-7_Human1.36321859
30DNAJC2_21179169_ChIP-ChIP_NT2_Human1.27210268
31* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.27122833
32UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.25173744
33ERG_20517297_ChIP-Seq_VCAP_Human1.24537974
34RUNX1_27514584_Chip-Seq_MCF-7_Human1.23501421
35KLF5_25053715_ChIP-Seq_YYC3_Human1.21899175
36ATF3_27146783_Chip-Seq_COLON_Human1.20389520
37SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.19668898
38ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19398017
39AR_21572438_ChIP-Seq_LNCaP_Human1.19083641
40GATA3_24758297_ChIP-Seq_MCF-7_Human1.18624754
41KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18511014
42P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.18204921
43CJUN_26792858_Chip-Seq_BT549_Human1.16227072
44BCOR_27268052_Chip-Seq_Bcells_Human1.16044281
45ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.14629952
46VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.13291540
47TP53_20018659_ChIP-ChIP_R1E_Mouse1.11801622
48LXR_22292898_ChIP-Seq_THP-1_Human1.11186908
49EZH2_27294783_Chip-Seq_ESCs_Mouse1.10982257
50CEBPB_22108803_ChIP-Seq_LS180_Human1.07488593
51KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07454675
52JARID2_20075857_ChIP-Seq_MESCs_Mouse1.06450506
53SOX2_20726797_ChIP-Seq_SW620_Human1.06444379
54YY1_22570637_ChIP-Seq_MALME-3M_Human1.06004381
55BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05159630
56BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.04901216
57SA1_27219007_Chip-Seq_ERYTHROID_Human1.03453909
58TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02986285
59E2F1_20622854_ChIP-Seq_HELA_Human1.02133973
60TP53_18474530_ChIP-ChIP_U2OS_Human1.01947633
61EZH2_27304074_Chip-Seq_ESCs_Mouse0.96623905
62EGR1_19032775_ChIP-ChIP_M12_Human0.96220983
63CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.93368631
64AHR_22903824_ChIP-Seq_MCF-7_Human0.92182131
65RNF2_27304074_Chip-Seq_ESCs_Mouse0.91925037
66BCAT_22108803_ChIP-Seq_LS180_Human0.91316411
67UBF1/2_26484160_Chip-Seq_HMECs_Human0.88822376
68ESR1_20079471_ChIP-ChIP_T-47D_Human0.88440358
69SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.87723335
70P68_20966046_ChIP-Seq_HELA_Human0.87233708
71SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.87199417
72VDR_22108803_ChIP-Seq_LS180_Human0.86848918
73BCL6_27268052_Chip-Seq_Bcells_Human0.86449573
74TAF2_19829295_ChIP-Seq_ESCs_Human0.86271368
75NANOG_20526341_ChIP-Seq_ESCs_Human0.86049938
76EZH2_18974828_ChIP-Seq_MESCs_Mouse0.85840083
77RNF2_18974828_ChIP-Seq_MESCs_Mouse0.85840083
78P300_27058665_Chip-Seq_ZR-75-30cells_Human0.85729144
79TCF4_18268006_ChIP-ChIP_LS174T_Human0.85532805
80HNFA_21074721_ChIP-Seq_CACO-2_Human0.84549225
81SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.83379888
82KDM2B_26808549_Chip-Seq_K562_Human0.82805892
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.81408235
84OCT1_27270436_Chip-Seq_PROSTATE_Human0.81148367
85JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80829196
86FOXH1_21741376_ChIP-Seq_ESCs_Human0.80339809
87TP53_16413492_ChIP-PET_HCT116_Human0.77066310
88RBPJ_21746931_ChIP-Seq_IB4_Human0.76779644
89ERG_21242973_ChIP-ChIP_JURKAT_Human0.76764012
90SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.75729442
91CSB_26484114_Chip-Seq_FIBROBLAST_Human0.75329051
92ARNT_22903824_ChIP-Seq_MCF-7_Human0.74867317
93CDX2_19796622_ChIP-Seq_MESCs_Mouse0.74553291
94MTF2_20144788_ChIP-Seq_MESCs_Mouse0.74228463
95ELF1_20517297_ChIP-Seq_JURKAT_Human0.74057308
96* GATA3_21867929_ChIP-Seq_TH1_Mouse0.74034790
97RING1B_27294783_Chip-Seq_ESCs_Mouse0.73760253
98SA1_27219007_Chip-Seq_Bcells_Human0.73727980
99TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.73611533
100GATA4_25053715_ChIP-Seq_YYC3_Human0.71669320

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier8.95839591
2MP0005275_abnormal_skin_tensile7.91261653
3MP0005501_abnormal_skin_physiology5.43677934
4MP0000579_abnormal_nail_morphology4.85287777
5MP0010234_abnormal_vibrissa_follicle3.71116231
6MP0003705_abnormal_hypodermis_morpholog3.52516989
7MP0002060_abnormal_skin_morphology3.51475588
8MP0001216_abnormal_epidermal_layer3.44527079
9MP0002254_reproductive_system_inflammat3.38350115
10MP0004947_skin_inflammation3.26668329
11MP0010771_integument_phenotype3.25996975
12MP0003941_abnormal_skin_development3.17248505
13MP0000647_abnormal_sebaceous_gland3.09052496
14MP0000383_abnormal_hair_follicle2.99932182
15MP0001188_hyperpigmentation2.80923352
16MP0002098_abnormal_vibrissa_morphology2.68089438
17MP0004381_abnormal_hair_follicle2.60398268
18MP0010678_abnormal_skin_adnexa2.55939955
19MP0000427_abnormal_hair_cycle2.40995746
20MP0000467_abnormal_esophagus_morphology2.29643143
21MP0005451_abnormal_body_composition2.22527795
22MP0003453_abnormal_keratinocyte_physiol2.21630908
23MP0000377_abnormal_hair_follicle2.17047102
24MP0001243_abnormal_dermal_layer1.92791407
25MP0009931_abnormal_skin_appearance1.88591598
26MP0000762_abnormal_tongue_morphology1.84410969
27MP0001191_abnormal_skin_condition1.64780155
28MP0004185_abnormal_adipocyte_glucose1.63534295
29MP0002234_abnormal_pharynx_morphology1.51689651
30MP0003566_abnormal_cell_adhesion1.43532065
31MP0000367_abnormal_coat/_hair1.42481820
32MP0003191_abnormal_cellular_cholesterol1.26027739
33MP0001346_abnormal_lacrimal_gland1.21107751
34MP0002095_abnormal_skin_pigmentation1.15941971
35MP0000566_synostosis1.12547455
36MP0001851_eye_inflammation1.10585406
37MP0005409_darkened_coat_color0.83891853
38MP0000751_myopathy0.81293620
39MP0008438_abnormal_cutaneous_collagen0.78997638
40MP0010030_abnormal_orbit_morphology0.78674663
41MP0001340_abnormal_eyelid_morphology0.78035152
42MP0001784_abnormal_fluid_regulation0.74401240
43MP0002177_abnormal_outer_ear0.74202464
44MP0002009_preneoplasia0.73377488
45MP0000749_muscle_degeneration0.70595124
46MP0001849_ear_inflammation0.64881664
47MP0009053_abnormal_anal_canal0.64440470
48MP0000750_abnormal_muscle_regeneration0.63687805
49MP0004782_abnormal_surfactant_physiolog0.62294704
50MP0000465_gastrointestinal_hemorrhage0.59825502
51MP0005023_abnormal_wound_healing0.58211377
52MP0000747_muscle_weakness0.53857594
53MP0005666_abnormal_adipose_tissue0.52579677
54MP0002877_abnormal_melanocyte_morpholog0.51357973
55MP0009379_abnormal_foot_pigmentation0.48651801
56MP0003755_abnormal_palate_morphology0.47785173
57MP0000759_abnormal_skeletal_muscle0.46252987
58MP0003011_delayed_dark_adaptation0.45886995
59MP0000627_abnormal_mammary_gland0.45675313
60MP0002106_abnormal_muscle_physiology0.44908398
61MP0003763_abnormal_thymus_physiology0.44146475
62MP0009672_abnormal_birth_weight0.43538978
63MP0002006_tumorigenesis0.41773231
64MP0002166_altered_tumor_susceptibility0.41457419
65MP0002111_abnormal_tail_morphology0.41163239
66MP0004087_abnormal_muscle_fiber0.38474445
67MP0003385_abnormal_body_wall0.37843060
68MP0003315_abnormal_perineum_morphology0.37530988
69MP0000537_abnormal_urethra_morphology0.37067039
70MP0004019_abnormal_vitamin_homeostasis0.36785863
71MP0008961_abnormal_basal_metabolism0.35875677
72MP0005620_abnormal_muscle_contractility0.34919509
73MP0005369_muscle_phenotype0.33348286
74MP0006054_spinal_hemorrhage0.32511686
75MP0000470_abnormal_stomach_morphology0.31370087
76MP0005375_adipose_tissue_phenotype0.31259581
77MP0004130_abnormal_muscle_cell0.30850581
78MP0010352_gastrointestinal_tract_polyps0.29464264
79MP0004036_abnormal_muscle_relaxation0.26920602
80MP0000733_abnormal_muscle_development0.26425907
81MP0009384_cardiac_valve_regurgitation0.26368177
82MP0002249_abnormal_larynx_morphology0.26365236
83MP0002090_abnormal_vision0.25681203
84MP0002971_abnormal_brown_adipose0.25362488
85MP0000538_abnormal_urinary_bladder0.25174195
86MP0002282_abnormal_trachea_morphology0.24117722
87MP0004145_abnormal_muscle_electrophysio0.23537239
88MP0003329_amyloid_beta_deposits0.21410103
89MP0002896_abnormal_bone_mineralization0.20864427
90MP0001666_abnormal_nutrient_absorption0.20048082
91MP0002108_abnormal_muscle_morphology0.17682291
92MP0003448_altered_tumor_morphology0.17657927
93MP0002837_dystrophic_cardiac_calcinosis0.15940808
94MP0000432_abnormal_head_morphology0.15567706
95MP0009333_abnormal_splenocyte_physiolog0.15402682
96MP0005076_abnormal_cell_differentiation0.13822855
97MP0005330_cardiomyopathy0.13737145
98MP0000613_abnormal_salivary_gland0.13657689
99MP0003950_abnormal_plasma_membrane0.13332032
100MP0001299_abnormal_eye_distance/0.12231973

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)9.57251500
2Conjunctival hamartoma (HP:0100780)8.38278630
3Hypotrichosis (HP:0001006)7.73826003
4Palmoplantar hyperkeratosis (HP:0000972)7.43164534
5Plantar hyperkeratosis (HP:0007556)7.30150512
6Palmar hyperkeratosis (HP:0010765)7.02364251
7Onycholysis (HP:0001806)6.40904242
8Abnormality of nail color (HP:0100643)6.34738772
9Erythema (HP:0010783)6.28161238
10Erythroderma (HP:0001019)6.18456498
11Woolly hair (HP:0002224)5.88201047
12Hamartoma of the eye (HP:0010568)5.40265861
13Right ventricular cardiomyopathy (HP:0011663)5.37610619
14Pili torti (HP:0003777)5.32447650
15Thick nail (HP:0001805)5.20272361
16Congenital ichthyosiform erythroderma (HP:0007431)5.09416853
17Milia (HP:0001056)5.06596468
18Fragile nails (HP:0001808)4.99213337
19Gangrene (HP:0100758)4.38566010
20Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.27904825
21Abnormal blistering of the skin (HP:0008066)4.27674257
22Nail dystrophy (HP:0008404)3.85806680
23Abnormal hair laboratory examination (HP:0003328)3.82888592
24Hyporeflexia of lower limbs (HP:0002600)3.71556052
25Round ear (HP:0100830)3.70582572
26Type 1 muscle fiber predominance (HP:0003803)3.62621466
27Muscle fiber inclusion bodies (HP:0100299)3.53025050
28Alopecia of scalp (HP:0002293)3.51450437
29Palmoplantar keratoderma (HP:0000982)3.49722261
30Corneal erosion (HP:0200020)3.48632140
31Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.44934418
32Nemaline bodies (HP:0003798)3.40170085
33Distal arthrogryposis (HP:0005684)3.32880306
34Ectropion (HP:0000656)3.28336506
35Eczematoid dermatitis (HP:0000976)3.19348507
36Increased connective tissue (HP:0009025)3.15347378
37Oral leukoplakia (HP:0002745)3.13061992
38Hypohidrosis (HP:0000966)3.09922373
39Parakeratosis (HP:0001036)3.07265888
40Distal lower limb muscle weakness (HP:0009053)3.04344747
41Ventricular tachycardia (HP:0004756)3.01281895
42Atrophic scars (HP:0001075)2.98723149
43Hypergammaglobulinemia (HP:0010702)2.87488229
44Ridged nail (HP:0001807)2.85119968
45Exercise-induced myalgia (HP:0003738)2.81437050
46Myopathic facies (HP:0002058)2.80977321
47Curly hair (HP:0002212)2.77902819
48Pruritus (HP:0000989)2.72367123
49Ulnar deviation of the wrist (HP:0003049)2.68388684
50Follicular hyperkeratosis (HP:0007502)2.64282698
51Sparse eyelashes (HP:0000653)2.60847876
52Calcaneovalgus deformity (HP:0001848)2.57996671
53Advanced eruption of teeth (HP:0006288)2.55877235
54Lip pit (HP:0100267)2.51736991
55Areflexia of lower limbs (HP:0002522)2.51139369
56Hamartoma (HP:0010566)2.50448973
57Muscle fiber splitting (HP:0003555)2.43091115
58Natal tooth (HP:0000695)2.33501057
59Fatigable weakness (HP:0003473)2.30861533
60Abnormality of the neuromuscular junction (HP:0003398)2.30861533
61Deformed tarsal bones (HP:0008119)2.26104000
62Absent phalangeal crease (HP:0006109)2.18631820
63Distal lower limb amyotrophy (HP:0008944)2.13036953
64Lack of skin elasticity (HP:0100679)2.09313541
65Melanocytic nevus (HP:0000995)2.03928670
66Exercise-induced muscle cramps (HP:0003710)2.02023396
67Difficulty running (HP:0009046)2.00972264
68Malignant hyperthermia (HP:0002047)2.00495440
69Acanthosis nigricans (HP:0000956)2.00331746
70Fragile skin (HP:0001030)1.99688051
71Abnormality of skeletal muscle fiber size (HP:0012084)1.97793929
72Brittle hair (HP:0002299)1.97516390
73Hyperhidrosis (HP:0000975)1.94845328
74Verrucae (HP:0200043)1.94345362
75Papilloma (HP:0012740)1.94345362
76Increased variability in muscle fiber diameter (HP:0003557)1.92343412
77Sudden death (HP:0001699)1.89114616
78Neck muscle weakness (HP:0000467)1.88066247
79Achilles tendon contracture (HP:0001771)1.85135240
80Blepharitis (HP:0000498)1.82540740
81Neonatal onset (HP:0003623)1.81070164
82Abnormal finger flexion creases (HP:0006143)1.78214451
83Concave nail (HP:0001598)1.78059036
84Skin ulcer (HP:0200042)1.77577992
85Abnormality of the Achilles tendon (HP:0005109)1.70565146
86Ventricular fibrillation (HP:0001663)1.69978290
87Frequent falls (HP:0002359)1.68944999
88Paralysis (HP:0003470)1.68570590
89Abnormality of the axillary hair (HP:0100134)1.62474565
90Abnormality of secondary sexual hair (HP:0009888)1.62474565
91Sparse scalp hair (HP:0002209)1.57752427
92Abnormality of the salivary glands (HP:0010286)1.56898167
93Severe Myopia (HP:0011003)1.55888928
94Lower limb amyotrophy (HP:0007210)1.54806667
95Anonychia (HP:0001798)1.53336645
96Spinal rigidity (HP:0003306)1.53229116
97Dehydration (HP:0001944)1.52813743
98Aplasia cutis congenita (HP:0001057)1.49724922
99Autoimmune hemolytic anemia (HP:0001890)1.47935718
100Abnormality of the calcaneus (HP:0008364)1.46713355

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPKAPK34.92001734
2TTN4.29346466
3PIK3CG3.91683260
4FER3.66473166
5MST1R3.60363901
6OBSCN3.47369190
7MAP3K33.43279363
8FGFR12.57399718
9TAOK12.49509503
10RIPK12.15813821
11EEF2K2.14809898
12ERN12.10105359
13MAP2K62.05729742
14MAP3K112.04189034
15BCR1.99587353
16RPS6KB21.93148075
17MAP3K21.93057143
18MAP2K31.87285803
19EPHB21.78276544
20LATS11.72384576
21NME11.68497097
22PHKG11.64756744
23PHKG21.64756744
24FGFR21.61630731
25NTRK21.59399935
26TRIB31.57786497
27MAP3K71.46781563
28MAPKAPK51.39399882
29TIE11.27309195
30MAP3K11.24053232
31EPHA21.19192623
32TRPM71.15338808
33MAP3K91.08538122
34MET1.06564779
35DYRK1B1.04794107
36MST41.00548754
37CDK61.00059333
38DMPK0.98309971
39LATS20.97656696
40EPHB10.97510476
41TAOK20.97223420
42MAPKAPK20.94136831
43PTK60.92824996
44STK110.89841973
45FGFR40.88456757
46NEK10.86621790
47BLK0.84634300
48SIK10.82507277
49MAP2K40.81888573
50EPHA30.77994112
51LRRK20.70298359
52STK240.67937863
53MAPK120.67486095
54FGFR30.58766267
55MAP2K10.57336260
56PRKD10.53293754
57TYK20.53221974
58TYRO30.52937190
59BMX0.51969407
60KSR20.51786607
61PRKCI0.51109808
62DDR20.48797142
63ERBB30.46988861
64DAPK20.43990125
65PKN10.43367462
66PTK20.42609100
67PIM20.41686271
68HCK0.41423303
69BRD40.40893445
70MAPK110.38180972
71FGR0.36011570
72GSK3A0.35961675
73ILK0.33205696
74PRKAA20.33082605
75MAP3K60.30709208
76ITK0.29907914
77MAPK40.27499939
78RPS6KA10.26571663
79FYN0.25713085
80RPS6KA40.25447545
81TGFBR20.24721113
82MAP3K140.24537915
83PDK30.24467331
84PDK40.24467331
85MAP3K50.23861425
86ROCK20.23822952
87PRKD20.23641452
88PRKACA0.23182155
89ROCK10.22817891
90TGFBR10.20440670
91PAK30.19925715
92CDK40.18864807
93RET0.18616772
94PDGFRA0.18106762
95RIPK40.17472563
96ERBB20.17388348
97MARK20.16842887
98SRC0.16566130
99PKN20.16135243
100SGK10.16061708

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid elongation_Homo sapiens_hsa000623.73768231
2Linoleic acid metabolism_Homo sapiens_hsa005913.40350583
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.38243621
4Arachidonic acid metabolism_Homo sapiens_hsa005902.44000032
5Phenylalanine metabolism_Homo sapiens_hsa003602.29585189
6Cyanoamino acid metabolism_Homo sapiens_hsa004602.20902741
7Staphylococcus aureus infection_Homo sapiens_hsa051502.20861572
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.15378983
9Fat digestion and absorption_Homo sapiens_hsa049752.11881980
10Ether lipid metabolism_Homo sapiens_hsa005651.96193175
11Histidine metabolism_Homo sapiens_hsa003401.80465845
12Sphingolipid metabolism_Homo sapiens_hsa006001.72168271
13Basal cell carcinoma_Homo sapiens_hsa052171.66998177
14GnRH signaling pathway_Homo sapiens_hsa049121.65652794
15VEGF signaling pathway_Homo sapiens_hsa043701.65008771
16Renin secretion_Homo sapiens_hsa049241.44559183
17Phototransduction_Homo sapiens_hsa047441.43130555
18Vascular smooth muscle contraction_Homo sapiens_hsa042701.35892970
19ECM-receptor interaction_Homo sapiens_hsa045121.33042411
20Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.30369735
21Bladder cancer_Homo sapiens_hsa052191.23767303
22Axon guidance_Homo sapiens_hsa043601.23518400
23Hedgehog signaling pathway_Homo sapiens_hsa043401.22404509
24Tight junction_Homo sapiens_hsa045301.18307777
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.17776350
26Fatty acid biosynthesis_Homo sapiens_hsa000611.15446612
27Salivary secretion_Homo sapiens_hsa049701.13149477
28Tyrosine metabolism_Homo sapiens_hsa003501.12974008
29Steroid biosynthesis_Homo sapiens_hsa001001.07694538
30Long-term depression_Homo sapiens_hsa047301.06510441
31Melanogenesis_Homo sapiens_hsa049161.06264453
32Proteoglycans in cancer_Homo sapiens_hsa052051.05210891
33Oxytocin signaling pathway_Homo sapiens_hsa049211.03531329
34Gastric acid secretion_Homo sapiens_hsa049711.01456931
35Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.99001292
36Amoebiasis_Homo sapiens_hsa051460.98489335
37beta-Alanine metabolism_Homo sapiens_hsa004100.97214171
38Pancreatic secretion_Homo sapiens_hsa049720.96807974
39Adherens junction_Homo sapiens_hsa045200.95601648
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90980173
41ABC transporters_Homo sapiens_hsa020100.88727603
42Ras signaling pathway_Homo sapiens_hsa040140.87200883
43PPAR signaling pathway_Homo sapiens_hsa033200.87049440
44Calcium signaling pathway_Homo sapiens_hsa040200.86538885
45Dilated cardiomyopathy_Homo sapiens_hsa054140.86447941
46Hippo signaling pathway_Homo sapiens_hsa043900.86370977
47Platelet activation_Homo sapiens_hsa046110.86294930
48Pertussis_Homo sapiens_hsa051330.85227920
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84321933
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84118639
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82745650
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.81983233
53Glioma_Homo sapiens_hsa052140.76744246
54Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.76228051
55Sphingolipid signaling pathway_Homo sapiens_hsa040710.75494420
56Protein digestion and absorption_Homo sapiens_hsa049740.75022617
57Retinol metabolism_Homo sapiens_hsa008300.74055816
58Long-term potentiation_Homo sapiens_hsa047200.70726260
59Leukocyte transendothelial migration_Homo sapiens_hsa046700.69852120
60Olfactory transduction_Homo sapiens_hsa047400.69608496
61Toxoplasmosis_Homo sapiens_hsa051450.68855928
62Insulin resistance_Homo sapiens_hsa049310.68775582
63Serotonergic synapse_Homo sapiens_hsa047260.68257656
64Glycerophospholipid metabolism_Homo sapiens_hsa005640.67991967
65Acute myeloid leukemia_Homo sapiens_hsa052210.67109236
66Chemical carcinogenesis_Homo sapiens_hsa052040.65668217
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63201721
68Glucagon signaling pathway_Homo sapiens_hsa049220.62813632
69Focal adhesion_Homo sapiens_hsa045100.61466752
70Fatty acid degradation_Homo sapiens_hsa000710.60852047
71Non-small cell lung cancer_Homo sapiens_hsa052230.59279906
72Rap1 signaling pathway_Homo sapiens_hsa040150.58185053
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.57616613
74MicroRNAs in cancer_Homo sapiens_hsa052060.57304266
75Estrogen signaling pathway_Homo sapiens_hsa049150.55705228
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55244138
77Dorso-ventral axis formation_Homo sapiens_hsa043200.55239424
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52555106
79Fatty acid metabolism_Homo sapiens_hsa012120.51603907
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49160862
81Ovarian steroidogenesis_Homo sapiens_hsa049130.49040981
82Collecting duct acid secretion_Homo sapiens_hsa049660.47699300
83Insulin signaling pathway_Homo sapiens_hsa049100.45621893
84Thyroid cancer_Homo sapiens_hsa052160.45204639
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44460905
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44420143
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44054724
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40457769
89Glycerolipid metabolism_Homo sapiens_hsa005610.40227295
90Salmonella infection_Homo sapiens_hsa051320.37470342
91ErbB signaling pathway_Homo sapiens_hsa040120.37299738
92Notch signaling pathway_Homo sapiens_hsa043300.36618185
93Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36400019
94Small cell lung cancer_Homo sapiens_hsa052220.36196547
95p53 signaling pathway_Homo sapiens_hsa041150.35797022
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34972575
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.34726475
98Circadian entrainment_Homo sapiens_hsa047130.33605198
99Wnt signaling pathway_Homo sapiens_hsa043100.33442492
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33390901

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