LBX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peptidyl-glutamic acid carboxylation (GO:0017187)6.66590292
2protein carboxylation (GO:0018214)6.66590292
3positive regulation of triglyceride lipase activity (GO:0061365)5.84325286
4positive regulation of lipoprotein lipase activity (GO:0051006)5.84325286
5mitotic metaphase plate congression (GO:0007080)5.60810450
6L-phenylalanine metabolic process (GO:0006558)5.60521763
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.60521763
8regulation of spindle organization (GO:0090224)5.57341149
9L-phenylalanine catabolic process (GO:0006559)5.29018914
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.29018914
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.28739212
12plasma lipoprotein particle clearance (GO:0034381)5.24329881
13purine nucleobase biosynthetic process (GO:0009113)5.09819785
14intestinal cholesterol absorption (GO:0030299)5.06736735
15negative regulation of fibrinolysis (GO:0051918)5.05287624
16regulation of fibrinolysis (GO:0051917)5.02051059
17metaphase plate congression (GO:0051310)4.95167855
18very-low-density lipoprotein particle assembly (GO:0034379)4.91248159
19regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.85393681
20high-density lipoprotein particle remodeling (GO:0034375)4.69917725
21cholesterol efflux (GO:0033344)4.64750375
22plasma lipoprotein particle assembly (GO:0034377)4.58079305
23plasma lipoprotein particle remodeling (GO:0034369)4.57951260
24protein-lipid complex remodeling (GO:0034368)4.57951260
25macromolecular complex remodeling (GO:0034367)4.57951260
26GDP-mannose metabolic process (GO:0019673)4.50552408
27regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.48727853
28histone H2A monoubiquitination (GO:0035518)4.34904029
29reverse cholesterol transport (GO:0043691)4.33555655
30negative regulation of cholesterol transport (GO:0032375)4.21840711
31negative regulation of sterol transport (GO:0032372)4.21840711
32DNA replication checkpoint (GO:0000076)4.17931664
33vitamin transmembrane transport (GO:0035461)4.15477987
34regulation of mitotic spindle organization (GO:0060236)4.14194120
35plasma lipoprotein particle organization (GO:0071827)4.11255656
36nucleobase biosynthetic process (GO:0046112)4.09249659
37protein localization to chromosome, centromeric region (GO:0071459)4.07635192
38rRNA methylation (GO:0031167)4.05276199
39regulation of cholesterol esterification (GO:0010872)4.03211597
40regulation of centriole replication (GO:0046599)4.02904190
41histone H2A ubiquitination (GO:0033522)4.01301032
42regulation of exit from mitosis (GO:0007096)3.97984851
43low-density lipoprotein particle remodeling (GO:0034374)3.97659877
44protein-lipid complex assembly (GO:0065005)3.97512826
45mitotic chromosome condensation (GO:0007076)3.97046918
46protein localization to kinetochore (GO:0034501)3.96334846
47aromatic amino acid family catabolic process (GO:0009074)3.93755022
48maturation of 5.8S rRNA (GO:0000460)3.92201721
49folic acid metabolic process (GO:0046655)3.91891983
50phospholipid efflux (GO:0033700)3.87141529
51regulation of plasminogen activation (GO:0010755)3.84752933
52negative regulation of fibroblast apoptotic process (GO:2000270)3.83619120
53protein-lipid complex subunit organization (GO:0071825)3.81057192
54oligosaccharide catabolic process (GO:0009313)3.79499838
55positive regulation of chromosome segregation (GO:0051984)3.76410523
56establishment of chromosome localization (GO:0051303)3.74449940
57DNA damage response, signal transduction resulting in transcription (GO:0042772)3.71333454
58DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.68139567
59cellular response to ATP (GO:0071318)3.68048469
60fibrinolysis (GO:0042730)3.67802516
61monoubiquitinated protein deubiquitination (GO:0035520)3.64082376
62regulation of sister chromatid cohesion (GO:0007063)3.62535849
63ribosome assembly (GO:0042255)3.54900332
64rRNA modification (GO:0000154)3.54593453
65blood vessel maturation (GO:0001955)3.51844663
66protein localization to chromosome (GO:0034502)3.51562933
67regulation of transcription from RNA polymerase I promoter (GO:0006356)3.42136429
68regulation of protein activation cascade (GO:2000257)3.39546863
69sulfur amino acid catabolic process (GO:0000098)3.37958624
70regulation of RNA export from nucleus (GO:0046831)3.37794524
71triglyceride homeostasis (GO:0070328)3.36464396
72acylglycerol homeostasis (GO:0055090)3.36464396
73aromatic amino acid family metabolic process (GO:0009072)3.32956524
74DNA damage induced protein phosphorylation (GO:0006975)3.32633526
75intestinal absorption (GO:0050892)3.32625099
76negative regulation of blood coagulation (GO:0030195)3.31197816
77negative regulation of hemostasis (GO:1900047)3.31197816
78sterol transport (GO:0015918)3.30906885
79cholesterol transport (GO:0030301)3.30906885
80regulation of complement activation (GO:0030449)3.30272633
81protein K6-linked ubiquitination (GO:0085020)3.29453937
82positive regulation of fatty acid biosynthetic process (GO:0045723)3.29309482
83tyrosine metabolic process (GO:0006570)3.25408599
84fat-soluble vitamin biosynthetic process (GO:0042362)3.25054876
85ribosome biogenesis (GO:0042254)3.24449230
86coronary vasculature morphogenesis (GO:0060977)3.22919613
87attachment of spindle microtubules to kinetochore (GO:0008608)3.20190008
88negative regulation of coagulation (GO:0050819)3.18967632
89peptidyl-glutamic acid modification (GO:0018200)3.17103697
90regulation of cholesterol metabolic process (GO:0090181)3.16635925
91blood coagulation, intrinsic pathway (GO:0007597)3.14838858
92IMP biosynthetic process (GO:0006188)3.13943632
93regulation of cardioblast differentiation (GO:0051890)3.13111171
94mannose metabolic process (GO:0006013)3.12338154
95lipoprotein metabolic process (GO:0042157)3.11003598
96regulation of triglyceride metabolic process (GO:0090207)3.09071945
97cholesterol homeostasis (GO:0042632)3.07923307
98glyoxylate metabolic process (GO:0046487)3.06625927
99cellular response to growth hormone stimulus (GO:0071378)3.06301861
100proline metabolic process (GO:0006560)3.03543915
101sterol homeostasis (GO:0055092)3.03251558
102DNA deamination (GO:0045006)3.00023942
103negative regulation of macrophage differentiation (GO:0045650)2.99139524
104galactose catabolic process (GO:0019388)2.98881143
105IMP metabolic process (GO:0046040)2.98781627
106complement activation, alternative pathway (GO:0006957)2.97854358
107diacylglycerol metabolic process (GO:0046339)2.97113840
108negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.94338310
109negative regulation of DNA-templated transcription, elongation (GO:0032785)2.94338310
110regulation of cholesterol homeostasis (GO:2000188)2.91701614
111lung-associated mesenchyme development (GO:0060484)2.91340032
112S-adenosylmethionine metabolic process (GO:0046500)2.90232861
113positive regulation of protein import into nucleus, translocation (GO:0033160)2.89431105
114oocyte maturation (GO:0001556)2.89196949
115negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.89037968
116regulation of triglyceride catabolic process (GO:0010896)2.88936424
117positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.88893841
118positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.88893841
119positive regulation of mitotic sister chromatid separation (GO:1901970)2.88893841
120folic acid transport (GO:0015884)2.85886610
121low-density lipoprotein particle clearance (GO:0034383)2.85390471
122urate metabolic process (GO:0046415)2.85245979
123positive regulation of triglyceride metabolic process (GO:0090208)2.85078822
124regulation of chromosome segregation (GO:0051983)2.84630698
125cellular zinc ion homeostasis (GO:0006882)2.84488074
126polyamine biosynthetic process (GO:0006596)2.84205764
127lung lobe morphogenesis (GO:0060463)2.82851692
128UV protection (GO:0009650)2.82714807
129snRNA transcription (GO:0009301)2.79633322
130regulation of centrosome cycle (GO:0046605)2.79103347
131epoxygenase P450 pathway (GO:0019373)2.78944454
132mitotic G2 DNA damage checkpoint (GO:0007095)2.77971661
133drug catabolic process (GO:0042737)2.75485717
134glycosphingolipid catabolic process (GO:0046479)2.75304120
135acute-phase response (GO:0006953)2.74929351
136UDP-N-acetylglucosamine metabolic process (GO:0006047)2.74722204
137tryptophan catabolic process (GO:0006569)2.73520451
138indole-containing compound catabolic process (GO:0042436)2.73520451
139indolalkylamine catabolic process (GO:0046218)2.73520451
140nucleotide-sugar biosynthetic process (GO:0009226)2.72407970
141cofactor catabolic process (GO:0051187)2.71588792
142glycine metabolic process (GO:0006544)2.70902043
143negative regulation of wound healing (GO:0061045)2.70606140
144serine family amino acid catabolic process (GO:0009071)2.69063073
145mitotic G2/M transition checkpoint (GO:0044818)2.68381471
146positive regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032436)2.67460298
147negative regulation of fatty acid biosynthetic process (GO:0045717)2.66630545
148growth hormone receptor signaling pathway (GO:0060396)2.66573456
149chaperone mediated protein folding requiring cofactor (GO:0051085)2.66294226
150phosphate ion homeostasis (GO:0055062)2.64932068
151trivalent inorganic anion homeostasis (GO:0072506)2.64932068
152nucleoside transmembrane transport (GO:1901642)2.64821727
153regulation of female gonad development (GO:2000194)2.63405173
154regulation of hippo signaling (GO:0035330)2.63046839
155negative regulation of digestive system process (GO:0060457)2.62474945
156regulation of nucleobase-containing compound transport (GO:0032239)2.62140520
157negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.61893579
158mitotic nuclear envelope disassembly (GO:0007077)2.61708619
159ventricular cardiac muscle cell development (GO:0055015)2.61197234
160exogenous drug catabolic process (GO:0042738)2.60418658
161arginine metabolic process (GO:0006525)2.59673841
162response to misfolded protein (GO:0051788)2.59273593
163positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.58623640
164blastocyst development (GO:0001824)2.58284801
165heme transport (GO:0015886)2.57770654
166omega-hydroxylase P450 pathway (GO:0097267)2.57432201
167regulation of lipoprotein particle clearance (GO:0010984)2.56903151
168regulation of activation of Janus kinase activity (GO:0010533)2.55920356
169synaptonemal complex assembly (GO:0007130)2.54989497
170negative regulation of alcohol biosynthetic process (GO:1902931)2.54036527
171purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.53445220
1723-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.53445220
173vitamin biosynthetic process (GO:0009110)2.51679167
174purine nucleotide salvage (GO:0032261)2.51073103
175chromosome segregation (GO:0007059)2.49797933
176regulation of fatty acid biosynthetic process (GO:0042304)2.49771999
177peptidyl-threonine dephosphorylation (GO:0035970)2.49167408
178nuclear envelope disassembly (GO:0051081)2.48801770
179membrane disassembly (GO:0030397)2.48801770
180spindle checkpoint (GO:0031577)2.44745395
181keratan sulfate catabolic process (GO:0042340)2.44323575
182amino acid salvage (GO:0043102)2.43523791
183L-methionine salvage (GO:0071267)2.43523791
184L-methionine biosynthetic process (GO:0071265)2.43523791
185microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.41836434
186regulation of histone phosphorylation (GO:0033127)2.41805968
187histone-serine phosphorylation (GO:0035404)2.41454510
188autophagic vacuole assembly (GO:0000045)2.41167394
189histone phosphorylation (GO:0016572)2.40656768
190regulation of histone H3-K27 methylation (GO:0061085)2.38783101
191corticosteroid receptor signaling pathway (GO:0031958)2.38355236
192positive regulation of macroautophagy (GO:0016239)2.37874254
193positive regulation of autophagy (GO:0010508)2.36976069
194meiosis I (GO:0007127)2.36306103
195C21-steroid hormone biosynthetic process (GO:0006700)2.35733568
196inner cell mass cell proliferation (GO:0001833)2.35424084
197lens morphogenesis in camera-type eye (GO:0002089)2.35344268
198response to hydroperoxide (GO:0033194)2.34955338

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.78650947
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.29508483
3E2F7_22180533_ChIP-Seq_HELA_Human4.11257871
4AR_21909140_ChIP-Seq_LNCAP_Human2.91930777
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.90351322
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.89242906
7LXR_22292898_ChIP-Seq_THP-1_Human2.71369946
8TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.54914435
9ZNF263_19887448_ChIP-Seq_K562_Human2.38243382
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.30695234
11P68_20966046_ChIP-Seq_HELA_Human2.28569814
12CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.19123058
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.18114584
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.12225170
15EGR1_23403033_ChIP-Seq_LIVER_Mouse2.11961104
16CLOCK_20551151_ChIP-Seq_293T_Human2.07786892
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.04699968
18IRF8_22096565_ChIP-ChIP_GC-B_Human2.01244600
19BCL6_27268052_Chip-Seq_Bcells_Human1.91800091
20CREB1_15753290_ChIP-ChIP_HEK293T_Human1.91687761
21E2F4_17652178_ChIP-ChIP_JURKAT_Human1.89233233
22E2F1_20622854_ChIP-Seq_HELA_Human1.85592197
23MYC_22102868_ChIP-Seq_BL_Human1.82890501
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.81385344
25NOTCH1_21737748_ChIP-Seq_TLL_Human1.80762426
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.79721507
27ELK3_25401928_ChIP-Seq_HUVEC_Human1.76206920
28MYC_19079543_ChIP-ChIP_MESCs_Mouse1.74997173
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.74808150
30ELF1_20517297_ChIP-Seq_JURKAT_Human1.74129078
31TET1_21451524_ChIP-Seq_MESCs_Mouse1.73563695
32ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.73177061
33NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.69581511
34TP53_22127205_ChIP-Seq_IMR90_Human1.68695592
35* RARB_24833708_ChIP-Seq_LIVER_Mouse1.62070200
36IRF8_21731497_ChIP-ChIP_J774_Mouse1.61745672
37PHF8_20622854_ChIP-Seq_HELA_Human1.60307487
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.59754285
39KLF4_18555785_ChIP-Seq_MESCs_Mouse1.59516196
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.57924012
41NELFA_20434984_ChIP-Seq_ESCs_Mouse1.54730579
42RXR_22158963_ChIP-Seq_LIVER_Mouse1.53747558
43ETS1_20019798_ChIP-Seq_JURKAT_Human1.53308213
44MYC_18358816_ChIP-ChIP_MESCs_Mouse1.49813198
45KAP1_22055183_ChIP-Seq_ESCs_Mouse1.49518454
46STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.48994830
47RXRA_24833708_ChIP-Seq_LIVER_Mouse1.46987413
48MYB_21317192_ChIP-Seq_ERMYB_Mouse1.46601549
49RARA_24833708_ChIP-Seq_LIVER_Mouse1.46324842
50CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.45161877
51SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.44461085
52SMC4_20622854_ChIP-Seq_HELA_Human1.44285340
53SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.43595776
54EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.43411914
55TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43229269
56ATF3_27146783_Chip-Seq_COLON_Human1.42938349
57PPARA_22158963_ChIP-Seq_LIVER_Mouse1.42933270
58JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.42601503
59NANOG_18555785_ChIP-Seq_MESCs_Mouse1.42416781
60SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.40898717
61RARG_19884340_ChIP-ChIP_MEFs_Mouse1.39822177
62STAT3_1855785_ChIP-Seq_MESCs_Mouse1.39616032
63RAC3_21632823_ChIP-Seq_H3396_Human1.39427874
64TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.38805995
65KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.37833706
66MYCN_18555785_ChIP-Seq_MESCs_Mouse1.36996615
67MYC_19030024_ChIP-ChIP_MESCs_Mouse1.36805079
68FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.36395257
69PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.35679019
70CTCF_27219007_Chip-Seq_ERYTHROID_Human1.35512277
71HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.35504203
72STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34840008
73YY1_22570637_ChIP-Seq_MALME-3M_Human1.34335711
74XRN2_22483619_ChIP-Seq_HELA_Human1.34192517
75HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.34148320
76E2F1_21310950_ChIP-Seq_MCF-7_Human1.33478915
77SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.33156298
78* FOXP1_21924763_ChIP-Seq_HESCs_Human1.32887449
79FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.31659076
80SALL4_18804426_ChIP-ChIP_XEN_Mouse1.31328696
81* HNF4A_19822575_ChIP-Seq_HepG2_Human1.29345306
82RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.29012354
83RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.28676973
84TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.28655505
85CTCF_21964334_Chip-Seq_Bcells_Human1.28063199
86* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.27655116
87TP63_17297297_ChIP-ChIP_HaCaT_Human1.26686589
88NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26383949
89SA1_27219007_Chip-Seq_ERYTHROID_Human1.25958439
90P300_27268052_Chip-Seq_Bcells_Human1.24673569
91CTCF_21964334_ChIP-Seq_BJAB-B_Human1.24647258
92DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24626191
93ERA_21632823_ChIP-Seq_H3396_Human1.24351877
94UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.23807509
95MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.22878808
96PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.22840763
97SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22187491
98VDR_21846776_ChIP-Seq_THP-1_Human1.21200711
99KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21043548
100* GABP_19822575_ChIP-Seq_HepG2_Human1.20610119
101SRF_21415370_ChIP-Seq_HL-1_Mouse1.20430830
102NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.19543435
103GATA6_25053715_ChIP-Seq_YYC3_Human1.19072398
104POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19029312
105CTCF_20526341_ChIP-Seq_ESCs_Human1.18413090
106RACK7_27058665_Chip-Seq_MCF-7_Human1.17774534
107RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.17161768
108KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16604771
109SA1_27219007_Chip-Seq_Bcells_Human1.16601825
110E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.16521120
111TFEB_21752829_ChIP-Seq_HELA_Human1.15875087
112CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15183445
113DCP1A_22483619_ChIP-Seq_HELA_Human1.15036133
114GABP_17652178_ChIP-ChIP_JURKAT_Human1.14869078
115CTCF_27219007_Chip-Seq_Bcells_Human1.14305515
116E2F1_18555785_ChIP-Seq_MESCs_Mouse1.12886919
117HIF1A_21447827_ChIP-Seq_MCF-7_Human1.12808585
118TCF7_22412390_ChIP-Seq_EML_Mouse1.12171227
119GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11352870
120FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11337920
121ERG_21242973_ChIP-ChIP_JURKAT_Human1.11127701
122KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10320458
123FOXA2_19822575_ChIP-Seq_HepG2_Human1.10291330
124ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07107015
125KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.06958461
126CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.06883144
127TP63_22573176_ChIP-Seq_HFKS_Human1.06807798
128* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06498087
129SPI1_23547873_ChIP-Seq_NB4_Human1.05414318
130PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05125961
131SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05043158
132MAF_26560356_Chip-Seq_TH1_Human1.04782836
133GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04678120
134VDR_23849224_ChIP-Seq_CD4+_Human1.04326285
135EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04173717
136E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04090967
137SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03277525
138KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03131290
139TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02349819
140LXR_22158963_ChIP-Seq_LIVER_Mouse1.02290269
141PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02230968
142HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01534008
143THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.01419651
144POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.00820755
145CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00398043
146CTCF_26484167_Chip-Seq_Bcells_Mouse0.99949129
147UBF1/2_26484160_Chip-Seq_HMECs_Human0.99688297
148ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99661404
149P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99376618
150CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99259760
151KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.98678166
152NANOG_21062744_ChIP-ChIP_HESCs_Human0.98413344
153CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98318992
154ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98109734
155CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97896035
156CREB1_26743006_Chip-Seq_LNCaP_Human0.97550919
157SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.97194330
158KDM5A_27292631_Chip-Seq_BREAST_Human0.96598439
159NCOR1_26117541_ChIP-Seq_K562_Human0.96254175
160SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96099110
161KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.94969454
162VDR_24763502_ChIP-Seq_THP-1_Human0.94779621
163BRD4_27068464_Chip-Seq_AML-cells_Mouse0.94235797
164MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.92196358
165KDM2B_26808549_Chip-Seq_DND41_Human0.91868443
166BCOR_27268052_Chip-Seq_Bcells_Human0.91776246
167IRF8_27001747_Chip-Seq_BMDM_Mouse0.90245584
168NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.88113586
169MAF_26560356_Chip-Seq_TH2_Human0.87472904

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.04462698
2MP0010368_abnormal_lymphatic_system4.48121446
3MP0003693_abnormal_embryo_hatching3.65487229
4MP0005451_abnormal_body_composition3.54063106
5MP0009840_abnormal_foam_cell3.50376484
6MP0008875_abnormal_xenobiotic_pharmacok3.49322173
7MP0003172_abnormal_lysosome_physiology3.10275291
8MP0008260_abnormal_autophagy3.02810968
9MP0003718_maternal_effect2.67706287
10MP0003806_abnormal_nucleotide_metabolis2.53464631
11MP0001661_extended_life_span2.52713797
12MP0005171_absent_coat_pigmentation2.46710252
13MP0003111_abnormal_nucleus_morphology2.36310218
14MP0009333_abnormal_splenocyte_physiolog2.25463659
15MP0003077_abnormal_cell_cycle2.24590482
16MP0003705_abnormal_hypodermis_morpholog2.15735205
17MP0010307_abnormal_tumor_latency2.15576377
18MP0005332_abnormal_amino_acid2.05649831
19MP0008007_abnormal_cellular_replicative2.04147010
20MP0003724_increased_susceptibility_to2.02851109
21MP0010094_abnormal_chromosome_stability1.99040366
22MP0003123_paternal_imprinting1.98549127
23MP0003136_yellow_coat_color1.96165822
24MP0005174_abnormal_tail_pigmentation1.93610333
25MP0009780_abnormal_chondrocyte_physiolo1.89663088
26MP0005397_hematopoietic_system_phenotyp1.88405841
27MP0001545_abnormal_hematopoietic_system1.88405841
28MP0009278_abnormal_bone_marrow1.86697600
29MP0001879_abnormal_lymphatic_vessel1.86047916
30MP0003828_pulmonary_edema1.85642873
31MP0001666_abnormal_nutrient_absorption1.85158461
32MP0003303_peritoneal_inflammation1.83818735
33MP0004957_abnormal_blastocyst_morpholog1.78163042
34MP0003191_abnormal_cellular_cholesterol1.75275669
35MP0001730_embryonic_growth_arrest1.74388089
36MP0002396_abnormal_hematopoietic_system1.70940672
37MP0001764_abnormal_homeostasis1.63766494
38MP0002876_abnormal_thyroid_physiology1.63691777
39MP0004185_abnormal_adipocyte_glucose1.63451085
40MP0002653_abnormal_ependyma_morphology1.61058541
41MP0004272_abnormal_basement_membrane1.58965813
42MP0003221_abnormal_cardiomyocyte_apopto1.58459839
43MP0005076_abnormal_cell_differentiation1.56986664
44MP0001849_ear_inflammation1.53456637
45MP0002138_abnormal_hepatobiliary_system1.52529488
46MP0005395_other_phenotype1.52002184
47MP0005083_abnormal_biliary_tract1.44114097
48MP0008058_abnormal_DNA_repair1.43747400
49MP0002118_abnormal_lipid_homeostasis1.41462720
50MP0001697_abnormal_embryo_size1.39333503
51MP0005408_hypopigmentation1.39240156
52MP0009643_abnormal_urine_homeostasis1.38941911
53MP0001672_abnormal_embryogenesis/_devel1.38241925
54MP0005380_embryogenesis_phenotype1.38241925
55MP0005365_abnormal_bile_salt1.37472525
56MP0000015_abnormal_ear_pigmentation1.36180428
57MP0003950_abnormal_plasma_membrane1.35873595
58MP0002088_abnormal_embryonic_growth/wei1.32177938
59MP0003984_embryonic_growth_retardation1.31932650
60MP0008057_abnormal_DNA_replication1.31924634
61MP0000465_gastrointestinal_hemorrhage1.31892850
62MP0000350_abnormal_cell_proliferation1.26898039
63MP0005257_abnormal_intraocular_pressure1.24720691
64MP0005584_abnormal_enzyme/coenzyme_acti1.24693637
65MP0005410_abnormal_fertilization1.23769787
66MP0000639_abnormal_adrenal_gland1.22806752
67MP0008877_abnormal_DNA_methylation1.22797800
68MP0003315_abnormal_perineum_morphology1.21880678
69MP0001119_abnormal_female_reproductive1.21257946
70MP0004019_abnormal_vitamin_homeostasis1.21018130
71MP0002089_abnormal_postnatal_growth/wei1.16445748
72MP0004808_abnormal_hematopoietic_stem1.16093543
73MP0001986_abnormal_taste_sensitivity1.15408605
74MP0005409_darkened_coat_color1.15376636
75MP0008995_early_reproductive_senescence1.12381008
76MP0001851_eye_inflammation1.11427720
77MP0003699_abnormal_female_reproductive1.11349084
78MP0002086_abnormal_extraembryonic_tissu1.10953946
79MP0000371_diluted_coat_color1.09723275
80MP0000750_abnormal_muscle_regeneration1.09124306
81MP0000858_altered_metastatic_potential1.04240658
82MP0002080_prenatal_lethality1.03978582
83MP0001915_intracranial_hemorrhage1.03269539
84MP0000538_abnormal_urinary_bladder0.98824763
85MP0000358_abnormal_cell_content/0.98810519
86MP0005058_abnormal_lysosome_morphology0.98547236
87MP0003567_abnormal_fetal_cardiomyocyte0.97826638
88MP0005023_abnormal_wound_healing0.95641863
89MP0010329_abnormal_lipoprotein_level0.95489630
90MP0000609_abnormal_liver_physiology0.94696033
91MP0008469_abnormal_protein_level0.94475028
92MP0005319_abnormal_enzyme/_coenzyme0.93256131
93MP0002019_abnormal_tumor_incidence0.92635505
94MP0008932_abnormal_embryonic_tissue0.92388284
95MP0005670_abnormal_white_adipose0.91862771
96MP0009697_abnormal_copulation0.90465143
97MP0005167_abnormal_blood-brain_barrier0.90401804
98MP0003943_abnormal_hepatobiliary_system0.90353840
99MP0005636_abnormal_mineral_homeostasis0.89695086
100* MP0002085_abnormal_embryonic_tissue0.88647180
101MP0000598_abnormal_liver_morphology0.88435066
102MP0002210_abnormal_sex_determination0.86368447
103MP0000689_abnormal_spleen_morphology0.86264547
104MP0000653_abnormal_sex_gland0.86208850
105MP0005360_urolithiasis0.86112698
106MP0003186_abnormal_redox_activity0.85418648
107MP0003646_muscle_fatigue0.85284376
108MP0009642_abnormal_blood_homeostasis0.84225720
109MP0000767_abnormal_smooth_muscle0.83288937
110MP0003786_premature_aging0.82550073
111MP0003656_abnormal_erythrocyte_physiolo0.82446488
112MP0000343_altered_response_to0.82082902
113MP0003453_abnormal_keratinocyte_physiol0.81766697
114MP0001614_abnormal_blood_vessel0.81007550
115MP0002148_abnormal_hypersensitivity_rea0.80719756
116MP0003252_abnormal_bile_duct0.80673388
117MP0008438_abnormal_cutaneous_collagen0.79815600
118MP0002132_abnormal_respiratory_system0.79393306
119MP0002127_abnormal_cardiovascular_syste0.78861724
120MP0000678_abnormal_parathyroid_gland0.78090409
121MP0002136_abnormal_kidney_physiology0.77823167
122MP0005464_abnormal_platelet_physiology0.77162493
123MP0003448_altered_tumor_morphology0.76976917
124MP0006082_CNS_inflammation0.75954145
125MP0003300_gastrointestinal_ulcer0.75455734
126MP0005666_abnormal_adipose_tissue0.75406636
127MP0009764_decreased_sensitivity_to0.75013057
128MP0004264_abnormal_extraembryonic_tissu0.74810560
129MP0002722_abnormal_immune_system0.74003378
130MP0005084_abnormal_gallbladder_morpholo0.73435553
131MP0002295_abnormal_pulmonary_circulatio0.72551767
132MP0003195_calcinosis0.70911393
133MP0006138_congestive_heart_failure0.69945143
134MP0009384_cardiac_valve_regurgitation0.69898629
135MP0000733_abnormal_muscle_development0.69869639
136MP0002168_other_aberrant_phenotype0.69867203
137MP0002075_abnormal_coat/hair_pigmentati0.69486817
138MP0000490_abnormal_crypts_of0.69117974
139MP0000685_abnormal_immune_system0.68916419
140MP0002128_abnormal_blood_circulation0.68266244
141MP0001756_abnormal_urination0.68045465
142MP0006036_abnormal_mitochondrial_physio0.67626680
143MP0002398_abnormal_bone_marrow0.67548151
144MP0003938_abnormal_ear_development0.67418844
145MP0002160_abnormal_reproductive_system0.67219505
146MP0005085_abnormal_gallbladder_physiolo0.67171556
147MP0005220_abnormal_exocrine_pancreas0.67150257
148MP0000003_abnormal_adipose_tissue0.67030765
149MP0001533_abnormal_skeleton_physiology0.66937943
150MP0005376_homeostasis/metabolism_phenot0.66232285
151MP0009672_abnormal_birth_weight0.65652914
152MP0001944_abnormal_pancreas_morphology0.65484438
153MP0003436_decreased_susceptibility_to0.65359920
154MP0002277_abnormal_respiratory_mucosa0.65033016
155MP0004381_abnormal_hair_follicle0.64429656
156MP0000681_abnormal_thyroid_gland0.64390641
157MP0001845_abnormal_inflammatory_respons0.62653526
158MP0005389_reproductive_system_phenotype0.61527766
159MP0005647_abnormal_sex_gland0.61171920
160MP0004510_myositis0.59939405
161MP0002971_abnormal_brown_adipose0.59625128
162MP0002693_abnormal_pancreas_physiology0.57750247
163MP0005266_abnormal_metabolism0.56933617
164MP0002078_abnormal_glucose_homeostasis0.56619666
165MP0005330_cardiomyopathy0.55741686
166MP0001919_abnormal_reproductive_system0.55446629
167MP0005387_immune_system_phenotype0.55096458
168MP0001790_abnormal_immune_system0.55096458
169MP0002135_abnormal_kidney_morphology0.54588025
170MP0003879_abnormal_hair_cell0.54580743
171MP0002970_abnormal_white_adipose0.52945278
172MP0005501_abnormal_skin_physiology0.52013254

Predicted human phenotypes

RankGene SetZ-score
1Prolonged partial thromboplastin time (HP:0003645)6.08313831
2Joint hemorrhage (HP:0005261)5.26456843
3Abnormality of aromatic amino acid family metabolism (HP:0004338)4.68523591
4Hemorrhage of the eye (HP:0011885)4.33816122
5Poikiloderma (HP:0001029)3.95009593
6Cervical subluxation (HP:0003308)3.94554554
7Vacuolated lymphocytes (HP:0001922)3.90818060
8Hypobetalipoproteinemia (HP:0003563)3.88753835
9Enlarged penis (HP:0000040)3.87794813
10Breast hypoplasia (HP:0003187)3.81390794
11Abnormality of the intrinsic pathway (HP:0010989)3.80320677
12Polycythemia (HP:0001901)3.74382098
13Capillary hemangiomas (HP:0005306)3.55540163
14Systemic lupus erythematosus (HP:0002725)3.54292552
15Glomerulonephritis (HP:0000099)3.49688572
16Birth length less than 3rd percentile (HP:0003561)3.47832088
17Abnormality of the common coagulation pathway (HP:0010990)3.44962687
18Facial hemangioma (HP:0000329)3.28426268
19Thin bony cortex (HP:0002753)3.24656685
20Squamous cell carcinoma (HP:0002860)3.20441670
21Hypercholesterolemia (HP:0003124)3.20344483
22Hyperglycinemia (HP:0002154)3.19648068
23Dysostosis multiplex (HP:0000943)3.13300541
24Ankle contracture (HP:0006466)3.05833773
25Hypophosphatemic rickets (HP:0004912)3.05716418
26Hyperlipoproteinemia (HP:0010980)3.03623355
27Complement deficiency (HP:0004431)3.01995170
28Generalized aminoaciduria (HP:0002909)2.98897673
29Ulnar bowing (HP:0003031)2.97390176
30Abnormality of monocarboxylic acid metabolism (HP:0010996)2.94155542
31Hypolipoproteinemia (HP:0010981)2.93348621
32Deep venous thrombosis (HP:0002625)2.91028025
33Premature rupture of membranes (HP:0001788)2.84903849
34Gout (HP:0001997)2.83687827
35Hyperglycinuria (HP:0003108)2.82526546
36Reduced antithrombin III activity (HP:0001976)2.81477610
37Congenital stationary night blindness (HP:0007642)2.78961176
38Secondary amenorrhea (HP:0000869)2.73793092
39Ulnar deviation of the wrist (HP:0003049)2.70876128
40Azoospermia (HP:0000027)2.69851390
41Impulsivity (HP:0100710)2.69374976
42Male infertility (HP:0003251)2.68682710
43Difficulty climbing stairs (HP:0003551)2.68546067
44Multiple enchondromatosis (HP:0005701)2.67926986
45Purpura (HP:0000979)2.63236467
46Hypoalphalipoproteinemia (HP:0003233)2.59031760
47Pustule (HP:0200039)2.57547064
48Testicular atrophy (HP:0000029)2.56783098
49Abnormality of glycolipid metabolism (HP:0010969)2.53485571
50Abnormality of liposaccharide metabolism (HP:0010968)2.53485571
51Abnormality of glycosphingolipid metabolism (HP:0004343)2.53485571
52Vaginal fistula (HP:0004320)2.52413078
53Breast aplasia (HP:0100783)2.52146977
54Aplasia/Hypoplasia of the breasts (HP:0010311)2.47184753
55Urinary glycosaminoglycan excretion (HP:0003541)2.45627174
56Mucopolysacchariduria (HP:0008155)2.45627174
57Myocardial infarction (HP:0001658)2.43703276
58Spontaneous abortion (HP:0005268)2.41049691
59Nausea (HP:0002018)2.40943487
60Abnormality of polysaccharide metabolism (HP:0011012)2.39878389
61Abnormality of glycosaminoglycan metabolism (HP:0004371)2.39878389
62Abnormality of mucopolysaccharide metabolism (HP:0011020)2.39878389
63Abnormal spermatogenesis (HP:0008669)2.39022374
64J-shaped sella turcica (HP:0002680)2.38389920
65Widely patent fontanelles and sutures (HP:0004492)2.36710050
66Metaphyseal irregularity (HP:0003025)2.34938408
67Attenuation of retinal blood vessels (HP:0007843)2.33551808
68Arterial tortuosity (HP:0005116)2.33180188
69Shallow orbits (HP:0000586)2.32568111
70Peritonitis (HP:0002586)2.32329817
71Conjunctival telangiectasia (HP:0000524)2.31976952
72Ureteral duplication (HP:0000073)2.31822883
73Neoplasm of the adrenal cortex (HP:0100641)2.31134525
74Pelvic girdle muscle weakness (HP:0003749)2.30791559
75Increased serum ferritin (HP:0003281)2.28900329
76Abnormality of DNA repair (HP:0003254)2.28477037
77Vascular calcification (HP:0004934)2.28107906
78Muscle fiber splitting (HP:0003555)2.27111378
79Beaking of vertebral bodies (HP:0004568)2.26868475
80Abnormality of glycine metabolism (HP:0010895)2.24987707
81Abnormality of serine family amino acid metabolism (HP:0010894)2.24987707
82Menorrhagia (HP:0000132)2.24743457
83Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.24461352
84Rickets (HP:0002748)2.23961575
85Aortic valve stenosis (HP:0001650)2.23827292
86Wrist flexion contracture (HP:0001239)2.23749660
87Osteolytic defects of the hand bones (HP:0009699)2.22449343
88Osteolytic defects of the phalanges of the hand (HP:0009771)2.22449343
89Abnormality of complement system (HP:0005339)2.21314193
90Abnormality of the costochondral junction (HP:0000919)2.20819098
91Petechiae (HP:0000967)2.20315280
92Segmental peripheral demyelination/remyelination (HP:0003481)2.19991418
93Patellar aplasia (HP:0006443)2.19923012
94Cerebral hypomyelination (HP:0006808)2.17653287
95Progressive muscle weakness (HP:0003323)2.17439371
96Oligodactyly (HP:0012165)2.16969285
97Progressive neurologic deterioration (HP:0002344)2.16520823
98Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.15000866
99Death in infancy (HP:0001522)2.14065309
100Premature ovarian failure (HP:0008209)2.13410926
101Entropion (HP:0000621)2.11793985
102Aplasia/Hypoplasia of the patella (HP:0006498)2.11781065
103Atrioventricular block (HP:0001678)2.10503964
104Flared iliac wings (HP:0002869)2.09977980
105Abnormality of dental color (HP:0011073)2.09707397
106Fatigue (HP:0012378)2.09055905
107Joint stiffness (HP:0001387)2.08892303
108Rib fusion (HP:0000902)2.08610786
109Delayed epiphyseal ossification (HP:0002663)2.07901215
110Oligodactyly (hands) (HP:0001180)2.07606279
111Overgrowth (HP:0001548)2.05276797
112Vascular tortuosity (HP:0004948)2.04073438
113Abnormal delivery (HP:0001787)2.03953308
114Mitral stenosis (HP:0001718)2.03731134
115Hypertriglyceridemia (HP:0002155)2.03727846
116Cardiovascular calcification (HP:0011915)2.03312437
117Areflexia of lower limbs (HP:0002522)2.01720227
118Mesangial abnormality (HP:0001966)2.00891123
119Increased neuronal autofluorescent lipopigment (HP:0002074)2.00084038
120Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.98911445
121Nephritis (HP:0000123)1.98703869
122Rough bone trabeculation (HP:0100670)1.97140692
123Abnormality of pyrimidine metabolism (HP:0004353)1.95979447
124Pulmonary fibrosis (HP:0002206)1.95890764
125Soft skin (HP:0000977)1.94871358
126Abnormality of macrophages (HP:0004311)1.94465885
127Slender long bone (HP:0003100)1.91900037
128Protrusio acetabuli (HP:0003179)1.91684777
129Cerebral aneurysm (HP:0004944)1.91470001
130Cheilitis (HP:0100825)1.91034300
131Tetraplegia (HP:0002445)1.90555757
132Reduced subcutaneous adipose tissue (HP:0003758)1.89089610
133Ketosis (HP:0001946)1.89012085
134Gonadal dysgenesis (HP:0000133)1.88227744
135Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.86872769
136Short 1st metacarpal (HP:0010034)1.86872769
137Rectovaginal fistula (HP:0000143)1.86505648
138Rectal fistula (HP:0100590)1.86505648
139Arterial thrombosis (HP:0004420)1.86270186
140Short nail (HP:0001799)1.85690262
141Nonimmune hydrops fetalis (HP:0001790)1.84822519
142Severe visual impairment (HP:0001141)1.83732355
143Enlarged epiphyses (HP:0010580)1.83681703
144Abnormal trabecular bone morphology (HP:0100671)1.83503143
145Cutaneous melanoma (HP:0012056)1.83092886
146Asymmetry of the thorax (HP:0001555)1.83010996
147Increased cerebral lipofuscin (HP:0011813)1.82721201
148Dicarboxylic aciduria (HP:0003215)1.82362079
149Abnormality of dicarboxylic acid metabolism (HP:0010995)1.82362079
150Prolonged neonatal jaundice (HP:0006579)1.81933629
151Bundle branch block (HP:0011710)1.81605997
152Abnormality of glutamine family amino acid metabolism (HP:0010902)1.81422846
153Protuberant abdomen (HP:0001538)1.81353157
154Abnormality of the vasculature of the conjunctiva (HP:0008054)1.79270683
155Flat occiput (HP:0005469)1.78768028
156Abnormality of the hip-girdle musculature (HP:0001445)1.78567175
157Abnormality of the musculature of the pelvis (HP:0001469)1.78567175
158Abnormality of fatty-acid metabolism (HP:0004359)1.77304945
159Abnormality of the umbilical cord (HP:0010881)1.77274671
160Congenital, generalized hypertrichosis (HP:0004540)1.77235066
161Severe short stature (HP:0003510)1.77133082
162Hepatocellular carcinoma (HP:0001402)1.76711977
163Ovoid vertebral bodies (HP:0003300)1.75683206
164Microretrognathia (HP:0000308)1.75555832
165Xanthomatosis (HP:0000991)1.75040147
166Conjugated hyperbilirubinemia (HP:0002908)1.74845722
167Abnormality of iron homeostasis (HP:0011031)1.74227753
168Type I transferrin isoform profile (HP:0003642)1.73970729
169Hydroxyprolinuria (HP:0003080)1.73788708
170Abnormality of proline metabolism (HP:0010907)1.73788708
171Abnormal pupillary function (HP:0007686)1.73217406
172Intestinal fistula (HP:0100819)1.72816496
173Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.72500143
174Shoulder girdle muscle weakness (HP:0003547)1.71604171
175Mutism (HP:0002300)1.71158150
176Spontaneous hematomas (HP:0007420)1.70837525
177Abnormality of the Achilles tendon (HP:0005109)1.68146118
178Hypophosphatemia (HP:0002148)1.67085594
179Hepatic necrosis (HP:0002605)1.66962200
180Hypoalbuminemia (HP:0003073)1.65650768
181Abnormal albumin level (HP:0012116)1.65650768

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CCNB15.23876455
2IRAK34.66694897
3WEE14.00009560
4LATS23.51390311
5BRSK23.50807659
6WNK43.47829566
7LATS13.05373126
8NEK22.91649507
9ICK2.79991387
10EPHA22.63818110
11MAP3K32.45597903
12PKN22.43093604
13TRIB32.41578758
14BUB12.31857776
15MST1R2.14503922
16ACVR1B2.08326749
17KDR2.04496733
18STK31.99180433
19SIK11.97899308
20PIM21.86085560
21TIE11.83945348
22ADRBK21.76807268
23NME21.76186296
24MAP2K31.75257001
25SMG11.72400317
26MAPKAPK31.71340466
27DYRK31.67387932
28BRSK11.55724881
29TGFBR21.55259989
30MKNK21.54404621
31PINK11.53650247
32TYK21.49588630
33STK38L1.47388388
34MAP4K11.45395914
35CDK41.44716682
36IRAK21.42096726
37MAPK151.38806797
38TAOK31.36415263
39MAP3K61.31929091
40RPS6KA41.29833124
41BLK1.27451056
42NLK1.27285556
43PLK41.24803903
44KSR21.23470315
45PDK21.18869595
46DDR21.17748111
47EEF2K1.17272376
48PLK11.17267021
49TTK1.14286837
50PRKD21.12957268
51ARAF1.10874125
52FRK1.10200418
53PDPK11.08450784
54PRKG21.07325222
55STK161.06773248
56MOS1.04938416
57STK101.04590803
58CSNK1G11.03083444
59MUSK1.00204619
60TAOK20.99042482
61LMTK20.97364728
62PRKD30.96302628
63SIK20.93987622
64CDK120.93880740
65VRK20.93743894
66HIPK20.93487466
67NEK90.93296076
68CAMK1D0.92700709
69ZAP700.91972147
70CDK80.91877758
71PTK60.90792596
72MAP3K80.89871417
73EPHB10.89245372
74MAP3K110.89191388
75CHEK20.89093571
76BMX0.88482103
77CDC42BPA0.87772310
78CDK60.86920483
79RET0.85200547
80ERN10.83999789
81TLK10.83589926
82CDK70.82927502
83GRK10.82640123
84GRK60.81431444
85MET0.80808667
86MAP2K20.80120372
87AURKB0.77424601
88DAPK20.74198723
89MAP4K20.73368070
90MKNK10.69773652
91RIPK10.68990136
92MELK0.68833049
93DYRK20.67122437
94BCKDK0.66498796
95JAK20.66350038
96MST40.65381779
97ABL20.65144773
98TBK10.65031199
99JAK30.64596020
100NME10.64558652
101ERBB20.64554355
102NEK10.63490457
103PTK2B0.61682110
104INSRR0.61279638
105FGFR30.59541883
106AURKA0.59282978
107MAP2K60.58794892
108TAOK10.58706176
109RAF10.57435589
110PRKCI0.56772659
111PAK20.56277656
112FLT30.56146494
113MAP2K40.56081375
114FGFR40.54858192
115MARK30.53152245
116CDK90.52249357
117BRAF0.51635779
118MATK0.51406389
119BMPR1B0.51130843
120IKBKB0.50781503
121SGK30.49604251
122AKT30.49388066
123CHUK0.48897753
124CAMKK20.48718317
125GRK70.46924619
126PAK10.45214841
127CDC70.43629805
128AKT20.43439749
129TGFBR10.43397152
130TSSK60.42784759
131PDK10.39442879
132MAPK40.38849043
133MTOR0.38194275
134PLK30.37918188
135GSK3A0.37380685
136DYRK1A0.35456893
137TESK20.35073848
138ALK0.35033973
139ERBB40.34688389
140ZAK0.34427811
141MAPKAPK20.34293541
142SGK20.33805508
143IRAK10.33695336
144MAPK110.33351431
145IRAK40.32789896
146ABL10.32424487
147TTN0.31654876
148PTK20.31318825
149PAK40.30499559
150TNK20.30485258
151ILK0.30124176
152PIM10.29971342
153RPS6KB20.29826087
154TYRO30.29587297
155STK380.29421759
156MAP3K10.29151012
157MAP3K130.28530939

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007506.11816587
2Glycosaminoglycan degradation_Homo sapiens_hsa005312.96771120
3RNA polymerase_Homo sapiens_hsa030202.90134210
4Cell cycle_Homo sapiens_hsa041102.84220209
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.71959404
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.61978951
7Other glycan degradation_Homo sapiens_hsa005112.44394923
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.41013869
9Staphylococcus aureus infection_Homo sapiens_hsa051502.17220880
10Folate biosynthesis_Homo sapiens_hsa007902.13270923
11RNA transport_Homo sapiens_hsa030132.11305973
12Fructose and mannose metabolism_Homo sapiens_hsa000512.05148037
13Sulfur metabolism_Homo sapiens_hsa009201.97290776
14Chemical carcinogenesis_Homo sapiens_hsa052041.93382645
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.83834223
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.83008379
17Fat digestion and absorption_Homo sapiens_hsa049751.78873041
18Complement and coagulation cascades_Homo sapiens_hsa046101.72239292
19ABC transporters_Homo sapiens_hsa020101.69848904
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.69710359
21Fatty acid degradation_Homo sapiens_hsa000711.67177543
22p53 signaling pathway_Homo sapiens_hsa041151.65638983
23Tryptophan metabolism_Homo sapiens_hsa003801.63983314
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.62949242
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.58353528
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.57985249
27One carbon pool by folate_Homo sapiens_hsa006701.53321244
28Circadian rhythm_Homo sapiens_hsa047101.52578084
29Caffeine metabolism_Homo sapiens_hsa002321.48870359
30Pentose and glucuronate interconversions_Homo sapiens_hsa000401.47696976
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.44714600
32Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.44539524
33Tyrosine metabolism_Homo sapiens_hsa003501.43736296
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.41672933
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.40985993
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.40952225
37Phenylalanine metabolism_Homo sapiens_hsa003601.39834388
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.37661175
39Retinol metabolism_Homo sapiens_hsa008301.36864681
40Vitamin digestion and absorption_Homo sapiens_hsa049771.34523210
41Regulation of autophagy_Homo sapiens_hsa041401.32160971
42Pentose phosphate pathway_Homo sapiens_hsa000301.28593090
43Lysosome_Homo sapiens_hsa041421.25876721
44Basal transcription factors_Homo sapiens_hsa030221.24110965
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.21926528
46Oocyte meiosis_Homo sapiens_hsa041141.20051641
47Ovarian steroidogenesis_Homo sapiens_hsa049131.17934722
48DNA replication_Homo sapiens_hsa030301.13716614
49Glutathione metabolism_Homo sapiens_hsa004801.11057891
50Glycerophospholipid metabolism_Homo sapiens_hsa005641.08557332
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07962409
52Biosynthesis of amino acids_Homo sapiens_hsa012301.06197994
53Thyroid cancer_Homo sapiens_hsa052161.05652971
54Butanoate metabolism_Homo sapiens_hsa006501.04485253
55Peroxisome_Homo sapiens_hsa041461.03951580
56Starch and sucrose metabolism_Homo sapiens_hsa005001.01896380
57Sulfur relay system_Homo sapiens_hsa041221.00780947
58Pyrimidine metabolism_Homo sapiens_hsa002401.00698120
59Herpes simplex infection_Homo sapiens_hsa051680.99975403
60RNA degradation_Homo sapiens_hsa030180.99256754
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.98788062
62Pancreatic cancer_Homo sapiens_hsa052120.98207686
63Fatty acid elongation_Homo sapiens_hsa000620.97009592
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.95831228
65Lysine degradation_Homo sapiens_hsa003100.95568039
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.95512762
67Fatty acid metabolism_Homo sapiens_hsa012120.92639392
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90252270
69Small cell lung cancer_Homo sapiens_hsa052220.89612320
70Prolactin signaling pathway_Homo sapiens_hsa049170.89520325
71N-Glycan biosynthesis_Homo sapiens_hsa005100.89293305
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.86852620
73Steroid biosynthesis_Homo sapiens_hsa001000.86615577
74MicroRNAs in cancer_Homo sapiens_hsa052060.83919611
75Arginine biosynthesis_Homo sapiens_hsa002200.82791240
76mTOR signaling pathway_Homo sapiens_hsa041500.82270072
77Insulin resistance_Homo sapiens_hsa049310.79862815
78Bile secretion_Homo sapiens_hsa049760.78978041
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76735499
80Histidine metabolism_Homo sapiens_hsa003400.76238115
81Spliceosome_Homo sapiens_hsa030400.75938473
82Leishmaniasis_Homo sapiens_hsa051400.75389603
83Epstein-Barr virus infection_Homo sapiens_hsa051690.75351841
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74971495
85FoxO signaling pathway_Homo sapiens_hsa040680.74740083
86Base excision repair_Homo sapiens_hsa034100.73202175
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72700126
88Mineral absorption_Homo sapiens_hsa049780.71612159
89Fanconi anemia pathway_Homo sapiens_hsa034600.70951538
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70347687
91Purine metabolism_Homo sapiens_hsa002300.69808615
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68664236
93TGF-beta signaling pathway_Homo sapiens_hsa043500.68636671
94Glycerolipid metabolism_Homo sapiens_hsa005610.67853205
95HTLV-I infection_Homo sapiens_hsa051660.66981845
96Arginine and proline metabolism_Homo sapiens_hsa003300.66980254
97Chronic myeloid leukemia_Homo sapiens_hsa052200.66774279
98Shigellosis_Homo sapiens_hsa051310.66495016
99Hepatitis B_Homo sapiens_hsa051610.66276340
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64947455
101Metabolic pathways_Homo sapiens_hsa011000.64552142
102Osteoclast differentiation_Homo sapiens_hsa043800.64114300
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63456839
104Apoptosis_Homo sapiens_hsa042100.62985913
105Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62434799
106Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62420257
107Renal cell carcinoma_Homo sapiens_hsa052110.62205385
108Homologous recombination_Homo sapiens_hsa034400.60647692
109Non-small cell lung cancer_Homo sapiens_hsa052230.60190266
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.60117844
111Bladder cancer_Homo sapiens_hsa052190.59354008
112Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59293331
113Toxoplasmosis_Homo sapiens_hsa051450.58729260
114Nucleotide excision repair_Homo sapiens_hsa034200.54638443
115Prostate cancer_Homo sapiens_hsa052150.54371406
116Jak-STAT signaling pathway_Homo sapiens_hsa046300.54064975
117Prion diseases_Homo sapiens_hsa050200.52870645
118Pertussis_Homo sapiens_hsa051330.52468592
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51893000
120Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50917104
121Selenocompound metabolism_Homo sapiens_hsa004500.50644873
122Hippo signaling pathway_Homo sapiens_hsa043900.50460047
123Pyruvate metabolism_Homo sapiens_hsa006200.49860563
124Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49335932
125Galactose metabolism_Homo sapiens_hsa000520.48636730
126Antigen processing and presentation_Homo sapiens_hsa046120.48266382
127Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48125359
128Adherens junction_Homo sapiens_hsa045200.47430588
129PPAR signaling pathway_Homo sapiens_hsa033200.45502382
130Measles_Homo sapiens_hsa051620.44594126
131Malaria_Homo sapiens_hsa051440.44061498
132Choline metabolism in cancer_Homo sapiens_hsa052310.43785539
133HIF-1 signaling pathway_Homo sapiens_hsa040660.42088187
134AMPK signaling pathway_Homo sapiens_hsa041520.39827679
135Influenza A_Homo sapiens_hsa051640.39437726
136Colorectal cancer_Homo sapiens_hsa052100.39320420
137Hedgehog signaling pathway_Homo sapiens_hsa043400.39243743
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39174750
139Sphingolipid metabolism_Homo sapiens_hsa006000.38849603
140VEGF signaling pathway_Homo sapiens_hsa043700.38576375
141Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.38299568
142Primary bile acid biosynthesis_Homo sapiens_hsa001200.38041803
143Legionellosis_Homo sapiens_hsa051340.37817927
144mRNA surveillance pathway_Homo sapiens_hsa030150.37750414
145TNF signaling pathway_Homo sapiens_hsa046680.37383071
146Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37130396
147Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36636544
148Arachidonic acid metabolism_Homo sapiens_hsa005900.35606468
149Systemic lupus erythematosus_Homo sapiens_hsa053220.32918378
150Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.32890730
151Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31577253
152SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31242115
153Carbon metabolism_Homo sapiens_hsa012000.29849859
154Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29842209
155NF-kappa B signaling pathway_Homo sapiens_hsa040640.28765410
156beta-Alanine metabolism_Homo sapiens_hsa004100.28065724
157Insulin signaling pathway_Homo sapiens_hsa049100.23257189
158Fatty acid biosynthesis_Homo sapiens_hsa000610.22841573
159RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.20139662

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