LBR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)4.83270311
2DNA strand elongation involved in DNA replication (GO:0006271)4.78860567
3telomere maintenance via semi-conservative replication (GO:0032201)4.70691747
4DNA unwinding involved in DNA replication (GO:0006268)4.67901614
5DNA strand elongation (GO:0022616)4.58647354
6DNA replication initiation (GO:0006270)4.34861058
7CENP-A containing nucleosome assembly (GO:0034080)4.31586010
8telomere maintenance via recombination (GO:0000722)4.31460827
9mitotic recombination (GO:0006312)4.29916966
10mitotic chromosome condensation (GO:0007076)4.29221626
11protein localization to chromosome, centromeric region (GO:0071459)4.21546399
12chromatin remodeling at centromere (GO:0031055)4.19788504
13kinetochore organization (GO:0051383)4.18520046
14DNA replication checkpoint (GO:0000076)4.13239171
15attachment of spindle microtubules to kinetochore (GO:0008608)4.06731895
16mitotic metaphase plate congression (GO:0007080)3.98062086
17mitotic sister chromatid segregation (GO:0000070)3.93286124
18ribosomal small subunit assembly (GO:0000028)3.90074580
19DNA replication-independent nucleosome organization (GO:0034724)3.88260876
20DNA replication-independent nucleosome assembly (GO:0006336)3.88260876
21sister chromatid segregation (GO:0000819)3.83196125
22regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.76675494
23establishment of chromosome localization (GO:0051303)3.72207491
24nucleotide-excision repair, DNA gap filling (GO:0006297)3.71523386
25nuclear pore organization (GO:0006999)3.70465399
26telomere maintenance via telomere lengthening (GO:0010833)3.70194790
27metaphase plate congression (GO:0051310)3.66580820
28nuclear pore complex assembly (GO:0051292)3.66306179
29meiotic chromosome segregation (GO:0045132)3.65994268
30IMP biosynthetic process (GO:0006188)3.64358921
31mitotic nuclear envelope disassembly (GO:0007077)3.61570588
32DNA topological change (GO:0006265)3.59625749
33DNA replication-dependent nucleosome assembly (GO:0006335)3.50828210
34DNA replication-dependent nucleosome organization (GO:0034723)3.50828210
35positive regulation of gamma-delta T cell activation (GO:0046645)3.48619786
36histone exchange (GO:0043486)3.42896304
37kinetochore assembly (GO:0051382)3.41840431
38nucleobase biosynthetic process (GO:0046112)3.37760655
39regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.36537726
40regulation of spindle organization (GO:0090224)3.36006692
41nuclear envelope disassembly (GO:0051081)3.29909096
42membrane disassembly (GO:0030397)3.29909096
43IMP metabolic process (GO:0046040)3.28060844
44mitotic G2/M transition checkpoint (GO:0044818)3.26302909
45telomere maintenance (GO:0000723)3.23263800
46telomere organization (GO:0032200)3.22809236
47DNA ligation (GO:0006266)3.21459983
48DNA duplex unwinding (GO:0032508)3.16770677
49negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.16300324
50DNA geometric change (GO:0032392)3.15636441
51mitotic sister chromatid cohesion (GO:0007064)3.15591611
52regulation of sister chromatid cohesion (GO:0007063)3.11762439
53double-strand break repair via nonhomologous end joining (GO:0006303)3.11577551
54non-recombinational repair (GO:0000726)3.11577551
55positive regulation of chromosome segregation (GO:0051984)3.10848262
56regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.09396562
57somatic hypermutation of immunoglobulin genes (GO:0016446)3.08135783
58somatic diversification of immune receptors via somatic mutation (GO:0002566)3.08135783
59protein localization to chromosome (GO:0034502)3.07311639
60purine nucleobase biosynthetic process (GO:0009113)3.06058396
61chromatin assembly or disassembly (GO:0006333)3.03766612
62chromosome segregation (GO:0007059)3.03739846
63pore complex assembly (GO:0046931)3.01969357
64spindle checkpoint (GO:0031577)3.00822489
65mismatch repair (GO:0006298)3.00051999
66negative regulation of mRNA processing (GO:0050686)2.98269475
67nuclear envelope organization (GO:0006998)2.97821226
68mitotic G2 DNA damage checkpoint (GO:0007095)2.97519625
69regulation of RNA export from nucleus (GO:0046831)2.97086360
70negative regulation of phagocytosis (GO:0050765)2.97034156
71negative regulation of mRNA metabolic process (GO:1903312)2.94574995
72DNA conformation change (GO:0071103)2.93658502
73positive regulation of B cell differentiation (GO:0045579)2.93330136
74microtubule depolymerization (GO:0007019)2.92559326
75ATP-dependent chromatin remodeling (GO:0043044)2.92171501
76regulation of double-strand break repair via homologous recombination (GO:0010569)2.89382485
77negative regulation of RNA splicing (GO:0033119)2.89142907
78regulation of nuclear cell cycle DNA replication (GO:0033262)2.89121757
79regulation of chromosome segregation (GO:0051983)2.88143654
80maturation of SSU-rRNA (GO:0030490)2.85524042
81spindle assembly checkpoint (GO:0071173)2.82378835
82regulation of histone H3-K9 methylation (GO:0051570)2.82226381
83maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.81642131
84translesion synthesis (GO:0019985)2.81177868
85chromosome condensation (GO:0030261)2.80923789
86regulation of mitotic metaphase/anaphase transition (GO:0030071)2.80661544
87negative regulation of chromosome segregation (GO:0051985)2.79483478
88DNA synthesis involved in DNA repair (GO:0000731)2.79056355
89negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.78682469
90negative regulation of sister chromatid segregation (GO:0033046)2.78682469
91negative regulation of mitotic sister chromatid separation (GO:2000816)2.78682469
92negative regulation of mitotic sister chromatid segregation (GO:0033048)2.78682469
93formation of translation preinitiation complex (GO:0001731)2.77856749
94regulation of B cell receptor signaling pathway (GO:0050855)2.76795566
95somatic cell DNA recombination (GO:0016444)2.76168173
96somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.76168173
97postreplication repair (GO:0006301)2.75847995
98positive regulation of mitotic sister chromatid separation (GO:1901970)2.75462403
99positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.75462403
100positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.75462403
101regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.75287706
102establishment of integrated proviral latency (GO:0075713)2.74516073
103V(D)J recombination (GO:0033151)2.74394416
104negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.71786299
105negative regulation of DNA recombination (GO:0045910)2.70802959
106regulation of DNA endoreduplication (GO:0032875)2.70297641
107mitotic cell cycle (GO:0000278)2.69717885
108DNA packaging (GO:0006323)2.68948973
109base-excision repair (GO:0006284)2.68783224
110mitotic spindle assembly checkpoint (GO:0007094)2.68635346
111regulation of mitotic spindle organization (GO:0060236)2.67875758
112dosage compensation (GO:0007549)2.67558182
113mitotic spindle checkpoint (GO:0071174)2.66571147
114regulation of mitotic sister chromatid separation (GO:0010965)2.65973066
115regulation of mitotic sister chromatid segregation (GO:0033047)2.65973066
116regulation of sister chromatid segregation (GO:0033045)2.65973066
117DNA replication (GO:0006260)2.64829749
118transcription-coupled nucleotide-excision repair (GO:0006283)2.63736987
119folic acid-containing compound biosynthetic process (GO:0009396)2.63167803
120sister chromatid cohesion (GO:0007062)2.62827749

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXM1_23109430_ChIP-Seq_U2OS_Human4.95551485
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.17029236
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.50345735
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.20549500
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.03314770
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.66224250
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.41986222
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.41064787
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.29141066
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.26030184
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.22288445
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.17968631
13E2F1_21310950_ChIP-Seq_MCF-7_Human2.15897420
14SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.14623833
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.13467113
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.08551179
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.08533956
18AR_21909140_ChIP-Seq_LNCAP_Human2.06480021
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.04727522
20VDR_23849224_ChIP-Seq_CD4+_Human2.01441777
21E2F7_22180533_ChIP-Seq_HELA_Human10.2871438
22MYC_22102868_ChIP-Seq_BL_Human1.97425106
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.95829839
24* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.93126402
25ETS1_20019798_ChIP-Seq_JURKAT_Human1.92325145
26FOXP3_21729870_ChIP-Seq_TREG_Human1.90507685
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.86431398
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.86144600
29XRN2_22483619_ChIP-Seq_HELA_Human1.84887019
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.80787639
31HOXB4_20404135_ChIP-ChIP_EML_Mouse1.76712440
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.72380011
33TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.72218520
34CIITA_25753668_ChIP-Seq_RAJI_Human1.72043749
35ELK1_19687146_ChIP-ChIP_HELA_Human1.70161661
36* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.69313223
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66419665
38IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.63883489
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.62512343
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.60722577
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.57204333
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56956645
43GATA1_22025678_ChIP-Seq_K562_Human1.55325847
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.54080945
45MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.53098364
46DCP1A_22483619_ChIP-Seq_HELA_Human1.52673691
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.51820599
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.51772652
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.51352658
50FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.49756185
51SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.48517981
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47343707
53ERG_20887958_ChIP-Seq_HPC-7_Mouse1.46006818
54SPI1_23547873_ChIP-Seq_NB4_Human1.43061988
55VDR_21846776_ChIP-Seq_THP-1_Human1.42010534
56* TTF2_22483619_ChIP-Seq_HELA_Human1.41806827
57GABP_19822575_ChIP-Seq_HepG2_Human1.41593877
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38426249
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38318765
60HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.33471247
61SCL_19346495_ChIP-Seq_HPC-7_Human1.32259903
62NANOG_18555785_ChIP-Seq_MESCs_Mouse1.28944159
63* MYB_26560356_Chip-Seq_TH2_Human1.28767857
64KDM5A_27292631_Chip-Seq_BREAST_Human1.26824276
65THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25676696
66STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.24672592
67* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.23782827
68E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.23268343
69FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.22473777
70IRF8_22096565_ChIP-ChIP_GC-B_Human1.22245651
71STAT4_19710469_ChIP-ChIP_TH1__Mouse1.21282827
72MYB_26560356_Chip-Seq_TH1_Human1.19012212
73ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17969354
74TP63_19390658_ChIP-ChIP_HaCaT_Human1.17301866
75* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.16973055
76SRF_21415370_ChIP-Seq_HL-1_Mouse1.16722607
77PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.14893984
78* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14028093
79* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.13131915
80PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12528332
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.11465430
82ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.09831734
83CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08614762
84NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.07338999
85* MAF_26560356_Chip-Seq_TH1_Human1.06657529
86CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05134079
87TFEB_21752829_ChIP-Seq_HELA_Human1.04601004
88UTX_26944678_Chip-Seq_JUKART_Human1.04001203
89RUNX1_22412390_ChIP-Seq_EML_Mouse1.03566822
90* IRF8_21731497_ChIP-ChIP_J774_Mouse1.01398541
91YY1_21170310_ChIP-Seq_MESCs_Mouse0.99138535
92RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.98785948
93CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97266385
94MYC_18940864_ChIP-ChIP_HL60_Human0.91351093
95SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.91191229
96KLF4_18555785_ChIP-Seq_MESCs_Mouse0.90758423
97FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.90111792
98* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.90073500
99STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.89970900
100GATA2_22383799_ChIP-Seq_G1ME_Mouse0.87863105
101CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.87401335
102SOX2_18555785_ChIP-Seq_MESCs_Mouse0.86891878
103* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.86580563
104RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.85747903
105* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.84964335
106SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.84621113
107PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.83788336
108* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83711554
109VDR_24763502_ChIP-Seq_THP-1_Human0.83670960
110* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.80692724
111RBPJ_22232070_ChIP-Seq_NCS_Mouse0.80318719
112STAT3_1855785_ChIP-Seq_MESCs_Mouse0.79773373
113CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.79100286
114CHD1_26751641_Chip-Seq_LNCaP_Human0.78434384
115GATA3_27048872_Chip-Seq_THYMUS_Human0.77394344

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.51423987
2MP0003693_abnormal_embryo_hatching4.28510953
3MP0008057_abnormal_DNA_replication4.12106172
4* MP0003111_abnormal_nucleus_morphology3.68048606
5MP0003077_abnormal_cell_cycle3.55428197
6MP0002396_abnormal_hematopoietic_system3.38093516
7MP0004957_abnormal_blastocyst_morpholog3.31960612
8MP0008058_abnormal_DNA_repair2.97066823
9MP0008007_abnormal_cellular_replicative2.70493954
10MP0003763_abnormal_thymus_physiology2.44573119
11MP0004808_abnormal_hematopoietic_stem2.19540691
12MP0001835_abnormal_antigen_presentation2.03251922
13MP0008877_abnormal_DNA_methylation2.02908008
14* MP0002398_abnormal_bone_marrow1.98051305
15MP0009697_abnormal_copulation1.91217758
16MP0000490_abnormal_crypts_of1.89086399
17MP0005671_abnormal_response_to1.86578170
18MP0008932_abnormal_embryonic_tissue1.83861638
19MP0010352_gastrointestinal_tract_polyps1.83672554
20MP0006054_spinal_hemorrhage1.82885858
21MP0003786_premature_aging1.81630503
22MP0000350_abnormal_cell_proliferation1.78603773
23MP0010307_abnormal_tumor_latency1.74545846
24MP0005397_hematopoietic_system_phenotyp1.74227796
25MP0001545_abnormal_hematopoietic_system1.74227796
26MP0001730_embryonic_growth_arrest1.71878396
27MP0000703_abnormal_thymus_morphology1.71638287
28MP0009333_abnormal_splenocyte_physiolog1.71339060
29MP0001800_abnormal_humoral_immune1.70381306
30* MP0002722_abnormal_immune_system1.68055766
31* MP0000689_abnormal_spleen_morphology1.67777966
32MP0003221_abnormal_cardiomyocyte_apopto1.60695570
33MP0002420_abnormal_adaptive_immunity1.59227929
34MP0003123_paternal_imprinting1.58850589
35MP0002019_abnormal_tumor_incidence1.57410934
36MP0001819_abnormal_immune_cell1.56094378
37* MP0000716_abnormal_immune_system1.50832881
38MP0002452_abnormal_antigen_presenting1.50714385
39* MP0002429_abnormal_blood_cell1.49981270
40MP0002166_altered_tumor_susceptibility1.43306770
41MP0003724_increased_susceptibility_to1.41232760
42MP0009785_altered_susceptibility_to1.40707478
43MP0000685_abnormal_immune_system1.36941418
44MP0002723_abnormal_immune_serum1.33697405
45MP0002132_abnormal_respiratory_system1.33680407
46MP0004147_increased_porphyrin_level1.30872647
47* MP0000313_abnormal_cell_death1.30822525
48MP0005380_embryogenesis_phenotype1.30749927
49MP0001672_abnormal_embryogenesis/_devel1.30749927
50MP0003890_abnormal_embryonic-extraembry1.30284167
51MP0008260_abnormal_autophagy1.28943625
52MP0002405_respiratory_system_inflammati1.28159045
53MP0000465_gastrointestinal_hemorrhage1.27671195
54MP0001697_abnormal_embryo_size1.27078271
55MP0005025_abnormal_response_to1.24591172
56MP0003436_decreased_susceptibility_to1.24480543
57MP0005000_abnormal_immune_tolerance1.23564924
58MP0009278_abnormal_bone_marrow1.22483578
59MP0003984_embryonic_growth_retardation1.22177827
60MP0002006_tumorigenesis1.20793669
61MP0001853_heart_inflammation1.18578887
62MP0002088_abnormal_embryonic_growth/wei1.18520488
63MP0010155_abnormal_intestine_physiology1.16680125
64MP0005464_abnormal_platelet_physiology1.16426222
65MP0003121_genomic_imprinting1.16192368
66* MP0002080_prenatal_lethality1.16083446
67MP0000858_altered_metastatic_potential1.15368165
68MP0002086_abnormal_extraembryonic_tissu1.12689161
69MP0003303_peritoneal_inflammation1.11982783
70MP0005075_abnormal_melanosome_morpholog1.11691543
71MP0002419_abnormal_innate_immunity1.11680677
72MP0002877_abnormal_melanocyte_morpholog1.09997418
73MP0001790_abnormal_immune_system1.09477430
74MP0005387_immune_system_phenotype1.09477430
75MP0006035_abnormal_mitochondrial_morpho1.06943282
76MP0005451_abnormal_body_composition1.05365328
77MP0001873_stomach_inflammation1.00890390
78MP0004197_abnormal_fetal_growth/weight/1.00526036
79MP0003567_abnormal_fetal_cardiomyocyte1.00067921
80MP0005076_abnormal_cell_differentiation0.98780643
81MP0000569_abnormal_digit_pigmentation0.97497184
82MP0002148_abnormal_hypersensitivity_rea0.96981024
83MP0002095_abnormal_skin_pigmentation0.96702433
84MP0003943_abnormal_hepatobiliary_system0.95634955
85MP0002085_abnormal_embryonic_tissue0.95203236
86MP0003656_abnormal_erythrocyte_physiolo0.89151233
87MP0002210_abnormal_sex_determination0.88016725
88MP0006292_abnormal_olfactory_placode0.87383285
89MP0003806_abnormal_nucleotide_metabolis0.86155455
90MP0002009_preneoplasia0.85122854
91MP0005023_abnormal_wound_healing0.84317448
92MP0003300_gastrointestinal_ulcer0.82944222
93MP0001293_anophthalmia0.82939415
94MP0005174_abnormal_tail_pigmentation0.82642963
95MP0002084_abnormal_developmental_patter0.81800886
96MP0000015_abnormal_ear_pigmentation0.80071522
97MP0001845_abnormal_inflammatory_respons0.79172420
98MP0003866_abnormal_defecation0.75385834
99MP0003448_altered_tumor_morphology0.74893102
100* MP0001119_abnormal_female_reproductive0.74127595
101MP0009672_abnormal_birth_weight0.73741748
102MP0001929_abnormal_gametogenesis0.73308910
103MP0005310_abnormal_salivary_gland0.73252474
104MP0001915_intracranial_hemorrhage0.72682777
105* MP0001145_abnormal_male_reproductive0.72299958
106MP0004185_abnormal_adipocyte_glucose0.70886240
107MP0005621_abnormal_cell_physiology0.67889299
108MP0000477_abnormal_intestine_morphology0.67093804
109MP0000598_abnormal_liver_morphology0.66715070
110MP0004947_skin_inflammation0.65879711
111MP0005384_cellular_phenotype0.65750688
112MP0001286_abnormal_eye_development0.64733564
113* MP0000653_abnormal_sex_gland0.63441023
114MP0003186_abnormal_redox_activity0.63375596
115MP0004381_abnormal_hair_follicle0.63139729
116MP0002933_joint_inflammation0.62626758
117MP0005389_reproductive_system_phenotype0.61525686
118MP0004264_abnormal_extraembryonic_tissu0.59481683
119MP0003566_abnormal_cell_adhesion0.58551568
120MP0003718_maternal_effect0.58551349

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.70798911
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.42454773
3Birth length less than 3rd percentile (HP:0003561)4.01789149
4Reticulocytopenia (HP:0001896)3.72431526
5Abnormality of chromosome stability (HP:0003220)3.66353441
6IgM deficiency (HP:0002850)3.42939030
7Meckel diverticulum (HP:0002245)3.18823828
8Myelodysplasia (HP:0002863)3.17975075
9Abnormality of the preputium (HP:0100587)3.14159957
10Abnormality of the ileum (HP:0001549)3.05347575
11Thrombocytosis (HP:0001894)3.00519959
12Aplastic anemia (HP:0001915)2.92047743
13Aplasia/Hypoplasia of the uvula (HP:0010293)2.89989244
14T lymphocytopenia (HP:0005403)2.89655010
15Hypochromic microcytic anemia (HP:0004840)2.88800024
16Abnormal number of erythroid precursors (HP:0012131)2.87376304
17Cortical dysplasia (HP:0002539)2.85215311
18Recurrent viral infections (HP:0004429)2.84452360
19Ectopic kidney (HP:0000086)2.82470581
20Abnormality of cells of the erythroid lineage (HP:0012130)2.75901765
21Small intestinal stenosis (HP:0012848)2.74470598
22Duodenal stenosis (HP:0100867)2.74470598
23Lymphoma (HP:0002665)2.73263799
24Abnormality of T cell number (HP:0011839)2.71444181
25Duplicated collecting system (HP:0000081)2.68662393
26Abnormality of T cells (HP:0002843)2.68319126
27Patellar aplasia (HP:0006443)2.67013409
28Colon cancer (HP:0003003)2.63621375
29B lymphocytopenia (HP:0010976)2.63090800
30Abnormality of B cell number (HP:0010975)2.63090800
31Medulloblastoma (HP:0002885)2.62910736
32Agnosia (HP:0010524)2.62775806
33Chronic mucocutaneous candidiasis (HP:0002728)2.59073162
34Recurrent cutaneous fungal infections (HP:0011370)2.59073162
35Panhypogammaglobulinemia (HP:0003139)2.58415194
36Combined immunodeficiency (HP:0005387)2.55605540
37Absent thumb (HP:0009777)2.53817774
38Clubbing of toes (HP:0100760)2.52519834
39Abnormality of the renal collecting system (HP:0004742)2.48599936
40Aplasia/Hypoplasia of the patella (HP:0006498)2.47539423
41Volvulus (HP:0002580)2.47048056
42Breast hypoplasia (HP:0003187)2.46369053
43Selective tooth agenesis (HP:0001592)2.44888695
44Basal cell carcinoma (HP:0002671)2.43147012
45* Bone marrow hypocellularity (HP:0005528)2.40748596
46Abnormality of T cell physiology (HP:0011840)2.40420839
47Severe combined immunodeficiency (HP:0004430)2.40348149
48IgG deficiency (HP:0004315)2.40262702
49Recurrent abscess formation (HP:0002722)2.40201880
50Amaurosis fugax (HP:0100576)2.39692494
51Recurrent bronchitis (HP:0002837)2.38478162
52Abnormality of DNA repair (HP:0003254)2.36389709
53Degeneration of anterior horn cells (HP:0002398)2.34972746
54Abnormality of the anterior horn cell (HP:0006802)2.34972746
55Poikilocytosis (HP:0004447)2.34851720
56Chronic otitis media (HP:0000389)2.34671496
57Autoimmune hemolytic anemia (HP:0001890)2.33185087
58Hypoplasia of the thymus (HP:0000778)2.33121108
59Abnormality of the fingertips (HP:0001211)2.32062889
60Carpal bone hypoplasia (HP:0001498)2.31877071
61Cellulitis (HP:0100658)2.31683525
62Petechiae (HP:0000967)2.30919263
63Abnormality of the heme biosynthetic pathway (HP:0010472)2.30487240
64Viral hepatitis (HP:0006562)2.29124760
65Oral leukoplakia (HP:0002745)2.28801338
66Acute myeloid leukemia (HP:0004808)2.27916492
67Thyroiditis (HP:0100646)2.27673653
68Nephroblastoma (Wilms tumor) (HP:0002667)2.27151754
69Agammaglobulinemia (HP:0004432)2.27131353
70Impulsivity (HP:0100710)2.27010654
71Acute lymphatic leukemia (HP:0006721)2.25227926
72Cutaneous melanoma (HP:0012056)2.25098231
73Myositis (HP:0100614)2.23451688
74Meningitis (HP:0001287)2.22779033
75Sloping forehead (HP:0000340)2.21852662
76Elevated erythrocyte sedimentation rate (HP:0003565)2.20143801
77Abnormality of the duodenum (HP:0002246)2.19498090
78Abnormality of the prostate (HP:0008775)2.18510830
79Eczematoid dermatitis (HP:0000976)2.16718490
80Deep philtrum (HP:0002002)2.13277099
81Embryonal renal neoplasm (HP:0011794)2.11232690
82Granulocytopenia (HP:0001913)2.10890229
83Squamous cell carcinoma (HP:0002860)2.09660660
84Abnormality of the carotid arteries (HP:0005344)2.09312769
85Lymphopenia (HP:0001888)2.08945358
86Cellular immunodeficiency (HP:0005374)2.08080015
87Abnormality of cells of the lymphoid lineage (HP:0012140)2.07590103
88Premature graying of hair (HP:0002216)2.07079842
89Progressive external ophthalmoplegia (HP:0000590)2.06893017
90Recurrent fungal infections (HP:0002841)2.06377340
91Hypoplasia of the capital femoral epiphysis (HP:0003090)2.06326978
92Microvesicular hepatic steatosis (HP:0001414)2.03289686
93Increased nuchal translucency (HP:0010880)2.02411897
94Cafe-au-lait spot (HP:0000957)2.01707029
95Abnormal delayed hypersensitivity skin test (HP:0002963)2.01336476
96Hypochromic anemia (HP:0001931)2.00282332
97Abnormal number of incisors (HP:0011064)2.00164056
98Acanthocytosis (HP:0001927)1.99738476
99Embryonal neoplasm (HP:0002898)1.99613167
100Eosinophilia (HP:0001880)1.99355399
101* Encephalitis (HP:0002383)1.97847456
102* Abnormal lung lobation (HP:0002101)1.97020506
103Obstructive lung disease (HP:0006536)1.95738661
104Chronic obstructive pulmonary disease (HP:0006510)1.95738661
105Absent radius (HP:0003974)1.94638208
106Abnormality of the thymus (HP:0000777)1.94307781
107Rhabdomyosarcoma (HP:0002859)1.92949407
108Recurrent bacterial skin infections (HP:0005406)1.91808755
109Recurrent skin infections (HP:0001581)1.90734220
110Ependymoma (HP:0002888)1.89485366
111Abnormality of eosinophils (HP:0001879)1.89321386
112Deviation of the thumb (HP:0009603)1.89262126
113Neoplasm of the pancreas (HP:0002894)1.89207169
114Cutis marmorata (HP:0000965)1.88967250
115Poikiloderma (HP:0001029)1.88960380
116Leukopenia (HP:0001882)1.88903836
117Syringomyelia (HP:0003396)1.88828181
118Spinal cord lesions (HP:0100561)1.88828181
119IgA deficiency (HP:0002720)1.88167986
120Tracheoesophageal fistula (HP:0002575)1.86762669
121Pancytopenia (HP:0001876)1.85735545
122Proximal placement of thumb (HP:0009623)1.85715251
123Aplasia/Hypoplasia of the thymus (HP:0010515)1.85258405
124High pitched voice (HP:0001620)1.85119855
125Overlapping toe (HP:0001845)1.84918421
126Stomatitis (HP:0010280)1.83141265
127Pallor (HP:0000980)1.80659126
128Malignant gastrointestinal tract tumors (HP:0006749)1.79898298
129Gastrointestinal carcinoma (HP:0002672)1.79898298
130Acute hepatic failure (HP:0006554)1.79482811
131Urticaria (HP:0001025)1.78109546
132Prominent nose (HP:0000448)1.76431629
133Leukocytosis (HP:0001974)1.75786475
134Microcytic anemia (HP:0001935)1.75717073
135Transitional cell carcinoma of the bladder (HP:0006740)1.75658418
136Neoplasm of the colon (HP:0100273)1.75609961
137Arteriovenous malformation (HP:0100026)1.71786438
138Gastrointestinal infarctions (HP:0005244)1.71402836
139Facial hemangioma (HP:0000329)1.69575442
140Bladder carcinoma (HP:0002862)1.68793769
141Bladder neoplasm (HP:0009725)1.68793769

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.05936685
2BUB13.48584171
3WEE13.38080474
4BRSK22.70214705
5MAP4K12.54366261
6NEK22.51643923
7EIF2AK12.37262335
8STK102.34018230
9SRPK12.18882236
10PASK2.01267124
11ACVR1B2.00762480
12TTK1.95432292
13PBK1.87858642
14VRK11.83922888
15RIPK41.82956656
16PLK41.80217420
17NEK11.74141981
18STK41.74103873
19TXK1.71840209
20PLK11.70053053
21CCNB11.68019008
22ATR1.67080890
23MKNK11.66467672
24BRSK11.62308523
25TEC1.58200707
26AURKB1.58002594
27EIF2AK31.52403783
28BTK1.47512010
29ZAK1.46008877
30TSSK61.45952071
31EEF2K1.45466686
32PLK31.39893652
33TAF11.39877845
34TLK11.38358702
35SMG11.36797420
36IRAK41.36475201
37RPS6KB21.34591471
38TESK21.34001327
39CDK71.30035363
40STK161.29385088
41PIM11.27351633
42MKNK21.26660882
43CDK41.26199067
44TGFBR11.25604735
45RPS6KA41.23184441
46FLT31.22030376
47CDK121.19409167
48MAP3K101.17421253
49MAP3K81.15917859
50CHEK21.15284316
51JAK31.14895701
52PRPF4B1.12495528
53NME21.10106037
54ITK1.07209223
55CHEK11.06199377
56GRK61.05575242
57MAP3K141.05510443
58KIT1.03275064
59ZAP701.01674708
60RAF11.01193136
61BLK1.00283365
62MST40.99921334
63MAP2K30.99248516
64MELK0.98798469
65TRIM280.97330036
66KSR10.93778812
67KSR20.92552702
68FES0.90464556
69ATM0.88083440
70BCR0.87940435
71CSF1R0.86815264
72DYRK30.86380048
73LRRK20.85921091
74TYK20.84096903
75TRPM70.80602006
76CDK80.78203430
77EIF2AK20.78187827
78PAK40.77364262
79SIK30.77304932
80SYK0.75042800
81AURKA0.74117885
82JAK20.69382424
83MARK30.68451874
84NEK90.66783404
85PKN20.66717312
86BRD40.66644798
87CDK30.66388463
88* CDK20.66378561
89KDR0.66037153
90SCYL20.64187226
91LCK0.63987515
92CDK60.63108114
93VRK20.62293215
94LYN0.61020982
95FGR0.60183214
96IRAK20.58400915
97BRAF0.55186888
98RPS6KA50.53193496
99STK30.52501577
100* CDK10.52193845
101NUAK10.52021834
102CSNK2A10.51870323
103STK240.51172677
104IRAK10.50085975
105NLK0.49998949
106CHUK0.46233239
107CSNK2A20.46125109
108IKBKB0.42957166
109CSK0.42180242
110IKBKE0.39605564
111PNCK0.39345958
112YES10.38738301
113EPHA20.38415390
114MAPKAPK20.38145415
115TESK10.37525033
116ALK0.37346653
117PIM20.35981763
118ERBB30.34237359
119HCK0.34029156
120MAPK110.33758262
121MAP3K20.31823337
122FGFR30.26685499
123PRKDC0.26209089
124MAP3K50.25201292

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.07282437
2Mismatch repair_Homo sapiens_hsa034304.34737481
3Base excision repair_Homo sapiens_hsa034103.36387513
4Homologous recombination_Homo sapiens_hsa034403.19492976
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.82819474
6Cell cycle_Homo sapiens_hsa041102.82062830
7Spliceosome_Homo sapiens_hsa030402.78685457
8Nucleotide excision repair_Homo sapiens_hsa034202.71137896
9Non-homologous end-joining_Homo sapiens_hsa034502.64468738
10Fanconi anemia pathway_Homo sapiens_hsa034602.48433107
11RNA transport_Homo sapiens_hsa030132.42010111
12Ribosome_Homo sapiens_hsa030102.31619835
13One carbon pool by folate_Homo sapiens_hsa006702.24442898
14RNA polymerase_Homo sapiens_hsa030202.24237714
15Primary immunodeficiency_Homo sapiens_hsa053402.14663009
16Proteasome_Homo sapiens_hsa030502.06140772
17Pyrimidine metabolism_Homo sapiens_hsa002402.03868737
18RNA degradation_Homo sapiens_hsa030181.91531510
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.74319941
20Basal transcription factors_Homo sapiens_hsa030221.72159326
21p53 signaling pathway_Homo sapiens_hsa041151.61199506
22mRNA surveillance pathway_Homo sapiens_hsa030151.58554210
23Antigen processing and presentation_Homo sapiens_hsa046121.46480521
24Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.46276727
25Systemic lupus erythematosus_Homo sapiens_hsa053221.46243395
26Herpes simplex infection_Homo sapiens_hsa051681.34517999
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29842535
28Epstein-Barr virus infection_Homo sapiens_hsa051691.16434561
29Viral carcinogenesis_Homo sapiens_hsa052031.14199112
30Purine metabolism_Homo sapiens_hsa002301.09247087
31Measles_Homo sapiens_hsa051621.08333489
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.05321328
33Hematopoietic cell lineage_Homo sapiens_hsa046401.02128034
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.00826599
35HTLV-I infection_Homo sapiens_hsa051660.95262443
36Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93276356
37Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89712865
38B cell receptor signaling pathway_Homo sapiens_hsa046620.88323105
39Leishmaniasis_Homo sapiens_hsa051400.83949227
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.83172281
41Legionellosis_Homo sapiens_hsa051340.79603426
42Protein export_Homo sapiens_hsa030600.78114201
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76364890
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74810272
45Oocyte meiosis_Homo sapiens_hsa041140.74060385
46Hepatitis B_Homo sapiens_hsa051610.73109439
47Small cell lung cancer_Homo sapiens_hsa052220.72292837
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72102673
49Apoptosis_Homo sapiens_hsa042100.70349127
50T cell receptor signaling pathway_Homo sapiens_hsa046600.69791772
51MicroRNAs in cancer_Homo sapiens_hsa052060.69707352
52Thyroid cancer_Homo sapiens_hsa052160.68323856
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.67284863
54Pentose phosphate pathway_Homo sapiens_hsa000300.65489931
55Influenza A_Homo sapiens_hsa051640.63663517
56Viral myocarditis_Homo sapiens_hsa054160.61324560
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61244459
58Shigellosis_Homo sapiens_hsa051310.60936034
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.59402826
60Tuberculosis_Homo sapiens_hsa051520.58701072
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58146572
62Biosynthesis of amino acids_Homo sapiens_hsa012300.56888281
63NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56133340
64Endometrial cancer_Homo sapiens_hsa052130.55641644
65N-Glycan biosynthesis_Homo sapiens_hsa005100.54543561
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.54050030
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53835986
68Jak-STAT signaling pathway_Homo sapiens_hsa046300.53827003
69Colorectal cancer_Homo sapiens_hsa052100.53053126
70Chronic myeloid leukemia_Homo sapiens_hsa052200.52576049
71Graft-versus-host disease_Homo sapiens_hsa053320.52125556
72Renal cell carcinoma_Homo sapiens_hsa052110.50584569
73Allograft rejection_Homo sapiens_hsa053300.50549783
74Steroid biosynthesis_Homo sapiens_hsa001000.50464439
75Acute myeloid leukemia_Homo sapiens_hsa052210.49409963
76Selenocompound metabolism_Homo sapiens_hsa004500.47484982
77Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47103894
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46214777
79Pancreatic cancer_Homo sapiens_hsa052120.46135992
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45874679
81Alcoholism_Homo sapiens_hsa050340.43623160
82Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42812627
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42063870
84Lysine degradation_Homo sapiens_hsa003100.41969523
85Non-small cell lung cancer_Homo sapiens_hsa052230.41510177
86Osteoclast differentiation_Homo sapiens_hsa043800.41075869
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40644551
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40378419
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.39502884
90Toxoplasmosis_Homo sapiens_hsa051450.38922396
91Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.38127409
92Platelet activation_Homo sapiens_hsa046110.37272037
93Asthma_Homo sapiens_hsa053100.36108049
94Notch signaling pathway_Homo sapiens_hsa043300.35983725
95Carbon metabolism_Homo sapiens_hsa012000.35967851
96Propanoate metabolism_Homo sapiens_hsa006400.34049679
97Inositol phosphate metabolism_Homo sapiens_hsa005620.33325336
98Staphylococcus aureus infection_Homo sapiens_hsa051500.31332689
99Prostate cancer_Homo sapiens_hsa052150.29105900
100Vitamin B6 metabolism_Homo sapiens_hsa007500.28960325
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28835531
102Pathways in cancer_Homo sapiens_hsa052000.28138544
103Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.27907744
104Prolactin signaling pathway_Homo sapiens_hsa049170.27658735
105Autoimmune thyroid disease_Homo sapiens_hsa053200.26533065
106Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.26322221
107Glutathione metabolism_Homo sapiens_hsa004800.25754556
108FoxO signaling pathway_Homo sapiens_hsa040680.25705039
109TGF-beta signaling pathway_Homo sapiens_hsa043500.25476679
110Pertussis_Homo sapiens_hsa051330.23474479
111HIF-1 signaling pathway_Homo sapiens_hsa040660.22495021
112Toll-like receptor signaling pathway_Homo sapiens_hsa046200.21175510
113Malaria_Homo sapiens_hsa051440.20533106
114Adherens junction_Homo sapiens_hsa045200.20375500
115Cyanoamino acid metabolism_Homo sapiens_hsa004600.20330533
116Hepatitis C_Homo sapiens_hsa051600.20220631
117Chemokine signaling pathway_Homo sapiens_hsa040620.19152153

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