LASP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1low-density lipoprotein particle clearance (GO:0034383)3.92129982
2apoptotic cell clearance (GO:0043277)3.84015170
3trophectodermal cell differentiation (GO:0001829)3.77951493
4regulation of hippo signaling (GO:0035330)3.75743916
5regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.64166790
6epithelial cell-cell adhesion (GO:0090136)3.52193387
7heterochromatin organization (GO:0070828)3.49054686
8regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.47823153
9cell adhesion mediated by integrin (GO:0033627)3.42967267
10COPI coating of Golgi vesicle (GO:0048205)3.38193151
11Golgi transport vesicle coating (GO:0048200)3.38193151
12positive regulation of Cdc42 GTPase activity (GO:0043089)3.36330339
13regulation of extracellular matrix disassembly (GO:0010715)3.28526763
14maternal placenta development (GO:0001893)3.28316572
15pinocytosis (GO:0006907)3.27196916
16hepatocyte apoptotic process (GO:0097284)3.26487939
17endodermal cell differentiation (GO:0035987)3.11634850
18hypotonic response (GO:0006971)3.10270806
19pentose-phosphate shunt (GO:0006098)3.08805527
20embryonic process involved in female pregnancy (GO:0060136)3.05048106
21regulation of cholesterol homeostasis (GO:2000188)3.03312896
22positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.01817352
23cytoskeletal anchoring at plasma membrane (GO:0007016)3.01598981
24positive regulation of histone deacetylation (GO:0031065)2.99728930
25epithelial cell differentiation involved in prostate gland development (GO:0060742)2.96909661
26positive regulation of extracellular matrix organization (GO:1903055)2.95707488
27cell-substrate junction assembly (GO:0007044)2.94134024
28apoptotic process involved in morphogenesis (GO:0060561)2.93977371
29mannose metabolic process (GO:0006013)2.93940981
30adherens junction assembly (GO:0034333)2.93800807
31wound healing, spreading of epidermal cells (GO:0035313)2.92515476
32negative regulation of cell size (GO:0045792)2.91680079
33cell differentiation involved in embryonic placenta development (GO:0060706)2.88814801
34regulation of tight junction assembly (GO:2000810)2.87343712
35establishment of endothelial barrier (GO:0061028)2.85030009
36polarized epithelial cell differentiation (GO:0030859)2.84614734
37retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.83047061
38positive regulation of endothelial cell apoptotic process (GO:2000353)2.82550773
39basement membrane organization (GO:0071711)2.79989024
40negative regulation of erythrocyte differentiation (GO:0045647)2.79379272
41regulation of cholesterol storage (GO:0010885)2.77645662
42activation of Rac GTPase activity (GO:0032863)2.75887152
43positive regulation of SMAD protein import into nucleus (GO:0060391)2.74785939
44NADPH regeneration (GO:0006740)2.74475374
45skin morphogenesis (GO:0043589)2.73180909
46maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.69262824
47regulation of integrin activation (GO:0033623)2.67888111
48hippo signaling (GO:0035329)2.67087865
49regulation of SMAD protein import into nucleus (GO:0060390)2.66926648
50regulation of early endosome to late endosome transport (GO:2000641)2.66748636
51activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.66073012
52response to laminar fluid shear stress (GO:0034616)2.65097986
53intestinal epithelial cell development (GO:0060576)2.64865617
54hormone catabolic process (GO:0042447)2.63801123
55modulation by symbiont of host defense response (GO:0052031)2.63730830
56modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.63730830
57modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.63730830
58positive regulation by organism of defense response of other organism involved in symbiotic interact2.63730830
59modulation by symbiont of host immune response (GO:0052553)2.63730830
60positive regulation by symbiont of host defense response (GO:0052509)2.63730830
61positive regulation of receptor recycling (GO:0001921)2.62753998
62positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.62151537
63negative regulation of fatty acid transport (GO:2000192)2.62090640
64positive regulation of blood vessel endothelial cell migration (GO:0043536)2.62048465
65NLS-bearing protein import into nucleus (GO:0006607)2.61695386
66glucose 6-phosphate metabolic process (GO:0051156)2.58367390
67hemidesmosome assembly (GO:0031581)2.57080701
68protein retention in ER lumen (GO:0006621)2.57072362
69positive regulation of nuclease activity (GO:0032075)2.55647026
70cortical actin cytoskeleton organization (GO:0030866)2.55454803
71antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.54566464
72antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.54566464
73epoxygenase P450 pathway (GO:0019373)2.53999672
74actin filament depolymerization (GO:0030042)2.53508180
75intestinal absorption (GO:0050892)2.52273848
76regulation of extracellular matrix organization (GO:1903053)2.50958177
77L-alpha-amino acid transmembrane transport (GO:1902475)2.50896531
78stress fiber assembly (GO:0043149)2.50261062
79positive regulation of p38MAPK cascade (GO:1900745)2.50008725
80establishment of apical/basal cell polarity (GO:0035089)2.49518650
81Arp2/3 complex-mediated actin nucleation (GO:0034314)2.49385760
82branching involved in mammary gland duct morphogenesis (GO:0060444)2.48283362
83RNA stabilization (GO:0043489)2.47860046
84mRNA stabilization (GO:0048255)2.47860046
85platelet aggregation (GO:0070527)2.47816361
86antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.45937245
87membrane raft organization (GO:0031579)2.45867104
88focal adhesion assembly (GO:0048041)2.45723539
89cell-substrate adherens junction assembly (GO:0007045)2.45723539
90membrane protein ectodomain proteolysis (GO:0006509)2.45577116
91vagina development (GO:0060068)2.45489548
92regulation of gene silencing by miRNA (GO:0060964)2.44837620
93regulation of gene silencing by RNA (GO:0060966)2.44837620
94regulation of posttranscriptional gene silencing (GO:0060147)2.44837620
95morphogenesis of an endothelium (GO:0003159)2.44690494
96endothelial tube morphogenesis (GO:0061154)2.44690494
97negative regulation of protein localization to plasma membrane (GO:1903077)2.44145636
98negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.43230139
99substrate adhesion-dependent cell spreading (GO:0034446)2.42742048
100vitamin A metabolic process (GO:0006776)2.42450774
101sulfur amino acid catabolic process (GO:0000098)2.42405486
102positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.41974665
103response to peptidoglycan (GO:0032494)2.41847646
104branching involved in labyrinthine layer morphogenesis (GO:0060670)2.41832365
105actin filament bundle assembly (GO:0051017)2.40912215
106actin filament bundle organization (GO:0061572)2.40912215
107vesicle coating (GO:0006901)2.40337190
108positive regulation of protein deacetylation (GO:0090312)2.39397937
109labyrinthine layer blood vessel development (GO:0060716)2.38955895
110regulation of leukocyte degranulation (GO:0043300)2.38788808
111female genitalia development (GO:0030540)2.38679409
112negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.37800582
113negative regulation of cell killing (GO:0031342)2.37800582
114embryonic placenta development (GO:0001892)2.36438855
115regulation of nuclease activity (GO:0032069)2.34305154
116regulation of protein heterodimerization activity (GO:0043497)2.33994680
117endoplasmic reticulum unfolded protein response (GO:0030968)2.31607358
118vascular endothelial growth factor signaling pathway (GO:0038084)2.29644136
119substrate-dependent cell migration (GO:0006929)2.28846574
120desmosome organization (GO:0002934)2.28731471
121intestinal cholesterol absorption (GO:0030299)2.28283437
122modulation by symbiont of host cellular process (GO:0044068)2.27527897
123wound healing, spreading of cells (GO:0044319)2.26762927
124blood vessel endothelial cell migration (GO:0043534)2.26662178
125interferon-gamma secretion (GO:0072643)2.26188406
126negative regulation of smooth muscle cell migration (GO:0014912)2.25184647
127vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.24228272
128intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.24203673
129planar cell polarity pathway involved in neural tube closure (GO:0090179)2.23498369
130NIK/NF-kappaB signaling (GO:0038061)2.23430709
131cortical cytoskeleton organization (GO:0030865)2.22788212
132regulation of podosome assembly (GO:0071801)2.22757806
133glycosphingolipid catabolic process (GO:0046479)2.22486967
134semaphorin-plexin signaling pathway (GO:0071526)2.22079808
135detection of other organism (GO:0098543)2.21587873
136regulation of translational fidelity (GO:0006450)2.21064337
137peptide catabolic process (GO:0043171)2.19662086
138protein localization to endosome (GO:0036010)2.19621961
139protein localization to kinetochore (GO:0034501)2.19109623
140glucose catabolic process (GO:0006007)2.18909244
141hyaluronan catabolic process (GO:0030214)2.18610751
142regulation of apoptotic process involved in morphogenesis (GO:1902337)2.18583035
143regulation of glucose import in response to insulin stimulus (GO:2001273)2.18536557
144cellular response to unfolded protein (GO:0034620)2.18138399
145antigen processing and presentation of endogenous antigen (GO:0019883)2.18052451
146regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.17997288
147regulation of defense response to virus by virus (GO:0050690)2.17696576
148cellular response to vitamin (GO:0071295)2.17541693
149mammary gland epithelial cell proliferation (GO:0033598)2.17119931
150barbed-end actin filament capping (GO:0051016)2.16924229
151endocytic recycling (GO:0032456)2.16639002
152negative regulation of anoikis (GO:2000811)2.15955744
153regulation of superoxide anion generation (GO:0032928)2.15575754
154negative regulation of viral release from host cell (GO:1902187)2.15135540
155COPII vesicle coating (GO:0048208)2.15133490
156adhesion of symbiont to host (GO:0044406)2.14558249
157adhesion of symbiont to host cell (GO:0044650)2.14337423
158virion attachment to host cell (GO:0019062)2.14337423
159collagen fibril organization (GO:0030199)2.13808554

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.36169369
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.31830491
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.20447359
4RARG_19884340_ChIP-ChIP_MEFs_Mouse2.37325944
5POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.20673818
6* MYC_22102868_ChIP-Seq_BL_Human2.19850921
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.17637520
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.17637520
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.17637520
10ELK3_25401928_ChIP-Seq_HUVEC_Human2.12465060
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.12412868
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.05054467
13HIF1A_21447827_ChIP-Seq_MCF-7_Human2.01029669
14* CLOCK_20551151_ChIP-Seq_293T_Human1.99418379
15NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.98781619
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.96574645
17RACK7_27058665_Chip-Seq_MCF-7_Human1.81569002
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.80409202
19ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.79538538
20LXR_22292898_ChIP-Seq_THP-1_Human1.78776852
21* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.78302485
22* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.76463362
23TCF7_22412390_ChIP-Seq_EML_Mouse1.75183977
24ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.74941584
25* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.74521492
26ESR1_15608294_ChIP-ChIP_MCF-7_Human1.72405061
27FOXM1_23109430_ChIP-Seq_U2OS_Human1.68821981
28VDR_24763502_ChIP-Seq_THP-1_Human1.67371583
29* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.67128546
30* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.66695170
31* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.65543341
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.65145687
33* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.64098479
34STAT3_1855785_ChIP-Seq_MESCs_Mouse1.63706571
35* ATF3_27146783_Chip-Seq_COLON_Human1.61979471
36* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.61400276
37* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.60890369
38RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.60788489
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.59455993
40VDR_21846776_ChIP-Seq_THP-1_Human1.59256125
41CDX2_20551321_ChIP-Seq_CACO-2_Human1.58875322
42KDM2B_26808549_Chip-Seq_DND41_Human1.58346987
43RXR_22158963_ChIP-Seq_LIVER_Mouse1.56487373
44TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.54108395
45* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.53570672
46MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.52778854
47TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.50714090
48PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.48711148
49KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.48661823
50P300_27058665_Chip-Seq_ZR-75-30cells_Human1.48455201
51* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.45239091
52* RUNX1_22412390_ChIP-Seq_EML_Mouse1.43174139
53E2F7_22180533_ChIP-Seq_HELA_Human1.41043613
54SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.40019924
55FOXO3_23340844_ChIP-Seq_DLD1_Human1.38408864
56* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.37822820
57KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.35994307
58MYB_21317192_ChIP-Seq_ERMYB_Mouse1.35230479
59GATA6_25053715_ChIP-Seq_YYC3_Human1.31631790
60* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.31454751
61NCOR1_26117541_ChIP-Seq_K562_Human1.31012968
62EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.29730134
63* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.29171742
64* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.28340442
65ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.27968307
66SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.26286035
67GATA2_21666600_ChIP-Seq_HMVEC_Human1.25677178
68* KDM2B_26808549_Chip-Seq_JURKAT_Human1.24276267
69LXR_22158963_ChIP-Seq_LIVER_Mouse1.23447118
70RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.23237567
71ESR1_21235772_ChIP-Seq_MCF-7_Human1.21823420
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21574187
73CTCF_27219007_Chip-Seq_ERYTHROID_Human1.21278093
74TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20714269
75VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.20279110
76Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.20277416
77* MAF_26560356_Chip-Seq_TH1_Human1.19761458
78TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19689528
79TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19151081
80NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18729967
81GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17621246
82NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.15612847
83KDM2B_26808549_Chip-Seq_K562_Human1.15003189
84* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13974697
85IRF8_27001747_Chip-Seq_BMDM_Mouse1.13891548
86* UTX_26944678_Chip-Seq_JUKART_Human1.13803001
87* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.13337271
88* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13333573
89UBF1/2_26484160_Chip-Seq_HMECs_Human1.13059460
90* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.12995670
91STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12372426
92PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10953284
93* TP53_22127205_ChIP-Seq_IMR90_Human1.10792479
94THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10610519
95RUNX1_27514584_Chip-Seq_MCF-7_Human1.09819663
96IRF8_22096565_ChIP-ChIP_GC-B_Human1.09562340
97ZNF263_19887448_ChIP-Seq_K562_Human1.09017144
98P63_26484246_Chip-Seq_KERATINOCYTES_Human1.08255164
99BP1_19119308_ChIP-ChIP_Hs578T_Human1.07652229
100SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.07463404
101EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06764550
102* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.06548682
103TET1_21451524_ChIP-Seq_MESCs_Mouse1.06540966
104SOX9_24532713_ChIP-Seq_HFSC_Mouse1.06179165
105CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05759908
106* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.05597502
107SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.05554736
108SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.05554736
109* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.05527546
110* SA1_27219007_Chip-Seq_ERYTHROID_Human1.04698836
111NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.03873589
112* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.03866382
113GATA1_19941827_ChIP-Seq_MEL_Mouse1.03825324
114SPI1_23127762_ChIP-Seq_K562_Human1.03799003
115SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03779163
116STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.03494675
117* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03469292
118* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.03058663
119SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.02582523
120UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02457254
121AR_21909140_ChIP-Seq_LNCAP_Human1.02156152
122SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01637477
123NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.01159025
124* GATA4_25053715_ChIP-Seq_YYC3_Human1.01013740
125IRF8_21731497_ChIP-ChIP_J774_Mouse1.00515629
126STAT4_19710469_ChIP-ChIP_TH1__Mouse1.00430850
127GATA1_19941826_ChIP-Seq_K562_Human1.00224304
128FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.99681261
129KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99371001
130* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.99081223
131* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.98983003
132STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.98106380
133* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97761373

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.75239626
2MP0010352_gastrointestinal_tract_polyps3.37978649
3MP0004264_abnormal_extraembryonic_tissu3.11151150
4MP0003566_abnormal_cell_adhesion2.80942118
5MP0010234_abnormal_vibrissa_follicle2.61504634
6MP0008438_abnormal_cutaneous_collagen2.42125457
7MP0005451_abnormal_body_composition2.35785198
8MP0003300_gastrointestinal_ulcer2.30103653
9MP0005076_abnormal_cell_differentiation2.24081805
10MP0005023_abnormal_wound_healing2.17830672
11MP0002254_reproductive_system_inflammat1.99639734
12MP0009840_abnormal_foam_cell1.92015604
13MP0003303_peritoneal_inflammation1.83835110
14MP0004272_abnormal_basement_membrane1.77519422
15MP0001849_ear_inflammation1.69575741
16MP0005257_abnormal_intraocular_pressure1.67969402
17MP0005360_urolithiasis1.67662599
18MP0008260_abnormal_autophagy1.66402334
19MP0005409_darkened_coat_color1.65930857
20MP0003091_abnormal_cell_migration1.65148878
21MP0006054_spinal_hemorrhage1.64988468
22MP0003283_abnormal_digestive_organ1.61443200
23MP0005275_abnormal_skin_tensile1.53414128
24MP0002877_abnormal_melanocyte_morpholog1.51895942
25MP0003436_decreased_susceptibility_to1.49927528
26MP0000858_altered_metastatic_potential1.47179156
27MP0004858_abnormal_nervous_system1.44544798
28MP0009278_abnormal_bone_marrow1.42839558
29MP0003279_aneurysm1.41944092
30MP0002998_abnormal_bone_remodeling1.41605289
31MP0005623_abnormal_meninges_morphology1.38414343
32MP0003453_abnormal_keratinocyte_physiol1.35611937
33MP0002419_abnormal_innate_immunity1.31972446
34MP0004947_skin_inflammation1.29802928
35MP0009053_abnormal_anal_canal1.29554588
36MP0003828_pulmonary_edema1.25409097
37MP0003448_altered_tumor_morphology1.25094791
38MP0002086_abnormal_extraembryonic_tissu1.22915547
39MP0000537_abnormal_urethra_morphology1.22240476
40MP0001958_emphysema1.18680622
41MP0003724_increased_susceptibility_to1.17047895
42MP0000490_abnormal_crypts_of1.15348001
43MP0008961_abnormal_basal_metabolism1.14944569
44MP0010030_abnormal_orbit_morphology1.14719850
45MP0003329_amyloid_beta_deposits1.14557927
46MP0003950_abnormal_plasma_membrane1.13883920
47MP0005058_abnormal_lysosome_morphology1.11861832
48MP0003172_abnormal_lysosome_physiology1.11593250
49MP0010307_abnormal_tumor_latency1.11558475
50MP0004185_abnormal_adipocyte_glucose1.10883252
51MP0005164_abnormal_response_to1.10226105
52MP0003252_abnormal_bile_duct1.09613267
53MP0001348_abnormal_lacrimal_gland1.08962327
54MP0000477_abnormal_intestine_morphology1.08625196
55MP0006082_CNS_inflammation1.08352472
56MP0003191_abnormal_cellular_cholesterol1.07580223
57MP0005025_abnormal_response_to1.05667089
58MP0010155_abnormal_intestine_physiology1.03738062
59MP0001835_abnormal_antigen_presentation1.03332966
60MP0003183_abnormal_peptide_metabolism1.03069043
61MP0004197_abnormal_fetal_growth/weight/1.02783515
62MP0001666_abnormal_nutrient_absorption1.02318842
63MP0000604_amyloidosis1.01492773
64MP0002088_abnormal_embryonic_growth/wei1.01278660
65MP0001542_abnormal_bone_strength1.01115644
66MP0000733_abnormal_muscle_development1.00810975
67MP0003984_embryonic_growth_retardation1.00342084
68MP0005167_abnormal_blood-brain_barrier0.97107640
69MP0004883_abnormal_blood_vessel0.95754115
70MP0010329_abnormal_lipoprotein_level0.95617924
71MP0000609_abnormal_liver_physiology0.95328404
72MP0001672_abnormal_embryogenesis/_devel0.95062334
73MP0005380_embryogenesis_phenotype0.95062334
74MP0003075_altered_response_to0.94048578
75MP0001533_abnormal_skeleton_physiology0.92937972
76MP0001730_embryonic_growth_arrest0.92102015
77MP0002060_abnormal_skin_morphology0.91052393
78MP0005503_abnormal_tendon_morphology0.90743787
79MP0003045_fibrosis0.90082107
80MP0005387_immune_system_phenotype0.87624555
81MP0001790_abnormal_immune_system0.87624555
82MP0003795_abnormal_bone_structure0.87226504
83MP0005000_abnormal_immune_tolerance0.87035192
84MP0002796_impaired_skin_barrier0.87020819
85MP0003119_abnormal_digestive_system0.86781810
86MP0000350_abnormal_cell_proliferation0.86638174
87MP0000003_abnormal_adipose_tissue0.86574592
88MP0002925_abnormal_cardiovascular_devel0.86421066
89MP0005621_abnormal_cell_physiology0.85832934
90MP0002933_joint_inflammation0.85705365
91MP0010368_abnormal_lymphatic_system0.85357370
92MP0004233_abnormal_muscle_weight0.85248681
93MP0008004_abnormal_stomach_pH0.83974946
94MP0004510_myositis0.83436262
95MP0009785_altered_susceptibility_to0.81122510
96MP0005248_abnormal_Harderian_gland0.81018576
97MP0000678_abnormal_parathyroid_gland0.80887598
98MP0002396_abnormal_hematopoietic_system0.80879911
99MP0004957_abnormal_blastocyst_morpholog0.80616248
100MP0000249_abnormal_blood_vessel0.80351510
101MP0001915_intracranial_hemorrhage0.80182082
102MP0001243_abnormal_dermal_layer0.80170885
103MP0002084_abnormal_developmental_patter0.79632866
104MP0000516_abnormal_urinary_system0.78804778
105MP0005367_renal/urinary_system_phenotyp0.78804778
106MP0000685_abnormal_immune_system0.78541595
107MP0002452_abnormal_antigen_presenting0.78506658
108MP0000343_altered_response_to0.77804825
109MP0002139_abnormal_hepatobiliary_system0.77531109
110MP0000598_abnormal_liver_morphology0.77190949
111MP0002896_abnormal_bone_mineralization0.76319668
112MP0005165_increased_susceptibility_to0.75963585
113MP0005464_abnormal_platelet_physiology0.75432411
114MP0009384_cardiac_valve_regurgitation0.74988764
115MP0005390_skeleton_phenotype0.73921144
116MP0000767_abnormal_smooth_muscle0.73901482
117MP0002405_respiratory_system_inflammati0.73418290
118MP0005375_adipose_tissue_phenotype0.72347021
119MP0001819_abnormal_immune_cell0.72277357
120MP0000428_abnormal_craniofacial_morphol0.72109000
121MP0001614_abnormal_blood_vessel0.71640900
122MP0005508_abnormal_skeleton_morphology0.71633465
123MP0002420_abnormal_adaptive_immunity0.71426654
124MP0001697_abnormal_embryo_size0.71396738
125MP0001845_abnormal_inflammatory_respons0.70479154
126MP0001545_abnormal_hematopoietic_system0.69976028
127MP0005397_hematopoietic_system_phenotyp0.69976028
128MP0005501_abnormal_skin_physiology0.69736273
129MP0002089_abnormal_postnatal_growth/wei0.69436115
130MP0005666_abnormal_adipose_tissue0.69374096
131MP0002092_abnormal_eye_morphology0.69274376
132MP0005166_decreased_susceptibility_to0.69148865
133MP0001851_eye_inflammation0.69083458
134MP0009333_abnormal_splenocyte_physiolog0.68905877
135MP0005365_abnormal_bile_salt0.68354717
136MP0001216_abnormal_epidermal_layer0.68097470
137MP0002138_abnormal_hepatobiliary_system0.67918599
138MP0001873_stomach_inflammation0.67668143

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.05287089
2Cerebral aneurysm (HP:0004944)3.49957112
3Premature rupture of membranes (HP:0001788)3.32667614
4Peritonitis (HP:0002586)3.07016074
5Vascular tortuosity (HP:0004948)3.06486522
6Arterial tortuosity (HP:0005116)3.04770612
7Cervical subluxation (HP:0003308)3.02547471
8Hand muscle atrophy (HP:0009130)2.95574543
9Shallow orbits (HP:0000586)2.91132305
10Ankle contracture (HP:0006466)2.80255126
11Upper limb amyotrophy (HP:0009129)2.78946636
12Distal upper limb amyotrophy (HP:0007149)2.78946636
13Right ventricular cardiomyopathy (HP:0011663)2.71813561
14Distal lower limb amyotrophy (HP:0008944)2.66075910
15Micronodular cirrhosis (HP:0001413)2.60600261
16Mitral valve prolapse (HP:0001634)2.59649110
17Atrophic scars (HP:0001075)2.59154260
18Eczematoid dermatitis (HP:0000976)2.58115829
19Esophageal varix (HP:0002040)2.57849449
20Broad face (HP:0000283)2.52589441
21Increased connective tissue (HP:0009025)2.52090787
22Flat acetabular roof (HP:0003180)2.49631076
23Genu recurvatum (HP:0002816)2.49283652
24Spondylolisthesis (HP:0003302)2.48989251
25Dilatation of the ascending aorta (HP:0005111)2.41875426
26Wormian bones (HP:0002645)2.39834809
27Ulnar bowing (HP:0003031)2.36644536
28Spinal rigidity (HP:0003306)2.36003679
29Radial bowing (HP:0002986)2.34816780
30Disproportionate tall stature (HP:0001519)2.34706006
31Aneurysm (HP:0002617)2.33509961
32Aortic aneurysm (HP:0004942)2.31814542
33Hemorrhage of the eye (HP:0011885)2.31275745
34Aortic dissection (HP:0002647)2.29269295
35Short nail (HP:0001799)2.22686906
36Thin bony cortex (HP:0002753)2.22084159
37Abnormality of macrophages (HP:0004311)2.21879631
38Abnormality of the distal phalanx of the thumb (HP:0009617)2.20354657
39Multiple enchondromatosis (HP:0005701)2.19508231
40Abnormal cartilage morphology (HP:0002763)2.11806963
41Mitral regurgitation (HP:0001653)2.11438032
42Short humerus (HP:0005792)2.11113334
43Lymphangioma (HP:0100764)2.07321823
44Interstitial pulmonary disease (HP:0006530)2.05003623
45Increased mean platelet volume (HP:0011877)2.04806211
46Abnormality of the lower motor neuron (HP:0002366)2.04082886
47Hyperacusis (HP:0010780)2.02574515
48Cellulitis (HP:0100658)2.01991316
49Bowing of the arm (HP:0006488)2.01802435
50Bowed forearm bones (HP:0003956)2.01802435
51Selective tooth agenesis (HP:0001592)2.01594119
52Mucopolysacchariduria (HP:0008155)2.01186449
53Urinary glycosaminoglycan excretion (HP:0003541)2.01186449
54Fused cervical vertebrae (HP:0002949)1.99570543
55Distal lower limb muscle weakness (HP:0009053)1.99358765
56Abnormality of the distal phalanges of the toes (HP:0010182)1.99322833
57Myocardial infarction (HP:0001658)1.99312322
58Increased cerebral lipofuscin (HP:0011813)1.98297511
59Blue sclerae (HP:0000592)1.98238913
60Abnormal ossification of hand bones (HP:0005921)1.97790019
61Pseudobulbar signs (HP:0002200)1.96253701
62Gastrointestinal dysmotility (HP:0002579)1.95537543
63Ependymoma (HP:0002888)1.95241108
64Fragile skin (HP:0001030)1.94387984
65Joint laxity (HP:0001388)1.94258902
66Abnormality of carpal bone ossification (HP:0006257)1.93675770
67Bladder diverticulum (HP:0000015)1.93577333
68Mitral stenosis (HP:0001718)1.93085021
69Increased variability in muscle fiber diameter (HP:0003557)1.92496436
70Abnormality of dentin (HP:0010299)1.91663573
71Achilles tendon contracture (HP:0001771)1.91490802
72Subacute progressive viral hepatitis (HP:0006572)1.90948903
73Trismus (HP:0000211)1.90599533
74Abnormal platelet volume (HP:0011876)1.90546491
75Vertebral hypoplasia (HP:0008417)1.89603570
76Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.89603570
77Abnormality of glycolipid metabolism (HP:0010969)1.88953251
78Abnormality of liposaccharide metabolism (HP:0010968)1.88953251
79Abnormality of glycosphingolipid metabolism (HP:0004343)1.88953251
80Neonatal short-limb short stature (HP:0008921)1.88949152
81Abdominal distention (HP:0003270)1.88505233
82Biconcave vertebral bodies (HP:0004586)1.88434260
83Aplasia/hypoplasia of the humerus (HP:0006507)1.87826414
84Abnormality of the acetabulum (HP:0003170)1.86610240
85Spinal cord lesions (HP:0100561)1.85520472
86Syringomyelia (HP:0003396)1.85520472
87Abnormality of the Achilles tendon (HP:0005109)1.85355895
88Soft skin (HP:0000977)1.85180041
89Renal duplication (HP:0000075)1.83679528
90Increased density of long bones (HP:0006392)1.82963435
91Abnormality of mucopolysaccharide metabolism (HP:0011020)1.82912482
92Abnormality of polysaccharide metabolism (HP:0011012)1.82912482
93Abnormality of glycosaminoglycan metabolism (HP:0004371)1.82912482
94Coxa vara (HP:0002812)1.82429026
95Abnormality of skeletal muscle fiber size (HP:0012084)1.80709224
96Mildly elevated creatine phosphokinase (HP:0008180)1.79335009
97Hyperextensible skin (HP:0000974)1.78094328
98Lower limb amyotrophy (HP:0007210)1.77906358
99Hepatoblastoma (HP:0002884)1.75937050
100Gingivitis (HP:0000230)1.75289806
101Dysostosis multiplex (HP:0000943)1.74841830
102Long palpebral fissure (HP:0000637)1.74637044
103Spastic diplegia (HP:0001264)1.74609492
104Cupped ribs (HP:0000887)1.73597537
105Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.72978146
106Vertebral compression fractures (HP:0002953)1.72902538
107Skin nodule (HP:0200036)1.72612966
108Elbow flexion contracture (HP:0002987)1.72147839
109Xanthomatosis (HP:0000991)1.71401174
110Malignant gastrointestinal tract tumors (HP:0006749)1.71075023
111Gastrointestinal carcinoma (HP:0002672)1.71075023
112Broad metatarsal (HP:0001783)1.70994286
113Amyloidosis (HP:0011034)1.70043870
114Deep venous thrombosis (HP:0002625)1.69914276
115Abnormality of glutamine family amino acid metabolism (HP:0010902)1.69903789
116Osteolytic defects of the hand bones (HP:0009699)1.69830636
117Osteolytic defects of the phalanges of the hand (HP:0009771)1.69830636
118Abnormality of the peritoneum (HP:0002585)1.69793779
119Polycythemia (HP:0001901)1.69657180
120Bone pain (HP:0002653)1.69001374
121Abnormality of proline metabolism (HP:0010907)1.68854668
122Hydroxyprolinuria (HP:0003080)1.68854668
123Abnormality of the astrocytes (HP:0100707)1.68397864
124Astrocytoma (HP:0009592)1.68397864
125Back pain (HP:0003418)1.68383416
126Recurrent abscess formation (HP:0002722)1.67676849
127Slender build (HP:0001533)1.66431956
128Focal segmental glomerulosclerosis (HP:0000097)1.66127429
129Abnormality of oral frenula (HP:0000190)1.65920720
130Hallux valgus (HP:0001822)1.65517678
131Nonimmune hydrops fetalis (HP:0001790)1.65420631
132Hematochezia (HP:0002573)1.65160039
133Vertebral clefting (HP:0008428)1.65039430
134Deviation of the hallux (HP:0010051)1.64853138
135Missing ribs (HP:0000921)1.64695344
136Emphysema (HP:0002097)1.64430701
137Camptodactyly of toe (HP:0001836)1.64309572
138Menorrhagia (HP:0000132)1.64288625
139Abnormality of the nasal mucosa (HP:0000433)1.64160458
140Joint stiffness (HP:0001387)1.63767919
141Malnutrition (HP:0004395)1.63736032
142Asymmetry of the thorax (HP:0001555)1.62986759
143Spinal cord compression (HP:0002176)1.62719329
144Axonal loss (HP:0003447)1.62188419
145Bowel diverticulosis (HP:0005222)1.62091865
146Segmental peripheral demyelination/remyelination (HP:0003481)1.61600458
147Systemic lupus erythematosus (HP:0002725)1.60859069
148Abnormality of complement system (HP:0005339)1.59867187
149Striae distensae (HP:0001065)1.59449419
150Hypertriglyceridemia (HP:0002155)1.59397036
151Difficulty climbing stairs (HP:0003551)1.58613816
152Metaphyseal cupping (HP:0003021)1.58520055

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.18265376
2ERN14.15928409
3CDK123.74055132
4EPHA23.40446570
5PKN23.04106174
6PRPF4B2.77663467
7RIPK12.60634322
8SMG12.48139518
9STK102.31167822
10IRAK32.20728330
11PTK62.16791719
12PAK42.12904107
13GRK61.97011027
14MAP3K101.96195754
15TTN1.93995236
16EEF2K1.87567740
17PTK21.87336949
18PDGFRA1.85086695
19LRRK21.65984758
20TGFBR21.60728034
21DDR21.57102679
22TESK11.56343575
23SIK11.46009230
24BMX1.44764803
25RPS6KB21.41537499
26SCYL21.40654015
27TESK21.34199343
28CDC42BPA1.32463204
29RIPK41.31364554
30LATS11.24836657
31LATS21.24477992
32MAP3K131.21579445
33PRKD21.19032066
34EPHB11.16228645
35FGFR41.15595990
36CSK1.15207339
37TAOK11.14236761
38ALK1.08891896
39KDR1.08285397
40MTOR1.07163144
41NEK91.05782154
42PAK21.05334487
43MAP2K21.05215440
44IRAK41.03729339
45MAP3K141.02860262
46TYRO31.02077187
47MATK1.00688311
48MAP3K80.99975629
49EPHB20.99710588
50MYLK0.99528862
51TBK10.99248150
52CSF1R0.97510063
53MAP3K60.94074939
54STK380.93131623
55NEK10.88540914
56FRK0.87456316
57CDK60.86449960
58FER0.86130503
59MAP3K30.84672286
60MAP3K110.84541998
61MST40.82739522
62MARK20.82138005
63RPS6KA20.81974464
64RPS6KA40.81755984
65MAPKAPK30.81098608
66ICK0.81007353
67PDPK10.80937999
68MAP2K30.77062304
69SIK30.76751214
70MET0.76427119
71FLT30.74634409
72CAMK1D0.74281083
73KSR20.73775194
74DYRK1B0.71701736
75TAOK30.71472540
76BLK0.65372991
77MAP3K90.65343942
78TYK20.65294043
79FGFR30.64964003
80ZAP700.64358546
81NEK20.64173299
82MST1R0.63937897
83ERBB40.62595695
84FGR0.61028838
85MOS0.60931605
86MAP2K10.59716550
87MAP4K10.59528276
88LIMK10.59047912
89PDGFRB0.57550004
90ARAF0.57398980
91JAK30.57022195
92PRKCI0.56796454
93TGFBR10.56320338
94NME20.53586571
95ERBB20.51145712
96MAPK110.50087221
97STK30.50083442
98PAK30.50062345
99CDK40.49953462
100HIPK20.49885921
101FGFR10.49689802
102RPS6KC10.49004194
103RPS6KL10.49004194
104EGFR0.48390233
105MAP3K20.48347947
106PIM20.47669329
107CHUK0.46832272
108PLK40.46577389
109PAK10.45873869
110TTK0.45761431
111JAK10.45687350
112ITK0.45466868
113HCK0.45046606
114RET0.44380588
115MELK0.43994699
116ROCK20.42951765
117LMTK20.41241613
118PDK10.41097433
119EPHA30.40883437
120DMPK0.40756147
121AKT20.39914546
122YES10.39392441
123MAP3K10.38934864
124CAMKK10.38917330
125TRPM70.38915272
126JAK20.38507623
127TAOK20.38427471
128KSR10.38143856
129IRAK20.37433482
130GSK3A0.37180094
131MAP3K70.37029423
132NTRK10.36269902
133MAPKAPK20.35406242
134* SRC0.34818061
135SIK20.34439902
136SGK30.33835141

Predicted pathways (KEGG)

RankGene SetZ-score
1Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.12539578
2Bladder cancer_Homo sapiens_hsa052191.83972674
3Adherens junction_Homo sapiens_hsa045201.81060834
4Leukocyte transendothelial migration_Homo sapiens_hsa046701.71439309
5Nitrogen metabolism_Homo sapiens_hsa009101.68556711
6Proteoglycans in cancer_Homo sapiens_hsa052051.60499920
7Glycosaminoglycan degradation_Homo sapiens_hsa005311.57960216
8Focal adhesion_Homo sapiens_hsa045101.56112898
9Small cell lung cancer_Homo sapiens_hsa052221.49565908
10Galactose metabolism_Homo sapiens_hsa000521.47052603
11Chronic myeloid leukemia_Homo sapiens_hsa052201.45004614
12Fat digestion and absorption_Homo sapiens_hsa049751.43362555
13Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.41110714
14ECM-receptor interaction_Homo sapiens_hsa045121.41049046
15Leishmaniasis_Homo sapiens_hsa051401.30991028
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.30898391
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.29164813
18Amoebiasis_Homo sapiens_hsa051461.28903472
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.28591677
20Thyroid cancer_Homo sapiens_hsa052161.26985673
21Fructose and mannose metabolism_Homo sapiens_hsa000511.26859130
22Shigellosis_Homo sapiens_hsa051311.26546034
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.25881169
24B cell receptor signaling pathway_Homo sapiens_hsa046621.22859250
25AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.18958217
26Central carbon metabolism in cancer_Homo sapiens_hsa052301.17214048
27Hippo signaling pathway_Homo sapiens_hsa043901.17054406
28Toxoplasmosis_Homo sapiens_hsa051451.16925393
29Acute myeloid leukemia_Homo sapiens_hsa052211.16319458
30Apoptosis_Homo sapiens_hsa042101.15872973
31Pancreatic cancer_Homo sapiens_hsa052121.15230954
32Lysosome_Homo sapiens_hsa041421.14354137
33mTOR signaling pathway_Homo sapiens_hsa041501.13584424
34Regulation of actin cytoskeleton_Homo sapiens_hsa048101.12863919
35MicroRNAs in cancer_Homo sapiens_hsa052061.10753233
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.09916550
37Pentose and glucuronate interconversions_Homo sapiens_hsa000401.08572495
38Endometrial cancer_Homo sapiens_hsa052131.06180021
39Renin-angiotensin system_Homo sapiens_hsa046141.05898004
40Prion diseases_Homo sapiens_hsa050201.05160708
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.05131078
42Antigen processing and presentation_Homo sapiens_hsa046121.02208620
43Caffeine metabolism_Homo sapiens_hsa002321.01705822
44VEGF signaling pathway_Homo sapiens_hsa043701.00693345
45Bile secretion_Homo sapiens_hsa049760.99889339
46Viral myocarditis_Homo sapiens_hsa054160.98323048
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.97964429
48Staphylococcus aureus infection_Homo sapiens_hsa051500.97876462
49Protein digestion and absorption_Homo sapiens_hsa049740.97180008
50Other glycan degradation_Homo sapiens_hsa005110.96202997
51Osteoclast differentiation_Homo sapiens_hsa043800.94990564
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.94506200
53Complement and coagulation cascades_Homo sapiens_hsa046100.94262816
54Legionellosis_Homo sapiens_hsa051340.94066780
55Phagosome_Homo sapiens_hsa041450.92479938
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.92389166
57p53 signaling pathway_Homo sapiens_hsa041150.92112042
58Colorectal cancer_Homo sapiens_hsa052100.91448493
59Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.91024750
60TNF signaling pathway_Homo sapiens_hsa046680.87810135
61Salmonella infection_Homo sapiens_hsa051320.87376884
62Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.86727257
63Selenocompound metabolism_Homo sapiens_hsa004500.86427915
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85578472
65PPAR signaling pathway_Homo sapiens_hsa033200.84734324
66Mineral absorption_Homo sapiens_hsa049780.84534498
67Arginine biosynthesis_Homo sapiens_hsa002200.82884024
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.82832486
69Tight junction_Homo sapiens_hsa045300.82359513
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.81882642
71Insulin resistance_Homo sapiens_hsa049310.81340245
72Prolactin signaling pathway_Homo sapiens_hsa049170.80280463
73Prostate cancer_Homo sapiens_hsa052150.80015760
74Pentose phosphate pathway_Homo sapiens_hsa000300.79657165
75Chemokine signaling pathway_Homo sapiens_hsa040620.79163511
76ErbB signaling pathway_Homo sapiens_hsa040120.78230715
77Vibrio cholerae infection_Homo sapiens_hsa051100.77926252
78Insulin signaling pathway_Homo sapiens_hsa049100.76378684
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.75433411
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75165986
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.74925498
82GnRH signaling pathway_Homo sapiens_hsa049120.74304159
83Measles_Homo sapiens_hsa051620.74274938
84Non-small cell lung cancer_Homo sapiens_hsa052230.73832991
85Pertussis_Homo sapiens_hsa051330.73064175
86Rap1 signaling pathway_Homo sapiens_hsa040150.73013457
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.72917360
88Hepatitis B_Homo sapiens_hsa051610.72038263
89Notch signaling pathway_Homo sapiens_hsa043300.71631190
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.70772858
91Estrogen signaling pathway_Homo sapiens_hsa049150.69796096
92Pathways in cancer_Homo sapiens_hsa052000.68825143
93Starch and sucrose metabolism_Homo sapiens_hsa005000.67709028
94Toll-like receptor signaling pathway_Homo sapiens_hsa046200.67304135
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67294341
96Tuberculosis_Homo sapiens_hsa051520.67238600
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67162726
98Platelet activation_Homo sapiens_hsa046110.65949276
99Viral carcinogenesis_Homo sapiens_hsa052030.65687690
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65290532
101Endocytosis_Homo sapiens_hsa041440.65050862
102Hepatitis C_Homo sapiens_hsa051600.64628723
103HTLV-I infection_Homo sapiens_hsa051660.64559872
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64168033
105T cell receptor signaling pathway_Homo sapiens_hsa046600.62789484
106Tryptophan metabolism_Homo sapiens_hsa003800.62159861
107Lysine degradation_Homo sapiens_hsa003100.61623930
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61384684
109Basal cell carcinoma_Homo sapiens_hsa052170.61215374
110HIF-1 signaling pathway_Homo sapiens_hsa040660.61149531
111Choline metabolism in cancer_Homo sapiens_hsa052310.60761660
112Malaria_Homo sapiens_hsa051440.59464067
113Renal cell carcinoma_Homo sapiens_hsa052110.59287802
114Influenza A_Homo sapiens_hsa051640.58608265
115Maturity onset diabetes of the young_Homo sapiens_hsa049500.58465175
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.57665342
117Inositol phosphate metabolism_Homo sapiens_hsa005620.57029398
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55809163
119AMPK signaling pathway_Homo sapiens_hsa041520.55162928
120Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55159448
121Glioma_Homo sapiens_hsa052140.53650759
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53146835
123Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52013448
124Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51901244
125N-Glycan biosynthesis_Homo sapiens_hsa005100.48049056
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47816900
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47237459
128RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45144282

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