LARP7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which is found in the 7SK snRNP (small nuclear ribonucleoprotein). This snRNP complex inhibits a cyclin-dependent kinase, positive transcription elongation factor b, which is required for paused RNA polymerase II at a promoter to begin transcription elongation. A pseudogene of this gene is located on chromosome 3. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.33851978
2chaperone-mediated protein transport (GO:0072321)6.00205888
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.13538021
4ATP synthesis coupled proton transport (GO:0015986)5.13538021
5establishment of protein localization to mitochondrial membrane (GO:0090151)5.06026844
6regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.68626752
7regulation of mitotic spindle checkpoint (GO:1903504)4.68626752
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.62194343
9maturation of SSU-rRNA (GO:0030490)4.61372317
10respiratory electron transport chain (GO:0022904)4.40251706
11regulation of mitochondrial translation (GO:0070129)4.38927537
12termination of RNA polymerase III transcription (GO:0006386)4.35331610
13transcription elongation from RNA polymerase III promoter (GO:0006385)4.35331610
14DNA strand elongation involved in DNA replication (GO:0006271)4.30246798
15ribosomal small subunit assembly (GO:0000028)4.29555293
16electron transport chain (GO:0022900)4.27810371
17viral transcription (GO:0019083)4.21494874
18kinetochore organization (GO:0051383)4.15053982
19translational termination (GO:0006415)4.14921081
20DNA unwinding involved in DNA replication (GO:0006268)4.14738113
21mitotic metaphase plate congression (GO:0007080)4.12749342
22DNA strand elongation (GO:0022616)4.10821107
23protein neddylation (GO:0045116)4.10160095
24CENP-A containing nucleosome assembly (GO:0034080)4.10068131
25chromatin remodeling at centromere (GO:0031055)4.08977939
26exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.07529559
27ribosomal small subunit biogenesis (GO:0042274)4.04755640
28telomere maintenance via semi-conservative replication (GO:0032201)4.01066956
29DNA replication initiation (GO:0006270)4.00958228
30nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.97160668
31regulation of helicase activity (GO:0051095)3.96208309
32establishment of viral latency (GO:0019043)3.94465904
33protein localization to kinetochore (GO:0034501)3.92216933
34ribosomal large subunit biogenesis (GO:0042273)3.87359327
35formation of translation preinitiation complex (GO:0001731)3.86849129
36histone exchange (GO:0043486)3.85349712
37metaphase plate congression (GO:0051310)3.81638739
38establishment of integrated proviral latency (GO:0075713)3.81475276
39DNA replication checkpoint (GO:0000076)3.77834558
40protein localization to chromosome, centromeric region (GO:0071459)3.77788900
41DNA replication-independent nucleosome organization (GO:0034724)3.77336328
42DNA replication-independent nucleosome assembly (GO:0006336)3.77336328
43DNA replication-dependent nucleosome assembly (GO:0006335)3.76686893
44DNA replication-dependent nucleosome organization (GO:0034723)3.76686893
45telomere maintenance via recombination (GO:0000722)3.75964975
46translational elongation (GO:0006414)3.73891207
47kinetochore assembly (GO:0051382)3.73579217
48translational initiation (GO:0006413)3.68471193
49pseudouridine synthesis (GO:0001522)3.67632353
50mitotic recombination (GO:0006312)3.67433477
51histone mRNA metabolic process (GO:0008334)3.66924251
52negative regulation of DNA-dependent DNA replication (GO:2000104)3.64953315
53rRNA modification (GO:0000154)3.62756995
54nuclear pore organization (GO:0006999)3.61837854
55regulation of posttranscriptional gene silencing (GO:0060147)3.59668627
56regulation of gene silencing by miRNA (GO:0060964)3.59668627
57regulation of gene silencing by RNA (GO:0060966)3.59668627
58nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.55603266
59ribonucleoprotein complex biogenesis (GO:0022613)3.54110950
60DNA deamination (GO:0045006)3.53451910
61mitotic nuclear envelope disassembly (GO:0007077)3.49132192
62SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.47589382
63spliceosomal snRNP assembly (GO:0000387)3.46993889
64nuclear pore complex assembly (GO:0051292)3.46967122
65heterochromatin organization (GO:0070828)3.44952751
66attachment of spindle microtubules to kinetochore (GO:0008608)3.42714725
67cotranslational protein targeting to membrane (GO:0006613)3.42533548
68mitotic sister chromatid segregation (GO:0000070)3.41508130
69cilium or flagellum-dependent cell motility (GO:0001539)3.40984771
70mitochondrial respiratory chain complex assembly (GO:0033108)3.40711598
71protein complex biogenesis (GO:0070271)3.40410360
72protein targeting to ER (GO:0045047)3.38838726
73respiratory chain complex IV assembly (GO:0008535)3.37466164
74negative regulation of ligase activity (GO:0051352)3.37218422
75negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.37218422
76establishment of chromosome localization (GO:0051303)3.36926579
77regulation of nuclear cell cycle DNA replication (GO:0033262)3.36114865
78telomere maintenance via telomere lengthening (GO:0010833)3.34594941
79cellular protein complex disassembly (GO:0043624)3.34183350
80nucleobase biosynthetic process (GO:0046112)3.32390129
81regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.29617296
82mitotic chromosome condensation (GO:0007076)3.29420706
83rRNA processing (GO:0006364)3.27757091
84protein targeting to mitochondrion (GO:0006626)3.27350661
85nucleotide-excision repair, DNA gap filling (GO:0006297)3.26944395
86telomere maintenance via telomerase (GO:0007004)3.26435386
87regulation of centriole replication (GO:0046599)3.26380764
88meiotic chromosome segregation (GO:0045132)3.25867916
89viral life cycle (GO:0019058)3.25491148
90paraxial mesoderm development (GO:0048339)3.25184129
91IMP biosynthetic process (GO:0006188)3.24763067
92ribosome biogenesis (GO:0042254)3.24275521
93spliceosomal complex assembly (GO:0000245)3.23379104
94regulation of mitotic sister chromatid separation (GO:0010965)3.22831535
95regulation of mitotic sister chromatid segregation (GO:0033047)3.22831535
96regulation of sister chromatid segregation (GO:0033045)3.22831535
97negative regulation of telomerase activity (GO:0051974)3.22706904
98mitotic spindle checkpoint (GO:0071174)3.22638695
99DNA damage response, detection of DNA damage (GO:0042769)3.22428240
100establishment of protein localization to endoplasmic reticulum (GO:0072599)3.21842625
101piRNA metabolic process (GO:0034587)3.20861168
102nuclear envelope disassembly (GO:0051081)3.20444164
103membrane disassembly (GO:0030397)3.20444164
104mitotic spindle assembly checkpoint (GO:0007094)3.19858867
105DNA double-strand break processing (GO:0000729)3.19818678
106ribosome assembly (GO:0042255)3.19239440
107rRNA metabolic process (GO:0016072)3.18194657
108cytochrome complex assembly (GO:0017004)3.17855367
109negative regulation of mitosis (GO:0045839)3.15520051
110protein localization to endoplasmic reticulum (GO:0070972)3.15388116
111mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.15099816
112mitochondrial respiratory chain complex I assembly (GO:0032981)3.15099816
113NADH dehydrogenase complex assembly (GO:0010257)3.15099816
114spindle assembly checkpoint (GO:0071173)3.12386867
115binding of sperm to zona pellucida (GO:0007339)3.11158933
116protein complex disassembly (GO:0043241)3.10779294
117sister chromatid segregation (GO:0000819)3.09973895
118DNA-templated transcription, termination (GO:0006353)3.08853455
119regulation of centrosome cycle (GO:0046605)3.08558978
120mitotic G2/M transition checkpoint (GO:0044818)3.07436608
121establishment of protein localization to mitochondrion (GO:0072655)3.07429030
122water-soluble vitamin biosynthetic process (GO:0042364)3.07346674
123purine nucleobase biosynthetic process (GO:0009113)3.07298209
124regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.06801926
125rRNA methylation (GO:0031167)3.05103307
126ATP-dependent chromatin remodeling (GO:0043044)3.04661961
127viral mRNA export from host cell nucleus (GO:0046784)3.04476133
128positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.04360205
129sperm-egg recognition (GO:0035036)3.04057036
130mitotic sister chromatid cohesion (GO:0007064)3.03954917
131microtubule depolymerization (GO:0007019)3.01712404
132transcription-coupled nucleotide-excision repair (GO:0006283)3.00085864
133regulation of chromosome segregation (GO:0051983)2.99617006
134negative regulation of chromosome segregation (GO:0051985)2.99263621
135regulation of spindle organization (GO:0090224)2.99218262
136termination of RNA polymerase II transcription (GO:0006369)2.99087663
137negative regulation of mitotic sister chromatid separation (GO:2000816)2.97892351
138negative regulation of mitotic sister chromatid segregation (GO:0033048)2.97892351
139negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.97892351
140negative regulation of sister chromatid segregation (GO:0033046)2.97892351
141anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.96789865
142chromatin assembly or disassembly (GO:0006333)2.96261799
143spindle checkpoint (GO:0031577)2.95543313
144macromolecular complex disassembly (GO:0032984)2.95262305
145nuclear-transcribed mRNA catabolic process (GO:0000956)2.94933758
146regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.92580879
147regulation of histone H3-K9 methylation (GO:0051570)2.92314684
148regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.92045551
149proteasome assembly (GO:0043248)2.91320030
150RNA splicing, via transesterification reactions (GO:0000375)2.90830679
151negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.90676098
152negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.90283447
153regulation of mitotic metaphase/anaphase transition (GO:0030071)2.89472380
154male meiosis (GO:0007140)2.89403997
155mRNA splicing, via spliceosome (GO:0000398)2.89402447
156RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.89402447
157translation (GO:0006412)2.89091924

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.28450223
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.46421874
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.39461967
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.14573227
5E2F4_17652178_ChIP-ChIP_JURKAT_Human4.01016724
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.51454950
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.38753751
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.37051068
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.35842398
10MYC_19079543_ChIP-ChIP_MESCs_Mouse3.09761171
11GABP_17652178_ChIP-ChIP_JURKAT_Human3.05313072
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.91443763
13* ETS1_20019798_ChIP-Seq_JURKAT_Human2.87836771
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.84306862
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.80780065
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.75063526
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.61366916
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.58365886
19* XRN2_22483619_ChIP-Seq_HELA_Human2.45377791
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.38694856
21VDR_23849224_ChIP-Seq_CD4+_Human2.37419584
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.33669519
23AR_21909140_ChIP-Seq_LNCAP_Human2.12484669
24* FOXP3_21729870_ChIP-Seq_TREG_Human2.10876517
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.07646024
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.07208116
27DCP1A_22483619_ChIP-Seq_HELA_Human2.02985782
28POU5F1_16153702_ChIP-ChIP_HESCs_Human2.00978670
29* TTF2_22483619_ChIP-Seq_HELA_Human2.00004419
30E2F1_21310950_ChIP-Seq_MCF-7_Human1.98416300
31NANOG_16153702_ChIP-ChIP_HESCs_Human1.98230504
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.97985495
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.97539002
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.93353124
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.90650556
36E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.85369919
37GABP_19822575_ChIP-Seq_HepG2_Human1.85253349
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.85020240
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.82352951
40ELK1_19687146_ChIP-ChIP_HELA_Human1.81744151
41SOX2_16153702_ChIP-ChIP_HESCs_Human1.81690299
42KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.81407949
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77559252
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.72107501
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.71905836
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.70804691
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.70614858
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.67405060
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67145312
50EWS_26573619_Chip-Seq_HEK293_Human1.61716259
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.56395046
52* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.53800615
53NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52127736
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.52089467
55TP63_19390658_ChIP-ChIP_HaCaT_Human1.48598457
56CIITA_25753668_ChIP-Seq_RAJI_Human1.47810401
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.47680231
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43996723
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.42408015
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41583025
61NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.40121109
62FUS_26573619_Chip-Seq_HEK293_Human1.38734856
63KDM5A_27292631_Chip-Seq_BREAST_Human1.35637403
64* SRF_21415370_ChIP-Seq_HL-1_Mouse1.34489847
65* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.31162261
66* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28008178
67* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.27886745
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27531860
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26503402
70EGR1_19374776_ChIP-ChIP_THP-1_Human1.26302144
71NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.26090023
72MYC_18940864_ChIP-ChIP_HL60_Human1.25246006
73NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.22972795
74SOX2_18555785_ChIP-Seq_MESCs_Mouse1.19510078
75FLI1_27457419_Chip-Seq_LIVER_Mouse1.15272548
76ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12671079
77E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12397210
78HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.12357070
79NOTCH1_21737748_ChIP-Seq_TLL_Human1.11166690
80ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10876204
81FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09107221
82KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08531794
83MYC_22102868_ChIP-Seq_BL_Human1.08351888
84ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07814986
85SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.06937549
86SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05749241
87KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02321834
88VDR_22108803_ChIP-Seq_LS180_Human1.01572472
89PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00835884
90CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00268645
91DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98729846
92P300_19829295_ChIP-Seq_ESCs_Human0.97949195
93BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97084220
94* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.96010196
95STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95252993
96TFEB_21752829_ChIP-Seq_HELA_Human0.92291592
97PCGF2_27294783_Chip-Seq_ESCs_Mouse0.92225726
98SALL1_21062744_ChIP-ChIP_HESCs_Human0.91192178
99SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.90577072
100POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.90496653
101ZNF274_21170338_ChIP-Seq_K562_Hela0.90456698
102GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90139159
103* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.90117482
104ELK1_22589737_ChIP-Seq_MCF10A_Human0.88284248
105* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.87427050
106CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86566204
107TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.86367836
108NANOG_21062744_ChIP-ChIP_HESCs_Human0.85245000
109* SOX17_20123909_ChIP-Seq_XEN_Mouse0.78219370
110GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.77588846
111GATA1_26923725_Chip-Seq_HPCs_Mouse0.76230962
112SPI1_23547873_ChIP-Seq_NB4_Human0.75190719
113CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.74614969
114CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.74211584
115* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.73109764
116KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.72888030
117KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.72888030
118KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.72888030
119PCGF2_27294783_Chip-Seq_NPCs_Mouse0.72739616
120KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.71837886
121SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.71096671
122SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.68938206
123HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.68856166
124ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.68761665
125* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.68750556
126* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.67282585
127IGF1R_20145208_ChIP-Seq_DFB_Human0.66431806
128HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.64919731
129NFE2_27457419_Chip-Seq_LIVER_Mouse0.64782357

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.24062626
2MP0010094_abnormal_chromosome_stability4.55690532
3MP0008057_abnormal_DNA_replication4.23250180
4MP0004957_abnormal_blastocyst_morpholog4.22861157
5MP0003111_abnormal_nucleus_morphology4.13315885
6MP0008877_abnormal_DNA_methylation3.95550091
7MP0003077_abnormal_cell_cycle3.88627072
8MP0008058_abnormal_DNA_repair3.46909328
9MP0002254_reproductive_system_inflammat3.08542986
10MP0008007_abnormal_cellular_replicative2.99267367
11MP0008932_abnormal_embryonic_tissue2.75395568
12MP0005410_abnormal_fertilization2.65127425
13MP0001188_hyperpigmentation2.54158768
14MP0001730_embryonic_growth_arrest2.25680203
15MP0003123_paternal_imprinting2.25087795
16MP0003786_premature_aging2.11762306
17MP0001929_abnormal_gametogenesis2.03182845
18MP0000350_abnormal_cell_proliferation2.01066088
19MP0002210_abnormal_sex_determination2.00835834
20MP0003890_abnormal_embryonic-extraembry1.77215655
21MP0002277_abnormal_respiratory_mucosa1.70995127
22MP0001672_abnormal_embryogenesis/_devel1.70338238
23MP0005380_embryogenesis_phenotype1.70338238
24MP0001697_abnormal_embryo_size1.69948879
25MP0006072_abnormal_retinal_apoptosis1.69533442
26MP0001145_abnormal_male_reproductive1.69531188
27MP0002396_abnormal_hematopoietic_system1.69199435
28MP0001529_abnormal_vocalization1.68375416
29MP0003698_abnormal_male_reproductive1.61521701
30MP0001293_anophthalmia1.57566035
31MP0003984_embryonic_growth_retardation1.52321580
32MP0006292_abnormal_olfactory_placode1.51803198
33MP0010030_abnormal_orbit_morphology1.51157654
34MP0002085_abnormal_embryonic_tissue1.49494825
35MP0004808_abnormal_hematopoietic_stem1.48304702
36MP0002088_abnormal_embryonic_growth/wei1.48176654
37MP0000653_abnormal_sex_gland1.46680041
38MP0002080_prenatal_lethality1.46579415
39MP0009697_abnormal_copulation1.46550979
40MP0002084_abnormal_developmental_patter1.44810023
41MP0003315_abnormal_perineum_morphology1.42677254
42MP0000313_abnormal_cell_death1.42327621
43MP0002653_abnormal_ependyma_morphology1.41932700
44MP0004133_heterotaxia1.38728209
45MP0003121_genomic_imprinting1.35718060
46MP0001485_abnormal_pinna_reflex1.35154003
47MP0000579_abnormal_nail_morphology1.34553062
48MP0003186_abnormal_redox_activity1.32742790
49MP0002160_abnormal_reproductive_system1.28422226
50MP0004197_abnormal_fetal_growth/weight/1.28389702
51MP0010352_gastrointestinal_tract_polyps1.27783022
52MP0010307_abnormal_tumor_latency1.27058575
53MP0001984_abnormal_olfaction1.26654718
54MP0003718_maternal_effect1.26405859
55MP0000490_abnormal_crypts_of1.25983229
56MP0003567_abnormal_fetal_cardiomyocyte1.24363379
57MP0002086_abnormal_extraembryonic_tissu1.20405296
58MP0002019_abnormal_tumor_incidence1.17787736
59MP0002233_abnormal_nose_morphology1.16730221
60MP0009379_abnormal_foot_pigmentation1.16345880
61MP0002796_impaired_skin_barrier1.15642640
62MP0002736_abnormal_nociception_after1.11731122
63MP0002102_abnormal_ear_morphology1.07966590
64MP0000703_abnormal_thymus_morphology1.06556157
65MP0005394_taste/olfaction_phenotype1.06198251
66MP0005499_abnormal_olfactory_system1.06198251
67MP0006036_abnormal_mitochondrial_physio1.05659085
68MP0003119_abnormal_digestive_system1.05419247
69MP0003763_abnormal_thymus_physiology1.03557831
70MP0002161_abnormal_fertility/fecundity1.03002786
71MP0000537_abnormal_urethra_morphology1.02583953
72MP0001177_atelectasis1.01092024
73MP0003787_abnormal_imprinting0.98428861
74MP0000631_abnormal_neuroendocrine_gland0.97342283
75MP0003938_abnormal_ear_development0.96000137
76MP0001545_abnormal_hematopoietic_system0.95469882
77MP0005397_hematopoietic_system_phenotyp0.95469882
78MP0005389_reproductive_system_phenotype0.94637311
79MP0003937_abnormal_limbs/digits/tail_de0.93785537
80MP0002938_white_spotting0.92822301
81MP0009333_abnormal_splenocyte_physiolog0.92025369
82MP0005084_abnormal_gallbladder_morpholo0.87791678
83MP0000049_abnormal_middle_ear0.84655301
84MP0003806_abnormal_nucleotide_metabolis0.84399929
85MP0001119_abnormal_female_reproductive0.83627130
86MP0003011_delayed_dark_adaptation0.83320477
87MP0009053_abnormal_anal_canal0.83188417
88MP0008995_early_reproductive_senescence0.81411811
89MP0002398_abnormal_bone_marrow0.81010477
90MP0009672_abnormal_birth_weight0.78961102
91MP0004215_abnormal_myocardial_fiber0.78758726
92MP0002722_abnormal_immune_system0.78042946
93MP0001286_abnormal_eye_development0.77635285
94MP0002090_abnormal_vision0.76928472
95MP0000358_abnormal_cell_content/0.75999850
96MP0002132_abnormal_respiratory_system0.75942195
97MP0008789_abnormal_olfactory_epithelium0.75773761
98MP0000432_abnormal_head_morphology0.74141283
99MP0000689_abnormal_spleen_morphology0.73857165
100MP0003755_abnormal_palate_morphology0.73856881
101MP0001727_abnormal_embryo_implantation0.72968184
102MP0000762_abnormal_tongue_morphology0.72388665
103MP0002092_abnormal_eye_morphology0.71439644
104MP0002111_abnormal_tail_morphology0.71008078
105MP0003878_abnormal_ear_physiology0.70851255
106MP0005377_hearing/vestibular/ear_phenot0.70851255
107MP0003137_abnormal_impulse_conducting0.70501817
108MP0002282_abnormal_trachea_morphology0.67722450
109MP0003941_abnormal_skin_development0.67516772
110MP0005395_other_phenotype0.67311747
111MP0005391_vision/eye_phenotype0.65766713
112MP0009703_decreased_birth_body0.63521692
113MP0003136_yellow_coat_color0.63485969
114MP0001299_abnormal_eye_distance/0.63373830
115MP0003122_maternal_imprinting0.63030099
116MP0002234_abnormal_pharynx_morphology0.63021066
117MP0000428_abnormal_craniofacial_morphol0.62399167
118MP0003861_abnormal_nervous_system0.61245208
119MP0002751_abnormal_autonomic_nervous0.60775817
120MP0005076_abnormal_cell_differentiation0.60684011
121MP0002114_abnormal_axial_skeleton0.59389044
122MP0002429_abnormal_blood_cell0.59140395
123MP0004019_abnormal_vitamin_homeostasis0.58521511
124MP0003195_calcinosis0.58379024
125MP0001919_abnormal_reproductive_system0.58224780
126MP0005384_cellular_phenotype0.56755066
127MP0002163_abnormal_gland_morphology0.56574698
128MP0009278_abnormal_bone_marrow0.56453229
129MP0002697_abnormal_eye_size0.56181066
130MP0005253_abnormal_eye_physiology0.55342536
131MP0005174_abnormal_tail_pigmentation0.54565000
132MP0003935_abnormal_craniofacial_develop0.54040753
133MP0004142_abnormal_muscle_tone0.53541763
134MP0000858_altered_metastatic_potential0.53303612
135MP0006035_abnormal_mitochondrial_morpho0.52763215
136MP0000750_abnormal_muscle_regeneration0.52397111
137MP0002932_abnormal_joint_morphology0.51389772
138MP0000566_synostosis0.50892516

Predicted human phenotypes

RankGene SetZ-score
1Septo-optic dysplasia (HP:0100842)5.01839843
2Reticulocytopenia (HP:0001896)4.46417101
3Acute necrotizing encephalopathy (HP:0006965)4.40873967
4Abnormality of cells of the erythroid lineage (HP:0012130)4.38208384
5Increased hepatocellular lipid droplets (HP:0006565)4.35870001
6Birth length less than 3rd percentile (HP:0003561)4.34193616
7Abnormal number of erythroid precursors (HP:0012131)4.06597984
8Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.89377703
9Lipid accumulation in hepatocytes (HP:0006561)3.88961435
10Acute encephalopathy (HP:0006846)3.85598274
11Abnormal mitochondria in muscle tissue (HP:0008316)3.74421453
12Mitochondrial inheritance (HP:0001427)3.56893414
13Progressive macrocephaly (HP:0004481)3.56702464
14Dynein arm defect of respiratory motile cilia (HP:0012255)3.52481830
15Absent/shortened dynein arms (HP:0200106)3.52481830
16Abnormality of the labia minora (HP:0012880)3.44742424
17Chromsome breakage (HP:0040012)3.36141845
18Breast hypoplasia (HP:0003187)3.32315191
19Colon cancer (HP:0003003)3.23409414
20Degeneration of anterior horn cells (HP:0002398)3.22963908
21Abnormality of the anterior horn cell (HP:0006802)3.22963908
22Supernumerary spleens (HP:0009799)3.18751616
23Increased CSF lactate (HP:0002490)3.18720122
24Abnormal respiratory epithelium morphology (HP:0012253)3.14606823
25Abnormal respiratory motile cilium morphology (HP:0005938)3.14606823
26Absent septum pellucidum (HP:0001331)3.12497445
27Renal Fanconi syndrome (HP:0001994)3.08300198
28Macrocytic anemia (HP:0001972)3.06945747
29Oral leukoplakia (HP:0002745)3.05367157
30Congenital, generalized hypertrichosis (HP:0004540)3.03712618
31Selective tooth agenesis (HP:0001592)3.03554823
32Chromosomal breakage induced by crosslinking agents (HP:0003221)3.00774185
33Patellar aplasia (HP:0006443)3.00285879
34Abnormality of homocysteine metabolism (HP:0010919)2.96087814
35Homocystinuria (HP:0002156)2.96087814
36Methylmalonic acidemia (HP:0002912)2.95093566
37Cerebral edema (HP:0002181)2.94212116
38Pallor (HP:0000980)2.93595830
39Maternal diabetes (HP:0009800)2.91371564
40Bilateral microphthalmos (HP:0007633)2.91333123
41Meckel diverticulum (HP:0002245)2.90739620
42Hypoglycemic seizures (HP:0002173)2.89646367
43Absent thumb (HP:0009777)2.87225309
44Impulsivity (HP:0100710)2.86576268
45Abnormality of the preputium (HP:0100587)2.86308519
46Abnormality of the septum pellucidum (HP:0007375)2.85972715
4711 pairs of ribs (HP:0000878)2.84963570
48Aplasia/Hypoplasia of the patella (HP:0006498)2.81416332
49Abnormal lung lobation (HP:0002101)2.79842695
50Abnormality of the ileum (HP:0001549)2.79126871
51Abnormality of chromosome stability (HP:0003220)2.78430282
52Carpal bone hypoplasia (HP:0001498)2.77814605
53Aplastic anemia (HP:0001915)2.77716987
54Megaloblastic anemia (HP:0001889)2.77665955
55Multiple enchondromatosis (HP:0005701)2.77544157
56Pancreatic islet-cell hyperplasia (HP:0004510)2.74941569
57Abnormality of methionine metabolism (HP:0010901)2.67747578
58Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.67544212
59Medulloblastoma (HP:0002885)2.65141672
60Hyperinsulinemic hypoglycemia (HP:0000825)2.64358479
61Exertional dyspnea (HP:0002875)2.63781097
62Hepatocellular necrosis (HP:0001404)2.63656337
63Chronic bronchitis (HP:0004469)2.62977842
64Absent radius (HP:0003974)2.57083723
65Methylmalonic aciduria (HP:0012120)2.56205740
66Abnormal respiratory motile cilium physiology (HP:0012261)2.53891090
67Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.52974623
68Aplasia/Hypoplasia of the uvula (HP:0010293)2.51775197
69Ectopic kidney (HP:0000086)2.50318894
70Myelodysplasia (HP:0002863)2.49290334
71Abnormal number of incisors (HP:0011064)2.45041503
72Optic nerve hypoplasia (HP:0000609)2.43850584
73Duodenal stenosis (HP:0100867)2.43655717
74Small intestinal stenosis (HP:0012848)2.43655717
75Respiratory difficulties (HP:0002880)2.41546620
76Absent forearm bone (HP:0003953)2.41066867
77Aplasia involving forearm bones (HP:0009822)2.41066867
78Abnormality of the lacrimal duct (HP:0011481)2.34986548
79Rhinitis (HP:0012384)2.33940913
80Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.33892086
81Decreased activity of mitochondrial respiratory chain (HP:0008972)2.33892086
82Sloping forehead (HP:0000340)2.33372368
83Leukodystrophy (HP:0002415)2.32774991
84Increased intramyocellular lipid droplets (HP:0012240)2.31124593
85Rough bone trabeculation (HP:0100670)2.28971182
86Horseshoe kidney (HP:0000085)2.27784294
87Nephroblastoma (Wilms tumor) (HP:0002667)2.26891670
88Facial cleft (HP:0002006)2.24618462
89Abnormality of abdominal situs (HP:0011620)2.24614149
90Abdominal situs inversus (HP:0003363)2.24614149
91Abnormality of serum amino acid levels (HP:0003112)2.24087658
92Triphalangeal thumb (HP:0001199)2.23560907
93Abnormality of aspartate family amino acid metabolism (HP:0010899)2.22976537
94Pendular nystagmus (HP:0012043)2.21069716
95Cleft eyelid (HP:0000625)2.20923491
96Hyperglycinemia (HP:0002154)2.18860102
97Hypoplasia of the radius (HP:0002984)2.18420800
98Asplenia (HP:0001746)2.16201229
99Hepatic necrosis (HP:0002605)2.14458822
100Esophageal atresia (HP:0002032)2.14299617
101Hypoglycemic coma (HP:0001325)2.12821313
102Premature graying of hair (HP:0002216)2.12733970
103Abnormal spermatogenesis (HP:0008669)2.12526497
104Aplasia/Hypoplasia of the sacrum (HP:0008517)2.12492840
105Symptomatic seizures (HP:0011145)2.11760166
106Hypoplasia of the capital femoral epiphysis (HP:0003090)2.11702025
107Neoplasm of the pancreas (HP:0002894)2.10615269
108Ependymoma (HP:0002888)2.10472367
109Cerebral hypomyelination (HP:0006808)2.10255333
110Atresia of the external auditory canal (HP:0000413)2.09560588
111Embryonal renal neoplasm (HP:0011794)2.09009269
112Abnormal ciliary motility (HP:0012262)2.08632585
113Abnormality of the nasolacrimal system (HP:0000614)2.06663452
114Volvulus (HP:0002580)2.06656443
115Abnormality of renal resorption (HP:0011038)2.06567349
116Cellular immunodeficiency (HP:0005374)2.06015929
117Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.05489372
118Increased nuchal translucency (HP:0010880)2.04771122
119Breast aplasia (HP:0100783)2.04687732
120Agnosia (HP:0010524)2.04507693
121Abnormality of the duodenum (HP:0002246)2.03856713
122Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.01863612
123Rhabdomyosarcoma (HP:0002859)2.00950492
124Anophthalmia (HP:0000528)2.00539488
125Tracheoesophageal fistula (HP:0002575)1.99791020
126Bone marrow hypocellularity (HP:0005528)1.99629989
127Trismus (HP:0000211)1.98591717
128Nasolacrimal duct obstruction (HP:0000579)1.97646075
129Aplasia/Hypoplasia of the spleen (HP:0010451)1.97211020
130Exercise intolerance (HP:0003546)1.96675888
131Duplicated collecting system (HP:0000081)1.95393635
132Bifid tongue (HP:0010297)1.94104254
133Nephronophthisis (HP:0000090)1.94037599
134Sparse eyelashes (HP:0000653)1.91783960
135Hyperglycinuria (HP:0003108)1.91780585
136Respiratory failure (HP:0002878)1.90461932
137Short thumb (HP:0009778)1.89890285
138Rib fusion (HP:0000902)1.89472816
139Pancreatic fibrosis (HP:0100732)1.88637481
140Pancytopenia (HP:0001876)1.88307983
141Aplasia/Hypoplasia of the sternum (HP:0006714)1.88120515
142Increased serum lactate (HP:0002151)1.87039006
143Aplasia/Hypoplasia of the breasts (HP:0010311)1.86987665
144Lactic acidosis (HP:0003128)1.86626197
145Proximal placement of thumb (HP:0009623)1.86249104
146Overlapping toe (HP:0001845)1.85374961
147Abnormality of placental membranes (HP:0011409)1.85298158
148Amniotic constriction ring (HP:0009775)1.85298158
149Optic disc pallor (HP:0000543)1.84961827
150Bronchitis (HP:0012387)1.84351132
151Missing ribs (HP:0000921)1.84321070
152Secondary amenorrhea (HP:0000869)1.82998707
153Microvesicular hepatic steatosis (HP:0001414)1.80421575
154Squamous cell carcinoma (HP:0002860)1.79691203
155Increased muscle lipid content (HP:0009058)1.79154684
156Aplasia/hypoplasia of the humerus (HP:0006507)1.77331837
157Optic nerve coloboma (HP:0000588)1.77103763
158Exercise-induced muscle cramps (HP:0003710)1.76942444
159Atrophy/Degeneration involving motor neurons (HP:0007373)1.75872358
160Supernumerary bones of the axial skeleton (HP:0009144)1.75756469
161Microretrognathia (HP:0000308)1.74436938
162Premature ovarian failure (HP:0008209)1.73943172
163Deviation of the thumb (HP:0009603)1.73048217
164Nasal polyposis (HP:0100582)1.71478740
165Neoplasm of the colon (HP:0100273)1.69478381
166Muscle fiber atrophy (HP:0100295)1.69217531
167Bronchiectasis (HP:0002110)1.67552196
168Gonadotropin excess (HP:0000837)1.67510799

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.77587584
2BUB14.55041128
3VRK24.40234231
4WEE14.36771652
5TNIK3.53417009
6EIF2AK12.90637279
7SRPK12.90482984
8PLK42.89250729
9NEK22.87579388
10TAF12.68879498
11TTK2.40464038
12PDK42.28326137
13PDK32.28326137
14NME22.23323300
15ACVR1B2.12176495
16BRSK22.12120194
17PLK12.05494482
18MKNK12.04274457
19VRK12.00045652
20TSSK61.85545361
21WNK31.82174339
22STK161.81815618
23PASK1.79046571
24ATR1.77040997
25PNCK1.76246947
26AURKB1.75455107
27NUAK11.73396996
28TLK11.68495085
29EIF2AK31.66724078
30CDK71.65133473
31PLK31.63320946
32DYRK31.61065739
33TESK21.60142776
34MKNK21.58218310
35TESK11.53227940
36CDK121.50009958
37CHEK21.46272882
38CHEK11.35048730
39RPS6KA41.34836335
40PDK21.32872416
41CCNB11.30458895
42RPS6KB21.28234207
43AURKA1.26876877
44CDK41.20547010
45NEK11.17334538
46STK101.16369649
47BRSK11.14939486
48TGFBR11.14634971
49CDK191.11836636
50ATM1.02386511
51MAP3K80.97963167
52ERBB40.96136654
53PAK40.95604092
54PBK0.91382855
55CSNK1G10.88264718
56CDK80.86341153
57BRD40.85716001
58STK40.84697638
59CDK20.82909008
60MAP3K100.82699203
61CSNK2A20.81583101
62KDR0.78645046
63TRIM280.77480281
64MELK0.76488666
65CSNK2A10.76445434
66OXSR10.76040058
67ZAK0.74806038
68GRK10.74238051
69PAK10.68129430
70EIF2AK20.67651417
71CDK10.66497313
72FGFR10.65265330
73STK240.63734937
74CASK0.61723516
75RPS6KA50.61237033
76MAP3K90.60947865
77NME10.60936014
78BRAF0.59750394
79CDK30.59158986
80PIM10.58128311
81STK38L0.56668110
82CDK60.55932751
83TIE10.55257807
84CSNK1G20.54350281
85STK30.54101643
86PRKCG0.51300890
87LATS20.49484229
88EPHA20.49183049
89EEF2K0.47769180
90DMPK0.44829410
91LRRK20.40409885
92CSNK1E0.39961452
93BTK0.39361338
94PRKDC0.37172651
95CSNK1G30.36844113
96LATS10.36479496
97TEC0.36432989
98PLK20.35255776
99MAP4K10.35044470
100PRKCI0.32981794
101PIM20.32340655
102CSNK1A10.32244666
103CLK10.31494576
104MAP2K30.31422258
105MAP3K120.29799940
106MST40.28789220
107PINK10.28655431
108ADRBK20.28382587
109SCYL20.27847963
110ILK0.27699159
111MAP3K40.27068422
112NLK0.25902951
113MATK0.25705007
114DYRK20.24260798
115ZAP700.23437503
116FLT30.22555859
117PRKACB0.21978990
118ALK0.21730811
119YES10.20425730
120MTOR0.20073563
121BMPR1B0.19879595
122MAPK140.19646981
123GRK60.19243964
124AKT20.17593620
125UHMK10.17285337
126OBSCN0.17269789
127PRKG20.17029502
128MARK30.16932584
129BCKDK0.16282919
130MAP2K70.15002579
131BMX0.14648486
132CSNK1D0.14611858
133AKT10.14532335
134ICK0.14480538
135PAK20.14059160
136CDK90.13108469
137GSK3B0.12714603

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.70954660
2Mismatch repair_Homo sapiens_hsa034304.14687713
3Ribosome_Homo sapiens_hsa030104.12380713
4Spliceosome_Homo sapiens_hsa030403.68267540
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.61181669
6Proteasome_Homo sapiens_hsa030503.49599225
7RNA polymerase_Homo sapiens_hsa030203.39511336
8RNA transport_Homo sapiens_hsa030133.24260500
9Homologous recombination_Homo sapiens_hsa034403.20761106
10Nucleotide excision repair_Homo sapiens_hsa034202.89079929
11Base excision repair_Homo sapiens_hsa034102.82315780
12Cell cycle_Homo sapiens_hsa041102.67043891
13Fanconi anemia pathway_Homo sapiens_hsa034602.60821393
14Pyrimidine metabolism_Homo sapiens_hsa002402.53571460
15Basal transcription factors_Homo sapiens_hsa030222.40778190
16Non-homologous end-joining_Homo sapiens_hsa034502.29396087
17RNA degradation_Homo sapiens_hsa030182.11237291
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.10070684
19One carbon pool by folate_Homo sapiens_hsa006702.04129882
20mRNA surveillance pathway_Homo sapiens_hsa030152.00214650
21p53 signaling pathway_Homo sapiens_hsa041151.44564264
22Purine metabolism_Homo sapiens_hsa002301.44457220
23Vitamin digestion and absorption_Homo sapiens_hsa049771.38719127
24Huntingtons disease_Homo sapiens_hsa050161.28978636
25Epstein-Barr virus infection_Homo sapiens_hsa051691.21415766
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.20617844
27Propanoate metabolism_Homo sapiens_hsa006401.17886802
28Oocyte meiosis_Homo sapiens_hsa041141.17527089
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.15653680
30Protein export_Homo sapiens_hsa030601.12180360
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08844297
32Systemic lupus erythematosus_Homo sapiens_hsa053221.06254157
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.04303711
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04097751
35Steroid biosynthesis_Homo sapiens_hsa001001.03417979
36Parkinsons disease_Homo sapiens_hsa050120.95789933
37Antigen processing and presentation_Homo sapiens_hsa046120.93767832
38Herpes simplex infection_Homo sapiens_hsa051680.88285685
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81970356
40Oxidative phosphorylation_Homo sapiens_hsa001900.80594901
41Cysteine and methionine metabolism_Homo sapiens_hsa002700.79007548
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76826662
43Viral carcinogenesis_Homo sapiens_hsa052030.76143120
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75390642
45HTLV-I infection_Homo sapiens_hsa051660.72189801
46Pentose phosphate pathway_Homo sapiens_hsa000300.66962024
47Selenocompound metabolism_Homo sapiens_hsa004500.66824336
48Vitamin B6 metabolism_Homo sapiens_hsa007500.62626276
49Basal cell carcinoma_Homo sapiens_hsa052170.62608216
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57962909
51Fatty acid elongation_Homo sapiens_hsa000620.57413124
52Primary immunodeficiency_Homo sapiens_hsa053400.55517110
53Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51620749
54Phototransduction_Homo sapiens_hsa047440.51329009
55Thyroid cancer_Homo sapiens_hsa052160.50747934
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50648369
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50114939
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49391417
59Hedgehog signaling pathway_Homo sapiens_hsa043400.47987786
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47789630
61MicroRNAs in cancer_Homo sapiens_hsa052060.47345035
62Retinol metabolism_Homo sapiens_hsa008300.46552916
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46527393
64Biosynthesis of amino acids_Homo sapiens_hsa012300.45677242
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44796497
66Glutathione metabolism_Homo sapiens_hsa004800.44500501
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.42904155
68TGF-beta signaling pathway_Homo sapiens_hsa043500.42870526
69Caffeine metabolism_Homo sapiens_hsa002320.42767013
70Fatty acid degradation_Homo sapiens_hsa000710.41893246
71Chemical carcinogenesis_Homo sapiens_hsa052040.41222078
72Tryptophan metabolism_Homo sapiens_hsa003800.40674818
73Alzheimers disease_Homo sapiens_hsa050100.40568349
74Legionellosis_Homo sapiens_hsa051340.40540177
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39899009
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39517082
77Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39111453
78Hippo signaling pathway_Homo sapiens_hsa043900.39087030
79Folate biosynthesis_Homo sapiens_hsa007900.38026112
80Small cell lung cancer_Homo sapiens_hsa052220.37535001
81Alcoholism_Homo sapiens_hsa050340.37389959
82Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35716300
83beta-Alanine metabolism_Homo sapiens_hsa004100.35565081
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33930844
85Peroxisome_Homo sapiens_hsa041460.31122981
86Wnt signaling pathway_Homo sapiens_hsa043100.29555421
87N-Glycan biosynthesis_Homo sapiens_hsa005100.29174587
88Nicotine addiction_Homo sapiens_hsa050330.28866552
89Notch signaling pathway_Homo sapiens_hsa043300.28801431
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.28206047
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.28039622
92Measles_Homo sapiens_hsa051620.27316621
93Carbon metabolism_Homo sapiens_hsa012000.26956690
94Butanoate metabolism_Homo sapiens_hsa006500.26237361
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25269784
96Pathways in cancer_Homo sapiens_hsa052000.24328643
97Sulfur relay system_Homo sapiens_hsa041220.24206056
98Fatty acid metabolism_Homo sapiens_hsa012120.23796604
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.23324130
100Arachidonic acid metabolism_Homo sapiens_hsa005900.22802378
101Metabolic pathways_Homo sapiens_hsa011000.22298069
102Pyruvate metabolism_Homo sapiens_hsa006200.22259403
103Linoleic acid metabolism_Homo sapiens_hsa005910.21654031
104Colorectal cancer_Homo sapiens_hsa052100.21328602
105NF-kappa B signaling pathway_Homo sapiens_hsa040640.20314327
106Fructose and mannose metabolism_Homo sapiens_hsa000510.20208245
107Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.19197348
108Shigellosis_Homo sapiens_hsa051310.18805476
109Cardiac muscle contraction_Homo sapiens_hsa042600.18624968
110Hepatitis B_Homo sapiens_hsa051610.18407874
111Arginine and proline metabolism_Homo sapiens_hsa003300.17675144
112Taste transduction_Homo sapiens_hsa047420.17636135
113Asthma_Homo sapiens_hsa053100.17532503
114Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17373558
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.17261509
116NOD-like receptor signaling pathway_Homo sapiens_hsa046210.17140509
117Apoptosis_Homo sapiens_hsa042100.17119355
118HIF-1 signaling pathway_Homo sapiens_hsa040660.17049078
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.16848879
120Hematopoietic cell lineage_Homo sapiens_hsa046400.16837950
121Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.16644884
122Fat digestion and absorption_Homo sapiens_hsa049750.15870817
123Maturity onset diabetes of the young_Homo sapiens_hsa049500.15467068
124Cyanoamino acid metabolism_Homo sapiens_hsa004600.15395389
125Adherens junction_Homo sapiens_hsa045200.13959711
126Olfactory transduction_Homo sapiens_hsa047400.13316115
127Influenza A_Homo sapiens_hsa051640.13017660
128Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.12450101
129Intestinal immune network for IgA production_Homo sapiens_hsa046720.11846169
130Allograft rejection_Homo sapiens_hsa053300.11131729
131Prostate cancer_Homo sapiens_hsa052150.10368975
132Nitrogen metabolism_Homo sapiens_hsa009100.09749061
133Autoimmune thyroid disease_Homo sapiens_hsa053200.08547857
134Melanoma_Homo sapiens_hsa052180.07863695
135Central carbon metabolism in cancer_Homo sapiens_hsa052300.07697136
136Viral myocarditis_Homo sapiens_hsa054160.06972905
137Tight junction_Homo sapiens_hsa045300.05167532
138alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.04817302

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