LARP4B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of an evolutionarily conserved protein family implicated in RNA metabolism and translation. Members of this family are characterized by the presence of an La motif, which is often located adjacent to one or more RNA recognition motifs (RRM). Together, the two motifs constitute the functional region of the protein and enable its interaction with the RNA substrate. This protein family is divided into five sub-families: the genuine La proteins and four La-related protein (LARP) sub-families. The protein encoded by this gene belongs to LARP sub-family 4. It is a cytoplasmic protein that may play a stimulatory role in translation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hydrogen peroxide biosynthetic process (GO:0050665)4.54283460
2nuclear pore complex assembly (GO:0051292)4.41937138
3superoxide anion generation (GO:0042554)4.41337254
4reactive oxygen species biosynthetic process (GO:1903409)4.04034151
5neutrophil activation involved in immune response (GO:0002283)3.90793929
6positive regulation by symbiont of host defense response (GO:0052509)3.89401483
7modulation by symbiont of host defense response (GO:0052031)3.89401483
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.89401483
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.89401483
10positive regulation by organism of defense response of other organism involved in symbiotic interact3.89401483
11modulation by symbiont of host immune response (GO:0052553)3.89401483
12lactate metabolic process (GO:0006089)3.78678376
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.77185252
14keratinocyte development (GO:0003334)3.76224422
15response to peptidoglycan (GO:0032494)3.74642185
16positive regulation of macroautophagy (GO:0016239)3.71073762
17natural killer cell mediated cytotoxicity (GO:0042267)3.70326302
18natural killer cell mediated immunity (GO:0002228)3.70326302
19negative regulation of execution phase of apoptosis (GO:1900118)3.56957765
20nuclear pore organization (GO:0006999)3.47266519
21positive regulation of interferon-alpha production (GO:0032727)3.45341705
22positive regulation of p38MAPK cascade (GO:1900745)3.44348633
23regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.41581686
24pore complex assembly (GO:0046931)3.40163136
25mitochondrial DNA replication (GO:0006264)3.34076515
26hepatocyte apoptotic process (GO:0097284)3.33255777
27respiratory burst (GO:0045730)3.31707816
28regulation of interferon-alpha production (GO:0032647)3.31146436
29cytoplasmic mRNA processing body assembly (GO:0033962)3.24902836
30iron ion import (GO:0097286)3.19800322
31cellular extravasation (GO:0045123)3.19363847
32protein K11-linked deubiquitination (GO:0035871)3.18602622
33regulation of interleukin-12 biosynthetic process (GO:0045075)3.18261943
34cellular response to zinc ion (GO:0071294)3.17622420
35sequestering of metal ion (GO:0051238)3.16905873
36positive regulation of chemokine biosynthetic process (GO:0045080)3.16530908
37UDP-N-acetylglucosamine metabolic process (GO:0006047)3.15622916
38positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.15394527
39granulocyte activation (GO:0036230)3.14619113
40Arp2/3 complex-mediated actin nucleation (GO:0034314)3.12565641
41ribosome assembly (GO:0042255)3.10284428
42positive regulation of histone H3-K4 methylation (GO:0051571)3.09581260
43positive regulation of chromosome segregation (GO:0051984)3.07598045
44protein K6-linked ubiquitination (GO:0085020)3.07384687
45regulation of DNA endoreduplication (GO:0032875)3.06232362
46negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.06228296
47positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.03177880
48ER overload response (GO:0006983)3.03169221
49sister chromatid cohesion (GO:0007062)3.01514204
50neutrophil activation (GO:0042119)3.01057989
51COPII vesicle coating (GO:0048208)2.98748602
52positive regulation of glycoprotein biosynthetic process (GO:0010560)2.91424817
53positive regulation of interferon-beta production (GO:0032728)2.90486894
54production of molecular mediator involved in inflammatory response (GO:0002532)2.88527681
55regulation of Rac protein signal transduction (GO:0035020)2.88383877
56positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.86891526
57positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.86891526
58positive regulation of mitotic sister chromatid separation (GO:1901970)2.86891526
59regulation of mitotic spindle organization (GO:0060236)2.86153281
60regulation of centriole replication (GO:0046599)2.85644869
61leukocyte mediated cytotoxicity (GO:0001909)2.84999482
62intestinal epithelial cell development (GO:0060576)2.84168539
63positive regulation of protein autophosphorylation (GO:0031954)2.84078351
64positive regulation of mRNA catabolic process (GO:0061014)2.82267969
65neural tube formation (GO:0001841)2.80217878
66negative regulation of mRNA metabolic process (GO:1903312)2.79298631
67positive regulation of interleukin-12 production (GO:0032735)2.79090723
68positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.77702941
69response to pheromone (GO:0019236)2.73818176
70regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.73057749
71single strand break repair (GO:0000012)2.72937393
72positive regulation of response to nutrient levels (GO:0032109)2.71327010
73positive regulation of response to extracellular stimulus (GO:0032106)2.71327010
74replication fork processing (GO:0031297)2.71309405
75regulation of vitamin D biosynthetic process (GO:0060556)2.70022847
76macrophage activation involved in immune response (GO:0002281)2.67984116
77cytokine secretion (GO:0050663)2.66980238
78positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.65059341
79neutrophil mediated immunity (GO:0002446)2.64835183
80early endosome to late endosome transport (GO:0045022)2.64019803
81positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.63600482
82positive regulation of protein import into nucleus, translocation (GO:0033160)2.63206679
83response to host immune response (GO:0052572)2.62609446
84response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.62609446
85actin nucleation (GO:0045010)2.62054578
86Golgi to endosome transport (GO:0006895)2.62028457
87prostate gland growth (GO:0060736)2.60594870
88positive regulation of glycoprotein metabolic process (GO:1903020)2.60435230
89mitotic sister chromatid cohesion (GO:0007064)2.59869832
90lipopolysaccharide-mediated signaling pathway (GO:0031663)2.59392042
91leukocyte aggregation (GO:0070486)2.58746592
92T-helper 1 type immune response (GO:0042088)2.57623170
93fibroblast migration (GO:0010761)2.56851662
94double-strand break repair via nonhomologous end joining (GO:0006303)2.56720283
95non-recombinational repair (GO:0000726)2.56720283
96regulation of chemokine biosynthetic process (GO:0045073)2.56367575
97regulation of spindle organization (GO:0090224)2.56111297
98desmosome organization (GO:0002934)2.56089875
99regulation of interferon-beta biosynthetic process (GO:0045357)2.54786223
100response to muramyl dipeptide (GO:0032495)2.54633915
101cellular response to glucose starvation (GO:0042149)2.54584645
102embryonic process involved in female pregnancy (GO:0060136)2.54304423
103inositol phosphate catabolic process (GO:0071545)2.54276623
104histone H2A acetylation (GO:0043968)2.51939287
105regulation of mRNA 3-end processing (GO:0031440)2.51395630
106positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.51216570
107corticosteroid receptor signaling pathway (GO:0031958)2.51024623
108response to hydroperoxide (GO:0033194)2.50616046
109regulation of histone H3-K27 methylation (GO:0061085)2.48825288
110cellular response to ethanol (GO:0071361)2.47204946
111positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.47173961
112regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.47173961
113cell wall macromolecule catabolic process (GO:0016998)2.46999907
114Rap protein signal transduction (GO:0032486)2.46974357
115positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.46709711
116mitochondrial DNA metabolic process (GO:0032042)2.45752404
117regulation of fibroblast apoptotic process (GO:2000269)2.45442026
118T-helper cell differentiation (GO:0042093)2.45164136
119CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.45164136
120regulation of type B pancreatic cell apoptotic process (GO:2000674)2.45109586
121positive regulation of DNA-templated transcription, initiation (GO:2000144)2.45107649
122mRNA cleavage (GO:0006379)2.43384344
123mitotic nuclear envelope disassembly (GO:0007077)2.43351818
124modulation of growth of symbiont involved in interaction with host (GO:0044144)2.43106037
125regulation of growth of symbiont in host (GO:0044126)2.43106037
126negative regulation of growth of symbiont in host (GO:0044130)2.43106037
127negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.43106037
128response to fungus (GO:0009620)2.42985568
129endosome to pigment granule transport (GO:0043485)2.42826278
130endosome to melanosome transport (GO:0035646)2.42826278
131somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.41919425
132somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.41919425
133isotype switching (GO:0045190)2.41919425
134positive regulation of cellular amide metabolic process (GO:0034250)2.41624558
135negative regulation of DNA-dependent DNA replication (GO:2000104)2.41441328
136growth hormone receptor signaling pathway (GO:0060396)2.40888718
137regulation of B cell apoptotic process (GO:0002902)2.40353013
138regulation of mRNA catabolic process (GO:0061013)2.40206378
139histone mRNA catabolic process (GO:0071044)2.39817901
140polyol catabolic process (GO:0046174)2.39743108
141cell killing (GO:0001906)2.39707195
142regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.38954864
143positive regulation of nitric oxide biosynthetic process (GO:0045429)2.38787846
144ovulation from ovarian follicle (GO:0001542)2.38632081
145JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.38079863
146positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.37780056
147response to X-ray (GO:0010165)2.37131195
148immunoglobulin mediated immune response (GO:0016064)2.37105935
149regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.36851926
150myeloid dendritic cell activation (GO:0001773)2.36716808
151transcytosis (GO:0045056)2.36542948
152folic acid-containing compound biosynthetic process (GO:0009396)2.35648119
153regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.35626187
154response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.35107962
155response to host (GO:0075136)2.35107962
156response to host defenses (GO:0052200)2.35107962
157regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.34960706
158positive regulation of gamma-delta T cell activation (GO:0046645)2.34276588
159nucleotide-sugar biosynthetic process (GO:0009226)2.34089416
160DNA replication checkpoint (GO:0000076)2.33791815
161regulation of protein autophosphorylation (GO:0031952)2.33563590
162inositol phosphate dephosphorylation (GO:0046855)2.33291193
163phosphorylated carbohydrate dephosphorylation (GO:0046838)2.33291193
164double-strand break repair via homologous recombination (GO:0000724)2.33188939
165regulation of interferon-beta production (GO:0032648)2.33037287
166regulation of translational termination (GO:0006449)2.32370123
167protein prenylation (GO:0018342)2.31990544
168prenylation (GO:0097354)2.31990544
169myeloid dendritic cell differentiation (GO:0043011)2.31758117
170DNA-dependent DNA replication (GO:0006261)2.31436016
171positive regulation of response to biotic stimulus (GO:0002833)2.31331422
172regulation of vitamin metabolic process (GO:0030656)2.30687305
173T cell activation involved in immune response (GO:0002286)2.30204930
174B cell mediated immunity (GO:0019724)2.29895030
175DNA double-strand break processing (GO:0000729)2.29885796
176negative regulation of lipid storage (GO:0010888)2.29810398
177regulation of histone H3-K4 methylation (GO:0051569)2.29371685
178necroptotic process (GO:0070266)2.28881743
179recombinational repair (GO:0000725)2.28745348
180phosphatidylinositol dephosphorylation (GO:0046856)2.27011418
181double-strand break repair (GO:0006302)2.26537360
182negative regulation of histone acetylation (GO:0035067)2.26497325
183positive regulation of mRNA 3-end processing (GO:0031442)2.26481393
184membrane disassembly (GO:0030397)2.26051432
185nuclear envelope disassembly (GO:0051081)2.26051432
186positive regulation of autophagy (GO:0010508)2.25042798
187negative regulation of mRNA processing (GO:0050686)2.24841896

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.79916799
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.02766474
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.98294926
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.79829926
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.10901580
6Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.05280820
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.90965581
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.66091730
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.59935728
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.56063038
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.55993965
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.53825835
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.44820820
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.44594561
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.32096011
16TP63_17297297_ChIP-ChIP_HaCaT_Human2.25625046
17GATA1_22025678_ChIP-Seq_K562_Human2.19080862
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.19071284
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.16125898
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.14378659
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.06793445
22SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.04339433
23SALL1_21062744_ChIP-ChIP_HESCs_Human2.01265674
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.99131361
25ESR1_20079471_ChIP-ChIP_T-47D_Human1.95936075
26RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.94055768
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.90281634
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.86702998
29* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.84877399
30STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.83650238
31MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.81429060
32E2F4_17652178_ChIP-ChIP_JURKAT_Human1.74306960
33FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.64977580
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60551137
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58618293
36AR_21909140_ChIP-Seq_LNCAP_Human1.57606432
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.57291670
38BRD4_27068464_Chip-Seq_AML-cells_Mouse1.55241134
39SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.53658572
40SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.53658572
41ELK1_19687146_ChIP-ChIP_HELA_Human1.51221928
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.49858397
43STAT4_19710469_ChIP-ChIP_TH1__Mouse1.49786642
44PU_27001747_Chip-Seq_BMDM_Mouse1.48914873
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.48587539
46BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.48270990
47SALL4_18804426_ChIP-ChIP_XEN_Mouse1.48214908
48EGR1_23403033_ChIP-Seq_LIVER_Mouse1.47007560
49VDR_24787735_ChIP-Seq_THP-1_Human1.44621047
50E2F1_21310950_ChIP-Seq_MCF-7_Human1.39519164
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37085841
52E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.36725414
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.29953789
54ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25943576
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23937570
56AHR_22903824_ChIP-Seq_MCF-7_Human1.23486891
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23088754
58DCP1A_22483619_ChIP-Seq_HELA_Human1.22368068
59FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.22008165
60RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21546229
61GATA6_25053715_ChIP-Seq_YYC3_Human1.21086463
62* KDM5A_27292631_Chip-Seq_BREAST_Human1.19451653
63SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.18569918
64FLI1_27457419_Chip-Seq_LIVER_Mouse1.17944257
65CDX2_22108803_ChIP-Seq_LS180_Human1.17940318
66NRF2_20460467_ChIP-Seq_MEFs_Mouse1.17888274
67NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.17888274
68ELF5_23300383_ChIP-Seq_T47D_Human1.16859298
69VDR_23849224_ChIP-Seq_CD4+_Human1.15456339
70MYB_26560356_Chip-Seq_TH1_Human1.12970797
71GATA3_24758297_ChIP-Seq_MCF-7_Human1.12898806
72FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.12439864
73PPAR_26484153_Chip-Seq_NCI-H1993_Human1.12266035
74MYB_26560356_Chip-Seq_TH2_Human1.12032843
75CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11429508
76TP63_19390658_ChIP-ChIP_HaCaT_Human1.11272875
77AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.11098238
78FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10654192
79CJUN_26792858_Chip-Seq_BT549_Human1.10626854
80ESR1_21235772_ChIP-Seq_MCF-7_Human1.10466842
81* LXR_22158963_ChIP-Seq_LIVER_Mouse1.10300364
82SRF_21415370_ChIP-Seq_HL-1_Mouse1.08906372
83SPI1_23547873_ChIP-Seq_NB4_Human1.08142591
84YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07795280
85PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07117732
86SOX2_20726797_ChIP-Seq_SW620_Human1.06871742
87GABP_17652178_ChIP-ChIP_JURKAT_Human1.06187208
88FOXM1_26456572_ChIP-Seq_MCF-7_Human1.05794819
89FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.05532144
90PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05221158
91FOXO3_23340844_ChIP-Seq_DLD1_Human1.05193606
92FOXP3_21729870_ChIP-Seq_TREG_Human1.05016410
93GATA4_25053715_ChIP-Seq_YYC3_Human1.04213062
94RUNX_20019798_ChIP-Seq_JUKART_Human1.04169898
95FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.04061829
96EST1_17652178_ChIP-ChIP_JURKAT_Human1.03704133
97ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.03622321
98CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02520990
99CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.02237227
100BRD4_25478319_ChIP-Seq_HGPS_Human1.02094473
101GATA3_27048872_Chip-Seq_THYMUS_Human1.01808652
102ER_23166858_ChIP-Seq_MCF-7_Human1.01434831
103TP53_16413492_ChIP-PET_HCT116_Human0.99985540
104RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.98535191
105GATA2_21666600_ChIP-Seq_HMVEC_Human0.96382100
106GATA4_21415370_ChIP-Seq_HL-1_Mouse0.96310024
107HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.95247353
108FUS_26573619_Chip-Seq_HEK293_Human0.95067643
109ARNT_22903824_ChIP-Seq_MCF-7_Human0.94892055
110ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94674335
111PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.94106550
112TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93287502
113MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.92879820
114AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89700942
115TCF4_18268006_ChIP-ChIP_LS174T_Human0.89195764
116PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89017986
117PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88986562
118CDX2_19796622_ChIP-Seq_MESCs_Mouse0.87861755
119SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.87127020
120CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.86852966
121RXR_22158963_ChIP-Seq_LIVER_Mouse0.86562336
122PPARA_22158963_ChIP-Seq_LIVER_Mouse0.86371468
123TFEB_21752829_ChIP-Seq_HELA_Human0.86199383
124WT1_19549856_ChIP-ChIP_CCG9911_Human0.85885207
125SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.84487526
126GATA3_26560356_Chip-Seq_TH2_Human0.84254805
127* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84084747
128* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.83962449
129* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.83932672
130FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.83227738
131HOXB4_20404135_ChIP-ChIP_EML_Mouse0.82310301
132SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.81267129
133EWS_26573619_Chip-Seq_HEK293_Human0.78724223
134ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.78231780
135PIAS1_25552417_ChIP-Seq_VCAP_Human0.76907820
136CHD1_26751641_Chip-Seq_LNCaP_Human0.76878776

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.03281799
2MP0001835_abnormal_antigen_presentation2.84613321
3MP0003950_abnormal_plasma_membrane2.81343657
4MP0002877_abnormal_melanocyte_morpholog2.72939076
5MP0009780_abnormal_chondrocyte_physiolo2.65871697
6MP0010352_gastrointestinal_tract_polyps2.55931538
7MP0003303_peritoneal_inflammation2.54523217
8MP0003436_decreased_susceptibility_to2.50981232
9MP0000569_abnormal_digit_pigmentation2.32308627
10MP0009785_altered_susceptibility_to2.29950923
11MP0002148_abnormal_hypersensitivity_rea2.28684975
12MP0010678_abnormal_skin_adnexa2.18694936
13MP0003786_premature_aging2.13712066
14MP0005076_abnormal_cell_differentiation2.07918165
15MP0000427_abnormal_hair_cycle2.05731729
16MP0008058_abnormal_DNA_repair1.95587090
17MP0003252_abnormal_bile_duct1.95320845
18MP0002419_abnormal_innate_immunity1.92208335
19MP0002006_tumorigenesis1.91297852
20MP0002254_reproductive_system_inflammat1.87618009
21MP0010307_abnormal_tumor_latency1.87037008
22MP0001661_extended_life_span1.84747174
23MP0003300_gastrointestinal_ulcer1.82642229
24MP0005000_abnormal_immune_tolerance1.79792138
25MP0002396_abnormal_hematopoietic_system1.78652349
26MP0005451_abnormal_body_composition1.76997769
27MP0003566_abnormal_cell_adhesion1.72858520
28MP0003705_abnormal_hypodermis_morpholog1.68766176
29MP0003724_increased_susceptibility_to1.68300609
30MP0001790_abnormal_immune_system1.67089338
31MP0005387_immune_system_phenotype1.67089338
32MP0005025_abnormal_response_to1.66981516
33MP0008877_abnormal_DNA_methylation1.66257517
34MP0004947_skin_inflammation1.63946560
35MP0002166_altered_tumor_susceptibility1.61027070
36MP0000015_abnormal_ear_pigmentation1.59877985
37MP0003172_abnormal_lysosome_physiology1.59740096
38MP0002452_abnormal_antigen_presenting1.58242770
39MP0009764_decreased_sensitivity_to1.56745565
40MP0002138_abnormal_hepatobiliary_system1.55094399
41MP0008007_abnormal_cellular_replicative1.52303682
42MP0001800_abnormal_humoral_immune1.48620814
43MP0004510_myositis1.47893205
44MP0002139_abnormal_hepatobiliary_system1.46993878
45MP0002837_dystrophic_cardiac_calcinosis1.46291805
46MP0003448_altered_tumor_morphology1.44920590
47MP0004782_abnormal_surfactant_physiolog1.44123690
48MP0005671_abnormal_response_to1.43706397
49MP0010234_abnormal_vibrissa_follicle1.43229112
50MP0002405_respiratory_system_inflammati1.36151065
51MP0002723_abnormal_immune_serum1.36044978
52MP0008057_abnormal_DNA_replication1.34027254
53MP0003828_pulmonary_edema1.29686971
54MP0004264_abnormal_extraembryonic_tissu1.28430680
55MP0010155_abnormal_intestine_physiology1.28223811
56MP0006082_CNS_inflammation1.27960017
57MP0001819_abnormal_immune_cell1.27861366
58MP0005464_abnormal_platelet_physiology1.26823326
59MP0001845_abnormal_inflammatory_respons1.26677150
60MP0001533_abnormal_skeleton_physiology1.26440895
61MP0003693_abnormal_embryo_hatching1.26102936
62MP0008995_early_reproductive_senescence1.24960528
63MP0002420_abnormal_adaptive_immunity1.24706889
64MP0000383_abnormal_hair_follicle1.20437895
65MP0004808_abnormal_hematopoietic_stem1.19453983
66MP0002168_other_aberrant_phenotype1.18408387
67MP0003656_abnormal_erythrocyte_physiolo1.18309071
68MP0005360_urolithiasis1.18198425
69MP0003186_abnormal_redox_activity1.17764695
70MP0004957_abnormal_blastocyst_morpholog1.17474768
71MP0001873_stomach_inflammation1.17379431
72MP0005174_abnormal_tail_pigmentation1.17127924
73MP0005310_abnormal_salivary_gland1.15735444
74MP0002693_abnormal_pancreas_physiology1.15489518
75MP0005083_abnormal_biliary_tract1.14236938
76MP0002928_abnormal_bile_duct1.12924621
77MP0006036_abnormal_mitochondrial_physio1.12566485
78MP0005220_abnormal_exocrine_pancreas1.12485427
79MP0000858_altered_metastatic_potential1.11731006
80MP0005085_abnormal_gallbladder_physiolo1.11136054
81MP0003941_abnormal_skin_development1.10089313
82MP0004381_abnormal_hair_follicle1.09453995
83MP0003183_abnormal_peptide_metabolism1.08010090
84MP0001853_heart_inflammation1.05917156
85MP0003943_abnormal_hepatobiliary_system1.05755922
86MP0003763_abnormal_thymus_physiology1.05360571
87MP0001545_abnormal_hematopoietic_system1.04879937
88MP0005397_hematopoietic_system_phenotyp1.04879937
89MP0002009_preneoplasia1.04591866
90MP0003045_fibrosis1.04322456
91MP0003453_abnormal_keratinocyte_physiol1.03843027
92MP0000377_abnormal_hair_follicle1.03656585
93MP0000685_abnormal_immune_system1.03493387
94MP0002398_abnormal_bone_marrow1.01679108
95MP0005408_hypopigmentation1.00986846
96MP0003806_abnormal_nucleotide_metabolis0.99429472
97MP0005367_renal/urinary_system_phenotyp0.99249985
98MP0000516_abnormal_urinary_system0.99249985
99MP0000358_abnormal_cell_content/0.99127938
100MP0000372_irregular_coat_pigmentation0.98151649
101MP0009697_abnormal_copulation0.97222117
102MP0005647_abnormal_sex_gland0.96210052
103MP0002269_muscular_atrophy0.95161870
104MP0005075_abnormal_melanosome_morpholog0.94494111
105MP0008469_abnormal_protein_level0.93926566
106MP0004233_abnormal_muscle_weight0.91460934
107MP0000716_abnormal_immune_system0.90753570
108MP0009053_abnormal_anal_canal0.90153982
109MP0000627_abnormal_mammary_gland0.89909603
110MP0002998_abnormal_bone_remodeling0.89797647
111MP0004185_abnormal_adipocyte_glucose0.89715416
112MP0009763_increased_sensitivity_to0.89524995
113MP0001944_abnormal_pancreas_morphology0.87807730
114MP0003890_abnormal_embryonic-extraembry0.87647671
115MP0006035_abnormal_mitochondrial_morpho0.87488757
116MP0003646_muscle_fatigue0.87470304
117MP0000490_abnormal_crypts_of0.87220031
118MP0002163_abnormal_gland_morphology0.87061954
119MP0003091_abnormal_cell_migration0.86489640
120MP0005379_endocrine/exocrine_gland_phen0.85918386
121MP0001730_embryonic_growth_arrest0.84530718
122MP0001216_abnormal_epidermal_layer0.84361992
123MP0000371_diluted_coat_color0.84067554
124MP0001881_abnormal_mammary_gland0.83741136
125MP0001697_abnormal_embryo_size0.83400867
126MP0010094_abnormal_chromosome_stability0.82578853
127MP0001915_intracranial_hemorrhage0.82437193
128MP0003077_abnormal_cell_cycle0.81793897
129MP0002332_abnormal_exercise_endurance0.81782803
130MP0002088_abnormal_embryonic_growth/wei0.81263471
131MP0005395_other_phenotype0.80415536
132MP0002019_abnormal_tumor_incidence0.80378258
133MP0003984_embryonic_growth_retardation0.79328933
134MP0001727_abnormal_embryo_implantation0.78641984
135MP0000613_abnormal_salivary_gland0.78218201
136MP0002086_abnormal_extraembryonic_tissu0.77363368
137MP0005380_embryogenesis_phenotype0.77138142
138MP0002722_abnormal_immune_system0.76975903
139MP0001919_abnormal_reproductive_system0.76871462
140MP0000343_altered_response_to0.76535737
141MP0006054_spinal_hemorrhage0.76334476
142MP0005166_decreased_susceptibility_to0.75587884
143MP0000609_abnormal_liver_physiology0.74679780
144MP0001191_abnormal_skin_condition0.73672758
145MP0000350_abnormal_cell_proliferation0.73391912
146MP0003787_abnormal_imprinting0.73296468
147MP0003111_abnormal_nucleus_morphology0.73021982
148MP0000003_abnormal_adipose_tissue0.72593247
149MP0001672_abnormal_embryogenesis/_devel0.71681571
150MP0002970_abnormal_white_adipose0.70499293
151MP0005266_abnormal_metabolism0.70488835
152MP0004043_abnormal_pH_regulation0.69425093
153MP0005384_cellular_phenotype0.69053400
154MP0005330_cardiomyopathy0.69039885
155MP0005409_darkened_coat_color0.67828291
156MP0008961_abnormal_basal_metabolism0.66094055
157MP0002060_abnormal_skin_morphology0.65252515
158MP0005621_abnormal_cell_physiology0.64645239
159MP0009115_abnormal_fat_cell0.64470889

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.31194000
2Recurrent gram-negative bacterial infections (HP:0005420)4.75093900
3Recurrent abscess formation (HP:0002722)4.53863286
4Recurrent bacterial skin infections (HP:0005406)4.51149753
5Autoimmune thrombocytopenia (HP:0001973)4.16025733
6Hamartoma of the eye (HP:0010568)3.93562076
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.72706887
8Aqueductal stenosis (HP:0002410)3.51765965
9Chromsome breakage (HP:0040012)3.41904662
10Abnormality of the nasal septum (HP:0000419)3.34632958
11Macroorchidism (HP:0000053)3.18055930
12Breast carcinoma (HP:0003002)3.16577578
13Albinism (HP:0001022)3.16418617
14Hyperglycemia (HP:0003074)3.14156104
15Conjunctival hamartoma (HP:0100780)3.12941851
16Abnormality of endocrine pancreas physiology (HP:0012093)3.12451619
17Abnormality of the pancreatic islet cells (HP:0006476)3.12451619
18Hyperinsulinemic hypoglycemia (HP:0000825)3.06998285
19Neoplasm of the adrenal gland (HP:0100631)2.99358534
20Ketoacidosis (HP:0001993)2.97337177
21Myocardial infarction (HP:0001658)2.96843652
22Periodontitis (HP:0000704)2.93271550
23Lip pit (HP:0100267)2.93258280
24Gingivitis (HP:0000230)2.92555385
25Recurrent fungal infections (HP:0002841)2.89389205
26Mediastinal lymphadenopathy (HP:0100721)2.81302535
27Glucose intolerance (HP:0000833)2.77694848
28Syringomyelia (HP:0003396)2.76388274
29Spinal cord lesions (HP:0100561)2.76388274
30Enlarged penis (HP:0000040)2.68862915
31Abnormality of the fingertips (HP:0001211)2.66242291
32Sparse lateral eyebrow (HP:0005338)2.65757827
33Hypothermia (HP:0002045)2.65226601
34Abnormality of chromosome stability (HP:0003220)2.64075650
35Pancreatic islet-cell hyperplasia (HP:0004510)2.61583507
36Retrobulbar optic neuritis (HP:0100654)2.61342050
37Optic neuritis (HP:0100653)2.61342050
38Abnormality of the astrocytes (HP:0100707)2.58647697
39Astrocytoma (HP:0009592)2.58647697
40Abnormality of the parathyroid morphology (HP:0011766)2.58615456
41Gastrointestinal infarctions (HP:0005244)2.58325703
42Papillary thyroid carcinoma (HP:0002895)2.56531229
43Abnormal glucose tolerance (HP:0001952)2.55302454
44Absent frontal sinuses (HP:0002688)2.54698776
45Osteomyelitis (HP:0002754)2.53141026
46Chronic obstructive pulmonary disease (HP:0006510)2.52598207
47Obstructive lung disease (HP:0006536)2.52598207
48Recurrent viral infections (HP:0004429)2.52129379
49Testicular neoplasm (HP:0010788)2.50963568
50Arterial thrombosis (HP:0004420)2.49720914
51Prostate neoplasm (HP:0100787)2.48857629
52Abnormality of macrophages (HP:0004311)2.48701703
53Cortical dysplasia (HP:0002539)2.47922875
54Abnormal pancreas size (HP:0012094)2.41836189
55Submucous cleft hard palate (HP:0000176)2.41475485
56Glioma (HP:0009733)2.40700457
57Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.40665279
58Abnormal hair whorl (HP:0010721)2.40221002
59Ependymoma (HP:0002888)2.39812126
60Thick nail (HP:0001805)2.38836515
61Osteolytic defects of the hand bones (HP:0009699)2.37937400
62Osteolytic defects of the phalanges of the hand (HP:0009771)2.37937400
63Neoplasm of the tracheobronchial system (HP:0100552)2.36732436
64Hyporeflexia of lower limbs (HP:0002600)2.36572168
65Subacute progressive viral hepatitis (HP:0006572)2.36032595
66Deep philtrum (HP:0002002)2.35869250
67Volvulus (HP:0002580)2.35729500
68Sensory axonal neuropathy (HP:0003390)2.32149540
69Curly hair (HP:0002212)2.31892298
70Chronic diarrhea (HP:0002028)2.31570640
71Recurrent skin infections (HP:0001581)2.30680493
72Abnormal platelet volume (HP:0011876)2.29255493
73Increased mean platelet volume (HP:0011877)2.26966651
74Orchitis (HP:0100796)2.26821102
75Alveolar cell carcinoma (HP:0006519)2.25147067
76Rhabdomyosarcoma (HP:0002859)2.25056650
77Asymmetry of the thorax (HP:0001555)2.24794471
78Thyroid carcinoma (HP:0002890)2.24003648
79Autoimmune hemolytic anemia (HP:0001890)2.22388443
80Abnormality of the preputium (HP:0100587)2.21981815
81Intestinal atresia (HP:0011100)2.19119817
82Progressive inability to walk (HP:0002505)2.19100948
83Vasculitis (HP:0002633)2.18965483
84Acanthocytosis (HP:0001927)2.18797593
85Pustule (HP:0200039)2.18194436
86Neoplasm of the adrenal cortex (HP:0100641)2.17516393
87Tetraparesis (HP:0002273)2.17025448
88Esophageal varix (HP:0002040)2.16805933
89Disinhibition (HP:0000734)2.15701346
90Interstitial pulmonary disease (HP:0006530)2.14301545
91Cellulitis (HP:0100658)2.13978315
92Right ventricular cardiomyopathy (HP:0011663)2.13712261
93Transitional cell carcinoma of the bladder (HP:0006740)2.13570164
94Abnormality of T cell number (HP:0011839)2.12650201
95Myositis (HP:0100614)2.12261356
96Acute myeloid leukemia (HP:0004808)2.11776642
97Thyroiditis (HP:0100646)2.11635508
98Prominent metopic ridge (HP:0005487)2.11520411
99Abnormality of the anterior horn cell (HP:0006802)2.11180115
100Degeneration of anterior horn cells (HP:0002398)2.11180115
101Increased CSF protein (HP:0002922)2.10143038
102Hypoglycemic seizures (HP:0002173)2.08064627
103Symptomatic seizures (HP:0011145)2.07443666
104Hematochezia (HP:0002573)2.07045134
105Barrel-shaped chest (HP:0001552)2.06767396
106Hypochromic anemia (HP:0001931)2.06179090
107Stomatitis (HP:0010280)2.06178300
108Bladder carcinoma (HP:0002862)2.05839690
109Bladder neoplasm (HP:0009725)2.05839690
110Anorexia (HP:0002039)2.05513243
111Meningioma (HP:0002858)2.04313006
112Late onset (HP:0003584)2.03373683
113Biliary tract neoplasm (HP:0100574)2.03304278
114Keratoconjunctivitis sicca (HP:0001097)2.01133078
115Upper motor neuron abnormality (HP:0002127)1.98687220
116Cutaneous melanoma (HP:0012056)1.98363477
117Prominent nose (HP:0000448)1.98320782
118Popliteal pterygium (HP:0009756)1.98099770
119Disproportionate short-trunk short stature (HP:0003521)1.97837044
120Joint hemorrhage (HP:0005261)1.93206404
121Calf muscle hypertrophy (HP:0008981)1.91483113
122Adenoma sebaceum (HP:0009720)1.91333272
123Angiofibromas (HP:0010615)1.91333272
124Mucosal telangiectasiae (HP:0100579)1.91164750
125Eosinophilia (HP:0001880)1.90557459
126Abnormal biliary tract morphology (HP:0012440)1.89212837
127Hypochromic microcytic anemia (HP:0004840)1.88617607
128Tongue fasciculations (HP:0001308)1.88258313
129Clubbing of toes (HP:0100760)1.87849076
130Abnormality of proline metabolism (HP:0010907)1.87240830
131Hydroxyprolinuria (HP:0003080)1.87240830
132Abnormality of glutamine family amino acid metabolism (HP:0010902)1.86813622
133Abnormality of the common coagulation pathway (HP:0010990)1.86241090
134Pulmonary infiltrates (HP:0002113)1.86053730
135Fair hair (HP:0002286)1.85251308
136Hypoglycemic coma (HP:0001325)1.84818188
137Leukocytosis (HP:0001974)1.84379258
138Subaortic stenosis (HP:0001682)1.84156053
139Abnormality of the left ventricular outflow tract (HP:0011103)1.84156053
140Abnormality of the prostate (HP:0008775)1.83988294
141Vacuolated lymphocytes (HP:0001922)1.83612235
142Progressive external ophthalmoplegia (HP:0000590)1.83155371
143Dyschromatopsia (HP:0007641)1.83087772
144Hypoplasia of the odontoid process (HP:0003311)1.83086643
145Ovarian neoplasm (HP:0100615)1.83033350
146Cafe-au-lait spot (HP:0000957)1.82388565
147Long clavicles (HP:0000890)1.82201523
148Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.81518849
149Cone-rod dystrophy (HP:0000548)1.81489017
150Urethral obstruction (HP:0000796)1.81409602
151Menorrhagia (HP:0000132)1.80924361
152Poikilocytosis (HP:0004447)1.80602083
153T lymphocytopenia (HP:0005403)1.80574992
154Abnormal foot bone ossification (HP:0010675)1.80293939
155Posterior subcapsular cataract (HP:0007787)1.80240636
156Uterine neoplasm (HP:0010784)1.80018253
157Aplasia/Hypoplasia of the uvula (HP:0010293)1.79789642
158Micronodular cirrhosis (HP:0001413)1.79172977
159Pheochromocytoma (HP:0002666)1.78996187
160Abnormality of chromosome segregation (HP:0002916)1.78078749
161Leiomyosarcoma (HP:0100243)1.77405390
162Uterine leiomyosarcoma (HP:0002891)1.77405390
163Gingival bleeding (HP:0000225)1.77207510
164Renal cortical cysts (HP:0000803)1.75281101
165Anal stenosis (HP:0002025)1.74191558
166Abnormality of vitamin B metabolism (HP:0004340)1.73774862
167Short chin (HP:0000331)1.70871810
168Insulin-resistant diabetes mellitus (HP:0000831)1.69925449
169Orthostatic hypotension (HP:0001278)1.69131293
170High pitched voice (HP:0001620)1.68796024
171Delayed puberty (HP:0000823)1.68056805
172Muscle fibrillation (HP:0010546)1.64368709
173Abnormality of the metopic suture (HP:0005556)1.64224991
174Muscle hypertrophy of the lower extremities (HP:0008968)1.62893919
175Squamous cell carcinoma (HP:0002860)1.62764602
176Nephroblastoma (Wilms tumor) (HP:0002667)1.62224688
177Double outlet right ventricle (HP:0001719)1.58444866
178Congenital malformation of the right heart (HP:0011723)1.58444866
179Downturned corners of mouth (HP:0002714)1.57354441
180Meckel diverticulum (HP:0002245)1.54911496
181Sloping forehead (HP:0000340)1.54340423

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM284.64737146
2MAP3K144.32491170
3FRK3.25621321
4ZAK3.17744768
5IRAK42.54785798
6IRAK32.48959727
7FGFR22.44843750
8FER2.16782149
9STK242.11422228
10NUAK12.10241765
11BMPR1B2.06048324
12MKNK22.03046434
13LATS11.99565768
14AKT31.95894269
15SIK31.91470970
16STK31.91060110
17JAK31.90831665
18ERBB31.89418794
19STK41.89293276
20MST41.87799797
21NEK91.85512217
22TAOK31.76029992
23RIPK41.66641204
24CDK121.57521553
25EIF2AK21.53544648
26TBK11.52398064
27CDK61.51051606
28STK38L1.50065547
29CHUK1.48517122
30SGK21.48380416
31STK391.48022462
32TAF11.48015904
33PBK1.47540194
34NEK11.43499389
35ERBB41.43427153
36MAP3K31.40597691
37STK101.39199829
38NLK1.37949821
39FGFR31.33885228
40PIM11.32094119
41MARK31.27082880
42MST1R1.25475724
43SGK31.23917570
44DMPK1.23646236
45IKBKB1.22190430
46PTK61.21121915
47PDK21.20540514
48EIF2AK11.18217139
49JAK11.14586730
50PRKCI1.13906997
51CAMK1G1.12618140
52TRPM71.12553368
53TTN1.10582905
54TYK21.08915398
55TXK1.07280126
56MAP4K11.07078775
57CDC71.06899112
58PLK31.06242948
59TSSK61.06099815
60MAP3K51.05653253
61PAK31.04827368
62BRD41.01943070
63MAPKAPK30.95165346
64EPHA20.94741454
65IRAK10.93802153
66MAP3K120.91247268
67BMPR20.91232553
68PLK20.90844447
69RPS6KA40.89242164
70OXSR10.87780544
71FGFR10.86934859
72TEC0.86583715
73BUB10.85830491
74TTK0.81835190
75IKBKE0.81464957
76MAP2K30.80629231
77EEF2K0.80375158
78SRPK10.80086567
79CAMK1D0.78204254
80JAK20.77612927
81RPS6KB20.77440849
82TNIK0.77257692
83MELK0.72786452
84RPS6KA20.72618136
85RPS6KB10.71709234
86PLK40.71022456
87ATM0.69810385
88MAP3K20.69599777
89CDK40.69580987
90PKN20.68892087
91CSK0.66975853
92MAP2K60.66232997
93PIK3CA0.66056404
94EIF2AK30.65956774
95BRSK10.65599244
96RPS6KL10.65585774
97RPS6KC10.65585774
98PRKCH0.64648404
99SMG10.64201024
100WEE10.61175528
101PHKG20.58758175
102PHKG10.58758175
103PIM20.57613551
104ICK0.56828701
105YES10.56545371
106CLK10.56493021
107MKNK10.55907912
108RPS6KA60.55813265
109MAP2K10.55412034
110SYK0.54938633
111PRKD30.54254535
112SCYL20.53139171
113ABL10.52607514
114PRKCQ0.51569748
115MAPKAPK20.51500213
116SGK10.51289169
117LCK0.50826454
118PNCK0.50736649
119EPHA30.50564854
120ALK0.47686332
121EGFR0.47467630
122ABL20.47252745
123AURKB0.47019077
124OBSCN0.47017415
125BCR0.45774740
126PRKCD0.44890463
127MAPK110.44742767
128CHEK10.44708458
129ITK0.44201954
130ATR0.43692841
131LMTK20.43661658
132PRKAA10.43390012
133CDK80.40783789
134GRK10.40360616
135CHEK20.40169033
136ACVR1B0.39667248
137PTK20.39263917
138CDK90.38618794
139BMX0.37964630
140TGFBR20.37767822
141AKT10.37540487
142BRSK20.37365528
143FGFR40.37133199
144HCK0.35679901
145HIPK20.35258733
146PRKAA20.35236717
147MAP3K110.35054451
148TGFBR10.31722632
149KSR10.29491395
150PLK10.24814322
151MTOR0.24162615
152PTK2B0.23594585
153AKT20.23571885
154FLT30.22259072

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.32912347
2Leishmaniasis_Homo sapiens_hsa051402.94408982
3Allograft rejection_Homo sapiens_hsa053302.77456801
4Vitamin B6 metabolism_Homo sapiens_hsa007502.75586782
5Proteasome_Homo sapiens_hsa030502.72307947
6NOD-like receptor signaling pathway_Homo sapiens_hsa046212.39029976
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.38513269
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.38407233
9Type I diabetes mellitus_Homo sapiens_hsa049402.31858207
10Protein export_Homo sapiens_hsa030602.27839066
11Homologous recombination_Homo sapiens_hsa034402.26079354
12Legionellosis_Homo sapiens_hsa051342.19554215
13Toll-like receptor signaling pathway_Homo sapiens_hsa046202.10576115
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.06553337
15Staphylococcus aureus infection_Homo sapiens_hsa051501.98347862
16Measles_Homo sapiens_hsa051621.86619965
17One carbon pool by folate_Homo sapiens_hsa006701.81182688
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.80953618
19Fanconi anemia pathway_Homo sapiens_hsa034601.78909032
20Sulfur metabolism_Homo sapiens_hsa009201.78155724
21Osteoclast differentiation_Homo sapiens_hsa043801.72366050
22Influenza A_Homo sapiens_hsa051641.71411682
23TNF signaling pathway_Homo sapiens_hsa046681.70935711
24Tuberculosis_Homo sapiens_hsa051521.69922008
25Viral myocarditis_Homo sapiens_hsa054161.65007409
26Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.63827601
27Basal transcription factors_Homo sapiens_hsa030221.62262904
28Propanoate metabolism_Homo sapiens_hsa006401.60294411
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.60179081
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.59699797
31Pertussis_Homo sapiens_hsa051331.56688628
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.52489341
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.49118188
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.46725492
35Toxoplasmosis_Homo sapiens_hsa051451.46467631
36Sphingolipid metabolism_Homo sapiens_hsa006001.44002718
37Malaria_Homo sapiens_hsa051441.42948002
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.40760048
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.39443404
40Herpes simplex infection_Homo sapiens_hsa051681.39186657
41Antigen processing and presentation_Homo sapiens_hsa046121.38716037
42Apoptosis_Homo sapiens_hsa042101.36187482
43Salmonella infection_Homo sapiens_hsa051321.34360987
44Other glycan degradation_Homo sapiens_hsa005111.32526737
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.31285369
46Hematopoietic cell lineage_Homo sapiens_hsa046401.30539712
47RNA transport_Homo sapiens_hsa030131.29188751
48RNA degradation_Homo sapiens_hsa030181.28755702
49Mismatch repair_Homo sapiens_hsa034301.26609540
50Asthma_Homo sapiens_hsa053101.25939389
51Adherens junction_Homo sapiens_hsa045201.24805350
52Jak-STAT signaling pathway_Homo sapiens_hsa046301.24395576
53Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.21874110
54Inositol phosphate metabolism_Homo sapiens_hsa005621.21043943
55Prostate cancer_Homo sapiens_hsa052151.20673897
56Autoimmune thyroid disease_Homo sapiens_hsa053201.20576550
57Selenocompound metabolism_Homo sapiens_hsa004501.15067908
58Hepatitis C_Homo sapiens_hsa051601.13651134
59Hepatitis B_Homo sapiens_hsa051611.13494991
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.12472873
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.09353210
62Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.07823992
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07205390
64Amoebiasis_Homo sapiens_hsa051461.06154185
65Rheumatoid arthritis_Homo sapiens_hsa053231.05707957
66African trypanosomiasis_Homo sapiens_hsa051431.04033357
67Leukocyte transendothelial migration_Homo sapiens_hsa046701.02261767
68Acute myeloid leukemia_Homo sapiens_hsa052211.02190948
69Insulin resistance_Homo sapiens_hsa049311.02039431
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.01739598
71Phagosome_Homo sapiens_hsa041451.01489277
72Starch and sucrose metabolism_Homo sapiens_hsa005001.01437541
73Fructose and mannose metabolism_Homo sapiens_hsa000510.99835453
74Prolactin signaling pathway_Homo sapiens_hsa049170.99728559
75Viral carcinogenesis_Homo sapiens_hsa052030.99253197
76B cell receptor signaling pathway_Homo sapiens_hsa046620.99086007
77Glucagon signaling pathway_Homo sapiens_hsa049220.98378360
78Circadian rhythm_Homo sapiens_hsa047100.97604747
79FoxO signaling pathway_Homo sapiens_hsa040680.96938265
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96784989
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.96379858
82Pancreatic cancer_Homo sapiens_hsa052120.94773970
83Fatty acid elongation_Homo sapiens_hsa000620.94414152
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.94029622
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.93581636
86Systemic lupus erythematosus_Homo sapiens_hsa053220.92995953
87Nucleotide excision repair_Homo sapiens_hsa034200.92719516
88Tight junction_Homo sapiens_hsa045300.91148790
89Small cell lung cancer_Homo sapiens_hsa052220.90774430
90Chronic myeloid leukemia_Homo sapiens_hsa052200.88749280
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88278994
92p53 signaling pathway_Homo sapiens_hsa041150.88268209
93Thyroid cancer_Homo sapiens_hsa052160.86778339
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85930633
95Lysine degradation_Homo sapiens_hsa003100.85869804
96MicroRNAs in cancer_Homo sapiens_hsa052060.85613362
97Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.84311246
98Complement and coagulation cascades_Homo sapiens_hsa046100.82990126
99Endometrial cancer_Homo sapiens_hsa052130.82189998
100Chemokine signaling pathway_Homo sapiens_hsa040620.80773298
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79967635
102Lysosome_Homo sapiens_hsa041420.79344599
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77581381
104Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74930848
105DNA replication_Homo sapiens_hsa030300.73326254
106Dorso-ventral axis formation_Homo sapiens_hsa043200.73061719
107mRNA surveillance pathway_Homo sapiens_hsa030150.72004805
108Caffeine metabolism_Homo sapiens_hsa002320.71791351
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71250558
110Glutathione metabolism_Homo sapiens_hsa004800.69203227
111Non-homologous end-joining_Homo sapiens_hsa034500.68326024
112N-Glycan biosynthesis_Homo sapiens_hsa005100.67877760
113Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66716722
114Shigellosis_Homo sapiens_hsa051310.66622690
115Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65128858
116Butanoate metabolism_Homo sapiens_hsa006500.64642894
117Epstein-Barr virus infection_Homo sapiens_hsa051690.64485413
118Regulation of autophagy_Homo sapiens_hsa041400.64409454
119Proteoglycans in cancer_Homo sapiens_hsa052050.62266521
120T cell receptor signaling pathway_Homo sapiens_hsa046600.62033781
121Oocyte meiosis_Homo sapiens_hsa041140.60778169
122Cysteine and methionine metabolism_Homo sapiens_hsa002700.60597633
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60359209
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.59818869
125mTOR signaling pathway_Homo sapiens_hsa041500.59628285
126Cell cycle_Homo sapiens_hsa041100.59504656
127Fatty acid metabolism_Homo sapiens_hsa012120.58575368
128Non-small cell lung cancer_Homo sapiens_hsa052230.58438624
129Tryptophan metabolism_Homo sapiens_hsa003800.57758930
130Arginine biosynthesis_Homo sapiens_hsa002200.56674409
131RNA polymerase_Homo sapiens_hsa030200.56107449
132Platelet activation_Homo sapiens_hsa046110.55949371
133HIF-1 signaling pathway_Homo sapiens_hsa040660.55534365
134HTLV-I infection_Homo sapiens_hsa051660.53349243
135Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52747879
136TGF-beta signaling pathway_Homo sapiens_hsa043500.50782071
137Collecting duct acid secretion_Homo sapiens_hsa049660.49799808
138Melanoma_Homo sapiens_hsa052180.49551527
139Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48724701
140Vibrio cholerae infection_Homo sapiens_hsa051100.47771637
141Insulin signaling pathway_Homo sapiens_hsa049100.47193472
142Phenylalanine metabolism_Homo sapiens_hsa003600.46639111
143Peroxisome_Homo sapiens_hsa041460.45808670
144Type II diabetes mellitus_Homo sapiens_hsa049300.45458574
145Ether lipid metabolism_Homo sapiens_hsa005650.45179537
146Glycerophospholipid metabolism_Homo sapiens_hsa005640.42832480
147Central carbon metabolism in cancer_Homo sapiens_hsa052300.42679187
148Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42559016
149ABC transporters_Homo sapiens_hsa020100.42251305
150Sphingolipid signaling pathway_Homo sapiens_hsa040710.40659406
151Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40639865
152Renal cell carcinoma_Homo sapiens_hsa052110.40063964
153Mineral absorption_Homo sapiens_hsa049780.39180749
154Adipocytokine signaling pathway_Homo sapiens_hsa049200.38654847
155Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37954326
156Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37902537
157Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37365852
158Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37288382
159Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35070220

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