LAMB4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of water loss via skin (GO:0033561)8.96955244
2desmosome organization (GO:0002934)7.71500502
3keratinization (GO:0031424)7.33022419
4multicellular organismal water homeostasis (GO:0050891)5.77828556
5phosphatidylinositol acyl-chain remodeling (GO:0036149)5.69266863
6water homeostasis (GO:0030104)4.96365458
7phosphatidylserine acyl-chain remodeling (GO:0036150)4.86291102
8phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.66724756
9fucose catabolic process (GO:0019317)4.23504958
10L-fucose metabolic process (GO:0042354)4.23504958
11L-fucose catabolic process (GO:0042355)4.23504958
12keratinocyte proliferation (GO:0043616)4.18510011
13phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.17276735
14keratinocyte development (GO:0003334)4.16255197
15phosphatidylcholine acyl-chain remodeling (GO:0036151)4.03952313
16keratinocyte differentiation (GO:0030216)4.02722193
17lateral sprouting from an epithelium (GO:0060601)3.89333888
18behavioral response to nicotine (GO:0035095)3.85702374
19polarized epithelial cell differentiation (GO:0030859)3.68118261
20epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.56999966
21long-chain fatty acid biosynthetic process (GO:0042759)3.34967547
22photoreceptor cell maintenance (GO:0045494)3.29914668
23platelet dense granule organization (GO:0060155)3.28941268
24indolalkylamine metabolic process (GO:0006586)3.23489968
25epidermal cell differentiation (GO:0009913)3.15277871
26detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.10777251
27piRNA metabolic process (GO:0034587)3.04776448
28detection of light stimulus involved in sensory perception (GO:0050962)3.04470019
29detection of light stimulus involved in visual perception (GO:0050908)3.04470019
30bundle of His cell to Purkinje myocyte communication (GO:0086069)2.99615256
31epidermis development (GO:0008544)2.99233703
32phosphatidylserine metabolic process (GO:0006658)2.98570114
33phosphatidylglycerol metabolic process (GO:0046471)2.96271662
34regulation of acrosome reaction (GO:0060046)2.96246547
35negative regulation of cytosolic calcium ion concentration (GO:0051481)2.95378982
36tryptophan catabolic process (GO:0006569)2.93831209
37indole-containing compound catabolic process (GO:0042436)2.93831209
38indolalkylamine catabolic process (GO:0046218)2.93831209
39kynurenine metabolic process (GO:0070189)2.90233812
40protein localization to cilium (GO:0061512)2.89616964
41molting cycle (GO:0042303)2.88109260
42hair cycle (GO:0042633)2.88109260
43DNA deamination (GO:0045006)2.88007068
44cellular ketone body metabolic process (GO:0046950)2.82973800
45regulation of mesoderm development (GO:2000380)2.82808799
46establishment of tissue polarity (GO:0007164)2.81286840
47establishment of planar polarity (GO:0001736)2.81286840
48serotonin metabolic process (GO:0042428)2.80712361
49behavioral response to ethanol (GO:0048149)2.80200567
50inositol phosphate catabolic process (GO:0071545)2.79422992
51inositol phosphate dephosphorylation (GO:0046855)2.77646145
52phosphorylated carbohydrate dephosphorylation (GO:0046838)2.77646145
53primary amino compound metabolic process (GO:1901160)2.77529026
54phospholipid catabolic process (GO:0009395)2.76674486
55multicellular organism reproduction (GO:0032504)2.75471449
56cornea development in camera-type eye (GO:0061303)2.73812241
57epithelial cilium movement (GO:0003351)2.71066525
58nucleotide transmembrane transport (GO:1901679)2.70618302
59response to pheromone (GO:0019236)2.68340253
60S-adenosylmethionine metabolic process (GO:0046500)2.67825930
61intestinal epithelial cell development (GO:0060576)2.67337121
62regulation of action potential (GO:0098900)2.64605688
63dopamine transport (GO:0015872)2.63621320
64regulation of rhodopsin mediated signaling pathway (GO:0022400)2.61657365
65ketone body metabolic process (GO:1902224)2.58653557
66ectoderm development (GO:0007398)2.58268754
67calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.58043768
68negative regulation of telomere maintenance (GO:0032205)2.57972741
69rhodopsin mediated signaling pathway (GO:0016056)2.57692312
70cardiac right ventricle morphogenesis (GO:0003215)2.57414171
71preassembly of GPI anchor in ER membrane (GO:0016254)2.54134660
72neuronal action potential (GO:0019228)2.53684309
73DNA methylation involved in gamete generation (GO:0043046)2.50606198
74axoneme assembly (GO:0035082)2.50410207
75tryptophan metabolic process (GO:0006568)2.50203148
76parturition (GO:0007567)2.49158000
77indole-containing compound metabolic process (GO:0042430)2.47969810
78regulation of hippo signaling (GO:0035330)2.47830434
79peptide cross-linking (GO:0018149)2.47578148
80intermediate filament organization (GO:0045109)2.44002991
81magnesium ion transport (GO:0015693)2.42936355
82one-carbon compound transport (GO:0019755)2.42529322
83cellular response to sterol (GO:0036315)2.41909991
84polyol catabolic process (GO:0046174)2.41846218
85limb bud formation (GO:0060174)2.41494841
86regulation of hexokinase activity (GO:1903299)2.41202810
87regulation of glucokinase activity (GO:0033131)2.41202810
88glycerophospholipid catabolic process (GO:0046475)2.40051808
89cilium morphogenesis (GO:0060271)2.39992365
90sympathetic nervous system development (GO:0048485)2.39987715
91neural tube formation (GO:0001841)2.38729834
92regulation of cilium movement (GO:0003352)2.37566134
93protein complex biogenesis (GO:0070271)2.36897122
94cilium movement (GO:0003341)2.36749702
95reflex (GO:0060004)2.36646668
96organic cation transport (GO:0015695)2.36404034
97male meiosis I (GO:0007141)2.34859010
98ubiquinone biosynthetic process (GO:0006744)2.31364997
99ubiquinone metabolic process (GO:0006743)2.30817039
100establishment of skin barrier (GO:0061436)11.0003501

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.78992853
2ZNF274_21170338_ChIP-Seq_K562_Hela3.08001932
3RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.65670862
4GBX2_23144817_ChIP-Seq_PC3_Human2.64800326
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.55977526
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.54462828
7IGF1R_20145208_ChIP-Seq_DFB_Human2.24693255
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.24312541
9EZH2_22144423_ChIP-Seq_EOC_Human2.12494885
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.09283922
11CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06155023
12FUS_26573619_Chip-Seq_HEK293_Human1.98835076
13P300_19829295_ChIP-Seq_ESCs_Human1.95081972
14TP63_17297297_ChIP-ChIP_HaCaT_Human1.90642684
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.89538342
16AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.88050411
17TAF15_26573619_Chip-Seq_HEK293_Human1.86925821
18FLI1_27457419_Chip-Seq_LIVER_Mouse1.84562918
19PIAS1_25552417_ChIP-Seq_VCAP_Human1.82242298
20BCAT_22108803_ChIP-Seq_LS180_Human1.77805847
21EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.77379409
22* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.63343736
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.63059716
24* RXR_22108803_ChIP-Seq_LS180_Human1.62599345
25* TCF4_22108803_ChIP-Seq_LS180_Human1.58315990
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.58199057
27AR_21572438_ChIP-Seq_LNCaP_Human1.58175373
28IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.55629871
29CBP_20019798_ChIP-Seq_JUKART_Human1.55629871
30* ER_23166858_ChIP-Seq_MCF-7_Human1.53900883
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53812601
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53527397
33AR_25329375_ChIP-Seq_VCAP_Human1.53146151
34SMAD4_21799915_ChIP-Seq_A2780_Human1.52509009
35EWS_26573619_Chip-Seq_HEK293_Human1.52429449
36* STAT3_23295773_ChIP-Seq_U87_Human1.51610460
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51323073
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45778967
39NR3C1_21868756_ChIP-Seq_MCF10A_Human1.45254194
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42789114
41TCF4_23295773_ChIP-Seq_U87_Human1.41721283
42FOXA1_27270436_Chip-Seq_PROSTATE_Human1.40266667
43FOXA1_25329375_ChIP-Seq_VCAP_Human1.40266667
44NANOG_19829295_ChIP-Seq_ESCs_Human1.40126225
45SOX2_19829295_ChIP-Seq_ESCs_Human1.40126225
46MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36621796
47EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.36280815
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36155269
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.35869270
50SALL1_21062744_ChIP-ChIP_HESCs_Human1.33138662
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.31673870
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.30368595
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29324878
54* GATA3_21878914_ChIP-Seq_MCF-7_Human1.26362465
55BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.25539284
56RUNX2_22187159_ChIP-Seq_PCA_Human1.24587315
57KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24049141
58FOXA1_21572438_ChIP-Seq_LNCaP_Human1.23368769
59* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23272474
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22448938
61* CDX2_22108803_ChIP-Seq_LS180_Human1.21270534
62PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20897921
63EGR1_23403033_ChIP-Seq_LIVER_Mouse1.20804750
64NCOR_22424771_ChIP-Seq_293T_Human1.20611461
65FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20251652
66TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19014378
67* AR_20517297_ChIP-Seq_VCAP_Human1.18576246
68* AUTS2_25519132_ChIP-Seq_293T-REX_Human1.17410671
69REST_21632747_ChIP-Seq_MESCs_Mouse1.15050833
70GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14030020
71PRDM14_20953172_ChIP-Seq_ESCs_Human1.12637728
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12477021
73* CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.12259404
74ETV2_25802403_ChIP-Seq_MESCs_Mouse1.12190222
75TP53_22573176_ChIP-Seq_HFKS_Human1.12078822
76* TP63_23658742_ChIP-Seq_EP156T_Human1.11041298
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10268810
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10268810
79HOXB7_26014856_ChIP-Seq_BT474_Human1.09592720
80CBX2_27304074_Chip-Seq_ESCs_Mouse1.08743026
81SMAD4_21741376_ChIP-Seq_EPCs_Human1.08699626
82SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08150490
83MYC_19829295_ChIP-Seq_ESCs_Human1.07487972
84RNF2_27304074_Chip-Seq_NSC_Mouse1.05558726
85EZH2_27294783_Chip-Seq_NPCs_Mouse1.04605118
86FOXH1_21741376_ChIP-Seq_EPCs_Human1.02703062
87ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02215994
88* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.01662635
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00844059
90TP53_16413492_ChIP-PET_HCT116_Human1.00331006
91NFE2_27457419_Chip-Seq_LIVER_Mouse0.98946514
92FLI1_21867929_ChIP-Seq_TH2_Mouse0.98670382
93BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98330753
94TAF2_19829295_ChIP-Seq_ESCs_Human0.98218743
95POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98127457
96GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.96645195
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95332130
98CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.93453392
99ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92498329
100PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.92146088

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier5.15778876
2MP0000566_synostosis3.95369278
3MP0010234_abnormal_vibrissa_follicle3.49494734
4MP0000383_abnormal_hair_follicle3.45016809
5MP0009780_abnormal_chondrocyte_physiolo3.11020473
6MP0003011_delayed_dark_adaptation2.97576360
7MP0009379_abnormal_foot_pigmentation2.90469437
8MP0005275_abnormal_skin_tensile2.84360592
9MP0005501_abnormal_skin_physiology2.75804185
10MP0010678_abnormal_skin_adnexa2.72918355
11MP0000427_abnormal_hair_cycle2.55931742
12MP0000579_abnormal_nail_morphology2.47271636
13MP0001984_abnormal_olfaction2.38275705
14MP0000647_abnormal_sebaceous_gland2.30498496
15MP0000569_abnormal_digit_pigmentation2.22838062
16MP0005551_abnormal_eye_electrophysiolog2.17355378
17MP0002098_abnormal_vibrissa_morphology2.00742194
18MP0002095_abnormal_skin_pigmentation1.88597353
19MP0010771_integument_phenotype1.87146968
20MP0005645_abnormal_hypothalamus_physiol1.85761459
21MP0002102_abnormal_ear_morphology1.85509923
22MP0004782_abnormal_surfactant_physiolog1.81063348
23MP0004381_abnormal_hair_follicle1.70696888
24MP0009046_muscle_twitch1.70549766
25MP0001968_abnormal_touch/_nociception1.66503281
26MP0001216_abnormal_epidermal_layer1.65864693
27MP0001501_abnormal_sleep_pattern1.65381123
28MP0006072_abnormal_retinal_apoptosis1.63983392
29MP0008877_abnormal_DNA_methylation1.59379277
30MP0003136_yellow_coat_color1.59013990
31MP0003195_calcinosis1.56295242
32MP0008789_abnormal_olfactory_epithelium1.49717932
33MP0002638_abnormal_pupillary_reflex1.49644199
34MP0000372_irregular_coat_pigmentation1.46231507
35MP0000015_abnormal_ear_pigmentation1.41538003
36MP0005646_abnormal_pituitary_gland1.40247584
37MP0008995_early_reproductive_senescence1.39934310
38MP0005174_abnormal_tail_pigmentation1.37306598
39MP0002653_abnormal_ependyma_morphology1.34640500
40MP0002876_abnormal_thyroid_physiology1.34481843
41MP0005253_abnormal_eye_physiology1.33727176
42MP0008872_abnormal_physiological_respon1.33436634
43MP0005499_abnormal_olfactory_system1.28023930
44MP0005394_taste/olfaction_phenotype1.28023930
45MP0004885_abnormal_endolymph1.24885857
46MP0002254_reproductive_system_inflammat1.24309162
47MP0002736_abnormal_nociception_after1.24039169
48MP0004742_abnormal_vestibular_system1.21885858
49MP0004043_abnormal_pH_regulation1.21588772
50MP0003787_abnormal_imprinting1.19070016
51MP0008875_abnormal_xenobiotic_pharmacok1.17969971
52MP0001502_abnormal_circadian_rhythm1.11483473
53MP0004142_abnormal_muscle_tone1.11287568
54MP0005075_abnormal_melanosome_morpholog1.10926818
55MP0009745_abnormal_behavioral_response1.10910288
56MP0001188_hyperpigmentation1.09742732
57MP0001986_abnormal_taste_sensitivity1.09581824
58MP0002272_abnormal_nervous_system1.09031385
59MP0006276_abnormal_autonomic_nervous1.07640497
60MP0004947_skin_inflammation1.06964399
61MP0000631_abnormal_neuroendocrine_gland1.06227849
62MP0003453_abnormal_keratinocyte_physiol1.04153167
63MP0000377_abnormal_hair_follicle1.02470882
64MP0003880_abnormal_central_pattern0.99888458
65MP0003137_abnormal_impulse_conducting0.97676167
66MP0004133_heterotaxia0.96977378
67MP0003646_muscle_fatigue0.90558555
68MP0001486_abnormal_startle_reflex0.90529865
69MP0002060_abnormal_skin_morphology0.90381845
70MP0002938_white_spotting0.87999381
71MP0002557_abnormal_social/conspecific_i0.86138700
72MP0004924_abnormal_behavior0.83806671
73MP0005386_behavior/neurological_phenoty0.83806671
74MP0002177_abnormal_outer_ear0.83788531
75MP0002909_abnormal_adrenal_gland0.82025030
76MP0000367_abnormal_coat/_hair0.81283100
77MP0005647_abnormal_sex_gland0.80749201
78MP0000230_abnormal_systemic_arterial0.80065220
79MP0010329_abnormal_lipoprotein_level0.77527391
80MP0001485_abnormal_pinna_reflex0.77171721
81MP0003950_abnormal_plasma_membrane0.75233931
82MP0006292_abnormal_olfactory_placode0.73773556
83MP0002009_preneoplasia0.73450145
84MP0001756_abnormal_urination0.72757033
85MP0000049_abnormal_middle_ear0.72292557
86MP0003878_abnormal_ear_physiology0.72085458
87MP0005377_hearing/vestibular/ear_phenot0.72085458
88MP0002277_abnormal_respiratory_mucosa0.70006082
89MP0002572_abnormal_emotion/affect_behav0.69818374
90MP0003638_abnormal_response/metabolism_0.68125167
91MP0009931_abnormal_skin_appearance0.67313824
92MP0003938_abnormal_ear_development0.67243651
93MP0003698_abnormal_male_reproductive0.66392365
94MP0003937_abnormal_limbs/digits/tail_de0.65950454
95MP0000538_abnormal_urinary_bladder0.64106213
96MP0002234_abnormal_pharynx_morphology0.62575843
97MP0002184_abnormal_innervation0.62522495
98MP0005085_abnormal_gallbladder_physiolo0.62190172
99MP0002735_abnormal_chemical_nociception0.61780662
100MP0002928_abnormal_bile_duct0.60632526

Predicted human phenotypes

RankGene SetZ-score
1Erythroderma (HP:0001019)4.55578676
2Congenital ichthyosiform erythroderma (HP:0007431)4.48385486
3Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.26386594
4Hypotrichosis (HP:0001006)4.25051581
5Abnormality of secondary sexual hair (HP:0009888)3.71459911
6Abnormality of the axillary hair (HP:0100134)3.71459911
7Conical tooth (HP:0000698)3.51502480
8Parakeratosis (HP:0001036)3.50593860
9Corneal erosion (HP:0200020)3.40819265
10Pancreatic cysts (HP:0001737)3.39395425
11Palmoplantar hyperkeratosis (HP:0000972)3.20248255
12Palmar hyperkeratosis (HP:0010765)3.01985626
13Chronic hepatic failure (HP:0100626)2.99664929
14Abnormality of midbrain morphology (HP:0002418)2.98993970
15Molar tooth sign on MRI (HP:0002419)2.98993970
16Woolly hair (HP:0002224)2.98164548
17Large for gestational age (HP:0001520)2.92380607
18Type II lissencephaly (HP:0007260)2.86986854
19Congenital stationary night blindness (HP:0007642)2.85739766
20Plantar hyperkeratosis (HP:0007556)2.85284703
21True hermaphroditism (HP:0010459)2.84825698
22Erythema (HP:0010783)2.80593527
23Abnormality of the renal cortex (HP:0011035)2.77246033
24Increased IgE level (HP:0003212)2.73348656
25Pancreatic fibrosis (HP:0100732)2.72059540
26Alopecia of scalp (HP:0002293)2.69130046
27Hypoplastic labia majora (HP:0000059)2.66934018
28Polydipsia (HP:0001959)2.66567741
29Abnormal drinking behavior (HP:0030082)2.66567741
30Hypothermia (HP:0002045)2.65897585
31Cerebellar dysplasia (HP:0007033)2.64766755
32Conjunctival hamartoma (HP:0100780)2.64589732
33Sparse eyelashes (HP:0000653)2.60544205
34Gaze-evoked nystagmus (HP:0000640)2.59649420
35Abnormal hair laboratory examination (HP:0003328)2.55279149
36Duplicated collecting system (HP:0000081)2.54317626
37Nephronophthisis (HP:0000090)2.51250181
38Fragile nails (HP:0001808)2.48168334
39Ectropion (HP:0000656)2.45325036
40Tubular atrophy (HP:0000092)2.43866541
41Abnormality of the renal medulla (HP:0100957)2.42098804
42Abnormality of the labia majora (HP:0012881)2.40240121
43Split foot (HP:0001839)2.38376399
44Abnormality of the renal collecting system (HP:0004742)2.33801288
45Attenuation of retinal blood vessels (HP:0007843)2.33359017
46Fair hair (HP:0002286)2.31027885
47Abnormality of permanent molar morphology (HP:0011071)2.29645137
48Abnormality of the dental root (HP:0006486)2.29645137
49Taurodontia (HP:0000679)2.29645137
50Pili torti (HP:0003777)2.27810789
51Medial flaring of the eyebrow (HP:0010747)2.25356055
52Furrowed tongue (HP:0000221)2.25319650
53Cystic liver disease (HP:0006706)2.23473059
54Oligodontia (HP:0000677)2.23428638
55Lip pit (HP:0100267)2.22130432
56Recurrent corneal erosions (HP:0000495)2.21257330
57Hamartoma of the eye (HP:0010568)2.20421468
58Hypohidrosis (HP:0000966)2.19429204
59Abnormality of molar (HP:0011077)2.11998089
60Abnormality of molar morphology (HP:0011070)2.11998089
61Congenital, generalized hypertrichosis (HP:0004540)2.09959184
62Abnormality of the dental pulp (HP:0006479)2.08179916
63Hypomagnesemia (HP:0002917)2.07919118
64Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.07819286
65Abnormality of alanine metabolism (HP:0010916)2.07819286
66Hyperalaninemia (HP:0003348)2.07819286
67Progressive inability to walk (HP:0002505)2.06829730
68Eczematoid dermatitis (HP:0000976)2.06532363
69Thyroid-stimulating hormone excess (HP:0002925)2.05250486
70Concave nail (HP:0001598)2.05013340
71Abolished electroretinogram (ERG) (HP:0000550)2.04366067
72Abnormality of the labia minora (HP:0012880)2.01456354
73Stomach cancer (HP:0012126)2.01146750
74Pendular nystagmus (HP:0012043)1.98715636
75Renal cortical cysts (HP:0000803)1.98480937
76Labial hypoplasia (HP:0000066)1.97382257
77Amelogenesis imperfecta (HP:0000705)1.95127014
78Alacrima (HP:0000522)1.94167936
79Polyuria (HP:0000103)1.92811646
80Palmoplantar keratoderma (HP:0000982)1.92048864
81Decreased circulating renin level (HP:0003351)1.90722994
82Increased corneal curvature (HP:0100692)1.89136434
83Keratoconus (HP:0000563)1.89136434
84Abnormal rod and cone electroretinograms (HP:0008323)1.88646451
85Inability to walk (HP:0002540)1.88106881
86Depressed nasal tip (HP:0000437)1.85518912
87Absent eyelashes (HP:0000561)1.85232101
88Non-midline cleft lip (HP:0100335)1.82915999
89Sparse scalp hair (HP:0002209)1.82906229
90Nasolacrimal duct obstruction (HP:0000579)1.82442283
91Aplasia/Hypoplasia of the tibia (HP:0005772)1.81805779
92Bile duct proliferation (HP:0001408)1.80027988
93Abnormal biliary tract physiology (HP:0012439)1.80027988
94Hypoplasia of the ulna (HP:0003022)1.79158645
95Anterior segment dysgenesis (HP:0007700)1.78955885
96Generalized hypopigmentation of hair (HP:0011358)1.77103542
97Decreased lacrimation (HP:0000633)1.76458553
98Widely spaced teeth (HP:0000687)1.74894055
99Lissencephaly (HP:0001339)1.74830255
100Decreased electroretinogram (ERG) amplitude (HP:0000654)1.72994580

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.14867830
2MAPKAPK33.67836287
3ADRBK23.27766625
4PINK12.67426753
5TGFBR12.47044764
6GRK12.40561314
7WNK32.29081410
8MAP4K22.18361421
9FGFR12.13883471
10BMPR1B2.07520270
11ZAK1.96312608
12STK391.92404994
13TAOK31.89901582
14FGFR21.85309689
15TLK11.84659890
16EEF2K1.84178617
17MAPK131.79289864
18OXSR11.73685532
19WNK41.71443029
20INSRR1.59611867
21PIK3CG1.55712203
22ADRBK11.50048617
23FER1.46609189
24ACVR1B1.46235650
25NUAK11.44597122
26TRPM71.40594333
27MAP3K41.39621132
28PAK31.38947154
29MAPKAPK51.33137949
30PRKCE1.21091330
31MKNK21.14458625
32IKBKB1.10963876
33CSNK1G10.98862319
34TRIM280.96140074
35STK240.96110689
36PRKCG0.95279402
37MINK10.88993146
38GRK70.86958606
39TNIK0.86437889
40CSNK1G30.86232322
41CSNK1G20.85216132
42NME10.84416530
43PIK3CA0.83629430
44PLK20.81695866
45MST40.81375501
46CSNK1A1L0.80793426
47KIT0.78832666
48PRKAA20.78504733
49EIF2AK30.77378654
50MAP2K70.77054227
51STK38L0.76561619
52DYRK20.72481359
53EPHA30.72148677
54CHUK0.69939783
55MARK10.67970886
56STK30.67574797
57BCKDK0.65939817
58AKT30.65283744
59MET0.65113256
60TIE10.64215587
61NLK0.63628583
62PHKG10.63309672
63PHKG20.63309672
64BCR0.62739259
65SGK20.62259419
66FGFR30.61077617
67CSNK1A10.60513649
68MUSK0.58065774
69BRSK20.56377244
70PRKCI0.55392318
71TNK20.55098889
72CAMK2A0.54901853
73CASK0.53753674
74RPS6KB10.53726644
75DAPK20.53703817
76EPHA40.52972863
77NTRK20.51368820
78SGK2230.49945860
79SGK4940.49945860
80EIF2AK20.49154702
81MAP3K70.48593032
82PRKACA0.47587640
83CSNK1D0.46663881
84TEC0.46073133
85PTK2B0.46071561
86MAP2K60.44705046
87STK110.44477767
88MAPK120.44449020
89RPS6KB20.44387140
90VRK10.42787197
91MAP3K60.42479946
92TXK0.42430082
93IRAK10.41405673
94CAMK10.41252544
95PKN10.41174148
96ERBB20.41139045
97IGF1R0.40249526
98FLT30.39178240
99PNCK0.37229331
100DYRK1A0.36046737

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.46242493
2Linoleic acid metabolism_Homo sapiens_hsa005914.17833628
3Phototransduction_Homo sapiens_hsa047444.07733223
4Ether lipid metabolism_Homo sapiens_hsa005653.20136348
5Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.50985315
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.50004298
7Nitrogen metabolism_Homo sapiens_hsa009102.48933237
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.99981078
9Arachidonic acid metabolism_Homo sapiens_hsa005901.98126825
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.83500975
11Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.82108668
12Butanoate metabolism_Homo sapiens_hsa006501.80680766
13Circadian rhythm_Homo sapiens_hsa047101.79700674
14Caffeine metabolism_Homo sapiens_hsa002321.78433524
15Tryptophan metabolism_Homo sapiens_hsa003801.71579993
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.68090039
17Ovarian steroidogenesis_Homo sapiens_hsa049131.61363030
18Nicotine addiction_Homo sapiens_hsa050331.50581842
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47700233
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.45978949
21Dorso-ventral axis formation_Homo sapiens_hsa043201.43635903
22Oxidative phosphorylation_Homo sapiens_hsa001901.42500952
23Olfactory transduction_Homo sapiens_hsa047401.40128716
24Selenocompound metabolism_Homo sapiens_hsa004501.38515545
25Histidine metabolism_Homo sapiens_hsa003401.37756557
26Circadian entrainment_Homo sapiens_hsa047131.33306307
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.31762204
28Primary bile acid biosynthesis_Homo sapiens_hsa001201.29897713
29Serotonergic synapse_Homo sapiens_hsa047261.28028057
30Sphingolipid metabolism_Homo sapiens_hsa006001.25171088
31Steroid hormone biosynthesis_Homo sapiens_hsa001401.24606962
32ABC transporters_Homo sapiens_hsa020101.23979539
33RNA polymerase_Homo sapiens_hsa030201.23178317
34Salivary secretion_Homo sapiens_hsa049701.20848497
35Taste transduction_Homo sapiens_hsa047421.14909715
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.08875686
37Glycerophospholipid metabolism_Homo sapiens_hsa005641.07806926
38Basal transcription factors_Homo sapiens_hsa030221.06084460
39One carbon pool by folate_Homo sapiens_hsa006701.05290316
40Glutamatergic synapse_Homo sapiens_hsa047241.04685645
41Retinol metabolism_Homo sapiens_hsa008301.04665955
42Long-term depression_Homo sapiens_hsa047301.03202557
43Chemical carcinogenesis_Homo sapiens_hsa052040.99327742
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98785958
45Protein export_Homo sapiens_hsa030600.96368260
46Peroxisome_Homo sapiens_hsa041460.96282290
47Homologous recombination_Homo sapiens_hsa034400.95672862
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94714465
49Morphine addiction_Homo sapiens_hsa050320.94303568
50Regulation of autophagy_Homo sapiens_hsa041400.93975111
51Fatty acid biosynthesis_Homo sapiens_hsa000610.89471738
52Collecting duct acid secretion_Homo sapiens_hsa049660.85922263
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.81896171
54Steroid biosynthesis_Homo sapiens_hsa001000.81087639
55Fat digestion and absorption_Homo sapiens_hsa049750.81077149
56Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80783531
57Parkinsons disease_Homo sapiens_hsa050120.80538373
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.76827803
59GABAergic synapse_Homo sapiens_hsa047270.76300260
60Glycerolipid metabolism_Homo sapiens_hsa005610.74579462
61Fatty acid elongation_Homo sapiens_hsa000620.73808234
62Propanoate metabolism_Homo sapiens_hsa006400.73726740
63Calcium signaling pathway_Homo sapiens_hsa040200.69874420
64Amphetamine addiction_Homo sapiens_hsa050310.67099652
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64744384
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64400074
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64119279
68RNA degradation_Homo sapiens_hsa030180.62317853
69Cardiac muscle contraction_Homo sapiens_hsa042600.60492217
70Insulin secretion_Homo sapiens_hsa049110.59787227
71Renin secretion_Homo sapiens_hsa049240.59292358
72Vitamin digestion and absorption_Homo sapiens_hsa049770.59190768
73Dopaminergic synapse_Homo sapiens_hsa047280.58971115
74Metabolic pathways_Homo sapiens_hsa011000.57555349
75Alzheimers disease_Homo sapiens_hsa050100.55633299
76beta-Alanine metabolism_Homo sapiens_hsa004100.54062126
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.54001043
78Mineral absorption_Homo sapiens_hsa049780.52147477
79Intestinal immune network for IgA production_Homo sapiens_hsa046720.50962311
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49176697
81Huntingtons disease_Homo sapiens_hsa050160.48749732
82Fanconi anemia pathway_Homo sapiens_hsa034600.48121746
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47581853
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47440281
85Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.47330495
86Oxytocin signaling pathway_Homo sapiens_hsa049210.45878477
87Sulfur relay system_Homo sapiens_hsa041220.43667882
88Fatty acid degradation_Homo sapiens_hsa000710.42140631
89Ras signaling pathway_Homo sapiens_hsa040140.40987313
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40623455
91Gastric acid secretion_Homo sapiens_hsa049710.38404028
92Cocaine addiction_Homo sapiens_hsa050300.38289727
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.37992892
94cAMP signaling pathway_Homo sapiens_hsa040240.36519344
95Purine metabolism_Homo sapiens_hsa002300.35631812
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.34469976
97Fatty acid metabolism_Homo sapiens_hsa012120.32862973
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28489602
99Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.25020435
100Hedgehog signaling pathway_Homo sapiens_hsa043400.24834957

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