LAMA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the laminin family of secreted molecules. Laminins are heterotrimeric molecules that consist of alpha, beta, and gamma subunits that assemble through a coiled-coil domain. Laminins are essential for formation and function of the basement membrane and have additional functions in regulating cell migration and mechanical signal transduction. This gene encodes an alpha subunit and is responsive to several epithelial-mesenchymal regulators including keratinocyte growth factor, epidermal growth factor and insulin-like growth factor. Mutations in this gene have been identified as the cause of Herlitz type junctional epidermolysis bullosa and laryngoonychocutaneous syndrome. Alternative splicing and alternative promoter usage result in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)7.68080989
2bundle of His cell to Purkinje myocyte communication (GO:0086069)6.50284770
3* cell-substrate junction assembly (GO:0007044)5.18043138
4tooth mineralization (GO:0034505)4.97704811
5regulation of water loss via skin (GO:0033561)4.78257555
6odontogenesis of dentin-containing tooth (GO:0042475)4.60149073
7establishment of skin barrier (GO:0061436)4.43264880
8positive regulation of hair cycle (GO:0042635)4.39308717
9positive regulation of hair follicle development (GO:0051798)4.39308717
10gap junction assembly (GO:0016264)4.35649120
11mesodermal cell differentiation (GO:0048333)4.30765045
12polarized epithelial cell differentiation (GO:0030859)4.13748486
13negative regulation of keratinocyte proliferation (GO:0010839)4.13335214
14odontogenesis (GO:0042476)4.10300160
15establishment of tissue polarity (GO:0007164)4.03722558
16establishment of planar polarity (GO:0001736)4.03722558
17regulation of hair cycle (GO:0042634)4.01109764
18surfactant homeostasis (GO:0043129)3.96304131
19keratinization (GO:0031424)3.90032900
20lung lobe morphogenesis (GO:0060463)3.88547650
21multicellular organismal water homeostasis (GO:0050891)3.88296527
22cell adhesion mediated by integrin (GO:0033627)3.85473963
23renal system development (GO:0072001)3.82817948
24adhesion of symbiont to host cell (GO:0044650)3.82256516
25virion attachment to host cell (GO:0019062)3.82256516
26keratinocyte proliferation (GO:0043616)3.74539482
27interferon-gamma secretion (GO:0072643)3.71818369
28regulation of transforming growth factor beta2 production (GO:0032909)3.70971144
29mammary gland development (GO:0030879)3.69062045
30negative regulation of epidermis development (GO:0045683)3.62034851
31peptidyl-tyrosine autophosphorylation (GO:0038083)3.56812250
32positive regulation of odontogenesis (GO:0042482)3.54205404
33regulation of glomerular filtration (GO:0003093)3.46946290
34keratinocyte differentiation (GO:0030216)3.39368532
35dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.36687418
36* epidermis development (GO:0008544)3.35507935
37regulation of epidermis development (GO:0045682)3.35362885
38intestinal epithelial cell development (GO:0060576)3.30981854
39wound healing, spreading of epidermal cells (GO:0035313)3.26774757
40water homeostasis (GO:0030104)3.24897822
41negative regulation of cell fate specification (GO:0009996)3.23372304
42intermediate filament cytoskeleton organization (GO:0045104)3.19144267
43adhesion of symbiont to host (GO:0044406)3.17559061
44chemical homeostasis within a tissue (GO:0048875)3.17333167
45focal adhesion assembly (GO:0048041)3.14312925
46cell-substrate adherens junction assembly (GO:0007045)3.14312925
47positive regulation of positive chemotaxis (GO:0050927)3.14035991
48regulation of cardioblast differentiation (GO:0051890)3.12693308
49regulation of transforming growth factor beta production (GO:0071634)3.10952806
50glial cell proliferation (GO:0014009)3.09463065
51intermediate filament-based process (GO:0045103)3.07487500
52cellular copper ion homeostasis (GO:0006878)3.06803876
53positive regulation of keratinocyte differentiation (GO:0045618)3.03819664
54L-serine transport (GO:0015825)3.03786638
55branching involved in salivary gland morphogenesis (GO:0060445)3.02934297
56renal system process involved in regulation of blood volume (GO:0001977)3.01989438
57cellular response to vitamin D (GO:0071305)3.00815127
58hair cycle (GO:0042633)2.99906063
59molting cycle (GO:0042303)2.99906063
60epithelial cell-cell adhesion (GO:0090136)2.99338307
61skin morphogenesis (GO:0043589)2.98955332
62regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.98751102
63regulation of positive chemotaxis (GO:0050926)2.96799679
64regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.96564505
65positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.96564505
66cardiac right ventricle morphogenesis (GO:0003215)2.93808708
67regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.91848653
68epithelial cell differentiation involved in prostate gland development (GO:0060742)2.88787443
69regulation of transforming growth factor beta1 production (GO:0032908)2.86827008
70intermediate filament organization (GO:0045109)2.85660813
71regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.85562162
72neural crest cell development (GO:0014032)2.85254086
73heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.85209869
74lung-associated mesenchyme development (GO:0060484)2.84932212
75lung vasculature development (GO:0060426)2.83406245
76tight junction assembly (GO:0070830)2.83083786
77regulation of keratinocyte differentiation (GO:0045616)2.83035533
78negative regulation of cartilage development (GO:0061037)2.82541488
79substrate-dependent cell migration (GO:0006929)2.81436859
80positive regulation of p38MAPK cascade (GO:1900745)2.80478823
81adherens junction organization (GO:0034332)2.79466255
82peptide cross-linking (GO:0018149)2.79298723
83atrioventricular valve morphogenesis (GO:0003181)2.79121936
84cell communication involved in cardiac conduction (GO:0086065)2.79054621
85ectoderm development (GO:0007398)2.77038196
86cytoskeletal anchoring at plasma membrane (GO:0007016)2.75478345
87biomineral tissue development (GO:0031214)2.75081480
88epidermal cell differentiation (GO:0009913)2.75034200
89mammary gland epithelial cell proliferation (GO:0033598)2.73455839
90membrane raft organization (GO:0031579)2.73311025
91adherens junction assembly (GO:0034333)2.72220451
92lateral sprouting from an epithelium (GO:0060601)2.72153432
93regulation of odontogenesis (GO:0042481)2.72150575
94hypotonic response (GO:0006971)2.71362653
95regulation of heart rate by cardiac conduction (GO:0086091)2.70378645
96regulation of metalloenzyme activity (GO:0048552)2.69624528
97positive regulation of epidermal cell differentiation (GO:0045606)2.69258887
98regulation of hippo signaling (GO:0035330)2.69039187
99keratinocyte development (GO:0003334)2.68481667
100hepatocyte differentiation (GO:0070365)2.68474864
101regulation of keratinocyte proliferation (GO:0010837)2.68414412
102regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.68403174
103gland morphogenesis (GO:0022612)2.68120868
104protein localization to endosome (GO:0036010)2.68089812
105* cell junction assembly (GO:0034329)2.66723215
106establishment of epithelial cell polarity (GO:0090162)2.63937607
107regulation of phospholipase A2 activity (GO:0032429)2.63595382
108* cell junction organization (GO:0034330)2.63350421
109* extracellular matrix disassembly (GO:0022617)2.62780234
110collecting duct development (GO:0072044)2.62696549
111cellular response to vitamin (GO:0071295)2.62108213
112filopodium assembly (GO:0046847)2.61866602
113negative regulation of cell fate commitment (GO:0010454)2.61184257
114wound healing, spreading of cells (GO:0044319)2.60631067
115mammary gland alveolus development (GO:0060749)2.60120599
116hormone catabolic process (GO:0042447)2.59766698
117positive regulation of collagen biosynthetic process (GO:0032967)2.58921275
118morphogenesis of embryonic epithelium (GO:0016331)2.58175670
119negative regulation of anoikis (GO:2000811)2.57906525
120semaphorin-plexin signaling pathway (GO:0071526)2.56854454
121serine transport (GO:0032329)2.55733298
122plasma membrane repair (GO:0001778)2.54910075
123skin development (GO:0043588)2.53623823
124regulation of collagen biosynthetic process (GO:0032965)2.52131568
125regulation of hair follicle development (GO:0051797)2.51300049
126negative regulation of chondrocyte differentiation (GO:0032331)2.49936505
127renal filtration (GO:0097205)2.49912446
128endothelial cell morphogenesis (GO:0001886)2.49365039
129cell migration involved in sprouting angiogenesis (GO:0002042)2.48538278
130ventricular cardiac muscle cell action potential (GO:0086005)2.48242566
131calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.47734573
132* endodermal cell differentiation (GO:0035987)2.47135076
133apoptotic cell clearance (GO:0043277)2.46592125
134regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.46591889
135cell surface receptor signaling pathway involved in heart development (GO:0061311)2.46038788
136lymphangiogenesis (GO:0001946)2.44666227
137positive regulation of collagen metabolic process (GO:0010714)2.44212875
138regulation of endothelial cell differentiation (GO:0045601)2.43290536
139regulation of cell fate specification (GO:0042659)2.41948205
140respiratory tube development (GO:0030323)2.41379780
141positive regulation of epidermis development (GO:0045684)2.40924438
142branching involved in prostate gland morphogenesis (GO:0060442)2.38002554
143planar cell polarity pathway involved in neural tube closure (GO:0090179)2.37305207
144lung alveolus development (GO:0048286)2.33116057
145renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.32297885
146wound healing (GO:0042060)2.31522946
147membrane budding (GO:0006900)2.30917979
148positive regulation of biomineral tissue development (GO:0070169)2.30616778
149heart valve morphogenesis (GO:0003179)2.30521095
150* hemidesmosome assembly (GO:0031581)14.3448514

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.68379475
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.48173511
3SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.38875344
4ESR1_21235772_ChIP-Seq_MCF-7_Human3.05388052
5ESR2_21235772_ChIP-Seq_MCF-7_Human2.56150993
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.51032720
7* SOX9_24532713_ChIP-Seq_HFSC_Mouse2.46530838
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.14464032
9SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.10328852
10SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.10328852
11ZNF217_24962896_ChIP-Seq_MCF-7_Human2.05335891
12TP63_17297297_ChIP-ChIP_HaCaT_Human11.7648177
13CDX2_20551321_ChIP-Seq_CACO-2_Human1.98663027
14FOXO3_23340844_ChIP-Seq_DLD1_Human1.98580799
15HIF1A_21447827_ChIP-Seq_MCF-7_Human1.97085011
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.93235716
17ZNF263_19887448_ChIP-Seq_K562_Human1.84812411
18ESR1_20079471_ChIP-ChIP_T-47D_Human1.84337434
19P63_26484246_Chip-Seq_KERATINOCYTES_Human1.75113350
20* SOX2_20726797_ChIP-Seq_SW620_Human1.67462965
21CLOCK_20551151_ChIP-Seq_293T_Human1.65933297
22PPAR_26484153_Chip-Seq_NCI-H1993_Human1.64221873
23CJUN_26792858_Chip-Seq_BT549_Human1.58492044
24SOX2_27498859_Chip-Seq_STOMACH_Mouse1.56963539
25KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.54242255
26TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.52350268
27FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.52338890
28TCF4_18268006_ChIP-ChIP_LS174T_Human1.52213665
29AHR_22903824_ChIP-Seq_MCF-7_Human1.51424062
30GATA1_22025678_ChIP-Seq_K562_Human1.45621281
31RUNX1_27514584_Chip-Seq_MCF-7_Human1.45554922
32GATA4_25053715_ChIP-Seq_YYC3_Human1.40702329
33* KLF5_25053715_ChIP-Seq_YYC3_Human1.40470082
34GATA2_21666600_ChIP-Seq_HMVEC_Human1.37152397
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.33358704
36RACK7_27058665_Chip-Seq_MCF-7_Human1.32882873
37SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.32080609
38GATA6_25053715_ChIP-Seq_YYC3_Human1.31846663
39KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.31676516
40RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.28266410
41ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27339553
42STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.24004496
43TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23777192
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.23696496
45ARNT_22903824_ChIP-Seq_MCF-7_Human1.22689525
46NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.20811342
47FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.20479213
48ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.19149637
49* TP63_23658742_ChIP-Seq_EP156T_Human1.16732563
50ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.15663519
51JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14605587
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12738759
53ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.11463053
54UBF1/2_26484160_Chip-Seq_HMECs_Human1.10665135
55TP63_22573176_ChIP-Seq_HFKS_Human1.10494868
56CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.09894941
57ATF3_27146783_Chip-Seq_COLON_Human1.08662898
58SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.08359247
59EP300_21415370_ChIP-Seq_HL-1_Mouse1.06445194
60TP53_16413492_ChIP-PET_HCT116_Human1.06366998
61LXR_22158963_ChIP-Seq_LIVER_Mouse1.02985656
62JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01022062
63* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.00480017
64GATA3_24758297_ChIP-Seq_MCF-7_Human0.99073756
65ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.98611253
66TP53_18474530_ChIP-ChIP_U2OS_Human0.97113846
67FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96983153
68PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.96109597
69RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94388308
70* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94094790
71PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.92918249
72* AR_21909140_ChIP-Seq_LNCAP_Human0.92479916
73SALL4_18804426_ChIP-ChIP_XEN_Mouse0.90857881
74TCF3_18692474_ChIP-Seq_MEFs_Mouse0.90384738
75AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.88855580
76AR_21572438_ChIP-Seq_LNCaP_Human0.88151911
77TBX20_22080862_ChIP-Seq_HEART_Mouse0.88027384
78TBX20_22328084_ChIP-Seq_HEART_Mouse0.88027384
79PIAS1_25552417_ChIP-Seq_VCAP_Human0.87655964
80UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.86876718
81PPARA_22158963_ChIP-Seq_LIVER_Mouse0.86852459
82* SMAD3_21741376_ChIP-Seq_HESCs_Human0.86760656
83ELK4_26923725_Chip-Seq_MESODERM_Mouse0.86265581
84SALL1_21062744_ChIP-ChIP_HESCs_Human0.85993852
85CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.85257777
86RXR_22108803_ChIP-Seq_LS180_Human0.85201693
87ISL1_27105846_Chip-Seq_CPCs_Mouse0.84764746
88BRD4_25478319_ChIP-Seq_HGPS_Human0.84281882
89STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.83658906
90KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.83379677
91KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.83379677
92KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.83379677
93KDM2B_26808549_Chip-Seq_K562_Human0.83139720
94ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.83081767
95EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.83040062
96ELK3_25401928_ChIP-Seq_HUVEC_Human0.82559741
97P300_27058665_Chip-Seq_ZR-75-30cells_Human0.82509441
98RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.82222686
99FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.81149112
100WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.79948088
101PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.79926468
102EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.79289122
103ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.79252447
104RXR_22158963_ChIP-Seq_LIVER_Mouse0.79177059
105NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.78909657
106NRF2_20460467_ChIP-Seq_MEFs_Mouse0.78638356
107NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.78638356
108TP53_20018659_ChIP-ChIP_R1E_Mouse0.78265093
109TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.76638205
110KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.76395312
111TP53_22127205_ChIP-Seq_IMR90_Human0.73202493
112GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.69119513
113BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.66438001
114HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.64621917
115EGR1_19032775_ChIP-ChIP_M12_Human0.64186907
116TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.63262195
117PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.62135739
118TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.61294743
119TET1_21490601_ChIP-Seq_MESCs_Mouse0.61133181
120TP53_23651856_ChIP-Seq_MEFs_Mouse0.56886115
121ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.56242695
122ERG_21242973_ChIP-ChIP_JURKAT_Human0.53871275
123POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.53665264
124SRY_22984422_ChIP-ChIP_TESTIS_Rat0.52446458
125CTNNB1_20460455_ChIP-Seq_HCT116_Human0.51652315
126NANOG_18692474_ChIP-Seq_MEFs_Mouse0.50224417
127CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.49266713
128ELK1_22589737_ChIP-Seq_MCF10A_Human0.49048126

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat4.99598748
2MP0010234_abnormal_vibrissa_follicle4.46452055
3MP0002796_impaired_skin_barrier3.66988545
4MP0000383_abnormal_hair_follicle3.60732434
5MP0010678_abnormal_skin_adnexa3.42875502
6MP0005275_abnormal_skin_tensile3.27715064
7MP0001849_ear_inflammation3.12745393
8MP0003941_abnormal_skin_development3.04314754
9MP0005409_darkened_coat_color3.03901904
10MP0004272_abnormal_basement_membrane2.99348692
11MP0000579_abnormal_nail_morphology2.92603593
12MP0002060_abnormal_skin_morphology2.88861214
13MP0003705_abnormal_hypodermis_morpholog2.81286315
14MP0003566_abnormal_cell_adhesion2.70304970
15MP0000762_abnormal_tongue_morphology2.65080064
16MP0003453_abnormal_keratinocyte_physiol2.64255084
17MP0000537_abnormal_urethra_morphology2.51025707
18MP0002098_abnormal_vibrissa_morphology2.46921944
19MP0000467_abnormal_esophagus_morphology2.44830915
20MP0002234_abnormal_pharynx_morphology2.42700723
21* MP0001216_abnormal_epidermal_layer2.32370395
22MP0005501_abnormal_skin_physiology2.23473253
23MP0000566_synostosis2.11671054
24MP0010771_integument_phenotype1.85794951
25MP0000377_abnormal_hair_follicle1.85204762
26MP0001346_abnormal_lacrimal_gland1.77820238
27MP0004264_abnormal_extraembryonic_tissu1.71562813
28MP0005023_abnormal_wound_healing1.70773707
29MP0000427_abnormal_hair_cycle1.65564400
30MP0000647_abnormal_sebaceous_gland1.63350357
31MP0000462_abnormal_digestive_system1.62597651
32MP0000538_abnormal_urinary_bladder1.62137861
33MP0003300_gastrointestinal_ulcer1.60909403
34MP0001958_emphysema1.57872338
35MP0009379_abnormal_foot_pigmentation1.57101601
36MP0010352_gastrointestinal_tract_polyps1.56691312
37MP0008260_abnormal_autophagy1.52272520
38MP0009053_abnormal_anal_canal1.46587500
39MP0004782_abnormal_surfactant_physiolog1.45458036
40MP0010368_abnormal_lymphatic_system1.43403753
41MP0009384_cardiac_valve_regurgitation1.41716782
42MP0004947_skin_inflammation1.39942355
43MP0005367_renal/urinary_system_phenotyp1.32075594
44MP0000516_abnormal_urinary_system1.32075594
45MP0010030_abnormal_orbit_morphology1.31082995
46MP0004381_abnormal_hair_follicle1.29746430
47MP0003191_abnormal_cellular_cholesterol1.24437605
48MP0006054_spinal_hemorrhage1.20406694
49MP0000627_abnormal_mammary_gland1.18050040
50MP0002009_preneoplasia1.12968161
51* MP0009931_abnormal_skin_appearance1.12211621
52MP0001851_eye_inflammation1.11842378
53MP0003950_abnormal_plasma_membrane1.11089605
54MP0001879_abnormal_lymphatic_vessel1.11013302
55* MP0000432_abnormal_head_morphology1.07248987
56MP0001191_abnormal_skin_condition1.05581643
57MP0005257_abnormal_intraocular_pressure1.02006046
58* MP0003935_abnormal_craniofacial_develop1.00719103
59MP0003045_fibrosis1.00389546
60MP0003315_abnormal_perineum_morphology0.98345640
61MP0002896_abnormal_bone_mineralization0.96955860
62MP0002282_abnormal_trachea_morphology0.96927901
63MP0002877_abnormal_melanocyte_morpholog0.93946157
64MP0000613_abnormal_salivary_gland0.92141867
65MP0005076_abnormal_cell_differentiation0.89815322
66MP0004019_abnormal_vitamin_homeostasis0.88488239
67MP0002233_abnormal_nose_morphology0.87099483
68MP0005248_abnormal_Harderian_gland0.85142635
69MP0001666_abnormal_nutrient_absorption0.84580994
70MP0000858_altered_metastatic_potential0.84241208
71MP0002177_abnormal_outer_ear0.81737638
72MP0003755_abnormal_palate_morphology0.80898695
73MP0001299_abnormal_eye_distance/0.80879251
74MP0002089_abnormal_postnatal_growth/wei0.78660010
75MP0005394_taste/olfaction_phenotype0.78420614
76MP0005499_abnormal_olfactory_system0.78420614
77MP0003329_amyloid_beta_deposits0.78298908
78MP0010155_abnormal_intestine_physiology0.77833330
79MP0001340_abnormal_eyelid_morphology0.74800381
80MP0001881_abnormal_mammary_gland0.73624322
81MP0000367_abnormal_coat/_hair0.72498634
82MP0008438_abnormal_cutaneous_collagen0.71347092
83MP0003091_abnormal_cell_migration0.70118513
84MP0001243_abnormal_dermal_layer0.69652991
85MP0005360_urolithiasis0.69247496
86MP0005508_abnormal_skeleton_morphology0.68966805
87MP0002295_abnormal_pulmonary_circulatio0.68899907
88MP0005167_abnormal_blood-brain_barrier0.68318667
89MP0003937_abnormal_limbs/digits/tail_de0.68066140
90MP0006138_congestive_heart_failure0.67972000
91MP0000733_abnormal_muscle_development0.67829150
92MP0003115_abnormal_respiratory_system0.67381540
93MP0000163_abnormal_cartilage_morphology0.66768456
94MP0003448_altered_tumor_morphology0.66391156
95MP0005187_abnormal_penis_morphology0.66368476
96MP0005197_abnormal_uvea_morphology0.64502161
97MP0000678_abnormal_parathyroid_gland0.64341957
98MP0009250_abnormal_appendicular_skeleto0.64141449
99MP0001270_distended_abdomen0.62569964
100MP0000534_abnormal_ureter_morphology0.62338954
101MP0002138_abnormal_hepatobiliary_system0.60248086
102MP0005623_abnormal_meninges_morphology0.60240273
103MP0004185_abnormal_adipocyte_glucose0.59717992
104MP0005388_respiratory_system_phenotype0.58504073
105MP0002133_abnormal_respiratory_system0.58504073
106MP0001542_abnormal_bone_strength0.57610523
107MP0009780_abnormal_chondrocyte_physiolo0.57081136
108MP0002697_abnormal_eye_size0.56549260
109MP0000477_abnormal_intestine_morphology0.56330711
110MP0008789_abnormal_olfactory_epithelium0.55376209
111MP0002166_altered_tumor_susceptibility0.55196475
112MP0005193_abnormal_anterior_eye0.55191264
113MP0002109_abnormal_limb_morphology0.55121679
114MP0002909_abnormal_adrenal_gland0.54923156
115MP0005164_abnormal_response_to0.54700024
116MP0003936_abnormal_reproductive_system0.54377721
117MP0002168_other_aberrant_phenotype0.54189211
118MP0002136_abnormal_kidney_physiology0.54113259
119MP0002925_abnormal_cardiovascular_devel0.53979504
120MP0000003_abnormal_adipose_tissue0.47795266
121MP0004858_abnormal_nervous_system0.47541279
122MP0001661_extended_life_span0.47226141
123MP0005330_cardiomyopathy0.44720018
124MP0005621_abnormal_cell_physiology0.44499833
125MP0005451_abnormal_body_composition0.44014411
126MP0003385_abnormal_body_wall0.43811637
127MP0002006_tumorigenesis0.43465719
128MP0004134_abnormal_chest_morphology0.41822031
129MP0000013_abnormal_adipose_tissue0.41596197
130MP0008932_abnormal_embryonic_tissue0.41166592
131MP0002111_abnormal_tail_morphology0.40656951
132MP0001915_intracranial_hemorrhage0.40419229
133MP0001765_abnormal_ion_homeostasis0.40318232
134MP0003183_abnormal_peptide_metabolism0.36334631
135MP0000767_abnormal_smooth_muscle0.33484217

Predicted human phenotypes

RankGene SetZ-score
1* Milia (HP:0001056)9.31012930
2* Onycholysis (HP:0001806)8.97548536
3* Fragile nails (HP:0001808)7.98977749
4* Amelogenesis imperfecta (HP:0000705)7.70468354
5* Atrophic scars (HP:0001075)7.24494158
6* Plantar hyperkeratosis (HP:0007556)6.23182930
7Right ventricular cardiomyopathy (HP:0011663)5.53398150
8Pili torti (HP:0003777)4.29575554
9Thick nail (HP:0001805)4.23457638
10* Nail dystrophy (HP:0008404)4.15851060
11* Hypoplasia of dental enamel (HP:0006297)3.92113982
12Woolly hair (HP:0002224)3.72358311
13Aplasia cutis congenita (HP:0001057)3.66783725
14Alopecia of scalp (HP:0002293)3.59264823
15Palmoplantar hyperkeratosis (HP:0000972)3.54663564
16* Abnormal blistering of the skin (HP:0008066)3.50433033
17Hypotrichosis (HP:0001006)3.49035802
18Sparse scalp hair (HP:0002209)3.35422383
19Palmar hyperkeratosis (HP:0010765)3.33153106
20Esophageal atresia (HP:0002032)3.32795496
21Amniotic constriction ring (HP:0009775)3.27533063
22Abnormality of placental membranes (HP:0011409)3.27533063
23Fragile skin (HP:0001030)3.14437358
24Popliteal pterygium (HP:0009756)2.97907324
25Abnormality of oral frenula (HP:0000190)2.91522667
26Ridged nail (HP:0001807)2.87354190
27Interstitial pulmonary disease (HP:0006530)2.82276054
28Lip pit (HP:0100267)2.77586038
29Abnormal hair laboratory examination (HP:0003328)2.73759589
30Dry hair (HP:0011359)2.72710169
31Bronchomalacia (HP:0002780)2.58241014
32Abnormality of secondary sexual hair (HP:0009888)2.57232419
33Abnormality of the axillary hair (HP:0100134)2.57232419
34Abnormality of nail color (HP:0100643)2.51744405
35Cheilitis (HP:0100825)2.50543123
36Curly hair (HP:0002212)2.50063761
37Pterygium (HP:0001059)2.43629621
38Advanced eruption of teeth (HP:0006288)2.41724086
39Absent eyelashes (HP:0000561)2.40594721
40Abnormality of the salivary glands (HP:0010286)2.37929689
41Xerostomia (HP:0000217)2.36728471
42Ureteral stenosis (HP:0000071)2.36694625
43Neurofibrillary tangles (HP:0002185)2.36507967
44Natal tooth (HP:0000695)2.34008709
45Blepharitis (HP:0000498)2.30533281
46* Hyperhidrosis (HP:0000975)2.26087383
47Oral leukoplakia (HP:0002745)2.22827796
48Premature loss of primary teeth (HP:0006323)2.20049222
49Ureteral obstruction (HP:0006000)2.19912145
50* Hypodontia (HP:0000668)2.17690151
51Abnormality of the gastric mucosa (HP:0004295)2.14269620
52Pustule (HP:0200039)2.11815026
53Periodontitis (HP:0000704)2.09014012
54Fatigable weakness (HP:0003473)2.05462390
55Abnormality of the neuromuscular junction (HP:0003398)2.05462390
56Palmoplantar keratoderma (HP:0000982)2.03897026
57Hyperactive renin-angiotensin system (HP:0000841)2.03736103
58Poikiloderma (HP:0001029)2.03602699
59Shallow orbits (HP:0000586)2.01656515
60Rectal prolapse (HP:0002035)2.00292465
61Oligodontia (HP:0000677)1.99504960
62Septate vagina (HP:0001153)1.97004157
63Cerebral inclusion bodies (HP:0100314)1.95007690
64Mixed hearing impairment (HP:0000410)1.93347185
65Down-sloping shoulders (HP:0200021)1.91868517
66Abnormality of the distal phalanges of the toes (HP:0010182)1.91065531
67Trismus (HP:0000211)1.90841819
68Abnormality of the lacrimal duct (HP:0011481)1.90199354
69Hypoplastic labia majora (HP:0000059)1.90095194
70Distal lower limb muscle weakness (HP:0009053)1.89718760
71* Dehydration (HP:0001944)1.89355425
72Vascular calcification (HP:0004934)1.86868511
73Esophageal varix (HP:0002040)1.86660570
74Acanthosis nigricans (HP:0000956)1.86493930
75Ectropion (HP:0000656)1.84536512
76Cerebral aneurysm (HP:0004944)1.83980511
77Aplasia involving bones of the extremities (HP:0009825)1.83695362
78Aplasia involving bones of the upper limbs (HP:0009823)1.83695362
79Aplasia of the phalanges of the hand (HP:0009802)1.83695362
80Gastrointestinal atresia (HP:0002589)1.83472592
81Erythema (HP:0010783)1.83470338
82Abnormality of the nasal septum (HP:0000419)1.82789226
83Broad metatarsal (HP:0001783)1.82253354
84Ventricular tachycardia (HP:0004756)1.81886683
85Breast hypoplasia (HP:0003187)1.80256883
86Ulnar bowing (HP:0003031)1.79578887
87Short nail (HP:0001799)1.79307513
88* Death in infancy (HP:0001522)1.77368320
89Nasolacrimal duct obstruction (HP:0000579)1.77031361
90Parakeratosis (HP:0001036)1.76933306
91Cardiovascular calcification (HP:0011915)1.76832959
92Flat acetabular roof (HP:0003180)1.72193975
93Epidermoid cyst (HP:0200040)1.71559156
94Aortic aneurysm (HP:0004942)1.71356818
95Selective tooth agenesis (HP:0001592)1.71138537
96Vertebral arch anomaly (HP:0008438)1.70634235
97Labial hypoplasia (HP:0000066)1.69733859
98Hematochezia (HP:0002573)1.69281372
99* Skin ulcer (HP:0200042)1.68262250
100Sparse eyelashes (HP:0000653)1.67900471
101Absent eyebrow (HP:0002223)1.67705534
102Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.65845133
103Abnormality of the labia majora (HP:0012881)1.65330735
104Broad face (HP:0000283)1.64783073
105Split foot (HP:0001839)1.64293611
106Ankyloglossia (HP:0010296)1.63437083
107Corneal dystrophy (HP:0001131)1.62334773
108Hydroxyprolinuria (HP:0003080)1.62186163
109Abnormality of proline metabolism (HP:0010907)1.62186163
110Neonatal short-limb short stature (HP:0008921)1.59352980
111Abnormality of the nasolacrimal system (HP:0000614)1.58409566
112Short hallux (HP:0010109)1.57642872
113Abnormality of permanent molar morphology (HP:0011071)1.57137544
114Abnormality of the dental root (HP:0006486)1.57137544
115Taurodontia (HP:0000679)1.57137544
116Tibial bowing (HP:0002982)1.56950924
117Hypoplastic female external genitalia (HP:0012815)1.56649406
118* Carious teeth (HP:0000670)1.55966425
119Increased connective tissue (HP:0009025)1.55120235
120Abnormality of the 2nd finger (HP:0004100)1.54595417
121Biliary tract neoplasm (HP:0100574)1.54425078
122* Anonychia (HP:0001798)1.54341236
123Cervical subluxation (HP:0003308)1.54246295
124* Pyloric stenosis (HP:0002021)1.54202402
125Laryngomalacia (HP:0001601)1.53871893
126Abnormality of the middle phalanges of the toes (HP:0010183)1.53131687
127Corneal erosion (HP:0200020)1.51655613
128Widely patent fontanelles and sutures (HP:0004492)1.51635644
129Follicular hyperkeratosis (HP:0007502)1.50675754
130Focal segmental glomerulosclerosis (HP:0000097)1.50614847
131* Abnormality of the fingernails (HP:0001231)1.49824828
132Turricephaly (HP:0000262)1.49755014
133Hyporeflexia of lower limbs (HP:0002600)1.49719716
134Back pain (HP:0003418)1.49513089
135Hypoplasia of the uterus (HP:0000013)1.49024484
136Arterial tortuosity (HP:0005116)1.48787933
137Osteolytic defects of the hand bones (HP:0009699)1.47200539
138Osteolytic defects of the phalanges of the hand (HP:0009771)1.47200539
139Abnormal vertebral ossification (HP:0100569)1.46935637
140Aplasia/Hypoplasia of the hallux (HP:0008362)1.46564296
141Neonatal death (HP:0003811)1.46267010
142Abnormality of the distal phalanx of the thumb (HP:0009617)1.45996044
143Abnormality of molar morphology (HP:0011070)1.43855756
144Abnormality of molar (HP:0011077)1.43855756
145Abnormality of the alveolar ridges (HP:0006477)1.38558563

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA26.06170376
2ARAF4.77366805
3MST1R3.39947717
4LATS13.34433227
5MST43.24514511
6NTRK13.11803324
7MAP3K33.09073714
8PIM23.01466727
9FER2.79996830
10EPHB22.68112611
11RIPK12.42622046
12MAP3K92.39720962
13EPHB12.34025139
14TGFBR22.20905337
15ERN12.03890215
16PTK62.03416272
17TIE11.97562264
18FRK1.93810836
19MAP3K21.93042892
20EPHA31.74277874
21MAPK151.73300220
22MET1.71039202
23MAPKAPK31.70575351
24KSR21.70124191
25PTK21.68817020
26FLT31.62673543
27LRRK21.61169864
28FGFR21.52630762
29FGFR41.50511810
30RPS6KB21.47600241
31BRAF1.42900720
32TRPM71.39240010
33MAP2K21.35026367
34STK101.31956971
35RAF11.31116173
36SIK11.28179385
37LMTK21.27842474
38STK241.25786213
39NME11.23269141
40STK38L1.18253487
41STK31.17865279
42CDK61.14908791
43FGFR31.14511789
44TESK11.13640522
45TRIB31.10757015
46MAP3K71.07760374
47RPS6KA21.06321550
48DMPK1.04897168
49PAK41.04220925
50TGFBR11.03942456
51NUAK11.00611502
52TTN0.98065108
53BMX0.96196535
54MAP3K140.96012780
55DDR20.94722498
56CDK120.91233806
57FGFR10.88230960
58MAP3K60.88090991
59MAP3K130.87499336
60MAP3K120.85862330
61ERBB20.85526099
62CSF1R0.83556082
63PDGFRA0.83167094
64TYK20.78270883
65ROCK20.76351914
66ERBB30.76105277
67MAP2K10.75921588
68CHUK0.75519582
69SMG10.75433419
70STK380.73384273
71GSK3A0.72750304
72MAP3K10.72518861
73LATS20.67062467
74PDGFRB0.63441081
75PIK3CA0.63012527
76KSR10.62056734
77NLK0.61395214
78PRKG20.61028175
79MOS0.58196408
80PAK20.56772600
81PRKD10.54214639
82DYRK1B0.53700491
83PKN20.53652515
84NME20.51673213
85EEF2K0.51446102
86RPS6KA40.49635135
87MAPKAPK20.47625475
88ERBB40.46652187
89PBK0.46334184
90BCR0.46272196
91MAP3K80.46059506
92AKT30.44748645
93PRKCI0.44666200
94RET0.44014615
95RPS6KC10.43080213
96RPS6KL10.43080213
97ROCK10.42246081
98NEK60.40973884
99CAMK1G0.40417378
100MATK0.40358906
101SGK30.40141890
102PTK2B0.40032152
103IRAK30.39897948
104PRPF4B0.39844366
105CSK0.38659559
106MELK0.38583505
107MTOR0.38453123
108PRKAA20.37923392
109EGFR0.37027688
110DAPK20.36813179
111PRKD20.35837854
112SRC0.35837730
113TAOK10.35716809
114MYLK0.35204287
115SCYL20.34543476
116PDK20.33361340
117JAK10.33270976
118EIF2AK20.32099481
119INSR0.32022814
120WNK10.30725556
121WNK40.30603383
122RPS6KA60.29674948
123IGF1R0.29520239
124MAPKAPK50.29363782
125KDR0.28696967
126RPS6KA10.26938511
127HIPK20.26660178
128RPS6KB10.26087977
129ICK0.25919886
130CDC42BPA0.25786895
131PRKCE0.25780634
132GRK10.24561708
133ABL10.24512137
134CAMK1D0.24172115
135MAP2K60.24098261
136JAK20.23370414
137PHKG10.23035927
138PHKG20.23035927
139FYN0.22843102
140PIK3CG0.22722961
141CAMK2G0.22313904
142INSRR0.20644758
143JAK30.20521306
144ABL20.19944021
145PAK30.19092403

Predicted pathways (KEGG)

RankGene SetZ-score
1* ECM-receptor interaction_Homo sapiens_hsa045123.74108020
2Adherens junction_Homo sapiens_hsa045202.51443108
3* Small cell lung cancer_Homo sapiens_hsa052222.34265038
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.34195603
5Steroid biosynthesis_Homo sapiens_hsa001002.26314632
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.20623635
7Basal cell carcinoma_Homo sapiens_hsa052172.13230061
8* Amoebiasis_Homo sapiens_hsa051462.02670616
9* Focal adhesion_Homo sapiens_hsa045102.01797871
10Hippo signaling pathway_Homo sapiens_hsa043902.01488558
11Mineral absorption_Homo sapiens_hsa049781.98466881
12Caffeine metabolism_Homo sapiens_hsa002321.94670539
13Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.93116614
14Tight junction_Homo sapiens_hsa045301.84953665
15p53 signaling pathway_Homo sapiens_hsa041151.82917593
16Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.82833988
17Proteoglycans in cancer_Homo sapiens_hsa052051.79538924
18Protein digestion and absorption_Homo sapiens_hsa049741.79312181
19ErbB signaling pathway_Homo sapiens_hsa040121.78820687
20Bladder cancer_Homo sapiens_hsa052191.69696924
21* Toxoplasmosis_Homo sapiens_hsa051451.65329970
22Leukocyte transendothelial migration_Homo sapiens_hsa046701.62790635
23Hedgehog signaling pathway_Homo sapiens_hsa043401.51892583
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.46776695
25Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.42985827
26TGF-beta signaling pathway_Homo sapiens_hsa043501.42317847
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.41590245
28AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.41068217
29Central carbon metabolism in cancer_Homo sapiens_hsa052301.26962217
30Prion diseases_Homo sapiens_hsa050201.20637672
31Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.16558194
32Glioma_Homo sapiens_hsa052141.13186365
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.11090712
34Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.10366735
35Hepatitis C_Homo sapiens_hsa051601.09911298
36Bile secretion_Homo sapiens_hsa049761.07581697
37* Pathways in cancer_Homo sapiens_hsa052001.05312391
38Dorso-ventral axis formation_Homo sapiens_hsa043201.04601091
39Sulfur metabolism_Homo sapiens_hsa009201.03491605
40MicroRNAs in cancer_Homo sapiens_hsa052061.02722575
41Histidine metabolism_Homo sapiens_hsa003401.01663183
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.00322870
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98566421
44Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.98285138
45Endometrial cancer_Homo sapiens_hsa052130.96612044
46Notch signaling pathway_Homo sapiens_hsa043300.95010780
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.92737387
48Fat digestion and absorption_Homo sapiens_hsa049750.92450199
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91466090
50Regulation of actin cytoskeleton_Homo sapiens_hsa048100.91446180
51Renin-angiotensin system_Homo sapiens_hsa046140.91314368
52* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.91070009
53Shigellosis_Homo sapiens_hsa051310.90641395
54Thyroid cancer_Homo sapiens_hsa052160.89710780
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.89355835
56Thyroid hormone synthesis_Homo sapiens_hsa049180.88627455
57Inositol phosphate metabolism_Homo sapiens_hsa005620.86935618
58Insulin resistance_Homo sapiens_hsa049310.84486404
59Rap1 signaling pathway_Homo sapiens_hsa040150.83425620
60Pancreatic cancer_Homo sapiens_hsa052120.82784295
61Vitamin digestion and absorption_Homo sapiens_hsa049770.82665732
62Non-small cell lung cancer_Homo sapiens_hsa052230.82638412
63Dilated cardiomyopathy_Homo sapiens_hsa054140.82409761
64Prostate cancer_Homo sapiens_hsa052150.82244164
65Melanogenesis_Homo sapiens_hsa049160.81936994
66Wnt signaling pathway_Homo sapiens_hsa043100.81002357
67N-Glycan biosynthesis_Homo sapiens_hsa005100.80934549
68Axon guidance_Homo sapiens_hsa043600.80170762
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79905441
70Renin secretion_Homo sapiens_hsa049240.78766787
71TNF signaling pathway_Homo sapiens_hsa046680.78729348
72Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.78388707
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77692086
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76346017
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75265865
76Insulin signaling pathway_Homo sapiens_hsa049100.74492719
77Chemical carcinogenesis_Homo sapiens_hsa052040.74135109
78Chronic myeloid leukemia_Homo sapiens_hsa052200.72556164
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71050323
80Phenylalanine metabolism_Homo sapiens_hsa003600.67810746
81Arachidonic acid metabolism_Homo sapiens_hsa005900.67214483
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66510418
83VEGF signaling pathway_Homo sapiens_hsa043700.66182552
84Fatty acid biosynthesis_Homo sapiens_hsa000610.65364166
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65046358
86Endocytosis_Homo sapiens_hsa041440.64321332
87PPAR signaling pathway_Homo sapiens_hsa033200.63597682
88Malaria_Homo sapiens_hsa051440.63186607
89Glycerolipid metabolism_Homo sapiens_hsa005610.61906315
90Gastric acid secretion_Homo sapiens_hsa049710.60719675
91Complement and coagulation cascades_Homo sapiens_hsa046100.60082840
92Starch and sucrose metabolism_Homo sapiens_hsa005000.59131860
93Galactose metabolism_Homo sapiens_hsa000520.58523028
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58423014
95Renal cell carcinoma_Homo sapiens_hsa052110.58049586
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57564143
97Glutathione metabolism_Homo sapiens_hsa004800.56725849
98Platelet activation_Homo sapiens_hsa046110.56490896
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55692922
100Linoleic acid metabolism_Homo sapiens_hsa005910.55408880
101Hematopoietic cell lineage_Homo sapiens_hsa046400.55271166
102Fatty acid degradation_Homo sapiens_hsa000710.53690462
103Pertussis_Homo sapiens_hsa051330.53446136
104GnRH signaling pathway_Homo sapiens_hsa049120.52702971
105Influenza A_Homo sapiens_hsa051640.52303219
106Pancreatic secretion_Homo sapiens_hsa049720.50941197
107Apoptosis_Homo sapiens_hsa042100.49216780
108Sphingolipid metabolism_Homo sapiens_hsa006000.48311506
109Jak-STAT signaling pathway_Homo sapiens_hsa046300.47017822
110ABC transporters_Homo sapiens_hsa020100.46033967
111Melanoma_Homo sapiens_hsa052180.44832368
112Salivary secretion_Homo sapiens_hsa049700.44765008
113Estrogen signaling pathway_Homo sapiens_hsa049150.44454852
114HTLV-I infection_Homo sapiens_hsa051660.43836783
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.43313703
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.42490275
117Lysosome_Homo sapiens_hsa041420.42033183
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41104288
119NOD-like receptor signaling pathway_Homo sapiens_hsa046210.40853085
120Salmonella infection_Homo sapiens_hsa051320.40849350
121Prolactin signaling pathway_Homo sapiens_hsa049170.40110299
122Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39964230
123mTOR signaling pathway_Homo sapiens_hsa041500.39384237
124Acute myeloid leukemia_Homo sapiens_hsa052210.38880923
125Gap junction_Homo sapiens_hsa045400.33257413
126Colorectal cancer_Homo sapiens_hsa052100.32090886
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.31973524
128AMPK signaling pathway_Homo sapiens_hsa041520.31328370
129Long-term depression_Homo sapiens_hsa047300.28601799
130Glucagon signaling pathway_Homo sapiens_hsa049220.27266317
131Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.26046354
132Glycosaminoglycan degradation_Homo sapiens_hsa005310.25417989
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.23600248
134HIF-1 signaling pathway_Homo sapiens_hsa040660.23045424
135Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.22841514
136Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.22115969
137FoxO signaling pathway_Homo sapiens_hsa040680.21272042
138Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.21236852

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