LAIR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the immunoglobulin superfamily. It was identified by its similarity to leukocyte-associated immunoglobulin-like receptor 1, a membrane-bound receptor that modulates innate immune response. The protein encoded by this locus is a soluble receptor that may play roles in both inhibition of collagen-induced platelet aggregation and vessel formation during placental implantation. This gene maps to a region of 19q13.4, termed the leukocyte receptor cluster, which contains 29 genes in the immunoglobulin superfamily. Alternatively spliced transcript variants have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)9.84276258
2antigen processing and presentation via MHC class Ib (GO:0002475)9.73003525
3histone H4-K12 acetylation (GO:0043983)9.10442046
4antigen processing and presentation of endogenous antigen (GO:0019883)8.58494371
5maturation of 5.8S rRNA (GO:0000460)8.13968504
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)8.12374020
7negative regulation of protein oligomerization (GO:0032460)7.52554024
8regulation of antigen processing and presentation of peptide antigen (GO:0002583)7.47785775
9protein import into peroxisome matrix (GO:0016558)7.29816742
10macrophage activation involved in immune response (GO:0002281)7.09921374
11microglial cell activation (GO:0001774)6.83297644
12nucleotide transmembrane transport (GO:1901679)6.58141636
13macrophage chemotaxis (GO:0048246)6.16822268
14DNA strand renaturation (GO:0000733)6.06302221
15T-helper 1 type immune response (GO:0042088)6.00097133
16DNA deamination (GO:0045006)5.56969058
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.13547108
18regulation of protein homooligomerization (GO:0032462)5.11549834
19adaptation of signaling pathway (GO:0023058)5.11123192
20autophagic vacuole fusion (GO:0000046)5.08393201
21regulation of isotype switching to IgG isotypes (GO:0048302)4.93874986
22positive regulation of antigen processing and presentation (GO:0002579)4.78488634
23platelet dense granule organization (GO:0060155)4.75105621
24protein localization to peroxisome (GO:0072662)4.69942384
25protein targeting to peroxisome (GO:0006625)4.69942384
26establishment of protein localization to peroxisome (GO:0072663)4.69942384
27T cell migration (GO:0072678)4.67492330
28cellular defense response (GO:0006968)4.55372185
29regulation of monocyte differentiation (GO:0045655)4.53475376
30peroxisomal transport (GO:0043574)4.41994820
31myeloid cell activation involved in immune response (GO:0002275)4.35863519
32negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.33937725
33negative regulation of cell killing (GO:0031342)4.33937725
34lipopolysaccharide biosynthetic process (GO:0009103)4.33714082
35immunoglobulin mediated immune response (GO:0016064)4.23543219
36positive regulation of T cell mediated cytotoxicity (GO:0001916)4.23244141
37fatty acid elongation (GO:0030497)4.17412685
38lipopolysaccharide metabolic process (GO:0008653)4.14440837
39thrombin receptor signaling pathway (GO:0070493)4.05502015
40positive regulation of natural killer cell mediated immunity (GO:0002717)4.02501828
41lymphocyte migration (GO:0072676)3.98958200
42positive regulation of B cell differentiation (GO:0045579)3.93092014
43peroxisome organization (GO:0007031)3.92644509
44regulation of posttranscriptional gene silencing (GO:0060147)3.92378018
45regulation of gene silencing by miRNA (GO:0060964)3.92378018
46regulation of gene silencing by RNA (GO:0060966)3.92378018
47organelle membrane fusion (GO:0090174)3.91502149
48macrophage activation (GO:0042116)3.80177226
49positive regulation of isotype switching (GO:0045830)3.76421068
50cellular response to interleukin-15 (GO:0071350)3.74430045
51regulation of antigen processing and presentation (GO:0002577)3.70268729
52positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.64863315
53negative regulation of glycogen biosynthetic process (GO:0045719)3.64479247
54positive regulation of mast cell activation (GO:0033005)3.63403840
55regulation of T cell mediated cytotoxicity (GO:0001914)3.63005811
56cytidine deamination (GO:0009972)3.62749595
57cytidine metabolic process (GO:0046087)3.62749595
58cytidine catabolic process (GO:0006216)3.62749595
59regulation of natural killer cell mediated immunity (GO:0002715)3.56762704
60regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.56762704
61chemokine-mediated signaling pathway (GO:0070098)3.47445103
62positive regulation of mast cell degranulation (GO:0043306)3.39464703
63positive regulation of mast cell activation involved in immune response (GO:0033008)3.39464703
64negative regulation of gene silencing (GO:0060969)3.34782608
65positive regulation of DNA recombination (GO:0045911)3.30663489
66B cell mediated immunity (GO:0019724)3.22069158
67positive regulation of cell killing (GO:0031343)3.17807156
68negative regulation of granulocyte differentiation (GO:0030853)3.17671232
69regulation of leukocyte mediated cytotoxicity (GO:0001910)3.17394592
70regulation of B cell differentiation (GO:0045577)3.16113754
71intracellular protein transmembrane import (GO:0044743)3.15741530
72negative regulation of bone resorption (GO:0045779)3.12382275
73RNA methylation (GO:0001510)3.12129781
74cytolysis (GO:0019835)3.12060173
75pyrimidine ribonucleoside catabolic process (GO:0046133)3.09571335
76negative regulation of B cell proliferation (GO:0030889)3.07351389
77positive regulation of immunoglobulin mediated immune response (GO:0002891)3.04430408
78positive regulation of B cell mediated immunity (GO:0002714)3.04430408
79DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.02559842
80positive regulation of lymphocyte mediated immunity (GO:0002708)3.00800594
81nucleotide transport (GO:0006862)2.98735287
82neutrophil activation involved in immune response (GO:0002283)2.96877608
83mast cell activation involved in immune response (GO:0002279)2.96570088
84mast cell degranulation (GO:0043303)2.96570088
85positive regulation of leukocyte mediated immunity (GO:0002705)2.94443038
86response to interleukin-15 (GO:0070672)2.91428090
87negative regulation of telomere maintenance (GO:0032205)2.88778791
88negative regulation of glycogen metabolic process (GO:0070874)2.88554317
89positive regulation of T cell mediated immunity (GO:0002711)2.87901527
90mast cell activation (GO:0045576)2.81289005
91positive regulation of interleukin-17 production (GO:0032740)2.80705087
92regulation of cell killing (GO:0031341)2.78647983
93DNA damage response, signal transduction resulting in transcription (GO:0042772)2.77611802
94positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.77272735
95type I interferon signaling pathway (GO:0060337)2.75810629
96cellular response to type I interferon (GO:0071357)2.75810629
97modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.75536998
98positive regulation by organism of defense response of other organism involved in symbiotic interact2.75536998
99modulation by symbiont of host immune response (GO:0052553)2.75536998
100modulation by symbiont of host defense response (GO:0052031)2.75536998

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.55447257
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.50788175
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human6.22677953
4ELF1_17652178_ChIP-ChIP_JURKAT_Human4.55282305
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.17851861
6STAT6_21828071_ChIP-Seq_BEAS2B_Human3.10957846
7RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.06914771
8RUNX_20019798_ChIP-Seq_JUKART_Human2.93644833
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.91107251
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.89482425
11STAT4_19710469_ChIP-ChIP_TH1__Mouse2.79099719
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.45590152
13IKZF1_21737484_ChIP-ChIP_HCT116_Human2.44024483
14NOTCH1_21737748_ChIP-Seq_TLL_Human2.26017923
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.24397225
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.21772004
17BMI1_19503595_ChIP-Seq_MEFsC_Mouse2.14016363
18LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.08501342
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.07661288
20SCL_19346495_ChIP-Seq_HPC-7_Human2.03913079
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.02247393
22MAF_26560356_Chip-Seq_TH1_Human1.98402181
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.96047208
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.89322026
25LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.80745702
26CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.70410342
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.67023828
28SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.64635871
29IRF8_27001747_Chip-Seq_BMDM_Mouse1.62741938
30E2F7_22180533_ChIP-Seq_HELA_Human1.60162836
31GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.60029660
32CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.50817091
33* MYB_26560356_Chip-Seq_TH2_Human1.47677500
34VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.47059594
35GATA1_19941826_ChIP-Seq_K562_Human1.46062528
36MYB_26560356_Chip-Seq_TH1_Human1.38404299
37* TDRD3_21172665_ChIP-Seq_MCF-7_Human1.32543650
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.27783477
39SPI1_23547873_ChIP-Seq_NB4_Human1.26961524
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.26478915
41GATA3_26560356_Chip-Seq_TH2_Human1.26331963
42SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23716444
43PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.22689863
44NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22341452
45GATA3_27048872_Chip-Seq_THYMUS_Human1.21819494
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.21709752
47EGR1_19032775_ChIP-ChIP_M12_Human1.20075585
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.18988878
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18396318
50TRIM28_21343339_ChIP-Seq_HEK293_Human1.17995172
51VDR_24763502_ChIP-Seq_THP-1_Human1.16486392
52* UTX_26944678_Chip-Seq_JUKART_Human1.15808659
53* BCL6_27268052_Chip-Seq_Bcells_Human1.15779401
54* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.15489995
55PU_27001747_Chip-Seq_BMDM_Mouse1.14108023
56BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09684359
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09670739
58EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09307917
59SPI1_23127762_ChIP-Seq_K562_Human1.06867701
60SA1_27219007_Chip-Seq_ERYTHROID_Human1.04457199
61SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.03510458
62* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.02407997
63MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.00368309
64SA1_27219007_Chip-Seq_Bcells_Human0.99822284
65EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.99179379
66* TAF2_19829295_ChIP-Seq_ESCs_Human0.98484835
67BRD4_27068464_Chip-Seq_AML-cells_Mouse0.95914211
68* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95645517
69E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.94989076
70CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.88960125
71SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.88950729
72EED_16625203_ChIP-ChIP_MESCs_Mouse0.88855095
73P63_26484246_Chip-Seq_KERATINOCYTES_Human0.87487020
74DROSHA_22980978_ChIP-Seq_HELA_Human0.85478363
75SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.85099586
76GATA6_21074721_ChIP-Seq_CACO-2_Human0.84880643
77KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.84803668
78KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.84803668
79KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.84803668
80SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.82717204
81EGR1_23403033_ChIP-Seq_LIVER_Mouse0.82124596
82STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.81753489
83* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.80599121
84* ELF1_20517297_ChIP-Seq_JURKAT_Human0.80548731
85VDR_21846776_ChIP-Seq_THP-1_Human0.80477842
86HTT_18923047_ChIP-ChIP_STHdh_Human0.78355000
87SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77097427
88GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.77051908
89RARB_24833708_ChIP-Seq_LIVER_Mouse0.76401109
90* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.76110985
91FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.75968221
92RAD21_21589869_ChIP-Seq_MESCs_Mouse0.75868768
93SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.75388550
94* NANOG_20526341_ChIP-Seq_ESCs_Human0.74847805
95MYC_19915707_ChIP-ChIP_AK7_Human0.74101897
96AR_20517297_ChIP-Seq_VCAP_Human0.74080617
97* E2F1_20622854_ChIP-Seq_HELA_Human0.74056163
98FOXH1_21741376_ChIP-Seq_ESCs_Human0.74045399
99CRX_20693478_ChIP-Seq_RETINA_Mouse0.73733861
100GATA1_19941827_ChIP-Seq_MEL_Mouse0.72912158

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006082_CNS_inflammation9.19156709
2MP0002254_reproductive_system_inflammat6.27872798
3MP0005671_abnormal_response_to5.03730145
4MP0001873_stomach_inflammation3.77662083
5MP0000685_abnormal_immune_system3.48216343
6MP0001835_abnormal_antigen_presentation3.37895613
7MP0003690_abnormal_glial_cell2.98116761
8MP0003300_gastrointestinal_ulcer2.93049288
9MP0009333_abnormal_splenocyte_physiolog2.84564479
10MP0002132_abnormal_respiratory_system2.70323137
11MP0001348_abnormal_lacrimal_gland2.67576426
12MP0009785_altered_susceptibility_to2.44169005
13MP0003878_abnormal_ear_physiology2.30217675
14MP0005377_hearing/vestibular/ear_phenot2.30217675
15MP0002876_abnormal_thyroid_physiology2.20914643
16MP0005000_abnormal_immune_tolerance2.20378428
17MP0005025_abnormal_response_to2.16894204
18MP0002837_dystrophic_cardiac_calcinosis2.15840599
19MP0002102_abnormal_ear_morphology2.13104865
20MP0001346_abnormal_lacrimal_gland2.06311729
21MP0001790_abnormal_immune_system1.92976350
22MP0005387_immune_system_phenotype1.92976350
23MP0002419_abnormal_innate_immunity1.84171749
24MP0002166_altered_tumor_susceptibility1.84017232
25MP0003436_decreased_susceptibility_to1.81243756
26MP0001800_abnormal_humoral_immune1.76301976
27MP0003879_abnormal_hair_cell1.72331705
28MP0002420_abnormal_adaptive_immunity1.69199683
29MP0002405_respiratory_system_inflammati1.67738137
30MP0003724_increased_susceptibility_to1.67722173
31MP0002148_abnormal_hypersensitivity_rea1.66103830
32MP0001819_abnormal_immune_cell1.65842778
33MP0003763_abnormal_thymus_physiology1.65207806
34MP0002452_abnormal_antigen_presenting1.63593566
35MP0002723_abnormal_immune_serum1.59393333
36MP0010155_abnormal_intestine_physiology1.51865574
37MP0005166_decreased_susceptibility_to1.42701132
38MP0002006_tumorigenesis1.40958388
39MP0000920_abnormal_myelination1.36629132
40MP0002277_abnormal_respiratory_mucosa1.32228983
41MP0004883_abnormal_blood_vessel1.29396028
42MP0000716_abnormal_immune_system1.26084379
43MP0005310_abnormal_salivary_gland1.23214031
44MP0000858_altered_metastatic_potential1.21660487
45MP0003448_altered_tumor_morphology1.20656569
46MP0003866_abnormal_defecation1.19930934
47MP0002138_abnormal_hepatobiliary_system1.15864187
48MP0001845_abnormal_inflammatory_respons1.13678224
49MP0001915_intracranial_hemorrhage1.11605456
50MP0005595_abnormal_vascular_smooth1.05726597
51MP0002998_abnormal_bone_remodeling1.05243739
52MP0005464_abnormal_platelet_physiology1.00526877
53MP0002933_joint_inflammation0.98850158
54MP0000703_abnormal_thymus_morphology0.96619976
55MP0001663_abnormal_digestive_system0.95661960
56MP0002398_abnormal_bone_marrow0.95460487
57MP0009763_increased_sensitivity_to0.93722495
58MP0008469_abnormal_protein_level0.93011108
59MP0005164_abnormal_response_to0.90819778
60MP0002429_abnormal_blood_cell0.87948193
61MP0001851_eye_inflammation0.86705707
62MP0002722_abnormal_immune_system0.86274462
63MP0005647_abnormal_sex_gland0.83007050
64MP0003183_abnormal_peptide_metabolism0.82981621
65MP0001919_abnormal_reproductive_system0.81153598
66MP0000689_abnormal_spleen_morphology0.80662685
67MP0002693_abnormal_pancreas_physiology0.79013181
68MP0005197_abnormal_uvea_morphology0.78744912
69MP0008260_abnormal_autophagy0.76496376
70MP0008873_increased_physiological_sensi0.73434658
71MP0000613_abnormal_salivary_gland0.72849456
72MP0003303_peritoneal_inflammation0.72759564
73MP0001533_abnormal_skeleton_physiology0.70237275
74MP0001188_hyperpigmentation0.63820831
75MP0003075_altered_response_to0.63521731
76MP0005381_digestive/alimentary_phenotyp0.63026013
77MP0009765_abnormal_xenobiotic_induced0.61356793
78MP0000249_abnormal_blood_vessel0.60060644
79MP0004742_abnormal_vestibular_system0.56776742
80MP0001119_abnormal_female_reproductive0.56543020
81MP0000465_gastrointestinal_hemorrhage0.55339574
82MP0005360_urolithiasis0.53479327
83MP0009764_decreased_sensitivity_to0.52781673
84MP0004185_abnormal_adipocyte_glucose0.52506829
85MP0003567_abnormal_fetal_cardiomyocyte0.51090798
86MP0003045_fibrosis0.48511109
87MP0005448_abnormal_energy_balance0.47145425
88MP0001485_abnormal_pinna_reflex0.45939323
89MP0001984_abnormal_olfaction0.44218677
90MP0003950_abnormal_plasma_membrane0.43367036
91MP0005023_abnormal_wound_healing0.43121466
92MP0003252_abnormal_bile_duct0.43050735
93MP0005389_reproductive_system_phenotype0.41327222
94MP0004019_abnormal_vitamin_homeostasis0.41140830
95MP0005376_homeostasis/metabolism_phenot0.40823815
96MP0001501_abnormal_sleep_pattern0.37225265
97MP0000470_abnormal_stomach_morphology0.37015784
98MP0010307_abnormal_tumor_latency0.36724941
99MP0001243_abnormal_dermal_layer0.36476997
100MP0009046_muscle_twitch0.36141597

Predicted human phenotypes

RankGene SetZ-score
1Nasal polyposis (HP:0100582)8.43832232
2Abnormality of the nasal mucosa (HP:0000433)7.12029637
3Chronic otitis media (HP:0000389)6.25542954
4Elevated erythrocyte sedimentation rate (HP:0003565)6.08428037
5Brushfield spots (HP:0001088)5.95691693
6Autoimmune thrombocytopenia (HP:0001973)4.84474089
7Recurrent bronchitis (HP:0002837)4.60589996
8Autoimmune hemolytic anemia (HP:0001890)4.55666620
9Increased IgM level (HP:0003496)4.51612313
10Delayed closure of the anterior fontanelle (HP:0001476)4.48721811
11Flat occiput (HP:0005469)4.35901161
12Muscle fiber atrophy (HP:0100295)4.16508664
13Chronic sinusitis (HP:0011109)4.16307375
14Stomatitis (HP:0010280)4.06930194
15Chronic mucocutaneous candidiasis (HP:0002728)3.90431648
16Recurrent cutaneous fungal infections (HP:0011370)3.90431648
17Hypergammaglobulinemia (HP:0010702)3.81533835
18Abnormality of T cell number (HP:0011839)3.80559349
19Aplastic anemia (HP:0001915)3.70908283
20Recurrent fungal infections (HP:0002841)3.57385091
21Keratoconjunctivitis (HP:0001096)3.56502026
22Large eyes (HP:0001090)3.52710817
23Pustule (HP:0200039)3.49064840
24Achilles tendon contracture (HP:0001771)3.48733647
25Flat capital femoral epiphysis (HP:0003370)3.48487287
26Abnormality of B cell number (HP:0010975)3.45102421
27Abnormality of the Achilles tendon (HP:0005109)3.20115618
28Asplenia (HP:0001746)3.17962883
29Hemiplegia (HP:0002301)3.10019063
30Shawl scrotum (HP:0000049)3.10012592
31Reduced subcutaneous adipose tissue (HP:0003758)3.08819655
32Abnormality of T cells (HP:0002843)3.04064756
33Chronic diarrhea (HP:0002028)3.00777850
34Abnormality of macrophages (HP:0004311)2.98201373
35Hypoproteinemia (HP:0003075)2.96156173
36Abnormality of the fingertips (HP:0001211)2.89510103
37Aplasia/Hypoplasia of the spleen (HP:0010451)2.87786570
38Severe visual impairment (HP:0001141)2.85656749
39Abnormal delayed hypersensitivity skin test (HP:0002963)2.84556050
40T lymphocytopenia (HP:0005403)2.80709418
41Eosinophilia (HP:0001880)2.79371069
42Epiphyseal stippling (HP:0010655)2.78187741
43Primary adrenal insufficiency (HP:0008207)2.75589939
44Atrioventricular block (HP:0001678)2.72746596
45Abnormality of T cell physiology (HP:0011840)2.63903020
46Decreased electroretinogram (ERG) amplitude (HP:0000654)2.61452440
47Bronchitis (HP:0012387)2.59484674
48Oral leukoplakia (HP:0002745)2.58406651
49Agammaglobulinemia (HP:0004432)2.56162096
50Thickened nuchal skin fold (HP:0000474)2.54599461
51Spinal cord lesions (HP:0100561)2.49353213
52Syringomyelia (HP:0003396)2.49353213
53Emphysema (HP:0002097)2.49220741
54Hypertriglyceridemia (HP:0002155)2.47852401
55Stomach cancer (HP:0012126)2.43309360
56Abnormality of eosinophils (HP:0001879)2.41663964
57Basal ganglia calcification (HP:0002135)2.39386245
58Esophageal atresia (HP:0002032)2.36470052
59Increased IgE level (HP:0003212)2.35889914
60Erythema (HP:0010783)2.34792526
61Granulocytopenia (HP:0001913)2.33807673
62Encephalitis (HP:0002383)2.33761365
63Female pseudohermaphroditism (HP:0010458)2.30592428
64Joint swelling (HP:0001386)2.28701293
65Posterior embryotoxon (HP:0000627)2.28549227
66Meningitis (HP:0001287)2.27783421
67Abnormality of the line of Schwalbe (HP:0008048)2.23670952
68Abnormality of calcium-phosphate metabolism (HP:0100530)2.22205430
69Lymphoma (HP:0002665)2.21807131
70Recurrent skin infections (HP:0001581)2.21214972
71Abnormality of macular pigmentation (HP:0008002)2.19309694
72Abnormality of cells of the lymphoid lineage (HP:0012140)2.16823088
73Underdeveloped supraorbital ridges (HP:0009891)2.10209289
74Leukocytosis (HP:0001974)2.07388762
75Xanthomatosis (HP:0000991)2.06590915
76Joint contractures involving the joints of the feet (HP:0100492)2.05771779
77Flexion contracture of toe (HP:0005830)2.05771779
78Large earlobe (HP:0009748)2.02206443
79Hypoparathyroidism (HP:0000829)2.01062517
80Vasculitis (HP:0002633)1.96692838
81Large for gestational age (HP:0001520)1.93323206
82Delayed cranial suture closure (HP:0000270)1.86985200
83Abnormal epiphyseal ossification (HP:0010656)1.86440898
84Agnosia (HP:0010524)1.82531979
85Increased CSF protein (HP:0002922)1.82318392
86Prominent nose (HP:0000448)1.78643517
87Beaking of vertebral bodies (HP:0004568)1.77252674
88Abnormality of glycolipid metabolism (HP:0010969)1.77075901
89Abnormality of liposaccharide metabolism (HP:0010968)1.77075901
90Abnormality of glycosphingolipid metabolism (HP:0004343)1.77075901
91Hypochromic anemia (HP:0001931)1.76353422
92Alopecia of scalp (HP:0002293)1.75861660
93Lymphopenia (HP:0001888)1.74682010
94Rib fusion (HP:0000902)1.73633589
95Hypercortisolism (HP:0001578)1.73505131
96Submucous cleft hard palate (HP:0000176)1.73200291
97Elbow flexion contracture (HP:0002987)1.72985604
98Recurrent viral infections (HP:0004429)1.70904672
99Patchy hypopigmentation of hair (HP:0011365)1.70441466
100Abnormality of binocular vision (HP:0011514)1.69366563

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PASK5.99892583
2MAP3K135.39305242
3IRAK44.30221626
4AKT34.02914520
5GRK74.02137119
6ITK3.15830009
7TGFBR23.15190612
8MOS2.97390427
9MAP3K142.85867988
10STK102.72280206
11TAF12.69312984
12FGR2.36312687
13TXK2.34567785
14CAMKK12.33254918
15PIK3CG1.97050118
16CSK1.88497863
17PTK21.85674958
18KDR1.84739817
19ILK1.69036104
20GRK51.68507073
21KIT1.57598961
22MARK31.46147514
23TESK21.42276827
24MAP3K111.37412898
25JAK11.34446009
26SYK1.31115413
27LRRK21.25993984
28MAP4K11.22181308
29IKBKB1.14485085
30LCK0.96319748
31BTK0.91345139
32TYK20.90492036
33HCK0.89635311
34BRAF0.87917728
35PIM10.85138512
36PRKCQ0.84671221
37LYN0.80952758
38ADRBK20.78192906
39IKBKE0.77622206
40ERN10.73777558
41FES0.70896562
42MAP3K70.70255901
43GSK3A0.70194849
44MAP3K120.69781881
45MAPK120.68076664
46RIPK10.62724696
47EIF2AK20.60654305
48PKN10.59539889
49PIK3CA0.59287202
50MAP3K100.57148013
51PDK10.56964834
52SGK20.55592889
53HIPK20.53634957
54MATK0.51723832
55JAK20.50575552
56RIPK40.50201162
57BCKDK0.49785157
58MAP2K60.49173194
59BLK0.46165946
60TBK10.45407030
61EPHB10.44687224
62ABL10.43981068
63FGFR10.42540183
64CHUK0.42367260
65AURKA0.40482308
66TNK20.38694153
67PAK10.38185201
68MAPKAPK20.37073271
69ADRBK10.37038827
70CDK40.36260819
71CLK10.35373740
72INSRR0.33544684
73JAK30.32659032
74SRC0.31545724
75MAPK70.31516086
76PRKCD0.31496514
77FYN0.31349165
78TEC0.31131994
79SGK30.30346236
80MAPKAPK30.29890132
81PRKCI0.27629236
82MAP2K30.26991524
83OBSCN0.25678228
84FRK0.23360449
85MAPK130.22395993
86PRKACA0.22215846
87BMPR20.21183171
88EPHA30.20863957
89NUAK10.20335085
90SGK4940.19385045
91SGK2230.19385045
92GRK60.19317899
93KSR10.18556927
94MAP2K40.17853836
95TAOK30.17376520
96CSF1R0.17137861
97INSR0.16728807
98NLK0.16296747
99MAP4K20.15985355
100NME20.14580427

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053324.71321022
2Primary immunodeficiency_Homo sapiens_hsa053404.38258505
3Autoimmune thyroid disease_Homo sapiens_hsa053203.95063669
4Allograft rejection_Homo sapiens_hsa053303.93971064
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.28463488
6Antigen processing and presentation_Homo sapiens_hsa046123.19728293
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.18100565
8Type I diabetes mellitus_Homo sapiens_hsa049403.13801779
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.44773086
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.17187514
11Viral myocarditis_Homo sapiens_hsa054162.01563293
12Asthma_Homo sapiens_hsa053101.86006306
13Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.81905462
14Rheumatoid arthritis_Homo sapiens_hsa053231.67798836
15Leishmaniasis_Homo sapiens_hsa051401.67179374
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.64314957
17Hematopoietic cell lineage_Homo sapiens_hsa046401.60889129
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.60561319
19B cell receptor signaling pathway_Homo sapiens_hsa046621.47602563
20Staphylococcus aureus infection_Homo sapiens_hsa051501.43481721
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.43386742
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.42314121
23Chemokine signaling pathway_Homo sapiens_hsa040621.37073777
24Malaria_Homo sapiens_hsa051441.34859089
25T cell receptor signaling pathway_Homo sapiens_hsa046601.30953717
26Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.30705782
27Salmonella infection_Homo sapiens_hsa051321.29395889
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.26159175
29Herpes simplex infection_Homo sapiens_hsa051681.25753593
30Regulation of autophagy_Homo sapiens_hsa041401.23581544
31Measles_Homo sapiens_hsa051621.23435254
32Tuberculosis_Homo sapiens_hsa051521.22660880
33Osteoclast differentiation_Homo sapiens_hsa043801.19252084
34Sulfur metabolism_Homo sapiens_hsa009201.14707021
35Mineral absorption_Homo sapiens_hsa049781.11939402
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.11191967
37ABC transporters_Homo sapiens_hsa020101.10548682
38Pertussis_Homo sapiens_hsa051331.06096843
39Fatty acid elongation_Homo sapiens_hsa000621.05374355
40Legionellosis_Homo sapiens_hsa051341.04600321
41Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.03925505
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.03324748
43Proteasome_Homo sapiens_hsa030501.00646138
44Dilated cardiomyopathy_Homo sapiens_hsa054140.93044542
45TNF signaling pathway_Homo sapiens_hsa046680.92939366
46Toxoplasmosis_Homo sapiens_hsa051450.89982303
47Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.89903086
48African trypanosomiasis_Homo sapiens_hsa051430.83996614
49Phototransduction_Homo sapiens_hsa047440.81586685
50Phagosome_Homo sapiens_hsa041450.80107184
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.78845034
52Influenza A_Homo sapiens_hsa051640.76380457
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74722419
54Peroxisome_Homo sapiens_hsa041460.73522698
55Apoptosis_Homo sapiens_hsa042100.72973145
56Systemic lupus erythematosus_Homo sapiens_hsa053220.70291817
57Vitamin digestion and absorption_Homo sapiens_hsa049770.70079758
58Epstein-Barr virus infection_Homo sapiens_hsa051690.67482656
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64994180
60Tyrosine metabolism_Homo sapiens_hsa003500.64107261
61Cardiac muscle contraction_Homo sapiens_hsa042600.63601994
62Acute myeloid leukemia_Homo sapiens_hsa052210.59730705
63Oxidative phosphorylation_Homo sapiens_hsa001900.56832520
64Retinol metabolism_Homo sapiens_hsa008300.49566932
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47261998
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.41296875
67Hepatitis B_Homo sapiens_hsa051610.41249736
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40435617
69Complement and coagulation cascades_Homo sapiens_hsa046100.40013842
70cAMP signaling pathway_Homo sapiens_hsa040240.39209265
71Dorso-ventral axis formation_Homo sapiens_hsa043200.38832170
72Alzheimers disease_Homo sapiens_hsa050100.34408556
73Shigellosis_Homo sapiens_hsa051310.32661854
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31968636
75Hepatitis C_Homo sapiens_hsa051600.31593288
76Parkinsons disease_Homo sapiens_hsa050120.30607183
77Type II diabetes mellitus_Homo sapiens_hsa049300.30461948
78Histidine metabolism_Homo sapiens_hsa003400.29711161
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29591944
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29210956
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28623857
82HTLV-I infection_Homo sapiens_hsa051660.28480367
83Salivary secretion_Homo sapiens_hsa049700.27670744
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.26836150
85Ribosome_Homo sapiens_hsa030100.24782616
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.22230919
87RNA degradation_Homo sapiens_hsa030180.20311911
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.19382010
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.18507036
90Platelet activation_Homo sapiens_hsa046110.17364750
91Sulfur relay system_Homo sapiens_hsa041220.16303212
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.16266704
93Huntingtons disease_Homo sapiens_hsa050160.16202012
94Chemical carcinogenesis_Homo sapiens_hsa052040.14955730
95Olfactory transduction_Homo sapiens_hsa047400.14904679
96Endocytosis_Homo sapiens_hsa041440.14362494
97Gastric acid secretion_Homo sapiens_hsa049710.12003061
98FoxO signaling pathway_Homo sapiens_hsa040680.11863046
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.11294273
100Amoebiasis_Homo sapiens_hsa051460.10960313

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