LACTB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.35818215
2L-phenylalanine catabolic process (GO:0006559)7.35818215
3L-phenylalanine metabolic process (GO:0006558)7.12772450
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.12772450
5aromatic amino acid family catabolic process (GO:0009074)6.89315698
6indole-containing compound catabolic process (GO:0042436)6.47751780
7indolalkylamine catabolic process (GO:0046218)6.47751780
8tryptophan catabolic process (GO:0006569)6.47751780
9glyoxylate metabolic process (GO:0046487)6.37041919
10cysteine metabolic process (GO:0006534)6.14551375
11tryptophan metabolic process (GO:0006568)6.10976890
12kynurenine metabolic process (GO:0070189)6.00822416
13lysine catabolic process (GO:0006554)5.99450868
14lysine metabolic process (GO:0006553)5.99450868
15bile acid biosynthetic process (GO:0006699)5.65989624
16serine family amino acid catabolic process (GO:0009071)5.55317559
17urate metabolic process (GO:0046415)5.52546147
18fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.42670246
19homocysteine metabolic process (GO:0050667)5.36040278
20sulfur amino acid catabolic process (GO:0000098)5.27881009
21drug transmembrane transport (GO:0006855)5.23850299
22mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.17761709
23triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.15467737
24alpha-linolenic acid metabolic process (GO:0036109)5.11776804
25urea metabolic process (GO:0019627)5.11646583
26urea cycle (GO:0000050)5.11646583
27aromatic amino acid family metabolic process (GO:0009072)5.07807133
28amino-acid betaine metabolic process (GO:0006577)5.00774470
29serine family amino acid metabolic process (GO:0009069)4.80740305
30alpha-amino acid catabolic process (GO:1901606)4.80626096
31nitrogen cycle metabolic process (GO:0071941)4.75754910
32bile acid metabolic process (GO:0008206)4.75348979
33drug catabolic process (GO:0042737)4.71636718
34proteasome assembly (GO:0043248)4.65978803
35indolalkylamine metabolic process (GO:0006586)4.58484683
36mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.57454795
37protein carboxylation (GO:0018214)4.57395649
38peptidyl-glutamic acid carboxylation (GO:0017187)4.57395649
39complement activation, alternative pathway (GO:0006957)4.55873214
40negative regulation of fibrinolysis (GO:0051918)4.54104327
41glycine metabolic process (GO:0006544)4.53247802
42cellular amino acid catabolic process (GO:0009063)4.52252979
43regulation of protein activation cascade (GO:2000257)4.50556402
44tyrosine metabolic process (GO:0006570)4.49721744
45amine catabolic process (GO:0009310)4.48563525
46cellular biogenic amine catabolic process (GO:0042402)4.48563525
47cellular modified amino acid catabolic process (GO:0042219)4.47198793
48serine family amino acid biosynthetic process (GO:0009070)4.47007098
49high-density lipoprotein particle remodeling (GO:0034375)4.45653653
50cellular ketone body metabolic process (GO:0046950)4.44554036
51drug transport (GO:0015893)4.39979001
52short-chain fatty acid metabolic process (GO:0046459)4.38433083
53regulation of fibrinolysis (GO:0051917)4.35701777
54rRNA modification (GO:0000154)4.30781654
55glutamate metabolic process (GO:0006536)4.30164108
56exogenous drug catabolic process (GO:0042738)4.27321644
57cellular glucuronidation (GO:0052695)4.26309431
58benzene-containing compound metabolic process (GO:0042537)4.25938767
59regulation of complement activation (GO:0030449)4.24145303
60aspartate family amino acid catabolic process (GO:0009068)4.21272520
61acetyl-CoA metabolic process (GO:0006084)4.16886346
62coenzyme catabolic process (GO:0009109)4.16182356
63energy coupled proton transport, down electrochemical gradient (GO:0015985)4.11529760
64ATP synthesis coupled proton transport (GO:0015986)4.11529760
65regulation of triglyceride catabolic process (GO:0010896)4.08258269
66negative regulation of sterol transport (GO:0032372)4.06535422
67negative regulation of cholesterol transport (GO:0032375)4.06535422
68ethanol oxidation (GO:0006069)4.05058301
69triglyceride homeostasis (GO:0070328)4.04507282
70acylglycerol homeostasis (GO:0055090)4.04507282
71organic acid catabolic process (GO:0016054)4.01231602
72carboxylic acid catabolic process (GO:0046395)4.01231602
73respiratory electron transport chain (GO:0022904)4.01095200
74aldehyde catabolic process (GO:0046185)4.01088393
752-oxoglutarate metabolic process (GO:0006103)3.99343120
76valine metabolic process (GO:0006573)3.96749679
77fatty acid beta-oxidation (GO:0006635)3.96167355
78rRNA methylation (GO:0031167)3.95697416
79dicarboxylic acid biosynthetic process (GO:0043650)3.95082842
80bile acid and bile salt transport (GO:0015721)3.94313959
81regulation of cholesterol esterification (GO:0010872)3.92812497
82pteridine-containing compound biosynthetic process (GO:0042559)3.92341623
83electron transport chain (GO:0022900)3.90943231
84fatty acid oxidation (GO:0019395)3.90247715
85uronic acid metabolic process (GO:0006063)3.89696954
86glucuronate metabolic process (GO:0019585)3.89696954
87establishment of protein localization to mitochondrial membrane (GO:0090151)3.88539439
88reverse cholesterol transport (GO:0043691)3.85722458
89protein-lipid complex remodeling (GO:0034368)3.85500820
90macromolecular complex remodeling (GO:0034367)3.85500820
91plasma lipoprotein particle remodeling (GO:0034369)3.85500820
92imidazole-containing compound metabolic process (GO:0052803)3.84351423
93ketone body metabolic process (GO:1902224)3.84067288
94lipid oxidation (GO:0034440)3.82905016
95carnitine metabolic process (GO:0009437)3.81063639
96respiratory chain complex IV assembly (GO:0008535)3.77760959
97negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.75838384
98chaperone-mediated protein transport (GO:0072321)3.74874008
99monocarboxylic acid catabolic process (GO:0072329)3.70888977
100branched-chain amino acid metabolic process (GO:0009081)3.70610883
101branched-chain amino acid catabolic process (GO:0009083)3.67988706
102fatty acid catabolic process (GO:0009062)3.67088599
103phospholipid efflux (GO:0033700)3.66689532
104positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.66081626
105regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.65425839
106water-soluble vitamin biosynthetic process (GO:0042364)3.65109521
107arginine metabolic process (GO:0006525)3.64880431
108ribosome assembly (GO:0042255)3.63586162
109regulation of cholesterol homeostasis (GO:2000188)3.63352063
110plasma lipoprotein particle clearance (GO:0034381)3.63179223
111regulation of mitochondrial translation (GO:0070129)3.62430635
112response to mercury ion (GO:0046689)3.60632015
113transcription from mitochondrial promoter (GO:0006390)3.60583879
114pyridine nucleotide biosynthetic process (GO:0019363)3.59932231
115nicotinamide nucleotide biosynthetic process (GO:0019359)3.59932231
116mitochondrial respiratory chain complex assembly (GO:0033108)3.58688682
117regulation of bile acid biosynthetic process (GO:0070857)3.58161480
118regulation of cellular amino acid metabolic process (GO:0006521)3.56855212
119CENP-A containing nucleosome assembly (GO:0034080)3.56533692
120drug metabolic process (GO:0017144)3.56116519
121NAD biosynthetic process (GO:0009435)3.54512931
122phospholipid homeostasis (GO:0055091)3.53146264
123protein complex biogenesis (GO:0070271)3.52320145
124flavonoid metabolic process (GO:0009812)3.47800569
125chromatin remodeling at centromere (GO:0031055)3.47581955
126anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.43084512
127purine nucleobase biosynthetic process (GO:0009113)3.42731465
128folic acid-containing compound biosynthetic process (GO:0009396)3.41453264
129cytochrome complex assembly (GO:0017004)3.41281700
130ribosomal large subunit biogenesis (GO:0042273)3.40808703
131negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.39764490
132negative regulation of ligase activity (GO:0051352)3.39764490
133DNA replication checkpoint (GO:0000076)3.34181925
134tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.32584597
135RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.32584597
136establishment of integrated proviral latency (GO:0075713)3.28447448
137pseudouridine synthesis (GO:0001522)3.24736913
138mitochondrial RNA metabolic process (GO:0000959)3.21272876
139positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.19489672
140protein neddylation (GO:0045116)3.18816982
141cullin deneddylation (GO:0010388)3.18252042
142nucleobase biosynthetic process (GO:0046112)3.17599373
143protein K6-linked ubiquitination (GO:0085020)3.13104382
144mitotic metaphase plate congression (GO:0007080)3.11155468
145DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.10950614
146positive regulation of ligase activity (GO:0051351)3.10242138
147intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.06926874
148signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.06926874
149mitochondrial respiratory chain complex I assembly (GO:0032981)3.06851180
150NADH dehydrogenase complex assembly (GO:0010257)3.06851180
151mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.06851180
152protein targeting to mitochondrion (GO:0006626)3.06511609
153signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.06225784
154signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.06225784
155signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.06225784
156tetrahydrofolate metabolic process (GO:0046653)3.00957883
157signal transduction involved in DNA integrity checkpoint (GO:0072401)2.98230989
158signal transduction involved in DNA damage checkpoint (GO:0072422)2.98230989
159histone exchange (GO:0043486)2.93922959
160signal transduction involved in cell cycle checkpoint (GO:0072395)2.91302271
161translation (GO:0006412)2.90231401
162metaphase plate congression (GO:0051310)2.90193656
163formation of translation preinitiation complex (GO:0001731)2.89415141
164protein deneddylation (GO:0000338)2.87103082
165xenobiotic catabolic process (GO:0042178)2.86527328
166oxidative phosphorylation (GO:0006119)2.86216345
167telomere maintenance via semi-conservative replication (GO:0032201)2.84588071
168regulation of ubiquitin-protein transferase activity (GO:0051438)2.83887715
169kinetochore organization (GO:0051383)2.83413542
170cellular component biogenesis (GO:0044085)2.82869275
171rRNA processing (GO:0006364)2.82814675
172protein localization to mitochondrion (GO:0070585)2.80795825
173tricarboxylic acid cycle (GO:0006099)2.79864095
174pteridine-containing compound metabolic process (GO:0042558)2.79821764
175daunorubicin metabolic process (GO:0044597)2.78919161
176polyketide metabolic process (GO:0030638)2.78919161
177doxorubicin metabolic process (GO:0044598)2.78919161
178regulation of ligase activity (GO:0051340)2.77686633
179IMP biosynthetic process (GO:0006188)2.76258066
180peptidyl-histidine modification (GO:0018202)2.75779621
181exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.74970272
182nucleobase-containing small molecule interconversion (GO:0015949)2.74824603
183establishment of protein localization to mitochondrion (GO:0072655)2.74700693
184aminoglycoside antibiotic metabolic process (GO:0030647)2.73500896
185ribonucleoprotein complex biogenesis (GO:0022613)2.73396610
186lactate metabolic process (GO:0006089)2.72348922
187L-methionine salvage (GO:0071267)2.72244683
188L-methionine biosynthetic process (GO:0071265)2.72244683
189amino acid salvage (GO:0043102)2.72244683
190termination of RNA polymerase III transcription (GO:0006386)2.72086086
191transcription elongation from RNA polymerase III promoter (GO:0006385)2.72086086
192dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.71264891
193rRNA metabolic process (GO:0016072)2.69768858
194L-serine metabolic process (GO:0006563)2.69214313
195DNA strand elongation involved in DNA replication (GO:0006271)2.68508665

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.18458910
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.09331557
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.76119330
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.24455137
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.32068122
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.12554536
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.84023160
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.82411627
9GABP_17652178_ChIP-ChIP_JURKAT_Human4.39123200
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.06140012
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.80956132
12E2F7_22180533_ChIP-Seq_HELA_Human3.76401259
13EST1_17652178_ChIP-ChIP_JURKAT_Human3.66973029
14* MYC_18555785_ChIP-Seq_MESCs_Mouse3.18592125
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.18474183
16CREB1_15753290_ChIP-ChIP_HEK293T_Human3.06695695
17ELK1_19687146_ChIP-ChIP_HELA_Human3.00986882
18E2F4_17652178_ChIP-ChIP_JURKAT_Human3.00430688
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.79152608
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.76003403
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.55928935
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.50196139
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.47310089
24HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.46287506
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.45405820
26VDR_23849224_ChIP-Seq_CD4+_Human2.33769462
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.33661145
28* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.28143426
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.24421084
30* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.19839249
31FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.15739215
32DCP1A_22483619_ChIP-Seq_HELA_Human2.14351061
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.11253676
34TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.08577315
35FOXP3_21729870_ChIP-Seq_TREG_Human2.08391407
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.07704553
37ELF1_17652178_ChIP-ChIP_JURKAT_Human2.07294467
38PADI4_21655091_ChIP-ChIP_MCF-7_Human2.06798136
39* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.04999695
40ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.4340585
41MYC_19079543_ChIP-ChIP_MESCs_Mouse1.99024114
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.97834238
43NELFA_20434984_ChIP-Seq_ESCs_Mouse1.88307820
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.82987841
45FOXM1_23109430_ChIP-Seq_U2OS_Human1.70685889
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69623334
47CLOCK_20551151_ChIP-Seq_293T_Human1.67912253
48GABP_19822575_ChIP-Seq_HepG2_Human1.65445873
49STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.64161942
50SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.61301578
51* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.61094114
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.58996791
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.57705693
54TTF2_22483619_ChIP-Seq_HELA_Human1.57434759
55GATA1_22025678_ChIP-Seq_K562_Human1.54047830
56* HNF4A_19822575_ChIP-Seq_HepG2_Human1.52280970
57YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48909415
58FOXA2_19822575_ChIP-Seq_HepG2_Human1.48247429
59KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.43753132
60XRN2_22483619_ChIP-Seq_HELA_Human1.41946742
61* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.39657895
62ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.35977562
63ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34405664
64ELK1_22589737_ChIP-Seq_MCF10A_Human1.33334481
65* TFEB_21752829_ChIP-Seq_HELA_Human1.33256343
66POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.30902476
67MYC_18940864_ChIP-ChIP_HL60_Human1.22722991
68IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.22686929
69EWS_26573619_Chip-Seq_HEK293_Human1.19735338
70IRF8_22096565_ChIP-ChIP_GC-B_Human1.19554178
71TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.19245561
72RXRA_24833708_ChIP-Seq_LIVER_Mouse1.18817826
73MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.17099300
74STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15923763
75HTT_18923047_ChIP-ChIP_STHdh_Human1.15151773
76RARG_19884340_ChIP-ChIP_MEFs_Mouse1.13557828
77CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.13298081
78KDM5A_27292631_Chip-Seq_BREAST_Human1.12329260
79FUS_26573619_Chip-Seq_HEK293_Human1.12032243
80ESR1_21235772_ChIP-Seq_MCF-7_Human1.11657097
81POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10352897
82E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.10296621
83VDR_22108803_ChIP-Seq_LS180_Human1.10261117
84ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10254382
85SOX17_20123909_ChIP-Seq_XEN_Mouse1.10221534
86SOX2_27498859_Chip-Seq_STOMACH_Mouse1.10178139
87ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08263571
88SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07421803
89ELF5_23300383_ChIP-Seq_T47D_Human1.06494579
90RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05188033
91* FLI1_27457419_Chip-Seq_LIVER_Mouse1.04467310
92ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.03284562
93NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03049294
94* GATA4_25053715_ChIP-Seq_YYC3_Human1.02878762
95POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02856283
96MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.01813324
97SALL1_21062744_ChIP-ChIP_HESCs_Human1.00374942
98KAP1_22055183_ChIP-Seq_ESCs_Mouse1.00249081
99E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00049633
100BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00004111
101PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90206785
102NANOG_16153702_ChIP-ChIP_HESCs_Human0.85261210
103SALL4_18804426_ChIP-ChIP_XEN_Mouse0.83654523
104RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.83410400
105* NANOG_18555785_ChIP-Seq_MESCs_Mouse0.82845556
106CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.82572433
107Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.82341795
108PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.82089312
109STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.82086010
110CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.81146676
111YY1_21170310_ChIP-Seq_MESCs_Mouse0.80305916
112SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.77778232
113ESR2_21235772_ChIP-Seq_MCF-7_Human0.77560993
114ESR1_15608294_ChIP-ChIP_MCF-7_Human0.77184144
115NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.77178705
116EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.76577001
117* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.76503243
118* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.76418263
119SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.76317171
120AR_21909140_ChIP-Seq_LNCAP_Human0.76231280
121* PCGF2_27294783_Chip-Seq_ESCs_Mouse0.75961464
122AUTS2_25519132_ChIP-Seq_293T-REX_Human0.75447918
123RARA_24833708_ChIP-Seq_LIVER_Mouse0.72998091
124* EZH2_27294783_Chip-Seq_NPCs_Mouse0.71678573
125CDX2_20551321_ChIP-Seq_CACO-2_Human0.70962930
126FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.69227675
127FOXA1_27270436_Chip-Seq_PROSTATE_Human0.69167591
128FOXA1_25329375_ChIP-Seq_VCAP_Human0.69167591
129* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.68866164
130THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.68516480
131BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.67435529
132PHF8_20622853_ChIP-Seq_HELA_Human0.67227167
133FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.66015979
134CEBPB_22108803_ChIP-Seq_LS180_Human0.63979563
135GATA6_25053715_ChIP-Seq_YYC3_Human0.63567301
136ZNF263_19887448_ChIP-Seq_K562_Human0.62750705
137* AR_20517297_ChIP-Seq_VCAP_Human0.61300368
138* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.59476400
139EGR1_19032775_ChIP-ChIP_M12_Human0.59132786
140* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.58905492
141RARB_24833708_ChIP-Seq_LIVER_Mouse0.58636872
142RAD21_21589869_ChIP-Seq_MESCs_Mouse0.58306682
143BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.56230711
144* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.56209779
145ESET_19884257_ChIP-Seq_ESCs_Mouse0.55355065
146FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.54849829
147* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.53678978
148NRF2_20460467_ChIP-Seq_MEFs_Mouse0.52994929
149NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.52994929
150STAT1_17558387_ChIP-Seq_HELA_Human0.52640353
151ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.51613440
152PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.51231518
153MYC_19915707_ChIP-ChIP_AK7_Human0.51134351
154PPAR_26484153_Chip-Seq_NCI-H1993_Human0.50331408
155PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.50280861
156FOXO3_23340844_ChIP-Seq_DLD1_Human0.50139859
157SOX2_18692474_ChIP-Seq_MEFs_Mouse0.49347030
158CBP_21632823_ChIP-Seq_H3396_Human0.48666535
159TCF3_18692474_ChIP-Seq_MEFs_Mouse0.47317120
160CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.46282254
161CDX2_22108803_ChIP-Seq_LS180_Human0.45993594
162FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.45747217
163FOXA1_25552417_ChIP-Seq_VCAP_Human0.45113942
164GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.44655896
165TAF2_19829295_ChIP-Seq_ESCs_Human0.44459338
166NANOG_16518401_ChIP-PET_MESCs_Mouse0.43404454
167GATA3_24758297_ChIP-Seq_MCF-7_Human0.42749106
168NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.42571096
169* SRF_21415370_ChIP-Seq_HL-1_Mouse0.42557228
170IRF1_19129219_ChIP-ChIP_H3396_Human0.40964902
171GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.40516557
172CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.40259346
173PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.38769629
174* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.38118347
175* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.37888561
176RAC3_21632823_ChIP-Seq_H3396_Human0.37742674
177LXR_22292898_ChIP-Seq_THP-1_Human0.37729893
178ERG_20517297_ChIP-Seq_VCAP_Human0.37488681
179FOXH1_21741376_ChIP-Seq_EPCs_Human0.37041998
180STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.36968829

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.00872269
2MP0005360_urolithiasis7.96819678
3MP0005085_abnormal_gallbladder_physiolo5.88453585
4MP0005365_abnormal_bile_salt5.72870922
5MP0008875_abnormal_xenobiotic_pharmacok4.76215623
6MP0003806_abnormal_nucleotide_metabolis4.19603367
7MP0003252_abnormal_bile_duct3.85226267
8MP0005332_abnormal_amino_acid3.47053398
9MP0008058_abnormal_DNA_repair3.34448987
10MP0003195_calcinosis3.24779314
11MP0010094_abnormal_chromosome_stability3.23350207
12MP0003693_abnormal_embryo_hatching3.08838555
13MP0010329_abnormal_lipoprotein_level3.07898330
14MP0004019_abnormal_vitamin_homeostasis2.96455409
15MP0004957_abnormal_blastocyst_morpholog2.95859399
16MP0010234_abnormal_vibrissa_follicle2.88013730
17MP0009840_abnormal_foam_cell2.69621348
18MP0002138_abnormal_hepatobiliary_system2.59949789
19MP0005083_abnormal_biliary_tract2.52667274
20MP0003941_abnormal_skin_development2.44941891
21MP0003111_abnormal_nucleus_morphology2.43520739
22MP0008057_abnormal_DNA_replication2.41117593
23MP0001666_abnormal_nutrient_absorption2.39606784
24MP0002938_white_spotting2.27439997
25MP0003077_abnormal_cell_cycle2.26228924
26MP0003191_abnormal_cellular_cholesterol2.04821035
27MP0009643_abnormal_urine_homeostasis2.01470360
28MP0003786_premature_aging1.98734340
29MP0008007_abnormal_cellular_replicative1.96269080
30* MP0000609_abnormal_liver_physiology1.95900588
31MP0002118_abnormal_lipid_homeostasis1.94482378
32MP0005319_abnormal_enzyme/_coenzyme1.91075155
33MP0008932_abnormal_embryonic_tissue1.90823355
34MP0001764_abnormal_homeostasis1.73806236
35MP0003186_abnormal_redox_activity1.73153994
36MP0003950_abnormal_plasma_membrane1.68647333
37MP0002837_dystrophic_cardiac_calcinosis1.66054558
38MP0005584_abnormal_enzyme/coenzyme_acti1.63969760
39MP0004043_abnormal_pH_regulation1.59685821
40MP0000372_irregular_coat_pigmentation1.52371390
41MP0003868_abnormal_feces_composition1.51005895
42MP0005636_abnormal_mineral_homeostasis1.47068485
43MP0005451_abnormal_body_composition1.40968344
44MP0009697_abnormal_copulation1.40061928
45MP0000358_abnormal_cell_content/1.31472602
46MP0005670_abnormal_white_adipose1.25894105
47MP0001756_abnormal_urination1.24280540
48MP0006072_abnormal_retinal_apoptosis1.22419497
49MP0002090_abnormal_vision1.15702429
50* MP0000598_abnormal_liver_morphology1.12380503
51MP0006036_abnormal_mitochondrial_physio1.12181409
52MP0004215_abnormal_myocardial_fiber1.11918020
53MP0002136_abnormal_kidney_physiology1.11421502
54MP0009764_decreased_sensitivity_to1.09577971
55MP0002638_abnormal_pupillary_reflex1.07475486
56MP0002160_abnormal_reproductive_system1.06763277
57MP0001697_abnormal_embryo_size1.04990306
58MP0005084_abnormal_gallbladder_morpholo1.04112146
59MP0002876_abnormal_thyroid_physiology1.02061487
60MP0005379_endocrine/exocrine_gland_phen1.01034998
61MP0005647_abnormal_sex_gland1.00403982
62MP0008877_abnormal_DNA_methylation0.99246304
63MP0005330_cardiomyopathy0.97696621
64MP0010307_abnormal_tumor_latency0.97689735
65MP0003011_delayed_dark_adaptation0.97497720
66MP0003705_abnormal_hypodermis_morpholog0.97285135
67MP0001730_embryonic_growth_arrest0.96641630
68MP0003656_abnormal_erythrocyte_physiolo0.95041911
69MP0008469_abnormal_protein_level0.93912037
70MP0001765_abnormal_ion_homeostasis0.91944325
71MP0010352_gastrointestinal_tract_polyps0.90852812
72MP0009763_increased_sensitivity_to0.90812697
73MP0000647_abnormal_sebaceous_gland0.89868278
74MP0009642_abnormal_blood_homeostasis0.89666993
75MP0000350_abnormal_cell_proliferation0.88878226
76MP0005408_hypopigmentation0.87484320
77MP0001929_abnormal_gametogenesis0.84661663
78MP0001661_extended_life_span0.84473314
79MP0001529_abnormal_vocalization0.83425300
80MP0005389_reproductive_system_phenotype0.83359541
81MP0003123_paternal_imprinting0.80771026
82MP0005058_abnormal_lysosome_morphology0.80451900
83MP0005220_abnormal_exocrine_pancreas0.80359686
84MP0001727_abnormal_embryo_implantation0.77427713
85MP0002102_abnormal_ear_morphology0.77104146
86MP0005535_abnormal_body_temperature0.76850825
87MP0002210_abnormal_sex_determination0.76715629
88MP0006292_abnormal_olfactory_placode0.76304749
89MP0005376_homeostasis/metabolism_phenot0.75335060
90MP0002078_abnormal_glucose_homeostasis0.74627991
91MP0005646_abnormal_pituitary_gland0.74444790
92MP0005410_abnormal_fertilization0.74200572
93MP0010678_abnormal_skin_adnexa0.74052203
94MP0000427_abnormal_hair_cycle0.74032415
95MP0002254_reproductive_system_inflammat0.73737751
96MP0001944_abnormal_pancreas_morphology0.73110885
97MP0006035_abnormal_mitochondrial_morpho0.72960923
98MP0005075_abnormal_melanosome_morpholog0.72704323
99MP0009765_abnormal_xenobiotic_induced0.72681519
100MP0000604_amyloidosis0.71198659
101MP0000613_abnormal_salivary_gland0.70018677
102MP0002877_abnormal_melanocyte_morpholog0.69800527
103* MP0000653_abnormal_sex_gland0.69653179
104MP0002928_abnormal_bile_duct0.69443751
105MP0005253_abnormal_eye_physiology0.69206887
106MP0005395_other_phenotype0.68685393
107MP0002971_abnormal_brown_adipose0.68094110
108MP0005666_abnormal_adipose_tissue0.65960024
109MP0003718_maternal_effect0.64610510
110* MP0001145_abnormal_male_reproductive0.64262943
111MP0001919_abnormal_reproductive_system0.64052846
112MP0005266_abnormal_metabolism0.63972487
113MP0000627_abnormal_mammary_gland0.62667038
114MP0002396_abnormal_hematopoietic_system0.61707506
115MP0003936_abnormal_reproductive_system0.60802253
116MP0002080_prenatal_lethality0.60417058
117MP0001186_pigmentation_phenotype0.59785433
118MP0010386_abnormal_urinary_bladder0.59462937
119MP0002095_abnormal_skin_pigmentation0.59366813
120MP0000313_abnormal_cell_death0.59025573
121MP0001672_abnormal_embryogenesis/_devel0.58443842
122MP0002168_other_aberrant_phenotype0.56951780
123MP0004130_abnormal_muscle_cell0.56728277
124* MP0005334_abnormal_fat_pad0.55604883
125MP0003724_increased_susceptibility_to0.54865810
126MP0003638_abnormal_response/metabolism_0.54274408
127MP0010368_abnormal_lymphatic_system0.53747888
128MP0000230_abnormal_systemic_arterial0.48086413
129MP0004264_abnormal_extraembryonic_tissu0.47507397
130MP0002135_abnormal_kidney_morphology0.46516457
131MP0009053_abnormal_anal_canal0.44053388
132MP0004782_abnormal_surfactant_physiolog0.43747455
133MP0000538_abnormal_urinary_bladder0.43712879
134MP0003690_abnormal_glial_cell0.43067984
135MP0003953_abnormal_hormone_level0.43025303
136MP0002796_impaired_skin_barrier0.39370344
137MP0009672_abnormal_birth_weight0.39146406
138MP0008873_increased_physiological_sensi0.37311479
139MP0001845_abnormal_inflammatory_respons0.35736086
140MP0005448_abnormal_energy_balance0.35469397
141MP0009115_abnormal_fat_cell0.35011867
142MP0006082_CNS_inflammation0.34773749
143MP0005464_abnormal_platelet_physiology0.34531869
144MP0005166_decreased_susceptibility_to0.32594274
145MP0004147_increased_porphyrin_level0.31017826
146MP0003436_decreased_susceptibility_to0.29521597
147MP0001853_heart_inflammation0.29520456
148MP0000639_abnormal_adrenal_gland0.29013963
149MP0003329_amyloid_beta_deposits0.28893622
150MP0002970_abnormal_white_adipose0.28789290
151MP0003300_gastrointestinal_ulcer0.28622990
152MP0000371_diluted_coat_color0.27716725
153MP0008874_decreased_physiological_sensi0.26775216
154MP0003959_abnormal_lean_body0.25617467
155MP0008872_abnormal_physiological_respon0.25580587
156MP0001881_abnormal_mammary_gland0.24501338
157MP0009384_cardiac_valve_regurgitation0.24109938
158MP0008961_abnormal_basal_metabolism0.23825955
159MP0003075_altered_response_to0.23314372
160MP0004381_abnormal_hair_follicle0.22586277

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.59205108
2Intrahepatic cholestasis (HP:0001406)6.45230300
3Abnormality of monocarboxylic acid metabolism (HP:0010996)5.79585689
4Deep venous thrombosis (HP:0002625)5.61612562
5Acute necrotizing encephalopathy (HP:0006965)5.51929964
6Xanthomatosis (HP:0000991)5.44324404
7Hyperglycinuria (HP:0003108)5.13817706
8Prolonged partial thromboplastin time (HP:0003645)5.09128246
9Abnormal mitochondria in muscle tissue (HP:0008316)5.04295783
10Acute encephalopathy (HP:0006846)5.04187948
11Hypobetalipoproteinemia (HP:0003563)5.00888557
12Abnormality of glutamine family amino acid metabolism (HP:0010902)4.95338033
13Progressive macrocephaly (HP:0004481)4.86306810
14Hyperglycinemia (HP:0002154)4.85762384
15Abnormality of serine family amino acid metabolism (HP:0010894)4.75605503
16Abnormality of glycine metabolism (HP:0010895)4.75605503
17Hyperammonemia (HP:0001987)4.63195866
18Ketosis (HP:0001946)4.53295736
19Mitochondrial inheritance (HP:0001427)4.40939146
20Gout (HP:0001997)4.37780039
21Abnormality of aspartate family amino acid metabolism (HP:0010899)4.35450323
22Complement deficiency (HP:0004431)4.29150573
23Increased hepatocellular lipid droplets (HP:0006565)4.28176323
24Hyperlipoproteinemia (HP:0010980)4.27934510
25Increased CSF lactate (HP:0002490)4.27667914
26Abnormality of sulfur amino acid metabolism (HP:0004339)4.21427527
27Joint hemorrhage (HP:0005261)3.93831909
28Hypoglycemic coma (HP:0001325)3.89749684
29Abnormality of fatty-acid metabolism (HP:0004359)3.85648040
30Lipid accumulation in hepatocytes (HP:0006561)3.85252897
31Hypolipoproteinemia (HP:0010981)3.78077465
32Abnormality of purine metabolism (HP:0004352)3.77843181
33Ketoacidosis (HP:0001993)3.75423725
34Abnormality of nucleobase metabolism (HP:0010932)3.73744444
35Fat malabsorption (HP:0002630)3.72208847
36Epidermoid cyst (HP:0200040)3.70253402
37Abnormality of pyrimidine metabolism (HP:0004353)3.65546970
38Abnormality of methionine metabolism (HP:0010901)3.65348986
39Hepatic necrosis (HP:0002605)3.61816054
40Decreased activity of mitochondrial respiratory chain (HP:0008972)3.54374673
41Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.54374673
42Proximal tubulopathy (HP:0000114)3.52370023
43Reduced antithrombin III activity (HP:0001976)3.50927441
44Delayed CNS myelination (HP:0002188)3.49297664
45Renal Fanconi syndrome (HP:0001994)3.49189350
46Abnormality of the common coagulation pathway (HP:0010990)3.48986401
47Type I transferrin isoform profile (HP:0003642)3.47866161
48Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.44387473
49Hepatocellular necrosis (HP:0001404)3.41222178
50Abnormality of serum amino acid levels (HP:0003112)3.35531357
51Generalized aminoaciduria (HP:0002909)3.33841239
52Hypoalphalipoproteinemia (HP:0003233)3.31810241
53Conjugated hyperbilirubinemia (HP:0002908)3.23252290
54Methylmalonic acidemia (HP:0002912)3.18673693
55Lactic acidosis (HP:0003128)3.18613441
56Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.17443339
57Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.17434907
58Abnormality of alanine metabolism (HP:0010916)3.17434907
59Hyperalaninemia (HP:0003348)3.17434907
60Increased purine levels (HP:0004368)3.16479905
61Hyperuricemia (HP:0002149)3.16479905
623-Methylglutaconic aciduria (HP:0003535)3.14992188
63Dicarboxylic aciduria (HP:0003215)3.13210910
64Abnormality of dicarboxylic acid metabolism (HP:0010995)3.13210910
65Abnormality of the intrinsic pathway (HP:0010989)3.13093136
66Abnormality of complement system (HP:0005339)3.09853993
67Metabolic acidosis (HP:0001942)3.07357139
68Respiratory failure (HP:0002878)3.04273040
69Vascular calcification (HP:0004934)3.00613531
70Alkalosis (HP:0001948)2.97860458
71Increased serum lactate (HP:0002151)2.97308295
72Hyperbilirubinemia (HP:0002904)2.96680445
73Lethargy (HP:0001254)2.95576405
74Exercise intolerance (HP:0003546)2.93686948
75Increased serum pyruvate (HP:0003542)2.86561895
76Hypercholesterolemia (HP:0003124)2.83742660
77Steatorrhea (HP:0002570)2.82696369
78Abnormality of glycolysis (HP:0004366)2.81042005
79Increased intramyocellular lipid droplets (HP:0012240)2.80603234
80Hepatocellular carcinoma (HP:0001402)2.80563778
81Abnormal protein N-linked glycosylation (HP:0012347)2.71948348
82Abnormal protein glycosylation (HP:0012346)2.71948348
83Abnormal glycosylation (HP:0012345)2.71948348
84Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.71948348
85Cardiovascular calcification (HP:0011915)2.66359209
86Glycosuria (HP:0003076)2.65375521
87Abnormality of urine glucose concentration (HP:0011016)2.65375521
88Leukodystrophy (HP:0002415)2.62666757
89Megaloblastic anemia (HP:0001889)2.61826642
90Hydroxyprolinuria (HP:0003080)2.58654392
91Abnormality of proline metabolism (HP:0010907)2.58654392
92Exertional dyspnea (HP:0002875)2.57034784
93Malnutrition (HP:0004395)2.52139426
94Spastic diplegia (HP:0001264)2.50667237
95Irritability (HP:0000737)2.50016244
96Methylmalonic aciduria (HP:0012120)2.48884168
97Vomiting (HP:0002013)2.48283987
98Myocardial infarction (HP:0001658)2.47190543
99Cerebral edema (HP:0002181)2.43488546
100Rickets (HP:0002748)2.42692152
101Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.42347921
102Systemic lupus erythematosus (HP:0002725)2.42192591
103Enlarged kidneys (HP:0000105)2.39998176
104Hypokalemic alkalosis (HP:0001949)2.38981202
105Neonatal onset (HP:0003623)2.34537920
106Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.33901953
107Abnormality of the anterior horn cell (HP:0006802)2.31428536
108Degeneration of anterior horn cells (HP:0002398)2.31428536
109Sensorimotor neuropathy (HP:0007141)2.30540919
110Hypoglycemic seizures (HP:0002173)2.29858331
111Abnormal enzyme/coenzyme activity (HP:0012379)2.28573934
112Macrocytic anemia (HP:0001972)2.27590623
113Hyperactive renin-angiotensin system (HP:0000841)2.26756556
114Skin nodule (HP:0200036)2.26596769
115Abnormality of renal resorption (HP:0011038)2.26299724
116Late onset (HP:0003584)2.25206553
117Pancreatitis (HP:0001733)2.23949550
118CNS demyelination (HP:0007305)2.23384510
119Abnormality of vitamin B metabolism (HP:0004340)2.22216889
120Increased muscle lipid content (HP:0009058)2.22161704
121Increased circulating renin level (HP:0000848)2.20992133
122Hypochromic microcytic anemia (HP:0004840)2.20366375
123Nausea (HP:0002018)2.20103050
124Optic disc pallor (HP:0000543)2.20050994
125Palpitations (HP:0001962)2.17356954
126Abnormality of chromosome stability (HP:0003220)2.15971392
127Hypokinesia (HP:0002375)2.13839597
128Symptomatic seizures (HP:0011145)2.12026916
129Conjunctival hamartoma (HP:0100780)2.10772414
130Spontaneous abortion (HP:0005268)2.09559412
131Patchy hypopigmentation of hair (HP:0011365)2.07754783
132Abnormality of alkaline phosphatase activity (HP:0004379)2.06111096
133Aplasia/Hypoplasia of the sacrum (HP:0008517)2.05633482
134Abnormality of the vitamin B12 metabolism (HP:0004341)2.04076914
135Nephrolithiasis (HP:0000787)2.04059546
136Neoplasm of the adrenal gland (HP:0100631)2.03838428
137Renal cortical cysts (HP:0000803)2.02904489
138Abnormal urine output (HP:0012590)2.02479208
139Birth length less than 3rd percentile (HP:0003561)2.02230325
140Metabolic alkalosis (HP:0200114)2.00962439
141Opisthotonus (HP:0002179)2.00013095
142Abnormality of vitamin metabolism (HP:0100508)1.97892186
143Chromsome breakage (HP:0040012)1.97366947
144Esophageal varix (HP:0002040)1.97306375
145Mitral stenosis (HP:0001718)1.95843823
146Confusion (HP:0001289)1.95537490
147Abnormal cartilage morphology (HP:0002763)1.95505845
148Glomerulonephritis (HP:0000099)1.94279999
149Homocystinuria (HP:0002156)1.93743419
150Abnormality of homocysteine metabolism (HP:0010919)1.93743419
151Hyperphosphaturia (HP:0003109)1.93273879
152Elevated alkaline phosphatase (HP:0003155)1.93070873
153Abnormality of chloride homeostasis (HP:0011422)1.91362885
154Polyuria (HP:0000103)1.90576335
155Hyperinsulinemic hypoglycemia (HP:0000825)1.90071555
156Recurrent gram-negative bacterial infections (HP:0005420)1.89721711
157Brushfield spots (HP:0001088)1.89245821
158Hypomagnesemia (HP:0002917)1.89134395
159Abnormal gallbladder morphology (HP:0012437)1.88577672
160Abnormality of the preputium (HP:0100587)1.86899461
161X-linked dominant inheritance (HP:0001423)1.85615264
162Respiratory difficulties (HP:0002880)1.84292389
163Chromosomal breakage induced by crosslinking agents (HP:0003221)1.83891145
164Neuroendocrine neoplasm (HP:0100634)1.82274105
165Abnormal urine phosphate concentration (HP:0012599)1.79724148
166Microvesicular hepatic steatosis (HP:0001414)1.75140809
167Meckel diverticulum (HP:0002245)1.74512100
168Renal tubular dysfunction (HP:0000124)1.71966391
169Aplasia/Hypoplasia of the uvula (HP:0010293)1.67072418
170Abnormality of the ileum (HP:0001549)1.66310968

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.18390781
2MST44.93160493
3EIF2AK33.81784111
4FGFR43.77351242
5WNK33.73389375
6WNK43.47892565
7SIK13.46097497
8ERN13.29630943
9BUB13.18863793
10OXSR12.78084186
11INSRR2.58562947
12STK38L2.52016178
13VRK22.51467750
14ERBB42.34828153
15CDC72.32955633
16MAP3K122.32827001
17TAOK32.25111029
18BRSK22.12874761
19WEE12.10819713
20MST1R2.02297926
21BMPR1B1.93484468
22PLK31.87815556
23NUAK11.82402695
24SRPK11.81664946
25TRIM281.81456255
26TSSK61.78330252
27MAPK111.74831490
28FLT31.71123238
29PLK41.69263841
30NEK11.64594871
31IRAK31.60826371
32NEK91.57393010
33PINK11.56442614
34NME11.56401151
35LATS11.54698662
36VRK11.51481393
37PIK3CG1.46938773
38PDK31.42515449
39PDK41.42515449
40TYK21.40825384
41ZAK1.36391573
42PLK11.33667341
43ERBB31.31541368
44ABL21.31367587
45FRK1.30256721
46PKN21.28224220
47PRKAA21.24062440
48MAP2K41.24002158
49MAP3K31.21027719
50MAP3K141.20733035
51PAK41.19422229
52MYLK1.19309143
53PDK21.13206359
54TAF11.11231381
55KDR1.10408756
56MAP2K31.05835677
57TNIK1.04828102
58BRSK11.04140458
59AURKB1.03279196
60MKNK21.03246319
61PTK61.02408813
62CCNB10.98864986
63JAK20.93831293
64TRIB30.93388002
65EPHA20.91877108
66LIMK10.91684800
67SGK30.90222139
68SGK4940.89273197
69SGK2230.89273197
70GRK60.87806348
71MAP3K70.86444384
72JAK10.84955372
73PRKAA10.84826994
74GSK3A0.84189042
75TIE10.84026192
76SGK20.83134486
77TGFBR20.82545819
78MKNK10.81748954
79STK390.80799027
80MET0.80013841
81TBK10.79835234
82PLK20.77713331
83PHKG20.77106369
84PHKG10.77106369
85CAMK1D0.77074405
86FER0.74797279
87CDK60.72092332
88PASK0.71441780
89DYRK1B0.71112017
90AKT30.70240103
91ATR0.68410547
92MAP4K20.67654545
93PRKCI0.65866226
94RPS6KB20.65152209
95EPHB10.63912939
96STK40.63032595
97PRKACG0.62208149
98PRKCZ0.61045992
99CSNK2A20.60098284
100MAPK40.58771986
101CDK70.58396133
102CSNK2A10.58337770
103ERBB20.56236619
104AURKA0.54981245
105IRAK10.53887050
106CSK0.53731177
107CHEK20.53230782
108MAP3K110.52841663
109MAPK150.52533068
110CHEK10.51776609
111ATM0.51677077
112BMPR20.51463533
113EIF2AK10.50930856
114MAP2K60.50330057
115STK380.49371638
116ARAF0.49281141
117FGFR20.48974594
118PDPK10.48974247
119CDK40.48887299
120PTK20.47316423
121GRK10.46920234
122STK160.46567902
123DAPK20.46121269
124BCR0.45827357
125CSNK1G30.45731946
126TAOK20.45376395
127PBK0.44548774
128NME20.44386468
129STK100.44304109
130OBSCN0.44165583
131PNCK0.42718754
132MAP3K50.42533723
133DAPK10.41414392
134MAPK120.41351584
135SCYL20.41304652
136ILK0.40877242
137IRAK20.39983957
138IKBKE0.39926028
139CDK90.38880665
140CSNK1G20.38444261
141ACVR1B0.38262265
142MTOR0.37793741
143PIM10.37780594
144PRKCE0.37192291
145STK30.35863465
146FGFR30.35690321
147CDK80.35665233
148TLK10.34948067
149MUSK0.34782410
150TESK10.34266495
151FGFR10.34008036
152IGF1R0.33850933
153PIM20.33308387
154CAMK2G0.32527047
155YES10.32082365
156CSF1R0.32026084
157AKT20.31326818
158STK240.31320330
159CSNK1E0.30156931
160NEK20.30152681
161MAPK70.29723152
162PDK10.28748747
163CHUK0.24426215
164EPHA30.24379561
165LRRK20.23477525
166CSNK1G10.22253590
167TTK0.21146316
168IKBKB0.20652117
169PRKCA0.19961604
170EIF2AK20.19711110
171PRKCD0.19611045

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.97989399
2Proteasome_Homo sapiens_hsa030503.69821698
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.44164639
4Protein export_Homo sapiens_hsa030603.30965305
5Oxidative phosphorylation_Homo sapiens_hsa001903.15307578
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.09041474
7Nitrogen metabolism_Homo sapiens_hsa009103.03268892
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.91291924
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.74985327
10Tryptophan metabolism_Homo sapiens_hsa003802.73675028
11Arginine biosynthesis_Homo sapiens_hsa002202.68994959
12Fatty acid degradation_Homo sapiens_hsa000712.60064188
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.59188303
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.53137245
15Butanoate metabolism_Homo sapiens_hsa006502.51561977
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.44783979
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.42991448
18Parkinsons disease_Homo sapiens_hsa050122.41572349
19Mismatch repair_Homo sapiens_hsa034302.40308955
20Ribosome_Homo sapiens_hsa030102.39329216
21Propanoate metabolism_Homo sapiens_hsa006402.37296246
22Peroxisome_Homo sapiens_hsa041462.31653325
23Complement and coagulation cascades_Homo sapiens_hsa046102.18155444
24DNA replication_Homo sapiens_hsa030302.12591497
25Homologous recombination_Homo sapiens_hsa034402.08989055
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.95175332
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.90383332
28Fatty acid metabolism_Homo sapiens_hsa012121.89974085
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.89768157
30beta-Alanine metabolism_Homo sapiens_hsa004101.87307484
31PPAR signaling pathway_Homo sapiens_hsa033201.81316648
32Nucleotide excision repair_Homo sapiens_hsa034201.80168982
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.79958399
34Histidine metabolism_Homo sapiens_hsa003401.77698033
35RNA polymerase_Homo sapiens_hsa030201.75639858
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.73373282
37Chemical carcinogenesis_Homo sapiens_hsa052041.73208024
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.72526259
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.70397100
40Huntingtons disease_Homo sapiens_hsa050161.68907355
41Pyruvate metabolism_Homo sapiens_hsa006201.67107681
42Selenocompound metabolism_Homo sapiens_hsa004501.65589697
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.63940226
44Cyanoamino acid metabolism_Homo sapiens_hsa004601.62479745
45Alzheimers disease_Homo sapiens_hsa050101.61858042
46Retinol metabolism_Homo sapiens_hsa008301.53557628
47Bile secretion_Homo sapiens_hsa049761.47461792
48Non-homologous end-joining_Homo sapiens_hsa034501.47316258
49Phenylalanine metabolism_Homo sapiens_hsa003601.47284329
50Caffeine metabolism_Homo sapiens_hsa002321.41938336
51Folate biosynthesis_Homo sapiens_hsa007901.41479240
52Sulfur metabolism_Homo sapiens_hsa009201.40788929
53Basal transcription factors_Homo sapiens_hsa030221.37905686
54Carbon metabolism_Homo sapiens_hsa012001.35418948
55Staphylococcus aureus infection_Homo sapiens_hsa051501.35077165
56Starch and sucrose metabolism_Homo sapiens_hsa005001.33763573
57RNA transport_Homo sapiens_hsa030131.33525633
58Fanconi anemia pathway_Homo sapiens_hsa034601.30415822
59Cysteine and methionine metabolism_Homo sapiens_hsa002701.29347546
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26508071
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.25456675
62Biosynthesis of amino acids_Homo sapiens_hsa012301.25123243
63Tyrosine metabolism_Homo sapiens_hsa003501.24990665
64Vitamin digestion and absorption_Homo sapiens_hsa049771.22798789
65Spliceosome_Homo sapiens_hsa030401.22118521
66Fatty acid elongation_Homo sapiens_hsa000621.18681021
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.18268223
68Base excision repair_Homo sapiens_hsa034101.13000638
69RNA degradation_Homo sapiens_hsa030181.12061703
70Arginine and proline metabolism_Homo sapiens_hsa003301.11435483
71Steroid biosynthesis_Homo sapiens_hsa001001.05047466
72Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.03849626
73ABC transporters_Homo sapiens_hsa020101.03546176
74Maturity onset diabetes of the young_Homo sapiens_hsa049501.03219690
75Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.00688141
76Lysine degradation_Homo sapiens_hsa003100.97102106
77Glutathione metabolism_Homo sapiens_hsa004800.94740483
78Fat digestion and absorption_Homo sapiens_hsa049750.92059352
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91869169
80Vitamin B6 metabolism_Homo sapiens_hsa007500.91645232
81One carbon pool by folate_Homo sapiens_hsa006700.90270438
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89361156
83Sulfur relay system_Homo sapiens_hsa041220.84730114
84Purine metabolism_Homo sapiens_hsa002300.84024706
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82708418
86N-Glycan biosynthesis_Homo sapiens_hsa005100.80869408
87Cell cycle_Homo sapiens_hsa041100.78065073
88Glycerolipid metabolism_Homo sapiens_hsa005610.76865693
89Pentose phosphate pathway_Homo sapiens_hsa000300.69596519
90Cardiac muscle contraction_Homo sapiens_hsa042600.55797942
91Metabolic pathways_Homo sapiens_hsa011000.54658301
92Fructose and mannose metabolism_Homo sapiens_hsa000510.49324738
93Fatty acid biosynthesis_Homo sapiens_hsa000610.40699495
94Vibrio cholerae infection_Homo sapiens_hsa051100.40680254
95p53 signaling pathway_Homo sapiens_hsa041150.36984639
96Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.36601782
97Oocyte meiosis_Homo sapiens_hsa041140.34517482
98Galactose metabolism_Homo sapiens_hsa000520.31426185
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31284269
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26955336
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24712387
102mRNA surveillance pathway_Homo sapiens_hsa030150.22972972
103Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19414954
104Insulin resistance_Homo sapiens_hsa049310.18724285
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.18112014
106Prion diseases_Homo sapiens_hsa050200.15814978
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.11280266
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.10631883
109Linoleic acid metabolism_Homo sapiens_hsa005910.09847840
110Other glycan degradation_Homo sapiens_hsa005110.08630847
111Renin-angiotensin system_Homo sapiens_hsa046140.05910158
112Glycosaminoglycan degradation_Homo sapiens_hsa005310.02752630
113Glucagon signaling pathway_Homo sapiens_hsa049220.01930919
114Protein digestion and absorption_Homo sapiens_hsa049740.01464094
115Arachidonic acid metabolism_Homo sapiens_hsa005900.01402025
116AMPK signaling pathway_Homo sapiens_hsa041520.01123017
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2172919
118Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.2035324
119Collecting duct acid secretion_Homo sapiens_hsa04966-0.1969329
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1905642
121Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1837830
122Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1775011
123Insulin signaling pathway_Homo sapiens_hsa04910-0.1680837
124Pyrimidine metabolism_Homo sapiens_hsa00240-0.1530161
125Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1516792
126Hepatitis C_Homo sapiens_hsa05160-0.1495928
127Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1337679
128Lysosome_Homo sapiens_hsa04142-0.0603056
129Mineral absorption_Homo sapiens_hsa04978-0.0254648
130Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0105878
131Regulation of autophagy_Homo sapiens_hsa04140-0.0076478

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