L3MBTL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of inclusion body assembly (GO:0090084)6.35767582
2negative regulation of mesenchymal cell apoptotic process (GO:2001054)5.94318020
3negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)5.82384465
4protein refolding (GO:0042026)5.81420622
5neuron fate determination (GO:0048664)5.80716059
6neuronal stem cell maintenance (GO:0097150)5.60953998
7nephron epithelium morphogenesis (GO:0072088)5.25225283
8nephron tubule morphogenesis (GO:0072078)5.25225283
9radial glial cell differentiation (GO:0060019)5.25214025
10DNA replication initiation (GO:0006270)4.98263374
11rRNA catabolic process (GO:0016075)4.87782127
12DNA unwinding involved in DNA replication (GO:0006268)4.74178028
13astrocyte differentiation (GO:0048708)4.62887880
14DNA replication-dependent nucleosome organization (GO:0034723)4.60848092
15DNA replication-dependent nucleosome assembly (GO:0006335)4.60848092
16regulation of mesenchymal cell apoptotic process (GO:2001053)4.55400774
17central nervous system myelination (GO:0022010)4.55179752
18axon ensheathment in central nervous system (GO:0032291)4.55179752
19pattern specification involved in kidney development (GO:0061004)4.55037704
20regulation of gene silencing by RNA (GO:0060966)4.53780966
21regulation of posttranscriptional gene silencing (GO:0060147)4.53780966
22regulation of gene silencing by miRNA (GO:0060964)4.53780966
23protein localization to kinetochore (GO:0034501)4.50137007
24DNA replication checkpoint (GO:0000076)4.49516757
25axonemal dynein complex assembly (GO:0070286)4.42966924
26DNA strand elongation involved in DNA replication (GO:0006271)4.40483786
27nucleobase biosynthetic process (GO:0046112)4.39787963
28auditory receptor cell differentiation (GO:0042491)4.37597121
29peptidyl-histidine modification (GO:0018202)4.29568210
30motile cilium assembly (GO:0044458)4.29077552
31regulation of microtubule-based movement (GO:0060632)4.24905617
32negative regulation of oligodendrocyte differentiation (GO:0048715)4.22800939
33mitotic metaphase plate congression (GO:0007080)4.18403068
34maturation of SSU-rRNA (GO:0030490)4.18168128
35cilium or flagellum-dependent cell motility (GO:0001539)4.15182006
36DNA strand elongation (GO:0022616)4.13821999
37formation of translation preinitiation complex (GO:0001731)4.11965927
38mitotic sister chromatid segregation (GO:0000070)4.09647198
39IMP biosynthetic process (GO:0006188)4.04097069
40nuclear pore organization (GO:0006999)4.03722347
41somatic hypermutation of immunoglobulin genes (GO:0016446)3.92866663
42somatic diversification of immune receptors via somatic mutation (GO:0002566)3.92866663
43establishment of protein localization to mitochondrial membrane (GO:0090151)3.92827761
44regulation of inclusion body assembly (GO:0090083)3.91934598
45purine nucleobase biosynthetic process (GO:0009113)3.90119466
46establishment of integrated proviral latency (GO:0075713)3.90082943
47ribosome assembly (GO:0042255)3.88411197
48regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.86711782
49folic acid-containing compound biosynthetic process (GO:0009396)3.85193331
50mitotic nuclear envelope disassembly (GO:0007077)3.81023767
51chaperone mediated protein folding requiring cofactor (GO:0051085)3.76381061
52ribosome biogenesis (GO:0042254)3.75986111
53positive regulation of chromosome segregation (GO:0051984)3.74566695
54nuclear pore complex assembly (GO:0051292)3.72436978
55DNA ligation (GO:0006266)3.68822128
56protein localization to chromosome, centromeric region (GO:0071459)3.68404803
57telomere maintenance via semi-conservative replication (GO:0032201)3.64194790
58epithelial cilium movement (GO:0003351)3.63382824
59response to misfolded protein (GO:0051788)3.62937837
60centriole replication (GO:0007099)3.62353019
61metaphase plate congression (GO:0051310)3.60327432
62cilium movement (GO:0003341)3.55518721
63nuclear envelope disassembly (GO:0051081)3.51869751
64membrane disassembly (GO:0030397)3.51869751
65renal tubule morphogenesis (GO:0061333)3.50134606
66mitochondrion morphogenesis (GO:0070584)3.50026307
67sister chromatid segregation (GO:0000819)3.49980794
68ribonucleoprotein complex biogenesis (GO:0022613)3.49897623
69rRNA processing (GO:0006364)3.46808685
70IMP metabolic process (GO:0046040)3.44451649
71spliceosomal snRNP assembly (GO:0000387)3.44190857
72otic vesicle formation (GO:0030916)3.43690163
73meiosis I (GO:0007127)3.40026049
74centriole assembly (GO:0098534)3.39806833
75forebrain neuron differentiation (GO:0021879)3.36784155
76spliceosomal tri-snRNP complex assembly (GO:0000244)3.36705934
77negative regulation of astrocyte differentiation (GO:0048712)3.36139519
78regulation of helicase activity (GO:0051095)3.35828191
79DNA topological change (GO:0006265)3.35774517
80regulation of histone H3-K9 methylation (GO:0051570)3.35405180
81rRNA metabolic process (GO:0016072)3.35384855
82regulation of translational fidelity (GO:0006450)3.35133939
83ribosomal small subunit biogenesis (GO:0042274)3.31982921
84male meiosis I (GO:0007141)3.31341905
85regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.29855738
86epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.28507440
87misfolded or incompletely synthesized protein catabolic process (GO:0006515)3.28428010
88protein K6-linked ubiquitination (GO:0085020)3.27870392
89DNA duplex unwinding (GO:0032508)3.27835639
90DNA geometric change (GO:0032392)3.26998936
91RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.25572097
92tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.25572097
93regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.24707819
94nephron tubule formation (GO:0072079)3.24092184
95chromatin remodeling at centromere (GO:0031055)3.23774447
96histone arginine methylation (GO:0034969)3.21928336
97ribosomal large subunit biogenesis (GO:0042273)3.21548686
98mitotic chromosome condensation (GO:0007076)3.18801146
99nucleotide-excision repair, DNA gap filling (GO:0006297)3.18731352
100limb bud formation (GO:0060174)3.17877323
101regulation of centrosome cycle (GO:0046605)3.17291973
102positive regulation of response to oxidative stress (GO:1902884)3.15889809
103positive regulation of cellular response to oxidative stress (GO:1900409)3.15889809
104CENP-A containing nucleosome assembly (GO:0034080)3.15097015
105pre-miRNA processing (GO:0031054)3.13461945
106transcription elongation from RNA polymerase I promoter (GO:0006362)3.13323852
107establishment of chromosome localization (GO:0051303)3.13000312
108chaperone-mediated protein complex assembly (GO:0051131)3.10605795
109negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.10580412
110negative regulation of translation, ncRNA-mediated (GO:0040033)3.10580412
111regulation of translation, ncRNA-mediated (GO:0045974)3.10580412
112telomere maintenance via recombination (GO:0000722)3.08889153
113male meiosis (GO:0007140)3.06855412
114negative regulation of histone methylation (GO:0031061)3.04777643
115DNA replication-independent nucleosome assembly (GO:0006336)3.04145315
116DNA replication-independent nucleosome organization (GO:0034724)3.04145315
117rRNA modification (GO:0000154)3.04131903
118mitochondrial RNA metabolic process (GO:0000959)3.03242907
119telomere maintenance via telomere lengthening (GO:0010833)3.02749096
120regulation of spindle organization (GO:0090224)3.02368151
121transcription-coupled nucleotide-excision repair (GO:0006283)3.01988216
122mitotic recombination (GO:0006312)2.99147549
123heart valve formation (GO:0003188)2.99138840
124spliceosomal complex assembly (GO:0000245)2.98471968
125transcription from RNA polymerase I promoter (GO:0006360)2.98013163
126neuroblast proliferation (GO:0007405)2.97713251
127pseudouridine synthesis (GO:0001522)2.97161480
128maturation of 5.8S rRNA (GO:0000460)2.96335891
129termination of RNA polymerase I transcription (GO:0006363)2.96016306
130kinetochore organization (GO:0051383)2.95433283
131pore complex assembly (GO:0046931)2.94298673
132regulation of centriole replication (GO:0046599)2.94273854
133regulation of chromosome segregation (GO:0051983)2.93162290
134histone exchange (GO:0043486)2.93025442
135histone H4-K12 acetylation (GO:0043983)2.92912493
136piRNA metabolic process (GO:0034587)2.92622219
137determination of adult lifespan (GO:0008340)2.92490429
138attachment of spindle microtubules to kinetochore (GO:0008608)2.91697276
139nonmotile primary cilium assembly (GO:0035058)2.90974401
140peptidyl-arginine omega-N-methylation (GO:0035247)2.90927752
141establishment of viral latency (GO:0019043)2.90602773
142multicellular organism reproduction (GO:0032504)2.90485571
143translational initiation (GO:0006413)2.89901228
144histone H2A acetylation (GO:0043968)2.89626762
145mismatch repair (GO:0006298)2.87899337
146positive regulation of Notch signaling pathway (GO:0045747)2.87493573
147UTP biosynthetic process (GO:0006228)2.86137125
148regulation of nuclear cell cycle DNA replication (GO:0033262)2.84034104
149termination of RNA polymerase III transcription (GO:0006386)2.84002454
150transcription elongation from RNA polymerase III promoter (GO:0006385)2.84002454
151protein complex localization (GO:0031503)2.83852383
152folic acid metabolic process (GO:0046655)2.82761786
153positive regulation of male gonad development (GO:2000020)2.82698805
154transcription initiation from RNA polymerase I promoter (GO:0006361)2.82451319
155kinetochore assembly (GO:0051382)2.82134236
156regulation of hematopoietic progenitor cell differentiation (GO:1901532)2.78633874
157sperm motility (GO:0030317)2.78557542
158mitotic cell cycle arrest (GO:0071850)2.78356798
159cullin deneddylation (GO:0010388)2.78292573
160apoptotic DNA fragmentation (GO:0006309)2.77653571
161anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.77549085
162chromosome condensation (GO:0030261)2.76846990
163male sex determination (GO:0030238)2.76712338
164microtubule depolymerization (GO:0007019)2.76512377
165segment specification (GO:0007379)2.75742163
166negative regulation of chromosome segregation (GO:0051985)2.75705433
167nuclear envelope organization (GO:0006998)2.75606732
168chromatin assembly (GO:0031497)2.75532598
169single strand break repair (GO:0000012)2.74838545
170ncRNA catabolic process (GO:0034661)2.74344049
171DNA methylation involved in gamete generation (GO:0043046)2.72218154
172cornea development in camera-type eye (GO:0061303)2.68673072
173regulation of cilium movement (GO:0003352)2.67162497
174telencephalon development (GO:0021537)2.64370133
175negative regulation of telomere maintenance (GO:0032205)2.62321384
176response to methylmercury (GO:0051597)2.61110083
177regulation of mitotic spindle organization (GO:0060236)2.58965038
178GTP biosynthetic process (GO:0006183)2.57305426
179cilium organization (GO:0044782)2.55404834
180negative regulation of glial cell differentiation (GO:0045686)2.54481411
181sperm capacitation (GO:0048240)2.53736880

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.17647823
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.21761091
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.84200271
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.56936513
5* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.42174447
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.36562424
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.03062991
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.96596967
9* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.93850473
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.87984147
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.82228640
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.80810130
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.80311605
14* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.72909080
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.65409425
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.63810676
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.52129550
18SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.51579198
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.49179887
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.40533896
21ZNF274_21170338_ChIP-Seq_K562_Hela2.36920511
22* NANOG_18555785_ChIP-Seq_MESCs_Mouse2.32465318
23* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.31793030
24KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.30754932
25KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.30754932
26KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.30754932
27POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.26388892
28XRN2_22483619_ChIP-Seq_HELA_Human2.22632308
29NOTCH1_21737748_ChIP-Seq_TLL_Human2.21796145
30NELFA_20434984_ChIP-Seq_ESCs_Mouse2.19998577
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.19538452
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.18266178
33* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.05118208
34MYCN_18555785_ChIP-Seq_MESCs_Mouse2.00178427
35* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.99359596
36NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.96940888
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.94722338
38* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.92470627
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.91606524
40VDR_23849224_ChIP-Seq_CD4+_Human1.91021748
41AR_21909140_ChIP-Seq_LNCAP_Human1.88429719
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.86080994
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85331853
44* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.79963547
45EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.77839090
46POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.76925611
47FOXP3_21729870_ChIP-Seq_TREG_Human1.74606627
48NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.71578791
49* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.71404869
50TTF2_22483619_ChIP-Seq_HELA_Human1.68447014
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.66173829
52SOX2_18555785_ChIP-Seq_MESCs_Mouse1.66004554
53* DCP1A_22483619_ChIP-Seq_HELA_Human1.63690472
54AR_21572438_ChIP-Seq_LNCaP_Human1.63159522
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61938374
56* E2F1_21310950_ChIP-Seq_MCF-7_Human1.59729821
57GABP_19822575_ChIP-Seq_HepG2_Human1.59294564
58NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.59106738
59STAT3_1855785_ChIP-Seq_MESCs_Mouse1.57362270
60TCF3_18692474_ChIP-Seq_MEFs_Mouse1.55195410
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.54805911
62TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53488538
63RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.52810463
64P68_20966046_ChIP-Seq_HELA_Human1.52468902
65PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.48156416
66CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.46070318
67TCF3_18692474_ChIP-Seq_MESCs_Mouse1.45647383
68ELF1_20517297_ChIP-Seq_JURKAT_Human1.43006299
69TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.42953673
70KDM5A_27292631_Chip-Seq_BREAST_Human1.41991090
71E2F1_20622854_ChIP-Seq_HELA_Human1.41104172
72CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.40886081
73CIITA_25753668_ChIP-Seq_RAJI_Human1.40463254
74PHF8_20622854_ChIP-Seq_HELA_Human1.36936374
75* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.36669288
76SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.35278809
77KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.32584044
78KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.31420195
79CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28133891
80SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.25058370
81PKCTHETA_26484144_Chip-Seq_BREAST_Human1.24599367
82BCL6_27268052_Chip-Seq_Bcells_Human1.24358861
83BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.23368961
84SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.23336251
85EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22678696
86ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.22657889
87KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22633755
88GATA1_22025678_ChIP-Seq_K562_Human1.22440476
89CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21962947
90ELK1_19687146_ChIP-ChIP_HELA_Human1.21612468
91ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21282731
92PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19023102
93SOX2_18692474_ChIP-Seq_MEFs_Mouse1.18652985
94* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.17450125
95VDR_21846776_ChIP-Seq_THP-1_Human1.17166837
96* NANOG_21062744_ChIP-ChIP_HESCs_Human1.17116257
97ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.15256251
98SOX2_18692474_ChIP-Seq_MESCs_Mouse1.13672451
99POU5F1_16518401_ChIP-PET_MESCs_Mouse1.13135895
100FOXP1_21924763_ChIP-Seq_HESCs_Human1.12803703
101ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12190895
102TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12101676
103* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.10969228
104SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.10539205
105TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10514609
106CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.10325839
107IRF1_19129219_ChIP-ChIP_H3396_Human1.10237683
108PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09511679
109OCT4_18692474_ChIP-Seq_MEFs_Mouse1.08473036
110BCOR_27268052_Chip-Seq_Bcells_Human1.08409366
111* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08217364
112SMC4_20622854_ChIP-Seq_HELA_Human1.06666577
113ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06430877
114NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05351686
115DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05192187
116POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.04992880
117WDR5_24793694_ChIP-Seq_LNCAP_Human1.04694722
118FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04689903
119PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04077648
120NANOG_18692474_ChIP-Seq_MEFs_Mouse1.04027672
121SA1_27219007_Chip-Seq_ERYTHROID_Human1.02693425
122* SRF_21415370_ChIP-Seq_HL-1_Mouse1.02417162
123E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01828109
124E2F1_17053090_ChIP-ChIP_MCF-7_Human1.01126735
125ERA_21632823_ChIP-Seq_H3396_Human1.00592862
126TFEB_21752829_ChIP-Seq_HELA_Human0.99718394
127SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.99409127
128E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98831481
129NANOG_18692474_ChIP-Seq_MESCs_Mouse0.98050789
130FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.97660608
131CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97253164
132LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96253242
133MYC_22102868_ChIP-Seq_BL_Human0.95618042
134RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95124110
135ELF1_17652178_ChIP-ChIP_JURKAT_Human0.95105030
136CTCF_20526341_ChIP-Seq_ESCs_Human0.94704809
137MAF_26560356_Chip-Seq_TH2_Human0.93401274
138HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93053174
139HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92874013
140GATA3_21878914_ChIP-Seq_MCF-7_Human0.92505505
141TAF2_19829295_ChIP-Seq_ESCs_Human0.92301376
142* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.91210851
143MYC_18940864_ChIP-ChIP_HL60_Human0.90005320
144RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.89719492
145KAP1_27257070_Chip-Seq_ESCs_Mouse0.88619831
146SOX2_16153702_ChIP-ChIP_HESCs_Human0.87358297
147CTBP1_25329375_ChIP-Seq_LNCAP_Human0.87279599
148YY1_22570637_ChIP-Seq_MALME-3M_Human0.85936564
149IKZF1_21737484_ChIP-ChIP_HCT116_Human0.85567896
150ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83948450

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.48161810
2MP0010094_abnormal_chromosome_stability4.55743701
3MP0003693_abnormal_embryo_hatching4.49892013
4MP0003111_abnormal_nucleus_morphology4.44990233
5MP0004957_abnormal_blastocyst_morpholog4.39704999
6MP0003077_abnormal_cell_cycle3.85259763
7MP0008058_abnormal_DNA_repair3.34890238
8MP0003806_abnormal_nucleotide_metabolis3.27553459
9MP0003136_yellow_coat_color3.26078805
10MP0008877_abnormal_DNA_methylation3.01497895
11MP0008932_abnormal_embryonic_tissue2.76156094
12MP0001730_embryonic_growth_arrest2.73951609
13MP0002638_abnormal_pupillary_reflex2.73783613
14MP0002736_abnormal_nociception_after2.52258395
15MP0004742_abnormal_vestibular_system2.46384438
16MP0001968_abnormal_touch/_nociception2.31485780
17MP0003718_maternal_effect2.28033839
18MP0000350_abnormal_cell_proliferation2.24874079
19MP0009384_cardiac_valve_regurgitation2.18805784
20MP0002653_abnormal_ependyma_morphology2.17020034
21MP0004133_heterotaxia2.15758495
22MP0002282_abnormal_trachea_morphology2.07944089
23MP0001984_abnormal_olfaction2.04863696
24MP0003786_premature_aging2.00443008
25MP0005253_abnormal_eye_physiology1.89224867
26MP0000749_muscle_degeneration1.84787964
27MP0008007_abnormal_cellular_replicative1.84091173
28MP0003123_paternal_imprinting1.84054760
29MP0003890_abnormal_embryonic-extraembry1.80890817
30MP0001697_abnormal_embryo_size1.80431646
31MP0005380_embryogenesis_phenotype1.80338600
32MP0001672_abnormal_embryogenesis/_devel1.80338600
33MP0002085_abnormal_embryonic_tissue1.79444386
34MP0002084_abnormal_developmental_patter1.77342738
35MP0001529_abnormal_vocalization1.73404611
36MP0003787_abnormal_imprinting1.66570326
37MP0005171_absent_coat_pigmentation1.63650748
38MP0002080_prenatal_lethality1.62286359
39MP0010307_abnormal_tumor_latency1.57369556
40MP0003172_abnormal_lysosome_physiology1.51956221
41MP0002102_abnormal_ear_morphology1.47768750
42MP0002210_abnormal_sex_determination1.45565174
43MP0009745_abnormal_behavioral_response1.45062968
44MP0003984_embryonic_growth_retardation1.44815362
45MP0001929_abnormal_gametogenesis1.43916419
46MP0002735_abnormal_chemical_nociception1.42921582
47MP0005377_hearing/vestibular/ear_phenot1.41006806
48MP0003878_abnormal_ear_physiology1.41006806
49MP0002088_abnormal_embryonic_growth/wei1.39607129
50MP0001145_abnormal_male_reproductive1.37844853
51MP0002086_abnormal_extraembryonic_tissu1.36123418
52MP0002064_seizures1.35615780
53MP0004197_abnormal_fetal_growth/weight/1.34607577
54MP0000049_abnormal_middle_ear1.31147094
55MP0003119_abnormal_digestive_system1.30078770
56MP0001764_abnormal_homeostasis1.30044232
57MP0002277_abnormal_respiratory_mucosa1.29644296
58MP0010352_gastrointestinal_tract_polyps1.26010620
59MP0002938_white_spotting1.25692643
60MP0005551_abnormal_eye_electrophysiolog1.23984576
61MP0001986_abnormal_taste_sensitivity1.23708685
62MP0000313_abnormal_cell_death1.19576694
63MP0002067_abnormal_sensory_capabilities1.19344745
64MP0000026_abnormal_inner_ear1.18126782
65MP0003121_genomic_imprinting1.17611743
66MP0005499_abnormal_olfactory_system1.16397075
67MP0005394_taste/olfaction_phenotype1.16397075
68MP0001293_anophthalmia1.15935828
69MP0003698_abnormal_male_reproductive1.15883251
70MP0003763_abnormal_thymus_physiology1.15304679
71MP0008789_abnormal_olfactory_epithelium1.13656722
72MP0006292_abnormal_olfactory_placode1.12161814
73MP0000653_abnormal_sex_gland1.12066084
74MP0002928_abnormal_bile_duct1.10859648
75MP0005410_abnormal_fertilization1.10776466
76MP0003861_abnormal_nervous_system1.10132181
77MP0003632_abnormal_nervous_system1.09625718
78MP0004233_abnormal_muscle_weight1.09420036
79MP0001963_abnormal_hearing_physiology1.07681277
80MP0005174_abnormal_tail_pigmentation1.07144392
81MP0001188_hyperpigmentation1.03645543
82MP0001485_abnormal_pinna_reflex1.02662014
83MP0002063_abnormal_learning/memory/cond1.01866654
84MP0002249_abnormal_larynx_morphology1.01395220
85MP0005075_abnormal_melanosome_morpholog1.00610076
86MP0005195_abnormal_posterior_eye1.00269117
87MP0002272_abnormal_nervous_system0.99809651
88MP0005266_abnormal_metabolism0.98778344
89MP0001270_distended_abdomen0.95969951
90MP0001727_abnormal_embryo_implantation0.95159525
91MP0002019_abnormal_tumor_incidence0.94516967
92MP0002161_abnormal_fertility/fecundity0.92228352
93MP0003950_abnormal_plasma_membrane0.89275287
94MP0003937_abnormal_limbs/digits/tail_de0.88158592
95MP0002572_abnormal_emotion/affect_behav0.87222428
96MP0000358_abnormal_cell_content/0.84564428
97MP0003938_abnormal_ear_development0.84013517
98MP0002733_abnormal_thermal_nociception0.83460562
99MP0003635_abnormal_synaptic_transmissio0.82516541
100MP0002160_abnormal_reproductive_system0.82431651
101MP0004142_abnormal_muscle_tone0.81567322
102MP0001502_abnormal_circadian_rhythm0.81274648
103MP0000537_abnormal_urethra_morphology0.77625690
104MP0001919_abnormal_reproductive_system0.77449474
105MP0005310_abnormal_salivary_gland0.77398813
106MP0008872_abnormal_physiological_respon0.77066192
107MP0005384_cellular_phenotype0.76638399
108MP0002557_abnormal_social/conspecific_i0.76630703
109MP0006072_abnormal_retinal_apoptosis0.76043014
110MP0006035_abnormal_mitochondrial_morpho0.75218064
111MP0003567_abnormal_fetal_cardiomyocyte0.74957245
112MP0005083_abnormal_biliary_tract0.74243026
113MP0001905_abnormal_dopamine_level0.73955996
114MP0003959_abnormal_lean_body0.73562443
115MP0000490_abnormal_crypts_of0.73193679
116MP0001324_abnormal_eye_pigmentation0.71376926
117MP0001661_extended_life_span0.70702646
118MP0008770_decreased_survivor_rate0.70549939
119MP0002152_abnormal_brain_morphology0.70387196
120MP0002111_abnormal_tail_morphology0.70365395
121MP0001970_abnormal_pain_threshold0.70139093
122MP0005621_abnormal_cell_physiology0.69875452
123MP0005084_abnormal_gallbladder_morpholo0.69645498
124MP0005423_abnormal_somatic_nervous0.69464985
125MP0000631_abnormal_neuroendocrine_gland0.69414310
126MP0001486_abnormal_startle_reflex0.68811172
127MP0004808_abnormal_hematopoietic_stem0.67389513
128MP0004147_increased_porphyrin_level0.67256707
129MP0009703_decreased_birth_body0.67255942
130MP0006036_abnormal_mitochondrial_physio0.66864783
131MP0000343_altered_response_to0.66702160
132MP0003011_delayed_dark_adaptation0.65797489
133MP0009672_abnormal_birth_weight0.64160670
134MP0003315_abnormal_perineum_morphology0.63818857
135MP0002075_abnormal_coat/hair_pigmentati0.63227329
136MP0004885_abnormal_endolymph0.60865982
137MP0005389_reproductive_system_phenotype0.59179670
138MP0005395_other_phenotype0.58688617
139MP0003880_abnormal_central_pattern0.56813379
140MP0003283_abnormal_digestive_organ0.56680509
141MP0002269_muscular_atrophy0.55831692
142MP0000955_abnormal_spinal_cord0.55711146
143MP0010030_abnormal_orbit_morphology0.55709310
144MP0003699_abnormal_female_reproductive0.55168325
145MP0000703_abnormal_thymus_morphology0.55124288
146MP0004270_analgesia0.55102042
147MP0005391_vision/eye_phenotype0.54900576
148MP0001849_ear_inflammation0.54338479
149MP0002396_abnormal_hematopoietic_system0.53712136
150MP0003936_abnormal_reproductive_system0.52292453
151MP0009046_muscle_twitch0.52020051
152MP0001286_abnormal_eye_development0.51651155
153MP0000778_abnormal_nervous_system0.50782351
154MP0002092_abnormal_eye_morphology0.50181105
155MP0002229_neurodegeneration0.49674929
156MP0003329_amyloid_beta_deposits0.49526850
157MP0000015_abnormal_ear_pigmentation0.49491047
158MP0005501_abnormal_skin_physiology0.49452935

Predicted human phenotypes

RankGene SetZ-score
111 pairs of ribs (HP:0000878)6.10601692
2Birth length less than 3rd percentile (HP:0003561)5.18595595
3Abnormality of the labia minora (HP:0012880)4.89977183
4Hypoplastic iliac wings (HP:0002866)4.89177118
5Type II lissencephaly (HP:0007260)4.68951468
6Abnormal respiratory epithelium morphology (HP:0012253)4.68224509
7Abnormal respiratory motile cilium morphology (HP:0005938)4.68224509
8Cerebral hypomyelination (HP:0006808)4.67714638
9Abnormal ciliary motility (HP:0012262)4.49593652
10Ependymoma (HP:0002888)4.48902607
11Breast hypoplasia (HP:0003187)4.47248038
12True hermaphroditism (HP:0010459)4.38734737
13Dynein arm defect of respiratory motile cilia (HP:0012255)4.09936747
14Absent/shortened dynein arms (HP:0200106)4.09936747
15Abnormal respiratory motile cilium physiology (HP:0012261)4.06641177
16Rhinitis (HP:0012384)3.86850152
17Cerebellar dysplasia (HP:0007033)3.81242971
18Molar tooth sign on MRI (HP:0002419)3.75060020
19Abnormality of midbrain morphology (HP:0002418)3.75060020
20Hypoplasia of the pons (HP:0012110)3.67050623
21Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.49892313
22Absent radius (HP:0003974)3.45852472
23Abnormality of the pons (HP:0007361)3.27374503
24Absent forearm bone (HP:0003953)3.26866763
25Aplasia involving forearm bones (HP:0009822)3.26866763
26Chromsome breakage (HP:0040012)3.21245340
27Medulloblastoma (HP:0002885)3.20323045
28Astrocytoma (HP:0009592)3.18392145
29Abnormality of the astrocytes (HP:0100707)3.18392145
30Agnosia (HP:0010524)3.12396157
31Chromosomal breakage induced by crosslinking agents (HP:0003221)3.12168376
32Tubular atrophy (HP:0000092)3.11218714
33Selective tooth agenesis (HP:0001592)3.09973956
34Patellar aplasia (HP:0006443)3.03086614
35Progressive sensorineural hearing impairment (HP:0000408)3.02687167
36Bronchomalacia (HP:0002780)2.98507868
37Mesangial abnormality (HP:0001966)2.97290577
38Chronic otitis media (HP:0000389)2.95745833
39Supernumerary spleens (HP:0009799)2.91864234
40Progressive microcephaly (HP:0000253)2.90643642
41Impulsivity (HP:0100710)2.86002784
42Aplasia/Hypoplasia of the patella (HP:0006498)2.80714009
43Retinal dysplasia (HP:0007973)2.80287189
44Carpal bone hypoplasia (HP:0001498)2.78832317
45CNS hypomyelination (HP:0003429)2.78761210
46Rhabdomyosarcoma (HP:0002859)2.76122183
47Abnormal sex determination (HP:0012244)2.69438467
48Sex reversal (HP:0012245)2.69438467
49Medial flaring of the eyebrow (HP:0010747)2.68800096
50Abnormality of glycolysis (HP:0004366)2.66083447
51Increased serum pyruvate (HP:0003542)2.66083447
52Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.65965916
53Neoplasm of the oral cavity (HP:0100649)2.65677058
54Pancreatic cysts (HP:0001737)2.60412330
55Aplasia/hypoplasia of the humerus (HP:0006507)2.58745445
56Nephronophthisis (HP:0000090)2.58703539
57Rectovaginal fistula (HP:0000143)2.56004368
58Rectal fistula (HP:0100590)2.56004368
59Pancreatic fibrosis (HP:0100732)2.54853179
60Nasal polyposis (HP:0100582)2.53857313
61Premature ovarian failure (HP:0008209)2.53518116
62Oral leukoplakia (HP:0002745)2.53448938
63Global brain atrophy (HP:0002283)2.52855148
64Morphological abnormality of the middle ear (HP:0008609)2.52543631
65Lissencephaly (HP:0001339)2.52323755
66Glioma (HP:0009733)2.52168529
67Absent thumb (HP:0009777)2.49566746
68Abnormal number of incisors (HP:0011064)2.48824467
69Abnormality of cells of the erythroid lineage (HP:0012130)2.45381513
70Abnormality of the anterior horn cell (HP:0006802)2.45290044
71Degeneration of anterior horn cells (HP:0002398)2.45290044
72Abnormality of chromosome stability (HP:0003220)2.44982344
73Reticulocytopenia (HP:0001896)2.43996836
74Premature graying of hair (HP:0002216)2.42122779
75Abnormality of the preputium (HP:0100587)2.41305761
76Rough bone trabeculation (HP:0100670)2.40420854
77Chronic hepatic failure (HP:0100626)2.40079757
78Rib fusion (HP:0000902)2.40056970
79Hypoplastic ilia (HP:0000946)2.38799803
80Short humerus (HP:0005792)2.36420909
81Disproportionate short-trunk short stature (HP:0003521)2.34716661
82Esophageal atresia (HP:0002032)2.34524229
83Abnormality of the ileum (HP:0001549)2.32981647
84Basal cell carcinoma (HP:0002671)2.32443553
85Testicular atrophy (HP:0000029)2.31066907
86Abnormality of the lower motor neuron (HP:0002366)2.30976671
87Neoplasm of striated muscle (HP:0009728)2.30505248
88Meckel diverticulum (HP:0002245)2.29498237
89Asplenia (HP:0001746)2.29212435
90Chronic sinusitis (HP:0011109)2.27603796
91Bronchiectasis (HP:0002110)2.27481378
92Horseshoe kidney (HP:0000085)2.25650012
93Abnormal number of erythroid precursors (HP:0012131)2.24885287
94Colon cancer (HP:0003003)2.24810894
95Duplicated collecting system (HP:0000081)2.23409197
96Hypoplasia of the capital femoral epiphysis (HP:0003090)2.23369225
97Aplasia/Hypoplasia of the uvula (HP:0010293)2.21438221
98Aplasia/Hypoplasia of the spleen (HP:0010451)2.21406788
99Stenosis of the external auditory canal (HP:0000402)2.20909088
100Abnormality of the nasal mucosa (HP:0000433)2.20676278
101Severe muscular hypotonia (HP:0006829)2.19906881
102Abnormality of the salivary glands (HP:0010286)2.19349444
103Abnormality of abdominal situs (HP:0011620)2.19072590
104Abdominal situs inversus (HP:0003363)2.19072590
105Atrophy/Degeneration involving motor neurons (HP:0007373)2.19052405
106Intestinal fistula (HP:0100819)2.18250538
107Multiple enchondromatosis (HP:0005701)2.14718365
108Degeneration of the lateral corticospinal tracts (HP:0002314)2.09596103
109Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.09596103
110Personality changes (HP:0000751)2.08517961
111Facial hemangioma (HP:0000329)2.08228754
112Abnormality of the renal medulla (HP:0100957)2.08146062
113Male pseudohermaphroditism (HP:0000037)2.07774402
114Polydipsia (HP:0001959)2.07586330
115Abnormal drinking behavior (HP:0030082)2.07586330
116Abnormality of the wing of the ilium (HP:0011867)2.06865562
117Sloping forehead (HP:0000340)2.06777807
118Abnormality of DNA repair (HP:0003254)2.05254768
119Delusions (HP:0000746)2.04669745
120Amyotrophic lateral sclerosis (HP:0007354)2.02793039
121Hip dysplasia (HP:0001385)2.02592467
122Chronic bronchitis (HP:0004469)2.02208211
123Progressive hearing impairment (HP:0001730)2.02124275
124Aplasia/Hypoplasia of the sternum (HP:0006714)2.01661639
125Vaginal fistula (HP:0004320)2.01140299
126Bone marrow hypocellularity (HP:0005528)2.00419219
127Small intestinal stenosis (HP:0012848)1.99255813
128Duodenal stenosis (HP:0100867)1.99255813
129Abnormal lung lobation (HP:0002101)1.98553676
130Abnormality of the carotid arteries (HP:0005344)1.98464395
131Squamous cell carcinoma (HP:0002860)1.96966151
132Macrocytic anemia (HP:0001972)1.96836213
133Pendular nystagmus (HP:0012043)1.96658153
134Trismus (HP:0000211)1.95669716
135Thin ribs (HP:0000883)1.95358630
136Cafe-au-lait spot (HP:0000957)1.95054098
137Congenital stationary night blindness (HP:0007642)1.94988108
138Hypoplastic pelvis (HP:0008839)1.93433621
139Abnormal albumin level (HP:0012116)1.92849895
140Hypoalbuminemia (HP:0003073)1.92849895
141Infertility (HP:0000789)1.88808368
142Breast aplasia (HP:0100783)1.88739391
143Morphological abnormality of the inner ear (HP:0011390)1.88717244
144Missing ribs (HP:0000921)1.88496375
145Cystic liver disease (HP:0006706)1.88086471
146Abnormality of the renal cortex (HP:0011035)1.87375297
147Sclerocornea (HP:0000647)1.87335703
148Myelodysplasia (HP:0002863)1.86966549
149Abnormality of cochlea (HP:0000375)1.86735718
150Secondary amenorrhea (HP:0000869)1.86679433
151Gait imbalance (HP:0002141)1.85531274
152Hypoplasia of the odontoid process (HP:0003311)1.85023141
153Abnormality of the corticospinal tract (HP:0002492)1.84660627
154Abnormality of the clitoris (HP:0000056)1.84171946
155Shawl scrotum (HP:0000049)1.84120229
156Neoplasm of the pancreas (HP:0002894)1.83632670
157Diaphragmatic weakness (HP:0009113)1.83488210
158Progressive inability to walk (HP:0002505)1.82673792
159Congenital hepatic fibrosis (HP:0002612)1.81904264
160Trigonocephaly (HP:0000243)1.81779511
161Triphalangeal thumb (HP:0001199)1.79091211
162Neonatal short-limb short stature (HP:0008921)1.78822406
163Congenital primary aphakia (HP:0007707)1.78331835
164Proximal placement of thumb (HP:0009623)1.78245310
165Aplasia/Hypoplasia of the breasts (HP:0010311)1.77393126
166Inability to walk (HP:0002540)1.77175694
167Gastrointestinal atresia (HP:0002589)1.75989192
168Abnormality of the duodenum (HP:0002246)1.75607988
169Postnatal microcephaly (HP:0005484)1.75431313
170Atresia of the external auditory canal (HP:0000413)1.74987310
171Increased neuronal autofluorescent lipopigment (HP:0002074)1.74434778
172Increased CSF lactate (HP:0002490)1.71815194
173Poor head control (HP:0002421)1.71455834
174Nephrogenic diabetes insipidus (HP:0009806)1.69366828
175Optic nerve coloboma (HP:0000588)1.68582529
176Elfin facies (HP:0004428)1.67460291
177Hypoplasia of the brainstem (HP:0002365)1.66935832
178Aplasia/Hypoplasia of the brainstem (HP:0007362)1.66935832
179Holoprosencephaly (HP:0001360)1.65429149
180Acute necrotizing encephalopathy (HP:0006965)1.64907364
181Cerebellar hypoplasia (HP:0001321)1.63561458
182Optic nerve hypoplasia (HP:0000609)1.63433606
183Anencephaly (HP:0002323)1.62250022

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK16.21671318
2BUB14.64763162
3WEE14.37750639
4CDC74.21436895
5ZAK4.17860116
6MAPK153.97181493
7TSSK63.40770900
8PNCK3.14646936
9TTK2.61692250
10SRPK12.40982500
11EIF2AK12.30301259
12CDK122.17638398
13PLK12.10097921
14NEK22.05839683
15NEK11.92541974
16EPHA21.90354341
17TESK21.90108976
18MAPKAPK51.84740750
19CDK71.83942298
20TLK11.80831782
21CHEK21.79184923
22PLK31.68222569
23MAPKAPK31.59717827
24DAPK21.57955186
25RPS6KB21.56513788
26AURKA1.52469562
27CAMKK21.50113405
28TIE11.49321173
29AKT31.48619399
30CHEK11.48075431
31ICK1.44094775
32VRK11.43308519
33MAP4K11.42935503
34BRSK21.40115433
35ATR1.38088426
36ALK1.36693584
37PLK41.35116051
38PASK1.33193448
39STK391.30927687
40CDK31.29400613
41VRK21.28695178
42PTK2B1.25043028
43AURKB1.23577248
44STK161.18843062
45TYRO31.18041620
46CAMK1D1.15681921
47MET1.14246939
48SMG11.12938671
49EIF2AK31.12677227
50CAMKK11.12178301
51LATS21.11391442
52STK101.10683285
53MAP3K111.08664256
54MKNK11.08339072
55MAP3K81.07811107
56BRSK11.07018247
57CDK21.05848842
58MELK1.03871015
59CCNB10.98383256
60MAP2K20.98277555
61CDK40.95267433
62TESK10.94562067
63BRD40.93930966
64TAOK30.93539433
65PBK0.93405842
66MAPK130.91353978
67CSNK2A20.91342315
68MST40.88567161
69CSNK1E0.87292732
70UHMK10.87166018
71ATM0.86739865
72KIT0.86013910
73PDK40.84406831
74PDK30.84406831
75PAK10.83053946
76TRIB30.81543482
77CDK10.81480237
78OXSR10.79207318
79STK40.78923864
80DYRK30.78093042
81FGR0.77598920
82DYRK20.77505551
83PRKCI0.76024795
84CSNK1D0.75399573
85EEF2K0.72507269
86MAP3K90.70296879
87NME20.70263280
88TXK0.69502913
89BRAF0.68959665
90CDK11A0.65138241
91CDK150.64535088
92GRK60.64078830
93EIF2AK20.63347088
94ACVR1B0.63087716
95TAF10.62913152
96CSNK2A10.62879781
97CAMK1G0.61950903
98CSNK1G30.60902724
99PAK40.60617349
100MKNK20.60578136
101PRKCG0.59833550
102PDK20.59637175
103CDK180.58213613
104PAK60.58183670
105ADRBK20.57144732
106CDK190.57106988
107NEK60.54969508
108CLK10.54729823
109NUAK10.53792138
110DAPK10.53754168
111CDK140.53672850
112TNK20.53540989
113GRK10.48382917
114PIM10.47788347
115MTOR0.44633599
116WNK40.44274615
117PRKDC0.43592911
118SCYL20.40833104
119GSK3B0.40747886
120STK110.40722622
121CSNK1G10.37752507
122ARAF0.36849754
123RPS6KA50.36536720
124AKT20.36379661
125MAPK140.35650459
126PKN10.35271205
127STK38L0.35063324
128NTRK30.34535237
129BCR0.33001510
130MAPK100.32631913
131PINK10.31684546
132RAF10.31582358
133ERBB40.30542930
134NME10.28967261
135MAP3K100.27534674
136MAPK110.26452042
137CDK80.25411743
138BMX0.24929457
139BMPR1B0.22880961
140MARK30.22073629
141WNK30.22013805
142PRKCQ0.20084099
143FGFR20.19407865
144NLK0.18098138
145SYK0.17536807
146PRKD30.17319313
147RPS6KA10.16392021
148PKN20.16323225
149LIMK10.15938703

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.49518543
2Mismatch repair_Homo sapiens_hsa034304.44692370
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.42558784
4RNA polymerase_Homo sapiens_hsa030203.77273726
5RNA transport_Homo sapiens_hsa030133.46420602
6Spliceosome_Homo sapiens_hsa030403.32545486
7Proteasome_Homo sapiens_hsa030503.22242547
8Ribosome_Homo sapiens_hsa030102.96156392
9Nucleotide excision repair_Homo sapiens_hsa034202.86838803
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.86080105
11One carbon pool by folate_Homo sapiens_hsa006702.85240271
12Homologous recombination_Homo sapiens_hsa034402.77819961
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.77670817
14Base excision repair_Homo sapiens_hsa034102.48533677
15Cell cycle_Homo sapiens_hsa041102.43233918
16Fanconi anemia pathway_Homo sapiens_hsa034602.37998288
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.31359928
18Basal transcription factors_Homo sapiens_hsa030222.21651944
19Non-homologous end-joining_Homo sapiens_hsa034502.20341605
20Pyrimidine metabolism_Homo sapiens_hsa002402.14463183
21mRNA surveillance pathway_Homo sapiens_hsa030152.03399471
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.97359320
23Phototransduction_Homo sapiens_hsa047441.97257981
24RNA degradation_Homo sapiens_hsa030181.85739259
25Butanoate metabolism_Homo sapiens_hsa006501.77843961
26Vitamin B6 metabolism_Homo sapiens_hsa007501.76232347
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.55082220
28Primary immunodeficiency_Homo sapiens_hsa053401.44661470
29Biosynthesis of amino acids_Homo sapiens_hsa012301.43818533
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.38412953
31Oocyte meiosis_Homo sapiens_hsa041141.38335439
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.36489143
33Nitrogen metabolism_Homo sapiens_hsa009101.25330498
34Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.23253676
35Purine metabolism_Homo sapiens_hsa002301.21896016
36Fatty acid biosynthesis_Homo sapiens_hsa000611.20007411
37Huntingtons disease_Homo sapiens_hsa050161.16748705
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.16221645
39Cyanoamino acid metabolism_Homo sapiens_hsa004601.15356349
40p53 signaling pathway_Homo sapiens_hsa041151.11402158
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09456631
42Oxidative phosphorylation_Homo sapiens_hsa001901.06544469
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.06474379
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04489778
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.04431882
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00346185
47Epstein-Barr virus infection_Homo sapiens_hsa051690.99901837
48Morphine addiction_Homo sapiens_hsa050320.99507260
49Legionellosis_Homo sapiens_hsa051340.97437360
50Parkinsons disease_Homo sapiens_hsa050120.96888624
51Systemic lupus erythematosus_Homo sapiens_hsa053220.93046813
52Taste transduction_Homo sapiens_hsa047420.91971906
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90341522
54Estrogen signaling pathway_Homo sapiens_hsa049150.87353710
55GABAergic synapse_Homo sapiens_hsa047270.86435575
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82175545
57Glutamatergic synapse_Homo sapiens_hsa047240.82099116
58Pentose phosphate pathway_Homo sapiens_hsa000300.80019078
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77891590
60Circadian entrainment_Homo sapiens_hsa047130.74471638
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72197998
62beta-Alanine metabolism_Homo sapiens_hsa004100.71805083
63Viral carcinogenesis_Homo sapiens_hsa052030.71160477
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71008375
65Selenocompound metabolism_Homo sapiens_hsa004500.70052361
66Carbon metabolism_Homo sapiens_hsa012000.69555908
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65716000
68Olfactory transduction_Homo sapiens_hsa047400.65437266
69Steroid biosynthesis_Homo sapiens_hsa001000.65150927
70Fructose and mannose metabolism_Homo sapiens_hsa000510.63860301
71Cocaine addiction_Homo sapiens_hsa050300.62951454
72Folate biosynthesis_Homo sapiens_hsa007900.62742899
73Measles_Homo sapiens_hsa051620.61767757
74Glutathione metabolism_Homo sapiens_hsa004800.61338073
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57532556
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57394260
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55064408
78Alcoholism_Homo sapiens_hsa050340.54182391
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52179091
80Arginine and proline metabolism_Homo sapiens_hsa003300.51433176
81MAPK signaling pathway_Homo sapiens_hsa040100.50691703
82Pyruvate metabolism_Homo sapiens_hsa006200.46138566
83Serotonergic synapse_Homo sapiens_hsa047260.45790206
84Peroxisome_Homo sapiens_hsa041460.45688994
85Alzheimers disease_Homo sapiens_hsa050100.45517163
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42037509
87Ether lipid metabolism_Homo sapiens_hsa005650.41417618
88Fatty acid metabolism_Homo sapiens_hsa012120.41284471
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.40496641
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.38314804
91Antigen processing and presentation_Homo sapiens_hsa046120.38137640
92Metabolic pathways_Homo sapiens_hsa011000.37927750
93Amphetamine addiction_Homo sapiens_hsa050310.37549550
94Hippo signaling pathway_Homo sapiens_hsa043900.37294351
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35471584
96MicroRNAs in cancer_Homo sapiens_hsa052060.35081470
97Fatty acid elongation_Homo sapiens_hsa000620.31969361
98Tight junction_Homo sapiens_hsa045300.31823286
99mTOR signaling pathway_Homo sapiens_hsa041500.30589139
100ABC transporters_Homo sapiens_hsa020100.29276569
101Prion diseases_Homo sapiens_hsa050200.28971157
102Hedgehog signaling pathway_Homo sapiens_hsa043400.28450836
103Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.26520189
104N-Glycan biosynthesis_Homo sapiens_hsa005100.26281176
105Ovarian steroidogenesis_Homo sapiens_hsa049130.25799606
106Calcium signaling pathway_Homo sapiens_hsa040200.23773071
107Linoleic acid metabolism_Homo sapiens_hsa005910.23709692
108Protein export_Homo sapiens_hsa030600.23102126
109Bladder cancer_Homo sapiens_hsa052190.23041950
110Basal cell carcinoma_Homo sapiens_hsa052170.22634314
111Cholinergic synapse_Homo sapiens_hsa047250.22290401
112Sulfur relay system_Homo sapiens_hsa041220.21790126
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.21142159
114Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.21039362
115HTLV-I infection_Homo sapiens_hsa051660.19064365
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.18875577
117Regulation of autophagy_Homo sapiens_hsa041400.18408299
118Notch signaling pathway_Homo sapiens_hsa043300.15240877
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.14271243
120TGF-beta signaling pathway_Homo sapiens_hsa043500.14231627
121Thyroid cancer_Homo sapiens_hsa052160.14126921
122Wnt signaling pathway_Homo sapiens_hsa043100.13547435
123Nicotine addiction_Homo sapiens_hsa050330.13431734
124Renal cell carcinoma_Homo sapiens_hsa052110.11676058
125Collecting duct acid secretion_Homo sapiens_hsa049660.11399236
126Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.11284193
127Cardiac muscle contraction_Homo sapiens_hsa042600.10563459
128Tyrosine metabolism_Homo sapiens_hsa003500.10414468
129Galactose metabolism_Homo sapiens_hsa000520.10159782
130Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.09794820
131Herpes simplex infection_Homo sapiens_hsa051680.08933834
132HIF-1 signaling pathway_Homo sapiens_hsa040660.08089598
133Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.07816357
134Lysine degradation_Homo sapiens_hsa003100.07180644
135Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.05667035
136alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.05393930
137Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.02391971
138Colorectal cancer_Homo sapiens_hsa052100.02248993
139Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.00822598
140Pathways in cancer_Homo sapiens_hsa05200-0.0137511
141Prostate cancer_Homo sapiens_hsa05215-0.0103557

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