KTN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an integral membrane protein that is a member of the kinectin protein family. The encoded protein is primarily localized to the endoplasmic reticulum membrane. This protein binds kinesin and may be involved in intracellular organelle motility. This protein also binds translation elongation factor-delta and may be involved in the assembly of the elongation factor-1 complex. Alternate splicing results in multiple transcript variants of this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)5.98522304
2central nervous system myelination (GO:0022010)5.98522304
3nuclear pore complex assembly (GO:0051292)5.92517177
4nuclear pore organization (GO:0006999)5.11890480
5mitotic sister chromatid cohesion (GO:0007064)4.67090806
6myelination (GO:0042552)4.38865552
7ensheathment of neurons (GO:0007272)4.38379987
8axon ensheathment (GO:0008366)4.38379987
9hemidesmosome assembly (GO:0031581)4.27050270
10pore complex assembly (GO:0046931)4.19599909
11negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.00876372
12eye photoreceptor cell differentiation (GO:0001754)3.90845351
13photoreceptor cell differentiation (GO:0046530)3.90845351
14myofibril assembly (GO:0030239)3.84145103
15negative regulation of protein localization to cell surface (GO:2000009)3.76205173
16sarcomere organization (GO:0045214)3.75063964
17mitotic chromosome condensation (GO:0007076)3.74319128
18muscle filament sliding (GO:0030049)3.69206752
19actin-myosin filament sliding (GO:0033275)3.69206752
20cardiac myofibril assembly (GO:0055003)3.67268438
21asymmetric protein localization (GO:0008105)3.64604409
22apical protein localization (GO:0045176)3.64543110
23paraxial mesoderm development (GO:0048339)3.61161336
24regulation of cell communication by electrical coupling (GO:0010649)3.54769872
25regulation of transforming growth factor beta2 production (GO:0032909)3.50486776
26cell adhesion mediated by integrin (GO:0033627)3.50219608
27myelination in peripheral nervous system (GO:0022011)3.47888564
28peripheral nervous system axon ensheathment (GO:0032292)3.47888564
29regulation of RNA export from nucleus (GO:0046831)3.47773828
30negative regulation of potassium ion transmembrane transport (GO:1901380)3.46831773
31actin-mediated cell contraction (GO:0070252)3.43984875
32long-chain fatty acid biosynthetic process (GO:0042759)3.38846937
33regulation of skeletal muscle contraction (GO:0014819)3.29881205
34regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.26380511
35regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.26048422
36retina vasculature morphogenesis in camera-type eye (GO:0061299)3.24325128
37fatty acid elongation (GO:0030497)3.21109153
38regulation of centriole replication (GO:0046599)3.18428603
39positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.18215371
40regulation of relaxation of muscle (GO:1901077)3.17636968
41sarcoplasmic reticulum calcium ion transport (GO:0070296)3.16222063
42hippo signaling (GO:0035329)3.14316127
43response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.13142763
44regulation of actin filament-based movement (GO:1903115)3.13136606
45regulation of cardioblast differentiation (GO:0051890)3.03987707
46notochord development (GO:0030903)3.03450406
47regulation of nucleobase-containing compound transport (GO:0032239)3.00636622
48negative regulation of neurotransmitter secretion (GO:0046929)2.98620357
49cellular response to epinephrine stimulus (GO:0071872)2.97905453
50cell-substrate junction assembly (GO:0007044)2.95497381
51plasma membrane repair (GO:0001778)2.94744423
52creatine metabolic process (GO:0006600)2.92583352
53actomyosin structure organization (GO:0031032)2.92525053
54regulation of mitotic spindle organization (GO:0060236)2.92264261
55regulation of sarcomere organization (GO:0060297)2.88655419
56regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.88316576
57DNA unwinding involved in DNA replication (GO:0006268)2.86326084
58cardiac muscle tissue morphogenesis (GO:0055008)2.84770174
59negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.84211187
60nerve growth factor signaling pathway (GO:0038180)2.84192895
61negative regulation of DNA repair (GO:0045738)2.82415620
62adult heart development (GO:0007512)2.79332049
63regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.79058684
64NLS-bearing protein import into nucleus (GO:0006607)2.78754044
65actin filament-based movement (GO:0030048)2.76401887
66response to redox state (GO:0051775)2.75828538
67myelin maintenance (GO:0043217)2.75153742
68positive regulation of action potential (GO:0045760)2.72665090
69skin morphogenesis (GO:0043589)2.72489566
70response to epinephrine (GO:0071871)2.68283940
71cerebral cortex radially oriented cell migration (GO:0021799)2.67276812
72ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.66286764
73otic vesicle formation (GO:0030916)2.66115717
74negative regulation of keratinocyte proliferation (GO:0010839)2.65273827
75embryonic foregut morphogenesis (GO:0048617)2.64525268
76epithelial cell-cell adhesion (GO:0090136)2.64085033
77muscle tissue morphogenesis (GO:0060415)2.62869793
78astrocyte development (GO:0014002)2.62833886
79limb bud formation (GO:0060174)2.61334046
80COPII vesicle coating (GO:0048208)2.60203561
81positive regulation of neurological system process (GO:0031646)2.59881634
82Golgi transport vesicle coating (GO:0048200)2.59724407
83COPI coating of Golgi vesicle (GO:0048205)2.59724407
84regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.58846230
85regulation of cardiac muscle cell contraction (GO:0086004)2.58490809
86establishment of mitochondrion localization (GO:0051654)2.58078396
87cardiac muscle contraction (GO:0060048)2.57724390
88peptidyl-tyrosine autophosphorylation (GO:0038083)2.56404043
89cardiac muscle cell development (GO:0055013)2.55250852
90sister chromatid segregation (GO:0000819)2.54868994
91cell-substrate adherens junction assembly (GO:0007045)2.54627113
92focal adhesion assembly (GO:0048041)2.54627113
93regulation of striated muscle contraction (GO:0006942)2.53814762
94regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.53055213
95regulation of membrane repolarization (GO:0060306)2.52663309
96negative regulation of neurotransmitter transport (GO:0051589)2.51831989
97gap junction assembly (GO:0016264)2.51798825
98regulation of centrosome duplication (GO:0010824)2.50500483
99regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.50091610
100cardiac cell development (GO:0055006)2.50074805
101substantia nigra development (GO:0021762)2.48191920
102positive regulation of catenin import into nucleus (GO:0035413)2.46964083
103lateral sprouting from an epithelium (GO:0060601)2.46303374
104monoubiquitinated protein deubiquitination (GO:0035520)2.46066317
105cytoplasmic mRNA processing body assembly (GO:0033962)2.44439076
106metaphase plate congression (GO:0051310)2.44320654
107response to inactivity (GO:0014854)2.43548390
108protein localization to chromosome, centromeric region (GO:0071459)2.43519246
109morphogenesis of an epithelial sheet (GO:0002011)2.43378336
110adherens junction assembly (GO:0034333)2.43141635
111striated muscle contraction (GO:0006941)2.43004830
112positive regulation of potassium ion transport (GO:0043268)2.42632706
113mitotic cytokinesis (GO:0000281)2.42488794
114mesodermal cell differentiation (GO:0048333)2.42415754
115regulation of collateral sprouting (GO:0048670)2.41702697
116regulation of centrosome cycle (GO:0046605)2.41309963
117embryonic retina morphogenesis in camera-type eye (GO:0060059)2.39674032
118cellular response to catecholamine stimulus (GO:0071870)2.38178911
119cellular response to monoamine stimulus (GO:0071868)2.38178911
120cytoskeletal anchoring at plasma membrane (GO:0007016)2.38141436
121mitotic metaphase plate congression (GO:0007080)2.36844088
122regulation of glucocorticoid metabolic process (GO:0031943)2.36766408
123dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.35691357
124neuromuscular junction development (GO:0007528)2.35178793
125presynaptic membrane assembly (GO:0097105)2.34943279
126hypotonic response (GO:0006971)2.34893571
127glucocorticoid receptor signaling pathway (GO:0042921)2.33570192
128sister chromatid cohesion (GO:0007062)2.31987574
129positive regulation of oligodendrocyte differentiation (GO:0048714)2.31594905
130presynaptic membrane organization (GO:0097090)2.31409930
131carnitine shuttle (GO:0006853)2.31052419
132glomerular visceral epithelial cell development (GO:0072015)2.31007055
133cytoskeleton-dependent cytokinesis (GO:0061640)2.30485270
134protein localization to kinetochore (GO:0034501)2.29645870
135mitotic sister chromatid segregation (GO:0000070)2.28790689
136regulation of DNA endoreduplication (GO:0032875)2.27979657
137regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.27499581
138transmission of nerve impulse (GO:0019226)2.27192628
139membrane tubulation (GO:0097320)2.26921311
140chromosome condensation (GO:0030261)2.26404826
141ventricular cardiac muscle cell action potential (GO:0086005)2.26264914
142regulation of cardiac muscle contraction (GO:0055117)2.25932756
143regulation of somitogenesis (GO:0014807)2.25847846
144response to muscle activity (GO:0014850)2.25811500
145positive regulation of actin filament depolymerization (GO:0030836)2.25297507
146negative regulation of axon extension (GO:0030517)2.25121017
147Golgi to plasma membrane protein transport (GO:0043001)2.24733598
148skeletal muscle contraction (GO:0003009)2.24405900
149pericardium development (GO:0060039)2.24164677
150glomerular filtration (GO:0003094)2.23477915
151establishment of apical/basal cell polarity (GO:0035089)2.23327809
152positive regulation of osteoblast proliferation (GO:0033690)2.22232613
153desmosome organization (GO:0002934)2.22131112
154bundle of His cell to Purkinje myocyte communication (GO:0086069)2.21827082
155isoprenoid biosynthetic process (GO:0008299)2.21097719
156regulation of calcium ion transmembrane transport (GO:1903169)2.21049086
157regulation of calcium ion transmembrane transporter activity (GO:1901019)2.21049086
158glomerular epithelial cell development (GO:0072310)2.20918853
159glycerophospholipid catabolic process (GO:0046475)2.20773990
160response to monoamine (GO:0071867)2.20202051
161response to catecholamine (GO:0071869)2.20202051
162membrane assembly (GO:0071709)2.19154468
163DNA duplex unwinding (GO:0032508)2.19060229
164peptidyl-lysine dimethylation (GO:0018027)2.18985028
165cellular protein complex localization (GO:0034629)2.18642445
166tight junction assembly (GO:0070830)2.18568691
167regulation of spindle organization (GO:0090224)2.18521634
168interleukin-6-mediated signaling pathway (GO:0070102)2.17968859
169ribosome assembly (GO:0042255)2.17248576
170genitalia morphogenesis (GO:0035112)2.14963589
171cell-cell junction assembly (GO:0007043)2.14862535
172anterior/posterior axis specification, embryo (GO:0008595)2.14199687
173interkinetic nuclear migration (GO:0022027)2.13050225
174regulation of steroid hormone biosynthetic process (GO:0090030)2.13006366
175regulation of establishment of cell polarity (GO:2000114)2.12674047
176negative regulation of anoikis (GO:2000811)2.12451010

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.83647873
2AR_21909140_ChIP-Seq_LNCAP_Human3.70556719
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.35608117
4GBX2_23144817_ChIP-Seq_PC3_Human3.21137199
5* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.84721489
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.83595291
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.79681616
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.71039697
9EP300_21415370_ChIP-Seq_HL-1_Mouse2.36167945
10CLOCK_20551151_ChIP-Seq_293T_Human2.35921317
11EZH2_22144423_ChIP-Seq_EOC_Human2.28329062
12SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.17334701
13FUS_26573619_Chip-Seq_HEK293_Human2.16337586
14ZNF263_19887448_ChIP-Seq_K562_Human2.14602215
15PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.09194210
16CDX2_19796622_ChIP-Seq_MESCs_Mouse2.00724791
17SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.99261250
18SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.99261250
19SALL1_21062744_ChIP-ChIP_HESCs_Human1.99243200
20* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.94858277
21TAF15_26573619_Chip-Seq_HEK293_Human1.92893369
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.90372822
23TP53_16413492_ChIP-PET_HCT116_Human1.88976173
24* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.87264149
25OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.86817908
26JARID2_20064375_ChIP-Seq_MESCs_Mouse1.84374871
27* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.83006734
28EZH2_27304074_Chip-Seq_ESCs_Mouse1.82102500
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.80451839
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80271124
31PPAR_26484153_Chip-Seq_NCI-H1993_Human1.79188572
32E2F4_17652178_ChIP-ChIP_JURKAT_Human1.78072201
33AR_21572438_ChIP-Seq_LNCaP_Human1.77554398
34WT1_19549856_ChIP-ChIP_CCG9911_Human1.73368545
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.72997563
36ZNF217_24962896_ChIP-Seq_MCF-7_Human1.71746993
37KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.70927995
38SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.69849317
39RNF2_18974828_ChIP-Seq_MESCs_Mouse1.69315221
40EZH2_18974828_ChIP-Seq_MESCs_Mouse1.69315221
41BRD4_25478319_ChIP-Seq_HGPS_Human1.69227929
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.69005286
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.68362009
44* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.67840398
45EGR1_19374776_ChIP-ChIP_THP-1_Human1.64655001
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.63078868
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62792802
48ESR1_20079471_ChIP-ChIP_T-47D_Human1.61452857
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.60979873
50* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.58727765
51* CJUN_26792858_Chip-Seq_BT549_Human1.57278299
52ER_23166858_ChIP-Seq_MCF-7_Human1.54334993
53VDR_22108803_ChIP-Seq_LS180_Human1.54050073
54EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.53843961
55SOX9_24532713_ChIP-Seq_HFSC_Mouse1.52519823
56* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.51488171
57RNF2_27304074_Chip-Seq_ESCs_Mouse1.49508034
58SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.49328340
59EED_16625203_ChIP-ChIP_MESCs_Mouse1.47574467
60* EWS_26573619_Chip-Seq_HEK293_Human1.45976286
61SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.44769898
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.44549841
63STAT3_23295773_ChIP-Seq_U87_Human1.44488914
64E2F1_21310950_ChIP-Seq_MCF-7_Human1.43518858
65SMAD4_21799915_ChIP-Seq_A2780_Human1.43285952
66MTF2_20144788_ChIP-Seq_MESCs_Mouse1.43231172
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41072704
68NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.40829344
69STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.39281338
70FOXO3_23340844_ChIP-Seq_DLD1_Human1.38396406
71AHR_22903824_ChIP-Seq_MCF-7_Human1.37138570
72ESR1_21235772_ChIP-Seq_MCF-7_Human1.36684570
73TP63_17297297_ChIP-ChIP_HaCaT_Human1.36546702
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36361937
75EZH2_27294783_Chip-Seq_ESCs_Mouse1.36010730
76* P300_19829295_ChIP-Seq_ESCs_Human1.35477934
77RBPJ_22232070_ChIP-Seq_NCS_Mouse1.35105321
78FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.34845360
79BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34049722
80SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.33805397
81SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.33754678
82PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33747225
83HIF1A_21447827_ChIP-Seq_MCF-7_Human1.33434721
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.31480452
85CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31086534
86ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.30036850
87TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.29926876
88CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.29782605
89TBX20_22080862_ChIP-Seq_HEART_Mouse1.29494725
90TBX20_22328084_ChIP-Seq_HEART_Mouse1.29494725
91TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29247697
92JARID2_20075857_ChIP-Seq_MESCs_Mouse1.28276533
93SMAD_19615063_ChIP-ChIP_OVARY_Human1.27924668
94TCF4_23295773_ChIP-Seq_U87_Human1.25844382
95* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.25486755
96SOX2_27498859_Chip-Seq_STOMACH_Mouse1.25370930
97HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.24776557
98FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.24738577
99ESR2_21235772_ChIP-Seq_MCF-7_Human1.24672160
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24656623
101VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.23782308
102TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23561680
103ISL1_27105846_Chip-Seq_CPCs_Mouse1.21831989
104SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.20456284
105SOX2_21211035_ChIP-Seq_LN229_Gbm1.19235028
106CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.19001108
107ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.18901426
108DROSHA_22980978_ChIP-Seq_HELA_Human1.17912440
109SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.17688163
110CTNNB1_20460455_ChIP-Seq_HCT116_Human1.16523906
111WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16271696
112SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.15803361
113TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15751724
114TCF4_18268006_ChIP-ChIP_LS174T_Human1.15698503
115TP53_18474530_ChIP-ChIP_U2OS_Human1.15664125
116CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15530742
117* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15219565
118PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.15163300
119MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.15150804
120TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14834588
121DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.14363425
122PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14209487
123TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14053499
124RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13712934
125* GATA3_24758297_ChIP-Seq_MCF-7_Human1.12509171
126* FOXA2_19822575_ChIP-Seq_HepG2_Human1.12154085
127ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12090556
128CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.11752261
129RNF2_27304074_Chip-Seq_NSC_Mouse1.11730977
130POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11200231
131TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11200231
132YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10188668
133SUZ12_27294783_Chip-Seq_ESCs_Mouse1.10154474
134* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.09797409
135UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09709451
136CHD1_26751641_Chip-Seq_LNCaP_Human1.09189352
137LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08621916
138TBL1_22424771_ChIP-Seq_293T_Human1.08384799
139GATA4_21415370_ChIP-Seq_HL-1_Mouse1.08132069
140ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.08060004
141P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07367847
142NANOG_18555785_Chip-Seq_ESCs_Mouse1.07362770
143WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07141103
144RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06945048
145SMAD3_21741376_ChIP-Seq_HESCs_Human1.06833909
146POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06600402
147* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06540250
148* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06540250
149TRIM28_21343339_ChIP-Seq_HEK293_Human1.05983231
150* SOX17_20123909_ChIP-Seq_XEN_Mouse1.05391318
151HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.03879040
152ZNF274_21170338_ChIP-Seq_K562_Hela1.03743517
153TP63_23658742_ChIP-Seq_EP156T_Human1.03309752
154PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02965426
155NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.01430545
156GATA6_25053715_ChIP-Seq_YYC3_Human0.99368989
157MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98862323
158CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98105120
159UBF1/2_26484160_Chip-Seq_HMECs_Human0.96917819
160P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95768241
161FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.94455409
162TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94426074
163SOX2_20726797_ChIP-Seq_SW620_Human0.93679996
164FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.91819207
165FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91659418

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003950_abnormal_plasma_membrane3.20413857
2MP0010352_gastrointestinal_tract_polyps3.07884909
3MP0004145_abnormal_muscle_electrophysio2.97514939
4MP0008057_abnormal_DNA_replication2.65052397
5MP0000751_myopathy2.61173979
6MP0004084_abnormal_cardiac_muscle2.55477548
7MP0010234_abnormal_vibrissa_follicle2.53796031
8MP0002877_abnormal_melanocyte_morpholog2.51828902
9MP0004215_abnormal_myocardial_fiber2.45835543
10MP0003705_abnormal_hypodermis_morpholog2.45138603
11MP0003566_abnormal_cell_adhesion2.34501366
12MP0000749_muscle_degeneration2.31528984
13MP0005623_abnormal_meninges_morphology2.30487797
14MP0004036_abnormal_muscle_relaxation2.27447209
15MP0000920_abnormal_myelination2.24157188
16MP0002837_dystrophic_cardiac_calcinosis2.08540516
17MP0004270_analgesia2.02111069
18MP0003890_abnormal_embryonic-extraembry2.02061340
19MP0004087_abnormal_muscle_fiber1.89234553
20MP0003137_abnormal_impulse_conducting1.88783725
21MP0005330_cardiomyopathy1.81705932
22MP0005171_absent_coat_pigmentation1.79924366
23MP0003880_abnormal_central_pattern1.77256928
24MP0000383_abnormal_hair_follicle1.73500221
25MP0001299_abnormal_eye_distance/1.73364852
26MP0000778_abnormal_nervous_system1.69591485
27MP0002106_abnormal_muscle_physiology1.69286503
28MP0010678_abnormal_skin_adnexa1.67543578
29MP0003937_abnormal_limbs/digits/tail_de1.66707576
30MP0005620_abnormal_muscle_contractility1.65896744
31MP0010368_abnormal_lymphatic_system1.65549350
32MP0005076_abnormal_cell_differentiation1.65473629
33MP0000566_synostosis1.64462670
34MP0003136_yellow_coat_color1.60233607
35MP0001346_abnormal_lacrimal_gland1.58122220
36MP0002972_abnormal_cardiac_muscle1.56767155
37MP0004957_abnormal_blastocyst_morpholog1.55190679
38MP0006072_abnormal_retinal_apoptosis1.54677369
39MP0005369_muscle_phenotype1.51479220
40MP0008438_abnormal_cutaneous_collagen1.50844582
41MP0001661_extended_life_span1.50705139
42MP0004484_altered_response_of1.49550564
43MP0001485_abnormal_pinna_reflex1.49383419
44MP0005551_abnormal_eye_electrophysiolog1.47514699
45MP0000747_muscle_weakness1.44314984
46MP0004272_abnormal_basement_membrane1.42897237
47MP0010630_abnormal_cardiac_muscle1.42513952
48MP0002796_impaired_skin_barrier1.40577265
49MP0000759_abnormal_skeletal_muscle1.38297141
50MP0004085_abnormal_heartbeat1.38193247
51MP0002060_abnormal_skin_morphology1.37896354
52MP0005275_abnormal_skin_tensile1.36635152
53MP0000013_abnormal_adipose_tissue1.36234225
54MP0003984_embryonic_growth_retardation1.34923272
55MP0004885_abnormal_endolymph1.34429508
56MP0003868_abnormal_feces_composition1.34103460
57MP0000733_abnormal_muscle_development1.33792577
58MP0006138_congestive_heart_failure1.33273689
59MP0003091_abnormal_cell_migration1.33170914
60MP0000750_abnormal_muscle_regeneration1.31258828
61MP0002088_abnormal_embryonic_growth/wei1.30923544
62MP0008775_abnormal_heart_ventricle1.30822544
63MP0001672_abnormal_embryogenesis/_devel1.30415767
64MP0005380_embryogenesis_phenotype1.30415767
65MP0003941_abnormal_skin_development1.30384445
66MP0001348_abnormal_lacrimal_gland1.29814937
67MP0009697_abnormal_copulation1.28649880
68MP0002084_abnormal_developmental_patter1.28343005
69MP0003646_muscle_fatigue1.28236832
70MP0004264_abnormal_extraembryonic_tissu1.26564516
71MP0004859_abnormal_synaptic_plasticity1.25899614
72MP0002896_abnormal_bone_mineralization1.24008926
73MP0001730_embryonic_growth_arrest1.23325712
74MP0000428_abnormal_craniofacial_morphol1.22914775
75MP0010094_abnormal_chromosome_stability1.22381819
76MP0004233_abnormal_muscle_weight1.22365959
77MP0004185_abnormal_adipocyte_glucose1.19736764
78MP0003385_abnormal_body_wall1.17731480
79MP0001486_abnormal_startle_reflex1.17088369
80MP0003632_abnormal_nervous_system1.16356984
81MP0003787_abnormal_imprinting1.15637701
82MP0000762_abnormal_tongue_morphology1.15513750
83MP0002269_muscular_atrophy1.14758684
84MP0002272_abnormal_nervous_system1.12561266
85MP0005253_abnormal_eye_physiology1.12444913
86MP0003453_abnormal_keratinocyte_physiol1.12296641
87MP0002086_abnormal_extraembryonic_tissu1.11845693
88MP0004197_abnormal_fetal_growth/weight/1.11394573
89MP0010030_abnormal_orbit_morphology1.10004945
90MP0000462_abnormal_digestive_system1.09634114
91MP0002108_abnormal_muscle_morphology1.09364303
92MP0005666_abnormal_adipose_tissue1.06428389
93MP0003634_abnormal_glial_cell1.06288213
94MP0002697_abnormal_eye_size1.06237264
95MP0005423_abnormal_somatic_nervous1.05345584
96MP0005023_abnormal_wound_healing1.04501741
97MP0008932_abnormal_embryonic_tissue1.04156769
98MP0001697_abnormal_embryo_size1.03997272
99MP0005409_darkened_coat_color1.03698383
100MP0001544_abnormal_cardiovascular_syste1.03244952
101MP0005385_cardiovascular_system_phenoty1.03244952
102MP0000003_abnormal_adipose_tissue1.02618092
103MP0003828_pulmonary_edema1.02084281
104MP0003077_abnormal_cell_cycle1.02037532
105MP0005257_abnormal_intraocular_pressure1.00334857
106MP0002752_abnormal_somatic_nervous1.00029534
107MP0001879_abnormal_lymphatic_vessel0.99059865
108MP0003755_abnormal_palate_morphology0.98785645
109MP0002234_abnormal_pharynx_morphology0.98694031
110MP0009672_abnormal_birth_weight0.98319524
111MP0002882_abnormal_neuron_morphology0.98118329
112MP0001915_intracranial_hemorrhage0.98112080
113MP0003121_genomic_imprinting0.97998523
114MP0004742_abnormal_vestibular_system0.97089346
115MP0005195_abnormal_posterior_eye0.96174522
116MP0002085_abnormal_embryonic_tissue0.95783482
117MP0003690_abnormal_glial_cell0.95205183
118MP0010307_abnormal_tumor_latency0.94651428
119MP0000537_abnormal_urethra_morphology0.93023210
120MP0004134_abnormal_chest_morphology0.92895938
121MP0003111_abnormal_nucleus_morphology0.91903623
122MP0000350_abnormal_cell_proliferation0.91706861
123MP0009250_abnormal_appendicular_skeleto0.91401345
124MP0002229_neurodegeneration0.90965326
125MP0003221_abnormal_cardiomyocyte_apopto0.90397584
126MP0005501_abnormal_skin_physiology0.90337520
127MP0003567_abnormal_fetal_cardiomyocyte0.90032612
128MP0002080_prenatal_lethality0.89991677
129MP0000627_abnormal_mammary_gland0.89048737
130MP0001529_abnormal_vocalization0.88920545
131MP0000579_abnormal_nail_morphology0.88008883
132MP0005375_adipose_tissue_phenotype0.87318507
133MP0009384_cardiac_valve_regurgitation0.87112377
134MP0000647_abnormal_sebaceous_gland0.86667628
135MP0000955_abnormal_spinal_cord0.86568368
136MP0002127_abnormal_cardiovascular_syste0.86533974
137MP0002009_preneoplasia0.85899176
138MP0009703_decreased_birth_body0.85820141
139MP0001216_abnormal_epidermal_layer0.84846226
140MP0000266_abnormal_heart_morphology0.83519707
141MP0002734_abnormal_mechanical_nocicepti0.81064193
142MP0003861_abnormal_nervous_system0.78943938
143MP0003693_abnormal_embryo_hatching0.78684913
144MP0000467_abnormal_esophagus_morphology0.77528001
145MP0003935_abnormal_craniofacial_develop0.76924103
146MP0002233_abnormal_nose_morphology0.72466850
147MP0002332_abnormal_exercise_endurance0.71993220
148MP0003635_abnormal_synaptic_transmissio0.71659421
149MP0009046_muscle_twitch0.71216768
150MP0004130_abnormal_muscle_cell0.71055239
151MP0003122_maternal_imprinting0.71053773
152MP0000432_abnormal_head_morphology0.69226859
153MP0001188_hyperpigmentation0.68269666
154MP0009780_abnormal_chondrocyte_physiolo0.67664473
155MP0002925_abnormal_cardiovascular_devel0.67566915
156MP0009745_abnormal_behavioral_response0.67451639

Predicted human phenotypes

RankGene SetZ-score
1Muscle hypertrophy of the lower extremities (HP:0008968)4.28058129
2Degeneration of the lateral corticospinal tracts (HP:0002314)3.97091431
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.97091431
4Calf muscle hypertrophy (HP:0008981)3.94877999
5Sudden death (HP:0001699)3.74638851
6Muscle fiber splitting (HP:0003555)3.69850199
7Hyporeflexia of lower limbs (HP:0002600)3.68658084
8Abnormality of the calf musculature (HP:0001430)3.31645057
9Atrial fibrillation (HP:0005110)3.25892581
10Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.19323415
11Muscle fiber inclusion bodies (HP:0100299)3.15159776
12Exercise-induced muscle cramps (HP:0003710)3.12232246
13Exercise-induced myalgia (HP:0003738)3.01976755
14Primary atrial arrhythmia (HP:0001692)2.94942612
15Nemaline bodies (HP:0003798)2.92525530
16Ventricular tachycardia (HP:0004756)2.89619809
17Supraventricular tachycardia (HP:0004755)2.75641548
18Difficulty running (HP:0009046)2.75392620
19Arterial tortuosity (HP:0005116)2.72288190
20EMG: myopathic abnormalities (HP:0003458)2.71503275
21Abnormality of the corticospinal tract (HP:0002492)2.71369694
22Supraventricular arrhythmia (HP:0005115)2.71309215
23Hypoplastic ischia (HP:0003175)2.71194349
24Papillary thyroid carcinoma (HP:0002895)2.69966157
25Osteolytic defects of the phalanges of the hand (HP:0009771)2.61950268
26Osteolytic defects of the hand bones (HP:0009699)2.61950268
27Atrophic scars (HP:0001075)2.56100774
28Ankyloglossia (HP:0010296)2.55381738
29Syncope (HP:0001279)2.53224981
30Premature rupture of membranes (HP:0001788)2.52517403
31Prolonged QT interval (HP:0001657)2.49394260
32Abnormality of the ischium (HP:0003174)2.48247435
33Vascular tortuosity (HP:0004948)2.47865825
34Vertebral arch anomaly (HP:0008438)2.47055227
35Flat acetabular roof (HP:0003180)2.46792767
36Scapular winging (HP:0003691)2.44989948
37Right ventricular cardiomyopathy (HP:0011663)2.44847643
38Volvulus (HP:0002580)2.44697903
39Protrusio acetabuli (HP:0003179)2.44029689
40Abnormality of the left ventricular outflow tract (HP:0011103)2.42412698
41Subaortic stenosis (HP:0001682)2.42412698
42Cupped ear (HP:0000378)2.39364397
43Alacrima (HP:0000522)2.38250324
44Parakeratosis (HP:0001036)2.38103068
45Termporal pattern (HP:0011008)2.30657807
46Insidious onset (HP:0003587)2.30657807
47Esophageal atresia (HP:0002032)2.28507520
48Sensory axonal neuropathy (HP:0003390)2.25861490
49Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.15702735
50Missing ribs (HP:0000921)2.15654574
51Short nail (HP:0001799)2.14942803
52Steppage gait (HP:0003376)2.11910664
53Deviation of the thumb (HP:0009603)2.11029544
54Aplasia involving bones of the extremities (HP:0009825)2.10671781
55Aplasia involving bones of the upper limbs (HP:0009823)2.10671781
56Aplasia of the phalanges of the hand (HP:0009802)2.10671781
57Abnormality of the foot musculature (HP:0001436)2.08428911
58Foot dorsiflexor weakness (HP:0009027)2.06142014
59Gowers sign (HP:0003391)2.05856635
60Chin dimple (HP:0010751)2.05041999
61Microglossia (HP:0000171)2.02945210
62Abnormality of oral frenula (HP:0000190)2.02609723
63Lipoatrophy (HP:0100578)2.02461039
64Central scotoma (HP:0000603)2.00980073
65Chromsome breakage (HP:0040012)2.00660152
66Distal lower limb muscle weakness (HP:0009053)2.00294599
67Neck muscle weakness (HP:0000467)1.99848816
68Round ear (HP:0100830)1.98377536
69Hypoplasia of the iris (HP:0007676)1.95324841
70Onion bulb formation (HP:0003383)1.94344176
71Cutaneous finger syndactyly (HP:0010554)1.92926555
72Dilated cardiomyopathy (HP:0001644)1.91815292
73Heterotopia (HP:0002282)1.91556716
74Aplasia cutis congenita (HP:0001057)1.91139867
75Decreased lacrimation (HP:0000633)1.90417887
76Absent frontal sinuses (HP:0002688)1.89391795
77Centrally nucleated skeletal muscle fibers (HP:0003687)1.87004140
78Increased nuchal translucency (HP:0010880)1.85560905
79Dysdiadochokinesis (HP:0002075)1.85456191
80Abnormality of the shoulder girdle musculature (HP:0001435)1.85074971
81Myoglobinuria (HP:0002913)1.84597406
82Type 1 muscle fiber predominance (HP:0003803)1.83360734
83Abnormal auditory evoked potentials (HP:0006958)1.83088629
84Rimmed vacuoles (HP:0003805)1.82325262
85Absent septum pellucidum (HP:0001331)1.81949342
86Distal lower limb amyotrophy (HP:0008944)1.80602214
87Congenital stationary night blindness (HP:0007642)1.80142278
88Limited hip movement (HP:0008800)1.79862516
89Bell-shaped thorax (HP:0001591)1.79335708
90Deep philtrum (HP:0002002)1.78327979
91Myelomeningocele (HP:0002475)1.78160805
92Double outlet right ventricle (HP:0001719)1.77595091
93Congenital malformation of the right heart (HP:0011723)1.77595091
94Mildly elevated creatine phosphokinase (HP:0008180)1.77314878
95Advanced eruption of teeth (HP:0006288)1.76298669
96Limb-girdle muscle atrophy (HP:0003797)1.76212315
97Dysmetria (HP:0001310)1.76167599
98Myotonia (HP:0002486)1.75337903
99Proximal placement of thumb (HP:0009623)1.75203269
100Abnormality of the septum pellucidum (HP:0007375)1.74780958
101Ventricular arrhythmia (HP:0004308)1.73966008
102Fragile skin (HP:0001030)1.73138496
103Aortic dissection (HP:0002647)1.72395485
104Abnormality of the calcaneus (HP:0008364)1.72117714
105Hyperkalemia (HP:0002153)1.72107421
106Knee flexion contracture (HP:0006380)1.71793742
107Spinal rigidity (HP:0003306)1.70277948
108Neurofibrillary tangles (HP:0002185)1.67260719
109Ulnar bowing (HP:0003031)1.66333927
110Hypoalphalipoproteinemia (HP:0003233)1.66064498
111Peripheral hypomyelination (HP:0007182)1.65659316
112Lip pit (HP:0100267)1.65637613
113Broad-based gait (HP:0002136)1.65381442
114Spinal cord lesions (HP:0100561)1.64417773
115Syringomyelia (HP:0003396)1.64417773
116Dysmetric saccades (HP:0000641)1.63786994
117Autoamputation (HP:0001218)1.63751273
118Cutaneous syndactyly (HP:0012725)1.63561359
119Lower limb amyotrophy (HP:0007210)1.63368764
120Abnormality of the distal phalanges of the toes (HP:0010182)1.62900805
121Abnormality of the distal phalanx of the thumb (HP:0009617)1.62726907
122Abnormality of the nasolacrimal system (HP:0000614)1.62592566
123Vertebral clefting (HP:0008428)1.61746289
124Milia (HP:0001056)1.61467724
125Abnormality of the parathyroid morphology (HP:0011766)1.61240846
126Hypoplastic left heart (HP:0004383)1.60466158
127Scanning speech (HP:0002168)1.59840055
128Natal tooth (HP:0000695)1.59519436
129Abnormality of the salivary glands (HP:0010286)1.59237287
130Wormian bones (HP:0002645)1.58917325
131Anteriorly placed anus (HP:0001545)1.58890567
132Cystic hygroma (HP:0000476)1.57782594
133Mixed hearing impairment (HP:0000410)1.57192097
134Selective tooth agenesis (HP:0001592)1.57156465
135Spastic gait (HP:0002064)1.57061506
136Abnormality of the lacrimal duct (HP:0011481)1.57046329
137Hip contracture (HP:0003273)1.56885633
138Abnormality of the acetabulum (HP:0003170)1.56755274
139Chromosomal breakage induced by crosslinking agents (HP:0003221)1.56693850
140Asymmetry of the thorax (HP:0001555)1.56576746
141Distal arthrogryposis (HP:0005684)1.56257302
142Abnormal foot bone ossification (HP:0010675)1.56231107
143Abnormality of the pubic bones (HP:0003172)1.56012756
144Biliary tract neoplasm (HP:0100574)1.55656811
145Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.53628483
146Pterygium (HP:0001059)1.53529692
147Pulmonary artery stenosis (HP:0004415)1.53178318
148Cubitus valgus (HP:0002967)1.53167245
149Relative macrocephaly (HP:0004482)1.52442211
150Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.52379684
151Hypoplastic heart (HP:0001961)1.52179799
152Midline defect of the nose (HP:0004122)1.51632542
153Anophthalmia (HP:0000528)1.51551364
154Mask-like facies (HP:0000298)1.51485127
155Short chin (HP:0000331)1.51387057
156Aortic aneurysm (HP:0004942)1.50561325
157Bundle branch block (HP:0011710)1.50289537
158Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.50165454
159Skin pits (HP:0100276)1.49568373
160Increased connective tissue (HP:0009025)1.49418009
161Rhabdomyolysis (HP:0003201)1.48769955
162Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.48270374
163Breech presentation (HP:0001623)1.48238670
164Overgrowth (HP:0001548)1.47545711
165Back pain (HP:0003418)1.47296938
166Abnormality of the epiphyses of the hand (HP:0005924)1.46893235
167Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.46708322

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.89856863
2MST1R3.80598883
3OBSCN3.13858255
4BCR3.01167053
5SCYL22.83185499
6OXSR12.59565813
7TTN2.45066918
8LATS12.35021515
9WNK12.33824931
10EPHB12.33636591
11LATS22.18926235
12DMPK2.17336249
13PKN12.15310188
14PBK2.03149091
15PHKG22.00037768
16PHKG12.00037768
17WNK41.96608170
18TNIK1.96117430
19PIK3CA1.90712827
20TRPM71.79189115
21NEK11.77113366
22NEK91.76471935
23PRPF4B1.76076085
24FGFR21.74526908
25EIF2AK11.68113011
26EIF2AK31.66802934
27MET1.65950849
28PNCK1.64207343
29EEF2K1.64024030
30BRD41.59575114
31ICK1.53691119
32PAK31.51565147
33PTK21.47020013
34NEK61.46027321
35ROCK21.44198600
36NUAK11.37057238
37CSNK1A1L1.35405056
38CDC71.35256600
39EPHA31.33010735
40CAMK2D1.30226300
41BRSK21.24949052
42EPHA41.22567062
43ACVR1B1.22003665
44PKN21.21193495
45TRIB31.19566007
46RPS6KB21.16932434
47LIMK11.16714568
48MUSK1.16440869
49WEE11.15943831
50TSSK61.13845291
51MST41.09581030
52MKNK11.07524398
53MAP3K21.06641164
54PRKD11.05186270
55NEK21.01623511
56CSNK1G30.96072790
57MTOR0.93966827
58TYRO30.93485297
59RIPK10.92434928
60CAMK2B0.91589559
61PDK20.88387174
62PDGFRB0.87491562
63MYLK0.85275142
64EPHA20.84272176
65ZAK0.83725961
66UHMK10.83703533
67CAMK2A0.83627661
68ROCK10.82820881
69FGR0.81819547
70PAK60.80940294
71PRKCE0.80621562
72CDK60.79901855
73CSNK1G10.78053363
74PAK20.78040342
75CSNK1D0.75747125
76CSNK1G20.75657759
77PLK20.75356565
78CDK80.75286448
79MAP3K90.75106125
80FGFR30.74760299
81FGFR40.74287700
82EPHB20.72546893
83CAMK1G0.71467892
84PAK40.70061865
85SRPK10.67498582
86PLK10.66972253
87FLT30.66602631
88CDC42BPA0.66522684
89MARK10.66427192
90AURKB0.66238020
91PLK40.66218173
92STK380.64180108
93CHEK10.62706521
94GRK70.62689130
95SIK10.62635794
96MAPK130.62563223
97SGK10.60771046
98EIF2AK20.60764181
99CDK120.60228098
100MARK20.59995940
101PRKCQ0.59890362
102SGK2230.59822066
103SGK4940.59822066
104ERBB30.59441744
105MAP3K120.59231790
106MAP3K100.58745506
107LMTK20.58707835
108PRKD20.58580996
109PRKG10.58119723
110CAMK2G0.57920800
111RET0.56850499
112PRKACB0.55338836
113STK38L0.55265882
114KSR10.55221317
115CDK30.54306256
116STK110.54263810
117MAP3K70.54089550
118CDK70.51645384
119ATM0.51349703
120ERBB40.51102808
121MAPKAPK50.50959799
122PRKAA20.50814344
123MAPK100.50610237
124BMPR1B0.49824605
125MKNK20.48731678
126STK30.48568202
127CSNK1E0.48343249
128NTRK10.47883702
129FGFR10.47288230
130PDGFRA0.46729199
131ILK0.46368378
132CASK0.46290715
133CLK10.45302951
134CDK190.45229816
135FER0.45120154
136TAF10.42932380
137CDK50.40270797
138AKT30.39980012
139CDK10.39903115
140TGFBR10.38505957
141RPS6KB10.38187358
142MOS0.37617190
143MELK0.37599714
144PLK30.37171917
145MAPKAPK30.36720991
146STK240.36577044
147PRKDC0.36242657
148RPS6KA50.36169066
149TTK0.36124498
150INSRR0.34380258
151RPS6KA30.34011526
152GSK3B0.32270605
153DYRK20.31951120
154CDK140.30626419

Predicted pathways (KEGG)

RankGene SetZ-score
1Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.71652686
2Dilated cardiomyopathy_Homo sapiens_hsa054142.68104590
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.65247926
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.60756321
5Phototransduction_Homo sapiens_hsa047442.50316068
6Cardiac muscle contraction_Homo sapiens_hsa042602.36218098
7Axon guidance_Homo sapiens_hsa043602.16526637
8Tight junction_Homo sapiens_hsa045302.07193722
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.00161474
10Ether lipid metabolism_Homo sapiens_hsa005651.79000852
11Thyroid cancer_Homo sapiens_hsa052161.76100339
12Fatty acid elongation_Homo sapiens_hsa000621.72507389
13Glutamatergic synapse_Homo sapiens_hsa047241.64259777
14Steroid biosynthesis_Homo sapiens_hsa001001.61691206
15Cell cycle_Homo sapiens_hsa041101.56209940
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.53636471
17ECM-receptor interaction_Homo sapiens_hsa045121.49177425
18Serotonergic synapse_Homo sapiens_hsa047261.49007419
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.48377553
20Central carbon metabolism in cancer_Homo sapiens_hsa052301.38936471
21Renal cell carcinoma_Homo sapiens_hsa052111.38086550
22Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.37048216
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.36271380
24Hippo signaling pathway_Homo sapiens_hsa043901.33913434
25Hedgehog signaling pathway_Homo sapiens_hsa043401.32158969
26Adherens junction_Homo sapiens_hsa045201.32134360
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.30044550
28Pancreatic cancer_Homo sapiens_hsa052121.30016301
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.29435985
30Basal cell carcinoma_Homo sapiens_hsa052171.28639508
31Oxytocin signaling pathway_Homo sapiens_hsa049211.27965117
32Lysine degradation_Homo sapiens_hsa003101.26143853
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.25951314
34Alzheimers disease_Homo sapiens_hsa050101.23845442
35Focal adhesion_Homo sapiens_hsa045101.22712168
36Oxidative phosphorylation_Homo sapiens_hsa001901.22209825
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.21984366
38Pyruvate metabolism_Homo sapiens_hsa006201.20474079
39Circadian entrainment_Homo sapiens_hsa047131.19087827
40Long-term depression_Homo sapiens_hsa047301.18428889
41Vascular smooth muscle contraction_Homo sapiens_hsa042701.17787175
42Chronic myeloid leukemia_Homo sapiens_hsa052201.14917575
43RNA transport_Homo sapiens_hsa030131.14844920
44Morphine addiction_Homo sapiens_hsa050321.14435626
45Propanoate metabolism_Homo sapiens_hsa006401.13670553
46Cholinergic synapse_Homo sapiens_hsa047251.13395130
47cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12832779
48Viral myocarditis_Homo sapiens_hsa054161.11809955
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.11594798
50Wnt signaling pathway_Homo sapiens_hsa043101.10975593
51Nucleotide excision repair_Homo sapiens_hsa034201.10142956
52Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.08693877
53Glucagon signaling pathway_Homo sapiens_hsa049221.08159512
54Endometrial cancer_Homo sapiens_hsa052131.07609804
55Renin secretion_Homo sapiens_hsa049241.07447917
56Insulin signaling pathway_Homo sapiens_hsa049101.05544075
57GABAergic synapse_Homo sapiens_hsa047271.05102058
58Ras signaling pathway_Homo sapiens_hsa040141.05096030
59Mismatch repair_Homo sapiens_hsa034301.04752498
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.04119115
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.03539035
62Parkinsons disease_Homo sapiens_hsa050121.03485155
63Calcium signaling pathway_Homo sapiens_hsa040201.02354022
64ErbB signaling pathway_Homo sapiens_hsa040121.02137686
65TGF-beta signaling pathway_Homo sapiens_hsa043501.00941849
66MicroRNAs in cancer_Homo sapiens_hsa052061.00433650
67Regulation of actin cytoskeleton_Homo sapiens_hsa048101.00312207
68Long-term potentiation_Homo sapiens_hsa047200.99280147
69Sphingolipid metabolism_Homo sapiens_hsa006000.97473819
70Dorso-ventral axis formation_Homo sapiens_hsa043200.96392721
71Gastric acid secretion_Homo sapiens_hsa049710.96045269
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96004581
73Dopaminergic synapse_Homo sapiens_hsa047280.95483880
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94998272
75Proteoglycans in cancer_Homo sapiens_hsa052050.92835722
76Phenylalanine metabolism_Homo sapiens_hsa003600.91403721
77Melanogenesis_Homo sapiens_hsa049160.90330402
78Ovarian steroidogenesis_Homo sapiens_hsa049130.89478989
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88421425
80MAPK signaling pathway_Homo sapiens_hsa040100.87656624
81Arginine biosynthesis_Homo sapiens_hsa002200.86526116
82Colorectal cancer_Homo sapiens_hsa052100.84873527
83Nicotine addiction_Homo sapiens_hsa050330.84830485
84Olfactory transduction_Homo sapiens_hsa047400.84477133
85Carbon metabolism_Homo sapiens_hsa012000.83321124
86Insulin resistance_Homo sapiens_hsa049310.83257655
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.82822071
88Salivary secretion_Homo sapiens_hsa049700.82338823
89cAMP signaling pathway_Homo sapiens_hsa040240.81733146
90Circadian rhythm_Homo sapiens_hsa047100.80847485
91Gap junction_Homo sapiens_hsa045400.79892399
92GnRH signaling pathway_Homo sapiens_hsa049120.79590043
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79511472
94Fatty acid metabolism_Homo sapiens_hsa012120.79399393
95DNA replication_Homo sapiens_hsa030300.78470338
96Taste transduction_Homo sapiens_hsa047420.77487479
97Thyroid hormone synthesis_Homo sapiens_hsa049180.76314726
98AMPK signaling pathway_Homo sapiens_hsa041520.75966099
99PI3K-Akt signaling pathway_Homo sapiens_hsa041510.75533879
100Linoleic acid metabolism_Homo sapiens_hsa005910.74886804
101Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74852644
102Fatty acid degradation_Homo sapiens_hsa000710.74830585
103Rap1 signaling pathway_Homo sapiens_hsa040150.74792219
104mTOR signaling pathway_Homo sapiens_hsa041500.73619410
105Pathways in cancer_Homo sapiens_hsa052000.73358099
106Non-small cell lung cancer_Homo sapiens_hsa052230.72477916
107Choline metabolism in cancer_Homo sapiens_hsa052310.72299367
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.71617587
109Inositol phosphate metabolism_Homo sapiens_hsa005620.70695134
110Huntingtons disease_Homo sapiens_hsa050160.70573625
111Autoimmune thyroid disease_Homo sapiens_hsa053200.70201828
112Fatty acid biosynthesis_Homo sapiens_hsa000610.70007437
113Protein digestion and absorption_Homo sapiens_hsa049740.66266667
114Melanoma_Homo sapiens_hsa052180.66081015
115mRNA surveillance pathway_Homo sapiens_hsa030150.65904705
116Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65190022
117Non-homologous end-joining_Homo sapiens_hsa034500.64735345
118Pancreatic secretion_Homo sapiens_hsa049720.64084120
119Bladder cancer_Homo sapiens_hsa052190.63452890
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.62897367
121Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62862223
122Biosynthesis of amino acids_Homo sapiens_hsa012300.62770883
123Small cell lung cancer_Homo sapiens_hsa052220.62030980
124Type II diabetes mellitus_Homo sapiens_hsa049300.61970224
125Amphetamine addiction_Homo sapiens_hsa050310.61347623
126alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61239151
127Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61229703
128Histidine metabolism_Homo sapiens_hsa003400.60619254
129p53 signaling pathway_Homo sapiens_hsa041150.60483601
130Insulin secretion_Homo sapiens_hsa049110.58187441
131Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56442072
132Prostate cancer_Homo sapiens_hsa052150.56430536
133Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55910773
134Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55764021
135Starch and sucrose metabolism_Homo sapiens_hsa005000.54470532
136Notch signaling pathway_Homo sapiens_hsa043300.53796514
137FoxO signaling pathway_Homo sapiens_hsa040680.53111044
138Endocytosis_Homo sapiens_hsa041440.52807965
139Oocyte meiosis_Homo sapiens_hsa041140.52293603
140Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51308748
141Arginine and proline metabolism_Homo sapiens_hsa003300.50433835
142N-Glycan biosynthesis_Homo sapiens_hsa005100.49889518
143Cysteine and methionine metabolism_Homo sapiens_hsa002700.49681745
144beta-Alanine metabolism_Homo sapiens_hsa004100.49667572
145Vitamin B6 metabolism_Homo sapiens_hsa007500.49558956
146Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49028416
147Estrogen signaling pathway_Homo sapiens_hsa049150.48962797
148Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48898538
149Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48152203
150Pentose phosphate pathway_Homo sapiens_hsa000300.48045902
151Amoebiasis_Homo sapiens_hsa051460.47768371
152Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.47471755
153Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46630031
154Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46274438
155Cocaine addiction_Homo sapiens_hsa050300.46244876
156Glioma_Homo sapiens_hsa052140.44290304
157Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42655609
158Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41296893

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