KRTDAP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which may function in the regulation of keratinocyte differentiation and maintenance of stratified epithelia. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sphingoid metabolic process (GO:0046519)9.40038782
2multicellular organismal water homeostasis (GO:0050891)8.31422262
3keratinization (GO:0031424)8.06888469
4keratinocyte proliferation (GO:0043616)8.01776569
5sphingosine metabolic process (GO:0006670)7.97391219
6regulation of cell proliferation involved in kidney development (GO:1901722)7.28078562
7keratinocyte differentiation (GO:0030216)7.22997834
8diol metabolic process (GO:0034311)7.15180532
9regulation of transforming growth factor beta1 production (GO:0032908)7.04621645
10long-chain fatty acid biosynthetic process (GO:0042759)6.99934066
11positive regulation of interleukin-8 secretion (GO:2000484)6.98746526
12water homeostasis (GO:0030104)6.97999791
13positive regulation of glomerulus development (GO:0090193)6.51406057
14detection of bacterium (GO:0016045)6.48738833
15fatty acid elongation (GO:0030497)6.37563705
16regulation of phospholipase A2 activity (GO:0032429)6.06626207
17interferon-gamma secretion (GO:0072643)5.76839103
18regulation of ruffle assembly (GO:1900027)5.70884846
19epidermal cell differentiation (GO:0009913)5.69227788
20detection of other organism (GO:0098543)5.50815368
21regulation of chemokine secretion (GO:0090196)5.41642458
22intermediate filament cytoskeleton organization (GO:0045104)5.36977657
23glucosamine-containing compound catabolic process (GO:1901072)5.24551856
24linoleic acid metabolic process (GO:0043651)5.22199293
25intermediate filament-based process (GO:0045103)5.20014361
26phosphatidylethanolamine acyl-chain remodeling (GO:0036152)5.13295020
27cyclooxygenase pathway (GO:0019371)5.09354354
28regulation of interleukin-8 secretion (GO:2000482)4.97417849
29G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.84758324
30positive regulation of chemokine secretion (GO:0090197)4.82740057
31chemical homeostasis within a tissue (GO:0048875)4.79996703
32long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.73447675
33hemidesmosome assembly (GO:0031581)4.58037874
34phosphatidylcholine acyl-chain remodeling (GO:0036151)4.55248772
35peptide cross-linking (GO:0018149)4.53519665
36viral transcription (GO:0019083)4.51698906
37bundle of His cell to Purkinje myocyte communication (GO:0086069)4.47206089
38epidermis development (GO:0008544)4.40301131
39prostanoid biosynthetic process (GO:0046457)4.34807919
40prostaglandin biosynthetic process (GO:0001516)4.34807919
41cardiolipin metabolic process (GO:0032048)4.29148825
42lipoxygenase pathway (GO:0019372)4.27892367
43translational termination (GO:0006415)4.27450345
44regulation of glomerulus development (GO:0090192)4.24618520
45gap junction assembly (GO:0016264)4.12853265
46positive regulation of monocyte chemotaxis (GO:0090026)4.09332222
47regulation of hypersensitivity (GO:0002883)4.05154848
48establishment of planar polarity (GO:0001736)4.05028845
49establishment of tissue polarity (GO:0007164)4.05028845
50phosphatidylserine metabolic process (GO:0006658)3.94442999
51fatty-acyl-CoA metabolic process (GO:0035337)3.90818119
52surfactant homeostasis (GO:0043129)3.90601545
53negative regulation of interferon-gamma production (GO:0032689)3.90401383
54retinal metabolic process (GO:0042574)3.86957368
55ceramide biosynthetic process (GO:0046513)3.85473726
56epithelium development (GO:0060429)3.84244023
57regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.78839435
58ribosomal small subunit biogenesis (GO:0042274)3.78559790
59regulation of natural killer cell differentiation (GO:0032823)3.77081060
60negative regulation of stress fiber assembly (GO:0051497)3.76908631
61phospholipid efflux (GO:0033700)3.67708629
62lateral sprouting from an epithelium (GO:0060601)3.64598929
63polarized epithelial cell differentiation (GO:0030859)3.62618997
64epithelial cell differentiation involved in prostate gland development (GO:0060742)3.57677861
65sequestering of metal ion (GO:0051238)3.56808415
66negative regulation of interleukin-17 production (GO:0032700)3.55988223
67positive regulation of T cell chemotaxis (GO:0010820)3.54174737
68regulation of T cell chemotaxis (GO:0010819)3.54174737
69phosphatidylinositol acyl-chain remodeling (GO:0036149)3.53762902
70sphingolipid biosynthetic process (GO:0030148)3.53075445
71prostanoid metabolic process (GO:0006692)3.51279576
72prostaglandin metabolic process (GO:0006693)3.51279576
73phospholipid catabolic process (GO:0009395)3.47280097
74positive regulation of transforming growth factor beta production (GO:0071636)3.47066816
75negative regulation of interleukin-2 production (GO:0032703)3.45991304
76SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.44416144
77glutathione biosynthetic process (GO:0006750)3.43941749
78protein targeting to ER (GO:0045047)3.41135157
79cotranslational protein targeting to membrane (GO:0006613)3.39921206
80phospholipid scrambling (GO:0017121)3.39435567
81viral life cycle (GO:0019058)3.38201930
82hair follicle morphogenesis (GO:0031069)3.37034978
83positive regulation of vesicle fusion (GO:0031340)3.35003133
84establishment of protein localization to endoplasmic reticulum (GO:0072599)3.34795104
85keratinocyte development (GO:0003334)3.34707186
86translational elongation (GO:0006414)3.33844988
87negative regulation of acute inflammatory response (GO:0002674)3.33544804
88regulation of keratinocyte differentiation (GO:0045616)3.31926361
89transepithelial transport (GO:0070633)3.29787927
90negative regulation of kidney development (GO:0090185)3.29687426
91detection of external biotic stimulus (GO:0098581)3.27955167
92positive regulation of cholesterol efflux (GO:0010875)3.26663520
93unsaturated fatty acid biosynthetic process (GO:0006636)3.25309186
94cellular protein complex disassembly (GO:0043624)3.24789648
95defense response to fungus (GO:0050832)3.23671366
96positive regulation of interleukin-4 production (GO:0032753)3.23186380
97protein localization to endoplasmic reticulum (GO:0070972)3.20435743
98intermediate filament organization (GO:0045109)3.19178213
99molting cycle (GO:0042303)3.17404398
100hair cycle (GO:0042633)3.17404398
101primary alcohol catabolic process (GO:0034310)3.17253996
102alditol phosphate metabolic process (GO:0052646)3.16263796
103positive regulation of mitochondrial membrane permeability (GO:0035794)3.15788461
104nonribosomal peptide biosynthetic process (GO:0019184)3.15406152
105ceramide catabolic process (GO:0046514)3.14625839
106gland morphogenesis (GO:0022612)3.11806773
107long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.09306257
108negative regulation of lipase activity (GO:0060192)3.04867872
109ectoderm development (GO:0007398)3.03863954
110positive regulation of epidermal cell differentiation (GO:0045606)3.03640969
111nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.03197976
112eyelid development in camera-type eye (GO:0061029)3.02837893
113chemosensory behavior (GO:0007635)3.02368828
114regulation of monocyte chemotaxis (GO:0090025)3.00184032
115skin morphogenesis (GO:0043589)2.98549696
116positive regulation of sterol transport (GO:0032373)2.97239926
117positive regulation of cholesterol transport (GO:0032376)2.97239926
118phosphatidylserine acyl-chain remodeling (GO:0036150)2.97003959
119negative regulation of T cell mediated immunity (GO:0002710)2.96437351
120positive regulation of epidermis development (GO:0045684)2.95700364
121negative regulation of keratinocyte proliferation (GO:0010839)2.94846669
122phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.90477975
123G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.89929201
124positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.89842726
125very long-chain fatty acid metabolic process (GO:0000038)2.89036501
126regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.87565673
127detection of biotic stimulus (GO:0009595)2.78234366
128defense response to Gram-negative bacterium (GO:0050829)2.75513265
129one-carbon compound transport (GO:0019755)2.73522514
130phosphatidylglycerol metabolic process (GO:0046471)2.65987770
131regulation of keratinocyte proliferation (GO:0010837)2.63876299
132epithelial cell differentiation (GO:0030855)2.62205938
133regulation of neuron projection regeneration (GO:0070570)2.61438886
134regulation of axon regeneration (GO:0048679)2.61438886
135regulation of epidermis development (GO:0045682)2.59291376
136positive regulation of keratinocyte differentiation (GO:0045618)2.57416567
137skin development (GO:0043588)2.56127357
138regulation of epidermal cell differentiation (GO:0045604)2.55333502
139positive regulation of cellular amide metabolic process (GO:0034250)2.54844652
140planar cell polarity pathway involved in neural tube closure (GO:0090179)2.52416481
141polyol transport (GO:0015791)2.51619835
142ventricular cardiac muscle cell action potential (GO:0086005)2.49524300
143response to phenylpropanoid (GO:0080184)2.48580432
144hair cycle process (GO:0022405)2.46581855
145molting cycle process (GO:0022404)2.46581855
146regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.42981212
147retinol metabolic process (GO:0042572)2.38079457
148hair cell differentiation (GO:0035315)2.35856971
149regulation of natural killer cell activation (GO:0032814)2.35787464
150cellular response to antibiotic (GO:0071236)2.27853613
151regulation of protein localization to cell surface (GO:2000008)2.27135164
152intestinal epithelial cell development (GO:0060576)2.25526546
153epithelial cell-cell adhesion (GO:0090136)2.24965571
154atrioventricular valve morphogenesis (GO:0003181)2.22914127
155antimicrobial humoral response (GO:0019730)2.22835124
156epithelial cell proliferation (GO:0050673)2.21581612
157positive regulation of granulocyte chemotaxis (GO:0071624)2.20594774
158fibrinolysis (GO:0042730)2.15361665
159establishment of skin barrier (GO:0061436)13.9412572
160desmosome organization (GO:0002934)13.6768378
161regulation of water loss via skin (GO:0033561)12.4440299

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse6.72164888
2P63_26484246_Chip-Seq_KERATINOCYTES_Human3.33118488
3SOX9_24532713_ChIP-Seq_HFSC_Mouse2.84867368
4STAT6_21828071_ChIP-Seq_BEAS2B_Human2.71737496
5ESR1_21235772_ChIP-Seq_MCF-7_Human2.37832518
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.35259437
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.22278884
8SRY_22984422_ChIP-ChIP_TESTIS_Rat2.19709119
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.10335562
10TP63_17297297_ChIP-ChIP_HaCaT_Human14.6274927
11FOXO3_23340844_ChIP-Seq_DLD1_Human1.99621691
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91667593
13* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.90765938
14TCF4_18268006_ChIP-ChIP_LS174T_Human1.85225602
15SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.79286262
16SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.79286262
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.76616154
18ZNF217_24962896_ChIP-Seq_MCF-7_Human1.72942778
19SOX2_20726797_ChIP-Seq_SW620_Human1.68690604
20ZNF263_19887448_ChIP-Seq_K562_Human1.68221202
21ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.65171942
22TP63_23658742_ChIP-Seq_EP156T_Human1.58734471
23EGR1_19032775_ChIP-ChIP_M12_Human1.53484992
24ERG_20517297_ChIP-Seq_VCAP_Human1.40748284
25TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.36114059
26BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.35958368
27GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.34490289
28TP53_18474530_ChIP-ChIP_U2OS_Human1.33687760
29TP63_22573176_ChIP-Seq_HFKS_Human1.33079592
30GATA4_25053715_ChIP-Seq_YYC3_Human1.28009879
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.27897272
32KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26572801
33BCAT_22108803_ChIP-Seq_LS180_Human1.25407163
34RUNX1_27514584_Chip-Seq_MCF-7_Human1.23650922
35STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19516876
36CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.19430865
37CEBPB_22108803_ChIP-Seq_LS180_Human1.19135360
38CJUN_26792858_Chip-Seq_BT549_Human1.18731053
39GATA6_21074721_ChIP-Seq_CACO-2_Human1.15774881
40BCOR_27268052_Chip-Seq_Bcells_Human1.13528331
41CTCF_20526341_ChIP-Seq_ESCs_Human1.13506823
42KLF5_25053715_ChIP-Seq_YYC3_Human1.11064993
43E2F1_20622854_ChIP-Seq_HELA_Human1.10911937
44RXR_22108803_ChIP-Seq_LS180_Human1.09697314
45VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07814445
46ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07443186
47GATA3_24758297_ChIP-Seq_MCF-7_Human1.05278863
48SMC4_20622854_ChIP-Seq_HELA_Human1.05272231
49TCF4_22108803_ChIP-Seq_LS180_Human1.01534852
50HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97063522
51KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.96559593
52TP53_20018659_ChIP-ChIP_R1E_Mouse0.94991525
53UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.94841921
54CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.93963064
55AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.92943479
56ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91592476
57SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.90768366
58FOXM1_26456572_ChIP-Seq_MCF-7_Human0.90727618
59YY1_22570637_ChIP-Seq_MALME-3M_Human0.89703721
60CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87243450
61CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.87122607
62FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86669564
63* P53_21459846_ChIP-Seq_SAOS-2_Human0.86130228
64AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84469269
65RBPJ_21746931_ChIP-Seq_IB4_Human0.83358744
66CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.83186083
67SA1_27219007_Chip-Seq_Bcells_Human0.82358573
68EED_16625203_ChIP-ChIP_MESCs_Mouse0.82166975
69RARG_19884340_ChIP-ChIP_MEFs_Mouse0.82127790
70TAF2_19829295_ChIP-Seq_ESCs_Human0.81290147
71CDX2_20551321_ChIP-Seq_CACO-2_Human0.80532418
72SUZ12_27294783_Chip-Seq_ESCs_Mouse0.79677835
73FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.79661193
74SOX2_27498859_Chip-Seq_STOMACH_Mouse0.79386152
75UBF1/2_26484160_Chip-Seq_HMECs_Human0.79195902
76HNFA_21074721_ChIP-Seq_CACO-2_Human0.79102926
77BMI1_23680149_ChIP-Seq_NPCS_Mouse0.79061934
78BCL6_27268052_Chip-Seq_Bcells_Human0.79011730
79ATF3_27146783_Chip-Seq_COLON_Human0.78054414
80PPARA_22158963_ChIP-Seq_LIVER_Mouse0.77596641
81GATA3_21867929_ChIP-Seq_TH1_Mouse0.77000938
82SMAD4_21741376_ChIP-Seq_ESCs_Human0.76664139
83GATA6_25053715_ChIP-Seq_YYC3_Human0.76616594
84AR_21572438_ChIP-Seq_LNCaP_Human0.76524197
85BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.76344904
86ESR1_20079471_ChIP-ChIP_T-47D_Human0.76196888
87P68_20966046_ChIP-Seq_HELA_Human0.76159391
88PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.76010079
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.75469231
90SA1_27219007_Chip-Seq_ERYTHROID_Human0.75102333
91EZH2_27304074_Chip-Seq_ESCs_Mouse0.74962605
92SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.74108969
93ARNT_22903824_ChIP-Seq_MCF-7_Human0.73362198
94PPAR_26484153_Chip-Seq_NCI-H1993_Human0.72838142
95CLOCK_20551151_ChIP-Seq_293T_Human0.72519631
96FOXA1_27270436_Chip-Seq_PROSTATE_Human0.72280157
97FOXA1_25329375_ChIP-Seq_VCAP_Human0.72280157
98GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.71774720
99THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.71308990
100FOXA1_21572438_ChIP-Seq_LNCaP_Human0.71214392
101SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.70891284
102* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.70716769
103KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.70092343
104RACK7_27058665_Chip-Seq_MCF-7_Human0.69892654
105AHR_22903824_ChIP-Seq_MCF-7_Human0.69489731
106CTCF_27219007_Chip-Seq_Bcells_Human0.68943061
107EZH2_27294783_Chip-Seq_ESCs_Mouse0.68870080
108IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.68063299
109MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.67994951
110FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.66323390
111GATA2_19941826_ChIP-Seq_K562_Human0.66288096
112P300_27268052_Chip-Seq_Bcells_Human0.66221107
113LXR_22292898_ChIP-Seq_THP-1_Human0.66143504
114PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.65751848
115NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.65682157
116NRF2_20460467_ChIP-Seq_MEFs_Mouse0.65682157
117PHF8_20622853_ChIP-Seq_HELA_Human0.65662494
118RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.65564221
119VDR_22108803_ChIP-Seq_LS180_Human0.65396596
120SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.65213814
121SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.65156164
122JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.64895310
123EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.64830939
124CBX2_22325352_ChIP-Seq_293T-Rex_Human0.64394609
125P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.64352568
126TP53_16413492_ChIP-PET_HCT116_Human0.63592293
127RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.63533047
128JARID2_20075857_ChIP-Seq_MESCs_Mouse0.62703567
129RNF2_27304074_Chip-Seq_ESCs_Mouse0.59819272
130PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.59424095
131DNAJC2_21179169_ChIP-ChIP_NT2_Human0.59365531
132SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.58596378
133JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.58426148
134HTT_18923047_ChIP-ChIP_STHdh_Human0.58336187

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier8.70905406
2MP0003941_abnormal_skin_development7.04952322
3MP0010234_abnormal_vibrissa_follicle6.43635577
4MP0005501_abnormal_skin_physiology5.36609590
5MP0005275_abnormal_skin_tensile4.75360600
6MP0005451_abnormal_body_composition4.61952403
7MP0004381_abnormal_hair_follicle4.30831630
8MP0001216_abnormal_epidermal_layer3.35649852
9MP0002060_abnormal_skin_morphology3.28310242
10MP0010771_integument_phenotype3.20025780
11MP0003453_abnormal_keratinocyte_physiol3.00089453
12MP0004947_skin_inflammation2.86629600
13MP0010678_abnormal_skin_adnexa2.83343808
14MP0002098_abnormal_vibrissa_morphology2.54743226
15MP0002254_reproductive_system_inflammat2.50171748
16MP0001188_hyperpigmentation2.49513227
17MP0000383_abnormal_hair_follicle2.30938455
18MP0003191_abnormal_cellular_cholesterol2.22455041
19MP0000566_synostosis2.18736887
20MP0005377_hearing/vestibular/ear_phenot2.11367354
21MP0003878_abnormal_ear_physiology2.11367354
22MP0000647_abnormal_sebaceous_gland2.05634210
23MP0004185_abnormal_adipocyte_glucose2.05170463
24MP0004885_abnormal_endolymph2.00605788
25MP0005409_darkened_coat_color1.92603930
26MP0000377_abnormal_hair_follicle1.91111019
27MP0000467_abnormal_esophagus_morphology1.84079136
28MP0002009_preneoplasia1.83892980
29MP0009379_abnormal_foot_pigmentation1.82896541
30MP0009931_abnormal_skin_appearance1.70245067
31MP0001191_abnormal_skin_condition1.64952109
32MP0000427_abnormal_hair_cycle1.64738833
33MP0000015_abnormal_ear_pigmentation1.56596200
34MP0004782_abnormal_surfactant_physiolog1.54191542
35MP0008004_abnormal_stomach_pH1.51756772
36MP0000579_abnormal_nail_morphology1.49688231
37MP0003566_abnormal_cell_adhesion1.47052289
38MP0005174_abnormal_tail_pigmentation1.38077465
39MP0010352_gastrointestinal_tract_polyps1.28469463
40MP0000367_abnormal_coat/_hair1.18866682
41MP0001984_abnormal_olfaction1.16435377
42MP0001346_abnormal_lacrimal_gland1.15378015
43MP0001243_abnormal_dermal_layer1.13197463
44MP0000465_gastrointestinal_hemorrhage1.05432675
45MP0001340_abnormal_eyelid_morphology0.99611900
46MP0003011_delayed_dark_adaptation0.94225192
47MP0000762_abnormal_tongue_morphology0.92173294
48MP0003136_yellow_coat_color0.87446981
49MP0001851_eye_inflammation0.77207417
50MP0003950_abnormal_plasma_membrane0.74782422
51MP0006054_spinal_hemorrhage0.67675141
52MP0005076_abnormal_cell_differentiation0.67323755
53MP0003436_decreased_susceptibility_to0.67234948
54MP0002877_abnormal_melanocyte_morpholog0.66449821
55MP0010386_abnormal_urinary_bladder0.66247528
56MP0002090_abnormal_vision0.65721605
57MP0005075_abnormal_melanosome_morpholog0.65522534
58MP0008961_abnormal_basal_metabolism0.64698439
59MP0003638_abnormal_response/metabolism_0.61732835
60MP0005171_absent_coat_pigmentation0.61284564
61MP0001177_atelectasis0.59872237
62MP0005666_abnormal_adipose_tissue0.59552664
63MP0001784_abnormal_fluid_regulation0.58806464
64MP0004019_abnormal_vitamin_homeostasis0.58583854
65MP0005023_abnormal_wound_healing0.57406105
66MP0002006_tumorigenesis0.57054443
67MP0002277_abnormal_respiratory_mucosa0.55654375
68MP0003705_abnormal_hypodermis_morpholog0.54842493
69MP0002177_abnormal_outer_ear0.54037664
70MP0010030_abnormal_orbit_morphology0.48459988
71MP0002166_altered_tumor_susceptibility0.45939792
72MP0002148_abnormal_hypersensitivity_rea0.45567370
73MP0000569_abnormal_digit_pigmentation0.43642629
74MP0000627_abnormal_mammary_gland0.43601701
75MP0000516_abnormal_urinary_system0.42861158
76MP0005367_renal/urinary_system_phenotyp0.42861158
77MP0009780_abnormal_chondrocyte_physiolo0.42847540
78MP0009053_abnormal_anal_canal0.39862437
79MP0003763_abnormal_thymus_physiology0.39063948
80MP0005257_abnormal_intraocular_pressure0.38723203
81MP0001186_pigmentation_phenotype0.37847296
82MP0003938_abnormal_ear_development0.37595203
83MP0003315_abnormal_perineum_morphology0.36021386
84MP0009333_abnormal_splenocyte_physiolog0.35861449
85MP0009384_cardiac_valve_regurgitation0.34289149
86MP0005375_adipose_tissue_phenotype0.33289552
87MP0003329_amyloid_beta_deposits0.32282042
88MP0001666_abnormal_nutrient_absorption0.32159638
89MP0008789_abnormal_olfactory_epithelium0.30106940
90MP0005503_abnormal_tendon_morphology0.29522876
91MP0002095_abnormal_skin_pigmentation0.29026864
92MP0005647_abnormal_sex_gland0.28878363
93MP0002133_abnormal_respiratory_system0.28825750
94MP0005388_respiratory_system_phenotype0.28825750
95MP0004197_abnormal_fetal_growth/weight/0.27467660
96MP0005187_abnormal_penis_morphology0.27442584
97MP0004264_abnormal_extraembryonic_tissu0.27297911
98MP0005408_hypopigmentation0.26860799
99MP0005499_abnormal_olfactory_system0.26730979
100MP0005394_taste/olfaction_phenotype0.26730979
101MP0001765_abnormal_ion_homeostasis0.25745451
102MP0000685_abnormal_immune_system0.24661573
103MP0000538_abnormal_urinary_bladder0.24564340
104MP0002111_abnormal_tail_morphology0.24141237
105MP0003718_maternal_effect0.24016774
106MP0005508_abnormal_skeleton_morphology0.23050245
107MP0000013_abnormal_adipose_tissue0.22790035
108MP0002282_abnormal_trachea_morphology0.21985259
109MP0004858_abnormal_nervous_system0.21978607
110MP0009672_abnormal_birth_weight0.21960614
111MP0003300_gastrointestinal_ulcer0.21899837
112MP0005165_increased_susceptibility_to0.20937067
113MP0000470_abnormal_stomach_morphology0.20135250
114MP0001485_abnormal_pinna_reflex0.20025381
115MP0002736_abnormal_nociception_after0.19892936
116MP0008438_abnormal_cutaneous_collagen0.19294719
117MP0003183_abnormal_peptide_metabolism0.18627082
118MP0005085_abnormal_gallbladder_physiolo0.18292543
119MP0000371_diluted_coat_color0.17941567
120MP0002075_abnormal_coat/hair_pigmentati0.17940574
121MP0002234_abnormal_pharynx_morphology0.16595828
122MP0002132_abnormal_respiratory_system0.15347724
123MP0005390_skeleton_phenotype0.14938152
124MP0000372_irregular_coat_pigmentation0.14802215
125MP0002249_abnormal_larynx_morphology0.14749147
126MP0003755_abnormal_palate_morphology0.14582626
127MP0001533_abnormal_skeleton_physiology0.13482301
128MP0002118_abnormal_lipid_homeostasis0.13103119
129MP0000432_abnormal_head_morphology0.12784169
130MP0002138_abnormal_hepatobiliary_system0.12489210
131MP0001958_emphysema0.11696922
132MP0003828_pulmonary_edema0.10326874
133MP0005193_abnormal_anterior_eye0.10111143
134MP0004043_abnormal_pH_regulation0.10027909
135MP0002233_abnormal_nose_morphology0.09774350
136MP0005248_abnormal_Harderian_gland0.09580724
137MP0000428_abnormal_craniofacial_morphol0.09119469

Predicted human phenotypes

RankGene SetZ-score
1Congenital ichthyosiform erythroderma (HP:0007431)9.99498639
2Parakeratosis (HP:0001036)8.09965211
3Lip pit (HP:0100267)6.64558083
4Alopecia of scalp (HP:0002293)6.37742280
5Hypotrichosis (HP:0001006)6.21799118
6Erythema (HP:0010783)6.15480886
7Thick nail (HP:0001805)5.81887144
8Increased IgE level (HP:0003212)5.71550861
9Woolly hair (HP:0002224)5.63212721
10Erythroderma (HP:0001019)5.58818754
11Oral leukoplakia (HP:0002745)5.40091469
12Right ventricular cardiomyopathy (HP:0011663)5.26550179
13Abnormality of nail color (HP:0100643)5.04239741
14Ectropion (HP:0000656)5.01827052
15Gangrene (HP:0100758)5.00059704
16Abnormality of the axillary hair (HP:0100134)4.81837933
17Abnormality of secondary sexual hair (HP:0009888)4.81837933
18Hypohidrosis (HP:0000966)4.69217421
19Corneal erosion (HP:0200020)4.67892420
20Palmoplantar hyperkeratosis (HP:0000972)4.43441350
21Plantar hyperkeratosis (HP:0007556)4.20929744
22Palmar hyperkeratosis (HP:0010765)4.12676107
23Pruritus (HP:0000989)4.06082046
24Popliteal pterygium (HP:0009756)4.05170416
25Hyporeflexia of lower limbs (HP:0002600)4.02770902
26Sparse scalp hair (HP:0002209)3.96238555
27Curly hair (HP:0002212)3.74239514
28Absent eyelashes (HP:0000561)3.60984988
29Palmoplantar keratoderma (HP:0000982)3.35434137
30Natal tooth (HP:0000695)3.33660499
31Abnormality of the salivary glands (HP:0010286)3.32455147
32Conjunctival hamartoma (HP:0100780)3.26734306
33Lack of skin elasticity (HP:0100679)3.18599995
34Dry skin (HP:0000958)3.17141599
35Absent hair (HP:0002298)3.16400084
36Acanthosis nigricans (HP:0000956)3.13987007
37Severe Myopia (HP:0011003)3.11506792
38Sparse eyelashes (HP:0000653)3.11064473
39Hypoplastic labia majora (HP:0000059)3.07493548
40Areflexia of lower limbs (HP:0002522)3.06686629
41Onycholysis (HP:0001806)3.03487144
42Septate vagina (HP:0001153)3.00431342
43Abnormal blistering of the skin (HP:0008066)2.86653563
44Anhidrosis (HP:0000970)2.85986297
45Follicular hyperkeratosis (HP:0007502)2.84687380
46Advanced eruption of teeth (HP:0006288)2.80113337
47Fragile nails (HP:0001808)2.79963727
48Abnormality of cells of the erythroid lineage (HP:0012130)2.79738083
49Abnormality of the labia majora (HP:0012881)2.79149802
50Distal lower limb muscle weakness (HP:0009053)2.78952421
51Dehydration (HP:0001944)2.76828430
52Ventricular tachycardia (HP:0004756)2.76767395
53Congenital, generalized hypertrichosis (HP:0004540)2.74932485
54Abnormal hemoglobin (HP:0011902)2.58129182
55Furrowed tongue (HP:0000221)2.53733161
56Concave nail (HP:0001598)2.46318737
57Premature ovarian failure (HP:0008209)2.45823815
58Malignant hyperthermia (HP:0002047)2.45681924
59Brittle hair (HP:0002299)2.44066197
60Stenosis of the external auditory canal (HP:0000402)2.39028324
61Pili torti (HP:0003777)2.36880446
62Reticulocytopenia (HP:0001896)2.34083047
63Slow-growing hair (HP:0002217)2.32894429
64Abnormality of hair growth rate (HP:0011363)2.32894429
65Abnormal number of erythroid precursors (HP:0012131)2.27528976
66Oligodontia (HP:0000677)2.21609999
67Ventricular fibrillation (HP:0001663)2.20814220
68Macrocytic anemia (HP:0001972)2.19381734
69Hypoparathyroidism (HP:0000829)2.19046440
70Melanocytic nevus (HP:0000995)2.18716499
71Nail dystrophy (HP:0008404)2.18677228
72Abnormality of placental membranes (HP:0011409)2.16428279
73Amniotic constriction ring (HP:0009775)2.16428279
74Milia (HP:0001056)2.15518203
75Sensory axonal neuropathy (HP:0003390)2.14260319
76Paralysis (HP:0003470)2.10375306
77Ridged nail (HP:0001807)2.10052260
78Abnormality of small intestinal villus morphology (HP:0011472)2.08734066
79Villous atrophy (HP:0011473)2.08734066
80Hyperhidrosis (HP:0000975)2.07597229
81Sepsis (HP:0100806)2.06924114
82Conical tooth (HP:0000698)2.05961727
83Urticaria (HP:0001025)2.02606756
84Labial hypoplasia (HP:0000066)2.02524395
85Congenital nonbullous ichthyosiform erythroderma (HP:0007479)10.2219810
86Abnormality of the gastric mucosa (HP:0004295)1.94781943
87Laryngomalacia (HP:0001601)1.94404509
88Hamartoma (HP:0010566)1.92359511
89Autoamputation (HP:0001218)1.91908759
90Hypoplastic pelvis (HP:0008839)1.90109225
91Pustule (HP:0200039)1.88925305
92Split foot (HP:0001839)1.88693355
93Hypergammaglobulinemia (HP:0010702)1.87249350
94Pterygium (HP:0001059)1.87092961
95Type I diabetes mellitus (HP:0100651)1.86132691
96Down-sloping shoulders (HP:0200021)1.85957052
97Recurrent corneal erosions (HP:0000495)1.85197245
98Hypoplastic female external genitalia (HP:0012815)1.84392399
99Selective tooth agenesis (HP:0001592)1.83672273
100Eczematoid dermatitis (HP:0000976)1.82848490
101Fasciculations (HP:0002380)1.80467022
102Xerostomia (HP:0000217)1.79573802
103Duplicated collecting system (HP:0000081)1.76606817
104Pallor (HP:0000980)1.76327695
105Nasolacrimal duct obstruction (HP:0000579)1.74652925
106Multifactorial inheritance (HP:0001426)1.74436165
107Skin pits (HP:0100276)1.72961262
108Abnormality of the distal phalanges of the toes (HP:0010182)1.70007654
109Chronic bronchitis (HP:0004469)1.67692850
110Absent eyebrow (HP:0002223)1.67552467
111Anonychia (HP:0001798)1.65937150
112Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.65591853
113Abnormality of the dental root (HP:0006486)1.65118391
114Taurodontia (HP:0000679)1.65118391
115Abnormality of permanent molar morphology (HP:0011071)1.65118391
116Neonatal death (HP:0003811)1.63543952
117Fine hair (HP:0002213)1.63387667
118Asthma (HP:0002099)1.61189959
119Intention tremor (HP:0002080)1.60844019
120Ulnar claw (HP:0001178)1.57193530
121Abnormal hair laboratory examination (HP:0003328)1.56835268
122Hamartoma of the eye (HP:0010568)1.56392129
123Hypodontia (HP:0000668)1.56334779
124Abnormality of molar morphology (HP:0011070)1.55894146
125Abnormality of molar (HP:0011077)1.55894146
126Depressed nasal tip (HP:0000437)1.53565719
127Achilles tendon contracture (HP:0001771)1.51242926
128Skin ulcer (HP:0200042)1.49940686
129Abnormality of the renal collecting system (HP:0004742)1.49167038
130Macular degeneration (HP:0000608)1.48570982
131Everted lower lip vermilion (HP:0000232)1.47738090
132Carious teeth (HP:0000670)1.47651449
133Blepharitis (HP:0000498)1.47335098
134Abnormality of the dental pulp (HP:0006479)1.47203717
135Intellectual disability, profound (HP:0002187)1.46520592
136Cupped ear (HP:0000378)1.46508489
137Papilloma (HP:0012740)1.43752628
138Verrucae (HP:0200043)1.43752628
139Corneal dystrophy (HP:0001131)1.43049442
140Dry hair (HP:0011359)1.40920450
141Abnormality of the fingernails (HP:0001231)1.39104762
142Aplasia involving bones of the upper limbs (HP:0009823)1.38090641
143Aplasia of the phalanges of the hand (HP:0009802)1.38090641
144Aplasia involving bones of the extremities (HP:0009825)1.38090641
145Abnormality of the lacrimal duct (HP:0011481)1.35063678

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR15.82376611
2MST44.81836000
3MAPKAPK34.77465005
4MAP3K34.77406354
5MST1R4.55844471
6MAP3K24.07351535
7EPHA23.71833482
8PIM22.99721775
9FER2.49206259
10RPS6KB22.42983169
11TESK12.16816514
12TRPM72.15825578
13SGK4941.94333571
14SGK2231.94333571
15STK101.83833852
16MAPKAPK51.82702074
17MAP3K141.76112066
18STK241.69500836
19ERBB31.62825035
20LRRK21.61667069
21MET1.58045710
22LATS11.57756489
23MAP3K121.55059317
24GRK71.53463258
25PRPF4B1.39549396
26LIMK11.39237141
27MAP3K91.38820075
28BLK1.36754296
29GRK51.36559203
30MAPK71.35288517
31NME21.26876290
32PTK61.24416586
33PIK3CG1.22917063
34TGFBR21.21603932
35NTRK21.21126206
36DYRK1B1.20308788
37ITK1.19091513
38MAPK121.16605934
39EPHB11.16282191
40IRAK11.15828678
41GRK61.15626552
42MAP3K111.05037217
43EPHA41.03903156
44RIPK41.02817579
45PBK1.02176253
46EIF2AK21.02166260
47SRPK10.97387233
48EPHB20.96836004
49MAP2K60.95072286
50MAP3K70.94936813
51SGK20.94293498
52WNK10.93438957
53NLK0.92415166
54EEF2K0.90001943
55FGFR20.89356485
56BCR0.88704804
57CDK120.87925988
58RPS6KB10.87027844
59IRAK30.84901934
60GRK10.84730350
61ERN10.83826379
62STK38L0.82538430
63FGFR10.82297491
64STK30.82073654
65LATS20.81964266
66ADRBK10.81398017
67CDK190.79983925
68SYK0.78771828
69TNK20.75693773
70BMPR1B0.74819246
71SGK30.73679514
72PAK30.73025498
73PTK20.71469416
74FRK0.70640527
75CDK30.69872573
76CDK60.69719514
77ABL20.68921460
78TYRO30.67893938
79PRKD20.67715924
80MAPKAPK20.66958783
81TNIK0.66628498
82MTOR0.66073174
83MAP2K40.65616334
84IKBKB0.65221096
85GSK3A0.64142346
86PRKAA20.63564161
87MOS0.63371276
88KIT0.63124599
89BRAF0.62628123
90ILK0.61490749
91MAP3K50.60170722
92FGFR40.58193057
93CASK0.57878070
94BMPR20.57562078
95CSNK1D0.53873481
96SGK10.52665778
97PRKCE0.52206662
98AKT30.51877282
99FGR0.51661567
100PDGFRA0.50925665
101MAPK150.48040245
102MINK10.47932275
103ROCK10.46474704
104STK110.46315335
105RET0.45782107
106MAP3K10.44690180
107JAK30.44518848
108AURKA0.43260350
109MAP3K60.42084645
110DMPK0.42030469
111TAOK10.41967280
112RIPK10.41200795
113TTK0.41179931
114PDGFRB0.41069737
115PKN10.39925839
116IRAK20.39157983
117ABL10.37742381
118ICK0.35800252
119STK380.35333688
120IKBKE0.35330259
121JAK20.35257806
122SIK10.33505652
123PRKD10.32948489
124ROCK20.32943065
125BRD40.31554579
126EPHA30.31409971
127MARK20.30528405
128TBK10.30308197
129SRC0.29563857
130FGFR30.29553307
131NEK60.28705189
132RPS6KA20.28291309
133KSR20.27384516
134MAPK40.27047542
135STK390.26970795
136PRKCA0.26892302
137TYK20.26716884
138BMX0.26146397
139PRKCQ0.25644775
140TEC0.25035470
141HCK0.24484402
142MAPK90.24171631
143TRIB30.23616875
144PRKCI0.22391175
145HIPK20.22123011
146CDC42BPA0.20602518
147SMG10.18975305
148MAPK110.17650099
149CHUK0.17230772

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004605.38839262
2Sphingolipid metabolism_Homo sapiens_hsa006005.25014106
3Ribosome_Homo sapiens_hsa030103.94957321
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.77788302
5Fatty acid elongation_Homo sapiens_hsa000623.67893798
6Arachidonic acid metabolism_Homo sapiens_hsa005903.36666722
7Linoleic acid metabolism_Homo sapiens_hsa005913.07464834
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.02595046
9Retinol metabolism_Homo sapiens_hsa008302.25572624
10Histidine metabolism_Homo sapiens_hsa003402.22956016
11Ether lipid metabolism_Homo sapiens_hsa005652.09117552
12Phenylalanine metabolism_Homo sapiens_hsa003601.84960440
13ABC transporters_Homo sapiens_hsa020101.71860138
14Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.65482991
15Sphingolipid signaling pathway_Homo sapiens_hsa040711.61174500
16Circadian rhythm_Homo sapiens_hsa047101.48525870
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.47447541
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.35204109
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.34847804
20Tight junction_Homo sapiens_hsa045301.34684718
21Choline metabolism in cancer_Homo sapiens_hsa052311.27536473
22Serotonergic synapse_Homo sapiens_hsa047261.27035739
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.24148096
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.23465876
25Chemical carcinogenesis_Homo sapiens_hsa052041.20841960
26Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20331138
27Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.18294385
28Amoebiasis_Homo sapiens_hsa051461.14574714
29Steroid biosynthesis_Homo sapiens_hsa001001.12305681
30Collecting duct acid secretion_Homo sapiens_hsa049661.10573444
31Tyrosine metabolism_Homo sapiens_hsa003501.07812830
32Glutathione metabolism_Homo sapiens_hsa004801.05174027
33Staphylococcus aureus infection_Homo sapiens_hsa051501.04068947
34VEGF signaling pathway_Homo sapiens_hsa043701.03938931
35Glioma_Homo sapiens_hsa052141.03401636
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.02800816
37Axon guidance_Homo sapiens_hsa043601.01655106
38p53 signaling pathway_Homo sapiens_hsa041150.98915389
39Adherens junction_Homo sapiens_hsa045200.96296820
40Basal cell carcinoma_Homo sapiens_hsa052170.91659132
41Renin secretion_Homo sapiens_hsa049240.90786364
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.89026410
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.85304655
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84786480
45NOD-like receptor signaling pathway_Homo sapiens_hsa046210.81861080
46ECM-receptor interaction_Homo sapiens_hsa045120.81620666
47Pancreatic secretion_Homo sapiens_hsa049720.80898440
48Phospholipase D signaling pathway_Homo sapiens_hsa040720.80225134
49Acute myeloid leukemia_Homo sapiens_hsa052210.79340586
50Fat digestion and absorption_Homo sapiens_hsa049750.74467614
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74187514
52Folate biosynthesis_Homo sapiens_hsa007900.73954556
53Estrogen signaling pathway_Homo sapiens_hsa049150.72120153
54Long-term depression_Homo sapiens_hsa047300.71757327
55Fatty acid biosynthesis_Homo sapiens_hsa000610.71509019
56GnRH signaling pathway_Homo sapiens_hsa049120.69850574
57Mineral absorption_Homo sapiens_hsa049780.69508815
58Hippo signaling pathway_Homo sapiens_hsa043900.66073314
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.65971935
60beta-Alanine metabolism_Homo sapiens_hsa004100.65197140
61Glycerophospholipid metabolism_Homo sapiens_hsa005640.65052583
62Melanogenesis_Homo sapiens_hsa049160.63927864
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63569975
64Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62586794
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.62305921
66Pertussis_Homo sapiens_hsa051330.61669789
67ErbB signaling pathway_Homo sapiens_hsa040120.61390076
68Caffeine metabolism_Homo sapiens_hsa002320.60186932
69Vibrio cholerae infection_Homo sapiens_hsa051100.58149949
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57210664
71Hepatitis C_Homo sapiens_hsa051600.57041094
72Oxidative phosphorylation_Homo sapiens_hsa001900.56694340
73Platelet activation_Homo sapiens_hsa046110.56372506
74Tuberculosis_Homo sapiens_hsa051520.55075474
75Inositol phosphate metabolism_Homo sapiens_hsa005620.52166597
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.51756926
77Ovarian steroidogenesis_Homo sapiens_hsa049130.51381653
78Ras signaling pathway_Homo sapiens_hsa040140.50650762
79Circadian entrainment_Homo sapiens_hsa047130.50323994
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49398734
81MAPK signaling pathway_Homo sapiens_hsa040100.47122047
82Bladder cancer_Homo sapiens_hsa052190.46768710
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46327909
84Notch signaling pathway_Homo sapiens_hsa043300.46010309
85Insulin signaling pathway_Homo sapiens_hsa049100.45441564
86Amphetamine addiction_Homo sapiens_hsa050310.44341178
87Rap1 signaling pathway_Homo sapiens_hsa040150.44127433
88Glutamatergic synapse_Homo sapiens_hsa047240.43868154
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.43166906
90Phototransduction_Homo sapiens_hsa047440.42749653
91Thyroid cancer_Homo sapiens_hsa052160.42374794
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42294521
93Proteoglycans in cancer_Homo sapiens_hsa052050.41551673
94Legionellosis_Homo sapiens_hsa051340.40585014
95Glucagon signaling pathway_Homo sapiens_hsa049220.40204170
96Toxoplasmosis_Homo sapiens_hsa051450.40115935
97Fatty acid degradation_Homo sapiens_hsa000710.39526003
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.39399182
99Gastric acid secretion_Homo sapiens_hsa049710.36457861
100MicroRNAs in cancer_Homo sapiens_hsa052060.35672534
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34530551
102Alzheimers disease_Homo sapiens_hsa050100.33973877
103Renin-angiotensin system_Homo sapiens_hsa046140.33223694
104Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.33068020
105Endocytosis_Homo sapiens_hsa041440.30374483
106Long-term potentiation_Homo sapiens_hsa047200.30236057
107Fatty acid metabolism_Homo sapiens_hsa012120.30031828
108Renal cell carcinoma_Homo sapiens_hsa052110.29244053
109Olfactory transduction_Homo sapiens_hsa047400.28549242
110Arginine biosynthesis_Homo sapiens_hsa002200.28148881
111Protein digestion and absorption_Homo sapiens_hsa049740.28066609
112Salivary secretion_Homo sapiens_hsa049700.27996850
113Vitamin digestion and absorption_Homo sapiens_hsa049770.27069495
114Jak-STAT signaling pathway_Homo sapiens_hsa046300.26922911
115cGMP-PKG signaling pathway_Homo sapiens_hsa040220.26915865
116Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.26705905
117Dopaminergic synapse_Homo sapiens_hsa047280.26542494
118Taste transduction_Homo sapiens_hsa047420.26042945
119Hedgehog signaling pathway_Homo sapiens_hsa043400.25527203
120Influenza A_Homo sapiens_hsa051640.25234446
121Phagosome_Homo sapiens_hsa041450.24219695
122Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.23579468
123Oxytocin signaling pathway_Homo sapiens_hsa049210.22804253
124Salmonella infection_Homo sapiens_hsa051320.22646216
125TGF-beta signaling pathway_Homo sapiens_hsa043500.22264228
126cAMP signaling pathway_Homo sapiens_hsa040240.21984963
127Dorso-ventral axis formation_Homo sapiens_hsa043200.21863730
128PPAR signaling pathway_Homo sapiens_hsa033200.21722396
129Rheumatoid arthritis_Homo sapiens_hsa053230.21577569
130Glycerolipid metabolism_Homo sapiens_hsa005610.21097839
131Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.20907357
132Pathways in cancer_Homo sapiens_hsa052000.20661028
133Calcium signaling pathway_Homo sapiens_hsa040200.19851492
134Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.19579168
135Thyroid hormone signaling pathway_Homo sapiens_hsa049190.18430868
136Peroxisome_Homo sapiens_hsa041460.18184259
137Pancreatic cancer_Homo sapiens_hsa052120.17960138
138African trypanosomiasis_Homo sapiens_hsa051430.17416185
139Wnt signaling pathway_Homo sapiens_hsa043100.17276422
140Complement and coagulation cascades_Homo sapiens_hsa046100.16650145

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