KRTAP5-10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1molting cycle (GO:0042303)8.59079700
2hair cycle (GO:0042633)8.59079700
3central nervous system myelination (GO:0022010)7.45092397
4axon ensheathment in central nervous system (GO:0032291)7.45092397
5viral transcription (GO:0019083)7.38179513
6translational termination (GO:0006415)7.27628674
7ribosomal small subunit assembly (GO:0000028)6.50752225
8maturation of SSU-rRNA (GO:0030490)6.45861235
9viral protein processing (GO:0019082)6.25587202
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.07735754
11ribosomal small subunit biogenesis (GO:0042274)6.01251370
12cotranslational protein targeting to membrane (GO:0006613)5.92972811
13protein targeting to ER (GO:0045047)5.86270669
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.77843570
15L-phenylalanine catabolic process (GO:0006559)5.77843570
16translational elongation (GO:0006414)5.67503869
17virion assembly (GO:0019068)5.63480036
18cellular protein complex disassembly (GO:0043624)5.62496476
19establishment of protein localization to endoplasmic reticulum (GO:0072599)5.57016727
20protein localization to endoplasmic reticulum (GO:0070972)5.53873620
21neuron fate determination (GO:0048664)5.51346650
22nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.41634062
23viral life cycle (GO:0019058)5.38493543
24protein neddylation (GO:0045116)5.29784312
25tyrosine metabolic process (GO:0006570)5.06686664
26protein complex disassembly (GO:0043241)5.05103144
27acrosome assembly (GO:0001675)4.88993785
28L-phenylalanine metabolic process (GO:0006558)4.83300200
29erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.83300200
30positive regulation of cell fate commitment (GO:0010455)4.69930312
31macromolecular complex disassembly (GO:0032984)4.69297753
32male meiosis I (GO:0007141)4.58406889
33behavioral response to nicotine (GO:0035095)4.46004051
34centriole replication (GO:0007099)4.43646755
35positive regulation of transcription from RNA polymerase III promoter (GO:0045945)4.32644832
36protein targeting to membrane (GO:0006612)4.30645351
37energy coupled proton transport, down electrochemical gradient (GO:0015985)4.12709931
38ATP synthesis coupled proton transport (GO:0015986)4.12709931
39translational initiation (GO:0006413)4.07687662
40N-glycan processing (GO:0006491)3.96830494
41protein targeting to Golgi (GO:0000042)3.95177730
42presynaptic membrane assembly (GO:0097105)3.89585218
43seminiferous tubule development (GO:0072520)3.84901188
44axonemal dynein complex assembly (GO:0070286)3.82067176
45hair cell differentiation (GO:0035315)3.81918754
46snRNA transcription (GO:0009301)3.79424407
47negative regulation of cell fate commitment (GO:0010454)3.74030717
48histone H4 deacetylation (GO:0070933)3.73935462
49auditory receptor cell differentiation (GO:0042491)3.72892445
50establishment of protein localization to Golgi (GO:0072600)3.71610792
51positive regulation of protein homooligomerization (GO:0032464)3.69021898
52retrograde transport, vesicle recycling within Golgi (GO:0000301)3.68480445
53regulation of meiosis I (GO:0060631)3.61003484
54alditol metabolic process (GO:0019400)3.59753882
55negative regulation of transcription regulatory region DNA binding (GO:2000678)3.57927414
56negative regulation of glial cell differentiation (GO:0045686)3.56929162
57epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.52619085
58nuclear-transcribed mRNA catabolic process (GO:0000956)3.48276062
59pattern specification involved in kidney development (GO:0061004)3.48117703
60positive regulation of male gonad development (GO:2000020)3.47618407
61middle ear morphogenesis (GO:0042474)3.42928732
62meiosis I (GO:0007127)3.42731064
63protein localization to Golgi apparatus (GO:0034067)3.42689680
64negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.41627672
65negative regulation of DNA repair (GO:0045738)3.40771965
66monoubiquitinated protein deubiquitination (GO:0035520)3.31858118
67mRNA catabolic process (GO:0006402)3.30046749
68glycerol metabolic process (GO:0006071)3.27382449
69histone deubiquitination (GO:0016578)3.27081140
70regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.26661755
71DNA damage response, signal transduction resulting in transcription (GO:0042772)3.26142745
72chemosensory behavior (GO:0007635)3.23049388
73regulation of type B pancreatic cell apoptotic process (GO:2000674)3.20730704
74presynaptic membrane organization (GO:0097090)3.18071287
75mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.17709679
76axoneme assembly (GO:0035082)3.17319026
77intermediate filament organization (GO:0045109)3.16785089
78ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.13994207
79cellular ketone body metabolic process (GO:0046950)3.12287577
80somite rostral/caudal axis specification (GO:0032525)3.11748740
81centriole assembly (GO:0098534)3.10971899
82negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.08828003
83neuronal stem cell maintenance (GO:0097150)3.07644897
84synapsis (GO:0007129)3.00736775
85regulation of translational fidelity (GO:0006450)2.99335730
86dendritic spine morphogenesis (GO:0060997)2.98904214
87negative regulation of JUN kinase activity (GO:0043508)2.98598896
88RNA catabolic process (GO:0006401)2.94207939
89regulation of hydrogen peroxide metabolic process (GO:0010310)2.89621204
90cell proliferation in forebrain (GO:0021846)2.87183585
91negative regulation of transcription by competitive promoter binding (GO:0010944)2.86896795
92male sex determination (GO:0030238)2.85972965
93translation (GO:0006412)2.85943291
94ribosomal large subunit biogenesis (GO:0042273)2.85455254
95spinal cord development (GO:0021510)2.81073839
96positive regulation of gastrulation (GO:2000543)2.80019036
97negative regulation of gliogenesis (GO:0014014)2.79920718
98male meiosis (GO:0007140)2.79215930
99lipid particle organization (GO:0034389)2.79018938
100establishment of protein localization to membrane (GO:0090150)2.78398739

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.44832883
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.76305998
3EZH2_22144423_ChIP-Seq_EOC_Human3.48300334
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.24991760
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.97931432
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.68545515
7TP63_19390658_ChIP-ChIP_HaCaT_Human2.60069954
8ERG_21242973_ChIP-ChIP_JURKAT_Human2.36214697
9CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.29938895
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.15061850
11CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.83450814
12RNF2_27304074_Chip-Seq_ESCs_Mouse1.80520635
13CBX2_27304074_Chip-Seq_ESCs_Mouse1.73293006
14VDR_22108803_ChIP-Seq_LS180_Human1.64978786
15TDRD3_21172665_ChIP-Seq_MCF-7_Human1.57085031
16KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.56737888
17MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.55611275
18EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.51564379
19TP63_17297297_ChIP-ChIP_HaCaT_Human1.51014860
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.50996486
21EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.48822415
22ERG_20517297_ChIP-Seq_VCAP_Human1.48185925
23NANOG_20526341_ChIP-Seq_ESCs_Human1.48077014
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43229254
25ETS1_20019798_ChIP-Seq_JURKAT_Human1.42498942
26ESR1_15608294_ChIP-ChIP_MCF-7_Human1.39285907
27TTF2_22483619_ChIP-Seq_HELA_Human1.38908228
28SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.38344832
29EZH2_27294783_Chip-Seq_ESCs_Mouse1.38308525
30CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.38123275
31ERA_21632823_ChIP-Seq_H3396_Human1.38027130
32RNF2_27304074_Chip-Seq_NSC_Mouse1.37065176
33EZH2_27304074_Chip-Seq_ESCs_Mouse1.34826679
34KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.34043484
35KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.34043484
36KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.34043484
37CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.33518383
38HTT_18923047_ChIP-ChIP_STHdh_Human1.33166110
39TAF2_19829295_ChIP-Seq_ESCs_Human1.32223502
40EGR1_19032775_ChIP-ChIP_M12_Human1.28986860
41ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.25906908
42ZNF274_21170338_ChIP-Seq_K562_Hela1.25565539
43* P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.24813200
44HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22955581
45XRN2_22483619_ChIP-Seq_HELA_Human1.20918711
46POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.20041067
47JARID2_20075857_ChIP-Seq_MESCs_Mouse1.19546700
48IKZF1_21737484_ChIP-ChIP_HCT116_Human1.19244279
49TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18644861
50CTCF_27219007_Chip-Seq_Bcells_Human1.18204597
51E2F7_22180533_ChIP-Seq_HELA_Human1.18110997
52SUZ12_27294783_Chip-Seq_ESCs_Mouse1.17103691
53MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.15441285
54SOX3_22085726_ChIP-Seq_NPCs_Mouse1.11299094
55KDM5A_27292631_Chip-Seq_BREAST_Human1.10675863
56ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10217983
57CTCF_18555785_ChIP-Seq_MESCs_Mouse1.09114743
58KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09078384
59TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.08936816
60P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08846303
61NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.06460122
62* SA1_27219007_Chip-Seq_Bcells_Human1.04737569
63BCL6_27268052_Chip-Seq_Bcells_Human1.04691573
64RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04503328
65ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03383180
66CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.03280594
67TP53_20018659_ChIP-ChIP_R1E_Mouse1.01159185
68OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.00823145
69ELK1_22589737_ChIP-Seq_MCF10A_Human1.00746188
70E2F1_17053090_ChIP-ChIP_MCF-7_Human0.99392700
71E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.98779408
72GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97454820
73CIITA_25753668_ChIP-Seq_RAJI_Human0.97095982
74PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.97007821
75ESR1_20079471_ChIP-ChIP_T-47D_Human0.96125215
76RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95208385
77GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.93129745
78EED_16625203_ChIP-ChIP_MESCs_Mouse0.92977946
79SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.91575998
80NANOG_18555785_ChIP-Seq_MESCs_Mouse0.91411346
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91238082
82CBP_20019798_ChIP-Seq_JUKART_Human0.91238082
83BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90268843
84YY1_21170310_ChIP-Seq_MESCs_Mouse0.89289431
85SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.89128351
86P68_20966046_ChIP-Seq_HELA_Human0.88319143
87DCP1A_22483619_ChIP-Seq_HELA_Human0.87547862
88SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.86909898
89NANOG_19829295_ChIP-Seq_ESCs_Human0.86459530
90SOX2_19829295_ChIP-Seq_ESCs_Human0.86459530
91SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86167739
92TET1_21451524_ChIP-Seq_MESCs_Mouse0.85698513
93EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.85683853
94RUNX1_26923725_Chip-Seq_HPCs_Mouse0.85544813
95JARID2_20064375_ChIP-Seq_MESCs_Mouse0.84841553
96REST_21632747_ChIP-Seq_MESCs_Mouse0.83515436
97PHF8_20622854_ChIP-Seq_HELA_Human0.83021098
98EZH2_18974828_ChIP-Seq_MESCs_Mouse0.82753197
99RNF2_18974828_ChIP-Seq_MESCs_Mouse0.82753197
100SMC4_20622854_ChIP-Seq_HELA_Human0.82201409

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.71092586
2MP0002837_dystrophic_cardiac_calcinosis5.87224988
3MP0003878_abnormal_ear_physiology5.81661196
4MP0005377_hearing/vestibular/ear_phenot5.81661196
5MP0006292_abnormal_olfactory_placode4.29325201
6MP0002653_abnormal_ependyma_morphology3.79590408
7MP0003136_yellow_coat_color3.02928022
8MP0001849_ear_inflammation2.98249443
9MP0003890_abnormal_embryonic-extraembry2.81828740
10MP0010307_abnormal_tumor_latency2.79066843
11MP0001485_abnormal_pinna_reflex2.66705964
12MP0000647_abnormal_sebaceous_gland2.57228886
13MP0008877_abnormal_DNA_methylation2.39886188
14MP0001529_abnormal_vocalization2.31918302
15MP0003183_abnormal_peptide_metabolism2.29694782
16MP0008789_abnormal_olfactory_epithelium2.17358156
17MP0000049_abnormal_middle_ear2.05382510
18MP0003646_muscle_fatigue1.99260914
19MP0005394_taste/olfaction_phenotype1.98462163
20MP0005499_abnormal_olfactory_system1.98462163
21MP0010030_abnormal_orbit_morphology1.96975747
22MP0002938_white_spotting1.84873511
23MP0001293_anophthalmia1.81923871
24MP0002095_abnormal_skin_pigmentation1.81712505
25MP0000566_synostosis1.64978718
26MP0005174_abnormal_tail_pigmentation1.57800428
27MP0000427_abnormal_hair_cycle1.55722767
28MP0002234_abnormal_pharynx_morphology1.49754457
29MP0004270_analgesia1.41962251
30MP0005408_hypopigmentation1.40652948
31MP0003122_maternal_imprinting1.38315678
32MP0001986_abnormal_taste_sensitivity1.35089599
33MP0002098_abnormal_vibrissa_morphology1.34118211
34MP0002282_abnormal_trachea_morphology1.32908402
35MP0000579_abnormal_nail_morphology1.32736815
36MP0004381_abnormal_hair_follicle1.32463481
37MP0003186_abnormal_redox_activity1.28286528
38MP0000013_abnormal_adipose_tissue1.23322712
39MP0004019_abnormal_vitamin_homeostasis1.18552061
40MP0005075_abnormal_melanosome_morpholog1.17458650
41MP0008995_early_reproductive_senescence1.16505800
42MP0000377_abnormal_hair_follicle1.11226576
43MP0008058_abnormal_DNA_repair1.02424779
44MP0001968_abnormal_touch/_nociception0.98729755
45MP0003755_abnormal_palate_morphology0.98572035
46MP0002102_abnormal_ear_morphology0.98304135
47MP0003698_abnormal_male_reproductive0.96236024
48MP0002928_abnormal_bile_duct0.95961334
49MP0004742_abnormal_vestibular_system0.94755469
50MP0001486_abnormal_startle_reflex0.93888363
51MP0001963_abnormal_hearing_physiology0.89926446
52MP0002092_abnormal_eye_morphology0.88950653
53MP0002638_abnormal_pupillary_reflex0.87466006
54MP0002163_abnormal_gland_morphology0.84543008
55MP0009046_muscle_twitch0.83955808
56MP0000778_abnormal_nervous_system0.82714493
57MP0002138_abnormal_hepatobiliary_system0.80430580
58MP0001929_abnormal_gametogenesis0.78681575
59MP0001348_abnormal_lacrimal_gland0.77788646
60MP0002210_abnormal_sex_determination0.76914800
61MP0002295_abnormal_pulmonary_circulatio0.75607563
62MP0003786_premature_aging0.73768820
63MP0005397_hematopoietic_system_phenotyp0.72803090
64MP0001545_abnormal_hematopoietic_system0.72803090
65MP0004885_abnormal_endolymph0.69640538
66MP0005379_endocrine/exocrine_gland_phen0.69341086
67MP0005386_behavior/neurological_phenoty0.65242514
68MP0004924_abnormal_behavior0.65242514
69MP0002233_abnormal_nose_morphology0.64893476
70MP0006276_abnormal_autonomic_nervous0.64210089
71MP0000026_abnormal_inner_ear0.63566726
72MP0005647_abnormal_sex_gland0.62923437
73MP0002697_abnormal_eye_size0.62816889
74MP0001145_abnormal_male_reproductive0.62731823
75MP0002152_abnormal_brain_morphology0.62686593
76MP0003567_abnormal_fetal_cardiomyocyte0.62044479
77MP0005501_abnormal_skin_physiology0.58674875
78MP0002161_abnormal_fertility/fecundity0.58230108
79MP0002751_abnormal_autonomic_nervous0.57794747
80MP0000631_abnormal_neuroendocrine_gland0.56647431
81MP0002572_abnormal_emotion/affect_behav0.55154733
82MP0005275_abnormal_skin_tensile0.54929426
83MP0001324_abnormal_eye_pigmentation0.54049434
84MP0003861_abnormal_nervous_system0.53995583
85MP0000653_abnormal_sex_gland0.53262979
86MP0004133_heterotaxia0.53192644
87MP0003011_delayed_dark_adaptation0.53037214
88MP0005195_abnormal_posterior_eye0.52777633
89MP0000467_abnormal_esophagus_morphology0.52585418
90MP0002063_abnormal_learning/memory/cond0.52328243
91MP0003635_abnormal_synaptic_transmissio0.51428998
92MP0003283_abnormal_digestive_organ0.49501503
93MP0003121_genomic_imprinting0.49368687
94MP0003936_abnormal_reproductive_system0.48879574
95MP0003787_abnormal_imprinting0.48552196
96MP0000367_abnormal_coat/_hair0.47601945
97MP0005391_vision/eye_phenotype0.47343715
98MP0003937_abnormal_limbs/digits/tail_de0.47058905
99MP0005084_abnormal_gallbladder_morpholo0.46030241
100MP0000955_abnormal_spinal_cord0.44894845

Predicted human phenotypes

RankGene SetZ-score
1Increased hepatocellular lipid droplets (HP:0006565)7.63699624
2Lipid accumulation in hepatocytes (HP:0006561)7.01796847
3Increased intramyocellular lipid droplets (HP:0012240)5.71637266
4Renal Fanconi syndrome (HP:0001994)5.64716886
5Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)5.05176735
6Reticulocytopenia (HP:0001896)5.04773563
7Increased muscle lipid content (HP:0009058)4.97079868
8Exertional dyspnea (HP:0002875)4.61278117
9Chromsome breakage (HP:0040012)4.30371459
10Abnormality of DNA repair (HP:0003254)4.09753012
11Respiratory difficulties (HP:0002880)4.09347710
12Abnormality of cells of the erythroid lineage (HP:0012130)4.07740219
13Abdominal situs inversus (HP:0003363)3.77751385
14Abnormality of abdominal situs (HP:0011620)3.77751385
15Abnormality of renal resorption (HP:0011038)3.63422905
16Flat capital femoral epiphysis (HP:0003370)3.56414294
17Genetic anticipation (HP:0003743)3.42639454
18Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.35240150
19Mitochondrial inheritance (HP:0001427)3.34208003
20Brittle hair (HP:0002299)3.34082251
21Abnormal number of erythroid precursors (HP:0012131)3.32727570
22Septo-optic dysplasia (HP:0100842)3.30199868
23Entropion (HP:0000621)3.29069992
2411 pairs of ribs (HP:0000878)3.12153478
25Woolly hair (HP:0002224)3.10521484
26High anterior hairline (HP:0009890)3.08117720
27Pili torti (HP:0003777)2.98597125
28Onycholysis (HP:0001806)2.98247839
29Pendular nystagmus (HP:0012043)2.94196095
30Pancreatic fibrosis (HP:0100732)2.92696822
31Increased CSF lactate (HP:0002490)2.92119879
32Hyperphosphaturia (HP:0003109)2.91596919
33Abnormal delayed hypersensitivity skin test (HP:0002963)2.84275449
34True hermaphroditism (HP:0010459)2.78348246
35Macrocytic anemia (HP:0001972)2.74796963
36Progressive cerebellar ataxia (HP:0002073)2.70407157
37Chronic mucocutaneous candidiasis (HP:0002728)2.69150556
38Recurrent cutaneous fungal infections (HP:0011370)2.69150556
39Abnormality of hair growth rate (HP:0011363)2.61402866
40Slow-growing hair (HP:0002217)2.61402866
41Colon cancer (HP:0003003)2.59424263
42Chromosomal breakage induced by crosslinking agents (HP:0003221)2.57049182
43Cystic liver disease (HP:0006706)2.52033247
44Fragile nails (HP:0001808)2.48654663
45Molar tooth sign on MRI (HP:0002419)2.47090859
46Abnormality of midbrain morphology (HP:0002418)2.47090859
47Nuclear cataract (HP:0100018)2.43266151
48Absent septum pellucidum (HP:0001331)2.41062378
49Slow saccadic eye movements (HP:0000514)2.37956871
50Missing ribs (HP:0000921)2.33944986
51Pallor (HP:0000980)2.33761039
52Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.33213921
53Glycosuria (HP:0003076)2.32145184
54Abnormality of urine glucose concentration (HP:0011016)2.32145184
55Absent thumb (HP:0009777)2.31580595
56Pancreatic cysts (HP:0001737)2.31475917
57Abnormal urine phosphate concentration (HP:0012599)2.29245707
58Sclerocornea (HP:0000647)2.25384971
59Panhypogammaglobulinemia (HP:0003139)2.25185835
60Poikiloderma (HP:0001029)2.24484746
61Acute necrotizing encephalopathy (HP:0006965)2.23479978
62Type II lissencephaly (HP:0007260)2.23024488
63Broad alveolar ridges (HP:0000187)2.15253833
64Long foot (HP:0001833)2.14939512
65Anterior segment dysgenesis (HP:0007700)2.14504283
66Aplasia/Hypoplasia of the uvula (HP:0010293)2.14459508
67Nephronophthisis (HP:0000090)2.13141401
68Duplicated collecting system (HP:0000081)2.10989058
69Testicular atrophy (HP:0000029)2.02589556
70Hypotrichosis (HP:0001006)2.00532928
71Hepatocellular necrosis (HP:0001404)2.00319602
72Maternal diabetes (HP:0009800)1.99611253
73Abnormality of the renal medulla (HP:0100957)1.95542535
74Hydroureter (HP:0000072)1.94419768
75Flared iliac wings (HP:0002869)1.93911163
76Abnormal mitochondria in muscle tissue (HP:0008316)1.93215971
77Abnormality of the renal collecting system (HP:0004742)1.91747638
78Abnormal biliary tract physiology (HP:0012439)1.91019323
79Bile duct proliferation (HP:0001408)1.91019323
80Abnormality of the ileum (HP:0001549)1.90719146
81Congenital ichthyosiform erythroderma (HP:0007431)1.89495743
82Aplasia/Hypoplasia of the tongue (HP:0010295)1.88526392
83Ulnar deviation of the wrist (HP:0003049)1.88428451
84Villous atrophy (HP:0011473)1.87772848
85Abnormality of small intestinal villus morphology (HP:0011472)1.87772848
86Asplenia (HP:0001746)1.85699902
87Scrotal hypoplasia (HP:0000046)1.85515191
88Renal tubular dysfunction (HP:0000124)1.85268427
89Erythroderma (HP:0001019)1.84159685
90Depressed nasal ridge (HP:0000457)1.84003750
91Hepatic necrosis (HP:0002605)1.83779595
92Exercise intolerance (HP:0003546)1.80998098
93Occipital encephalocele (HP:0002085)1.80840573
94Pigmentary retinal degeneration (HP:0001146)1.79186410
95Acute encephalopathy (HP:0006846)1.78234378
96Abnormality of the preputium (HP:0100587)1.77699987
97Cerebellar dysplasia (HP:0007033)1.77241982
98Decreased muscle mass (HP:0003199)1.75721363
99Increased serum lactate (HP:0002151)1.74018288
100Meckel diverticulum (HP:0002245)1.73254077

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK44.55907093
2CDK194.20414883
3EPHB24.18067100
4STK393.83121331
5PAK33.27832456
6PINK13.22394924
7CASK2.49860958
8MAPK152.34747982
9OXSR12.29933123
10NTRK12.15560034
11TIE12.12036356
12MYLK2.10308087
13STK162.09174154
14MAP3K102.03833129
15DMPK1.98895558
16WNK11.98531907
17RPS6KL11.74797329
18RPS6KC11.74797329
19RPS6KA61.69266724
20WNK31.67230284
21DYRK31.65507816
22IRAK11.64009425
23MAP2K31.63665298
24NTRK21.53343568
25MAP2K41.52290779
26RPS6KA41.51341744
27PRKD31.40565564
28LRRK21.33463768
29CAMK41.22895302
30MAP2K61.21572350
31STK41.14468271
32STK111.11600125
33CAMKK21.10853326
34SGK21.05821802
35MAP2K21.04690356
36RIPK11.03649961
37IKBKE1.00657405
38MAPK110.98674965
39HIPK20.97916854
40MARK20.97142158
41DYRK1B0.94370969
42SGK2230.93773551
43SGK4940.93773551
44PIM20.93567158
45RPS6KA20.92216900
46CAMK10.84766849
47MAP3K80.84541156
48CAMK2D0.83853989
49MAPK70.81178815
50MAP3K70.79391727
51EPHA40.79001912
52TYK20.78104037
53CAMKK10.74948028
54PNCK0.72073628
55PIK3CA0.70450927
56CAMK1D0.69924822
57ROCK20.67576105
58PRKCG0.64449803
59MAPK120.62861673
60PRKCQ0.62350112
61ABL20.58572423
62CDK40.57441912
63DYRK20.56649908
64CAMK2G0.56401938
65CHEK20.56068050
66CSNK1E0.54576549
67PRKDC0.54228701
68MTOR0.52946480
69DAPK30.52355307
70PRKAA20.50054926
71PRKCE0.49794339
72STK38L0.48339076
73AKT10.48308012
74GRK10.47874773
75PKN10.45682769
76CSNK2A20.45043806
77ERBB40.44071179
78MAP3K40.43751390
79RPS6KA50.42729642
80MET0.40726509
81PRKACA0.40500711
82RPS6KA10.39429314
83PAK10.37719026
84TNIK0.37704408
85SGK10.36640039
86CDK30.36307089
87FLT30.34933121
88VRK20.34726441
89CSNK2A10.34165184
90ADRBK10.33892272
91GSK3A0.33160752
92MAPK130.32541824
93PRKCA0.31907735
94TEC0.31498680
95CAMK2B0.30633217
96EPHA30.30617695
97PRKCD0.30389308
98MAPK80.30161155
99INSRR0.29748696
100STK30.29283190

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.54017804
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.16710276
3Oxidative phosphorylation_Homo sapiens_hsa001902.88682808
4Protein export_Homo sapiens_hsa030602.74242281
5Tyrosine metabolism_Homo sapiens_hsa003502.47262500
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.31830467
7Parkinsons disease_Homo sapiens_hsa050122.22476931
8Butanoate metabolism_Homo sapiens_hsa006502.11592484
9Fanconi anemia pathway_Homo sapiens_hsa034602.03934356
10Arachidonic acid metabolism_Homo sapiens_hsa005902.02829907
11Regulation of autophagy_Homo sapiens_hsa041402.01933839
12Linoleic acid metabolism_Homo sapiens_hsa005911.88627859
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.87720166
14Huntingtons disease_Homo sapiens_hsa050161.81403306
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.72684833
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.64715340
17Fat digestion and absorption_Homo sapiens_hsa049751.60465733
18Alzheimers disease_Homo sapiens_hsa050101.53283476
19Notch signaling pathway_Homo sapiens_hsa043301.44554820
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.43483952
21Basal cell carcinoma_Homo sapiens_hsa052171.35450413
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.29129780
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27124651
24Cardiac muscle contraction_Homo sapiens_hsa042601.24095397
25Nitrogen metabolism_Homo sapiens_hsa009101.23820703
26Ether lipid metabolism_Homo sapiens_hsa005651.22952168
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.18682596
28Propanoate metabolism_Homo sapiens_hsa006401.16048892
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.15358355
30Homologous recombination_Homo sapiens_hsa034401.08883157
31Steroid biosynthesis_Homo sapiens_hsa001001.06625244
32mRNA surveillance pathway_Homo sapiens_hsa030151.02211558
33Other glycan degradation_Homo sapiens_hsa005111.01146914
34Arginine and proline metabolism_Homo sapiens_hsa003301.00113664
35Hedgehog signaling pathway_Homo sapiens_hsa043400.98081774
36Fatty acid degradation_Homo sapiens_hsa000710.94000469
37Peroxisome_Homo sapiens_hsa041460.92258964
38Chemical carcinogenesis_Homo sapiens_hsa052040.92133638
39Choline metabolism in cancer_Homo sapiens_hsa052310.87657570
40Fatty acid metabolism_Homo sapiens_hsa012120.84960308
41Phototransduction_Homo sapiens_hsa047440.83776359
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82830006
43Non-homologous end-joining_Homo sapiens_hsa034500.81684151
44Steroid hormone biosynthesis_Homo sapiens_hsa001400.79681750
45RNA polymerase_Homo sapiens_hsa030200.79037880
46Sulfur relay system_Homo sapiens_hsa041220.76999320
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76399289
48Glucagon signaling pathway_Homo sapiens_hsa049220.71663089
49Retinol metabolism_Homo sapiens_hsa008300.68957734
50DNA replication_Homo sapiens_hsa030300.62410371
51Fatty acid biosynthesis_Homo sapiens_hsa000610.60358096
52Hippo signaling pathway_Homo sapiens_hsa043900.59134406
53Olfactory transduction_Homo sapiens_hsa047400.58380515
54Nicotine addiction_Homo sapiens_hsa050330.56497734
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55771655
56Wnt signaling pathway_Homo sapiens_hsa043100.55622647
57Glycerophospholipid metabolism_Homo sapiens_hsa005640.55451946
58Axon guidance_Homo sapiens_hsa043600.49347526
59ABC transporters_Homo sapiens_hsa020100.49320956
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49150221
61Metabolic pathways_Homo sapiens_hsa011000.49093052
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46299070
63Tryptophan metabolism_Homo sapiens_hsa003800.44933555
64Vitamin digestion and absorption_Homo sapiens_hsa049770.44150942
65Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.43819171
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.43603181
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42591009
68beta-Alanine metabolism_Homo sapiens_hsa004100.42070949
69Fatty acid elongation_Homo sapiens_hsa000620.40287381
70Insulin secretion_Homo sapiens_hsa049110.39983080
71Primary immunodeficiency_Homo sapiens_hsa053400.39976195
72Nucleotide excision repair_Homo sapiens_hsa034200.38896730
73Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38811388
74Melanogenesis_Homo sapiens_hsa049160.38407285
75Spliceosome_Homo sapiens_hsa030400.37960636
76Inositol phosphate metabolism_Homo sapiens_hsa005620.35504657
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35443204
78Glutathione metabolism_Homo sapiens_hsa004800.35058840
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.31743040
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30945421
81Sulfur metabolism_Homo sapiens_hsa009200.30164322
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.27565879
83ECM-receptor interaction_Homo sapiens_hsa045120.26816869
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.25700796
85Starch and sucrose metabolism_Homo sapiens_hsa005000.25566459
86Glycerolipid metabolism_Homo sapiens_hsa005610.25051214
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.24978499
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.24300521
89AMPK signaling pathway_Homo sapiens_hsa041520.23675754
90Insulin resistance_Homo sapiens_hsa049310.23014950
91Oxytocin signaling pathway_Homo sapiens_hsa049210.22991492
92Ovarian steroidogenesis_Homo sapiens_hsa049130.22703641
93Purine metabolism_Homo sapiens_hsa002300.22674575
94Sphingolipid metabolism_Homo sapiens_hsa006000.20838147
95Thyroid hormone synthesis_Homo sapiens_hsa049180.20720525
96Histidine metabolism_Homo sapiens_hsa003400.20096669
97Amphetamine addiction_Homo sapiens_hsa050310.19741968
98Synaptic vesicle cycle_Homo sapiens_hsa047210.19447358
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.17937676
100Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.17360772

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