KRTAP5-1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1molting cycle (GO:0042303)7.79728804
2hair cycle (GO:0042633)7.79728804
3desmosome organization (GO:0002934)4.78044161
4proline metabolic process (GO:0006560)4.34851292
5negative regulation of fatty acid transport (GO:2000192)4.33309486
6lung epithelium development (GO:0060428)4.28720614
7regulation of cholesterol homeostasis (GO:2000188)4.28278651
8Golgi transport vesicle coating (GO:0048200)4.24619479
9COPI coating of Golgi vesicle (GO:0048205)4.24619479
10semaphorin-plexin signaling pathway (GO:0071526)4.08177570
11intermediate filament organization (GO:0045109)3.83619027
12negative regulation of cell size (GO:0045792)3.76533533
13regulation of ARF GTPase activity (GO:0032312)3.76067152
14G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.75514231
15cell-cell junction maintenance (GO:0045217)3.75039137
16stress granule assembly (GO:0034063)3.70596736
17regulation of cholesterol biosynthetic process (GO:0045540)3.61610698
18negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.60415718
19proline biosynthetic process (GO:0006561)3.58316023
20insulin-like growth factor receptor signaling pathway (GO:0048009)3.56336122
21retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.52370501
22regulation of bile acid biosynthetic process (GO:0070857)3.47695769
23positive regulation of synapse maturation (GO:0090129)3.40122528
24maternal placenta development (GO:0001893)3.35539331
25regulation of female receptivity (GO:0045924)3.32842538
26synaptic vesicle docking involved in exocytosis (GO:0016081)3.32186417
27cytoskeletal anchoring at plasma membrane (GO:0007016)3.31055948
28maintenance of gastrointestinal epithelium (GO:0030277)3.30490058
29adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.22134059
30phosphate ion homeostasis (GO:0055062)3.18911202
31trivalent inorganic anion homeostasis (GO:0072506)3.18911202
32regulation of apoptotic cell clearance (GO:2000425)3.06070275
33cell junction maintenance (GO:0034331)3.01893114
34adherens junction assembly (GO:0034333)3.01837970
35regulation of mammary gland epithelial cell proliferation (GO:0033599)2.98405689
36focal adhesion assembly (GO:0048041)2.98218914
37cell-substrate adherens junction assembly (GO:0007045)2.98218914
38negative regulation of sodium ion transport (GO:0010766)2.93995589
39glucose 6-phosphate metabolic process (GO:0051156)2.93074965
40regulation of ARF protein signal transduction (GO:0032012)2.92443654
41linoleic acid metabolic process (GO:0043651)2.91454143
42regulation of water loss via skin (GO:0033561)2.91096835
434-hydroxyproline metabolic process (GO:0019471)2.90828002
44regulation of extracellular matrix disassembly (GO:0010715)2.90794423
45embryonic retina morphogenesis in camera-type eye (GO:0060059)2.88314421
46epithelial structure maintenance (GO:0010669)2.87144979
47cell migration in hindbrain (GO:0021535)2.87044310
48bundle of His cell to Purkinje myocyte communication (GO:0086069)2.85240853
49peptidyl-tyrosine autophosphorylation (GO:0038083)2.84389208
50very-low-density lipoprotein particle assembly (GO:0034379)2.84371264
51regulation of establishment or maintenance of cell polarity (GO:0032878)2.83799611
52cellular response to prostaglandin stimulus (GO:0071379)2.82940153
53regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.81563899
54positive regulation of histone deacetylation (GO:0031065)2.78237831
55plasma lipoprotein particle assembly (GO:0034377)2.75321873
56basement membrane organization (GO:0071711)2.75049458
57female mating behavior (GO:0060180)2.74851628
58layer formation in cerebral cortex (GO:0021819)2.74783633
59cellular response to epidermal growth factor stimulus (GO:0071364)2.73922965
60ear development (GO:0043583)2.71351510
61negative regulation of fibrinolysis (GO:0051918)2.70668013
62branching involved in mammary gland duct morphogenesis (GO:0060444)2.70400103
63positive regulation of protein kinase C signaling (GO:0090037)2.70271278
64positive regulation of keratinocyte differentiation (GO:0045618)2.69407185
65regulation of cholesterol metabolic process (GO:0090181)2.68874625
66regulation of fatty acid beta-oxidation (GO:0031998)2.67053332
67epithelial cell-cell adhesion (GO:0090136)2.66437724
68regulation of synapse maturation (GO:0090128)2.64509075
69histone H3-K9 demethylation (GO:0033169)2.64162270
70G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.61693301
71establishment of skin barrier (GO:0061436)2.61167519
72peptidyl-glutamic acid carboxylation (GO:0017187)2.60264864
73protein carboxylation (GO:0018214)2.60264864
74atrioventricular valve morphogenesis (GO:0003181)2.60239557
75regulation of histone H3-K27 methylation (GO:0061085)2.59889338
76positive regulation of hormone metabolic process (GO:0032352)2.59669658
77regulation of interleukin-13 production (GO:0032656)2.57220803
78regulation of extracellular matrix organization (GO:1903053)2.56687341
79positive regulation of Cdc42 GTPase activity (GO:0043089)2.55676783
80activation of Rac GTPase activity (GO:0032863)2.52634750
81mitochondrion transport along microtubule (GO:0047497)2.50938639
82establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.50938639
83myelin maintenance (GO:0043217)2.50014258
84protein-lipid complex assembly (GO:0065005)2.48868363
85regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.46616114
86phosphatidylinositol 3-kinase signaling (GO:0014065)2.45853157
87alpha-linolenic acid metabolic process (GO:0036109)2.45032763
88multicellular organismal water homeostasis (GO:0050891)2.44089499
89positive regulation of CREB transcription factor activity (GO:0032793)2.43844028
90cellular anion homeostasis (GO:0030002)2.43195231
91intermediate filament cytoskeleton organization (GO:0045104)2.42658723
92apoptotic process involved in morphogenesis (GO:0060561)2.41353849
93planar cell polarity pathway involved in neural tube closure (GO:0090179)2.39754449
94intestinal cholesterol absorption (GO:0030299)2.39654241
95cellular component maintenance (GO:0043954)2.37823717
96negative regulation of catenin import into nucleus (GO:0035414)2.37485185
97osteoblast development (GO:0002076)2.36898176
98receptor catabolic process (GO:0032801)2.36621875
99dendritic spine organization (GO:0097061)2.35377977
100glutamate secretion (GO:0014047)2.35035733

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.48495802
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.12462942
3ESR2_21235772_ChIP-Seq_MCF-7_Human3.17117060
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.13340333
5THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.94108260
6LXR_22292898_ChIP-Seq_THP-1_Human2.85275646
7TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.80193183
8ZNF263_19887448_ChIP-Seq_K562_Human2.62842754
9RACK7_27058665_Chip-Seq_MCF-7_Human2.62025578
10ESR1_21235772_ChIP-Seq_MCF-7_Human2.35930945
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.22702756
12KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.20695290
13KDM2B_26808549_Chip-Seq_SUP-B15_Human2.19106462
14KDM2B_26808549_Chip-Seq_K562_Human2.17361496
15RUNX1_27514584_Chip-Seq_MCF-7_Human2.11280008
16ESR1_15608294_ChIP-ChIP_MCF-7_Human2.10939310
17ZFP281_18757296_ChIP-ChIP_E14_Mouse2.10155594
18ERG_21242973_ChIP-ChIP_JURKAT_Human2.03943509
19TCF7_22412390_ChIP-Seq_EML_Mouse1.97976410
20KDM2B_26808549_Chip-Seq_DND41_Human1.94370626
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.88724803
22ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.88717913
23CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.86796842
24P68_20966046_ChIP-Seq_HELA_Human1.81147341
25PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.80150071
26* ELK3_25401928_ChIP-Seq_HUVEC_Human1.79023585
27SMC4_20622854_ChIP-Seq_HELA_Human1.78866481
28MYC_22102868_ChIP-Seq_BL_Human1.78641229
29EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.78226347
30ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.75339514
31DNAJC2_21179169_ChIP-ChIP_NT2_Human1.74486730
32ESR1_20079471_ChIP-ChIP_T-47D_Human1.72213144
33TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69729402
34CREB1_26743006_Chip-Seq_LNCaP_Human1.68967185
35DROSHA_22980978_ChIP-Seq_HELA_Human1.67151621
36STAT6_21828071_ChIP-Seq_BEAS2B_Human1.65128553
37WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.62633727
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.60094690
39ZFP281_27345836_Chip-Seq_ESCs_Mouse1.55546825
40SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.53567826
41CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.53351593
42TET1_21451524_ChIP-Seq_MESCs_Mouse1.52768360
43VDR_21846776_ChIP-Seq_THP-1_Human1.51616523
44PPARA_22158963_ChIP-Seq_LIVER_Mouse1.51526608
45ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.51311253
46NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.51251827
47* CTCF_27219007_Chip-Seq_Bcells_Human1.51119366
48UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.44583760
49HIF1A_21447827_ChIP-Seq_MCF-7_Human1.40754893
50RXR_22158963_ChIP-Seq_LIVER_Mouse1.39548560
51CDX2_20551321_ChIP-Seq_CACO-2_Human1.35923240
52SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32983112
53KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.31775834
54FOXA2_19822575_ChIP-Seq_HepG2_Human1.31229632
55CTCF_27219007_Chip-Seq_ERYTHROID_Human1.29378792
56SA1_27219007_Chip-Seq_ERYTHROID_Human1.27056152
57RARB_27405468_Chip-Seq_BRAIN_Mouse1.26263077
58ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23448358
59KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22159958
60P63_26484246_Chip-Seq_KERATINOCYTES_Human1.19625226
61BCOR_27268052_Chip-Seq_Bcells_Human1.18772232
62KDM2B_26808549_Chip-Seq_JURKAT_Human1.17321771
63KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16874013
64TP63_22573176_ChIP-Seq_HFKS_Human1.15191667
65SOX2_27498859_Chip-Seq_STOMACH_Mouse1.14824971
66NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.14682244
67STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.14508492
68FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.11152386
69RARB_24833708_ChIP-Seq_LIVER_Mouse1.08783912
70ATF3_27146783_Chip-Seq_COLON_Human1.08464358
71SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.08386664
72MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.08330625
73SUZ12_27294783_Chip-Seq_ESCs_Mouse1.05803458
74TP53_22127205_ChIP-Seq_IMR90_Human1.05146436
75ELF1_20517297_ChIP-Seq_JURKAT_Human1.05133415
76* EZH2_27294783_Chip-Seq_ESCs_Mouse1.04599924
77* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04171739
78RARA_24833708_ChIP-Seq_LIVER_Mouse1.04056244
79KLF5_25053715_ChIP-Seq_YYC3_Human1.04000451
80* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03972104
81KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03374752
82PKCTHETA_26484144_Chip-Seq_BREAST_Human1.02827769
83PHF8_20622854_ChIP-Seq_HELA_Human1.02733894
84E2F1_20622854_ChIP-Seq_HELA_Human1.01179252
85GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99925179
86SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.98984150
87OCT4_19829295_ChIP-Seq_ESCs_Human0.98018155
88CLOCK_20551151_ChIP-Seq_293T_Human0.97114688
89CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.97073988
90TET1_21490601_ChIP-Seq_MESCs_Mouse0.96121443
91* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.95406565
92BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.94070752
93GATA6_25053715_ChIP-Seq_YYC3_Human0.93617665
94RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93439865
95E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.92804988
96SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.92681133
97POU5F1_16518401_ChIP-PET_MESCs_Mouse0.92371511
98GATA1_19941827_ChIP-Seq_MEL_Mouse0.90517145
99DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90261225
100CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90239612

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002098_abnormal_vibrissa_morphology3.76406662
2MP0005451_abnormal_body_composition3.60021471
3MP0005409_darkened_coat_color3.44746500
4MP0003705_abnormal_hypodermis_morpholog3.37179881
5MP0002796_impaired_skin_barrier3.33350782
6MP0003123_paternal_imprinting3.15416024
7MP0004381_abnormal_hair_follicle3.14105458
8MP0000566_synostosis3.08097292
9MP0000579_abnormal_nail_morphology3.08092706
10MP0010234_abnormal_vibrissa_follicle2.97175020
11MP0005058_abnormal_lysosome_morphology2.51364342
12MP0002249_abnormal_larynx_morphology2.51188442
13MP0003122_maternal_imprinting2.40601535
14MP0005076_abnormal_cell_differentiation2.26829962
15MP0003172_abnormal_lysosome_physiology2.24500887
16MP0004264_abnormal_extraembryonic_tissu2.23184515
17MP0003183_abnormal_peptide_metabolism2.12643620
18MP0000678_abnormal_parathyroid_gland2.08040270
19MP0009780_abnormal_chondrocyte_physiolo2.01034803
20MP0004858_abnormal_nervous_system1.96091916
21MP0002822_catalepsy1.95012802
22MP0000377_abnormal_hair_follicle1.86143207
23MP0004859_abnormal_synaptic_plasticity1.84652494
24MP0003453_abnormal_keratinocyte_physiol1.84527801
25MP0005501_abnormal_skin_physiology1.83783416
26MP0002089_abnormal_postnatal_growth/wei1.82178598
27MP0004185_abnormal_adipocyte_glucose1.80766061
28MP0000647_abnormal_sebaceous_gland1.73517066
29MP0000462_abnormal_digestive_system1.73299359
30MP0003878_abnormal_ear_physiology1.70709340
31MP0005377_hearing/vestibular/ear_phenot1.70709340
32MP0001849_ear_inflammation1.62419609
33MP0004270_analgesia1.54317611
34MP0003115_abnormal_respiratory_system1.40999980
35MP0005365_abnormal_bile_salt1.35778976
36MP0005275_abnormal_skin_tensile1.35211432
37MP0002060_abnormal_skin_morphology1.35157845
38MP0000003_abnormal_adipose_tissue1.33577186
39MP0001666_abnormal_nutrient_absorption1.32174062
40MP0004947_skin_inflammation1.30284738
41MP0005360_urolithiasis1.30227014
42MP0000537_abnormal_urethra_morphology1.29481388
43MP0009384_cardiac_valve_regurgitation1.28701856
44MP0000751_myopathy1.28586537
45MP0008260_abnormal_autophagy1.24609600
46MP0000747_muscle_weakness1.23372179
47MP0005666_abnormal_adipose_tissue1.21569291
48MP0000383_abnormal_hair_follicle1.20175541
49MP0003879_abnormal_hair_cell1.19715094
50MP0009278_abnormal_bone_marrow1.17342864
51MP0005375_adipose_tissue_phenotype1.16630854
52MP0001348_abnormal_lacrimal_gland1.15942284
53MP0001188_hyperpigmentation1.13077028
54MP0009672_abnormal_birth_weight1.11954651
55MP0002184_abnormal_innervation1.11916173
56MP0000467_abnormal_esophagus_morphology1.11401763
57MP0005083_abnormal_biliary_tract1.09754710
58MP0005423_abnormal_somatic_nervous1.07093770
59MP0008872_abnormal_physiological_respon1.06376125
60MP0005670_abnormal_white_adipose1.06124652
61MP0000013_abnormal_adipose_tissue1.05682499
62MP0005257_abnormal_intraocular_pressure1.05679466
63MP0003121_genomic_imprinting1.04596315
64MP0000367_abnormal_coat/_hair1.04542376
65MP0010678_abnormal_skin_adnexa1.03367907
66MP0010630_abnormal_cardiac_muscle1.02888732
67MP0010771_integument_phenotype1.02407374
68MP0001216_abnormal_epidermal_layer1.01997901
69MP0002909_abnormal_adrenal_gland0.99846685
70MP0002970_abnormal_white_adipose0.98536636
71MP0008875_abnormal_xenobiotic_pharmacok0.97311103
72MP0003942_abnormal_urinary_system0.95884787
73MP0009931_abnormal_skin_appearance0.94099435
74MP0000538_abnormal_urinary_bladder0.85049132
75MP0001765_abnormal_ion_homeostasis0.83659844
76MP0004782_abnormal_surfactant_physiolog0.81640704
77MP0003566_abnormal_cell_adhesion0.79044639
78MP0002127_abnormal_cardiovascular_syste0.78243428
79MP0000534_abnormal_ureter_morphology0.78193845
80MP0006138_congestive_heart_failure0.77092792
81MP0010329_abnormal_lipoprotein_level0.76750776
82MP0003329_amyloid_beta_deposits0.75501031
83MP0003635_abnormal_synaptic_transmissio0.72769993
84MP0003938_abnormal_ear_development0.71277511
85MP0003787_abnormal_imprinting0.71203091
86MP0005330_cardiomyopathy0.71064055
87MP0002932_abnormal_joint_morphology0.68723654
88MP0003634_abnormal_glial_cell0.67920199
89MP0002876_abnormal_thyroid_physiology0.66555353
90MP0002396_abnormal_hematopoietic_system0.62739642
91MP0001340_abnormal_eyelid_morphology0.62341796
92MP0002139_abnormal_hepatobiliary_system0.59013998
93MP0002063_abnormal_learning/memory/cond0.56946602
94MP0004087_abnormal_muscle_fiber0.56826982
95MP0002116_abnormal_craniofacial_bone0.56735102
96MP0002108_abnormal_muscle_morphology0.55927037
97MP0004084_abnormal_cardiac_muscle0.55601270
98MP0000955_abnormal_spinal_cord0.54045326
99MP0000477_abnormal_intestine_morphology0.53260727
100MP0008569_lethality_at_weaning0.52360011

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.35140603
2Pili torti (HP:0003777)4.93904649
3Broad face (HP:0000283)4.53650911
4Thin bony cortex (HP:0002753)3.94928090
5Hyperacusis (HP:0010780)3.58097132
6Woolly hair (HP:0002224)3.51483027
7Cerebral aneurysm (HP:0004944)3.46005322
8J-shaped sella turcica (HP:0002680)3.36301054
9Abnormal hair laboratory examination (HP:0003328)3.35928426
10Asymmetry of the thorax (HP:0001555)3.29954009
11Ependymoma (HP:0002888)3.25928011
12Obstructive sleep apnea (HP:0002870)3.07477290
13Hypotrichosis (HP:0001006)3.04470345
14Slow-growing hair (HP:0002217)3.01014465
15Abnormality of hair growth rate (HP:0011363)3.01014465
16Brittle hair (HP:0002299)3.00569138
17Lymphangioma (HP:0100764)2.72336422
18Septate vagina (HP:0001153)2.63109839
19Flat acetabular roof (HP:0003180)2.60224462
20Right ventricular cardiomyopathy (HP:0011663)2.56294971
21Hemorrhage of the eye (HP:0011885)2.51617125
22Macroorchidism (HP:0000053)2.36411675
23Onycholysis (HP:0001806)2.35823789
24Prolonged partial thromboplastin time (HP:0003645)2.35710190
25Bronchomalacia (HP:0002780)2.33870258
26Abnormality of the astrocytes (HP:0100707)2.30777323
27Astrocytoma (HP:0009592)2.30777323
28Widely patent fontanelles and sutures (HP:0004492)2.20678966
29Ankle clonus (HP:0011448)2.13219170
30Neonatal death (HP:0003811)2.08208636
31Heterotopia (HP:0002282)2.06850907
32Hypercholesterolemia (HP:0003124)2.05789930
33Nuclear cataract (HP:0100018)2.02774635
34Sparse lateral eyebrow (HP:0005338)1.97888783
35Cervical subluxation (HP:0003308)1.95398601
36Renal duplication (HP:0000075)1.94878790
37Abnormality of the fingertips (HP:0001211)1.94561018
38Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.93414572
39Overriding aorta (HP:0002623)1.92602313
40Absent eyelashes (HP:0000561)1.91231265
41Advanced eruption of teeth (HP:0006288)1.91097078
42Mitral regurgitation (HP:0001653)1.90500196
43Biconcave vertebral bodies (HP:0004586)1.90178405
44Joint hemorrhage (HP:0005261)1.88287393
45Abnormality of the gastric mucosa (HP:0004295)1.87949660
46Dysostosis multiplex (HP:0000943)1.87727022
47Broad palm (HP:0001169)1.87055652
48Germ cell neoplasia (HP:0100728)1.85306003
49Axonal loss (HP:0003447)1.84878560
50Visceral angiomatosis (HP:0100761)1.83399142
51Upper limb amyotrophy (HP:0009129)1.83167627
52Distal upper limb amyotrophy (HP:0007149)1.83167627
53Limited elbow extension (HP:0001377)1.82357535
54Abnormal vertebral ossification (HP:0100569)1.81812364
55Neoplasm of the heart (HP:0100544)1.79487301
56Akinesia (HP:0002304)1.79245762
57Amelogenesis imperfecta (HP:0000705)1.76855645
58Broad alveolar ridges (HP:0000187)1.76592491
59Renovascular hypertension (HP:0100817)1.76496968
60Micronodular cirrhosis (HP:0001413)1.76450969
61Nail dystrophy (HP:0008404)1.75597173
62Metaphyseal cupping (HP:0003021)1.74700145
63Delayed epiphyseal ossification (HP:0002663)1.74152493
64Elfin facies (HP:0004428)1.74141785
65Esophageal varix (HP:0002040)1.73908052
66Menorrhagia (HP:0000132)1.73874508
67Abnormality of the thoracic spine (HP:0100711)1.73161088
68Abnormality of nail color (HP:0100643)1.72181416
69Hypoplastic ischia (HP:0003175)1.72113727
70Insomnia (HP:0100785)1.71378702
71Hyperparathyroidism (HP:0000843)1.70173103
72Wide cranial sutures (HP:0010537)1.69778727
73Absent eyebrow (HP:0002223)1.69191392
74Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.67019333
75Craniofacial hyperostosis (HP:0004493)1.65484987
76Neurodegeneration (HP:0002180)1.65106855
77Hypoplasia of the capital femoral epiphysis (HP:0003090)1.65071464
78Increased IgE level (HP:0003212)1.64838451
79Foot dorsiflexor weakness (HP:0009027)1.64408434
80Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.63929264
81Turricephaly (HP:0000262)1.63769264
82Small epiphyses (HP:0010585)1.62363290
83Hypoplasia of the thymus (HP:0000778)1.61899068
84Protrusio acetabuli (HP:0003179)1.61305517
85Ulnar bowing (HP:0003031)1.60296851
86Bowel diverticulosis (HP:0005222)1.60252748
87Urinary glycosaminoglycan excretion (HP:0003541)1.57400232
88Mucopolysacchariduria (HP:0008155)1.57400232
89Hemangiomatosis (HP:0007461)1.57200943
90Deformed sella turcica (HP:0002681)1.56919924
91Aneurysm (HP:0002617)1.56676759
92Abnormality of the frontal sinuses (HP:0002687)1.55778625
93Onion bulb formation (HP:0003383)1.54913989
94Abnormality of the ischium (HP:0003174)1.53976606
95Neonatal short-limb short stature (HP:0008921)1.53479820
96EMG: neuropathic changes (HP:0003445)1.52193833
97Hypercortisolism (HP:0001578)1.51638920
98Easy fatigability (HP:0003388)1.51331789
99Abnormality of lateral ventricle (HP:0030047)1.51181015
100Abdominal distention (HP:0003270)1.50392592

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.42721565
2SIK14.63556651
3FGFR43.57086911
4EEF2K2.99699421
5PKN22.86221666
6CDK122.70852659
7RIPK12.65838112
8EPHA22.53152857
9ICK2.45989036
10MST1R2.42863868
11MAPKAPK32.42804247
12WNK42.32527611
13SMG12.12707050
14SIK21.87302626
15SCYL21.75389057
16NME11.67056447
17PRKD31.58438300
18RPS6KB21.56297462
19ERN11.51532426
20LMTK21.50237761
21FGFR31.47238714
22TYRO31.34371214
23NTRK31.25824168
24MARK21.18178633
25PDGFRA1.18067856
26TNK21.13882405
27MUSK1.11939918
28MTOR1.06933392
29PTK21.06352063
30RPS6KA21.05387409
31PTK61.04962521
32ERBB21.04913613
33FGFR21.03872783
34PIK3CA1.02392846
35PRKCI1.01043246
36RET1.00918342
37PDPK10.97389553
38CAMKK10.95302020
39IRAK30.93430749
40AKT30.92004553
41MAP2K60.89268049
42WNK10.86188440
43TESK20.84049093
44MAP2K20.82694211
45TAOK10.82185655
46GRK60.81939945
47MAP3K100.76947402
48MET0.75473093
49SIK30.75207483
50STK390.75180527
51MATK0.74261011
52PRKD20.74068669
53MAP3K60.72813035
54NTRK20.72291393
55TESK10.72127559
56CDK70.72099646
57DYRK1B0.64396661
58CDC42BPA0.64055398
59FGFR10.63858569
60MAP3K70.63505838
61RPS6KC10.61864107
62RPS6KL10.61864107
63PAK40.60289130
64PRPF4B0.55640211
65PDK10.55624586
66DAPK10.55550611
67MARK10.53986509
68MAPK80.53517928
69NTRK10.53474147
70CHUK0.50673997
71MAPK110.48327255
72LATS20.46691624
73CAMK1D0.45898282
74CDK30.44722912
75MAPK100.44324584
76TTN0.44023167
77NEK60.43983175
78PRKCH0.42881208
79RPS6KA60.42343173
80BRD40.41243585
81PRKAA10.40774002
82ILK0.40406289
83HIPK20.40329747
84EPHA40.39559465
85CDK150.39298722
86MAPK150.39121447
87MAPK120.37941420
88CDK11A0.35243842
89CDK180.34851425
90ITK0.34550415
91PRKG20.34458083
92PRKD10.34037311
93RPS6KB10.33411968
94MAPKAPK50.33379472
95MAP3K20.31930613
96CDK50.31858466
97MAPKAPK20.30987037
98CDK90.30655982
99GSK3B0.30129988
100PHKG20.29807620

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.02287719
2Cyanoamino acid metabolism_Homo sapiens_hsa004602.22439444
3Fatty acid biosynthesis_Homo sapiens_hsa000612.06700811
4Glycosaminoglycan degradation_Homo sapiens_hsa005311.87267450
5Lysine degradation_Homo sapiens_hsa003101.86276033
6Notch signaling pathway_Homo sapiens_hsa043301.83345514
7ABC transporters_Homo sapiens_hsa020101.78536054
8VEGF signaling pathway_Homo sapiens_hsa043701.66674439
9Phenylalanine metabolism_Homo sapiens_hsa003601.62411886
10mTOR signaling pathway_Homo sapiens_hsa041501.55920914
11AMPK signaling pathway_Homo sapiens_hsa041521.50067239
12Insulin signaling pathway_Homo sapiens_hsa049101.50011131
13Central carbon metabolism in cancer_Homo sapiens_hsa052301.47950796
14Endometrial cancer_Homo sapiens_hsa052131.44011443
15Non-small cell lung cancer_Homo sapiens_hsa052231.41390275
16Estrogen signaling pathway_Homo sapiens_hsa049151.38677135
17Phosphatidylinositol signaling system_Homo sapiens_hsa040701.38237128
18ErbB signaling pathway_Homo sapiens_hsa040121.34833055
19Choline metabolism in cancer_Homo sapiens_hsa052311.33081757
20Longevity regulating pathway - mammal_Homo sapiens_hsa042111.32730135
21Thyroid hormone signaling pathway_Homo sapiens_hsa049191.32109252
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.30864735
23GnRH signaling pathway_Homo sapiens_hsa049121.28546452
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.27782705
25Cocaine addiction_Homo sapiens_hsa050301.26361937
26Long-term potentiation_Homo sapiens_hsa047201.25250290
27Fructose and mannose metabolism_Homo sapiens_hsa000511.24581354
28Amphetamine addiction_Homo sapiens_hsa050311.24331017
29Glucagon signaling pathway_Homo sapiens_hsa049221.23359574
30Complement and coagulation cascades_Homo sapiens_hsa046101.19237128
31Histidine metabolism_Homo sapiens_hsa003401.17653054
32Glioma_Homo sapiens_hsa052141.17201572
33Arginine biosynthesis_Homo sapiens_hsa002201.16685834
34Bile secretion_Homo sapiens_hsa049761.15289061
35Vitamin digestion and absorption_Homo sapiens_hsa049771.14837918
36Insulin resistance_Homo sapiens_hsa049311.10937545
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10756108
38Axon guidance_Homo sapiens_hsa043601.08650513
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.08525181
40Acute myeloid leukemia_Homo sapiens_hsa052211.07149981
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.05255886
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.04617109
43Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.03704623
44Phospholipase D signaling pathway_Homo sapiens_hsa040721.02736531
45PPAR signaling pathway_Homo sapiens_hsa033201.01405220
46Neurotrophin signaling pathway_Homo sapiens_hsa047221.01072038
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.00526391
48Chronic myeloid leukemia_Homo sapiens_hsa052200.98525804
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.94920402
50Vitamin B6 metabolism_Homo sapiens_hsa007500.93198295
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.92079203
52Bladder cancer_Homo sapiens_hsa052190.89731611
53Inositol phosphate metabolism_Homo sapiens_hsa005620.88363426
54Fatty acid metabolism_Homo sapiens_hsa012120.86609412
55Tight junction_Homo sapiens_hsa045300.86292216
56Thyroid hormone synthesis_Homo sapiens_hsa049180.83521821
57Glycerophospholipid metabolism_Homo sapiens_hsa005640.83482970
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83476601
59Dopaminergic synapse_Homo sapiens_hsa047280.81473192
60Steroid biosynthesis_Homo sapiens_hsa001000.78703270
61Arginine and proline metabolism_Homo sapiens_hsa003300.77468745
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.75722721
63Renin secretion_Homo sapiens_hsa049240.75552132
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74856859
65Adipocytokine signaling pathway_Homo sapiens_hsa049200.74493988
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74065729
67cAMP signaling pathway_Homo sapiens_hsa040240.72710405
68Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.71964379
69Renal cell carcinoma_Homo sapiens_hsa052110.70328884
70Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.69604177
71Endocytosis_Homo sapiens_hsa041440.67821734
72Synaptic vesicle cycle_Homo sapiens_hsa047210.67195218
73Galactose metabolism_Homo sapiens_hsa000520.65045000
74Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64713837
75Focal adhesion_Homo sapiens_hsa045100.64161871
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62740335
77Tyrosine metabolism_Homo sapiens_hsa003500.61923759
78ECM-receptor interaction_Homo sapiens_hsa045120.61828654
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.61466712
80HIF-1 signaling pathway_Homo sapiens_hsa040660.60422767
81Prion diseases_Homo sapiens_hsa050200.60255066
82Pancreatic cancer_Homo sapiens_hsa052120.59204520
83Fat digestion and absorption_Homo sapiens_hsa049750.58520785
84Glutamatergic synapse_Homo sapiens_hsa047240.56168581
85Ovarian steroidogenesis_Homo sapiens_hsa049130.56129406
86Hepatitis C_Homo sapiens_hsa051600.56084683
87Gastric acid secretion_Homo sapiens_hsa049710.55561624
88Cholinergic synapse_Homo sapiens_hsa047250.55453794
89Sulfur relay system_Homo sapiens_hsa041220.54578199
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54530653
91Melanogenesis_Homo sapiens_hsa049160.53486733
92N-Glycan biosynthesis_Homo sapiens_hsa005100.51734997
93Circadian entrainment_Homo sapiens_hsa047130.50821410
94Oxytocin signaling pathway_Homo sapiens_hsa049210.50624744
95Prolactin signaling pathway_Homo sapiens_hsa049170.50276843
96Proteoglycans in cancer_Homo sapiens_hsa052050.49828797
97Insulin secretion_Homo sapiens_hsa049110.49330180
98Salivary secretion_Homo sapiens_hsa049700.49200329
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49026923
100Dilated cardiomyopathy_Homo sapiens_hsa054140.48961560

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