KRTAP4-9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1citrulline biosynthetic process (GO:0019240)9.83694800
2adhesion of symbiont to host (GO:0044406)9.45961254
3hair follicle morphogenesis (GO:0031069)8.68003708
4peptide cross-linking (GO:0018149)8.63383263
5intermediate filament cytoskeleton organization (GO:0045104)6.89515494
6intermediate filament-based process (GO:0045103)6.67584554
7citrulline metabolic process (GO:0000052)6.52499570
8cell wall macromolecule metabolic process (GO:0044036)6.42574914
9cell wall macromolecule catabolic process (GO:0016998)6.42574914
10epidermis development (GO:0008544)6.09655687
11keratinocyte differentiation (GO:0030216)5.84554619
12hair cycle process (GO:0022405)5.58572235
13molting cycle process (GO:0022404)5.58572235
14bundle of His cell to Purkinje myocyte communication (GO:0086069)5.57421519
15peptidyl-arginine modification (GO:0018195)5.44304668
16skin morphogenesis (GO:0043589)5.19125348
17establishment of skin barrier (GO:0061436)5.04361712
18hemidesmosome assembly (GO:0031581)4.84685303
19epidermal cell differentiation (GO:0009913)4.56435114
20regulation of water loss via skin (GO:0033561)4.50839574
21tooth mineralization (GO:0034505)4.06330675
22* molting cycle (GO:0042303)33.2316135
23* hair cycle (GO:0042633)33.2316135
24keratinocyte development (GO:0003334)3.86331082
25negative regulation of establishment of protein localization to plasma membrane (GO:0090005)3.56986250
26negative regulation of keratinocyte proliferation (GO:0010839)3.48530102
27hair follicle development (GO:0001942)3.29212893
28phosphatidylinositol acyl-chain remodeling (GO:0036149)3.25238991
29positive regulation of hair follicle development (GO:0051798)3.20262459
30positive regulation of hair cycle (GO:0042635)3.20262459
31regulation of keratinocyte differentiation (GO:0045616)3.15630244
32multicellular organismal water homeostasis (GO:0050891)3.06923416
33regulation of hair follicle development (GO:0051797)3.03957914
34phosphatidylserine acyl-chain remodeling (GO:0036150)2.97703386
35negative regulation of protein localization to plasma membrane (GO:1903077)2.95099148
36atrioventricular valve morphogenesis (GO:0003181)2.94334938
37epithelium development (GO:0060429)2.90266111
38gap junction assembly (GO:0016264)2.89548143
39ectoderm development (GO:0007398)2.84865307
40bone trabecula formation (GO:0060346)2.77705026
41positive regulation of epidermis development (GO:0045684)2.75755513
42fatty acid elongation (GO:0030497)2.71698004
43phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.71691559
44regulation of hair cycle (GO:0042634)2.68433892
45positive regulation of meiotic cell cycle (GO:0051446)2.66559754
46ventricular cardiac muscle cell action potential (GO:0086005)2.60920502
47lymph vessel development (GO:0001945)2.58156114
48water homeostasis (GO:0030104)2.51059430
49negative regulation of cell fate specification (GO:0009996)2.49757235
50regulation of epidermal cell differentiation (GO:0045604)2.48318680
51epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.47396292
52regulation of epidermis development (GO:0045682)2.43369284
53regulation of mesenchymal cell apoptotic process (GO:2001053)2.35383592
54phosphatidylserine metabolic process (GO:0006658)2.29040218
55positive regulation of epidermal cell differentiation (GO:0045606)2.27838628
56cell surface receptor signaling pathway involved in heart development (GO:0061311)2.27659281
57cytoskeletal anchoring at plasma membrane (GO:0007016)2.24547210
58regulation of cardioblast differentiation (GO:0051890)2.21247051
59regulation of heart rate by cardiac conduction (GO:0086091)2.19325156
60skin development (GO:0043588)2.18681252
61wound healing, spreading of epidermal cells (GO:0035313)2.16925081
62epithelial cell-cell adhesion (GO:0090136)2.16130851
63phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.15586442
64myotube differentiation (GO:0014902)2.14619282
65regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.11457719
66cranial suture morphogenesis (GO:0060363)2.08529156
67cell communication involved in cardiac conduction (GO:0086065)2.08000148
68outflow tract septum morphogenesis (GO:0003148)2.07107319
69positive regulation of monocyte chemotaxis (GO:0090026)2.03314654
70planar cell polarity pathway involved in neural tube closure (GO:0090179)2.00434921
71intermediate filament organization (GO:0045109)12.7011913
72adhesion of symbiont to host cell (GO:0044650)11.1814799
73virion attachment to host cell (GO:0019062)11.1814799
74keratinization (GO:0031424)10.9105244
75desmosome organization (GO:0002934)10.5606675
76coronary vasculature morphogenesis (GO:0060977)1.99690048
77negative regulation of epidermis development (GO:0045683)1.94605788
78regulation of keratinocyte proliferation (GO:0010837)1.93505478
79regulation of secondary heart field cardioblast proliferation (GO:0003266)1.91212500
80regulation of cardioblast proliferation (GO:0003264)1.91212500
81regulation of ruffle assembly (GO:1900027)1.90526181
82phosphatidylcholine acyl-chain remodeling (GO:0036151)1.90261112
83ephrin receptor signaling pathway (GO:0048013)1.88117050
84antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)1.87623455
85antigen processing and presentation of endogenous peptide antigen (GO:0002483)1.87623455
86regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)1.85758562
87non-canonical Wnt signaling pathway (GO:0035567)1.83399267
88cell-substrate junction assembly (GO:0007044)1.82665027
89* aging (GO:0007568)1.77505400
90outer ear morphogenesis (GO:0042473)1.76101991
91cardiac conduction (GO:0061337)1.72683781
92negative regulation of cell fate commitment (GO:0010454)1.72428310
93cellular modified amino acid biosynthetic process (GO:0042398)1.69645827
94very long-chain fatty acid metabolic process (GO:0000038)1.68945983
95establishment of planar polarity (GO:0001736)1.68848344
96establishment of tissue polarity (GO:0007164)1.68848344
97alditol phosphate metabolic process (GO:0052646)1.68721626
98G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071991.68709482
99regulation of transforming growth factor beta2 production (GO:0032909)1.68520845
100cardiac muscle cell action potential involved in contraction (GO:0086002)1.67500285

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.50013809
2CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.78070465
3P63_26484246_Chip-Seq_KERATINOCYTES_Human3.43833811
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.66195960
5BMI1_19503595_ChIP-Seq_MEFsC_Mouse2.18680821
6* CTCF_20526341_ChIP-Seq_ESCs_Human2.10523161
7* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse2.09989958
8PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.04056409
9TP63_17297297_ChIP-ChIP_HaCaT_Human12.3665942
10E2F1_20622854_ChIP-Seq_HELA_Human1.80481633
11CSB_26484114_Chip-Seq_FIBROBLAST_Human1.71002290
12VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.70932775
13EGR1_19032775_ChIP-ChIP_M12_Human1.70912954
14SOX9_24532713_ChIP-Seq_HFSC_Mouse1.68536102
15P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.67720409
16NANOG_20526341_ChIP-Seq_ESCs_Human1.66020928
17CTCF_27219007_Chip-Seq_Bcells_Human1.61527281
18* TAF2_19829295_ChIP-Seq_ESCs_Human1.59941696
19LXR_22292898_ChIP-Seq_THP-1_Human1.56118570
20TP53_20018659_ChIP-ChIP_R1E_Mouse1.55271395
21RACK7_27058665_Chip-Seq_MCF-7_Human1.52162145
22DNAJC2_21179169_ChIP-ChIP_NT2_Human1.51676668
23FOXO3_23340844_ChIP-Seq_DLD1_Human1.51017087
24P53_21459846_ChIP-Seq_SAOS-2_Human1.49547158
25ERG_20517297_ChIP-Seq_VCAP_Human1.49198112
26TP63_22573176_ChIP-Seq_HFKS_Human1.46942887
27SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.46910411
28SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.46910411
29* MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.41067163
30ESR1_21235772_ChIP-Seq_MCF-7_Human1.40809571
31BCL6_27268052_Chip-Seq_Bcells_Human1.39126913
32UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.38542849
33ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.35587238
34ATF3_27146783_Chip-Seq_COLON_Human1.35507729
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.32755206
36YY1_22570637_ChIP-Seq_MALME-3M_Human1.32212942
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.30436646
38BCOR_27268052_Chip-Seq_Bcells_Human1.29610235
39SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.29575356
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.26503239
41SUZ12_27294783_Chip-Seq_ESCs_Mouse1.25959713
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22721376
43ARNT_22903824_ChIP-Seq_MCF-7_Human1.22667500
44KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22193889
45AHR_22903824_ChIP-Seq_MCF-7_Human1.19327007
46JARID2_20075857_ChIP-Seq_MESCs_Mouse1.16079440
47KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15245280
48SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.14275481
49PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.13424875
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12910013
51SMC4_20622854_ChIP-Seq_HELA_Human1.12497671
52P68_20966046_ChIP-Seq_HELA_Human1.11665670
53TRIM28_21343339_ChIP-Seq_HEK293_Human1.11304639
54E2F1_17053090_ChIP-ChIP_MCF-7_Human1.10956514
55P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10535357
56CEBPB_22108803_ChIP-Seq_LS180_Human1.10521101
57ELF1_20517297_ChIP-Seq_JURKAT_Human1.10059720
58RAC3_21632823_ChIP-Seq_H3396_Human1.09135096
59GATA3_24758297_ChIP-Seq_MCF-7_Human1.07623822
60UBF1/2_26484160_Chip-Seq_HMECs_Human1.06099697
61* PHF8_20622854_ChIP-Seq_HELA_Human1.05484208
62GATA4_25053715_ChIP-Seq_YYC3_Human1.04246695
63ELK4_26923725_Chip-Seq_MESODERM_Mouse1.03937561
64TP63_23658742_ChIP-Seq_EP156T_Human1.02224545
65ERG_21242973_ChIP-ChIP_JURKAT_Human1.02083638
66RXRA_24833708_ChIP-Seq_LIVER_Mouse1.00856064
67SA1_27219007_Chip-Seq_ERYTHROID_Human1.00775804
68KLF5_25053715_ChIP-Seq_YYC3_Human0.99999667
69SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97884315
70SOX2_21211035_ChIP-Seq_LN229_Human0.96044643
71SPI1_20517297_ChIP-Seq_HL60_Human0.96019967
72* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96004734
73RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.94056218
74CDX2_19796622_ChIP-Seq_MESCs_Mouse0.93888488
75CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91938396
76RING1B_27294783_Chip-Seq_ESCs_Mouse0.91579940
77GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.91539969
78EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90407723
79FOXH1_21741376_ChIP-Seq_ESCs_Human0.89957199
80RNF2_27304074_Chip-Seq_ESCs_Mouse0.89136838
81* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89016100
82ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.88598012
83RUNX1_27514584_Chip-Seq_MCF-7_Human0.88171672
84TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88130159
85NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.87874169
86TP53_18474530_ChIP-ChIP_U2OS_Human0.87359701
87RXR_22108803_ChIP-Seq_LS180_Human0.86869846
88EZH2_27294783_Chip-Seq_ESCs_Mouse0.85255177
89SOX2_20726797_ChIP-Seq_SW620_Human0.85144836
90ZFP281_18757296_ChIP-ChIP_E14_Mouse0.83980896
91TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.82461952
92AR_21572438_ChIP-Seq_LNCaP_Human0.81944747
93ZNF263_19887448_ChIP-Seq_K562_Human0.81679267
94GATA6_21074721_ChIP-Seq_CACO-2_Human0.81623091
95GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.81221800
96SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.80149091
97VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.79589307
98SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.78059083
99ELK3_25401928_ChIP-Seq_HUVEC_Human0.77711971
100ZNF217_24962896_ChIP-Seq_MCF-7_Human0.77569484

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology7.83412144
2MP0002098_abnormal_vibrissa_morphology7.30998132
3MP0000647_abnormal_sebaceous_gland6.56269727
4MP0002796_impaired_skin_barrier5.72346452
5MP0010234_abnormal_vibrissa_follicle5.13503997
6MP0005275_abnormal_skin_tensile5.04326665
7MP0000383_abnormal_hair_follicle4.52280746
8MP0000377_abnormal_hair_follicle4.12952286
9MP0010678_abnormal_skin_adnexa4.02829058
10MP0003705_abnormal_hypodermis_morpholog3.84066933
11MP0005501_abnormal_skin_physiology3.60154032
12MP0000427_abnormal_hair_cycle3.53642919
13MP0002254_reproductive_system_inflammat2.95086277
14MP0001216_abnormal_epidermal_layer2.59908734
15MP0004381_abnormal_hair_follicle2.47434771
16MP0000367_abnormal_coat/_hair2.35769875
17MP0004947_skin_inflammation2.22906038
18MP0010771_integument_phenotype2.22125801
19MP0001243_abnormal_dermal_layer2.18411531
20MP0003453_abnormal_keratinocyte_physiol2.14407681
21MP0002234_abnormal_pharynx_morphology2.12640626
22MP0002060_abnormal_skin_morphology2.07793410
23MP0000467_abnormal_esophagus_morphology1.73004894
24MP0009053_abnormal_anal_canal1.48519360
25MP0000762_abnormal_tongue_morphology1.47765215
26MP0003566_abnormal_cell_adhesion1.45972333
27MP0009931_abnormal_skin_appearance1.44841258
28MP0005409_darkened_coat_color1.27931805
29MP0003941_abnormal_skin_development1.01765644
30MP0004885_abnormal_endolymph0.99112797
31MP0001191_abnormal_skin_condition0.94619672
32MP0001851_eye_inflammation0.86030663
33MP0004264_abnormal_extraembryonic_tissu0.83649960
34MP0004185_abnormal_adipocyte_glucose0.83512586
35MP0002095_abnormal_skin_pigmentation0.74234058
36MP0001849_ear_inflammation0.68792169
37MP0003315_abnormal_perineum_morphology0.66350974
38MP0001661_extended_life_span0.66106343
39MP0008438_abnormal_cutaneous_collagen0.65560549
40MP0001340_abnormal_eyelid_morphology0.65221118
41MP0001346_abnormal_lacrimal_gland0.64751976
42MP0002877_abnormal_melanocyte_morpholog0.61804726
43MP0000627_abnormal_mammary_gland0.55137606
44MP0010030_abnormal_orbit_morphology0.53210881
45MP0000566_synostosis0.52746176
46MP0002282_abnormal_trachea_morphology0.52487032
47MP0002249_abnormal_larynx_morphology0.51036550
48MP0003755_abnormal_palate_morphology0.50042765
49MP0003191_abnormal_cellular_cholesterol0.49397663
50MP0005023_abnormal_wound_healing0.47788520
51MP0002970_abnormal_white_adipose0.47785382
52MP0000678_abnormal_parathyroid_gland0.47576990
53MP0001784_abnormal_fluid_regulation0.44369647
54MP0005451_abnormal_body_composition0.43852892
55MP0002111_abnormal_tail_morphology0.37998172
56MP0004272_abnormal_basement_membrane0.37799632
57MP0009840_abnormal_foam_cell0.35567598
58MP0005075_abnormal_melanosome_morpholog0.34587024
59MP0003385_abnormal_body_wall0.31372941
60MP0010352_gastrointestinal_tract_polyps0.29690097
61MP0000537_abnormal_urethra_morphology0.27698207
62MP0003329_amyloid_beta_deposits0.26841061
63MP0003300_gastrointestinal_ulcer0.26153507
64MP0001879_abnormal_lymphatic_vessel0.24718876
65MP0003763_abnormal_thymus_physiology0.24635854
66MP0003950_abnormal_plasma_membrane0.24622348
67MP0000465_gastrointestinal_hemorrhage0.24442411
68MP0002177_abnormal_outer_ear0.23508667
69MP0002697_abnormal_eye_size0.23385059
70MP0004019_abnormal_vitamin_homeostasis0.21972507
71MP0006054_spinal_hemorrhage0.21916575
72MP0005248_abnormal_Harderian_gland0.21911258
73MP0004742_abnormal_vestibular_system0.21360099
74MP0004858_abnormal_nervous_system0.19460174
75MP0000432_abnormal_head_morphology0.16880903
76MP0003935_abnormal_craniofacial_develop0.16023154
77MP0003448_altered_tumor_morphology0.15724933
78MP0005375_adipose_tissue_phenotype0.15715883
79MP0003011_delayed_dark_adaptation0.14793516
80MP0000516_abnormal_urinary_system0.14415549
81MP0005367_renal/urinary_system_phenotyp0.14415549
82MP0005666_abnormal_adipose_tissue0.14393225
83MP0000604_amyloidosis0.13923186
84MP0003638_abnormal_response/metabolism_0.13884317
85MP0003075_altered_response_to0.12864078
86MP0002233_abnormal_nose_morphology0.11797822
87MP0005076_abnormal_cell_differentiation0.11699310
88MP0000751_myopathy0.11674557
89MP0010368_abnormal_lymphatic_system0.11362398
90MP0000733_abnormal_muscle_development0.11278843
91MP0005623_abnormal_meninges_morphology0.10407468
92MP0008569_lethality_at_weaning0.10140867
93MP0000462_abnormal_digestive_system0.10120826
94MP0000013_abnormal_adipose_tissue0.10012872
95MP0003045_fibrosis0.09742917
96MP0006138_congestive_heart_failure0.09199957
97MP0005193_abnormal_anterior_eye0.09173106
98MP0001958_emphysema0.08668454
99MP0009384_cardiac_valve_regurgitation0.07020002
100MP0005165_increased_susceptibility_to0.06479736

Predicted human phenotypes

RankGene SetZ-score
1Brittle hair (HP:0002299)9.81802022
2Pili torti (HP:0003777)9.51875589
3Nail dystrophy (HP:0008404)7.08847765
4Abnormality of nail color (HP:0100643)6.32946782
5Abnormal hair laboratory examination (HP:0003328)6.01128508
6Fragile nails (HP:0001808)5.58163057
7Fine hair (HP:0002213)5.12849718
8Onycholysis (HP:0001806)5.11390426
9Alopecia of scalp (HP:0002293)4.89217573
10Increased IgE level (HP:0003212)4.79627641
11Palmoplantar hyperkeratosis (HP:0000972)4.75491365
12Thick nail (HP:0001805)4.54375178
13Right ventricular cardiomyopathy (HP:0011663)4.48806216
14Palmar hyperkeratosis (HP:0010765)4.46904494
15Follicular hyperkeratosis (HP:0007502)4.45341379
16Plantar hyperkeratosis (HP:0007556)4.33094462
17Sparse eyelashes (HP:0000653)3.68703660
18Erythema (HP:0010783)3.53950690
19Oral leukoplakia (HP:0002745)3.52541769
20Amelogenesis imperfecta (HP:0000705)3.21217046
21Milia (HP:0001056)3.16608933
22Abnormality of the frontal sinuses (HP:0002687)3.14209984
23Parakeratosis (HP:0001036)2.89176046
24Curly hair (HP:0002212)2.79403522
25Intention tremor (HP:0002080)2.77838958
26Congenital, generalized hypertrichosis (HP:0004540)2.76864189
27Erythroderma (HP:0001019)2.72617227
28Ridged nail (HP:0001807)2.62946867
29Neck muscle weakness (HP:0000467)2.59514904
30Torticollis (HP:0000473)2.52529518
31Natal tooth (HP:0000695)2.50658082
32Aplasia cutis congenita (HP:0001057)2.47044508
33Advanced eruption of teeth (HP:0006288)2.45467562
34Abnormal blistering of the skin (HP:0008066)2.38042936
35Dry hair (HP:0011359)2.30013242
36Congenital ichthyosiform erythroderma (HP:0007431)2.23537962
37Ventricular tachycardia (HP:0004756)2.14564420
38Craniofacial dystonia (HP:0012179)2.13238536
39Hypohidrosis (HP:0000966)2.04863726
40Difficulty walking (HP:0002355)2.02340395
41Hypotrichosis (HP:0001006)14.3528991
42Woolly hair (HP:0002224)11.5453813
43Abnormality of hair growth rate (HP:0011363)10.8233461
44Slow-growing hair (HP:0002217)10.8233461
45Corneal erosion (HP:0200020)1.99872038
46Palmoplantar keratoderma (HP:0000982)1.95395692
47Focal dystonia (HP:0004373)1.95311066
48Pruritus (HP:0000989)1.93972367
49Ventricular fibrillation (HP:0001663)1.91439208
50Abnormality of the pupil (HP:0000615)1.88942946
51Abnormality of the dental root (HP:0006486)1.82236569
52Taurodontia (HP:0000679)1.82236569
53Abnormality of permanent molar morphology (HP:0011071)1.82236569
54Abnormality of molar morphology (HP:0011070)1.78743324
55Abnormality of molar (HP:0011077)1.78743324
56Abnormality of the parietal bone (HP:0002696)1.76972295
57Abnormality of dental color (HP:0011073)1.75914590
58Absent eyelashes (HP:0000561)1.68961250
59Concave nail (HP:0001598)1.68878166
60Widely patent fontanelles and sutures (HP:0004492)1.66721695
61Unilateral renal agenesis (HP:0000122)1.66422373
62Recurrent corneal erosions (HP:0000495)1.65783482
63Abnormality of the aortic arch (HP:0012303)1.63031369
64Abnormality of the neuromuscular junction (HP:0003398)1.61212358
65Fatigable weakness (HP:0003473)1.61212358
66Abnormality of the dental pulp (HP:0006479)1.59922298
67Blepharitis (HP:0000498)1.57086083
68Sudden death (HP:0001699)1.56478159
69Hyporeflexia of lower limbs (HP:0002600)1.53994844
70Amniotic constriction ring (HP:0009775)1.51145863
71Abnormality of placental membranes (HP:0011409)1.51145863
72Acanthosis nigricans (HP:0000956)1.48589001
73Hypergammaglobulinemia (HP:0010702)1.41718566
74Carious teeth (HP:0000670)1.41389236
75Anonychia (HP:0001798)1.40180491
76Heterogeneous (HP:0001425)1.36577749
77Craniofacial hyperostosis (HP:0004493)1.35804248
78Lip pit (HP:0100267)1.35659770
79Keratoconjunctivitis sicca (HP:0001097)1.32861132
80Autoamputation (HP:0001218)1.31392719
81Achilles tendon contracture (HP:0001771)1.30101491
82Laryngomalacia (HP:0001601)1.29215373
83Distal lower limb muscle weakness (HP:0009053)1.27269241
84Selective tooth agenesis (HP:0001592)1.26211408
85Neonatal onset (HP:0003623)1.26126695
86Abnormality of the fingernails (HP:0001231)1.24765282
87Ectropion (HP:0000656)1.24504911
88Abnormality of the Achilles tendon (HP:0005109)1.22856838
89Widely spaced teeth (HP:0000687)1.22759535
90Round ear (HP:0100830)1.20869806
91Conjunctival hamartoma (HP:0100780)1.20653314
92Gangrene (HP:0100758)1.18019118
93Sparse scalp hair (HP:0002209)1.17869314
94Abnormality of the gastric mucosa (HP:0004295)1.17419058
95Keratoconjunctivitis (HP:0001096)1.16333487
96Bronchomalacia (HP:0002780)1.15095397
97Type 1 muscle fiber predominance (HP:0003803)1.14059388
98Increased connective tissue (HP:0009025)1.12542260
99Variable expressivity (HP:0003828)1.12519293
100Corneal dystrophy (HP:0001131)1.11921337

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FER4.45878583
2EPHA24.17956990
3MAP3K63.97685145
4ERN13.87168356
5MAPKAPK33.73333377
6EPHB23.19604435
7TAOK13.10105232
8TRIB32.76804243
9MAP3K32.60475961
10MAP3K22.29329396
11LATS12.08629454
12MAP3K112.03447769
13EEF2K1.98400343
14EPHB11.91939665
15TTN1.91388070
16RPS6KB21.86421484
17PIK3CG1.85967150
18LATS21.48887276
19FGFR41.46560505
20MAP2K61.44444204
21BCR1.39746813
22RIPK11.34470640
23MAP3K11.32146012
24BMX1.27958643
25PKN21.23513335
26NME11.21412618
27SIK11.19559574
28KSR21.17492965
29CDK61.14676281
30MAP2K31.12889020
31PDGFRA1.09305603
32BLK1.08459037
33FGFR31.08071257
34MAPKAPK21.04965816
35PTK61.04791390
36FGFR21.03528019
37MAP3K71.00946706
38LRRK21.00236724
39MST1R0.93746341
40PTK20.87254428
41FGFR10.86558309
42MAP3K90.86368056
43MAP2K40.85732750
44OBSCN0.84502117
45MAP3K100.81236511
46PAK30.72567442
47PAK40.72416565
48MAP2K10.72245701
49CDK190.72093016
50RPS6KA40.71959080
51PRKD10.71912912
52STK380.71484823
53PBK0.66610607
54DYRK1B0.66051048
55DDR20.64447449
56MET0.63135879
57TYK20.61378133
58PIM20.61147079
59JAK10.59645054
60PRKCH0.57290573
61PAK20.57258719
62EPHA30.56403563
63TESK10.55604054
64PAK60.55305276
65RET0.54594037
66PRKCI0.53445709
67TRPM70.51521448
68ERBB20.51385956
69MAPK120.51071968
70TYRO30.49533414
71CLK10.49136261
72NTRK20.48414137
73ERBB40.46631718
74TGFBR10.46039670
75STK38L0.45953883
76RPS6KA10.45816569
77ALK0.44806553
78MAP3K50.41913615
79GSK3A0.40719966
80GRK60.39128026
81CSNK1E0.38529752
82FYN0.36993087
83JAK20.36635824
84NEK10.36218093
85MAP3K80.33318084
86MAP2K20.32482421
87TGFBR20.31476226
88PHKG10.31127386
89PHKG20.31127386
90MST40.30366840
91FES0.29324250
92STK110.28891298
93MATK0.27663271
94SRC0.27487778
95NTRK10.26165868
96HCK0.25796930
97PRKACG0.23691398
98TNK20.23600613
99ILK0.23446299
100CSNK1A10.23351575

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.64222075
2Linoleic acid metabolism_Homo sapiens_hsa005914.58774567
3Fat digestion and absorption_Homo sapiens_hsa049753.17014066
4Fatty acid elongation_Homo sapiens_hsa000622.79267738
5Ether lipid metabolism_Homo sapiens_hsa005652.44421037
6Basal cell carcinoma_Homo sapiens_hsa052172.19084506
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.99841130
8Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.84679245
9Phenylalanine metabolism_Homo sapiens_hsa003601.80079282
10Arachidonic acid metabolism_Homo sapiens_hsa005901.69113684
11VEGF signaling pathway_Homo sapiens_hsa043701.61618132
12Axon guidance_Homo sapiens_hsa043601.59205027
13Caffeine metabolism_Homo sapiens_hsa002321.56328728
14Melanogenesis_Homo sapiens_hsa049161.53984346
15Histidine metabolism_Homo sapiens_hsa003401.31829979
16Hedgehog signaling pathway_Homo sapiens_hsa043401.31452907
17Glioma_Homo sapiens_hsa052141.29422868
18Vascular smooth muscle contraction_Homo sapiens_hsa042701.26659801
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.26225429
20Acute myeloid leukemia_Homo sapiens_hsa052211.25629427
21Proteoglycans in cancer_Homo sapiens_hsa052051.25461031
22Bladder cancer_Homo sapiens_hsa052191.23891808
23Thyroid cancer_Homo sapiens_hsa052161.23218315
24Hippo signaling pathway_Homo sapiens_hsa043901.20114601
25Dorso-ventral axis formation_Homo sapiens_hsa043201.16651604
26Nitrogen metabolism_Homo sapiens_hsa009101.14723746
27GnRH signaling pathway_Homo sapiens_hsa049121.13363854
28Tight junction_Homo sapiens_hsa045301.13149615
29Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.09467621
30Pancreatic secretion_Homo sapiens_hsa049721.08091921
31PPAR signaling pathway_Homo sapiens_hsa033201.07751383
32Mineral absorption_Homo sapiens_hsa049781.07140778
33Steroid biosynthesis_Homo sapiens_hsa001001.07046640
34Adherens junction_Homo sapiens_hsa045201.02604784
35Long-term potentiation_Homo sapiens_hsa047200.98161611
36ECM-receptor interaction_Homo sapiens_hsa045120.97677836
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93012305
38Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85953803
39Tyrosine metabolism_Homo sapiens_hsa003500.85557254
40Glycerophospholipid metabolism_Homo sapiens_hsa005640.85282940
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.84137193
42Endometrial cancer_Homo sapiens_hsa052130.82977973
43Non-small cell lung cancer_Homo sapiens_hsa052230.82458656
44Leukocyte transendothelial migration_Homo sapiens_hsa046700.82109880
45Ras signaling pathway_Homo sapiens_hsa040140.80401717
46Estrogen signaling pathway_Homo sapiens_hsa049150.80392558
47Long-term depression_Homo sapiens_hsa047300.80349939
48Amoebiasis_Homo sapiens_hsa051460.79501326
49beta-Alanine metabolism_Homo sapiens_hsa004100.78908135
50Pertussis_Homo sapiens_hsa051330.78880169
51Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.78781252
52Wnt signaling pathway_Homo sapiens_hsa043100.74288907
53Gastric acid secretion_Homo sapiens_hsa049710.70931087
54Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66772915
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65528138
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.64929344
57Renin secretion_Homo sapiens_hsa049240.64341979
58Insulin resistance_Homo sapiens_hsa049310.63519328
59Fatty acid metabolism_Homo sapiens_hsa012120.62986019
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61625729
61Salivary secretion_Homo sapiens_hsa049700.59197079
62Sphingolipid signaling pathway_Homo sapiens_hsa040710.58819836
63Staphylococcus aureus infection_Homo sapiens_hsa051500.57657613
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57547080
65Gap junction_Homo sapiens_hsa045400.57225213
66Rap1 signaling pathway_Homo sapiens_hsa040150.56898422
67MicroRNAs in cancer_Homo sapiens_hsa052060.56224463
68Hepatitis C_Homo sapiens_hsa051600.55619604
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.54591976
70Salmonella infection_Homo sapiens_hsa051320.53555377
71Focal adhesion_Homo sapiens_hsa045100.53216614
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.52262321
73Renal cell carcinoma_Homo sapiens_hsa052110.51238384
74Oxytocin signaling pathway_Homo sapiens_hsa049210.50104883
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.49281536
76Phototransduction_Homo sapiens_hsa047440.49266792
77Butanoate metabolism_Homo sapiens_hsa006500.48134894
78ErbB signaling pathway_Homo sapiens_hsa040120.47838567
79Fatty acid degradation_Homo sapiens_hsa000710.47592529
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47586230
81Platelet activation_Homo sapiens_hsa046110.47049086
82Protein digestion and absorption_Homo sapiens_hsa049740.43140519
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43004394
84Prion diseases_Homo sapiens_hsa050200.42910320
85Notch signaling pathway_Homo sapiens_hsa043300.42432932
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41685581
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40851247
88Arginine biosynthesis_Homo sapiens_hsa002200.40281605
89Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.39641748
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.39286646
91Toxoplasmosis_Homo sapiens_hsa051450.38883196
92Chemical carcinogenesis_Homo sapiens_hsa052040.38881191
93TGF-beta signaling pathway_Homo sapiens_hsa043500.38492784
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37904870
95Bile secretion_Homo sapiens_hsa049760.37631536
96Olfactory transduction_Homo sapiens_hsa047400.37015053
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36688736
98Prolactin signaling pathway_Homo sapiens_hsa049170.36427299
99Chronic myeloid leukemia_Homo sapiens_hsa052200.36361799
100Tuberculosis_Homo sapiens_hsa051520.36030150

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