KRTAP4-1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This protein is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the ultrahigh sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1citrulline biosynthetic process (GO:0019240)9.04360843
2adhesion of symbiont to host (GO:0044406)8.65318764
3peptide cross-linking (GO:0018149)8.50490393
4hair follicle morphogenesis (GO:0031069)8.21417258
5intermediate filament cytoskeleton organization (GO:0045104)6.80741531
6intermediate filament-based process (GO:0045103)6.59143959
7epidermis development (GO:0008544)6.09394983
8citrulline metabolic process (GO:0000052)5.99422800
9cell wall macromolecule catabolic process (GO:0016998)5.91714157
10cell wall macromolecule metabolic process (GO:0044036)5.91714157
11keratinocyte differentiation (GO:0030216)5.82744942
12establishment of skin barrier (GO:0061436)5.71803909
13bundle of His cell to Purkinje myocyte communication (GO:0086069)5.31144101
14hair cycle process (GO:0022405)5.27588434
15molting cycle process (GO:0022404)5.27588434
16regulation of water loss via skin (GO:0033561)5.06879558
17hemidesmosome assembly (GO:0031581)5.05662133
18peptidyl-arginine modification (GO:0018195)5.00213378
19skin morphogenesis (GO:0043589)4.98177737
20epidermal cell differentiation (GO:0009913)4.53455708
21molting cycle (GO:0042303)35.0447251
22hair cycle (GO:0042633)35.0447251
23keratinocyte development (GO:0003334)3.76516480
24tooth mineralization (GO:0034505)3.74104257
25multicellular organismal water homeostasis (GO:0050891)3.41322391
26negative regulation of keratinocyte proliferation (GO:0010839)3.35777057
27phosphatidylinositol acyl-chain remodeling (GO:0036149)3.31315170
28negative regulation of establishment of protein localization to plasma membrane (GO:0090005)3.25634305
29positive regulation of hair follicle development (GO:0051798)3.10694661
30positive regulation of hair cycle (GO:0042635)3.10694661
31regulation of keratinocyte differentiation (GO:0045616)3.10341936
32hair follicle development (GO:0001942)3.10113943
33phosphatidylserine acyl-chain remodeling (GO:0036150)3.03536801
34regulation of hair follicle development (GO:0051797)2.92430130
35ectoderm development (GO:0007398)2.92262146
36epithelium development (GO:0060429)2.87948377
37water homeostasis (GO:0030104)2.79474154
38gap junction assembly (GO:0016264)2.77012667
39phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.76605816
40fatty acid elongation (GO:0030497)2.72480494
41negative regulation of protein localization to plasma membrane (GO:1903077)2.69922678
42atrioventricular valve morphogenesis (GO:0003181)2.68861284
43positive regulation of epidermis development (GO:0045684)2.68501211
44bone trabecula formation (GO:0060346)2.66526736
45regulation of hair cycle (GO:0042634)2.61702465
46positive regulation of meiotic cell cycle (GO:0051446)2.55875947
47ventricular cardiac muscle cell action potential (GO:0086005)2.46139378
48regulation of epidermal cell differentiation (GO:0045604)2.44172164
49regulation of epidermis development (GO:0045682)2.38747297
50negative regulation of cell fate specification (GO:0009996)2.35169238
51phosphatidylserine metabolic process (GO:0006658)2.29687028
52epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.27267679
53positive regulation of epidermal cell differentiation (GO:0045606)2.22054106
54phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.21052394
55lymph vessel development (GO:0001945)2.20504352
56regulation of mesenchymal cell apoptotic process (GO:2001053)2.16300214
57skin development (GO:0043588)2.16148542
58cell surface receptor signaling pathway involved in heart development (GO:0061311)2.14172237
59positive regulation of monocyte chemotaxis (GO:0090026)2.10511270
60regulation of cardioblast differentiation (GO:0051890)2.09211315
61wound healing, spreading of epidermal cells (GO:0035313)2.07503391
62aging (GO:0007568)2.06642141
63regulation of heart rate by cardiac conduction (GO:0086091)2.05852550
64cytoskeletal anchoring at plasma membrane (GO:0007016)2.04997248
65epithelial cell-cell adhesion (GO:0090136)2.03583065
66intermediate filament organization (GO:0045109)12.3454395
67keratinization (GO:0031424)11.6406872
68virion attachment to host cell (GO:0019062)10.2359713
69adhesion of symbiont to host cell (GO:0044650)10.2359713
70desmosome organization (GO:0002934)10.2217835
71regulation of Wnt signaling pathway involved in heart development (GO:0003307)1.97073786
72cranial suture morphogenesis (GO:0060363)1.95302964
73myotube differentiation (GO:0014902)1.95182998
74phosphatidylcholine acyl-chain remodeling (GO:0036151)1.95155468
75cell communication involved in cardiac conduction (GO:0086065)1.95114604
76regulation of ruffle assembly (GO:1900027)1.91519230
77outflow tract septum morphogenesis (GO:0003148)1.91001979
78planar cell polarity pathway involved in neural tube closure (GO:0090179)1.88892182
79regulation of keratinocyte proliferation (GO:0010837)1.86712892
80cell-substrate junction assembly (GO:0007044)1.84195624
81negative regulation of epidermis development (GO:0045683)1.84091669
82antigen processing and presentation of endogenous peptide antigen (GO:0002483)1.83729183
83antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)1.83729183
84ephrin receptor signaling pathway (GO:0048013)1.78720520
85regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)1.74041810
86non-canonical Wnt signaling pathway (GO:0035567)1.72846151
87coronary vasculature morphogenesis (GO:0060977)1.72237296
88alditol phosphate metabolic process (GO:0052646)1.69962552
89regulation of cardioblast proliferation (GO:0003264)1.68128474
90regulation of secondary heart field cardioblast proliferation (GO:0003266)1.68128474
91very long-chain fatty acid metabolic process (GO:0000038)1.66890660
92primary alcohol catabolic process (GO:0034310)1.65171408
93negative regulation of cell fate commitment (GO:0010454)1.61563703
94cardiac conduction (GO:0061337)1.60919849
95long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)1.60106804
96cardiac muscle cell action potential involved in contraction (GO:0086002)1.55957822
97cellular modified amino acid biosynthetic process (GO:0042398)1.55880761
98regulation of transforming growth factor beta2 production (GO:0032909)1.55497742
99establishment of tissue polarity (GO:0007164)1.55115345
100establishment of planar polarity (GO:0001736)1.55115345

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.21952590
2CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.78247274
3P63_26484246_Chip-Seq_KERATINOCYTES_Human3.54795629
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.68515671
5BMI1_19503595_ChIP-Seq_MEFsC_Mouse2.17926981
6* CTCF_20526341_ChIP-Seq_ESCs_Human2.17899702
7NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse2.16707771
8TP63_17297297_ChIP-ChIP_HaCaT_Human12.8192706
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.93410057
10E2F1_20622854_ChIP-Seq_HELA_Human1.86325595
11EGR1_19032775_ChIP-ChIP_M12_Human1.77901710
12P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.72893084
13VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.72705532
14CSB_26484114_Chip-Seq_FIBROBLAST_Human1.72089131
15SOX9_24532713_ChIP-Seq_HFSC_Mouse1.69107651
16* TAF2_19829295_ChIP-Seq_ESCs_Human1.66996637
17CTCF_27219007_Chip-Seq_Bcells_Human1.60719298
18ERG_20517297_ChIP-Seq_VCAP_Human1.58624326
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.58597882
20* NANOG_20526341_ChIP-Seq_ESCs_Human1.55188611
21P53_21459846_ChIP-Seq_SAOS-2_Human1.55004837
22FOXO3_23340844_ChIP-Seq_DLD1_Human1.53842201
23SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.53184487
24SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.53184487
25LXR_22292898_ChIP-Seq_THP-1_Human1.52300821
26RACK7_27058665_Chip-Seq_MCF-7_Human1.51880059
27TP63_22573176_ChIP-Seq_HFKS_Human1.49997829
28TP53_20018659_ChIP-ChIP_R1E_Mouse1.49856752
29DNAJC2_21179169_ChIP-ChIP_NT2_Human1.49612644
30BCL6_27268052_Chip-Seq_Bcells_Human1.47292221
31YY1_22570637_ChIP-Seq_MALME-3M_Human1.42559427
32ATF3_27146783_Chip-Seq_COLON_Human1.39865738
33UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.37776088
34ESR1_21235772_ChIP-Seq_MCF-7_Human1.37580879
35* MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.37010433
36ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.36956381
37SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.35262252
38ESR2_21235772_ChIP-Seq_MCF-7_Human1.28040076
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.28003610
40PHF8_20622854_ChIP-Seq_HELA_Human1.25813739
41* BCOR_27268052_Chip-Seq_Bcells_Human1.23875877
42KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.23560945
43ARNT_22903824_ChIP-Seq_MCF-7_Human1.21045473
44SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.20879454
45P68_20966046_ChIP-Seq_HELA_Human1.18529830
46SUZ12_27294783_Chip-Seq_ESCs_Mouse1.18514899
47AHR_22903824_ChIP-Seq_MCF-7_Human1.17683533
48KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16645801
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16029106
50ELF1_20517297_ChIP-Seq_JURKAT_Human1.15514703
51CEBPB_22108803_ChIP-Seq_LS180_Human1.14642495
52PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.14448755
53RAC3_21632823_ChIP-Seq_H3396_Human1.12770549
54JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12570974
55GATA3_24758297_ChIP-Seq_MCF-7_Human1.11403385
56E2F1_17053090_ChIP-ChIP_MCF-7_Human1.11360796
57TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08451929
58TP63_23658742_ChIP-Seq_EP156T_Human1.07599514
59P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07238823
60UBF1/2_26484160_Chip-Seq_HMECs_Human1.07178298
61JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06882356
62TRIM28_21343339_ChIP-Seq_HEK293_Human1.06554538
63JARID2_20075857_ChIP-Seq_MESCs_Mouse1.06493073
64ELK4_26923725_Chip-Seq_MESODERM_Mouse1.05459120
65SPI1_20517297_ChIP-Seq_HL60_Human1.01901861
66SA1_27219007_Chip-Seq_ERYTHROID_Human1.01427335
67GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.00118061
68SOX2_21211035_ChIP-Seq_LN229_Human0.99041379
69KLF5_25053715_ChIP-Seq_YYC3_Human0.98511050
70* SMC4_20622854_ChIP-Seq_HELA_Human0.95977150
71SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95796146
72RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.94764451
73ERG_21242973_ChIP-ChIP_JURKAT_Human0.94302870
74EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.94144062
75FOXH1_21741376_ChIP-Seq_ESCs_Human0.92208926
76CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90659290
77* GATA4_25053715_ChIP-Seq_YYC3_Human0.90149740
78GATA6_21074721_ChIP-Seq_CACO-2_Human0.90046360
79TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89441026
80TP53_18474530_ChIP-ChIP_U2OS_Human0.88964978
81RUNX1_27514584_Chip-Seq_MCF-7_Human0.87738658
82RING1B_27294783_Chip-Seq_ESCs_Mouse0.87002152
83RXR_22108803_ChIP-Seq_LS180_Human0.86488950
84* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.86473366
85NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.86280019
86ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.85558809
87CDX2_19796622_ChIP-Seq_MESCs_Mouse0.84373642
88SOX2_20726797_ChIP-Seq_SW620_Human0.84330093
89GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.83519292
90ZNF263_19887448_ChIP-Seq_K562_Human0.81165279
91RNF2_27304074_Chip-Seq_ESCs_Mouse0.80603161
92TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.79341367
93ZFP281_18757296_ChIP-ChIP_E14_Mouse0.78920434
94EZH2_27294783_Chip-Seq_ESCs_Mouse0.78185240
95ELK3_25401928_ChIP-Seq_HUVEC_Human0.76715376
96KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.74910818
97FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.74057004
98VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.73993146
99AR_21572438_ChIP-Seq_LNCaP_Human0.73333014
100SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.73022507

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology7.82848940
2MP0002098_abnormal_vibrissa_morphology7.08374405
3MP0000647_abnormal_sebaceous_gland6.38125409
4MP0002796_impaired_skin_barrier5.95369051
5MP0005275_abnormal_skin_tensile5.14520696
6MP0010234_abnormal_vibrissa_follicle5.06985830
7MP0000383_abnormal_hair_follicle4.53424044
8MP0000377_abnormal_hair_follicle4.06961315
9MP0010678_abnormal_skin_adnexa4.01843155
10MP0003705_abnormal_hypodermis_morpholog3.78379742
11MP0005501_abnormal_skin_physiology3.74335558
12MP0000427_abnormal_hair_cycle3.46084257
13MP0002254_reproductive_system_inflammat2.92264629
14MP0001216_abnormal_epidermal_layer2.68861379
15MP0004381_abnormal_hair_follicle2.63627225
16MP0000367_abnormal_coat/_hair2.35521455
17MP0004947_skin_inflammation2.32645708
18MP0010771_integument_phenotype2.30482553
19MP0003453_abnormal_keratinocyte_physiol2.21766433
20MP0002060_abnormal_skin_morphology2.14722422
21MP0001243_abnormal_dermal_layer2.12163701
22MP0002234_abnormal_pharynx_morphology2.06020174
23MP0000467_abnormal_esophagus_morphology1.88070954
24MP0000762_abnormal_tongue_morphology1.52292249
25MP0009053_abnormal_anal_canal1.50639512
26MP0009931_abnormal_skin_appearance1.49608233
27MP0003566_abnormal_cell_adhesion1.47962080
28MP0005409_darkened_coat_color1.43136665
29MP0003941_abnormal_skin_development1.15365863
30MP0001191_abnormal_skin_condition0.99872973
31MP0004885_abnormal_endolymph0.94619354
32MP0004185_abnormal_adipocyte_glucose0.88730408
33MP0001851_eye_inflammation0.85258012
34MP0004264_abnormal_extraembryonic_tissu0.84772155
35MP0002095_abnormal_skin_pigmentation0.77572176
36MP0001849_ear_inflammation0.69221511
37MP0003315_abnormal_perineum_morphology0.67903170
38MP0008438_abnormal_cutaneous_collagen0.66812721
39MP0001340_abnormal_eyelid_morphology0.63221389
40MP0002877_abnormal_melanocyte_morpholog0.61930649
41MP0001346_abnormal_lacrimal_gland0.60962846
42MP0001661_extended_life_span0.60326917
43MP0003191_abnormal_cellular_cholesterol0.57479978
44MP0010030_abnormal_orbit_morphology0.55904765
45MP0005451_abnormal_body_composition0.55888826
46MP0000627_abnormal_mammary_gland0.54578986
47MP0002282_abnormal_trachea_morphology0.53939368
48MP0000566_synostosis0.52443758
49MP0005023_abnormal_wound_healing0.51358696
50MP0003755_abnormal_palate_morphology0.49933688
51MP0002970_abnormal_white_adipose0.46783487
52MP0001784_abnormal_fluid_regulation0.45505983
53MP0002249_abnormal_larynx_morphology0.39693123
54MP0000678_abnormal_parathyroid_gland0.38678821
55MP0002111_abnormal_tail_morphology0.38488732
56MP0005075_abnormal_melanosome_morpholog0.36495889
57MP0009840_abnormal_foam_cell0.34684129
58MP0010352_gastrointestinal_tract_polyps0.33136983
59MP0004272_abnormal_basement_membrane0.32874851
60MP0003385_abnormal_body_wall0.29091081
61MP0000537_abnormal_urethra_morphology0.27984682
62MP0000465_gastrointestinal_hemorrhage0.27858318
63MP0003329_amyloid_beta_deposits0.26995496
64MP0002177_abnormal_outer_ear0.26706180
65MP0003950_abnormal_plasma_membrane0.26466175
66MP0003763_abnormal_thymus_physiology0.26009981
67MP0002697_abnormal_eye_size0.23692602
68MP0005248_abnormal_Harderian_gland0.21904866
69MP0003300_gastrointestinal_ulcer0.21829512
70MP0004019_abnormal_vitamin_homeostasis0.20744429
71MP0006054_spinal_hemorrhage0.18734691
72MP0004742_abnormal_vestibular_system0.18141600
73MP0001879_abnormal_lymphatic_vessel0.18033394
74MP0003448_altered_tumor_morphology0.15958447
75MP0000432_abnormal_head_morphology0.15874357
76MP0003011_delayed_dark_adaptation0.15501489
77MP0005666_abnormal_adipose_tissue0.15339056
78MP0004858_abnormal_nervous_system0.15216820
79MP0000604_amyloidosis0.14705679
80MP0005375_adipose_tissue_phenotype0.14513832
81MP0003935_abnormal_craniofacial_develop0.13557798
82MP0003638_abnormal_response/metabolism_0.12933602
83MP0003075_altered_response_to0.11939531
84MP0005076_abnormal_cell_differentiation0.11044236
85MP0000516_abnormal_urinary_system0.10894072
86MP0005367_renal/urinary_system_phenotyp0.10894072
87MP0005193_abnormal_anterior_eye0.10389739
88MP0002233_abnormal_nose_morphology0.10217697
89MP0010368_abnormal_lymphatic_system0.08980408
90MP0002006_tumorigenesis0.08952317
91MP0003045_fibrosis0.08410566
92MP0008569_lethality_at_weaning0.08022110
93MP0000462_abnormal_digestive_system0.08021603
94MP0000733_abnormal_muscle_development0.07779378
95MP0002166_altered_tumor_susceptibility0.07774263
96MP0001958_emphysema0.07251678
97MP0006138_congestive_heart_failure0.06104081
98MP0002090_abnormal_vision0.06031332
99MP0000013_abnormal_adipose_tissue0.06014184
100MP0005165_increased_susceptibility_to0.05131442

Predicted human phenotypes

RankGene SetZ-score
1Pili torti (HP:0003777)9.11379058
2Nail dystrophy (HP:0008404)7.28717122
3Abnormality of nail color (HP:0100643)6.84543612
4Abnormal hair laboratory examination (HP:0003328)5.76167600
5Fragile nails (HP:0001808)5.62961554
6Fine hair (HP:0002213)5.15322385
7Alopecia of scalp (HP:0002293)5.14326684
8Palmoplantar hyperkeratosis (HP:0000972)5.10667331
9Onycholysis (HP:0001806)5.02892768
10Thick nail (HP:0001805)4.99255713
11Increased IgE level (HP:0003212)4.92342105
12Palmar hyperkeratosis (HP:0010765)4.80838092
13Plantar hyperkeratosis (HP:0007556)4.62936246
14Follicular hyperkeratosis (HP:0007502)4.52499506
15Right ventricular cardiomyopathy (HP:0011663)4.33323955
16Oral leukoplakia (HP:0002745)3.71945695
17Erythema (HP:0010783)3.65011819
18Sparse eyelashes (HP:0000653)3.59258228
19Milia (HP:0001056)3.34243392
20Amelogenesis imperfecta (HP:0000705)3.05242227
21Erythroderma (HP:0001019)3.00402471
22Abnormality of the frontal sinuses (HP:0002687)2.99927529
23Parakeratosis (HP:0001036)2.88371011
24Ridged nail (HP:0001807)2.79571208
25Curly hair (HP:0002212)2.71723383
26Intention tremor (HP:0002080)2.66971627
27Congenital, generalized hypertrichosis (HP:0004540)2.58777050
28Abnormal blistering of the skin (HP:0008066)2.57823125
29Natal tooth (HP:0000695)2.47989337
30Congenital ichthyosiform erythroderma (HP:0007431)2.43269437
31Neck muscle weakness (HP:0000467)2.43014800
32Advanced eruption of teeth (HP:0006288)2.38728015
33Torticollis (HP:0000473)2.36769896
34Aplasia cutis congenita (HP:0001057)2.35716580
35Dry hair (HP:0011359)2.34300777
36Hypohidrosis (HP:0000966)2.15514160
37Palmoplantar keratoderma (HP:0000982)2.09328752
38Corneal erosion (HP:0200020)2.08508901
39Ventricular tachycardia (HP:0004756)2.06569194
40Craniofacial dystonia (HP:0012179)2.00043405
41Hypotrichosis (HP:0001006)14.5350421
42Woolly hair (HP:0002224)11.1429385
43Abnormality of hair growth rate (HP:0011363)10.9028706
44Slow-growing hair (HP:0002217)10.9028706
45Brittle hair (HP:0002299)10.0632952
46Pruritus (HP:0000989)1.94942381
47Difficulty walking (HP:0002355)1.90226604
48Ventricular fibrillation (HP:0001663)1.86607060
49Focal dystonia (HP:0004373)1.82986672
50Abnormality of the pupil (HP:0000615)1.80601306
51Fatigable weakness (HP:0003473)1.78052464
52Abnormality of the neuromuscular junction (HP:0003398)1.78052464
53Abnormality of the dental root (HP:0006486)1.70246577
54Taurodontia (HP:0000679)1.70246577
55Abnormality of permanent molar morphology (HP:0011071)1.70246577
56Conjunctival hamartoma (HP:0100780)1.70074650
57Abnormality of dental color (HP:0011073)1.67799396
58Abnormality of molar morphology (HP:0011070)1.67247870
59Abnormality of molar (HP:0011077)1.67247870
60Abnormality of the parietal bone (HP:0002696)1.66762564
61Concave nail (HP:0001598)1.65815663
62Absent eyelashes (HP:0000561)1.62974478
63Recurrent corneal erosions (HP:0000495)1.61448565
64Widely patent fontanelles and sutures (HP:0004492)1.60843102
65Blepharitis (HP:0000498)1.58331726
66Unilateral renal agenesis (HP:0000122)1.55477790
67Abnormality of the aortic arch (HP:0012303)1.50978399
68Sudden death (HP:0001699)1.49419439
69Hyporeflexia of lower limbs (HP:0002600)1.49186421
70Anonychia (HP:0001798)1.48724518
71Abnormality of the dental pulp (HP:0006479)1.48594086
72Amniotic constriction ring (HP:0009775)1.47971544
73Abnormality of placental membranes (HP:0011409)1.47971544
74Carious teeth (HP:0000670)1.47120064
75Hypergammaglobulinemia (HP:0010702)1.46097032
76Acanthosis nigricans (HP:0000956)1.45203781
77Laryngomalacia (HP:0001601)1.42237308
78Gangrene (HP:0100758)1.40509154
79Heterogeneous (HP:0001425)1.40354108
80Lip pit (HP:0100267)1.37259091
81Ectropion (HP:0000656)1.36255453
82Keratoconjunctivitis sicca (HP:0001097)1.35901293
83Neonatal onset (HP:0003623)1.33168306
84Abnormality of the fingernails (HP:0001231)1.32591522
85Autoamputation (HP:0001218)1.31866593
86Achilles tendon contracture (HP:0001771)1.29801410
87Craniofacial hyperostosis (HP:0004493)1.26942920
88Distal lower limb muscle weakness (HP:0009053)1.25277543
89Hyperhidrosis (HP:0000975)1.22791374
90Corneal dystrophy (HP:0001131)1.22743330
91Abnormality of the Achilles tendon (HP:0005109)1.22221210
92Keratoconjunctivitis (HP:0001096)1.19359613
93Sparse scalp hair (HP:0002209)1.17514885
94Selective tooth agenesis (HP:0001592)1.17348185
95Variable expressivity (HP:0003828)1.16924172
96Atrophic scars (HP:0001075)1.14326687
97Abnormality of the gastric mucosa (HP:0004295)1.14312590
98Lack of skin elasticity (HP:0100679)1.13857991
99Widely spaced teeth (HP:0000687)1.12309322
100Skin ulcer (HP:0200042)1.11120307

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FER4.34528697
2EPHA24.23547912
3ERN13.98130277
4MAPKAPK33.96977427
5MAP3K63.89007822
6EPHB23.08498805
7TAOK13.08300851
8TRIB32.76580125
9MAP3K32.71125052
10MAP3K22.32252012
11LATS12.23982533
12MAP3K112.10389769
13RPS6KB21.92603680
14EEF2K1.92098451
15EPHB11.82850551
16TTN1.70325528
17PIK3CG1.66595884
18MAP2K61.63409881
19LATS21.55352786
20FGFR41.49796235
21BCR1.36285328
22MAP3K11.31878439
23NME11.26754299
24RIPK11.26559031
25PKN21.24797901
26BMX1.23828687
27BLK1.23205583
28KSR21.18106320
29MST1R1.17818644
30MAP2K31.14394075
31CDK61.11720665
32FGFR11.11292470
33FGFR31.09627342
34MAPKAPK21.09295488
35PDGFRA1.08278592
36FGFR21.08266252
37PTK61.02797482
38MAP3K90.99882314
39LRRK20.99865934
40MAP3K70.97133436
41RPS6KA40.87264960
42SIK10.86975061
43PTK20.85694202
44MAP2K40.82613987
45PBK0.79658008
46MAP2K10.75920140
47STK380.72885398
48PAK40.72443147
49MAP3K100.71830796
50TESK10.70866750
51MET0.70225931
52PIM20.70179074
53PAK30.69245863
54PRKD10.68054828
55TYK20.66915329
56DDR20.66075060
57DYRK1B0.64812118
58CDK190.63179021
59JAK10.61926001
60STK38L0.58181146
61EPHA30.57505617
62PRKCH0.55439009
63PRKCI0.54792456
64TYRO30.54401722
65TRPM70.54395805
66PAK20.54094763
67NTRK20.54066254
68PAK60.52386526
69RET0.52218790
70MAP3K50.52174257
71ERBB40.50680232
72OBSCN0.49834019
73ERBB20.48088337
74TGFBR10.47810049
75ALK0.47070405
76RPS6KA10.46690406
77MAPK120.44549638
78CLK10.41318169
79GSK3A0.39816432
80CSNK1E0.37869101
81JAK20.37674509
82GRK60.37426349
83MST40.36426251
84NEK10.35868144
85MAP2K20.35097561
86FYN0.33452155
87MAP3K80.32465881
88TGFBR20.31205310
89LIMK10.28252488
90HCK0.26713019
91ILK0.25833050
92SRC0.25725548
93MAP4K10.24302928
94CSNK1A10.24159585
95STK110.23757439
96PRKACG0.22479493
97MATK0.21807352
98NTRK10.21544927
99ROCK20.21036625
100MAPK80.21027971

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.93521714
2Linoleic acid metabolism_Homo sapiens_hsa005914.88323779
3Fat digestion and absorption_Homo sapiens_hsa049753.23456482
4Fatty acid elongation_Homo sapiens_hsa000622.89261684
5Ether lipid metabolism_Homo sapiens_hsa005652.58344085
6Basal cell carcinoma_Homo sapiens_hsa052172.11139005
7Arachidonic acid metabolism_Homo sapiens_hsa005901.88543881
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.86780095
9Phenylalanine metabolism_Homo sapiens_hsa003601.85804532
10Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.83822540
11VEGF signaling pathway_Homo sapiens_hsa043701.67711750
12Caffeine metabolism_Homo sapiens_hsa002321.53486445
13Axon guidance_Homo sapiens_hsa043601.51282135
14Melanogenesis_Homo sapiens_hsa049161.51036128
15Histidine metabolism_Homo sapiens_hsa003401.36642363
16Glioma_Homo sapiens_hsa052141.30197117
17Hedgehog signaling pathway_Homo sapiens_hsa043401.29247245
18Vascular smooth muscle contraction_Homo sapiens_hsa042701.28622641
19Bladder cancer_Homo sapiens_hsa052191.26729678
20Thyroid cancer_Homo sapiens_hsa052161.26030868
21Proteoglycans in cancer_Homo sapiens_hsa052051.24091956
22Acute myeloid leukemia_Homo sapiens_hsa052211.23796182
23GnRH signaling pathway_Homo sapiens_hsa049121.19016925
24Hippo signaling pathway_Homo sapiens_hsa043901.16883231
25Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14051820
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.12440610
27Steroid biosynthesis_Homo sapiens_hsa001001.10599265
28Pancreatic secretion_Homo sapiens_hsa049721.09847343
29Dorso-ventral axis formation_Homo sapiens_hsa043201.08288255
30PPAR signaling pathway_Homo sapiens_hsa033201.07714364
31Tight junction_Homo sapiens_hsa045301.07235645
32Mineral absorption_Homo sapiens_hsa049781.04943202
33Nitrogen metabolism_Homo sapiens_hsa009101.02085099
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96769862
35ECM-receptor interaction_Homo sapiens_hsa045120.95868683
36Long-term potentiation_Homo sapiens_hsa047200.95813504
37Adherens junction_Homo sapiens_hsa045200.95326605
38Glycerophospholipid metabolism_Homo sapiens_hsa005640.94126209
39Tyrosine metabolism_Homo sapiens_hsa003500.89918577
40Pertussis_Homo sapiens_hsa051330.87822417
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84818295
42Non-small cell lung cancer_Homo sapiens_hsa052230.83459853
43Endometrial cancer_Homo sapiens_hsa052130.82018384
44Ras signaling pathway_Homo sapiens_hsa040140.81316755
45Estrogen signaling pathway_Homo sapiens_hsa049150.81185662
46beta-Alanine metabolism_Homo sapiens_hsa004100.80510081
47Leukocyte transendothelial migration_Homo sapiens_hsa046700.78517590
48Long-term depression_Homo sapiens_hsa047300.78500135
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.77052455
50Amoebiasis_Homo sapiens_hsa051460.76754635
51Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.74495482
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74201868
53Staphylococcus aureus infection_Homo sapiens_hsa051500.72011295
54Wnt signaling pathway_Homo sapiens_hsa043100.69895049
55Gastric acid secretion_Homo sapiens_hsa049710.67659968
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.67059198
57Renin secretion_Homo sapiens_hsa049240.62136255
58Sphingolipid signaling pathway_Homo sapiens_hsa040710.61826845
59Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.61740948
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60430515
61Hepatitis C_Homo sapiens_hsa051600.59474343
62Fatty acid metabolism_Homo sapiens_hsa012120.59272344
63Insulin resistance_Homo sapiens_hsa049310.58645255
64Phototransduction_Homo sapiens_hsa047440.58324783
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58112046
66MicroRNAs in cancer_Homo sapiens_hsa052060.56414236
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.54947980
68Rap1 signaling pathway_Homo sapiens_hsa040150.53871825
69Salmonella infection_Homo sapiens_hsa051320.53773482
70Gap junction_Homo sapiens_hsa045400.52594083
71Salivary secretion_Homo sapiens_hsa049700.50858194
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49800393
73Focal adhesion_Homo sapiens_hsa045100.48307635
74Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47289333
75Renal cell carcinoma_Homo sapiens_hsa052110.46927014
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.46598004
77Platelet activation_Homo sapiens_hsa046110.46094709
78Oxytocin signaling pathway_Homo sapiens_hsa049210.45424483
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45306462
80ErbB signaling pathway_Homo sapiens_hsa040120.45020088
81Fatty acid degradation_Homo sapiens_hsa000710.44567766
82Protein digestion and absorption_Homo sapiens_hsa049740.43586550
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42289277
84Toxoplasmosis_Homo sapiens_hsa051450.42245220
85Butanoate metabolism_Homo sapiens_hsa006500.42196945
86Chemical carcinogenesis_Homo sapiens_hsa052040.41507497
87Tuberculosis_Homo sapiens_hsa051520.40861659
88Prion diseases_Homo sapiens_hsa050200.40291243
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40014508
90Notch signaling pathway_Homo sapiens_hsa043300.38061441
91Prolactin signaling pathway_Homo sapiens_hsa049170.37686884
92Olfactory transduction_Homo sapiens_hsa047400.36955654
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36462471
94Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.36315535
95Chronic myeloid leukemia_Homo sapiens_hsa052200.36259201
96TGF-beta signaling pathway_Homo sapiens_hsa043500.36171454
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.34466512
98Arginine biosynthesis_Homo sapiens_hsa002200.33965487
99Insulin signaling pathway_Homo sapiens_hsa049100.33152312
100Bile secretion_Homo sapiens_hsa049760.31245349

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