KRTAP11-1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)9.99980211
2adhesion of symbiont to host cell (GO:0044650)9.76711310
3virion attachment to host cell (GO:0019062)9.76711310
4citrulline biosynthetic process (GO:0019240)8.95212079
5hair follicle morphogenesis (GO:0031069)8.40040406
6peptide cross-linking (GO:0018149)8.38062483
7adhesion of symbiont to host (GO:0044406)8.23722317
8intermediate filament cytoskeleton organization (GO:0045104)6.63359962
9intermediate filament-based process (GO:0045103)6.42140026
10cell wall macromolecule catabolic process (GO:0016998)6.30170841
11cell wall macromolecule metabolic process (GO:0044036)6.30170841
12epidermis development (GO:0008544)6.18051260
13citrulline metabolic process (GO:0000052)5.91828757
14keratinocyte differentiation (GO:0030216)5.70428118
15establishment of skin barrier (GO:0061436)5.60735717
16molting cycle process (GO:0022404)5.40146936
17hair cycle process (GO:0022405)5.40146936
18regulation of water loss via skin (GO:0033561)4.98894108
19peptidyl-arginine modification (GO:0018195)4.95767228
20bundle of His cell to Purkinje myocyte communication (GO:0086069)4.92619537
21skin morphogenesis (GO:0043589)4.71159454
22hemidesmosome assembly (GO:0031581)4.67614434
23epidermal cell differentiation (GO:0009913)4.46304815
24molting cycle (GO:0042303)34.9418275
25hair cycle (GO:0042633)34.9418275
26tooth mineralization (GO:0034505)3.92704920
27keratinocyte development (GO:0003334)3.87762623
28regulation of keratinocyte differentiation (GO:0045616)3.37896834
29multicellular organismal water homeostasis (GO:0050891)3.35894578
30negative regulation of keratinocyte proliferation (GO:0010839)3.35070787
31phosphatidylinositol acyl-chain remodeling (GO:0036149)3.33940924
32positive regulation of hair follicle development (GO:0051798)3.27549538
33positive regulation of hair cycle (GO:0042635)3.27549538
34hair follicle development (GO:0001942)3.18569845
35negative regulation of establishment of protein localization to plasma membrane (GO:0090005)3.11139484
36phosphatidylserine acyl-chain remodeling (GO:0036150)3.05645212
37regulation of hair follicle development (GO:0051797)3.04618106
38bone trabecula formation (GO:0060346)2.96335258
39epithelium development (GO:0060429)2.92809977
40positive regulation of meiotic cell cycle (GO:0051446)2.83827085
41phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.82207240
42gap junction assembly (GO:0016264)2.81856794
43water homeostasis (GO:0030104)2.75270789
44positive regulation of epidermis development (GO:0045684)2.72593110
45regulation of hair cycle (GO:0042634)2.72132566
46regulation of epidermal cell differentiation (GO:0045604)2.61597968
47fatty acid elongation (GO:0030497)2.59451018
48negative regulation of protein localization to plasma membrane (GO:1903077)2.57267435
49ectoderm development (GO:0007398)2.54224980
50atrioventricular valve morphogenesis (GO:0003181)2.53904560
51regulation of epidermis development (GO:0045682)2.50556295
52epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.50314288
53phosphatidylserine metabolic process (GO:0006658)2.32434648
54ventricular cardiac muscle cell action potential (GO:0086005)2.29653399
55wound healing, spreading of epidermal cells (GO:0035313)2.26844331
56regulation of mesenchymal cell apoptotic process (GO:2001053)2.25547759
57positive regulation of monocyte chemotaxis (GO:0090026)2.25042627
58phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.23545526
59cell surface receptor signaling pathway involved in heart development (GO:0061311)2.23492682
60negative regulation of cell fate specification (GO:0009996)2.23158495
61positive regulation of epidermal cell differentiation (GO:0045606)2.22385853
62cranial suture morphogenesis (GO:0060363)2.20471188
63lymph vessel development (GO:0001945)2.16513716
64skin development (GO:0043588)2.08966308
65regulation of ruffle assembly (GO:1900027)2.06603767
66aging (GO:0007568)2.05338105
67myotube differentiation (GO:0014902)2.04056774
68negative regulation of epidermis development (GO:0045683)2.03710402
69intermediate filament organization (GO:0045109)12.0739931
70keratinization (GO:0031424)11.5896428
71outflow tract septum morphogenesis (GO:0003148)1.99097096
72epithelial cell-cell adhesion (GO:0090136)1.97655432
73phosphatidylcholine acyl-chain remodeling (GO:0036151)1.97581321
74regulation of cardioblast differentiation (GO:0051890)1.96818468
75cytoskeletal anchoring at plasma membrane (GO:0007016)1.92710994
76planar cell polarity pathway involved in neural tube closure (GO:0090179)1.91613173
77regulation of heart rate by cardiac conduction (GO:0086091)1.90919546
78regulation of keratinocyte proliferation (GO:0010837)1.88696491
79ephrin receptor signaling pathway (GO:0048013)1.87823645
80cell communication involved in cardiac conduction (GO:0086065)1.82292000
81non-canonical Wnt signaling pathway (GO:0035567)1.80224096
82regulation of Wnt signaling pathway involved in heart development (GO:0003307)1.79848191
83regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)1.76171067
84regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901211.73790288
85cell-substrate junction assembly (GO:0007044)1.73705592
86alditol phosphate metabolic process (GO:0052646)1.71494944
87primary alcohol catabolic process (GO:0034310)1.68696898
88very long-chain fatty acid metabolic process (GO:0000038)1.65100919
89negative regulation of epidermal cell differentiation (GO:0045605)1.65090109
90coronary vasculature morphogenesis (GO:0060977)1.64605859
91regulation of cardioblast proliferation (GO:0003264)1.62306067
92regulation of secondary heart field cardioblast proliferation (GO:0003266)1.62306067
93regulation of monocyte chemotaxis (GO:0090025)1.61307789
94cardiac right ventricle morphogenesis (GO:0003215)1.60714184
95wound healing, spreading of cells (GO:0044319)1.58872310
96establishment of tissue polarity (GO:0007164)1.58422127
97establishment of planar polarity (GO:0001736)1.58422127
98craniofacial suture morphogenesis (GO:0097094)1.58073092
99cellular modified amino acid biosynthetic process (GO:0042398)1.56832828
100response to UV-B (GO:0010224)1.56780577

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.65612496
2CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human5.06125684
3P63_26484246_Chip-Seq_KERATINOCYTES_Human3.59240572
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.66721254
5CTCF_20526341_ChIP-Seq_ESCs_Human2.39615566
6BMI1_19503595_ChIP-Seq_MEFsC_Mouse2.13843490
7* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse2.01694893
8TP63_17297297_ChIP-ChIP_HaCaT_Human12.4193686
9TAF2_19829295_ChIP-Seq_ESCs_Human1.85850711
10E2F1_20622854_ChIP-Seq_HELA_Human1.85293543
11PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.85273707
12P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.77821683
13VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.76948097
14CSB_26484114_Chip-Seq_FIBROBLAST_Human1.75662532
15NANOG_20526341_ChIP-Seq_ESCs_Human1.72871352
16EGR1_19032775_ChIP-ChIP_M12_Human1.71905406
17ERG_20517297_ChIP-Seq_VCAP_Human1.68511411
18SOX9_24532713_ChIP-Seq_HFSC_Mouse1.68470213
19CTCF_27219007_Chip-Seq_Bcells_Human1.63618231
20P53_21459846_ChIP-Seq_SAOS-2_Human1.62950002
21TP53_20018659_ChIP-ChIP_R1E_Mouse1.56637232
22BCL6_27268052_Chip-Seq_Bcells_Human1.54808980
23RACK7_27058665_Chip-Seq_MCF-7_Human1.53221144
24FOXO3_23340844_ChIP-Seq_DLD1_Human1.52763233
25YY1_22570637_ChIP-Seq_MALME-3M_Human1.52040959
26LXR_22292898_ChIP-Seq_THP-1_Human1.51344469
27TP63_22573176_ChIP-Seq_HFKS_Human1.50180736
28DNAJC2_21179169_ChIP-ChIP_NT2_Human1.49496311
29SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.46516415
30SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.46516415
31MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.45078452
32BCOR_27268052_Chip-Seq_Bcells_Human1.44370022
33ESR1_21235772_ChIP-Seq_MCF-7_Human1.38796653
34UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.38145922
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.37681206
36ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.36176616
37ATF3_27146783_Chip-Seq_COLON_Human1.35733847
38PHF8_20622854_ChIP-Seq_HELA_Human1.29425351
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.28216716
40ELF1_20517297_ChIP-Seq_JURKAT_Human1.26830185
41SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.26109285
42SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.25545904
43ARNT_22903824_ChIP-Seq_MCF-7_Human1.25236470
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.24635818
45P68_20966046_ChIP-Seq_HELA_Human1.24053264
46AHR_22903824_ChIP-Seq_MCF-7_Human1.23136693
47KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20918445
48CEBPB_22108803_ChIP-Seq_LS180_Human1.19990960
49SUZ12_27294783_Chip-Seq_ESCs_Mouse1.19653444
50PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.19618684
51KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16477628
52ELK4_26923725_Chip-Seq_MESODERM_Mouse1.16388638
53TRIM28_21343339_ChIP-Seq_HEK293_Human1.15785203
54IKZF1_21737484_ChIP-ChIP_HCT116_Human1.14063296
55GATA3_24758297_ChIP-Seq_MCF-7_Human1.09685900
56SMC4_20622854_ChIP-Seq_HELA_Human1.08816898
57JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08554596
58SA1_27219007_Chip-Seq_ERYTHROID_Human1.06355970
59GATA4_25053715_ChIP-Seq_YYC3_Human1.06189335
60UBF1/2_26484160_Chip-Seq_HMECs_Human1.05820153
61JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05339513
62P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05179094
63JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04806102
64TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02269695
65SPI1_20517297_ChIP-Seq_HL60_Human1.01356363
66* TP63_23658742_ChIP-Seq_EP156T_Human1.01294029
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00175574
68* E2F1_17053090_ChIP-ChIP_MCF-7_Human0.99252419
69GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.98245681
70TP53_18474530_ChIP-ChIP_U2OS_Human0.97874683
71RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97351529
72CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96050369
73RXRA_24833708_ChIP-Seq_LIVER_Mouse0.95965176
74FOXH1_21741376_ChIP-Seq_ESCs_Human0.95907712
75* RAC3_21632823_ChIP-Seq_H3396_Human0.95571387
76KLF5_25053715_ChIP-Seq_YYC3_Human0.94682528
77ERG_21242973_ChIP-ChIP_JURKAT_Human0.93592297
78SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92441834
79TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91064202
80* SOX2_21211035_ChIP-Seq_LN229_Human0.91018008
81GATA6_21074721_ChIP-Seq_CACO-2_Human0.89573869
82ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.87845341
83RXR_22108803_ChIP-Seq_LS180_Human0.86649653
84RUNX1_27514584_Chip-Seq_MCF-7_Human0.86341471
85NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.82472738
86ZNF263_19887448_ChIP-Seq_K562_Human0.81677632
87SOX2_20726797_ChIP-Seq_SW620_Human0.81591883
88RNF2_27304074_Chip-Seq_ESCs_Mouse0.80880673
89EZH2_27294783_Chip-Seq_ESCs_Mouse0.79483562
90CDX2_19796622_ChIP-Seq_MESCs_Mouse0.79131634
91ZFP281_18757296_ChIP-ChIP_E14_Mouse0.79040694
92AR_21572438_ChIP-Seq_LNCaP_Human0.77669580
93* RING1B_27294783_Chip-Seq_ESCs_Mouse0.76058350
94VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.75732320
95ELK3_25401928_ChIP-Seq_HUVEC_Human0.75619421
96TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.75017603
97KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.74080382
98GATA3_21878914_ChIP-Seq_MCF-7_Human0.73674107
99FOXA1_25329375_ChIP-Seq_VCAP_Human0.73255641
100FOXA1_27270436_Chip-Seq_PROSTATE_Human0.73255641

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology7.47655211
2MP0002098_abnormal_vibrissa_morphology7.33820818
3MP0000647_abnormal_sebaceous_gland6.54161546
4MP0002796_impaired_skin_barrier5.93417941
5MP0010234_abnormal_vibrissa_follicle5.19597323
6MP0005275_abnormal_skin_tensile5.08866553
7MP0000383_abnormal_hair_follicle4.48605273
8MP0000377_abnormal_hair_follicle4.10594973
9MP0010678_abnormal_skin_adnexa3.99463388
10MP0003705_abnormal_hypodermis_morpholog3.73320353
11MP0005501_abnormal_skin_physiology3.70679539
12MP0000427_abnormal_hair_cycle3.49259977
13MP0002254_reproductive_system_inflammat3.15499536
14MP0001216_abnormal_epidermal_layer2.65418944
15MP0004381_abnormal_hair_follicle2.43534225
16MP0000367_abnormal_coat/_hair2.40464130
17MP0010771_integument_phenotype2.30111272
18MP0004947_skin_inflammation2.26148823
19MP0002060_abnormal_skin_morphology2.18086526
20MP0001243_abnormal_dermal_layer2.16153970
21MP0003453_abnormal_keratinocyte_physiol2.15179998
22MP0002234_abnormal_pharynx_morphology2.04851475
23MP0000467_abnormal_esophagus_morphology1.65818459
24MP0009053_abnormal_anal_canal1.54793314
25MP0009931_abnormal_skin_appearance1.50536226
26MP0000762_abnormal_tongue_morphology1.46299711
27MP0003566_abnormal_cell_adhesion1.43044362
28MP0003941_abnormal_skin_development1.20687656
29MP0005409_darkened_coat_color1.11768488
30MP0004885_abnormal_endolymph0.99666570
31MP0001191_abnormal_skin_condition0.98826540
32MP0004185_abnormal_adipocyte_glucose0.96219354
33MP0004264_abnormal_extraembryonic_tissu0.90212281
34MP0001851_eye_inflammation0.76046383
35MP0002095_abnormal_skin_pigmentation0.75148285
36MP0003315_abnormal_perineum_morphology0.70881880
37MP0008438_abnormal_cutaneous_collagen0.69406225
38MP0001346_abnormal_lacrimal_gland0.67357535
39MP0001340_abnormal_eyelid_morphology0.65037665
40MP0002877_abnormal_melanocyte_morpholog0.64889557
41MP0001849_ear_inflammation0.64575366
42MP0010030_abnormal_orbit_morphology0.63437319
43MP0000566_synostosis0.60741844
44MP0000627_abnormal_mammary_gland0.57550214
45MP0001661_extended_life_span0.53761207
46MP0003191_abnormal_cellular_cholesterol0.52884115
47MP0002282_abnormal_trachea_morphology0.49415794
48MP0003755_abnormal_palate_morphology0.48421976
49MP0005451_abnormal_body_composition0.47964346
50MP0005023_abnormal_wound_healing0.47054000
51MP0002970_abnormal_white_adipose0.46773840
52MP0001784_abnormal_fluid_regulation0.44824367
53MP0002111_abnormal_tail_morphology0.41147553
54MP0002249_abnormal_larynx_morphology0.40275100
55MP0010352_gastrointestinal_tract_polyps0.35112937
56MP0000678_abnormal_parathyroid_gland0.34512356
57MP0009840_abnormal_foam_cell0.33126614
58MP0005075_abnormal_melanosome_morpholog0.32988157
59MP0003385_abnormal_body_wall0.32762002
60MP0000537_abnormal_urethra_morphology0.32269745
61MP0004272_abnormal_basement_membrane0.32263647
62MP0002177_abnormal_outer_ear0.26940913
63MP0003329_amyloid_beta_deposits0.26664088
64MP0003763_abnormal_thymus_physiology0.26062878
65MP0003950_abnormal_plasma_membrane0.25830499
66MP0000465_gastrointestinal_hemorrhage0.23749328
67MP0002697_abnormal_eye_size0.22978131
68MP0005248_abnormal_Harderian_gland0.22803419
69MP0004019_abnormal_vitamin_homeostasis0.20044638
70MP0006054_spinal_hemorrhage0.19471997
71MP0003300_gastrointestinal_ulcer0.19451555
72MP0005666_abnormal_adipose_tissue0.18290230
73MP0000432_abnormal_head_morphology0.17704262
74MP0003638_abnormal_response/metabolism_0.16573277
75MP0001879_abnormal_lymphatic_vessel0.15996037
76MP0004742_abnormal_vestibular_system0.15715152
77MP0003935_abnormal_craniofacial_develop0.15550605
78MP0005375_adipose_tissue_phenotype0.15507969
79MP0003448_altered_tumor_morphology0.14900427
80MP0000751_myopathy0.14564751
81MP0000604_amyloidosis0.14476412
82MP0004858_abnormal_nervous_system0.14034827
83MP0000516_abnormal_urinary_system0.13418783
84MP0005367_renal/urinary_system_phenotyp0.13418783
85MP0003011_delayed_dark_adaptation0.11687626
86MP0003075_altered_response_to0.11103282
87MP0005076_abnormal_cell_differentiation0.10721476
88MP0000733_abnormal_muscle_development0.10120421
89MP0002233_abnormal_nose_morphology0.09345293
90MP0003045_fibrosis0.09034043
91MP0002166_altered_tumor_susceptibility0.08911821
92MP0002006_tumorigenesis0.08772420
93MP0009379_abnormal_foot_pigmentation0.08504586
94MP0006138_congestive_heart_failure0.08078290
95MP0009384_cardiac_valve_regurgitation0.07788742
96MP0000750_abnormal_muscle_regeneration0.07766871
97MP0000013_abnormal_adipose_tissue0.07539539
98MP0005193_abnormal_anterior_eye0.07217934
99MP0001958_emphysema0.06234062
100MP0008569_lethality_at_weaning0.06209312

Predicted human phenotypes

RankGene SetZ-score
1Pili torti (HP:0003777)8.76151043
2Nail dystrophy (HP:0008404)7.52063975
3Abnormality of nail color (HP:0100643)5.81183266
4Abnormal hair laboratory examination (HP:0003328)5.53549260
5Fragile nails (HP:0001808)5.52380754
6Fine hair (HP:0002213)5.42583991
7Alopecia of scalp (HP:0002293)4.66285327
8Palmoplantar hyperkeratosis (HP:0000972)4.61312611
9Onycholysis (HP:0001806)4.59903428
10Palmar hyperkeratosis (HP:0010765)4.33690297
11Increased IgE level (HP:0003212)4.33068490
12Plantar hyperkeratosis (HP:0007556)4.21022855
13Thick nail (HP:0001805)4.14887292
14Right ventricular cardiomyopathy (HP:0011663)4.07259001
15Follicular hyperkeratosis (HP:0007502)3.88853401
16Sparse eyelashes (HP:0000653)3.45179796
17Erythema (HP:0010783)3.39508616
18Abnormality of the frontal sinuses (HP:0002687)3.19987865
19Oral leukoplakia (HP:0002745)3.15847127
20Amelogenesis imperfecta (HP:0000705)3.12146893
21Parakeratosis (HP:0001036)3.03096213
22Milia (HP:0001056)3.01400804
23Erythroderma (HP:0001019)2.92630731
24Curly hair (HP:0002212)2.70044017
25Intention tremor (HP:0002080)2.57668217
26Ridged nail (HP:0001807)2.56201430
27Neck muscle weakness (HP:0000467)2.52578268
28Congenital, generalized hypertrichosis (HP:0004540)2.51560596
29Aplasia cutis congenita (HP:0001057)2.49548552
30Congenital ichthyosiform erythroderma (HP:0007431)2.47030948
31Dry hair (HP:0011359)2.42588422
32Torticollis (HP:0000473)2.30731799
33Natal tooth (HP:0000695)2.27402908
34Abnormal blistering of the skin (HP:0008066)2.24177873
35Advanced eruption of teeth (HP:0006288)2.20063614
36Corneal erosion (HP:0200020)2.07545199
37Hypohidrosis (HP:0000966)2.06515528
38Hypotrichosis (HP:0001006)15.2237789
39Slow-growing hair (HP:0002217)11.5224010
40Abnormality of hair growth rate (HP:0011363)11.5224010
41Woolly hair (HP:0002224)11.0236382
42Brittle hair (HP:0002299)10.7582272
43Ventricular tachycardia (HP:0004756)1.97216016
44Palmoplantar keratoderma (HP:0000982)1.96613394
45Craniofacial dystonia (HP:0012179)1.95406459
46Concave nail (HP:0001598)1.89154304
47Difficulty walking (HP:0002355)1.89026635
48Pruritus (HP:0000989)1.85839324
49Abnormality of the pupil (HP:0000615)1.84151470
50Abnormality of dental color (HP:0011073)1.81843549
51Abnormality of the parietal bone (HP:0002696)1.80721987
52Abnormality of permanent molar morphology (HP:0011071)1.80642212
53Abnormality of the dental root (HP:0006486)1.80642212
54Taurodontia (HP:0000679)1.80642212
55Focal dystonia (HP:0004373)1.78745114
56Abnormality of molar morphology (HP:0011070)1.76890703
57Abnormality of molar (HP:0011077)1.76890703
58Widely patent fontanelles and sutures (HP:0004492)1.74622389
59Hyporeflexia of lower limbs (HP:0002600)1.71582452
60Ventricular fibrillation (HP:0001663)1.70668496
61Absent eyelashes (HP:0000561)1.64612752
62Recurrent corneal erosions (HP:0000495)1.62483327
63Conjunctival hamartoma (HP:0100780)1.60056196
64Abnormality of the dental pulp (HP:0006479)1.59208999
65Fatigable weakness (HP:0003473)1.52100233
66Abnormality of the neuromuscular junction (HP:0003398)1.52100233
67Sudden death (HP:0001699)1.51064782
68Blepharitis (HP:0000498)1.50273746
69Unilateral renal agenesis (HP:0000122)1.50202217
70Amniotic constriction ring (HP:0009775)1.49311403
71Abnormality of placental membranes (HP:0011409)1.49311403
72Abnormality of the aortic arch (HP:0012303)1.47161164
73Round ear (HP:0100830)1.46869186
74Acanthosis nigricans (HP:0000956)1.46452858
75Heterogeneous (HP:0001425)1.46285260
76Distal lower limb muscle weakness (HP:0009053)1.43124634
77Lip pit (HP:0100267)1.41890627
78Achilles tendon contracture (HP:0001771)1.38277100
79Keratoconjunctivitis sicca (HP:0001097)1.37727524
80Carious teeth (HP:0000670)1.33281565
81Craniofacial hyperostosis (HP:0004493)1.33242651
82Autoamputation (HP:0001218)1.32731905
83Gangrene (HP:0100758)1.31710695
84Abnormality of the Achilles tendon (HP:0005109)1.30268634
85Ectropion (HP:0000656)1.30211390
86Type 1 muscle fiber predominance (HP:0003803)1.26615536
87Variable expressivity (HP:0003828)1.25575954
88Hypergammaglobulinemia (HP:0010702)1.25337228
89Anonychia (HP:0001798)1.23250982
90Abnormality of the fingernails (HP:0001231)1.21989208
91Keratoconjunctivitis (HP:0001096)1.20996581
92Neonatal onset (HP:0003623)1.19921329
93Widely spaced teeth (HP:0000687)1.18270162
94Increased connective tissue (HP:0009025)1.17236189
95Selective tooth agenesis (HP:0001592)1.16829368
96Distal arthrogryposis (HP:0005684)1.14743543
97Lack of skin elasticity (HP:0100679)1.14620047
98Sparse scalp hair (HP:0002209)1.11860519
99Bronchomalacia (HP:0002780)1.11455068
100Wide cranial sutures (HP:0010537)1.10250921

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.40057013
2MAPKAPK34.24224758
3FER3.93195839
4ERN13.87407941
5MAP3K63.49965454
6EPHB23.16121925
7TAOK13.04561716
8MAP3K32.84607417
9TRIB32.69822292
10LATS12.39897641
11MAP3K22.38882940
12PIK3CG2.13947089
13MAP3K112.08031343
14RPS6KB22.05160001
15TTN2.01649124
16MAP2K61.80048139
17EEF2K1.74986799
18LATS21.63599865
19EPHB11.60757941
20NME11.57417741
21BCR1.34015192
22MAP3K11.29942284
23FGFR21.28638631
24KSR21.25345172
25MAP2K31.24549068
26RIPK11.20857389
27FGFR41.19327687
28BMX1.17376414
29PKN21.15280530
30CDK61.14585661
31MST1R1.14412573
32BLK1.13447153
33PBK1.07103006
34MAPKAPK21.06803990
35LRRK21.06315771
36FGFR11.03190165
37MAP3K70.99854489
38FGFR30.96965156
39PTK60.96904219
40PDGFRA0.96399680
41MAP2K40.85819153
42MAP3K90.84810851
43SIK10.83943111
44RPS6KA40.80850833
45MAP2K10.80360557
46PIM20.78063835
47STK380.77622604
48PTK20.76607923
49CDK190.73021742
50OBSCN0.72686251
51STK38L0.71853510
52DYRK1B0.71412742
53PRKD10.70870850
54TESK10.70827550
55PAK40.69802157
56PAK30.67897389
57DDR20.65613384
58MET0.64312569
59NEK10.57432524
60PRKCI0.57295976
61ERBB40.56957110
62MAP3K50.55912801
63TRPM70.53623366
64TGFBR10.52717672
65NTRK20.52468663
66TYRO30.51606329
67PRKCH0.51208928
68MAP3K100.50765070
69RET0.49596567
70PAK60.49072569
71ALK0.47414994
72MAPK120.46485993
73ERBB20.44750517
74PHKG20.44245669
75PHKG10.44245669
76PAK20.44041627
77RPS6KA10.43163599
78JAK10.42495827
79GSK3A0.42329003
80MAP2K20.41536490
81CSNK1E0.39898038
82MST40.39863968
83ERBB30.38054217
84ILK0.37287099
85EPHA30.37255665
86TYK20.36433107
87LIMK10.36078254
88JAK20.35408535
89GRK60.30101649
90MAP3K80.29334013
91FYN0.27235034
92CSNK1A10.24308486
93ROCK20.23600259
94SRC0.23484582
95PRKACA0.22041225
96PRKACG0.21682587
97CLK10.21676555
98HCK0.21675475
99CSNK1D0.21355172
100STK110.20781207

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.85349375
2Linoleic acid metabolism_Homo sapiens_hsa005914.82004357
3Fat digestion and absorption_Homo sapiens_hsa049753.13968781
4Fatty acid elongation_Homo sapiens_hsa000622.79481561
5Ether lipid metabolism_Homo sapiens_hsa005652.53799887
6Basal cell carcinoma_Homo sapiens_hsa052172.20489481
7Phenylalanine metabolism_Homo sapiens_hsa003601.86052484
8Arachidonic acid metabolism_Homo sapiens_hsa005901.85153184
9Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.77196286
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.76844792
11VEGF signaling pathway_Homo sapiens_hsa043701.73253314
12Melanogenesis_Homo sapiens_hsa049161.59517695
13Axon guidance_Homo sapiens_hsa043601.52759409
14Histidine metabolism_Homo sapiens_hsa003401.40566489
15Hedgehog signaling pathway_Homo sapiens_hsa043401.37778807
16Bladder cancer_Homo sapiens_hsa052191.35967911
17Glioma_Homo sapiens_hsa052141.33578657
18Vascular smooth muscle contraction_Homo sapiens_hsa042701.31377035
19Caffeine metabolism_Homo sapiens_hsa002321.31230646
20Thyroid cancer_Homo sapiens_hsa052161.30899163
21Proteoglycans in cancer_Homo sapiens_hsa052051.26925072
22GnRH signaling pathway_Homo sapiens_hsa049121.24024314
23Hippo signaling pathway_Homo sapiens_hsa043901.22604111
24Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16497500
25Tight junction_Homo sapiens_hsa045301.15739563
26Acute myeloid leukemia_Homo sapiens_hsa052211.14066776
27Pancreatic secretion_Homo sapiens_hsa049721.11191077
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.06867393
29Nitrogen metabolism_Homo sapiens_hsa009101.05811990
30Mineral absorption_Homo sapiens_hsa049781.05389129
31Long-term potentiation_Homo sapiens_hsa047201.04198606
32PPAR signaling pathway_Homo sapiens_hsa033201.04048012
33Dorso-ventral axis formation_Homo sapiens_hsa043201.02142992
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96661219
35Glycerophospholipid metabolism_Homo sapiens_hsa005640.92432226
36Adherens junction_Homo sapiens_hsa045200.91237039
37Tyrosine metabolism_Homo sapiens_hsa003500.90584624
38Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.90344011
39Steroid biosynthesis_Homo sapiens_hsa001000.89515401
40Pertussis_Homo sapiens_hsa051330.88315369
41ECM-receptor interaction_Homo sapiens_hsa045120.86876132
42Non-small cell lung cancer_Homo sapiens_hsa052230.86347521
43Endometrial cancer_Homo sapiens_hsa052130.84376216
44Long-term depression_Homo sapiens_hsa047300.83635513
45beta-Alanine metabolism_Homo sapiens_hsa004100.82317553
46Estrogen signaling pathway_Homo sapiens_hsa049150.81816664
47Ras signaling pathway_Homo sapiens_hsa040140.81161113
48Leukocyte transendothelial migration_Homo sapiens_hsa046700.79890869
49Wnt signaling pathway_Homo sapiens_hsa043100.76150979
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.76111299
51Staphylococcus aureus infection_Homo sapiens_hsa051500.74537126
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74483734
53Amoebiasis_Homo sapiens_hsa051460.73408740
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.72580952
55Cyanoamino acid metabolism_Homo sapiens_hsa004600.71214674
56Gastric acid secretion_Homo sapiens_hsa049710.69893190
57Renin secretion_Homo sapiens_hsa049240.68139972
58Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67098361
59Sphingolipid signaling pathway_Homo sapiens_hsa040710.64353040
60Fatty acid metabolism_Homo sapiens_hsa012120.64342055
61Phototransduction_Homo sapiens_hsa047440.61874507
62Insulin resistance_Homo sapiens_hsa049310.60049839
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59156791
64MicroRNAs in cancer_Homo sapiens_hsa052060.58789394
65Hepatitis C_Homo sapiens_hsa051600.55745012
66Gap junction_Homo sapiens_hsa045400.55218990
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.55094932
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54316388
69Salmonella infection_Homo sapiens_hsa051320.53531482
70Rap1 signaling pathway_Homo sapiens_hsa040150.53330916
71Oxytocin signaling pathway_Homo sapiens_hsa049210.51344608
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.51018393
73Butanoate metabolism_Homo sapiens_hsa006500.50379191
74Fatty acid degradation_Homo sapiens_hsa000710.49616993
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49097566
76Renal cell carcinoma_Homo sapiens_hsa052110.48359287
77Salivary secretion_Homo sapiens_hsa049700.47494658
78Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47180174
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46818572
80Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46813140
81Focal adhesion_Homo sapiens_hsa045100.46758812
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46400220
83Platelet activation_Homo sapiens_hsa046110.46051366
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44515469
85ErbB signaling pathway_Homo sapiens_hsa040120.44406880
86Chemical carcinogenesis_Homo sapiens_hsa052040.44139503
87Prion diseases_Homo sapiens_hsa050200.42529474
88Protein digestion and absorption_Homo sapiens_hsa049740.41141290
89TGF-beta signaling pathway_Homo sapiens_hsa043500.40984668
90Olfactory transduction_Homo sapiens_hsa047400.38550025
91Tuberculosis_Homo sapiens_hsa051520.37722883
92Chronic myeloid leukemia_Homo sapiens_hsa052200.37391994
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37370209
94p53 signaling pathway_Homo sapiens_hsa041150.36230429
95Insulin signaling pathway_Homo sapiens_hsa049100.36021483
96Arginine biosynthesis_Homo sapiens_hsa002200.34997314
97Prolactin signaling pathway_Homo sapiens_hsa049170.34434420
98Primary bile acid biosynthesis_Homo sapiens_hsa001200.34187340
99Toxoplasmosis_Homo sapiens_hsa051450.33372514
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.30880699

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