KRT8P46

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.15701836
2response to peptidoglycan (GO:0032494)5.10145988
3cellular extravasation (GO:0045123)4.76041583
4positive regulation by symbiont of host defense response (GO:0052509)4.73851683
5modulation by symbiont of host defense response (GO:0052031)4.73851683
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.73851683
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.73851683
8positive regulation by organism of defense response of other organism involved in symbiotic interact4.73851683
9modulation by symbiont of host immune response (GO:0052553)4.73851683
10response to muramyl dipeptide (GO:0032495)4.46754352
11positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.27444132
12detection of molecule of bacterial origin (GO:0032490)4.26110699
13neutrophil activation involved in immune response (GO:0002283)4.16926941
14macrophage activation involved in immune response (GO:0002281)4.07956977
15regulation of B cell receptor signaling pathway (GO:0050855)4.07517260
16negative regulation of interleukin-12 production (GO:0032695)3.84288441
17macrophage activation (GO:0042116)3.77444601
18positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.69026037
19negative regulation of erythrocyte differentiation (GO:0045647)3.66053583
20B cell receptor signaling pathway (GO:0050853)3.62633034
21regulation of gamma-delta T cell activation (GO:0046643)3.56912474
22neutrophil mediated immunity (GO:0002446)3.54566829
23detection of other organism (GO:0098543)3.54121923
24germinal center formation (GO:0002467)3.43476410
25regulation of mast cell degranulation (GO:0043304)3.42282578
26regulation of interferon-beta biosynthetic process (GO:0045357)3.39587253
27regulation of leukocyte degranulation (GO:0043300)3.39164254
28response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.37466104
29response to host immune response (GO:0052572)3.37466104
30histone H3-K36 demethylation (GO:0070544)3.37182386
31detection of external biotic stimulus (GO:0098581)3.36845035
32lipopolysaccharide-mediated signaling pathway (GO:0031663)3.31701012
33microglial cell activation (GO:0001774)3.31355952
34detection of biotic stimulus (GO:0009595)3.30630503
35embryonic process involved in female pregnancy (GO:0060136)3.30002348
36regulation of myeloid leukocyte mediated immunity (GO:0002886)3.26141626
37hepatocyte apoptotic process (GO:0097284)3.24688157
38regulation of gamma-delta T cell differentiation (GO:0045586)3.23429572
39response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.22677422
40response to host (GO:0075136)3.22677422
41response to host defenses (GO:0052200)3.22677422
42negative regulation of cell killing (GO:0031342)3.22471772
43negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.22471772
44antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.20296150
45regulation of mast cell activation involved in immune response (GO:0033006)3.16547836
46respiratory burst (GO:0045730)3.13498003
47myeloid cell activation involved in immune response (GO:0002275)3.11522583
48pinocytosis (GO:0006907)3.04890556
49positive regulation of B cell differentiation (GO:0045579)3.01913960
50positive regulation of mast cell activation (GO:0033005)3.01266554
51regulation of mast cell activation (GO:0033003)2.96138898
52regulation of necroptotic process (GO:0060544)2.96049054
53positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.95753911
54cellular response to ethanol (GO:0071361)2.94577259
55production of molecular mediator involved in inflammatory response (GO:0002532)2.92723792
56negative regulation of toll-like receptor signaling pathway (GO:0034122)2.92664700
57regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.91771913
58negative regulation of interleukin-17 production (GO:0032700)2.91291884
59positive thymic T cell selection (GO:0045059)2.90771174
60myeloid leukocyte mediated immunity (GO:0002444)2.90683300
61detection of bacterium (GO:0016045)2.89129252
62regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.86625496
63labyrinthine layer development (GO:0060711)2.85012823
64oligosaccharide catabolic process (GO:0009313)2.84809429
65antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.84215095
66neutrophil activation (GO:0042119)2.82726516
67antigen processing and presentation of endogenous antigen (GO:0019883)2.82519583
68positive regulation of leukocyte degranulation (GO:0043302)2.78702212
69antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.74841033
70T-helper 1 type immune response (GO:0042088)2.74650025
71negative regulation of interleukin-8 production (GO:0032717)2.73969646
72regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.72871570
73granulocyte activation (GO:0036230)2.72244970
74response to laminar fluid shear stress (GO:0034616)2.66180557
75regulation of B cell differentiation (GO:0045577)2.63246077
76positive regulation of interferon-alpha production (GO:0032727)2.62812807
77negative regulation of T cell mediated immunity (GO:0002710)2.62519168
78regulation of interleukin-12 biosynthetic process (GO:0045075)2.62499369
79positive regulation of mast cell degranulation (GO:0043306)2.62217012
80positive regulation of mast cell activation involved in immune response (GO:0033008)2.62217012
81energy homeostasis (GO:0097009)2.62026300
82regulation of macrophage cytokine production (GO:0010935)2.61589724
83regulation of interleukin-8 biosynthetic process (GO:0045414)2.59452889
84glycosphingolipid catabolic process (GO:0046479)2.59401116
85dosage compensation (GO:0007549)2.59101404
86regulation of regulated secretory pathway (GO:1903305)2.58338002
87mannose metabolic process (GO:0006013)2.57485792
88mature B cell differentiation involved in immune response (GO:0002313)2.57026537
89regulation of toll-like receptor signaling pathway (GO:0034121)2.55938613
90glycolipid catabolic process (GO:0019377)2.54997514
91neutrophil chemotaxis (GO:0030593)2.54521783
92mature B cell differentiation (GO:0002335)2.53063877
93immunoglobulin mediated immune response (GO:0016064)2.52861894
94positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.51571737
95leukocyte aggregation (GO:0070486)2.49958631
96positive regulation of toll-like receptor signaling pathway (GO:0034123)2.48786425
97B cell homeostasis (GO:0001782)2.48270790
98neutrophil migration (GO:1990266)2.47124948
99negative regulation of necroptotic process (GO:0060546)2.46097456
100positive T cell selection (GO:0043368)2.45257630

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.42389889
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.08225543
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.37224470
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.31539989
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.25969361
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.17890621
7MYB_21317192_ChIP-Seq_ERMYB_Mouse3.11553499
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.05855711
9VDR_21846776_ChIP-Seq_THP-1_Human3.04980173
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.04427871
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.96957688
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.86911563
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.75976859
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.74516894
15MYC_22102868_ChIP-Seq_BL_Human2.69116433
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.68114684
17GATA1_22025678_ChIP-Seq_K562_Human2.67917492
18VDR_24763502_ChIP-Seq_THP-1_Human2.65570120
19Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.61378519
20SCL_19346495_ChIP-Seq_HPC-7_Human2.60754850
21BRD4_27068464_Chip-Seq_AML-cells_Mouse2.43458826
22SPI1_23547873_ChIP-Seq_NB4_Human2.36309886
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.30415616
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.25755434
25RUNX_20019798_ChIP-Seq_JUKART_Human2.22964697
26SPI1_23127762_ChIP-Seq_K562_Human2.15680027
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.15176958
28MYB_26560356_Chip-Seq_TH2_Human2.06484229
29TCF7_22412390_ChIP-Seq_EML_Mouse2.04023619
30STAT4_19710469_ChIP-ChIP_TH1__Mouse1.98984807
31FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.97397727
32MYB_26560356_Chip-Seq_TH1_Human1.93978543
33MAF_26560356_Chip-Seq_TH1_Human1.91811155
34VDR_24787735_ChIP-Seq_THP-1_Human1.85739973
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.82742159
36TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.82491930
37BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.82087092
38KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.80254641
39IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.79970342
40RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.77031118
41E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.75398564
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.71619024
43UTX_26944678_Chip-Seq_JUKART_Human1.66392918
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.65422767
45IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.64699070
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.63793071
47KDM2B_26808549_Chip-Seq_DND41_Human1.59044385
48KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.56735750
49PU_27001747_Chip-Seq_BMDM_Mouse1.53282889
50ESR1_20079471_ChIP-ChIP_T-47D_Human1.52150618
51NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.46544151
52GATA2_22383799_ChIP-Seq_G1ME_Mouse1.46277339
53RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.43972452
54GATA1_19941827_ChIP-Seq_MEL_Mouse1.40573614
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34930035
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.30643953
57TFEB_21752829_ChIP-Seq_HELA_Human1.29676075
58MAF_26560356_Chip-Seq_TH2_Human1.25273076
59ELK3_25401928_ChIP-Seq_HUVEC_Human1.25119441
60GATA3_27048872_Chip-Seq_THYMUS_Human1.24892415
61GATA2_19941826_ChIP-Seq_K562_Human1.22571526
62GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21280431
63PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20426509
64GATA2_21666600_ChIP-Seq_HMVEC_Human1.19696859
65SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.18378388
66SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.18378388
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16569507
68GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16183893
69KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16110273
70KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15854650
71MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.13365539
72SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12814406
73TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11644861
74CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10769413
75GATA1_19941826_ChIP-Seq_K562_Human1.07955639
76KDM2B_26808549_Chip-Seq_JURKAT_Human1.06604951
77PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04693526
78PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02795219
79SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02775371
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99305173
81TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.98960305
82CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98295995
83ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95113899
84ESR2_21235772_ChIP-Seq_MCF-7_Human0.95006772
85GATA3_26560356_Chip-Seq_TH2_Human0.93800413
86NCOR1_26117541_ChIP-Seq_K562_Human0.93442071
87LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.93330627
88FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91840040
89FOXO3_23340844_ChIP-Seq_DLD1_Human0.91281413
90STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89778336
91STAT6_21828071_ChIP-Seq_BEAS2B_Human0.88948024
92TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88775017
93CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88330107
94RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88164905
95TP63_17297297_ChIP-ChIP_HaCaT_Human0.87049489
96CLOCK_20551151_ChIP-Seq_293T_Human0.87044437
97CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86354068
98DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.81889688
99CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81512742
100FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.81438848

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.27763267
2MP0003303_peritoneal_inflammation3.26163249
3MP0001835_abnormal_antigen_presentation3.23525805
4MP0003436_decreased_susceptibility_to2.77413514
5MP0003724_increased_susceptibility_to2.52483483
6MP0002419_abnormal_innate_immunity2.44643159
7MP0003828_pulmonary_edema2.40172304
8MP0005058_abnormal_lysosome_morphology2.16540531
9MP0000685_abnormal_immune_system2.13768299
10MP0003300_gastrointestinal_ulcer2.10477576
11MP0003172_abnormal_lysosome_physiology2.07415534
12MP0001800_abnormal_humoral_immune2.05257076
13MP0005000_abnormal_immune_tolerance2.05254315
14MP0008260_abnormal_autophagy2.02614746
15MP0002452_abnormal_antigen_presenting2.00247335
16MP0005464_abnormal_platelet_physiology1.99497100
17MP0004947_skin_inflammation1.97285591
18MP0005025_abnormal_response_to1.94605209
19MP0010234_abnormal_vibrissa_follicle1.93622090
20MP0009278_abnormal_bone_marrow1.85833717
21MP0002420_abnormal_adaptive_immunity1.85790517
22MP0002723_abnormal_immune_serum1.84803985
23MP0008057_abnormal_DNA_replication1.84712337
24MP0010352_gastrointestinal_tract_polyps1.84663175
25MP0001819_abnormal_immune_cell1.84414991
26MP0009840_abnormal_foam_cell1.83130942
27MP0003763_abnormal_thymus_physiology1.82491229
28MP0002166_altered_tumor_susceptibility1.81983503
29MP0000569_abnormal_digit_pigmentation1.80954879
30MP0005076_abnormal_cell_differentiation1.80587522
31MP0003191_abnormal_cellular_cholesterol1.75595752
32MP0009785_altered_susceptibility_to1.73980868
33MP0001790_abnormal_immune_system1.66662936
34MP0005387_immune_system_phenotype1.66662936
35MP0002009_preneoplasia1.66271569
36MP0002396_abnormal_hematopoietic_system1.66115832
37MP0002148_abnormal_hypersensitivity_rea1.62420343
38MP0002405_respiratory_system_inflammati1.51638888
39MP0002398_abnormal_bone_marrow1.51369028
40MP0006082_CNS_inflammation1.50561913
41MP0001853_heart_inflammation1.49688455
42MP0002998_abnormal_bone_remodeling1.48634853
43MP0000716_abnormal_immune_system1.48395080
44MP0010155_abnormal_intestine_physiology1.46084652
45MP0000465_gastrointestinal_hemorrhage1.43993460
46MP0003806_abnormal_nucleotide_metabolis1.43383606
47MP0003221_abnormal_cardiomyocyte_apopto1.43335856
48MP0003656_abnormal_erythrocyte_physiolo1.41716963
49MP0003091_abnormal_cell_migration1.41619001
50MP0002877_abnormal_melanocyte_morpholog1.41558512
51MP0004808_abnormal_hematopoietic_stem1.41180527
52MP0005671_abnormal_response_to1.40406710
53MP0005397_hematopoietic_system_phenotyp1.40315152
54MP0001545_abnormal_hematopoietic_system1.40315152
55MP0001845_abnormal_inflammatory_respons1.38881094
56MP0002722_abnormal_immune_system1.37513083
57MP0004484_altered_response_of1.35401189
58MP0002132_abnormal_respiratory_system1.34873176
59MP0004264_abnormal_extraembryonic_tissu1.30734753
60MP0000689_abnormal_spleen_morphology1.29900000
61MP0002006_tumorigenesis1.29100054
62MP0001533_abnormal_skeleton_physiology1.28799244
63MP0002429_abnormal_blood_cell1.22703335
64MP0009764_decreased_sensitivity_to1.20452057
65MP0004510_myositis1.13623065
66MP0010678_abnormal_skin_adnexa1.10317506
67MP0000604_amyloidosis1.10008383
68MP0000703_abnormal_thymus_morphology1.09882935
69MP0002332_abnormal_exercise_endurance1.09737466
70MP0000015_abnormal_ear_pigmentation1.08140293
71MP0000858_altered_metastatic_potential1.07302680
72MP0004036_abnormal_muscle_relaxation1.06427930
73MP0003866_abnormal_defecation1.05251271
74MP0004233_abnormal_muscle_weight1.04912525
75MP0004381_abnormal_hair_follicle1.03241830
76MP0008469_abnormal_protein_level1.01228894
77MP0003453_abnormal_keratinocyte_physiol1.00094966
78MP0005166_decreased_susceptibility_to0.97763014
79MP0003183_abnormal_peptide_metabolism0.97098227
80MP0005310_abnormal_salivary_gland0.96885821
81MP0004084_abnormal_cardiac_muscle0.94703868
82MP0000343_altered_response_to0.94025270
83MP0004883_abnormal_blood_vessel0.91449493
84MP0008004_abnormal_stomach_pH0.89846030
85MP0010630_abnormal_cardiac_muscle0.87774837
86MP0000383_abnormal_hair_follicle0.87656761
87MP0003448_altered_tumor_morphology0.85823587
88MP0000749_muscle_degeneration0.84393937
89MP0004130_abnormal_muscle_cell0.84376802
90MP0003566_abnormal_cell_adhesion0.82821896
91MP0005083_abnormal_biliary_tract0.82576112
92MP0004185_abnormal_adipocyte_glucose0.82453305
93MP0003075_altered_response_to0.82040707
94MP0001851_eye_inflammation0.81841820
95MP0009115_abnormal_fat_cell0.80287740
96MP0005164_abnormal_response_to0.79827916
97MP0000490_abnormal_crypts_of0.79093425
98MP0001849_ear_inflammation0.77939635
99MP0003705_abnormal_hypodermis_morpholog0.77003699
100MP0004087_abnormal_muscle_fiber0.74111522

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)4.74784313
2Eczematoid dermatitis (HP:0000976)4.62632980
3Recurrent abscess formation (HP:0002722)4.40230177
4Abnormality of macrophages (HP:0004311)3.89562943
5Abnormality of glycolipid metabolism (HP:0010969)3.61838521
6Abnormality of liposaccharide metabolism (HP:0010968)3.61838521
7Abnormality of glycosphingolipid metabolism (HP:0004343)3.61838521
8Mediastinal lymphadenopathy (HP:0100721)3.48686297
9Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.46911851
10Colitis (HP:0002583)3.41595743
11Recurrent fungal infections (HP:0002841)3.22155816
12Elevated erythrocyte sedimentation rate (HP:0003565)3.11248074
13Cellulitis (HP:0100658)3.05750450
14Recurrent viral infections (HP:0004429)3.05726586
15Myositis (HP:0100614)3.05291725
16Recurrent gram-negative bacterial infections (HP:0005420)2.99953342
17Gingivitis (HP:0000230)2.96934476
18Orchitis (HP:0100796)2.88182271
19Recurrent skin infections (HP:0001581)2.85223491
20Optic neuritis (HP:0100653)2.82596417
21Retrobulbar optic neuritis (HP:0100654)2.82596417
22Inflammation of the large intestine (HP:0002037)2.81990300
23Centrally nucleated skeletal muscle fibers (HP:0003687)2.81605516
24Myocardial infarction (HP:0001658)2.78344354
25T lymphocytopenia (HP:0005403)2.78142958
26Spontaneous hematomas (HP:0007420)2.69314507
27Gastrointestinal infarctions (HP:0005244)2.68928086
28Amyloidosis (HP:0011034)2.67956884
29Subacute progressive viral hepatitis (HP:0006572)2.66085322
30Gastrointestinal inflammation (HP:0004386)2.61815167
31Stomatitis (HP:0010280)2.56661119
32Chronic mucocutaneous candidiasis (HP:0002728)2.54829184
33Recurrent cutaneous fungal infections (HP:0011370)2.54829184
34Abnormality of T cell number (HP:0011839)2.53159780
35Increased cerebral lipofuscin (HP:0011813)2.53031085
36Meningitis (HP:0001287)2.51404483
37Granulocytopenia (HP:0001913)2.50211844
38Arterial thrombosis (HP:0004420)2.48816348
39Viral hepatitis (HP:0006562)2.48733670
40Autoimmune thrombocytopenia (HP:0001973)2.47959840
41Loss of speech (HP:0002371)2.45440249
42Chest pain (HP:0100749)2.39884672
43Chronic obstructive pulmonary disease (HP:0006510)2.39877680
44Obstructive lung disease (HP:0006536)2.39877680
45Syringomyelia (HP:0003396)2.37816087
46Spinal cord lesions (HP:0100561)2.37816087
47Dysmetric saccades (HP:0000641)2.34226462
48Leukocytosis (HP:0001974)2.33910395
49Vasculitis (HP:0002633)2.30939713
50Eosinophilia (HP:0001880)2.30261510
51Gingival bleeding (HP:0000225)2.27595104
52Increased connective tissue (HP:0009025)2.26628094
53Osteomyelitis (HP:0002754)2.26123462
54Fatigue (HP:0012378)2.24153015
55Abnormality of the fingertips (HP:0001211)2.19381253
56Thrombocytosis (HP:0001894)2.14585474
57Polycythemia (HP:0001901)2.14278058
58Distal lower limb amyotrophy (HP:0008944)2.14218807
59Keratoconjunctivitis sicca (HP:0001097)2.14213858
60Urticaria (HP:0001025)2.12523438
61Abnormality of the columella (HP:0009929)2.09818573
62Abnormal delayed hypersensitivity skin test (HP:0002963)2.08793404
63Hyporeflexia of lower limbs (HP:0002600)2.08025919
64Abnormality of the endocardium (HP:0004306)2.07830166
65Epistaxis (HP:0000421)2.07725727
66Interstitial pulmonary disease (HP:0006530)2.07086494
67Difficulty running (HP:0009046)2.02407906
68Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.99662791
69Slow saccadic eye movements (HP:0000514)1.98633995
70Vacuolated lymphocytes (HP:0001922)1.97463323
71Autoimmune hemolytic anemia (HP:0001890)1.97330962
72Thoracic kyphosis (HP:0002942)1.97140135
73Dysostosis multiplex (HP:0000943)1.96539747
74Abnormality of the vasculature of the conjunctiva (HP:0008054)1.93402484
75Bulbar palsy (HP:0001283)1.91245990
76Hemoptysis (HP:0002105)1.90915034
77Increased neuronal autofluorescent lipopigment (HP:0002074)1.90199491
78Periodontitis (HP:0000704)1.88357302
79Pustule (HP:0200039)1.88249110
80Micronodular cirrhosis (HP:0001413)1.87718102
81Hematochezia (HP:0002573)1.85377517
82Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.83247222
83Amaurosis fugax (HP:0100576)1.83170493
84Increased IgE level (HP:0003212)1.81081886
85Exercise-induced myalgia (HP:0003738)1.79460634
86Malnutrition (HP:0004395)1.79006667
87Encephalitis (HP:0002383)1.77169435
88Keratoconjunctivitis (HP:0001096)1.77040053
89Abnormality of T cells (HP:0002843)1.77029668
90Prolonged bleeding time (HP:0003010)1.76399146
91Acute myeloid leukemia (HP:0004808)1.76017559
92Thick nail (HP:0001805)1.75960429
93Abnormality of the thoracic spine (HP:0100711)1.75065699
94IgM deficiency (HP:0002850)1.74942085
95Polyneuropathy (HP:0001271)1.74538726
96Osteolytic defects of the phalanges of the hand (HP:0009771)1.74457885
97Osteolytic defects of the hand bones (HP:0009699)1.74457885
98Resting tremor (HP:0002322)1.73705510
99Thoracolumbar scoliosis (HP:0002944)1.72762266
100EMG: myopathic abnormalities (HP:0003458)1.72650650

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK3.03167278
2MAP2K32.98734468
3PRPF4B2.90833658
4MAP3K142.82063855
5IRAK32.73141645
6CDK122.34336810
7RIPK42.34187203
8BMPR21.92624606
9MAP4K11.89391464
10TAOK31.87666751
11ZAP701.87301201
12IKBKE1.86947769
13IRAK41.86518492
14MAP3K131.82550498
15TTN1.81908071
16TYK21.70663959
17TBK11.69648054
18CSK1.69082016
19BTK1.68006467
20SCYL21.66963826
21MAP3K61.64723424
22TRIB31.64167422
23MAP3K11.64091625
24IRAK21.57002257
25PIK3CG1.54530298
26GRK61.50651707
27MARK31.50227569
28OBSCN1.46543598
29EEF2K1.42979120
30PBK1.41617300
31FGR1.35301307
32FES1.30768161
33JAK31.30284027
34JAK11.29670509
35CDK61.21240217
36IKBKB1.20375220
37SYK1.20269275
38KSR21.13226260
39HCK1.12137967
40RET1.10807922
41ICK1.09642590
42ERN11.07376759
43SGK31.02566384
44TGFBR21.02337929
45RPS6KB21.01136997
46MAP3K101.00180270
47IRAK10.99988853
48TRPM70.99268627
49PKN20.98748602
50STK100.98175381
51MAP3K20.97583570
52MAP3K30.95483183
53MAP3K50.91910413
54STK40.90233935
55JAK20.88171382
56NEK90.87420922
57MARK20.86628954
58FGFR30.84748670
59LYN0.82823690
60CSF1R0.81986776
61MOS0.81816534
62MAPK70.80903877
63PDPK10.80726205
64SGK20.79712537
65TEC0.79166887
66KIT0.77204291
67LCK0.77100919
68PIM10.75393691
69PINK10.74163442
70CAMK1D0.73930692
71PDK10.73821327
72NEK60.72205052
73TXK0.71913710
74MATK0.70105207
75STK240.69350977
76CHUK0.68284716
77MTOR0.66449383
78MELK0.66406507
79MAP2K40.65093038
80BRD40.63624909
81RAF10.62612312
82CDK40.62115506
83MAPK120.61184225
84NME20.60959114
85PDK20.60353113
86ITK0.59170562
87SMG10.58999225
88RPS6KB10.58916742
89AKT30.54338747
90MAPK110.50636982
91LRRK20.50615635
92RPS6KL10.49128144
93RPS6KC10.49128144
94WNK10.47822092
95GRK70.47395711
96TAOK20.46100399
97CAMK1G0.42040731
98CDC42BPA0.39507612
99MAP3K80.36255361
100PRKCQ0.36123045

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046622.55228098
2Leishmaniasis_Homo sapiens_hsa051402.55035210
3Osteoclast differentiation_Homo sapiens_hsa043802.45331627
4Other glycan degradation_Homo sapiens_hsa005112.42324021
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.13513842
6Acute myeloid leukemia_Homo sapiens_hsa052211.94493607
7NF-kappa B signaling pathway_Homo sapiens_hsa040641.88166953
8Tuberculosis_Homo sapiens_hsa051521.87648154
9NOD-like receptor signaling pathway_Homo sapiens_hsa046211.85075548
10Non-small cell lung cancer_Homo sapiens_hsa052231.81912074
11Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.73220949
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.72741008
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.66409744
14Legionellosis_Homo sapiens_hsa051341.65900066
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.65467028
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.62760614
17Chronic myeloid leukemia_Homo sapiens_hsa052201.58490993
18T cell receptor signaling pathway_Homo sapiens_hsa046601.55551097
19Toxoplasmosis_Homo sapiens_hsa051451.55203740
20TNF signaling pathway_Homo sapiens_hsa046681.54820371
21Staphylococcus aureus infection_Homo sapiens_hsa051501.54731462
22Influenza A_Homo sapiens_hsa051641.54434159
23Systemic lupus erythematosus_Homo sapiens_hsa053221.46999561
24Measles_Homo sapiens_hsa051621.46893511
25Hepatitis B_Homo sapiens_hsa051611.39275975
26Malaria_Homo sapiens_hsa051441.38161933
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.36441211
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.36174187
29Pancreatic cancer_Homo sapiens_hsa052121.35750879
30Renal cell carcinoma_Homo sapiens_hsa052111.35433868
31Neurotrophin signaling pathway_Homo sapiens_hsa047221.27982691
32Platelet activation_Homo sapiens_hsa046111.25297795
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.25223119
34Endometrial cancer_Homo sapiens_hsa052131.20997320
35Apoptosis_Homo sapiens_hsa042101.20815483
36Lysosome_Homo sapiens_hsa041421.20496177
37Hepatitis C_Homo sapiens_hsa051601.19585223
38Viral carcinogenesis_Homo sapiens_hsa052031.19323206
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.16573049
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.15872010
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.14609328
42Hematopoietic cell lineage_Homo sapiens_hsa046401.13834719
43Herpes simplex infection_Homo sapiens_hsa051681.13697895
44HIF-1 signaling pathway_Homo sapiens_hsa040661.11901262
45Chemokine signaling pathway_Homo sapiens_hsa040621.11737087
46Graft-versus-host disease_Homo sapiens_hsa053321.05202234
47mTOR signaling pathway_Homo sapiens_hsa041501.05010852
48Shigellosis_Homo sapiens_hsa051311.01618461
49FoxO signaling pathway_Homo sapiens_hsa040680.99619320
50Prolactin signaling pathway_Homo sapiens_hsa049170.98968175
51Inositol phosphate metabolism_Homo sapiens_hsa005620.97802803
52VEGF signaling pathway_Homo sapiens_hsa043700.96351613
53Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94876887
54Salmonella infection_Homo sapiens_hsa051320.94171158
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93886178
56Allograft rejection_Homo sapiens_hsa053300.93779300
57Phagosome_Homo sapiens_hsa041450.91904286
58Pertussis_Homo sapiens_hsa051330.90207584
59Sphingolipid signaling pathway_Homo sapiens_hsa040710.89219636
60Prostate cancer_Homo sapiens_hsa052150.88035289
61ErbB signaling pathway_Homo sapiens_hsa040120.88000372
62Insulin resistance_Homo sapiens_hsa049310.86691372
63Dorso-ventral axis formation_Homo sapiens_hsa043200.85440308
64Asthma_Homo sapiens_hsa053100.84036797
65Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.83384868
66Antigen processing and presentation_Homo sapiens_hsa046120.83379428
67Viral myocarditis_Homo sapiens_hsa054160.83347529
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.82554200
69Bladder cancer_Homo sapiens_hsa052190.81706187
70Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81600994
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.81103186
72GnRH signaling pathway_Homo sapiens_hsa049120.80507760
73Thyroid cancer_Homo sapiens_hsa052160.80322454
74Autoimmune thyroid disease_Homo sapiens_hsa053200.77745447
75Rheumatoid arthritis_Homo sapiens_hsa053230.77063922
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76984294
77Amoebiasis_Homo sapiens_hsa051460.75375536
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75321652
79Choline metabolism in cancer_Homo sapiens_hsa052310.72715588
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.71647037
81Glioma_Homo sapiens_hsa052140.70799020
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70223685
83Small cell lung cancer_Homo sapiens_hsa052220.69866957
84Colorectal cancer_Homo sapiens_hsa052100.68359319
85HTLV-I infection_Homo sapiens_hsa051660.68302613
86Proteoglycans in cancer_Homo sapiens_hsa052050.65864300
87Primary immunodeficiency_Homo sapiens_hsa053400.65556820
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.62779435
89Epstein-Barr virus infection_Homo sapiens_hsa051690.62699758
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62165433
91Insulin signaling pathway_Homo sapiens_hsa049100.59055614
92Type II diabetes mellitus_Homo sapiens_hsa049300.58694540
93Alcoholism_Homo sapiens_hsa050340.58319671
94MicroRNAs in cancer_Homo sapiens_hsa052060.55013030
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54790661
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.54209874
97Notch signaling pathway_Homo sapiens_hsa043300.51931589
98Type I diabetes mellitus_Homo sapiens_hsa049400.51105444
99Estrogen signaling pathway_Homo sapiens_hsa049150.48254247
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48026757

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »