KRT8P39

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication checkpoint (GO:0000076)4.93778410
2CENP-A containing nucleosome assembly (GO:0034080)4.50796299
3chromatin remodeling at centromere (GO:0031055)4.42279844
4nuclear pore complex assembly (GO:0051292)4.30896988
5regulation of centriole replication (GO:0046599)4.27384445
6DNA replication-dependent nucleosome assembly (GO:0006335)4.11546142
7DNA replication-dependent nucleosome organization (GO:0034723)4.11546142
8protein localization to kinetochore (GO:0034501)4.10376296
9nuclear pore organization (GO:0006999)4.04026905
10mRNA cleavage (GO:0006379)3.85015942
11regulation of mitochondrial translation (GO:0070129)3.82331961
12response to food (GO:0032094)3.78838039
13mitotic sister chromatid cohesion (GO:0007064)3.76067244
14ribosome assembly (GO:0042255)3.66989510
15DNA replication-independent nucleosome assembly (GO:0006336)3.65342794
16DNA replication-independent nucleosome organization (GO:0034724)3.65342794
17DNA strand elongation (GO:0022616)3.65006845
18DNA ligation (GO:0006266)3.63337466
19transcription from mitochondrial promoter (GO:0006390)3.59690963
20telomere maintenance via semi-conservative replication (GO:0032201)3.55985159
21DNA strand elongation involved in DNA replication (GO:0006271)3.54842760
22histone exchange (GO:0043486)3.54742376
23telomere maintenance via recombination (GO:0000722)3.45033375
24mitochondrial RNA metabolic process (GO:0000959)3.44834564
25mitotic metaphase plate congression (GO:0007080)3.43505861
26sister chromatid segregation (GO:0000819)3.34705706
27non-recombinational repair (GO:0000726)3.33643305
28double-strand break repair via nonhomologous end joining (GO:0006303)3.33643305
29regulation of helicase activity (GO:0051095)3.30333080
30inner mitochondrial membrane organization (GO:0007007)3.29927127
31DNA double-strand break processing (GO:0000729)3.29591312
32pore complex assembly (GO:0046931)3.29181604
33metaphase plate congression (GO:0051310)3.25605657
34mitotic recombination (GO:0006312)3.24377680
35mitotic nuclear envelope disassembly (GO:0007077)3.21091801
36kinetochore organization (GO:0051383)3.20251676
37protein localization to chromosome, centromeric region (GO:0071459)3.17399553
38prenylation (GO:0097354)3.12958837
39protein prenylation (GO:0018342)3.12958837
40mitotic G2/M transition checkpoint (GO:0044818)3.11488799
41mitotic sister chromatid segregation (GO:0000070)3.08760106
42growth hormone secretion (GO:0030252)3.08173004
43regulation of mitotic spindle checkpoint (GO:1903504)3.07574687
44regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.07574687
45pseudouridine synthesis (GO:0001522)3.04695990
46regulation of nuclear cell cycle DNA replication (GO:0033262)3.01424844
47mitotic chromosome condensation (GO:0007076)3.00806081
48meiotic chromosome segregation (GO:0045132)2.99590392
49establishment of integrated proviral latency (GO:0075713)2.99205824
50female gonad development (GO:0008585)2.97827500
51ribosomal large subunit biogenesis (GO:0042273)2.97170717
52pre-miRNA processing (GO:0031054)2.97160951
53maturation of 5.8S rRNA (GO:0000460)2.93317931
54proteasome assembly (GO:0043248)2.91318370
55regulation of centrosome cycle (GO:0046605)2.91005178
56DNA replication initiation (GO:0006270)2.90897035
57regulation of centrosome duplication (GO:0010824)2.90766165
58telomere maintenance via telomere lengthening (GO:0010833)2.89508459
59formation of translation preinitiation complex (GO:0001731)2.88805117
60somatic diversification of immune receptors via somatic mutation (GO:0002566)2.88031429
61somatic hypermutation of immunoglobulin genes (GO:0016446)2.88031429
62ribosome biogenesis (GO:0042254)2.86979078
63negative regulation of DNA-dependent DNA replication (GO:2000104)2.84130716
64centriole replication (GO:0007099)2.83272003
65telomere maintenance (GO:0000723)2.80888630
66chromatin assembly or disassembly (GO:0006333)2.80271807
67telomere organization (GO:0032200)2.79782219
68nuclear envelope disassembly (GO:0051081)2.79607067
69membrane disassembly (GO:0030397)2.79607067
70establishment of protein localization to mitochondrial membrane (GO:0090151)2.78393456
71galactose catabolic process (GO:0019388)2.78171853
72IMP biosynthetic process (GO:0006188)2.77075710
73telomere maintenance via telomerase (GO:0007004)2.76798808
74folic acid-containing compound biosynthetic process (GO:0009396)2.75069117
75DNA damage response, detection of DNA damage (GO:0042769)2.73163410
76ribonucleoprotein complex biogenesis (GO:0022613)2.71914181
77kinetochore assembly (GO:0051382)2.70559288
78base-excision repair, AP site formation (GO:0006285)2.68553737
79DNA geometric change (GO:0032392)2.68058370
80transcription elongation from RNA polymerase I promoter (GO:0006362)2.67364593
81DNA duplex unwinding (GO:0032508)2.65551524
82recombinational repair (GO:0000725)2.65298629
83pteridine-containing compound biosynthetic process (GO:0042559)2.65028742
84double-strand break repair via homologous recombination (GO:0000724)2.64086988
85negative regulation of DNA recombination (GO:0045910)2.63248392
86L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.62008402
87nucleotide-excision repair, DNA gap filling (GO:0006297)2.61636601
88establishment of viral latency (GO:0019043)2.61206945
89regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.58899758
90regulation of mitotic metaphase/anaphase transition (GO:0030071)2.58899758
91somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.58819278
92isotype switching (GO:0045190)2.58819278
93somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.58819278
94respiratory chain complex IV assembly (GO:0008535)2.58680812
95termination of RNA polymerase I transcription (GO:0006363)2.57551786
96dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.55016998
97replication fork processing (GO:0031297)2.54551626
98regulation of DNA-dependent DNA replication (GO:0090329)2.53821211
99regulation of growth hormone secretion (GO:0060123)2.53034306
100positive regulation of chromosome segregation (GO:0051984)2.52038970

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.34988272
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.84148112
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.24317399
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.12561720
5E2F4_17652178_ChIP-ChIP_JURKAT_Human4.05292107
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.70407482
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.22148942
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.21211226
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.19492994
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.91312123
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.86331436
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.85105649
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.65858048
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.61817568
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.52868730
16AR_21909140_ChIP-Seq_LNCAP_Human2.52175255
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.41691457
18E2F1_21310950_ChIP-Seq_MCF-7_Human2.41316079
19FOXP3_21729870_ChIP-Seq_TREG_Human2.41021203
20ELK1_19687146_ChIP-ChIP_HELA_Human2.37546868
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.31199845
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.30160254
23DCP1A_22483619_ChIP-Seq_HELA_Human2.21127861
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.18502729
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.14754367
26THAP11_20581084_ChIP-Seq_MESCs_Mouse2.14049372
27VDR_23849224_ChIP-Seq_CD4+_Human2.09965385
28MYC_19079543_ChIP-ChIP_MESCs_Mouse2.07433715
29POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.99395264
30KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.98690500
31PADI4_21655091_ChIP-ChIP_MCF-7_Human1.95480830
32YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.93053829
33EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.91377115
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91374416
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.89542717
36GABP_19822575_ChIP-Seq_HepG2_Human1.85608744
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.85560207
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.84751451
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.81641981
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.77686479
41XRN2_22483619_ChIP-Seq_HELA_Human1.75751230
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.71577921
43TTF2_22483619_ChIP-Seq_HELA_Human1.70796361
44KDM5A_27292631_Chip-Seq_BREAST_Human1.66794928
45PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.65863835
46MYC_18940864_ChIP-ChIP_HL60_Human1.63646657
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.61036282
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49668807
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.48364402
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.47350351
51E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.47055614
52HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.44742663
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.34770854
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.33260761
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31670820
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.29798899
57SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.27755235
58CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.24422346
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21701183
60EWS_26573619_Chip-Seq_HEK293_Human1.20845714
61ELF1_17652178_ChIP-ChIP_JURKAT_Human1.20658687
62SOX2_16153702_ChIP-ChIP_HESCs_Human1.19695177
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16854152
64NANOG_16153702_ChIP-ChIP_HESCs_Human1.15737601
65SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11374397
66STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09732875
67DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09590086
68DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08159354
69GATA6_25053715_ChIP-Seq_YYC3_Human1.07240529
70ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04076728
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03805327
72GATA1_22025678_ChIP-Seq_K562_Human0.97450638
73BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96432100
74EGR1_23403033_ChIP-Seq_LIVER_Mouse0.94945943
75POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89703870
76SOX17_20123909_ChIP-Seq_XEN_Mouse0.86269888
77ELK1_22589737_ChIP-Seq_MCF10A_Human0.85703522
78TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.85373730
79ZNF263_19887448_ChIP-Seq_K562_Human0.84586236
80CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.83915025
81TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.83611858
82SOX2_18555785_ChIP-Seq_MESCs_Mouse0.82902736
83STAT3_1855785_ChIP-Seq_MESCs_Mouse0.80250312
84ELF5_23300383_ChIP-Seq_T47D_Human0.80037644
85SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.79234574
86NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.78757636
87CHD1_26751641_Chip-Seq_LNCaP_Human0.78578761
88CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.77006733
89SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.75864186
90PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.75025057
91CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.74962280
92NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.74559674
93KLF4_18555785_ChIP-Seq_MESCs_Mouse0.72996917
94ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.72053113
95ESR1_21235772_ChIP-Seq_MCF-7_Human0.71982952
96GATA3_24758297_ChIP-Seq_MCF-7_Human0.71745832
97CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.70841204
98FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.70066139
99FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.69844187
100EOMES_21245162_ChIP-Seq_HESCs_Human0.69748128

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.46974099
2MP0010094_abnormal_chromosome_stability4.35334109
3MP0004957_abnormal_blastocyst_morpholog3.62539567
4MP0008057_abnormal_DNA_replication3.43795024
5MP0008058_abnormal_DNA_repair3.31138270
6MP0003941_abnormal_skin_development3.25473988
7MP0003111_abnormal_nucleus_morphology2.99727560
8MP0005083_abnormal_biliary_tract2.89230818
9MP0003890_abnormal_embryonic-extraembry2.87982929
10MP0003077_abnormal_cell_cycle2.81786926
11MP0001986_abnormal_taste_sensitivity2.41296695
12MP0002254_reproductive_system_inflammat2.24387823
13MP0002102_abnormal_ear_morphology2.23323163
14MP0002396_abnormal_hematopoietic_system2.22405330
15MP0002938_white_spotting2.17795095
16MP0008932_abnormal_embryonic_tissue2.17453958
17MP0006035_abnormal_mitochondrial_morpho2.04587113
18MP0003786_premature_aging1.99033396
19MP0008007_abnormal_cellular_replicative1.91272250
20MP0009697_abnormal_copulation1.89246362
21MP0003718_maternal_effect1.82892243
22MP0010352_gastrointestinal_tract_polyps1.82721869
23MP0002160_abnormal_reproductive_system1.74334945
24MP0001293_anophthalmia1.71540452
25MP0010234_abnormal_vibrissa_follicle1.60529897
26MP0004264_abnormal_extraembryonic_tissu1.59360435
27MP0003806_abnormal_nucleotide_metabolis1.56825401
28MP0001697_abnormal_embryo_size1.55059361
29MP0005076_abnormal_cell_differentiation1.53193185
30MP0001730_embryonic_growth_arrest1.49629293
31MP0001672_abnormal_embryogenesis/_devel1.46856075
32MP0005380_embryogenesis_phenotype1.46856075
33MP0003984_embryonic_growth_retardation1.41545185
34MP0002088_abnormal_embryonic_growth/wei1.38315826
35MP0001666_abnormal_nutrient_absorption1.33267276
36MP0003119_abnormal_digestive_system1.32190763
37MP0002084_abnormal_developmental_patter1.30573892
38MP0005220_abnormal_exocrine_pancreas1.28999924
39MP0006292_abnormal_olfactory_placode1.27362567
40MP0002111_abnormal_tail_morphology1.26624987
41MP0000358_abnormal_cell_content/1.20790955
42MP0004197_abnormal_fetal_growth/weight/1.18462189
43MP0001286_abnormal_eye_development1.17049132
44MP0009672_abnormal_birth_weight1.16730418
45MP0002080_prenatal_lethality1.15568544
46MP0002085_abnormal_embryonic_tissue1.15525323
47MP0000383_abnormal_hair_follicle1.14684159
48MP0000350_abnormal_cell_proliferation1.13846144
49MP0000537_abnormal_urethra_morphology1.13672828
50MP0002697_abnormal_eye_size1.13611014
51MP0002086_abnormal_extraembryonic_tissu1.13505239
52MP0010678_abnormal_skin_adnexa1.13235305
53MP0003937_abnormal_limbs/digits/tail_de1.12154773
54MP0006036_abnormal_mitochondrial_physio1.10331130
55MP0002796_impaired_skin_barrier1.10239231
56MP0008875_abnormal_xenobiotic_pharmacok1.09738200
57MP0005266_abnormal_metabolism1.05652496
58MP0003123_paternal_imprinting1.05414951
59MP0005501_abnormal_skin_physiology1.05399966
60MP0009703_decreased_birth_body1.03500312
61MP0008995_early_reproductive_senescence1.02603594
62MP0005367_renal/urinary_system_phenotyp0.97485434
63MP0000516_abnormal_urinary_system0.97485434
64MP0003567_abnormal_fetal_cardiomyocyte0.95308473
65MP0003136_yellow_coat_color0.94860298
66MP0001529_abnormal_vocalization0.90899139
67MP0001764_abnormal_homeostasis0.90437840
68MP0010030_abnormal_orbit_morphology0.89464007
69MP0005389_reproductive_system_phenotype0.88207962
70MP0004019_abnormal_vitamin_homeostasis0.87906997
71MP0003195_calcinosis0.86881835
72MP0002019_abnormal_tumor_incidence0.85998001
73MP0010307_abnormal_tumor_latency0.85676323
74MP0003303_peritoneal_inflammation0.85650883
75MP0004147_increased_porphyrin_level0.85427006
76MP0002060_abnormal_skin_morphology0.85271070
77MP0005174_abnormal_tail_pigmentation0.83047053
78MP0008877_abnormal_DNA_methylation0.82772642
79MP0001929_abnormal_gametogenesis0.82466390
80MP0000313_abnormal_cell_death0.80461289
81MP0002210_abnormal_sex_determination0.80367940
82MP0001145_abnormal_male_reproductive0.80217519
83MP0005394_taste/olfaction_phenotype0.79366299
84MP0005499_abnormal_olfactory_system0.79366299
85MP0000579_abnormal_nail_morphology0.78609173
86MP0001119_abnormal_female_reproductive0.77887750
87MP0001661_extended_life_span0.76401935
88MP0008789_abnormal_olfactory_epithelium0.75228084
89MP0002233_abnormal_nose_morphology0.75087670
90MP0000653_abnormal_sex_gland0.74601555
91MP0001485_abnormal_pinna_reflex0.73692416
92MP0001188_hyperpigmentation0.73334689
93MP0001270_distended_abdomen0.73014801
94MP0000015_abnormal_ear_pigmentation0.71345373
95MP0002177_abnormal_outer_ear0.69988516
96MP0000762_abnormal_tongue_morphology0.69601997
97MP0000428_abnormal_craniofacial_morphol0.67732173
98MP0005365_abnormal_bile_salt0.67478492
99MP0005075_abnormal_melanosome_morpholog0.67325473
100MP0004134_abnormal_chest_morphology0.66988946

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.90971344
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.61809175
3Abnormality of chromosome stability (HP:0003220)3.64790798
4Pancreatic islet-cell hyperplasia (HP:0004510)3.24671929
5Abnormality of the preputium (HP:0100587)3.23077798
6Meckel diverticulum (HP:0002245)3.16816914
7Birth length less than 3rd percentile (HP:0003561)3.12547841
8Aplasia/Hypoplasia of the uvula (HP:0010293)3.09719782
9Abnormality of the ileum (HP:0001549)3.02992751
10Microvesicular hepatic steatosis (HP:0001414)3.00651183
11Hypoglycemic seizures (HP:0002173)2.85470943
12Bifid tongue (HP:0010297)2.74200494
13Anal stenosis (HP:0002025)2.67269874
14Bilateral microphthalmos (HP:0007633)2.62222498
15Abnormality of the pancreatic islet cells (HP:0006476)2.58315028
16Abnormality of endocrine pancreas physiology (HP:0012093)2.58315028
17Ectopic kidney (HP:0000086)2.53382164
18Hyperinsulinemic hypoglycemia (HP:0000825)2.51750531
19Abnormal pancreas size (HP:0012094)2.49915848
20Type I transferrin isoform profile (HP:0003642)2.45390414
21Sloping forehead (HP:0000340)2.45304560
22Clubbing of toes (HP:0100760)2.42530828
23Reduced antithrombin III activity (HP:0001976)2.36448244
24Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.35533833
25Lipid accumulation in hepatocytes (HP:0006561)2.35313783
26Premature ovarian failure (HP:0008209)2.32023455
27Abnormality of methionine metabolism (HP:0010901)2.31262721
28Reticulocytopenia (HP:0001896)2.29961770
29Enlarged kidneys (HP:0000105)2.28483994
30Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.27416371
31Abnormal protein N-linked glycosylation (HP:0012347)2.27416371
32Abnormal protein glycosylation (HP:0012346)2.27416371
33Abnormal glycosylation (HP:0012345)2.27416371
34Abnormality of alanine metabolism (HP:0010916)2.26650755
35Hyperalaninemia (HP:0003348)2.26650755
36Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.26650755
37Hypoglycemic coma (HP:0001325)2.24346583
38Prominent metopic ridge (HP:0005487)2.21175172
39Absent radius (HP:0003974)2.20426215
40Small intestinal stenosis (HP:0012848)2.20203857
41Duodenal stenosis (HP:0100867)2.20203857
42Abnormal lung lobation (HP:0002101)2.15712667
43Abnormality of the duodenum (HP:0002246)2.15318863
44Microretrognathia (HP:0000308)2.14977118
45Symptomatic seizures (HP:0011145)2.12876129
46Nephroblastoma (Wilms tumor) (HP:0002667)2.11397212
47Squamous cell carcinoma (HP:0002860)2.10182024
48Neoplasm of the adrenal cortex (HP:0100641)2.10018451
49Abnormality of DNA repair (HP:0003254)2.09383748
50Progressive muscle weakness (HP:0003323)2.09113915
51Epidermoid cyst (HP:0200040)2.09004517
52Intestinal atresia (HP:0011100)2.08953552
53Aplasia involving forearm bones (HP:0009822)2.06034998
54Absent forearm bone (HP:0003953)2.06034998
55Horseshoe kidney (HP:0000085)2.05696364
56Hypobetalipoproteinemia (HP:0003563)2.05595564
57Absent thumb (HP:0009777)2.03856412
58Embryonal renal neoplasm (HP:0011794)2.03169939
59Anophthalmia (HP:0000528)2.02317709
60Poikiloderma (HP:0001029)2.01939750
61Abnormality of serum amino acid levels (HP:0003112)2.01880150
62Multiple enchondromatosis (HP:0005701)2.01464983
63Abnormality of pyrimidine metabolism (HP:0004353)2.01144473
64Homocystinuria (HP:0002156)2.00549043
65Abnormality of homocysteine metabolism (HP:0010919)2.00549043
66Increased hepatocellular lipid droplets (HP:0006565)2.00470876
67Short thumb (HP:0009778)1.97678890
68Pendular nystagmus (HP:0012043)1.96435015
69Hypergonadotropic hypogonadism (HP:0000815)1.95319846
70Increased CSF lactate (HP:0002490)1.94116546
71Megaloblastic anemia (HP:0001889)1.93630015
72Volvulus (HP:0002580)1.92565928
73Hepatocellular necrosis (HP:0001404)1.88539064
74Abnormal biliary tract physiology (HP:0012439)1.87710454
75Bile duct proliferation (HP:0001408)1.87710454
76Abnormality of the carotid arteries (HP:0005344)1.87301765
77Abnormality of the metopic suture (HP:0005556)1.86009629
78Facial cleft (HP:0002006)1.85713160
79Triphalangeal thumb (HP:0001199)1.85299168
80Neoplasm of the adrenal gland (HP:0100631)1.83164437
81Small hand (HP:0200055)1.83121329
82Ependymoma (HP:0002888)1.81363745
83Cleft eyelid (HP:0000625)1.80876817
84Secondary amenorrhea (HP:0000869)1.80480942
85Methylmalonic aciduria (HP:0012120)1.79497549
86Myelodysplasia (HP:0002863)1.79491444
87Duplicated collecting system (HP:0000081)1.79057298
88Hypoplasia of the pons (HP:0012110)1.77377536
89Abnormality of the parathyroid morphology (HP:0011766)1.76132512
90Increased serum lactate (HP:0002151)1.75285307
91Abnormality of aspartate family amino acid metabolism (HP:0010899)1.74896571
92Anal atresia (HP:0002023)1.74463903
93Abnormality of the lacrimal duct (HP:0011481)1.74170634
94Rib fusion (HP:0000902)1.72727172
95Proximal placement of thumb (HP:0009623)1.72195788
96Choanal atresia (HP:0000453)1.69804929
97Intestinal fistula (HP:0100819)1.69691630
98Abnormality of the nasal septum (HP:0000419)1.68203050
99Hepatic necrosis (HP:0002605)1.66923719
100Rectal fistula (HP:0100590)1.66382677

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK3.82586374
2LATS13.52375884
3PDK23.36465195
4CDC73.33807758
5ACVR1B3.12868282
6NUAK13.09626266
7PLK42.86361078
8TLK12.60239651
9ZAK2.51915733
10MST42.42269057
11NEK12.39882786
12TRIM282.22993971
13MKNK22.19409124
14TESK22.18221319
15SRPK12.10877400
16EIF2AK12.03195328
17EPHA22.01537680
18WEE11.95348754
19EIF2AK31.94620169
20STK161.89375691
21RPS6KB21.77685375
22TNIK1.74848767
23TTK1.71815183
24PIM21.68045452
25MST1R1.67808964
26NEK21.66481869
27BUB11.63015866
28VRK21.54104315
29FRK1.53255656
30NME11.45954606
31TSSK61.44348763
32MKNK11.44276919
33BMPR1B1.41285801
34PLK11.39034302
35VRK11.37047063
36AURKB1.27172104
37MAP3K101.27162057
38PLK31.14395305
39CDK121.11667207
40BRSK21.07998970
41STK31.06915257
42ATR0.98409596
43CHEK20.97333856
44EIF2AK20.95177001
45CDK70.94986992
46STK390.93370533
47BRD40.92314676
48OXSR10.90600926
49STK40.89491044
50GRK10.87583037
51CHEK10.85823613
52SCYL20.84998716
53CSNK1G10.84821855
54PASK0.81807098
55SIK30.80145505
56ERBB40.73955397
57MELK0.72877849
58ATM0.72175131
59TAF10.71886525
60NME20.71843505
61MAP3K80.69067424
62CLK10.67538943
63RPS6KA50.65776870
64NEK60.62525953
65AURKA0.57419841
66TGFBR10.55745314
67WNK40.53201152
68CSNK1A1L0.51167664
69BRSK10.49896099
70CSNK1G30.49816677
71LMTK20.49259332
72MET0.48610863
73PIM10.47293418
74RPS6KA40.44606506
75STK100.43414106
76ERBB30.42651870
77CDK10.42317441
78BCKDK0.41683625
79CDK20.41471164
80TIE10.40630436
81MAPKAPK30.40503250
82SIK10.40429910
83NLK0.38613437
84PAK40.38004716
85MTOR0.36781315
86WNK30.34047090
87CDK30.33922945
88FGFR20.33658388
89CSNK2A20.33162518
90CSNK1E0.32734375
91CSNK2A10.31421154
92CAMK1G0.28393449
93FGFR10.26773885
94ALK0.26358660
95PAK20.24397881
96ICK0.24280925
97MATK0.24251346
98PRKAA10.22819589
99PIK3CA0.21356201
100PRKCI0.21303930

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.47972860
2Non-homologous end-joining_Homo sapiens_hsa034503.37260964
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.29535275
4Mismatch repair_Homo sapiens_hsa034303.26386970
5Homologous recombination_Homo sapiens_hsa034402.92702695
6Proteasome_Homo sapiens_hsa030502.82439988
7RNA polymerase_Homo sapiens_hsa030202.72423580
8Base excision repair_Homo sapiens_hsa034102.49458007
9Fanconi anemia pathway_Homo sapiens_hsa034602.48582287
10One carbon pool by folate_Homo sapiens_hsa006702.38751871
11RNA transport_Homo sapiens_hsa030132.24088546
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.11502345
13Ribosome_Homo sapiens_hsa030101.80338902
14Pyrimidine metabolism_Homo sapiens_hsa002401.80044510
15Nucleotide excision repair_Homo sapiens_hsa034201.79167681
16Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.75714427
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.71619385
18Spliceosome_Homo sapiens_hsa030401.68801065
19Glutathione metabolism_Homo sapiens_hsa004801.63539668
20Cell cycle_Homo sapiens_hsa041101.58457607
21RNA degradation_Homo sapiens_hsa030181.58240225
22Steroid biosynthesis_Homo sapiens_hsa001001.57341988
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.57109042
24Vitamin digestion and absorption_Homo sapiens_hsa049771.57066183
25Folate biosynthesis_Homo sapiens_hsa007901.55890647
26Pyruvate metabolism_Homo sapiens_hsa006201.54877785
27Fatty acid elongation_Homo sapiens_hsa000621.52347074
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.37772939
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.36828633
30Propanoate metabolism_Homo sapiens_hsa006401.36304224
31Basal transcription factors_Homo sapiens_hsa030221.35727395
32Systemic lupus erythematosus_Homo sapiens_hsa053221.34630904
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.28080316
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27243093
35Caffeine metabolism_Homo sapiens_hsa002321.23092966
36Galactose metabolism_Homo sapiens_hsa000521.21511250
37Protein export_Homo sapiens_hsa030601.17966080
38Purine metabolism_Homo sapiens_hsa002301.14626088
39Selenocompound metabolism_Homo sapiens_hsa004501.13375688
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10858720
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.05505567
42p53 signaling pathway_Homo sapiens_hsa041151.04079639
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.02262077
44Lysine degradation_Homo sapiens_hsa003101.00323003
45N-Glycan biosynthesis_Homo sapiens_hsa005100.99237953
46Sulfur relay system_Homo sapiens_hsa041220.98284933
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97477506
48mRNA surveillance pathway_Homo sapiens_hsa030150.97063118
49Vitamin B6 metabolism_Homo sapiens_hsa007500.94937748
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.90735133
51Oxidative phosphorylation_Homo sapiens_hsa001900.89908610
52Alcoholism_Homo sapiens_hsa050340.88792639
53Peroxisome_Homo sapiens_hsa041460.84389314
54Biosynthesis of amino acids_Homo sapiens_hsa012300.83735612
55Butanoate metabolism_Homo sapiens_hsa006500.75078608
56Sulfur metabolism_Homo sapiens_hsa009200.74445692
57Parkinsons disease_Homo sapiens_hsa050120.72309977
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71276368
59Huntingtons disease_Homo sapiens_hsa050160.71196582
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.71026510
61Metabolic pathways_Homo sapiens_hsa011000.69194694
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66653477
63Chemical carcinogenesis_Homo sapiens_hsa052040.66329050
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65412758
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.64951281
66Carbon metabolism_Homo sapiens_hsa012000.64101479
67Thyroid cancer_Homo sapiens_hsa052160.61713060
68Fatty acid metabolism_Homo sapiens_hsa012120.61300880
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61293259
70Sphingolipid metabolism_Homo sapiens_hsa006000.60571900
71Other glycan degradation_Homo sapiens_hsa005110.59720367
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58936159
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.58384643
74Fat digestion and absorption_Homo sapiens_hsa049750.56819505
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55544969
76Fructose and mannose metabolism_Homo sapiens_hsa000510.54970017
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52581798
78Fatty acid degradation_Homo sapiens_hsa000710.51293851
79Hedgehog signaling pathway_Homo sapiens_hsa043400.49118499
80Hippo signaling pathway_Homo sapiens_hsa043900.48752558
81Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46713748
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44999633
83Tryptophan metabolism_Homo sapiens_hsa003800.43467134
84Linoleic acid metabolism_Homo sapiens_hsa005910.43266168
85beta-Alanine metabolism_Homo sapiens_hsa004100.41895958
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40600300
87Retinol metabolism_Homo sapiens_hsa008300.40254873
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39773844
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38718601
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38589231
91Ovarian steroidogenesis_Homo sapiens_hsa049130.38353040
92Viral carcinogenesis_Homo sapiens_hsa052030.38021310
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36567605
94Pancreatic secretion_Homo sapiens_hsa049720.36340114
95Ether lipid metabolism_Homo sapiens_hsa005650.36287892
96TGF-beta signaling pathway_Homo sapiens_hsa043500.36228956
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34663830
98Alzheimers disease_Homo sapiens_hsa050100.31333533
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.31101097
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30861385

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