KRT8P33

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1GDP-mannose metabolic process (GO:0019673)5.16346231
2NADH metabolic process (GO:0006734)4.74608053
3angiotensin maturation (GO:0002003)4.58205685
4urea cycle (GO:0000050)4.26408722
5antibacterial humoral response (GO:0019731)4.12509725
6nitrogen cycle metabolic process (GO:0071941)4.01910768
7urea metabolic process (GO:0019627)3.92691698
8antimicrobial humoral response (GO:0019730)3.92020421
9hepatocyte apoptotic process (GO:0097284)3.85018826
10epoxygenase P450 pathway (GO:0019373)3.66953295
11positive regulation of pseudopodium assembly (GO:0031274)3.66092650
12regulation of guanylate cyclase activity (GO:0031282)3.63790649
13N-acetylneuraminate metabolic process (GO:0006054)3.58036739
14protoporphyrinogen IX biosynthetic process (GO:0006782)3.53511525
15Golgi transport vesicle coating (GO:0048200)3.51813622
16COPI coating of Golgi vesicle (GO:0048205)3.51813622
17positive regulation of histone deacetylation (GO:0031065)3.48768577
18regulation of RNA export from nucleus (GO:0046831)3.45940345
19homocysteine metabolic process (GO:0050667)3.25284446
20Arp2/3 complex-mediated actin nucleation (GO:0034314)3.23171685
21regulation of pseudopodium assembly (GO:0031272)3.09708722
22protoporphyrinogen IX metabolic process (GO:0046501)3.03071468
23ribosomal small subunit biogenesis (GO:0042274)3.02652920
24regulation of cellular extravasation (GO:0002691)3.00033322
25regulation of bile acid biosynthetic process (GO:0070857)2.99243316
26nucleotide-sugar biosynthetic process (GO:0009226)2.95806074
27proteasome assembly (GO:0043248)2.93621440
28tolerance induction (GO:0002507)2.91790310
29positive regulation of Cdc42 GTPase activity (GO:0043089)2.91217337
30positive regulation of protein deacetylation (GO:0090312)2.89567699
31amino sugar catabolic process (GO:0046348)2.87722897
32fructose metabolic process (GO:0006000)2.86910339
33base-excision repair, AP site formation (GO:0006285)2.85949534
34response to food (GO:0032094)2.85115126
35ncRNA 3-end processing (GO:0043628)2.76948830
36DNA replication initiation (GO:0006270)2.73029312
37regulation of nucleobase-containing compound transport (GO:0032239)2.70198563
38mitotic chromosome condensation (GO:0007076)2.70132016
39regulation of keratinocyte differentiation (GO:0045616)2.66074504
40spliceosomal tri-snRNP complex assembly (GO:0000244)2.65545722
41negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.65359747
42positive regulation of guanylate cyclase activity (GO:0031284)2.61780752
43regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.61623450
44histone H3-K36 demethylation (GO:0070544)2.59483771
45purine deoxyribonucleotide catabolic process (GO:0009155)2.57597127
46actin nucleation (GO:0045010)2.57506101
47ribosome assembly (GO:0042255)2.52155785
48activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.51876832
49cellular response to cadmium ion (GO:0071276)2.49658781
50pyrimidine dimer repair (GO:0006290)2.48816231
51deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.47952931
52ER overload response (GO:0006983)2.47695061
53hemidesmosome assembly (GO:0031581)2.45219315
54negative regulation of epidermal cell differentiation (GO:0045605)2.44544847
55very-low-density lipoprotein particle assembly (GO:0034379)2.44162156
56sphingomyelin metabolic process (GO:0006684)2.43284882
57formation of translation preinitiation complex (GO:0001731)2.38504850
58defense response to fungus (GO:0050832)2.38503930
59regulation of histone H3-K27 methylation (GO:0061085)2.37634694
60rRNA methylation (GO:0031167)2.37445126
61cytokinetic process (GO:0032506)2.35910355
62calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.34279477
63viral mRNA export from host cell nucleus (GO:0046784)2.33619243
64UV protection (GO:0009650)2.31939526
65nucleoside diphosphate biosynthetic process (GO:0009133)2.31932677
66alkaloid metabolic process (GO:0009820)2.30500850
67ribosomal small subunit assembly (GO:0000028)2.30045066
68mRNA cleavage (GO:0006379)2.28141445
69positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.28042836
70intestinal absorption (GO:0050892)2.26928932
71positive regulation of glycoprotein metabolic process (GO:1903020)2.25565466
72mitotic G1/S transition checkpoint (GO:0044819)2.25257683
73DNA strand elongation involved in DNA replication (GO:0006271)2.24990540
74regulation of triglyceride catabolic process (GO:0010896)2.24808242
75negative regulation of DNA repair (GO:0045738)2.23525578
76DNA strand elongation (GO:0022616)2.22813188
77regulation of histone deacetylation (GO:0031063)2.21383828
78dosage compensation (GO:0007549)2.18459268
79monosaccharide catabolic process (GO:0046365)2.17514397
80antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.17444781
81ribonucleoprotein complex biogenesis (GO:0022613)2.17331885
82low-density lipoprotein particle remodeling (GO:0034374)2.16847333
83eosinophil chemotaxis (GO:0048245)2.16516643
84trophectodermal cell differentiation (GO:0001829)2.16335624
85regulation of cholesterol homeostasis (GO:2000188)2.15371923
86macrophage chemotaxis (GO:0048246)2.14577151
87regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.14557935
88endocrine process (GO:0050886)2.14557935
89regulation of systemic arterial blood pressure by hormone (GO:0001990)2.14557935
90positive regulation of RNA splicing (GO:0033120)2.14266864
91vitamin transport (GO:0051180)2.13474662
92diacylglycerol metabolic process (GO:0046339)2.13169622
93response to laminar fluid shear stress (GO:0034616)2.12947715
94antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.11095337
95nuclear pore complex assembly (GO:0051292)2.10674873
96response to UV-C (GO:0010225)2.10121727
97centriole replication (GO:0007099)2.09887905
98positive regulation of glycoprotein biosynthetic process (GO:0010560)2.09740262
99positive regulation of epidermal cell differentiation (GO:0045606)2.09627299
100ribosome biogenesis (GO:0042254)2.09315253

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.79972395
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.49882244
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.47393054
4ELF1_17652178_ChIP-ChIP_JURKAT_Human2.46652910
5MYC_22102868_ChIP-Seq_BL_Human2.42215993
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.16209887
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.15771744
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.12379475
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.11587783
10DCP1A_22483619_ChIP-Seq_HELA_Human2.05099146
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.02617457
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.98013766
13VDR_21846776_ChIP-Seq_THP-1_Human1.94387044
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.92492697
15TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82751667
16ESR1_15608294_ChIP-ChIP_MCF-7_Human1.81270831
17TP63_17297297_ChIP-ChIP_HaCaT_Human1.73039192
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.70611152
19MYC_18358816_ChIP-ChIP_MESCs_Mouse1.69465455
20HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.66799418
21XRN2_22483619_ChIP-Seq_HELA_Human1.65774462
22NELFA_20434984_ChIP-Seq_ESCs_Mouse1.62318604
23FOXM1_23109430_ChIP-Seq_U2OS_Human1.62023106
24KDM5A_27292631_Chip-Seq_BREAST_Human1.61187171
25GATA6_25053715_ChIP-Seq_YYC3_Human1.61017173
26DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.60636764
27CIITA_25753668_ChIP-Seq_RAJI_Human1.59708033
28E2F4_17652178_ChIP-ChIP_JURKAT_Human1.59324804
29GABP_19822575_ChIP-Seq_HepG2_Human1.56551544
30ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.56432072
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.55708966
32MYC_19030024_ChIP-ChIP_MESCs_Mouse1.54521220
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.53407338
34SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.48427402
35MYC_19079543_ChIP-ChIP_MESCs_Mouse1.45473128
36RACK7_27058665_Chip-Seq_MCF-7_Human1.44127086
37KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.41812754
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39509505
39TET1_21451524_ChIP-Seq_MESCs_Mouse1.37337573
40GABP_17652178_ChIP-ChIP_JURKAT_Human1.37275969
41MAF_26560356_Chip-Seq_TH1_Human1.35887389
42ELK3_25401928_ChIP-Seq_HUVEC_Human1.35176778
43CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.34423790
44FOXP3_21729870_ChIP-Seq_TREG_Human1.33780856
45MYB_26560356_Chip-Seq_TH1_Human1.33232321
46EGR1_23403033_ChIP-Seq_LIVER_Mouse1.31916446
47ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.31713259
48KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.31688553
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30495217
50VDR_23849224_ChIP-Seq_CD4+_Human1.30380603
51CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.28196164
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26440135
53ATF3_27146783_Chip-Seq_COLON_Human1.25586558
54MAF_26560356_Chip-Seq_TH2_Human1.25325450
55ZNF263_19887448_ChIP-Seq_K562_Human1.25302115
56BCOR_27268052_Chip-Seq_Bcells_Human1.24959250
57BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.24865440
58PPARA_22158963_ChIP-Seq_LIVER_Mouse1.24857622
59MYB_26560356_Chip-Seq_TH2_Human1.24252667
60SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.20825013
61CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.20494799
62KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.19669022
63CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.19129698
64ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19025939
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.18803592
66POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.18037151
67AR_21909140_ChIP-Seq_LNCAP_Human1.17180020
68KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16482995
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.15996272
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15881915
71E2F1_18555785_ChIP-Seq_MESCs_Mouse1.15285991
72P68_20966046_ChIP-Seq_HELA_Human1.13820294
73RARG_19884340_ChIP-ChIP_MEFs_Mouse1.12909419
74UTX_26944678_Chip-Seq_JUKART_Human1.12608427
75STAT4_19710469_ChIP-ChIP_TH1__Mouse1.12480195
76ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12263507
77KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11579434
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10735803
79GATA4_25053715_ChIP-Seq_YYC3_Human1.10373910
80KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09798845
81RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08690467
82LXR_22292898_ChIP-Seq_THP-1_Human1.08539012
83SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.07803332
84MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.07726250
85ELF1_20517297_ChIP-Seq_JURKAT_Human1.07425516
86PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.06974696
87SOX2_27498859_Chip-Seq_STOMACH_Mouse1.05941449
88TFEB_21752829_ChIP-Seq_HELA_Human1.05925251
89CREB1_15753290_ChIP-ChIP_HEK293T_Human1.05770201
90STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.04999264
91CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04755854
92NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04201625
93BCL6_27268052_Chip-Seq_Bcells_Human1.03346298
94E2F1_21310950_ChIP-Seq_MCF-7_Human1.01748900
95HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01676292
96EST1_17652178_ChIP-ChIP_JURKAT_Human1.00679064
97THAP11_20581084_ChIP-Seq_MESCs_Mouse1.00363639
98E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99986993
99MYCN_18555785_ChIP-Seq_MESCs_Mouse0.99721028
100NCOR1_26117541_ChIP-Seq_K562_Human0.99499311

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.73960875
2MP0005083_abnormal_biliary_tract3.68892681
3MP0005451_abnormal_body_composition3.61080899
4MP0001666_abnormal_nutrient_absorption2.93264479
5MP0003763_abnormal_thymus_physiology2.79643458
6MP0010352_gastrointestinal_tract_polyps2.54994424
7MP0003693_abnormal_embryo_hatching2.54933291
8MP0005085_abnormal_gallbladder_physiolo2.54295882
9MP0002139_abnormal_hepatobiliary_system2.47947311
10MP0010234_abnormal_vibrissa_follicle2.43162322
11MP0005365_abnormal_bile_salt2.40522848
12MP0001873_stomach_inflammation2.40248604
13MP0008057_abnormal_DNA_replication2.35611480
14MP0009840_abnormal_foam_cell2.23374550
15MP0004264_abnormal_extraembryonic_tissu2.17271426
16MP0002796_impaired_skin_barrier2.12552238
17MP0000490_abnormal_crypts_of2.11065644
18MP0010155_abnormal_intestine_physiology2.06575889
19MP0008961_abnormal_basal_metabolism1.94144842
20MP0008260_abnormal_autophagy1.93200827
21MP0004957_abnormal_blastocyst_morpholog1.91468369
22MP0003806_abnormal_nucleotide_metabolis1.89444708
23MP0008058_abnormal_DNA_repair1.80954221
24MP0005501_abnormal_skin_physiology1.74874009
25MP0003866_abnormal_defecation1.70008361
26MP0004019_abnormal_vitamin_homeostasis1.66495843
27MP0002163_abnormal_gland_morphology1.66187342
28MP0003252_abnormal_bile_duct1.63401862
29MP0003111_abnormal_nucleus_morphology1.62389176
30MP0009333_abnormal_splenocyte_physiolog1.57233938
31MP0000537_abnormal_urethra_morphology1.53850459
32MP0010094_abnormal_chromosome_stability1.52671547
33MP0003077_abnormal_cell_cycle1.42250932
34MP0000003_abnormal_adipose_tissue1.41640038
35MP0001730_embryonic_growth_arrest1.39225931
36MP0005058_abnormal_lysosome_morphology1.38188247
37MP0002138_abnormal_hepatobiliary_system1.36710346
38MP0003221_abnormal_cardiomyocyte_apopto1.33637878
39MP0009643_abnormal_urine_homeostasis1.33021491
40MP0005670_abnormal_white_adipose1.31093836
41MP0000477_abnormal_intestine_morphology1.28495939
42MP0002396_abnormal_hematopoietic_system1.26808004
43MP0009379_abnormal_foot_pigmentation1.26365053
44MP0003315_abnormal_perineum_morphology1.25341868
45MP0008007_abnormal_cellular_replicative1.24446864
46MP0006035_abnormal_mitochondrial_morpho1.14848138
47MP0003868_abnormal_feces_composition1.11803107
48MP0002166_altered_tumor_susceptibility1.08682095
49MP0001800_abnormal_humoral_immune1.08254808
50MP0010329_abnormal_lipoprotein_level1.06357185
51MP0005076_abnormal_cell_differentiation1.05606417
52MP0003786_premature_aging1.05460388
53MP0001764_abnormal_homeostasis1.04491381
54MP0000703_abnormal_thymus_morphology1.04321974
55MP0001243_abnormal_dermal_layer1.03988903
56MP0002970_abnormal_white_adipose1.03780045
57MP0005375_adipose_tissue_phenotype1.03723497
58MP0002722_abnormal_immune_system1.00601865
59MP0008875_abnormal_xenobiotic_pharmacok0.96956670
60MP0002019_abnormal_tumor_incidence0.96319453
61MP0000015_abnormal_ear_pigmentation0.94584085
62MP0000609_abnormal_liver_physiology0.94558041
63MP0003718_maternal_effect0.94015474
64MP0001845_abnormal_inflammatory_respons0.92430323
65MP0003436_decreased_susceptibility_to0.91804288
66MP0005409_darkened_coat_color0.91585786
67MP0002136_abnormal_kidney_physiology0.90611235
68MP0003959_abnormal_lean_body0.87867665
69MP0001819_abnormal_immune_cell0.87834110
70MP0002420_abnormal_adaptive_immunity0.87376748
71MP0009115_abnormal_fat_cell0.86821283
72MP0000689_abnormal_spleen_morphology0.85066824
73MP0003566_abnormal_cell_adhesion0.84557705
74MP0002398_abnormal_bone_marrow0.84346701
75MP0000716_abnormal_immune_system0.83370282
76MP0001216_abnormal_epidermal_layer0.83303907
77MP0002006_tumorigenesis0.82862708
78MP0004782_abnormal_surfactant_physiolog0.82632810
79MP0000350_abnormal_cell_proliferation0.82598654
80MP0002098_abnormal_vibrissa_morphology0.82299232
81MP0000598_abnormal_liver_morphology0.81845151
82MP0004947_skin_inflammation0.81136117
83MP0000538_abnormal_urinary_bladder0.80958491
84MP0005310_abnormal_salivary_gland0.80814265
85MP0000462_abnormal_digestive_system0.80659702
86MP0005666_abnormal_adipose_tissue0.79996171
87MP0005266_abnormal_metabolism0.79665923
88MP0002452_abnormal_antigen_presenting0.79518568
89MP0002877_abnormal_melanocyte_morpholog0.79304931
90MP0005332_abnormal_amino_acid0.78720867
91MP0003091_abnormal_cell_migration0.78214340
92MP0002429_abnormal_blood_cell0.78181681
93MP0005025_abnormal_response_to0.76402181
94MP0000313_abnormal_cell_death0.76378438
95MP0005334_abnormal_fat_pad0.76218377
96MP0009931_abnormal_skin_appearance0.75620945
97MP0004185_abnormal_adipocyte_glucose0.74887713
98MP0000858_altered_metastatic_potential0.74348184
99MP0002080_prenatal_lethality0.73913199
100MP0002086_abnormal_extraembryonic_tissu0.73641171

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glutamine family amino acid metabolism (HP:0010902)4.93254491
2Malnutrition (HP:0004395)4.08084796
3Alopecia of scalp (HP:0002293)3.55299520
4Microvesicular hepatic steatosis (HP:0001414)3.44531799
5Hypobetalipoproteinemia (HP:0003563)3.09926945
6Abnormality of pyrimidine metabolism (HP:0004353)3.01114188
7Upper limb amyotrophy (HP:0009129)2.97961601
8Distal upper limb amyotrophy (HP:0007149)2.97961601
9Abnormality of monocarboxylic acid metabolism (HP:0010996)2.92308557
10Pustule (HP:0200039)2.85872875
11Hand muscle atrophy (HP:0009130)2.80000751
12Abnormal tarsal ossification (HP:0008369)2.74283474
13Micronodular cirrhosis (HP:0001413)2.73987635
14Urethral obstruction (HP:0000796)2.73911793
15Increased connective tissue (HP:0009025)2.60813719
16Increased muscle lipid content (HP:0009058)2.60772923
17Flat acetabular roof (HP:0003180)2.59075011
18Ureteral stenosis (HP:0000071)2.58090279
19Nausea (HP:0002018)2.53448054
20Proximal tubulopathy (HP:0000114)2.52992651
21Increased intramyocellular lipid droplets (HP:0012240)2.51138089
22Chronic diarrhea (HP:0002028)2.45415207
23Renal tubular acidosis (HP:0001947)2.44677413
24Sparse lateral eyebrow (HP:0005338)2.40982758
25Abnormality of the distal phalanges of the toes (HP:0010182)2.38337856
26Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.34052931
27Abdominal distention (HP:0003270)2.33020917
28Reduced antithrombin III activity (HP:0001976)2.29111837
29Abnormal foot bone ossification (HP:0010675)2.27456640
30Eczematoid dermatitis (HP:0000976)2.27123515
31Difficulty climbing stairs (HP:0003551)2.23092922
32Villous atrophy (HP:0011473)2.22835132
33Abnormality of small intestinal villus morphology (HP:0011472)2.22835132
34Poikiloderma (HP:0001029)2.21500635
35Abnormality of urine glucose concentration (HP:0011016)2.21177353
36Glycosuria (HP:0003076)2.21177353
37Ureteral obstruction (HP:0006000)2.20418180
38Microretrognathia (HP:0000308)2.20106299
39IgM deficiency (HP:0002850)2.15614171
40Abnormal hair laboratory examination (HP:0003328)2.15607942
41Anteriorly placed anus (HP:0001545)2.15145455
42Subacute progressive viral hepatitis (HP:0006572)2.14307661
43Milia (HP:0001056)2.13047550
44Abnormal pancreas size (HP:0012094)2.11669241
45Alkalosis (HP:0001948)2.10865567
46IgA deficiency (HP:0002720)2.10748489
47Widely patent fontanelles and sutures (HP:0004492)2.09361759
48Hydroxyprolinuria (HP:0003080)2.09249681
49Abnormality of proline metabolism (HP:0010907)2.09249681
50Entropion (HP:0000621)2.05757504
51Abnormality of B cell number (HP:0010975)2.05235471
52Wide cranial sutures (HP:0010537)2.02132706
53Abnormality of the vitamin B12 metabolism (HP:0004341)2.01825480
54Prolonged partial thromboplastin time (HP:0003645)2.01793726
55Back pain (HP:0003418)2.00437543
56Hyperammonemia (HP:0001987)1.99746421
57Thick nail (HP:0001805)1.97394951
58Hypoplasia of the thymus (HP:0000778)1.95101077
59B lymphocytopenia (HP:0010976)1.94014868
60Broad face (HP:0000283)1.90438510
61Progressive hearing impairment (HP:0001730)1.90231234
62Renal tubular dysfunction (HP:0000124)1.86566245
63Squamous cell carcinoma (HP:0002860)1.86396284
64Conjugated hyperbilirubinemia (HP:0002908)1.85223215
65Rhabdomyolysis (HP:0003201)1.84479662
66Recurrent bronchitis (HP:0002837)1.82350567
67Abnormality of the preputium (HP:0100587)1.81880974
68Birth length less than 3rd percentile (HP:0003561)1.81801342
69Neonatal respiratory distress (HP:0002643)1.81776640
70Ileus (HP:0002595)1.80955716
71Periodontitis (HP:0000704)1.78277764
72Fat malabsorption (HP:0002630)1.77970156
73Generalized hyperpigmentation (HP:0007440)1.77729584
74Hemorrhage of the eye (HP:0011885)1.77454128
75Abnormality of dicarboxylic acid metabolism (HP:0010995)1.76905545
76Dicarboxylic aciduria (HP:0003215)1.76905545
77Abnormality of the prostate (HP:0008775)1.75473124
78Abnormality of nucleobase metabolism (HP:0010932)1.74888080
79Pili torti (HP:0003777)1.74592338
80Autoimmune hemolytic anemia (HP:0001890)1.74427190
81Abnormality of T cells (HP:0002843)1.73951381
82Xanthomatosis (HP:0000991)1.73841033
83Right ventricular cardiomyopathy (HP:0011663)1.73309145
84Fragile skin (HP:0001030)1.73267496
85Hyperphosphaturia (HP:0003109)1.72992238
86Abnormal urine phosphate concentration (HP:0012599)1.72209960
87T lymphocytopenia (HP:0005403)1.71786413
88Long foot (HP:0001833)1.71352967
89Cutaneous photosensitivity (HP:0000992)1.71127809
90Flattened epiphyses (HP:0003071)1.69404109
91Abnormality of vitamin B metabolism (HP:0004340)1.69357049
92Hyperuricemia (HP:0002149)1.69127855
93Increased purine levels (HP:0004368)1.69127855
94Abnormality of T cell number (HP:0011839)1.68937466
95Abnormality of aspartate family amino acid metabolism (HP:0010899)1.68851033
96Metabolic acidosis (HP:0001942)1.68040838
97IgG deficiency (HP:0004315)1.66426866
98Severe combined immunodeficiency (HP:0004430)1.65553715
99External ophthalmoplegia (HP:0000544)1.65503028
100Megaloblastic anemia (HP:0001889)1.65483436

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.38413494
2SMG14.31020892
3NEK24.29560240
4MST1R3.15303161
5CDK122.92336742
6ERN12.84909716
7TESK22.67403403
8CCNB12.56921202
9VRK22.35742810
10RPS6KB22.21277491
11MAP4K11.93736546
12TLK11.87588436
13PDK21.72923616
14EIF2AK31.69479757
15EIF2AK11.67676306
16PASK1.61670226
17MST41.58899175
18CAMKK21.58544936
19ACVR1B1.58254967
20PBK1.55442147
21FGFR41.41820323
22GRK61.33082630
23BUB11.32707176
24ZAK1.31478098
25NME21.30210803
26AURKB1.30057405
27PAK41.29643997
28SIK31.27484270
29TESK11.27396471
30TRIB31.20406134
31CDK91.19991048
32STK101.19506375
33ICK1.19080070
34MAPK111.18410326
35MELK1.17898227
36PRPF4B1.16733616
37CHUK1.14793610
38MAP3K121.13723132
39RPS6KA41.11262417
40CAMK1D1.09503766
41LRRK21.08911570
42SIK11.05782689
43TAF10.99338409
44SCYL20.95821501
45MAP3K100.91083880
46TBK10.87649789
47MAP3K80.85980544
48IRAK30.83239417
49CHEK10.81766866
50PRKG20.80511652
51VRK10.79783769
52ZAP700.79578473
53CDK40.78129824
54DAPK10.77763461
55TXK0.75608989
56MAP2K20.74743868
57PTK60.74227758
58CAMKK10.72401768
59AURKA0.69784068
60STK40.69591509
61CDC70.69071200
62CDK60.68046902
63CDK70.66028782
64MAP3K130.64082771
65MYLK0.61291655
66DAPK30.58196205
67RPS6KA50.56915370
68MAP3K140.56228165
69PIM20.55834570
70KSR20.53721959
71MET0.53452766
72MTOR0.53204749
73MAP3K30.51706892
74ITK0.51008647
75BLK0.50939553
76WNK40.50739734
77STK390.50457325
78ATR0.48559970
79LMTK20.48252320
80PIM10.47653885
81MAP3K20.45036649
82IKBKB0.44614356
83MAP3K70.43240867
84IKBKE0.42374056
85EPHB10.41841807
86LCK0.40459828
87AKT20.39312553
88MAP3K10.38814102
89PLK10.34150298
90CHEK20.33587349
91RIPK10.32655136
92MAPKAPK30.32249878
93CAMK40.31797305
94CLK10.31296749
95CDK80.30455403
96BMPR20.30331543
97CDK20.29643706
98PAK20.29418046
99PRKCI0.27888352
100CDK10.27071134

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.80130320
2Vitamin digestion and absorption_Homo sapiens_hsa049773.40006860
3Fructose and mannose metabolism_Homo sapiens_hsa000513.27851603
4Fat digestion and absorption_Homo sapiens_hsa049752.88278936
5DNA replication_Homo sapiens_hsa030302.73672307
6Renin-angiotensin system_Homo sapiens_hsa046142.57739645
7Arginine biosynthesis_Homo sapiens_hsa002202.57652269
8Sulfur relay system_Homo sapiens_hsa041222.45351577
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.31371229
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.16682789
11Systemic lupus erythematosus_Homo sapiens_hsa053222.10611994
12Spliceosome_Homo sapiens_hsa030402.08151130
13Base excision repair_Homo sapiens_hsa034101.98261391
14Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.91900888
15Proteasome_Homo sapiens_hsa030501.88076418
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.66716702
17Pentose phosphate pathway_Homo sapiens_hsa000301.65096514
18Primary immunodeficiency_Homo sapiens_hsa053401.63521709
19Chemical carcinogenesis_Homo sapiens_hsa052041.52839531
20Sulfur metabolism_Homo sapiens_hsa009201.50925544
21Viral carcinogenesis_Homo sapiens_hsa052031.50708951
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.47650529
23Glutathione metabolism_Homo sapiens_hsa004801.47217036
24Galactose metabolism_Homo sapiens_hsa000521.47123751
25Thyroid cancer_Homo sapiens_hsa052161.43032866
26Biosynthesis of amino acids_Homo sapiens_hsa012301.42479094
27Mismatch repair_Homo sapiens_hsa034301.35321891
28Caffeine metabolism_Homo sapiens_hsa002321.32461968
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.22959704
30Pyrimidine metabolism_Homo sapiens_hsa002401.18810000
31T cell receptor signaling pathway_Homo sapiens_hsa046601.17639062
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.17316323
33Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.11826669
34Carbon metabolism_Homo sapiens_hsa012001.10456132
35Alcoholism_Homo sapiens_hsa050341.10307464
36mRNA surveillance pathway_Homo sapiens_hsa030151.09004974
37Phenylalanine metabolism_Homo sapiens_hsa003601.07447832
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.04316047
39RNA transport_Homo sapiens_hsa030131.04268797
40Folate biosynthesis_Homo sapiens_hsa007901.02731247
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02035702
42Drug metabolism - other enzymes_Homo sapiens_hsa009831.01562187
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.00839885
44Epstein-Barr virus infection_Homo sapiens_hsa051690.93602282
45Starch and sucrose metabolism_Homo sapiens_hsa005000.89778187
46Glycerolipid metabolism_Homo sapiens_hsa005610.87671434
47Ribosome_Homo sapiens_hsa030100.86375508
48Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.86261298
49Other glycan degradation_Homo sapiens_hsa005110.83904911
50Maturity onset diabetes of the young_Homo sapiens_hsa049500.82746427
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.81102979
52Nucleotide excision repair_Homo sapiens_hsa034200.81004372
53Steroid hormone biosynthesis_Homo sapiens_hsa001400.80522776
54Cell cycle_Homo sapiens_hsa041100.80504317
55Hepatitis C_Homo sapiens_hsa051600.80432506
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78406994
57Arginine and proline metabolism_Homo sapiens_hsa003300.78139367
58Herpes simplex infection_Homo sapiens_hsa051680.76081781
59Protein digestion and absorption_Homo sapiens_hsa049740.73296653
60Intestinal immune network for IgA production_Homo sapiens_hsa046720.71824237
61p53 signaling pathway_Homo sapiens_hsa041150.69666921
62Retinol metabolism_Homo sapiens_hsa008300.67519100
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66030496
64Pancreatic cancer_Homo sapiens_hsa052120.62802737
65Lysine degradation_Homo sapiens_hsa003100.61848449
66N-Glycan biosynthesis_Homo sapiens_hsa005100.61289101
67Apoptosis_Homo sapiens_hsa042100.59635191
68RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58096565
69Tryptophan metabolism_Homo sapiens_hsa003800.57608499
70Non-homologous end-joining_Homo sapiens_hsa034500.56532075
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56333951
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52564682
73Vibrio cholerae infection_Homo sapiens_hsa051100.51994410
74Pyruvate metabolism_Homo sapiens_hsa006200.51727170
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51454923
76Bile secretion_Homo sapiens_hsa049760.49798612
77RNA polymerase_Homo sapiens_hsa030200.49538028
78Acute myeloid leukemia_Homo sapiens_hsa052210.49155056
79Mineral absorption_Homo sapiens_hsa049780.47974826
80HTLV-I infection_Homo sapiens_hsa051660.47651536
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46893069
82Homologous recombination_Homo sapiens_hsa034400.43099675
83Bladder cancer_Homo sapiens_hsa052190.42156008
84Histidine metabolism_Homo sapiens_hsa003400.40790957
85Measles_Homo sapiens_hsa051620.39824328
86Hepatitis B_Homo sapiens_hsa051610.38044538
87Pancreatic secretion_Homo sapiens_hsa049720.37242847
88Fatty acid degradation_Homo sapiens_hsa000710.37102768
89Selenocompound metabolism_Homo sapiens_hsa004500.37045646
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.36795573
91Autoimmune thyroid disease_Homo sapiens_hsa053200.34508387
92Chronic myeloid leukemia_Homo sapiens_hsa052200.33975694
93Arachidonic acid metabolism_Homo sapiens_hsa005900.33959698
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33227228
95Non-small cell lung cancer_Homo sapiens_hsa052230.32143969
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.32078106
97Metabolic pathways_Homo sapiens_hsa011000.31765502
98Influenza A_Homo sapiens_hsa051640.31456854
99Fatty acid elongation_Homo sapiens_hsa000620.31275890
100Peroxisome_Homo sapiens_hsa041460.29500451

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