KRT83

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB6, is found primarily in the hair cortex. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of memory T cell differentiation (GO:0043380)9.68781366
2citrulline biosynthetic process (GO:0019240)9.39283186
3hair follicle morphogenesis (GO:0031069)8.98731594
4peptide cross-linking (GO:0018149)8.75649379
5regulation of activation of Janus kinase activity (GO:0010533)8.67881211
6adhesion of symbiont to host (GO:0044406)8.50021995
7positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)8.18759577
8regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)7.34557997
9intermediate filament cytoskeleton organization (GO:0045104)6.90506094
10intermediate filament-based process (GO:0045103)6.68037364
11positive regulation of cell fate commitment (GO:0010455)6.67041599
12ADP metabolic process (GO:0046031)6.67000429
13positive regulation of interleukin-17 production (GO:0032740)6.62749684
14regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)6.51611035
15cell wall macromolecule catabolic process (GO:0016998)6.31932363
16cell wall macromolecule metabolic process (GO:0044036)6.31932363
17citrulline metabolic process (GO:0000052)6.17891653
18deoxyribonucleoside diphosphate metabolic process (GO:0009186)6.17389710
19keratinocyte differentiation (GO:0030216)5.82885433
20* epidermis development (GO:0008544)5.82325549
21hair cycle process (GO:0022405)5.76429531
22molting cycle process (GO:0022404)5.76429531
23establishment of skin barrier (GO:0061436)5.66970277
24negative regulation of interleukin-10 production (GO:0032693)5.64547724
25peptidyl-arginine modification (GO:0018195)5.22084864
26positive regulation of defense response to virus by host (GO:0002230)5.14954549
27positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)5.05464270
28regulation of water loss via skin (GO:0033561)5.04957783
29positive regulation of T-helper 1 type immune response (GO:0002827)5.01212402
30bundle of His cell to Purkinje myocyte communication (GO:0086069)4.90209661
31purine nucleoside diphosphate metabolic process (GO:0009135)4.79865213
32purine ribonucleoside diphosphate metabolic process (GO:0009179)4.79865213
33hemidesmosome assembly (GO:0031581)4.78214740
34regulation of defense response to virus by host (GO:0050691)4.74547587
35positive regulation of keratinocyte differentiation (GO:0045618)4.67089972
36skin morphogenesis (GO:0043589)4.66526368
37long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.59171658
38epidermal cell differentiation (GO:0009913)4.55152937
39positive regulation of T-helper cell differentiation (GO:0045624)4.45291073
40positive regulation of T cell mediated cytotoxicity (GO:0001916)4.35092233
41purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)4.31702390
42cellular response to nicotine (GO:0071316)4.20004116
43long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.09791588
44linoleic acid metabolic process (GO:0043651)4.08618980
45AMP metabolic process (GO:0046033)4.04304847
46regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.03377592
47tooth mineralization (GO:0034505)4.02220412
48* molting cycle (GO:0042303)33.8463281
49* hair cycle (GO:0042633)33.8463281
50keratinocyte development (GO:0003334)3.92537663
51regulation of vitamin D biosynthetic process (GO:0060556)3.89658272
52ribonucleoside diphosphate metabolic process (GO:0009185)3.87798475
53fatty-acyl-CoA biosynthetic process (GO:0046949)3.82505758
54regulation of vitamin metabolic process (GO:0030656)3.75565835
55positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.68399152
56phosphatidylinositol acyl-chain remodeling (GO:0036149)3.68277330
57positive regulation of osteoclast differentiation (GO:0045672)3.62482444
58fatty-acyl-CoA metabolic process (GO:0035337)3.60653555
59regulation of keratinocyte differentiation (GO:0045616)3.57220962
60regulation of T cell mediated cytotoxicity (GO:0001914)3.56468978
61retinol metabolic process (GO:0042572)3.56161682
62N-glycan processing (GO:0006491)3.53281912
63regulation of interleukin-17 production (GO:0032660)3.47026266
64regulation of T-helper 1 type immune response (GO:0002825)3.45976462
65positive regulation of hair cycle (GO:0042635)3.44004701
66positive regulation of hair follicle development (GO:0051798)3.44004701
67phosphatidylserine acyl-chain remodeling (GO:0036150)3.42277377
68hair follicle development (GO:0001942)3.38486127
69multicellular organismal water homeostasis (GO:0050891)3.37578595
70negative regulation of keratinocyte proliferation (GO:0010839)3.30565158
71regulation of interleukin-12 biosynthetic process (GO:0045075)3.26556298
72purine deoxyribonucleotide metabolic process (GO:0009151)3.25199264
73regulation of hair follicle development (GO:0051797)3.17704935
74positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.17421319
75phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.14620578
76negative regulation of establishment of protein localization to plasma membrane (GO:0090005)3.12505978
77regulation of cell fate commitment (GO:0010453)3.09830860
78positive regulation of tyrosine phosphorylation of Stat3 protein (GO:0042517)3.08931486
79gap junction assembly (GO:0016264)3.08649793
80positive regulation of natural killer cell activation (GO:0032816)3.03397760
81bone trabecula formation (GO:0060346)3.00243279
82regulation of T-helper cell differentiation (GO:0045622)2.99872302
83positive regulation of activated T cell proliferation (GO:0042104)2.98893451
84thioester biosynthetic process (GO:0035384)2.98742037
85acyl-CoA biosynthetic process (GO:0071616)2.98742037
86positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.85820375
87primary alcohol metabolic process (GO:0034308)2.84258957
88deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.83494799
89positive regulation of meiotic cell cycle (GO:0051446)2.82630104
90positive regulation of epidermis development (GO:0045684)2.82500590
91defense response to Gram-negative bacterium (GO:0050829)2.78565503
92regulation of natural killer cell activation (GO:0032814)2.77930719
93regulation of epidermal cell differentiation (GO:0045604)2.77427789
94regulation of hair cycle (GO:0042634)2.75816945
95regulation of translational termination (GO:0006449)2.75022803
96water homeostasis (GO:0030104)2.74509793
97* epithelium development (GO:0060429)2.72618268
98regulation of epidermis development (GO:0045682)2.65125725
99polyketide metabolic process (GO:0030638)2.62657356
100doxorubicin metabolic process (GO:0044598)2.62657356
101daunorubicin metabolic process (GO:0044597)2.62657356
102ectoderm development (GO:0007398)2.58157212
103negative regulation of protein localization to plasma membrane (GO:1903077)2.57193864
104phosphatidylserine metabolic process (GO:0006658)2.54513228
105atrioventricular valve morphogenesis (GO:0003181)2.50506961
106epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.49898177
107phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.48976883
108fatty acid elongation (GO:0030497)2.41044023
109positive regulation of T cell mediated immunity (GO:0002711)2.40255624
110negative regulation of cholesterol transport (GO:0032375)2.39606536
111negative regulation of sterol transport (GO:0032372)2.39606536
112regulation of tyrosine phosphorylation of Stat3 protein (GO:0042516)2.37608129
113membrane protein intracellular domain proteolysis (GO:0031293)2.36475725
114positive regulation of lipid storage (GO:0010884)2.35030311
115aminoglycoside antibiotic metabolic process (GO:0030647)2.34865150
116regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.33577024
117positive regulation of monocyte chemotaxis (GO:0090026)2.33023081
118fusion of sperm to egg plasma membrane (GO:0007342)2.31939379
119protein localization to endosome (GO:0036010)2.30632114
120sexual reproduction (GO:0019953)2.30180569
121wound healing, spreading of epidermal cells (GO:0035313)2.29623551
122regulation of ruffle assembly (GO:1900027)2.28703373
123positive regulation of epidermal cell differentiation (GO:0045606)2.25806224
124regulation of mesenchymal cell apoptotic process (GO:2001053)2.25218597
125ventricular cardiac muscle cell action potential (GO:0086005)2.23963356
126cell surface receptor signaling pathway involved in heart development (GO:0061311)2.23640075
127cranial suture morphogenesis (GO:0060363)2.20725452
128phosphatidylcholine acyl-chain remodeling (GO:0036151)2.20348448
129negative regulation of cell fate specification (GO:0009996)2.19651542
130skin development (GO:0043588)2.13539816
131lymph vessel development (GO:0001945)2.03304816
132outflow tract septum morphogenesis (GO:0003148)2.02399853
133negative regulation of epidermis development (GO:0045683)2.01150724
134intermediate filament organization (GO:0045109)12.7443231
135keratinization (GO:0031424)12.0227767
136desmosome organization (GO:0002934)10.2452782
137adhesion of symbiont to host cell (GO:0044650)10.0741584
138virion attachment to host cell (GO:0019062)10.0741584
139epithelial cell-cell adhesion (GO:0090136)1.97617517
140myotube differentiation (GO:0014902)1.95135189
141cytoskeletal anchoring at plasma membrane (GO:0007016)1.91341354
142planar cell polarity pathway involved in neural tube closure (GO:0090179)1.89098275
143regulation of cardioblast differentiation (GO:0051890)1.87419209
144alditol phosphate metabolic process (GO:0052646)1.87067194
145negative regulation of Ras GTPase activity (GO:0034261)1.85439123
146regulation of Wnt signaling pathway involved in heart development (GO:0003307)1.84451679
147antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)1.82209569
148antigen processing and presentation of endogenous peptide antigen (GO:0002483)1.82209569
149regulation of keratinocyte proliferation (GO:0010837)1.82127521
150ephrin receptor signaling pathway (GO:0048013)1.81927961
151regulation of heart rate by cardiac conduction (GO:0086091)1.81835119
152* aging (GO:0007568)1.80007534
153non-canonical Wnt signaling pathway (GO:0035567)1.79580034
154cell-substrate junction assembly (GO:0007044)1.74636648
155cell communication involved in cardiac conduction (GO:0086065)1.73720970
156regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)1.72588421
157primary alcohol catabolic process (GO:0034310)1.72272347
158regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901211.71667867
159response to UV-B (GO:0010224)1.66922589
160cellular modified amino acid biosynthetic process (GO:0042398)1.65836181
161wound healing, spreading of cells (GO:0044319)1.65222037
162very long-chain fatty acid metabolic process (GO:0000038)1.64509335
163regulation of monocyte chemotaxis (GO:0090025)1.64210046
164phosphatidylglycerol metabolic process (GO:0046471)1.62529702
165keratinocyte proliferation (GO:0043616)1.61501616
166cardiac right ventricle morphogenesis (GO:0003215)1.61028952
167embryonic camera-type eye development (GO:0031076)1.59672111
168eyelid development in camera-type eye (GO:0061029)1.59351494

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.44832192
2CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human5.30053813
3P63_26484246_Chip-Seq_KERATINOCYTES_Human3.66151251
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.48759123
5* CTCF_20526341_ChIP-Seq_ESCs_Human2.30870283
6BMI1_19503595_ChIP-Seq_MEFsC_Mouse2.27197316
7* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse2.03699623
8TP63_17297297_ChIP-ChIP_HaCaT_Human12.2652659
9E2F1_20622854_ChIP-Seq_HELA_Human1.99700932
10TAF2_19829295_ChIP-Seq_ESCs_Human1.88600636
11CSB_26484114_Chip-Seq_FIBROBLAST_Human1.84697886
12PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.83843319
13VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.81730074
14EGR1_19032775_ChIP-ChIP_M12_Human1.80087380
15NANOG_20526341_ChIP-Seq_ESCs_Human1.79858407
16P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.78873082
17LXR_22292898_ChIP-Seq_THP-1_Human1.74326211
18BCL6_27268052_Chip-Seq_Bcells_Human1.73577549
19GATA1_22025678_ChIP-Seq_K562_Human1.73366175
20CTCF_27219007_Chip-Seq_Bcells_Human1.69362138
21EGR1_23403033_ChIP-Seq_LIVER_Mouse1.68659336
22YY1_22570637_ChIP-Seq_MALME-3M_Human1.67162829
23P53_21459846_ChIP-Seq_SAOS-2_Human1.66903475
24ERG_20517297_ChIP-Seq_VCAP_Human1.66742439
25RACK7_27058665_Chip-Seq_MCF-7_Human1.63455791
26BCOR_27268052_Chip-Seq_Bcells_Human1.60383289
27SOX9_24532713_ChIP-Seq_HFSC_Mouse1.58256912
28TP53_20018659_ChIP-ChIP_R1E_Mouse1.56583806
29TP63_22573176_ChIP-Seq_HFKS_Human1.55464128
30DNAJC2_21179169_ChIP-ChIP_NT2_Human1.55234104
31SCL_19346495_ChIP-Seq_HPC-7_Human1.47791298
32MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.47021731
33FOXO3_23340844_ChIP-Seq_DLD1_Human1.45221544
34UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.44201788
35PHF8_20622854_ChIP-Seq_HELA_Human1.43921703
36ATF3_27146783_Chip-Seq_COLON_Human1.41214101
37SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.39311612
38SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.39311612
39ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.39019365
40P68_20966046_ChIP-Seq_HELA_Human1.37984760
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.35912730
42ELF1_20517297_ChIP-Seq_JURKAT_Human1.35715687
43SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.32511819
44ESR1_21235772_ChIP-Seq_MCF-7_Human1.30516245
45ESR2_21235772_ChIP-Seq_MCF-7_Human1.27145609
46ESR1_20079471_ChIP-ChIP_T-47D_Human1.27118633
47KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.24678364
48E2F1_17053090_ChIP-ChIP_MCF-7_Human1.22917469
49KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22421452
50CEBPB_22108803_ChIP-Seq_LS180_Human1.21042190
51RAC3_21632823_ChIP-Seq_H3396_Human1.18631184
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.18583314
53AHR_22903824_ChIP-Seq_MCF-7_Human1.18061452
54ARNT_22903824_ChIP-Seq_MCF-7_Human1.17658261
55SMC4_20622854_ChIP-Seq_HELA_Human1.17402567
56PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.17057253
57IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16575553
58SA1_27219007_Chip-Seq_ERYTHROID_Human1.15761112
59SPI1_20517297_ChIP-Seq_HL60_Human1.15343998
60SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.15236367
61JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13678167
62RXRA_24833708_ChIP-Seq_LIVER_Mouse1.11192046
63P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10812801
64SUZ12_27294783_Chip-Seq_ESCs_Mouse1.09039298
65TRIM28_21343339_ChIP-Seq_HEK293_Human1.07830775
66GATA6_25053715_ChIP-Seq_YYC3_Human1.07514490
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.06695783
68GATA3_24758297_ChIP-Seq_MCF-7_Human1.05661117
69RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05569560
70EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05126194
71UBF1/2_26484160_Chip-Seq_HMECs_Human1.04887720
72RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03587945
73CDX2_20551321_ChIP-Seq_CACO-2_Human1.02921662
74SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01678377
75GATA4_25053715_ChIP-Seq_YYC3_Human1.01282637
76PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00557628
77EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99238749
78TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98993115
79SA1_27219007_Chip-Seq_Bcells_Human0.98949556
80TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97873390
81P300_27268052_Chip-Seq_Bcells_Human0.97859013
82FOXH1_21741376_ChIP-Seq_ESCs_Human0.97813123
83GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.97734082
84CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.93773855
85* TP63_23658742_ChIP-Seq_EP156T_Human0.93762459
86SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93459730
87ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93407705
88TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93226031
89* SOX2_21211035_ChIP-Seq_LN229_Human0.93149478
90STAT1_20625510_ChIP-Seq_HELA_Human0.92149225
91KLF5_25053715_ChIP-Seq_YYC3_Human0.91551590
92* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90989841
93NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.90866911
94RXR_22158963_ChIP-Seq_LIVER_Mouse0.90316883
95OCT4_20526341_ChIP-Seq_ESCs_Human0.89686937
96KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.89545851
97ELK3_25401928_ChIP-Seq_HUVEC_Human0.89493200
98JARID2_20075857_ChIP-Seq_MESCs_Mouse0.88665532
99GATA6_21074721_ChIP-Seq_CACO-2_Human0.88307365
100GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.88273436
101RUNX1_27514584_Chip-Seq_MCF-7_Human0.87745489
102PPARA_22158963_ChIP-Seq_LIVER_Mouse0.87315706
103ZFP281_18757296_ChIP-ChIP_E14_Mouse0.87149630
104ERA_21632823_ChIP-Seq_H3396_Human0.86168777
105MYC_19829295_ChIP-Seq_ESCs_Human0.83570767
106TP53_18474530_ChIP-ChIP_U2OS_Human0.82704401
107HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.82647158
108RING1B_27294783_Chip-Seq_ESCs_Mouse0.82596689
109RXR_22108803_ChIP-Seq_LS180_Human0.80588643
110ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.79694099
111TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.79509097
112RNF2_27304074_Chip-Seq_ESCs_Mouse0.78125484
113VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.77092147
114SOX2_20726797_ChIP-Seq_SW620_Human0.76860376
115EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.76191982
116FOXH1_21741376_ChIP-Seq_EPCs_Human0.76087602
117SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.75714987
118RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.75674188
119NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.75530610
120ZNF263_19887448_ChIP-Seq_K562_Human0.74989836
121* GATA3_21867929_ChIP-Seq_CD8_Mouse0.74436780
122FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.73836405
123SRY_22984422_ChIP-ChIP_TESTIS_Rat0.73479632
124GATA3_21878914_ChIP-Seq_MCF-7_Human0.73156678
125CTCF_21964334_ChIP-Seq_BJAB-B_Human0.72472466
126SMAD4_21741376_ChIP-Seq_ESCs_Human0.72293661
127* FOXA1_25329375_ChIP-Seq_VCAP_Human0.71724090
128* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.71724090
129JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.71290091
130CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.67440913
131CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.67106401

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology7.50971477
2MP0002098_abnormal_vibrissa_morphology7.48290565
3MP0000647_abnormal_sebaceous_gland6.55480083
4MP0002796_impaired_skin_barrier5.78417342
5MP0010234_abnormal_vibrissa_follicle5.32143792
6MP0005275_abnormal_skin_tensile4.97285490
7MP0000383_abnormal_hair_follicle4.44533940
8MP0000377_abnormal_hair_follicle4.14213857
9MP0010678_abnormal_skin_adnexa3.93144231
10MP0003705_abnormal_hypodermis_morpholog3.65953312
11MP0005501_abnormal_skin_physiology3.62338165
12MP0000427_abnormal_hair_cycle3.41934576
13MP0003878_abnormal_ear_physiology3.38201035
14MP0005377_hearing/vestibular/ear_phenot3.38201035
15MP0002254_reproductive_system_inflammat3.04842240
16MP0001216_abnormal_epidermal_layer2.62409524
17MP0004381_abnormal_hair_follicle2.52351119
18MP0000367_abnormal_coat/_hair2.47178116
19MP0004947_skin_inflammation2.33369308
20MP0003453_abnormal_keratinocyte_physiol2.26639069
21MP0010771_integument_phenotype2.25808368
22MP0001188_hyperpigmentation2.25427193
23MP0003195_calcinosis2.21409021
24MP0002060_abnormal_skin_morphology2.17289519
25MP0001243_abnormal_dermal_layer2.13587816
26MP0002234_abnormal_pharynx_morphology1.99267549
27MP0000467_abnormal_esophagus_morphology1.63990008
28MP0003303_peritoneal_inflammation1.57661930
29MP0009053_abnormal_anal_canal1.56020874
30MP0009931_abnormal_skin_appearance1.50685442
31MP0003866_abnormal_defecation1.46338938
32MP0000762_abnormal_tongue_morphology1.45496490
33MP0003566_abnormal_cell_adhesion1.44867691
34MP0002163_abnormal_gland_morphology1.35271302
35MP0003011_delayed_dark_adaptation1.23079045
36MP0003941_abnormal_skin_development1.14695988
37MP0005409_darkened_coat_color1.12295613
38MP0001191_abnormal_skin_condition0.96880201
39MP0010368_abnormal_lymphatic_system0.90867654
40MP0004885_abnormal_endolymph0.90444174
41MP0004185_abnormal_adipocyte_glucose0.87712118
42MP0004264_abnormal_extraembryonic_tissu0.87139045
43MP0001765_abnormal_ion_homeostasis0.84468349
44MP0002095_abnormal_skin_pigmentation0.83084107
45MP0005379_endocrine/exocrine_gland_phen0.81917723
46MP0001851_eye_inflammation0.78360502
47MP0008438_abnormal_cutaneous_collagen0.78217600
48MP0010030_abnormal_orbit_morphology0.71005265
49MP0003315_abnormal_perineum_morphology0.69205316
50MP0001340_abnormal_eyelid_morphology0.66456994
51MP0001485_abnormal_pinna_reflex0.66248896
52MP0004147_increased_porphyrin_level0.65335171
53MP0002877_abnormal_melanocyte_morpholog0.61720598
54MP0000858_altered_metastatic_potential0.61403508
55MP0001849_ear_inflammation0.59799243
56MP0006035_abnormal_mitochondrial_morpho0.58290276
57MP0003191_abnormal_cellular_cholesterol0.58105805
58MP0002138_abnormal_hepatobiliary_system0.57057395
59MP0001661_extended_life_span0.56861381
60MP0005174_abnormal_tail_pigmentation0.56843754
61MP0000627_abnormal_mammary_gland0.56816967
62MP0001346_abnormal_lacrimal_gland0.56583113
63MP0000371_diluted_coat_color0.55634440
64MP0002282_abnormal_trachea_morphology0.53427715
65MP0005023_abnormal_wound_healing0.53255463
66MP0005647_abnormal_sex_gland0.51147645
67MP0002970_abnormal_white_adipose0.49773679
68MP0000566_synostosis0.48917168
69MP0000613_abnormal_salivary_gland0.48616300
70MP0003763_abnormal_thymus_physiology0.48369369
71MP0005075_abnormal_melanosome_morpholog0.48194367
72MP0003755_abnormal_palate_morphology0.47321676
73MP0001919_abnormal_reproductive_system0.44594240
74MP0005451_abnormal_body_composition0.43389512
75MP0001784_abnormal_fluid_regulation0.43171149
76MP0009780_abnormal_chondrocyte_physiolo0.42750068
77MP0002111_abnormal_tail_morphology0.42665183
78MP0002249_abnormal_larynx_morphology0.42193784
79MP0010155_abnormal_intestine_physiology0.40242554
80MP0010352_gastrointestinal_tract_polyps0.39329725
81MP0004782_abnormal_surfactant_physiolog0.36889734
82MP0002653_abnormal_ependyma_morphology0.36856365
83MP0009840_abnormal_foam_cell0.36363841
84MP0002075_abnormal_coat/hair_pigmentati0.36175059
85MP0001764_abnormal_homeostasis0.36012926
86MP0005000_abnormal_immune_tolerance0.35295394
87MP0005408_hypopigmentation0.32865931
88MP0000003_abnormal_adipose_tissue0.32351463
89MP0000678_abnormal_parathyroid_gland0.31670293
90MP0000358_abnormal_cell_content/0.30547520
91MP0002166_altered_tumor_susceptibility0.28988086
92MP0003329_amyloid_beta_deposits0.28596574
93MP0003385_abnormal_body_wall0.28311938
94MP0005084_abnormal_gallbladder_morpholo0.27818456
95MP0001873_stomach_inflammation0.26358369
96MP0002177_abnormal_outer_ear0.25801700
97MP0000537_abnormal_urethra_morphology0.25659829
98MP0001186_pigmentation_phenotype0.25261738
99MP0000477_abnormal_intestine_morphology0.24890827
100MP0002006_tumorigenesis0.24375091
101MP0000465_gastrointestinal_hemorrhage0.24221887
102MP0001664_abnormal_digestion0.24019283
103MP0009379_abnormal_foot_pigmentation0.23760772
104MP0003638_abnormal_response/metabolism_0.22648601
105MP0004272_abnormal_basement_membrane0.22552226
106MP0002697_abnormal_eye_size0.22326686
107MP0000685_abnormal_immune_system0.21593125
108MP0003448_altered_tumor_morphology0.21113616
109MP0004019_abnormal_vitamin_homeostasis0.20795062
110MP0005083_abnormal_biliary_tract0.20182873
111MP0005248_abnormal_Harderian_gland0.19724306
112MP0005167_abnormal_blood-brain_barrier0.19712232
113MP0009785_altered_susceptibility_to0.18836700
114MP0003075_altered_response_to0.17918395
115MP0000609_abnormal_liver_physiology0.17813894
116MP0003950_abnormal_plasma_membrane0.17522765
117MP0009333_abnormal_splenocyte_physiolog0.17365855
118MP0003300_gastrointestinal_ulcer0.17012913
119MP0000432_abnormal_head_morphology0.16552343
120MP0000604_amyloidosis0.16122254
121MP0005076_abnormal_cell_differentiation0.16113418
122MP0003935_abnormal_craniofacial_develop0.13822945
123MP0003045_fibrosis0.13610834
124MP0003436_decreased_susceptibility_to0.13386311
125MP0002009_preneoplasia0.12759986
126MP0006054_spinal_hemorrhage0.12186391
127MP0005666_abnormal_adipose_tissue0.11862086
128MP0004858_abnormal_nervous_system0.10898585
129MP0000343_altered_response_to0.10497876
130MP0004742_abnormal_vestibular_system0.10030666
131MP0005375_adipose_tissue_phenotype0.09959420
132MP0005165_increased_susceptibility_to0.09352923
133MP0001879_abnormal_lymphatic_vessel0.07762678
134MP0001958_emphysema0.07407927
135MP0005367_renal/urinary_system_phenotyp0.07384659
136MP0000516_abnormal_urinary_system0.07384659
137MP0002909_abnormal_adrenal_gland0.06836408
138MP0000462_abnormal_digestive_system0.06752058
139MP0001348_abnormal_lacrimal_gland0.06417608
140MP0005193_abnormal_anterior_eye0.06373539
141MP0001730_embryonic_growth_arrest0.05853134

Predicted human phenotypes

RankGene SetZ-score
1Pili torti (HP:0003777)9.33118365
2* Brittle hair (HP:0002299)9.08217394
3* Nail dystrophy (HP:0008404)6.92623328
4Absent eyebrow (HP:0002223)6.09462719
5Abnormality of nail color (HP:0100643)5.97274284
6Abnormal hair laboratory examination (HP:0003328)5.90444536
7Retrobulbar optic neuritis (HP:0100654)5.88595065
8Optic neuritis (HP:0100653)5.88595065
9Fragile nails (HP:0001808)5.82585737
10Orchitis (HP:0100796)5.41532842
11Alopecia of scalp (HP:0002293)5.18937790
12* Fine hair (HP:0002213)4.94423445
13Palmoplantar hyperkeratosis (HP:0000972)4.89553693
14Absent hair (HP:0002298)4.79518015
15Onycholysis (HP:0001806)4.72270170
16Palmar hyperkeratosis (HP:0010765)4.59952465
17Plantar hyperkeratosis (HP:0007556)4.45367125
18Increased IgE level (HP:0003212)4.39194914
19Thick nail (HP:0001805)4.37612097
20Myositis (HP:0100614)4.27864320
21Right ventricular cardiomyopathy (HP:0011663)4.17387125
22Follicular hyperkeratosis (HP:0007502)4.14667422
23Sparse eyelashes (HP:0000653)3.65454776
24Erythema (HP:0010783)3.55376192
25Amelogenesis imperfecta (HP:0000705)3.39269658
26Abnormality of the frontal sinuses (HP:0002687)3.31422997
27Milia (HP:0001056)3.26353049
28Oral leukoplakia (HP:0002745)3.22558886
29Parakeratosis (HP:0001036)3.11912381
30Hypophosphatemic rickets (HP:0004912)3.11472465
31Abnormality of the axillary hair (HP:0100134)3.04496491
32Abnormality of secondary sexual hair (HP:0009888)3.04496491
33Erythroderma (HP:0001019)3.01032181
34Curly hair (HP:0002212)2.86181184
35Intention tremor (HP:0002080)2.75818676
36Congenital ichthyosiform erythroderma (HP:0007431)2.72528480
37Ridged nail (HP:0001807)2.72148625
38Neck muscle weakness (HP:0000467)2.68617374
39Congenital, generalized hypertrichosis (HP:0004540)2.67891757
40Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.59796876
41Dry hair (HP:0011359)2.57895384
42Aplasia cutis congenita (HP:0001057)2.54258924
43Torticollis (HP:0000473)2.49643214
44Abnormal blistering of the skin (HP:0008066)2.39092845
45Natal tooth (HP:0000695)2.36707801
46Concave nail (HP:0001598)2.30342220
47Advanced eruption of teeth (HP:0006288)2.27615008
48Corneal erosion (HP:0200020)2.22993235
49Hypohidrosis (HP:0000966)2.16584859
50Craniofacial dystonia (HP:0012179)2.12201504
51Palmoplantar keratoderma (HP:0000982)2.05629714
52Abnormality of the pupil (HP:0000615)2.04868293
53Ventricular tachycardia (HP:0004756)2.04052307
54Difficulty walking (HP:0002355)2.02251123
55Pruritus (HP:0000989)2.01668856
56Arterial thrombosis (HP:0004420)2.00744100
57* Hypotrichosis (HP:0001006)14.2079297
58Woolly hair (HP:0002224)11.7368823
59* Abnormality of hair growth rate (HP:0011363)10.5478886
60* Slow-growing hair (HP:0002217)10.5478886
61Focal dystonia (HP:0004373)1.93677237
62Abnormality of the parietal bone (HP:0002696)1.93361193
63Abnormality of dental color (HP:0011073)1.90309404
64Keratitis (HP:0000491)1.84079090
65Coarse hair (HP:0002208)1.83687548
66Widely patent fontanelles and sutures (HP:0004492)1.81408569
67Abnormality of permanent molar morphology (HP:0011071)1.80374598
68Abnormality of the dental root (HP:0006486)1.80374598
69Taurodontia (HP:0000679)1.80374598
70Vertigo (HP:0002321)1.77895103
71Abnormality of molar (HP:0011077)1.77707821
72Abnormality of molar morphology (HP:0011070)1.77707821
73Vascular calcification (HP:0004934)1.76519706
74Fatigable weakness (HP:0003473)1.75723924
75Abnormality of the neuromuscular junction (HP:0003398)1.75723924
76Abnormality of the aortic arch (HP:0012303)1.73645939
77Anorexia (HP:0002039)1.72801407
78Ventricular fibrillation (HP:0001663)1.72692329
79Rickets (HP:0002748)1.70107658
80Eczematoid dermatitis (HP:0000976)1.68422208
81Hyporeflexia of lower limbs (HP:0002600)1.68110396
82Abnormality of placental membranes (HP:0011409)1.66538274
83Amniotic constriction ring (HP:0009775)1.66538274
84Absent eyelashes (HP:0000561)1.64406544
85Persistence of primary teeth (HP:0006335)1.63257332
86Unilateral renal agenesis (HP:0000122)1.62925483
87Recurrent corneal erosions (HP:0000495)1.61550739
88Esophageal neoplasm (HP:0100751)1.57932706
89Neoplasm of head and neck (HP:0012288)1.57932706
90Acanthosis nigricans (HP:0000956)1.57298177
91Abnormality of the dental pulp (HP:0006479)1.57181761
92Keratoconjunctivitis sicca (HP:0001097)1.57029414
93Acne (HP:0001061)1.56843446
94Blepharitis (HP:0000498)1.56317676
95Sudden death (HP:0001699)1.56056097
96Thyroid-stimulating hormone excess (HP:0002925)1.55943650
97Hamartoma of the eye (HP:0010568)1.54966699
98Achilles tendon contracture (HP:0001771)1.50338890
99Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.50156825
100Cardiovascular calcification (HP:0011915)1.50150798
101Abnormality of intracranial pressure (HP:0012640)1.48490912
102Increased intracranial pressure (HP:0002516)1.48490912
103Gangrene (HP:0100758)1.47548230
104Hypergammaglobulinemia (HP:0010702)1.47319803
105Conjunctival hamartoma (HP:0100780)1.46782297
106Pulmonary infiltrates (HP:0002113)1.45850047
107Polyneuropathy (HP:0001271)1.45314141
108Distal lower limb muscle weakness (HP:0009053)1.45286943
109Encephalitis (HP:0002383)1.45090369
110Selective tooth agenesis (HP:0001592)1.42313883
111Flat capital femoral epiphysis (HP:0003370)1.42006806
112Premature loss of primary teeth (HP:0006323)1.41756938
113Lip pit (HP:0100267)1.41709903
114Abnormality of the Achilles tendon (HP:0005109)1.41379035
115Carious teeth (HP:0000670)1.39696570
116Ectropion (HP:0000656)1.39679891
117Keratoconjunctivitis (HP:0001096)1.38447906
118Urticaria (HP:0001025)1.37242896
119Ileus (HP:0002595)1.37072800
120Craniofacial hyperostosis (HP:0004493)1.36329638
121Round ear (HP:0100830)1.35590328
122Hypophosphatemia (HP:0002148)1.35072450
123Male infertility (HP:0003251)1.34754155
124Hemoptysis (HP:0002105)1.33423972
125Abnormality of the fingernails (HP:0001231)1.32045437
126Abnormality of the distal phalanges of the toes (HP:0010182)1.31267032
127Autoamputation (HP:0001218)1.29733679
128Adactyly (HP:0009776)1.28929389
129Furrowed tongue (HP:0000221)1.28864862
130Lack of skin elasticity (HP:0100679)1.28677827
131Neonatal onset (HP:0003623)1.28400040
132Aseptic necrosis (HP:0010885)1.27625319
133Melanocytic nevus (HP:0000995)1.26932227
134Anonychia (HP:0001798)1.26505577
135Myocardial infarction (HP:0001658)1.25477960
136Glomerulopathy (HP:0100820)1.25086643
137Sparse scalp hair (HP:0002209)1.23460663
138Ankle clonus (HP:0011448)1.20331406
139Atrophic scars (HP:0001075)1.19458884
140Wide cranial sutures (HP:0010537)1.19022046
141Widely spaced teeth (HP:0000687)1.18989584
142Thrombophlebitis (HP:0004418)1.18936514
143Bronchomalacia (HP:0002780)1.18098039
144* Heterogeneous (HP:0001425)1.16798155
145Increased connective tissue (HP:0009025)1.16743240
146Recurrent bacterial skin infections (HP:0005406)1.16681860
147Abnormality of the pericardium (HP:0001697)1.16286906
148Type 1 muscle fiber predominance (HP:0003803)1.16239841
149Interstitial pulmonary disease (HP:0006530)1.14255949
150Pulmonary embolism (HP:0002204)1.14136512

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA36.44522706
2SIK35.11671085
3EPHA24.24753343
4MAP3K64.11286868
5MAPKAPK34.08355129
6ERN14.01990036
7FER3.53435699
8LMTK23.38914663
9TAOK12.96259486
10EPHB22.78366692
11MAP3K112.74980814
12MAP3K32.73007924
13TRIB32.71887154
14ARAF2.56817028
15TIE12.37179199
16IRAK12.25411032
17ZAK2.11708125
18BRD42.11257327
19MAP3K22.10554478
20LATS12.03165403
21RPS6KB21.94078796
22MAP2K61.82203700
23MUSK1.72887531
24TTN1.61958152
25STK391.60769183
26EPHB11.60357243
27BLK1.57437033
28LATS21.56769583
29EEF2K1.55280724
30PIK3CG1.54555264
31CHUK1.50922840
32IKBKB1.48886399
33MAPK111.48784469
34NLK1.47751702
35BMX1.42153767
36OXSR11.31800949
37FGFR41.28930147
38NME11.28232875
39CDK61.24087801
40MAP2K31.22833945
41DDR21.22553163
42MAP3K11.21553715
43PDGFRA1.14533100
44SIK21.12745531
45FGFR11.11161558
46TLK11.09759633
47FGFR21.08910876
48PIM21.08078956
49RIPK11.06801059
50MAPKAPK21.06404049
51TESK21.05585746
52PKN21.04423418
53KSR21.03705157
54TRIM281.02676466
55TXK1.01244705
56DYRK1B1.00543139
57LRRK20.99915107
58TESK10.98570941
59BCR0.98543370
60PTK20.94138587
61MAP4K10.92280541
62ICK0.90869806
63SIK10.88557628
64PIK3CA0.88435877
65TYRO30.88090548
66FGFR30.87342166
67MST1R0.84341733
68PAK40.83996155
69MAP3K70.83769270
70PTK60.82721031
71MAP3K90.80642728
72SMG10.80073103
73PBK0.78887975
74STK380.76543472
75JAK10.73918809
76RPS6KA40.70200477
77PRKD10.68975101
78TRPM70.68033408
79MAP3K100.64577076
80MAP2K40.62745010
81MAP2K10.61489758
82VRK10.59635081
83RPS6KA50.56731368
84PRKCE0.56716754
85BCKDK0.56699489
86CSK0.55999439
87CDK190.54987906
88GRK60.54578482
89ROCK10.54446877
90PRKCH0.53768359
91MATK0.53609088
92MARK30.53235620
93HIPK20.52948980
94MAP3K50.52590671
95TAOK30.52532117
96STK38L0.52395921
97LIMK10.52060481
98PAK30.51912568
99FGR0.49508421
100CSNK1A1L0.49450909
101RPS6KA10.49326684
102GSK3A0.49130936
103TYK20.48466370
104ALK0.48063404
105MAP3K120.47751060
106PRKCI0.47590813
107KIT0.47572673
108GRK10.47184978
109MET0.47043780
110ERBB40.46050181
111NTRK20.44958219
112SCYL20.44242280
113ILK0.43692444
114NME20.43317932
115MARK20.42835614
116JAK20.42301430
117HCK0.41469093
118IRAK30.41192594
119MST40.40686682
120PAK60.38993724
121PAK20.38582570
122ZAP700.37895527
123MAP2K20.37190499
124STK30.35236554
125MAPK120.34385469
126TGFBR10.33562944
127RET0.32892812
128FYN0.32772625
129ERBB30.32365785
130CSNK1E0.32266916
131CLK10.31860493
132MYLK0.30562490
133ERBB20.30104388
134UHMK10.29757913
135CDC42BPA0.28888283
136PHKG10.28218372
137PHKG20.28218372
138BRAF0.28026307
139KDR0.27791241
140CSNK1G30.27693856
141MAP3K80.27440218
142NEK10.26144083
143PRKCD0.23435081
144PRKCQ0.23339074
145RPS6KA20.23016466
146MAPK90.18959178
147IKBKE0.18846719
148MAPKAPK50.17560821
149NEK60.17180072
150FES0.17031895
151STK240.15505347
152RAF10.14297600
153MAPK80.14156226
154CAMK2G0.13318324
155CSNK1A10.13311721
156PRKD20.12654194
157PDK10.08808444

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005925.19690973
2Linoleic acid metabolism_Homo sapiens_hsa005915.17339277
3Vitamin digestion and absorption_Homo sapiens_hsa049774.29290425
4Pantothenate and CoA biosynthesis_Homo sapiens_hsa007703.80085894
5Fat digestion and absorption_Homo sapiens_hsa049753.39437678
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.89007102
7Ether lipid metabolism_Homo sapiens_hsa005652.73654494
8Fatty acid elongation_Homo sapiens_hsa000622.70927293
9Basal cell carcinoma_Homo sapiens_hsa052172.19025761
10VEGF signaling pathway_Homo sapiens_hsa043701.99751923
11Arachidonic acid metabolism_Homo sapiens_hsa005901.96244555
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.89106150
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.72553849
14Phenylalanine metabolism_Homo sapiens_hsa003601.72536809
15Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.64111350
16Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.61039801
17Sphingolipid metabolism_Homo sapiens_hsa006001.57081170
18Bladder cancer_Homo sapiens_hsa052191.53483525
19Melanogenesis_Homo sapiens_hsa049161.50306782
20Axon guidance_Homo sapiens_hsa043601.47970345
21Glycerolipid metabolism_Homo sapiens_hsa005611.47007829
22Hedgehog signaling pathway_Homo sapiens_hsa043401.42030092
23Thyroid cancer_Homo sapiens_hsa052161.39966832
24Retinol metabolism_Homo sapiens_hsa008301.38834384
25Histidine metabolism_Homo sapiens_hsa003401.37992624
26Hippo signaling pathway_Homo sapiens_hsa043901.31828130
27Vascular smooth muscle contraction_Homo sapiens_hsa042701.30345820
28Adipocytokine signaling pathway_Homo sapiens_hsa049201.27307474
29Acute myeloid leukemia_Homo sapiens_hsa052211.26314082
30Proteoglycans in cancer_Homo sapiens_hsa052051.25572051
31Glioma_Homo sapiens_hsa052141.25190673
32Caffeine metabolism_Homo sapiens_hsa002321.21766966
33GnRH signaling pathway_Homo sapiens_hsa049121.15042006
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.12827572
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11292819
36Pancreatic secretion_Homo sapiens_hsa049721.07040162
37Tight junction_Homo sapiens_hsa045301.06930177
38Ovarian steroidogenesis_Homo sapiens_hsa049131.05588378
39Mineral absorption_Homo sapiens_hsa049781.03240522
40Glycerophospholipid metabolism_Homo sapiens_hsa005641.02765550
41Adherens junction_Homo sapiens_hsa045201.00358387
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.98803934
43Staphylococcus aureus infection_Homo sapiens_hsa051500.97458297
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95718703
45Steroid biosynthesis_Homo sapiens_hsa001000.95576558
46Long-term potentiation_Homo sapiens_hsa047200.94225407
47PPAR signaling pathway_Homo sapiens_hsa033200.93045806
48Steroid hormone biosynthesis_Homo sapiens_hsa001400.91444034
49Leukocyte transendothelial migration_Homo sapiens_hsa046700.90294395
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90000647
51Dorso-ventral axis formation_Homo sapiens_hsa043200.88850149
52Vibrio cholerae infection_Homo sapiens_hsa051100.88004912
53Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87923804
54Pertussis_Homo sapiens_hsa051330.87605979
55Jak-STAT signaling pathway_Homo sapiens_hsa046300.86472368
56Non-small cell lung cancer_Homo sapiens_hsa052230.84365269
57Ras signaling pathway_Homo sapiens_hsa040140.84102610
58ECM-receptor interaction_Homo sapiens_hsa045120.83708549
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82263326
60Galactose metabolism_Homo sapiens_hsa000520.80877918
61Nitrogen metabolism_Homo sapiens_hsa009100.80221024
62Endometrial cancer_Homo sapiens_hsa052130.80176265
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79732710
64Estrogen signaling pathway_Homo sapiens_hsa049150.79540038
65Wnt signaling pathway_Homo sapiens_hsa043100.79006788
66Tyrosine metabolism_Homo sapiens_hsa003500.78666973
67beta-Alanine metabolism_Homo sapiens_hsa004100.76115274
68Long-term depression_Homo sapiens_hsa047300.72505589
69B cell receptor signaling pathway_Homo sapiens_hsa046620.70650106
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.70158555
71Fatty acid metabolism_Homo sapiens_hsa012120.68780830
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68544975
73Fatty acid biosynthesis_Homo sapiens_hsa000610.67178050
74Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66550168
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.66310825
76Salmonella infection_Homo sapiens_hsa051320.66219877
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66134571
78Amoebiasis_Homo sapiens_hsa051460.65716791
79Pancreatic cancer_Homo sapiens_hsa052120.65067027
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63121337
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61829511
82Rap1 signaling pathway_Homo sapiens_hsa040150.60680807
83MicroRNAs in cancer_Homo sapiens_hsa052060.60651501
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.59839987
85Thyroid hormone synthesis_Homo sapiens_hsa049180.59713406
86Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.58910921
87p53 signaling pathway_Homo sapiens_hsa041150.57693276
88Fructose and mannose metabolism_Homo sapiens_hsa000510.57403171
89Hepatitis C_Homo sapiens_hsa051600.57015297
90Gap junction_Homo sapiens_hsa045400.54906560
91Insulin resistance_Homo sapiens_hsa049310.54068063
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53503498
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.53441731
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52526428
95Gastric acid secretion_Homo sapiens_hsa049710.51317141
96Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51247219
97Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50513614
98Focal adhesion_Homo sapiens_hsa045100.50503810
99ABC transporters_Homo sapiens_hsa020100.50201385
100Notch signaling pathway_Homo sapiens_hsa043300.49340315
101Renin secretion_Homo sapiens_hsa049240.49023520
102Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48793324
103Shigellosis_Homo sapiens_hsa051310.48566503
104Platelet activation_Homo sapiens_hsa046110.48528938
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.48370998
106Small cell lung cancer_Homo sapiens_hsa052220.46825401
107TGF-beta signaling pathway_Homo sapiens_hsa043500.46705688
108N-Glycan biosynthesis_Homo sapiens_hsa005100.46147396
109NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44729134
110Tuberculosis_Homo sapiens_hsa051520.43835917
111ErbB signaling pathway_Homo sapiens_hsa040120.43479374
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43228662
113Chronic myeloid leukemia_Homo sapiens_hsa052200.42504192
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41279740
115Phototransduction_Homo sapiens_hsa047440.41238120
116Prolactin signaling pathway_Homo sapiens_hsa049170.40517767
117Collecting duct acid secretion_Homo sapiens_hsa049660.39606152
118Endocytosis_Homo sapiens_hsa041440.39410817
119Oxytocin signaling pathway_Homo sapiens_hsa049210.38785347
120Bile secretion_Homo sapiens_hsa049760.38648774
121Toxoplasmosis_Homo sapiens_hsa051450.38558470
122T cell receptor signaling pathway_Homo sapiens_hsa046600.38060820
123Fatty acid degradation_Homo sapiens_hsa000710.37768113
124Renal cell carcinoma_Homo sapiens_hsa052110.37379103
125Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.36908230
126Carbon metabolism_Homo sapiens_hsa012000.36851389
127Amphetamine addiction_Homo sapiens_hsa050310.36216397
128Lysosome_Homo sapiens_hsa041420.36146405
129Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35570721
130Insulin signaling pathway_Homo sapiens_hsa049100.35045720
131Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34926185
132Prion diseases_Homo sapiens_hsa050200.34893694
133Butanoate metabolism_Homo sapiens_hsa006500.33823772
134Protein digestion and absorption_Homo sapiens_hsa049740.33561676
135Chemical carcinogenesis_Homo sapiens_hsa052040.32724544
136Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32678065
137Hepatitis B_Homo sapiens_hsa051610.32497673
138Salivary secretion_Homo sapiens_hsa049700.32452189
139Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.32225700
140Viral carcinogenesis_Homo sapiens_hsa052030.30957958
141Peroxisome_Homo sapiens_hsa041460.30371645
142Olfactory transduction_Homo sapiens_hsa047400.29686156
143Choline metabolism in cancer_Homo sapiens_hsa052310.27762355
144Sulfur metabolism_Homo sapiens_hsa009200.27706631
145Apoptosis_Homo sapiens_hsa042100.26791774
146Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.25709116
147Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24416452

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