KRT8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1bundle of His cell to Purkinje myocyte communication (GO:0086069)7.37119654
2regulation of branching involved in prostate gland morphogenesis (GO:0060687)6.25086272
3intestinal epithelial cell development (GO:0060576)6.05702366
4positive regulation of keratinocyte differentiation (GO:0045618)5.64538879
5interferon-gamma secretion (GO:0072643)5.64404056
6hemidesmosome assembly (GO:0031581)5.60138808
7intestinal absorption (GO:0050892)5.47423283
8regulation of cell proliferation involved in kidney development (GO:1901722)5.23618610
9calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.95141783
10intestinal cholesterol absorption (GO:0030299)4.81211016
11ear development (GO:0043583)4.80286289
12maintenance of gastrointestinal epithelium (GO:0030277)4.75031836
13positive regulation of epidermal cell differentiation (GO:0045606)4.71114510
14desmosome organization (GO:0002934)4.57149498
15* hepatocyte apoptotic process (GO:0097284)4.56832809
16UDP-N-acetylglucosamine metabolic process (GO:0006047)4.45100629
17branching involved in mammary gland duct morphogenesis (GO:0060444)4.29593128
18sulfur amino acid catabolic process (GO:0000098)4.29121483
19glucose 6-phosphate metabolic process (GO:0051156)4.23598166
20tight junction assembly (GO:0070830)4.17878067
21regulation of cell-cell adhesion mediated by cadherin (GO:2000047)4.13684464
22regulation of cholesterol homeostasis (GO:2000188)4.12875777
23mesonephros development (GO:0001823)4.11184315
24epithelial cell-cell adhesion (GO:0090136)3.98184967
25vagina development (GO:0060068)3.90744993
26response to food (GO:0032094)3.87901213
27epithelial structure maintenance (GO:0010669)3.87559057
28trophectodermal cell differentiation (GO:0001829)3.85145987
29proline biosynthetic process (GO:0006561)3.82667173
30striated muscle atrophy (GO:0014891)3.81476082
31norepinephrine metabolic process (GO:0042415)3.77866867
32activation of Rac GTPase activity (GO:0032863)3.73899439
33bile acid and bile salt transport (GO:0015721)3.73458223
34retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.70963247
35negative regulation of cell size (GO:0045792)3.70804072
36regulation of water loss via skin (GO:0033561)3.66935701
37glucose catabolic process (GO:0006007)3.65743357
38embryonic eye morphogenesis (GO:0048048)3.61669037
39nephron tubule formation (GO:0072079)3.59218324
40positive regulation of pseudopodium assembly (GO:0031274)3.56045265
41regulation of keratinocyte differentiation (GO:0045616)3.48870870
42negative regulation of kidney development (GO:0090185)3.48638050
43maternal placenta development (GO:0001893)3.48231720
44O-glycan processing (GO:0016266)3.45829056
45negative regulation of keratinocyte proliferation (GO:0010839)3.45265607
463-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.44350086
47purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.44350086
48protein retention in ER lumen (GO:0006621)3.44080652
49embryonic camera-type eye morphogenesis (GO:0048596)3.43580941
50galactose catabolic process (GO:0019388)3.40256634
51cardiac right ventricle morphogenesis (GO:0003215)3.39890814
52mesodermal cell differentiation (GO:0048333)3.38475123
53protein autoprocessing (GO:0016540)3.38007085
54digestive system process (GO:0022600)3.36069602
55muscle atrophy (GO:0014889)3.36060422
56skeletal muscle adaptation (GO:0043501)3.36050727
57COPI coating of Golgi vesicle (GO:0048205)3.35837662
58Golgi transport vesicle coating (GO:0048200)3.35837662
59flavonoid metabolic process (GO:0009812)3.32044647
60positive regulation of establishment of protein localization to plasma membrane (GO:0090004)3.31477307
61regulation of mammary gland epithelial cell proliferation (GO:0033599)3.29674780
62regulation of histone H3-K27 methylation (GO:0061085)3.29214939
63positive regulation of epidermis development (GO:0045684)3.27973013
64regulation of apoptotic process involved in morphogenesis (GO:1902337)3.22694011
65actin filament depolymerization (GO:0030042)3.22670289
66focal adhesion assembly (GO:0048041)3.21090603
67cell-substrate adherens junction assembly (GO:0007045)3.21090603
68ventricular cardiac muscle cell action potential (GO:0086005)3.16539243
69negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.15726320
70amyloid precursor protein metabolic process (GO:0042982)3.13511010
71regulation of bile acid biosynthetic process (GO:0070857)3.13266022
72regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.12576146
73positive regulation of cellular amine metabolic process (GO:0033240)3.12050572
74regulation of centriole replication (GO:0046599)3.11841143
75positive regulation of protein localization to plasma membrane (GO:1903078)3.10721770
76dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.09979540
77peptidyl-arginine omega-N-methylation (GO:0035247)3.09316688
78regulation of fatty acid beta-oxidation (GO:0031998)3.08735296
79positive regulation of actin filament depolymerization (GO:0030836)3.08663747
80cytoskeletal anchoring at plasma membrane (GO:0007016)3.07813516
81nucleotide-sugar biosynthetic process (GO:0009226)3.04850238
82amyloid precursor protein catabolic process (GO:0042987)3.04800772
83uterus development (GO:0060065)3.03848933
84regulation of pseudopodium assembly (GO:0031272)3.03805767
85embryonic skeletal joint morphogenesis (GO:0060272)3.03087686
86signal transduction involved in regulation of gene expression (GO:0023019)3.02128725
87lung epithelium development (GO:0060428)2.99451270
88regulation of establishment or maintenance of cell polarity (GO:0032878)2.98759341
89adherens junction assembly (GO:0034333)2.96757331
90biotin metabolic process (GO:0006768)2.96601024
91vitamin transmembrane transport (GO:0035461)2.94393988
92regulation of cholesterol biosynthetic process (GO:0045540)2.94101015
93ER overload response (GO:0006983)2.93246903
94regulation of hippo signaling (GO:0035330)2.92748228
95membrane budding (GO:0006900)2.92427748
96NADH metabolic process (GO:0006734)2.92390754
97post-embryonic morphogenesis (GO:0009886)2.92385045
98transcytosis (GO:0045056)2.92250932
99pyrimidine-containing compound transmembrane transport (GO:0072531)2.91397213
100cell proliferation involved in metanephros development (GO:0072203)2.91379021
101regulation of interleukin-13 production (GO:0032656)2.90631696
102female genitalia development (GO:0030540)2.90317369
103respiratory tube development (GO:0030323)2.89563313
104lung morphogenesis (GO:0060425)2.88443177
105skin morphogenesis (GO:0043589)2.86749333
106negative regulation of sterol transport (GO:0032372)2.85938851
107negative regulation of cholesterol transport (GO:0032375)2.85938851
108pentose metabolic process (GO:0019321)2.85513036
109spliceosomal tri-snRNP complex assembly (GO:0000244)2.85013815
110regulation of cardioblast differentiation (GO:0051890)2.84630494
111regulation of establishment of cell polarity (GO:2000114)2.82550547
112glandular epithelial cell differentiation (GO:0002067)2.81324533
113nitric oxide biosynthetic process (GO:0006809)2.80054311
114primary alcohol catabolic process (GO:0034310)2.80011152
115regulation of glucose import in response to insulin stimulus (GO:2001273)2.78710622
116phospholipid homeostasis (GO:0055091)2.77350432
117cell-cell junction assembly (GO:0007043)2.76714217
118sulfate transmembrane transport (GO:1902358)2.76063151
119cysteine metabolic process (GO:0006534)2.74498881
120establishment of apical/basal cell polarity (GO:0035089)2.74412884
121positive regulation of glycoprotein metabolic process (GO:1903020)2.73293363
122phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.72223615
123GDP-mannose metabolic process (GO:0019673)2.72145476
124positive regulation of hormone metabolic process (GO:0032352)2.71451616
125negative regulation of cell fate specification (GO:0009996)2.69381475
126vitamin A metabolic process (GO:0006776)2.69224535
127modified amino acid transport (GO:0072337)2.68969203
128semaphorin-plexin signaling pathway (GO:0071526)2.68446675
129pentose-phosphate shunt (GO:0006098)2.67671032
130negative regulation of organelle assembly (GO:1902116)2.67493546
131cell adhesion mediated by integrin (GO:0033627)2.67147168
132lipoprotein metabolic process (GO:0042157)2.66169327
133angiotensin maturation (GO:0002003)2.65520159
134establishment of skin barrier (GO:0061436)2.65186537
135cellular glucuronidation (GO:0052695)2.64868614
136regulation of podosome assembly (GO:0071801)2.64202928
137negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.63784080
138embryonic foregut morphogenesis (GO:0048617)2.63621717
139lung secretory cell differentiation (GO:0061140)2.63273887
140* cell differentiation involved in embryonic placenta development (GO:0060706)2.62908447
141regulation of chemokine secretion (GO:0090196)2.62233112
142ethanol metabolic process (GO:0006067)2.61382007
143glutathione derivative biosynthetic process (GO:1901687)2.60775613
144glutathione derivative metabolic process (GO:1901685)2.60775613
145vitamin transport (GO:0051180)2.60605677
146maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.57998802
147diterpenoid biosynthetic process (GO:0016102)2.57270667
148sulfur compound transport (GO:0072348)2.57063379
149regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.56791675
150lung vasculature development (GO:0060426)2.56549736
151proline metabolic process (GO:0006560)2.56356395
152gap junction assembly (GO:0016264)2.56182323
153positive regulation of fatty acid beta-oxidation (GO:0032000)2.55334357
154epithelial cell differentiation involved in prostate gland development (GO:0060742)2.55274750
155TOR signaling (GO:0031929)2.55274156
156face development (GO:0060324)2.55102253
157maternal process involved in female pregnancy (GO:0060135)2.54864669
158L-ascorbic acid metabolic process (GO:0019852)2.54394445
159multicellular organismal water homeostasis (GO:0050891)2.54283040
160NADPH regeneration (GO:0006740)2.53776494
161cell migration involved in gastrulation (GO:0042074)2.53677683
162regulation of proton transport (GO:0010155)2.53479652
163regulation of Cdc42 GTPase activity (GO:0043088)2.53449961
164hypotonic response (GO:0006971)2.52944284
165morphogenesis of embryonic epithelium (GO:0016331)2.52711505
166nucleoside diphosphate biosynthetic process (GO:0009133)2.52312674
167positive regulation of Cdc42 GTPase activity (GO:0043089)2.52099736
168branching involved in salivary gland morphogenesis (GO:0060445)2.51872083
169thyroid hormone metabolic process (GO:0042403)2.51167674
170peptidyl-arginine methylation (GO:0018216)2.51074998
171peptidyl-arginine N-methylation (GO:0035246)2.51074998
172mammary gland alveolus development (GO:0060749)2.50822040
173regulation of epidermal cell differentiation (GO:0045604)2.50626626
174cellular zinc ion homeostasis (GO:0006882)2.50410437
175urea cycle (GO:0000050)2.49963405
176adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.49903889
177endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.49714093

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.67158435
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.58828084
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.48980927
4SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.19389524
5* CDX2_20551321_ChIP-Seq_CACO-2_Human3.15178132
6* SOX2_27498859_Chip-Seq_STOMACH_Mouse3.12237811
7* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.91181928
8RXR_22158963_ChIP-Seq_LIVER_Mouse2.70843564
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.59039380
10* GATA4_25053715_ChIP-Seq_YYC3_Human2.58713010
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.51310940
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.51162893
13* GATA6_25053715_ChIP-Seq_YYC3_Human2.49353910
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.43612076
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.42528358
16* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.42284278
17HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.22394553
18SOX2_20726797_ChIP-Seq_SW620_Human2.21447152
19LXR_22158963_ChIP-Seq_LIVER_Mouse2.20407472
20E2F7_22180533_ChIP-Seq_HELA_Human2.19624516
21* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.17372124
22CLOCK_20551151_ChIP-Seq_293T_Human2.15593640
23ATF3_27146783_Chip-Seq_COLON_Human2.06631349
24AR_21909140_ChIP-Seq_LNCAP_Human2.05574810
25ZNF263_19887448_ChIP-Seq_K562_Human2.05241902
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.02185691
27POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.99953425
28FOXM1_23109430_ChIP-Seq_U2OS_Human1.99653313
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.97812252
30NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.97083072
31HIF1A_21447827_ChIP-Seq_MCF-7_Human1.95089372
32* RACK7_27058665_Chip-Seq_MCF-7_Human1.92886247
33ESR1_20079471_ChIP-ChIP_T-47D_Human1.90871245
34* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.87101117
35STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.86667527
36FOXO3_23340844_ChIP-Seq_DLD1_Human1.86347969
37MYC_18555785_ChIP-Seq_MESCs_Mouse1.82589430
38DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.82384155
39* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.81695427
40FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.78310141
41* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.77354097
42* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.75851158
43* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.75851158
44* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.72059247
45ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.68259390
46ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.66627456
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.66545327
48* RUNX1_27514584_Chip-Seq_MCF-7_Human1.66429945
49ESR1_15608294_ChIP-ChIP_MCF-7_Human1.65594939
50* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.59998941
51STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.59854263
52EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.59817923
53NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.55172744
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53752816
55AHR_22903824_ChIP-Seq_MCF-7_Human1.51561749
56* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.47860150
57MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.46090078
58FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.45556649
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.44949652
60NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.44764132
61FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.44153883
62NELFA_20434984_ChIP-Seq_ESCs_Mouse1.41422875
63SALL4_18804426_ChIP-ChIP_XEN_Mouse1.39288673
64STAT3_1855785_ChIP-Seq_MESCs_Mouse1.38567023
65TCF3_18692474_ChIP-Seq_MEFs_Mouse1.38360612
66* KLF5_25053715_ChIP-Seq_YYC3_Human1.38078593
67MYC_18358816_ChIP-ChIP_MESCs_Mouse1.36180889
68TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34512952
69TET1_21451524_ChIP-Seq_MESCs_Mouse1.34452064
70CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.34028712
71* KDM5A_27292631_Chip-Seq_BREAST_Human1.33691317
72TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32318840
73PKCTHETA_26484144_Chip-Seq_BREAST_Human1.32164581
74MYC_19079543_ChIP-ChIP_MESCs_Mouse1.32069834
75CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.31087955
76XRN2_22483619_ChIP-Seq_HELA_Human1.29857013
77PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.28447849
78MYC_22102868_ChIP-Seq_BL_Human1.27876147
79EGR1_23403033_ChIP-Seq_LIVER_Mouse1.27629783
80DCP1A_22483619_ChIP-Seq_HELA_Human1.27542001
81CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.25955573
82SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.25906807
83* GATA3_24758297_ChIP-Seq_MCF-7_Human1.25879031
84FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.25788366
85EGR1_19374776_ChIP-ChIP_THP-1_Human1.25631440
86ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21836231
87* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.20840789
88ERG_21242973_ChIP-ChIP_JURKAT_Human1.20301745
89OCT4_18692474_ChIP-Seq_MEFs_Mouse1.19294650
90NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19038458
91MYC_19030024_ChIP-ChIP_MESCs_Mouse1.18893006
92KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18868170
93THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18838196
94ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.17731863
95ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17672021
96TCF7_22412390_ChIP-Seq_EML_Mouse1.17492956
97* ELF5_23300383_ChIP-Seq_T47D_Human1.16040400
98ELK3_25401928_ChIP-Seq_HUVEC_Human1.14826196
99CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13490771
100JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.11670541
101ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.11596306
102VDR_21846776_ChIP-Seq_THP-1_Human1.11273894
103TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07940307
104TDRD3_21172665_ChIP-Seq_MCF-7_Human1.07869039
105LXR_22292898_ChIP-Seq_THP-1_Human1.07494230
106SMC4_20622854_ChIP-Seq_HELA_Human1.06990313
107JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06646743
108CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05991935
109UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05592653
110* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05139011
111P68_20966046_ChIP-Seq_HELA_Human1.03121466
112GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.02867988
113TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01001518
114PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00927330
115NANOG_18555785_ChIP-Seq_MESCs_Mouse0.99651928
116EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.99072991
117TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.98676456
118POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.97893882
119MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97765138
120GABP_19822575_ChIP-Seq_HepG2_Human0.96522385
121FOXA2_19822575_ChIP-Seq_HepG2_Human0.95769989
122CREB1_26743006_Chip-Seq_LNCaP_Human0.95728054
123E2F1_18555785_ChIP-Seq_MESCs_Mouse0.94768366
124* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.94483892
125* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93588188
126* CHD1_26751641_Chip-Seq_LNCaP_Human0.93302304
127* HNF4A_19822575_ChIP-Seq_HepG2_Human0.92170780
128SOX2_18692474_ChIP-Seq_MEFs_Mouse0.91823737
129FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.91197162
130* SRY_22984422_ChIP-ChIP_TESTIS_Rat0.89372375
131TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.87706791
132KLF4_18555785_ChIP-Seq_MESCs_Mouse0.86967257
133* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.86962692
134HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.85297654
135GATA2_21666600_ChIP-Seq_HMVEC_Human0.83428222
136SOX9_24532713_ChIP-Seq_HFSC_Mouse0.82260715
137CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.80593628
138* CDX2_19796622_ChIP-Seq_MESCs_Mouse0.80460972
139* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.79435965
140SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.77727258
141ELK1_22589737_ChIP-Seq_MCF10A_Human0.76833527
142* TP63_22573176_ChIP-Seq_HFKS_Human0.76358107
143AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.73233682
144TCF3_18692474_ChIP-Seq_MESCs_Mouse0.71972771

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle6.63913925
2MP0004264_abnormal_extraembryonic_tissu4.88515957
3MP0000537_abnormal_urethra_morphology3.83451111
4MP0005360_urolithiasis3.44025720
5MP0005085_abnormal_gallbladder_physiolo2.69742524
6MP0010352_gastrointestinal_tract_polyps2.64613714
7* MP0001666_abnormal_nutrient_absorption2.63000858
8MP0002139_abnormal_hepatobiliary_system2.62109362
9MP0009840_abnormal_foam_cell2.38671582
10MP0002796_impaired_skin_barrier2.26803627
11MP0009780_abnormal_chondrocyte_physiolo2.25345684
12MP0003705_abnormal_hypodermis_morpholog2.23564502
13MP0003123_paternal_imprinting2.21766309
14MP0010678_abnormal_skin_adnexa2.21683289
15MP0004233_abnormal_muscle_weight2.20984284
16MP0005365_abnormal_bile_salt2.11576641
17MP0008875_abnormal_xenobiotic_pharmacok2.07597603
18MP0003878_abnormal_ear_physiology2.06265382
19MP0005377_hearing/vestibular/ear_phenot2.06265382
20MP0005451_abnormal_body_composition2.02313106
21MP0000579_abnormal_nail_morphology1.99401330
22MP0002877_abnormal_melanocyte_morpholog1.99093677
23MP0001873_stomach_inflammation1.93613456
24MP0004019_abnormal_vitamin_homeostasis1.87413945
25MP0002254_reproductive_system_inflammat1.87274634
26MP0003566_abnormal_cell_adhesion1.86811118
27MP0003453_abnormal_keratinocyte_physiol1.83572874
28MP0003252_abnormal_bile_duct1.81538507
29MP0003300_gastrointestinal_ulcer1.80694250
30MP0006054_spinal_hemorrhage1.79517143
31MP0003806_abnormal_nucleotide_metabolis1.76233801
32MP0001849_ear_inflammation1.76070452
33MP0010155_abnormal_intestine_physiology1.73723186
34MP0003283_abnormal_digestive_organ1.69992324
35* MP0000477_abnormal_intestine_morphology1.69244508
36MP0000490_abnormal_crypts_of1.67008331
37MP0009053_abnormal_anal_canal1.66770502
38* MP0000462_abnormal_digestive_system1.63827716
39MP0008004_abnormal_stomach_pH1.61674511
40MP0002249_abnormal_larynx_morphology1.61523259
41MP0002098_abnormal_vibrissa_morphology1.60890408
42* MP0003866_abnormal_defecation1.59073803
43MP0004381_abnormal_hair_follicle1.58416260
44MP0005501_abnormal_skin_physiology1.53579357
45MP0009672_abnormal_birth_weight1.49947016
46MP0003693_abnormal_embryo_hatching1.49729490
47MP0001727_abnormal_embryo_implantation1.46242252
48MP0002234_abnormal_pharynx_morphology1.45557505
49MP0000427_abnormal_hair_cycle1.43237815
50MP0010329_abnormal_lipoprotein_level1.42776693
51MP0001664_abnormal_digestion1.39678878
52MP0009643_abnormal_urine_homeostasis1.39517115
53MP0003942_abnormal_urinary_system1.33421057
54MP0005023_abnormal_wound_healing1.33261991
55MP0005408_hypopigmentation1.32646298
56MP0003119_abnormal_digestive_system1.28792216
57MP0005058_abnormal_lysosome_morphology1.28475646
58MP0001216_abnormal_epidermal_layer1.27538511
59MP0005083_abnormal_biliary_tract1.27491142
60MP0000538_abnormal_urinary_bladder1.27357421
61* MP0005381_digestive/alimentary_phenotyp1.17889285
62MP0005409_darkened_coat_color1.15696982
63MP0008260_abnormal_autophagy1.13719053
64MP0002138_abnormal_hepatobiliary_system1.11553337
65MP0000383_abnormal_hair_follicle1.11472178
66MP0000534_abnormal_ureter_morphology1.11350350
67MP0001348_abnormal_lacrimal_gland1.11334442
68MP0002089_abnormal_postnatal_growth/wei1.11249327
69MP0003936_abnormal_reproductive_system1.11121240
70MP0002060_abnormal_skin_morphology1.09341704
71* MP0001663_abnormal_digestive_system1.08565741
72MP0005167_abnormal_blood-brain_barrier1.08324540
73MP0004272_abnormal_basement_membrane1.08282969
74MP0005367_renal/urinary_system_phenotyp1.06366752
75MP0000516_abnormal_urinary_system1.06366752
76MP0000470_abnormal_stomach_morphology1.05353093
77MP0004947_skin_inflammation1.04680177
78MP0002909_abnormal_adrenal_gland1.03791091
79MP0005084_abnormal_gallbladder_morpholo1.00363144
80MP0001346_abnormal_lacrimal_gland1.00362931
81MP0009384_cardiac_valve_regurgitation0.99344395
82MP0004957_abnormal_blastocyst_morpholog0.98660359
83MP0009931_abnormal_skin_appearance0.98230199
84MP0005332_abnormal_amino_acid0.97170623
85MP0003868_abnormal_feces_composition0.95794253
86MP0000467_abnormal_esophagus_morphology0.93517532
87MP0000377_abnormal_hair_follicle0.93050394
88MP0005076_abnormal_cell_differentiation0.92024583
89MP0000762_abnormal_tongue_morphology0.91708879
90* MP0002080_prenatal_lethality0.91649500
91MP0003191_abnormal_cellular_cholesterol0.89606538
92* MP0000609_abnormal_liver_physiology0.89553078
93MP0001756_abnormal_urination0.89522390
94MP0002088_abnormal_embryonic_growth/wei0.88835869
95MP0004858_abnormal_nervous_system0.88547470
96MP0001730_embryonic_growth_arrest0.87048319
97MP0003315_abnormal_perineum_morphology0.87046322
98MP0003638_abnormal_response/metabolism_0.86781444
99MP0003984_embryonic_growth_retardation0.86599470
100* MP0002086_abnormal_extraembryonic_tissu0.85918978
101MP0002136_abnormal_kidney_physiology0.84248033
102MP0001340_abnormal_eyelid_morphology0.84191007
103MP0003183_abnormal_peptide_metabolism0.83590152
104MP0001881_abnormal_mammary_gland0.82498179
105MP0000627_abnormal_mammary_gland0.82343070
106* MP0001697_abnormal_embryo_size0.82189374
107MP0008932_abnormal_embryonic_tissue0.82047948
108MP0010094_abnormal_chromosome_stability0.80052802
109MP0009703_decreased_birth_body0.76749558
110MP0001765_abnormal_ion_homeostasis0.76490657
111MP0002085_abnormal_embryonic_tissue0.76298078
112MP0000613_abnormal_salivary_gland0.75297166
113MP0000678_abnormal_parathyroid_gland0.74527028
114MP0000003_abnormal_adipose_tissue0.74519102
115MP0005666_abnormal_adipose_tissue0.74036144
116MP0010771_integument_phenotype0.73718571
117MP0003115_abnormal_respiratory_system0.72768411
118MP0004782_abnormal_surfactant_physiolog0.72353203
119MP0010030_abnormal_orbit_morphology0.72102373
120MP0003077_abnormal_cell_cycle0.71385801
121MP0000350_abnormal_cell_proliferation0.71221770
122MP0005257_abnormal_intraocular_pressure0.70730153
123MP0003941_abnormal_skin_development0.70212125
124MP0002118_abnormal_lipid_homeostasis0.69193821
125MP0002970_abnormal_white_adipose0.69183456
126MP0002697_abnormal_eye_size0.68716666
127MP0005636_abnormal_mineral_homeostasis0.67646332
128MP0002896_abnormal_bone_mineralization0.67620664
129MP0003111_abnormal_nucleus_morphology0.67549913
130MP0005220_abnormal_exocrine_pancreas0.67474393
131MP0000367_abnormal_coat/_hair0.67343923
132MP0000858_altered_metastatic_potential0.66618662
133MP0005187_abnormal_penis_morphology0.65852763
134MP0005319_abnormal_enzyme/_coenzyme0.65713133
135MP0009379_abnormal_foot_pigmentation0.64507195
136MP0003937_abnormal_limbs/digits/tail_de0.63650652
137MP0002111_abnormal_tail_morphology0.63610248
138MP0005248_abnormal_Harderian_gland0.63481741
139MP0003091_abnormal_cell_migration0.60699352
140MP0004185_abnormal_adipocyte_glucose0.59604143
141MP0004197_abnormal_fetal_growth/weight/0.59553522
142MP0005166_decreased_susceptibility_to0.57863175
143MP0000566_synostosis0.57327360
144MP0005380_embryogenesis_phenotype0.57021961
145MP0001672_abnormal_embryogenesis/_devel0.57021961

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)7.36702262
2J-shaped sella turcica (HP:0002680)5.59856540
3Onycholysis (HP:0001806)5.37322691
4Septate vagina (HP:0001153)5.06436188
5Ileus (HP:0002595)4.89753438
6Asymmetry of the thorax (HP:0001555)4.65997340
7Pili torti (HP:0003777)4.34377307
8Flat acetabular roof (HP:0003180)4.33930821
9Microglossia (HP:0000171)4.18035132
10Fragile nails (HP:0001808)4.10929903
11Distal lower limb muscle weakness (HP:0009053)3.91372146
12Milia (HP:0001056)3.80587577
13* Abdominal distention (HP:0003270)3.65457672
14Abnormality of monocarboxylic acid metabolism (HP:0010996)3.60935751
15* Micronodular cirrhosis (HP:0001413)3.59151100
16Focal segmental glomerulosclerosis (HP:0000097)3.57355118
17Intrahepatic cholestasis (HP:0001406)3.49318000
18Concave nail (HP:0001598)3.40892891
19Atrophic scars (HP:0001075)3.39798447
20Absent frontal sinuses (HP:0002688)3.32923507
21Abnormality of glutamine family amino acid metabolism (HP:0010902)3.22457134
22Plantar hyperkeratosis (HP:0007556)3.20741559
23Pustule (HP:0200039)3.18978083
24Malnutrition (HP:0004395)3.15268636
25Woolly hair (HP:0002224)3.14539076
26Hyperparathyroidism (HP:0000843)3.12782826
27Glomerulosclerosis (HP:0000096)3.07519076
28Biliary tract neoplasm (HP:0100574)2.99660172
29Deformed sella turcica (HP:0002681)2.98886006
30Breast carcinoma (HP:0003002)2.98290484
31Abnormality of the gastric mucosa (HP:0004295)2.97068591
32Hypobetalipoproteinemia (HP:0003563)2.88966296
33Hyperacusis (HP:0010780)2.87490185
34* Esophageal varix (HP:0002040)2.79273162
35Curly hair (HP:0002212)2.78319404
36Abnormality of the 1st metacarpal (HP:0010009)2.78027966
37Abnormal pancreas size (HP:0012094)2.76172875
38Amelogenesis imperfecta (HP:0000705)2.75402682
39Broad face (HP:0000283)2.74777177
40Abnormal biliary tract morphology (HP:0012440)2.69955091
41Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.68900763
42Xanthomatosis (HP:0000991)2.67895777
43Nail dystrophy (HP:0008404)2.65905531
44Abnormality of the frontal sinuses (HP:0002687)2.64011897
45Abnormality of the distal phalanx of the thumb (HP:0009617)2.63539035
46Abnormal hair laboratory examination (HP:0003328)2.62232352
47Hypoglycemic coma (HP:0001325)2.59068436
48Abnormality of small intestinal villus morphology (HP:0011472)2.58779017
49Villous atrophy (HP:0011473)2.58779017
50Hypoparathyroidism (HP:0000829)2.56668823
51Germ cell neoplasia (HP:0100728)2.56428617
52Abnormality of the umbilical cord (HP:0010881)2.56160480
53Thin bony cortex (HP:0002753)2.53876660
54Palpitations (HP:0001962)2.52458183
55Fat malabsorption (HP:0002630)2.49049495
56Hypokinesia (HP:0002375)2.49012422
57Vertebral hypoplasia (HP:0008417)2.47165958
58Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.47165958
59Abnormal tarsal ossification (HP:0008369)2.46578255
60Hydroxyprolinuria (HP:0003080)2.45302767
61Abnormality of proline metabolism (HP:0010907)2.45302767
62Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.45019599
63Alopecia of scalp (HP:0002293)2.44551934
64Short nail (HP:0001799)2.44182913
65Hyperactive renin-angiotensin system (HP:0000841)2.42261159
66Interstitial pulmonary disease (HP:0006530)2.41018968
67Abnormality of the distal phalanges of the toes (HP:0010182)2.38678388
68Abnormality of carpal bone ossification (HP:0006257)2.37242767
69Abnormal vertebral ossification (HP:0100569)2.37159361
70Sparse lateral eyebrow (HP:0005338)2.36873698
71Hypolipoproteinemia (HP:0010981)2.36484758
72Reticulocytosis (HP:0001923)2.36139629
73Macroorchidism (HP:0000053)2.35050807
74Late onset (HP:0003584)2.33572194
75Distal lower limb amyotrophy (HP:0008944)2.32757009
76Hypoplasia of dental enamel (HP:0006297)2.31306002
77Testicular neoplasm (HP:0010788)2.31035877
78Trismus (HP:0000211)2.30935531
79Testicular atrophy (HP:0000029)2.30706959
80Abnormality of the proximal phalanges of the hand (HP:0009834)2.26994941
81Progressive hearing impairment (HP:0001730)2.22266751
82Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.22082215
83Cupped ribs (HP:0000887)2.18040844
84Vertebral clefting (HP:0008428)2.16799564
85Uterine neoplasm (HP:0010784)2.15839079
86Deep venous thrombosis (HP:0002625)2.15531435
87Deviation of the thumb (HP:0009603)2.15202931
88Conjugated hyperbilirubinemia (HP:0002908)2.14637377
89Gastrointestinal dysmotility (HP:0002579)2.14113630
90Termporal pattern (HP:0011008)2.12520503
91Insidious onset (HP:0003587)2.12520503
92Mildly elevated creatine phosphokinase (HP:0008180)2.12240954
93Vascular calcification (HP:0004934)2.11907954
94Abnormal cartilage morphology (HP:0002763)2.11661986
95Back pain (HP:0003418)2.10573919
96Selective tooth agenesis (HP:0001592)2.09359205
97Progressive sensorineural hearing impairment (HP:0000408)2.08762603
98Abnormal foot bone ossification (HP:0010675)2.08565161
99Enlarged penis (HP:0000040)2.07161244
100Distal upper limb amyotrophy (HP:0007149)2.06227172
101Upper limb amyotrophy (HP:0009129)2.06227172
102Spinal cord compression (HP:0002176)2.05655598
103Progressive muscle weakness (HP:0003323)2.05368303
104Ureteral stenosis (HP:0000071)2.04997096
105Rectal prolapse (HP:0002035)2.04760217
106Abnormality of the sella turcica (HP:0002679)2.04535878
107Pterygium (HP:0001059)2.03684926
108Proximal placement of thumb (HP:0009623)2.03326268
109Advanced eruption of teeth (HP:0006288)2.03115038
110Chromosomal breakage induced by crosslinking agents (HP:0003221)2.02925680
111Abnormality of chloride homeostasis (HP:0011422)2.02307389
112Growth hormone excess (HP:0000845)2.01631257
113Diaphragmatic weakness (HP:0009113)2.01002206
114Hyperammonemia (HP:0001987)2.00925650
115Fragile skin (HP:0001030)2.00523461
116Gout (HP:0001997)2.00001227
117Long toe (HP:0010511)1.99060690
118Congenital ichthyosiform erythroderma (HP:0007431)1.96797938
119Microretrognathia (HP:0000308)1.96369478
120Congenital glaucoma (HP:0001087)1.96166450
121Fasciculations (HP:0002380)1.95686218
122Bicornuate uterus (HP:0000813)1.94219142
123Abnormal blistering of the skin (HP:0008066)1.93298107
124Ventricular tachycardia (HP:0004756)1.92382057
125Dehydration (HP:0001944)1.90508525
126Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.90332685
127Cervical subluxation (HP:0003308)1.89997304
128Hypoalphalipoproteinemia (HP:0003233)1.89782254
129Abnormalities of placenta or umbilical cord (HP:0001194)1.89769547
130Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.89193466
131Subacute progressive viral hepatitis (HP:0006572)1.87677062
132Abnormal ossification of hand bones (HP:0005921)1.87636074
133Malignant gastrointestinal tract tumors (HP:0006749)1.87470610
134Gastrointestinal carcinoma (HP:0002672)1.87470610
135Unilateral renal agenesis (HP:0000122)1.87225938
136Aplasia/Hypoplasia of the sacrum (HP:0008517)1.86749161
137Stridor (HP:0010307)1.86346674
138Ureteral obstruction (HP:0006000)1.85604481
139Hypercortisolism (HP:0001578)1.85450553
140Cheilitis (HP:0100825)1.84718754
141Neoplasm of the rectum (HP:0100743)1.83791494
142Cardiovascular calcification (HP:0011915)1.83378165
143Abnormal umbilical cord blood vessels (HP:0011403)1.83090251
144Single umbilical artery (HP:0001195)1.83090251
145Abnormality of the fetal cardiovascular system (HP:0010948)1.83090251
146Abnormality of aromatic amino acid family metabolism (HP:0004338)1.82309729
147Hypotrichosis (HP:0001006)1.82198662
148Lymphangioma (HP:0100764)1.80111415
149Esophageal atresia (HP:0002032)1.79958106
150Short humerus (HP:0005792)1.78971382
151Achilles tendon contracture (HP:0001771)1.78829674
152Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.78114158
153Syncope (HP:0001279)1.76677334
154Abnormality of purine metabolism (HP:0004352)1.76554608
155Chromsome breakage (HP:0040012)1.75772897
156Patellar dislocation (HP:0002999)1.75437249
157Long palpebral fissure (HP:0000637)1.75226113
158Hyperthyroidism (HP:0000836)1.74808106
159Ridged nail (HP:0001807)1.73504660
160Short phalanx of the thumb (HP:0009660)1.72935760
161Exostoses (HP:0100777)1.72812489
162Abnormality of reticulocytes (HP:0004312)1.72719043
163Bronchomalacia (HP:0002780)1.72257290
164Abnormality of sulfur amino acid metabolism (HP:0004339)1.71979281
165Sparse eyelashes (HP:0000653)1.70909451
166Goiter (HP:0000853)1.70402215
167Aplasia/hypoplasia of the humerus (HP:0006507)1.70342247
168Ankyloglossia (HP:0010296)1.69102750
169Osteolytic defects of the hand bones (HP:0009699)1.68950623
170Osteolytic defects of the phalanges of the hand (HP:0009771)1.68950623
171Increased mean platelet volume (HP:0011877)1.68892155
172Tracheal stenosis (HP:0002777)1.68166850
173Axonal loss (HP:0003447)1.67799548
174Abnormality of the Achilles tendon (HP:0005109)1.67149244
175Ragged-red muscle fibers (HP:0003200)1.66508154
176Bone pain (HP:0002653)1.66285928

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA28.93586994
2MST43.76904253
3MST1R3.46420685
4RPS6KB23.43823549
5FRK2.99114617
6SMG12.98720062
7NME22.60784336
8IRAK32.36310734
9TESK12.35243797
10PTK62.18129298
11LMTK22.13722027
12MUSK2.09409605
13PAK42.06857673
14PRKG22.04286565
15PTK21.98755592
16MAP3K21.96366738
17FER1.94684166
18MET1.94304870
19EPHB21.84834437
20RIPK11.83140741
21NME11.77845299
22VRK21.73128583
23EIF2AK11.65059236
24MAP3K31.59108857
25NEK61.55082268
26LATS11.53766283
27STK101.51270757
28TRIB31.46233313
29PRKCI1.41937856
30SIK31.41686581
31PIK3CA1.40196765
32PKN21.30679162
33ERN11.27813350
34TAOK31.25890014
35PBK1.25049513
36LRRK21.24239628
37MAP3K81.16624564
38DDR21.14875416
39LIMK11.09772267
40ERBB41.08212500
41SCYL20.98463960
42EPHB10.97821369
43STK38L0.96131497
44PLK40.92031532
45CDK120.89854555
46ERBB20.85281718
47* MAP2K20.85254422
48FGFR40.84913967
49MAP3K120.84471241
50NEK10.83300958
51MYLK0.81944920
52MAPK150.81900997
53MAP3K100.78565953
54PAK30.77627678
55MATK0.77397048
56KSR20.77377310
57GRK60.76757658
58MAP3K110.76082751
59BUB10.73952643
60LATS20.72946752
61TSSK60.71864487
62TTK0.71081485
63TESK20.68607766
64RPS6KA20.66999876
65EEF2K0.66671825
66TRIM280.65602286
67PDPK10.65070821
68MAPKAPK30.64793751
69IRAK20.64721162
70PDGFRA0.64286684
71CDK80.63708315
72SIK10.61090875
73BMX0.59988707
74STK390.59453725
75TTN0.59277980
76DYRK1B0.57963128
77DAPK10.56281540
78RPS6KA40.56029847
79TAF10.54595375
80NEK90.54558803
81TAOK10.54096867
82RET0.53378602
83CDK60.52445349
84* MAP2K10.50793341
85PIM20.49314252
86PAK10.49232596
87MAP2K60.48673937
88MAPKAPK20.48610665
89STK30.48220568
90SRPK10.48103060
91RPS6KB10.47544187
92MAP3K10.47121531
93BRSK10.42953334
94CDK90.42772906
95KDR0.40584237
96* AURKB0.38625399
97PAK20.38376332
98AKT20.38336820
99FGFR10.38192844
100MTOR0.37976741
101CHUK0.36955416
102AURKA0.36753715
103MAP3K90.36483034
104DMPK0.34638604
105* CAMK2D0.34353056
106PASK0.34260093
107BCR0.33627784
108EIF2AK20.33467017
109NUAK10.32636098
110CSF1R0.31976324
111SRC0.31151136
112GSK3A0.29934305
113MELK0.29844382
114WEE10.29389303
115* CAMK2G0.28068915
116DAPK30.27933930
117CSK0.27922549
118ILK0.27548369
119ICK0.27267927
120MAPK110.23281086
121AKT30.23094122
122CDK70.22517397
123ROCK10.21926493
124ARAF0.21905061
125STK380.21390116
126RPS6KL10.21180866
127RPS6KC10.21180866
128* CAMK2B0.20906305
129MAP3K70.20643742
130TBK10.20270993
131BCKDK0.20020632
132WNK40.20011948
133PRKD20.19812342
134CDC42BPA0.19752860
135EGFR0.19484281
136PDK10.18611311
137PRKD10.17690341
138RPS6KA10.17635402
139TAOK20.17061984

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009204.34127631
2Fat digestion and absorption_Homo sapiens_hsa049753.34662049
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.92406351
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.56012473
5Mineral absorption_Homo sapiens_hsa049782.52971700
6Proteasome_Homo sapiens_hsa030502.29053293
7Tight junction_Homo sapiens_hsa045302.13417599
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.11913601
9Histidine metabolism_Homo sapiens_hsa003402.10546246
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.09855975
11Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.02962642
12Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.02289419
13Fructose and mannose metabolism_Homo sapiens_hsa000511.81187175
14Glutathione metabolism_Homo sapiens_hsa004801.80606522
15Bile secretion_Homo sapiens_hsa049761.75795151
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.73415302
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.67419193
18Nitrogen metabolism_Homo sapiens_hsa009101.66453127
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.65443179
20Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.64848372
21Fatty acid degradation_Homo sapiens_hsa000711.64534655
22Vitamin digestion and absorption_Homo sapiens_hsa049771.63927487
23Tryptophan metabolism_Homo sapiens_hsa003801.63432508
24Bladder cancer_Homo sapiens_hsa052191.62966258
25Caffeine metabolism_Homo sapiens_hsa002321.60127663
26Galactose metabolism_Homo sapiens_hsa000521.55804597
27Adherens junction_Homo sapiens_hsa045201.55289801
28Acute myeloid leukemia_Homo sapiens_hsa052211.43851467
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.43259415
30Chemical carcinogenesis_Homo sapiens_hsa052041.40951277
31Folate biosynthesis_Homo sapiens_hsa007901.40032909
32Other glycan degradation_Homo sapiens_hsa005111.39652142
33Thyroid hormone signaling pathway_Homo sapiens_hsa049191.38948592
34AMPK signaling pathway_Homo sapiens_hsa041521.37680037
35Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.36562244
36Arginine biosynthesis_Homo sapiens_hsa002201.36540141
37Chronic myeloid leukemia_Homo sapiens_hsa052201.34781583
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.34608595
39Pentose phosphate pathway_Homo sapiens_hsa000301.32631907
40Renin-angiotensin system_Homo sapiens_hsa046141.32511399
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.28781813
42Non-small cell lung cancer_Homo sapiens_hsa052231.27645693
43Thyroid cancer_Homo sapiens_hsa052161.26786326
44PPAR signaling pathway_Homo sapiens_hsa033201.21366191
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.21253054
46Hippo signaling pathway_Homo sapiens_hsa043901.20255781
47Insulin signaling pathway_Homo sapiens_hsa049101.18586415
48Selenocompound metabolism_Homo sapiens_hsa004501.15318678
49Renal cell carcinoma_Homo sapiens_hsa052111.14352261
50Starch and sucrose metabolism_Homo sapiens_hsa005001.12231608
51Vitamin B6 metabolism_Homo sapiens_hsa007501.11415446
52Longevity regulating pathway - mammal_Homo sapiens_hsa042111.11152339
53Carbon metabolism_Homo sapiens_hsa012001.09562424
54ErbB signaling pathway_Homo sapiens_hsa040121.08668344
55DNA replication_Homo sapiens_hsa030301.07377591
56mTOR signaling pathway_Homo sapiens_hsa041501.07303980
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.05506170
58Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.05410632
59Small cell lung cancer_Homo sapiens_hsa052221.05063242
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04528357
61Sulfur relay system_Homo sapiens_hsa041221.04390712
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03918492
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.02518535
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02384744
65Retinol metabolism_Homo sapiens_hsa008300.99962269
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.99678559
67Insulin resistance_Homo sapiens_hsa049310.98298270
68Glycerolipid metabolism_Homo sapiens_hsa005610.97811346
69Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.97798154
70VEGF signaling pathway_Homo sapiens_hsa043700.97319499
71Arginine and proline metabolism_Homo sapiens_hsa003300.95407897
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.95287483
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.94810791
74Base excision repair_Homo sapiens_hsa034100.93743479
75Linoleic acid metabolism_Homo sapiens_hsa005910.93699838
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.90561178
77Pyruvate metabolism_Homo sapiens_hsa006200.88750323
78Fatty acid elongation_Homo sapiens_hsa000620.88655501
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.85613348
80Pancreatic cancer_Homo sapiens_hsa052120.85371708
81Biosynthesis of amino acids_Homo sapiens_hsa012300.84913458
82Phenylalanine metabolism_Homo sapiens_hsa003600.83251575
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.81702239
84ECM-receptor interaction_Homo sapiens_hsa045120.81574648
85Sphingolipid metabolism_Homo sapiens_hsa006000.81404036
86Protein digestion and absorption_Homo sapiens_hsa049740.81203189
87Glioma_Homo sapiens_hsa052140.81085954
88Prostate cancer_Homo sapiens_hsa052150.80275584
89beta-Alanine metabolism_Homo sapiens_hsa004100.79650057
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.79089981
91RNA transport_Homo sapiens_hsa030130.77908844
92Estrogen signaling pathway_Homo sapiens_hsa049150.75971166
93Hepatitis C_Homo sapiens_hsa051600.75061394
94Inositol phosphate metabolism_Homo sapiens_hsa005620.74367439
95Proteoglycans in cancer_Homo sapiens_hsa052050.74282220
96Thyroid hormone synthesis_Homo sapiens_hsa049180.74271708
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73790478
98Notch signaling pathway_Homo sapiens_hsa043300.73779892
99Butanoate metabolism_Homo sapiens_hsa006500.72791810
100Spliceosome_Homo sapiens_hsa030400.69282938
101Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68904451
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.67971942
103Pancreatic secretion_Homo sapiens_hsa049720.65863972
104Basal cell carcinoma_Homo sapiens_hsa052170.65406974
105Choline metabolism in cancer_Homo sapiens_hsa052310.64457409
106Melanoma_Homo sapiens_hsa052180.64335855
107Hedgehog signaling pathway_Homo sapiens_hsa043400.63184587
108Lysosome_Homo sapiens_hsa041420.59907538
109Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59500442
110Cysteine and methionine metabolism_Homo sapiens_hsa002700.59285101
111Fatty acid metabolism_Homo sapiens_hsa012120.57905670
112Prolactin signaling pathway_Homo sapiens_hsa049170.57159358
113Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55927301
114Focal adhesion_Homo sapiens_hsa045100.53984087
115N-Glycan biosynthesis_Homo sapiens_hsa005100.53424988
116Steroid hormone biosynthesis_Homo sapiens_hsa001400.52931887
117Arachidonic acid metabolism_Homo sapiens_hsa005900.52265856
118Vibrio cholerae infection_Homo sapiens_hsa051100.51540174
119Amoebiasis_Homo sapiens_hsa051460.51350191
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.50965561
121Glucagon signaling pathway_Homo sapiens_hsa049220.50401300
122Salmonella infection_Homo sapiens_hsa051320.50245889
123Endocytosis_Homo sapiens_hsa041440.50135041
124Pyrimidine metabolism_Homo sapiens_hsa002400.49402968
125Peroxisome_Homo sapiens_hsa041460.49068325
126Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47033399
127Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46117421
128TGF-beta signaling pathway_Homo sapiens_hsa043500.45577033
129p53 signaling pathway_Homo sapiens_hsa041150.44871574
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44525709
131Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43066074
132Complement and coagulation cascades_Homo sapiens_hsa046100.42215363
133Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41575261
134Shigellosis_Homo sapiens_hsa051310.41537649
135Endometrial cancer_Homo sapiens_hsa052130.41323042
136Cell cycle_Homo sapiens_hsa041100.40936032
137Axon guidance_Homo sapiens_hsa043600.40727895
138HIF-1 signaling pathway_Homo sapiens_hsa040660.39992074
139ABC transporters_Homo sapiens_hsa020100.39927966
140Lysine degradation_Homo sapiens_hsa003100.39924719
141mRNA surveillance pathway_Homo sapiens_hsa030150.39355144
142MicroRNAs in cancer_Homo sapiens_hsa052060.38480838
143Tyrosine metabolism_Homo sapiens_hsa003500.36276326
144Toxoplasmosis_Homo sapiens_hsa051450.34684236
145Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.34415336
146Legionellosis_Homo sapiens_hsa051340.32780990
147Metabolic pathways_Homo sapiens_hsa011000.32037188
148Central carbon metabolism in cancer_Homo sapiens_hsa052300.29996949
149Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27819999
150Steroid biosynthesis_Homo sapiens_hsa001000.23978435

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