KRT40

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1adhesion of symbiont to host cell (GO:0044650)9.63496453
2virion attachment to host cell (GO:0019062)9.63496453
3peptide cross-linking (GO:0018149)8.17615580
4citrulline biosynthetic process (GO:0019240)8.11261662
5adhesion of symbiont to host (GO:0044406)8.05949218
6type B pancreatic cell development (GO:0003323)8.05657906
7hair follicle morphogenesis (GO:0031069)7.75702659
8epithelial cell fate commitment (GO:0072148)7.48612636
9cell wall macromolecule catabolic process (GO:0016998)7.05307809
10cell wall macromolecule metabolic process (GO:0044036)7.05307809
11establishment of skin barrier (GO:0061436)6.73083859
12intermediate filament cytoskeleton organization (GO:0045104)6.46331422
13skeletal muscle tissue regeneration (GO:0043403)6.39290080
14peripheral nervous system neuron development (GO:0048935)6.35652963
15intermediate filament-based process (GO:0045103)6.28316164
16astrocyte differentiation (GO:0048708)6.27672739
17epidermis development (GO:0008544)6.20171832
18middle ear morphogenesis (GO:0042474)6.18086465
19peristalsis (GO:0030432)5.98773496
20dendritic spine morphogenesis (GO:0060997)5.98413349
21keratinocyte differentiation (GO:0030216)5.95453066
22regulation of water loss via skin (GO:0033561)5.93542559
23glandular epithelial cell development (GO:0002068)5.85909055
24iron ion import (GO:0097286)5.82441415
25oligosaccharide catabolic process (GO:0009313)5.64878140
26proximal/distal pattern formation (GO:0009954)5.62380696
27neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)5.51665850
28response to phenylpropanoid (GO:0080184)5.46222816
29molting cycle process (GO:0022404)5.44771612
30hair cycle process (GO:0022405)5.44771612
31signal transduction involved in regulation of gene expression (GO:0023019)5.34377497
32neuron fate specification (GO:0048665)5.31178100
33citrulline metabolic process (GO:0000052)5.30541874
34neuron fate determination (GO:0048664)5.13422840
35urinary tract smooth muscle contraction (GO:0014848)5.07159559
36prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060525.06166795
37bundle of His cell to Purkinje myocyte communication (GO:0086069)5.00777524
38skin morphogenesis (GO:0043589)4.97216022
39adaptation of signaling pathway (GO:0023058)4.83910382
40spinal cord association neuron differentiation (GO:0021527)4.82880286
41negative regulation of heart contraction (GO:0045822)4.75520593
42tooth mineralization (GO:0034505)4.65408608
43epidermal cell differentiation (GO:0009913)4.61068640
44peptidyl-arginine modification (GO:0018195)4.59007691
45hemidesmosome assembly (GO:0031581)4.52438812
46righting reflex (GO:0060013)4.44788879
47male sex determination (GO:0030238)4.26067329
48import into cell (GO:0098657)4.14542703
49negative regulation of systemic arterial blood pressure (GO:0003085)4.14102196
50calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)4.12434632
51keratinocyte development (GO:0003334)4.07901185
52molting cycle (GO:0042303)32.1596452
53hair cycle (GO:0042633)32.1596452
54multicellular organismal water homeostasis (GO:0050891)3.96751678
55cell fate specification (GO:0001708)3.95939059
56multicellular organismal movement (GO:0050879)3.94773657
57musculoskeletal movement (GO:0050881)3.94773657
58Leydig cell differentiation (GO:0033327)3.94294481
59dorsal/ventral pattern formation (GO:0009953)3.92222105
60hypothalamus development (GO:0021854)3.90055947
61regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.89691971
62negative regulation of blood circulation (GO:1903523)3.85301231
63negative regulation of hormone biosynthetic process (GO:0032353)3.84165662
64chemosensory behavior (GO:0007635)3.78632218
65negative regulation of multicellular organism growth (GO:0040015)3.77286622
66columnar/cuboidal epithelial cell development (GO:0002066)3.76655398
67hair follicle development (GO:0001942)3.75824310
68regulation of keratinocyte differentiation (GO:0045616)3.69100349
69positive regulation of meiotic cell cycle (GO:0051446)3.66818116
70positive regulation of oligodendrocyte differentiation (GO:0048714)3.66664296
71phasic smooth muscle contraction (GO:0014821)3.66269729
72vasodilation (GO:0042311)3.59217740
73dendritic spine organization (GO:0097061)3.54144858
74cell differentiation in spinal cord (GO:0021515)3.51376564
75endothelial cell chemotaxis (GO:0035767)3.49278554
76negative regulation of gluconeogenesis (GO:0045721)3.42382377
77cellular response to gonadotropin stimulus (GO:0071371)3.36207856
78negative regulation of hormone metabolic process (GO:0032351)3.35574198
79glycosphingolipid catabolic process (GO:0046479)3.32681399
80endocrine pancreas development (GO:0031018)3.30826283
81negative regulation of bone resorption (GO:0045779)3.29682799
82negative regulation of keratinocyte proliferation (GO:0010839)3.28639856
83negative regulation of establishment of protein localization to plasma membrane (GO:0090005)3.28216850
84regulation of skeletal muscle cell differentiation (GO:2001014)3.27723778
85vasoconstriction (GO:0042310)3.26905401
86water homeostasis (GO:0030104)3.23627850
87sensory perception of mechanical stimulus (GO:0050954)3.18510941
88bone trabecula formation (GO:0060346)3.18333698
89positive regulation of hair follicle development (GO:0051798)3.16518217
90positive regulation of hair cycle (GO:0042635)3.16518217
91regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.15576390
92regulation of microtubule-based movement (GO:0060632)3.13448928
93phosphatidylinositol acyl-chain remodeling (GO:0036149)3.12643022
94regulation of mesenchymal cell apoptotic process (GO:2001053)3.12583628
95indolalkylamine metabolic process (GO:0006586)3.10537338
96regulation of glucose import in response to insulin stimulus (GO:2001273)3.09928752
97G-protein coupled receptor internalization (GO:0002031)3.06191429
98glycoprotein catabolic process (GO:0006516)3.06188501
99vocalization behavior (GO:0071625)3.05033684
100carnitine shuttle (GO:0006853)3.04878006
101spinal cord motor neuron differentiation (GO:0021522)3.03594228
102sex determination (GO:0007530)3.03315678
103embryonic skeletal system morphogenesis (GO:0048704)3.02129980
104protein localization to synapse (GO:0035418)3.01622158
105regulation of hair follicle development (GO:0051797)3.01108523
106epithelium development (GO:0060429)3.00777954
107vitamin catabolic process (GO:0009111)3.00705344
108fat-soluble vitamin catabolic process (GO:0042363)3.00705344
109serotonin metabolic process (GO:0042428)2.99758354
110glycolipid catabolic process (GO:0019377)2.98754979
111lymph vessel development (GO:0001945)2.97323636
112kynurenine metabolic process (GO:0070189)2.96140534
113sphingoid metabolic process (GO:0046519)2.94904545
114sensory perception of sound (GO:0007605)2.92315758
115photoreceptor cell maintenance (GO:0045494)2.91711949
116regulation of smooth muscle cell differentiation (GO:0051150)2.90029455
117phosphatidylserine acyl-chain remodeling (GO:0036150)2.88549167
118kidney morphogenesis (GO:0060993)2.88237632
119ganglioside metabolic process (GO:0001573)2.87177399
120detection of mechanical stimulus (GO:0050982)2.84325083
121fatty acid elongation (GO:0030497)2.84052609
122indole-containing compound catabolic process (GO:0042436)2.83311713
123indolalkylamine catabolic process (GO:0046218)2.83311713
124tryptophan catabolic process (GO:0006569)2.83311713
125cranial nerve development (GO:0021545)2.81133764
126regulation of type B pancreatic cell apoptotic process (GO:2000674)2.80465954
127epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.80214665
128regulation of glucokinase activity (GO:0033131)2.78704122
129regulation of hexokinase activity (GO:1903299)2.78704122
130negative regulation of smooth muscle contraction (GO:0045986)2.78630195
131regulation of hair cycle (GO:0042634)2.78348500
132regulation of blood vessel size (GO:0050880)2.78299859
133smooth muscle cell differentiation (GO:0051145)2.78195942
134regulation of tube size (GO:0035150)2.77063777
135lactate metabolic process (GO:0006089)2.74778658
136histone H3-K9 demethylation (GO:0033169)2.74514768
137regulation of epidermal cell differentiation (GO:0045604)2.73393391
138negative regulation of protein localization to plasma membrane (GO:1903077)2.69830590
139ectoderm development (GO:0007398)2.67066173
140outflow tract septum morphogenesis (GO:0003148)2.63325856
141regulation of cardioblast proliferation (GO:0003264)2.56066991
142regulation of secondary heart field cardioblast proliferation (GO:0003266)2.56066991
143regulation of epidermis development (GO:0045682)2.54284493
144gap junction assembly (GO:0016264)2.53588765
145positive regulation of monocyte chemotaxis (GO:0090026)2.52958203
146phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.50331429
147atrioventricular valve morphogenesis (GO:0003181)2.47007019
148positive regulation of epidermis development (GO:0045684)2.44673789
149myotube differentiation (GO:0014902)2.43081422
150coronary vasculature morphogenesis (GO:0060977)2.41885594
151cranial suture morphogenesis (GO:0060363)2.40932348
152outer ear morphogenesis (GO:0042473)2.39968025
153positive regulation of meiosis (GO:0045836)2.39126669
154ventricular cardiac muscle cell action potential (GO:0086005)2.35454126
155cell surface receptor signaling pathway involved in heart development (GO:0061311)2.32233782
156phosphatidylserine metabolic process (GO:0006658)2.30796640
157ephrin receptor signaling pathway (GO:0048013)2.27382086
158skin development (GO:0043588)2.25074006
159negative regulation of cell fate specification (GO:0009996)2.21756237
160wound healing, spreading of epidermal cells (GO:0035313)2.15360454
161cell communication involved in cardiac conduction (GO:0086065)2.10519144
162negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.10161636
163phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.08112985
164negative regulation of epidermis development (GO:0045683)2.02591266
165dorsal/ventral neural tube patterning (GO:0021904)15.1023299
166keratinization (GO:0031424)11.6570907
167intermediate filament organization (GO:0045109)11.5312730
168adrenergic receptor signaling pathway (GO:0071875)10.3217158
169desmosome organization (GO:0002934)10.0424376
170regulation of keratinocyte proliferation (GO:0010837)1.98345435
171cytoskeletal anchoring at plasma membrane (GO:0007016)1.96768851
172regulation of heart rate by cardiac conduction (GO:0086091)1.93705444
173muscle organ morphogenesis (GO:0048644)1.93087033
174regulation of ruffle assembly (GO:1900027)1.92254235
175epithelial cell-cell adhesion (GO:0090136)1.90929645
176keratinocyte proliferation (GO:0043616)1.88773480
177non-canonical Wnt signaling pathway (GO:0035567)1.87243925
178positive regulation of epidermal cell differentiation (GO:0045606)1.85856221
179planar cell polarity pathway involved in neural tube closure (GO:0090179)1.84976855
180regulation of cardioblast differentiation (GO:0051890)1.84709556
181lens development in camera-type eye (GO:0002088)1.82330637
182adenine nucleotide transport (GO:0051503)1.81462628
183phosphatidylcholine acyl-chain remodeling (GO:0036151)1.78877498
184purine ribonucleotide transport (GO:0015868)1.77002738
185alditol phosphate metabolic process (GO:0052646)1.76701949
186aging (GO:0007568)1.76437210
187regulation of monocyte chemotaxis (GO:0090025)1.75724775
188regulation of Wnt signaling pathway involved in heart development (GO:0003307)1.73384225
189craniofacial suture morphogenesis (GO:0097094)1.71889561
190embryonic viscerocranium morphogenesis (GO:0048703)1.70311212
191regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)1.69676164
192odontogenesis of dentin-containing tooth (GO:0042475)1.67799795
193cardiac epithelial to mesenchymal transition (GO:0060317)1.67542892

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.72405104
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.04348669
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.41865895
4CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.53102226
5P63_26484246_Chip-Seq_KERATINOCYTES_Human3.31090199
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.26620560
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.26620560
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.26620560
9PHC1_16625203_ChIP-ChIP_MESCs_Mouse3.08323165
10TP63_19390658_ChIP-ChIP_HaCaT_Human3.06585578
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.67907500
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.53665420
13DROSHA_22980978_ChIP-Seq_HELA_Human2.44328872
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.42418724
15RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.24427125
16EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.15699234
17TP63_17297297_ChIP-ChIP_HaCaT_Human11.1927652
18CTCF_20526341_ChIP-Seq_ESCs_Human1.92187085
19NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.91755548
20POU5F1_16153702_ChIP-ChIP_HESCs_Human1.84327963
21BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.73986778
22SOX9_24532713_ChIP-Seq_HFSC_Mouse1.67815991
23TP53_20018659_ChIP-ChIP_R1E_Mouse1.61199277
24PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.60895707
25VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.60573226
26EGR1_19032775_ChIP-ChIP_M12_Human1.59155599
27ARNT_22903824_ChIP-Seq_MCF-7_Human1.58398402
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.57938266
29AHR_22903824_ChIP-Seq_MCF-7_Human1.57900111
30TAF2_19829295_ChIP-Seq_ESCs_Human1.56887399
31ERG_20517297_ChIP-Seq_VCAP_Human1.56262316
32RNF2_27304074_Chip-Seq_NSC_Mouse1.55674290
33* P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.54862087
34JARID2_20075857_ChIP-Seq_MESCs_Mouse1.51615261
35FOXO3_23340844_ChIP-Seq_DLD1_Human1.50997314
36CSB_26484114_Chip-Seq_FIBROBLAST_Human1.50135862
37WT1_19549856_ChIP-ChIP_CCG9911_Human1.50098761
38MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.48196508
39CTCF_27219007_Chip-Seq_Bcells_Human1.47793874
40NANOG_20526341_ChIP-Seq_ESCs_Human1.45609469
41E2F1_20622854_ChIP-Seq_HELA_Human1.44714602
42P53_21459846_ChIP-Seq_SAOS-2_Human1.39505728
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.38768994
44SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.36886714
45SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.36886714
46TP53_18474530_ChIP-ChIP_U2OS_Human1.35967188
47SMAD3_21741376_ChIP-Seq_HESCs_Human1.35477162
48ESR1_20079471_ChIP-ChIP_T-47D_Human1.33107654
49ESR1_21235772_ChIP-Seq_MCF-7_Human1.33053707
50TP63_22573176_ChIP-Seq_HFKS_Human1.29342559
51ESR2_21235772_ChIP-Seq_MCF-7_Human1.28979859
52RNF2_27304074_Chip-Seq_ESCs_Mouse1.27750573
53RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26953282
54IKZF1_21737484_ChIP-ChIP_HCT116_Human1.26634225
55RING1B_27294783_Chip-Seq_NPCs_Mouse1.26573774
56DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24383030
57AR_21572438_ChIP-Seq_LNCaP_Human1.23500559
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23133847
59CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22325532
60GF1_26923725_Chip-Seq_HPCs_Mouse1.22128547
61EZH2_27304074_Chip-Seq_ESCs_Mouse1.21828421
62SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.20744944
63RACK7_27058665_Chip-Seq_MCF-7_Human1.20184566
64TP63_23658742_ChIP-Seq_EP156T_Human1.19020193
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.18954639
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.18529629
67LXR_22292898_ChIP-Seq_THP-1_Human1.17424128
68YY1_22570637_ChIP-Seq_MALME-3M_Human1.17327139
69ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17265986
70SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.17170105
71EZH2_27294783_Chip-Seq_ESCs_Mouse1.17036614
72JARID2_20064375_ChIP-Seq_MESCs_Mouse1.15092900
73GATA3_24758297_ChIP-Seq_MCF-7_Human1.14196035
74SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.14006427
75CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13481974
76BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13182159
77SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.12722815
78RNF2_18974828_ChIP-Seq_MESCs_Mouse1.12566487
79EZH2_18974828_ChIP-Seq_MESCs_Mouse1.12566487
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12143377
81UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11785436
82KLF5_25053715_ChIP-Seq_YYC3_Human1.10795069
83CEBPB_22108803_ChIP-Seq_LS180_Human1.09038971
84SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.09035216
85BCL6_27268052_Chip-Seq_Bcells_Human1.08926175
86RING1B_27294783_Chip-Seq_ESCs_Mouse1.08073230
87REST_21632747_ChIP-Seq_MESCs_Mouse1.07774163
88JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06707373
89ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.06257658
90ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06108097
91EED_16625203_ChIP-ChIP_MESCs_Mouse1.05576819
92RXR_22108803_ChIP-Seq_LS180_Human1.04676225
93RARG_19884340_ChIP-ChIP_MEFs_Mouse1.03863960
94SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.01711900
95JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01466249
96TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01010488
97GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.00646082
98ERG_21242973_ChIP-ChIP_JURKAT_Human0.99699756
99TRIM28_21343339_ChIP-Seq_HEK293_Human0.99497159
100ELK4_26923725_Chip-Seq_MESODERM_Mouse0.99100925
101BCOR_27268052_Chip-Seq_Bcells_Human0.97766773
102NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.97461540
103SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97393749
104KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96633601
105GATA4_25053715_ChIP-Seq_YYC3_Human0.95880386
106ATF3_27146783_Chip-Seq_COLON_Human0.95273833
107SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.95028377
108KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94723493
109CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.93570266
110KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.93191217
111GATA6_21074721_ChIP-Seq_CACO-2_Human0.92646036
112SMAD4_21741376_ChIP-Seq_HESCs_Human0.92505499
113TP53_16413492_ChIP-PET_HCT116_Human0.92349249
114FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.92344891
115TCF4_18268006_ChIP-ChIP_LS174T_Human0.89265277
116SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.88987789
117PHF8_20622854_ChIP-Seq_HELA_Human0.88950722
118E2F1_17053090_ChIP-ChIP_MCF-7_Human0.88819027
119EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88608271
120P68_20966046_ChIP-Seq_HELA_Human0.87492818
121MTF2_20144788_ChIP-Seq_MESCs_Mouse0.87204804
122REST_18959480_ChIP-ChIP_MESCs_Mouse0.87182891
123RAC3_21632823_ChIP-Seq_H3396_Human0.85534403
124SMC4_20622854_ChIP-Seq_HELA_Human0.85195018
125BCAT_22108803_ChIP-Seq_LS180_Human0.85034091
126RAD21_21589869_ChIP-Seq_MESCs_Mouse0.84269942
127GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84083443
128DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.84016409
129SA1_27219007_Chip-Seq_ERYTHROID_Human0.83109602
130P300_27058665_Chip-Seq_ZR-75-30cells_Human0.82481524
131NANOG_18555785_Chip-Seq_ESCs_Mouse0.82099064
132LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81932909
133SMAD4_21799915_ChIP-Seq_A2780_Human0.81530430
134UBF1/2_26484160_Chip-Seq_HMECs_Human0.81299078
135CBX2_27304074_Chip-Seq_ESCs_Mouse0.81292133
136NFE2_27457419_Chip-Seq_LIVER_Mouse0.80463089
137SOX2_20726797_ChIP-Seq_SW620_Human0.78925351
138SOX2_21211035_ChIP-Seq_LN229_Human0.78849069
139SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.78496555
140* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.78173523
141FOXH1_21741376_ChIP-Seq_ESCs_Human0.78134298
142TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.77893229
143RUNX1_27514584_Chip-Seq_MCF-7_Human0.77267037
144LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76439393
145FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.75310537
146ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.74868814
147CTBP1_25329375_ChIP-Seq_LNCAP_Human0.74834948
148PCGF2_27294783_Chip-Seq_ESCs_Mouse0.74392109
149TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.74249676
150ZFP281_27345836_Chip-Seq_ESCs_Mouse0.70342273
151SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.68683063
152STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.68348005
153SUZ12_27294783_Chip-Seq_NPCs_Mouse0.67936797
154PCGF2_27294783_Chip-Seq_NPCs_Mouse0.67440959
155PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.67342188
156AR_19668381_ChIP-Seq_PC3_Human0.67175632
157TCF4_22108803_ChIP-Seq_LS180_Human0.66276681
158SOX2_21211035_ChIP-Seq_LN229_Gbm0.65529916
159TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.65314809
160EP300_21415370_ChIP-Seq_HL-1_Mouse0.64878481
161EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.64876563
162AR_25329375_ChIP-Seq_VCAP_Human0.63612432
163WT1_25993318_ChIP-Seq_PODOCYTE_Human0.62985553
164FLI1_21867929_ChIP-Seq_TH2_Mouse0.61854626
165TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.61416513
166TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.61333310
167HOXB7_26014856_ChIP-Seq_BT474_Human0.61060076
168SOX3_22085726_ChIP-Seq_NPCs_Mouse0.60132886
169POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.59493989

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology7.63860487
2MP0002098_abnormal_vibrissa_morphology6.69890763
3MP0000647_abnormal_sebaceous_gland6.24136153
4MP0003878_abnormal_ear_physiology6.10000183
5MP0005377_hearing/vestibular/ear_phenot6.10000183
6MP0002796_impaired_skin_barrier5.98904863
7MP0002163_abnormal_gland_morphology5.94328574
8MP0005275_abnormal_skin_tensile5.31062662
9MP0002277_abnormal_respiratory_mucosa5.12025023
10MP0000383_abnormal_hair_follicle5.03469986
11MP0002102_abnormal_ear_morphology4.90531828
12MP0005394_taste/olfaction_phenotype4.57326328
13MP0005499_abnormal_olfactory_system4.57326328
14MP0010234_abnormal_vibrissa_follicle4.54303371
15MP0010678_abnormal_skin_adnexa4.32693936
16MP0000377_abnormal_hair_follicle4.03730241
17MP0000427_abnormal_hair_cycle3.80838798
18MP0005501_abnormal_skin_physiology3.71277869
19MP0005379_endocrine/exocrine_gland_phen3.70442071
20MP0003705_abnormal_hypodermis_morpholog3.30609621
21MP0002653_abnormal_ependyma_morphology3.10074451
22MP0001486_abnormal_startle_reflex2.97804757
23MP0002254_reproductive_system_inflammat2.92564105
24MP0003879_abnormal_hair_cell2.91234696
25MP0004142_abnormal_muscle_tone2.87629003
26MP0001216_abnormal_epidermal_layer2.70554467
27MP0005503_abnormal_tendon_morphology2.54420586
28MP0010771_integument_phenotype2.39075170
29MP0004381_abnormal_hair_follicle2.32520802
30MP0002234_abnormal_pharynx_morphology2.31046662
31MP0004947_skin_inflammation2.30517270
32MP0000367_abnormal_coat/_hair2.25789626
33MP0002060_abnormal_skin_morphology2.07501330
34MP0009780_abnormal_chondrocyte_physiolo2.04506943
35MP0003453_abnormal_keratinocyte_physiol2.04025684
36MP0001243_abnormal_dermal_layer2.02188606
37MP0003195_calcinosis1.96280018
38MP0002233_abnormal_nose_morphology1.93741337
39MP0004510_myositis1.93280944
40MP0003656_abnormal_erythrocyte_physiolo1.91257714
41MP0001485_abnormal_pinna_reflex1.82798793
42MP0002932_abnormal_joint_morphology1.81543482
43MP0002108_abnormal_muscle_morphology1.79507007
44MP0005187_abnormal_penis_morphology1.77902997
45MP0000428_abnormal_craniofacial_morphol1.69929801
46MP0002822_catalepsy1.66249507
47MP0005409_darkened_coat_color1.65968255
48MP0003172_abnormal_lysosome_physiology1.61963186
49MP0000467_abnormal_esophagus_morphology1.52477365
50MP0000762_abnormal_tongue_morphology1.48326328
51MP0000750_abnormal_muscle_regeneration1.48311830
52MP0009931_abnormal_skin_appearance1.47462784
53MP0003941_abnormal_skin_development1.46037517
54MP0009053_abnormal_anal_canal1.25686928
55MP0003566_abnormal_cell_adhesion1.24947957
56MP0000759_abnormal_skeletal_muscle1.21791183
57MP0000566_synostosis1.18772139
58MP0002909_abnormal_adrenal_gland1.13307963
59MP0002095_abnormal_skin_pigmentation1.09927636
60MP0004885_abnormal_endolymph1.08493539
61MP0006276_abnormal_autonomic_nervous1.07735546
62MP0001191_abnormal_skin_condition1.06535514
63MP0003866_abnormal_defecation1.05334480
64MP0001963_abnormal_hearing_physiology0.99698884
65MP0005220_abnormal_exocrine_pancreas0.98733310
66MP0005076_abnormal_cell_differentiation0.98208859
67MP0000026_abnormal_inner_ear0.97953514
68MP0001944_abnormal_pancreas_morphology0.96930760
69MP0010307_abnormal_tumor_latency0.94589961
70MP0002877_abnormal_melanocyte_morpholog0.91677746
71MP0001346_abnormal_lacrimal_gland0.89689340
72MP0008872_abnormal_physiological_respon0.89584770
73MP0002896_abnormal_bone_mineralization0.88003150
74MP0009745_abnormal_behavioral_response0.87390047
75MP0002697_abnormal_eye_size0.85701791
76MP0002184_abnormal_innervation0.80564083
77MP0000163_abnormal_cartilage_morphology0.80353654
78MP0001661_extended_life_span0.76807002
79MP0001542_abnormal_bone_strength0.76610120
80MP0000534_abnormal_ureter_morphology0.75907714
81MP0003283_abnormal_digestive_organ0.75836032
82MP0001188_hyperpigmentation0.75764750
83MP0000678_abnormal_parathyroid_gland0.75190486
84MP0001340_abnormal_eyelid_morphology0.72006909
85MP0005334_abnormal_fat_pad0.71922237
86MP0000767_abnormal_smooth_muscle0.71041630
87MP0002229_neurodegeneration0.71022038
88MP0003122_maternal_imprinting0.71001343
89MP0001440_abnormal_grooming_behavior0.70756000
90MP0000955_abnormal_spinal_cord0.70513492
91MP0004185_abnormal_adipocyte_glucose0.69861570
92MP0004264_abnormal_extraembryonic_tissu0.69057599
93MP0005369_muscle_phenotype0.68180627
94MP0002116_abnormal_craniofacial_bone0.66224833
95MP0009379_abnormal_foot_pigmentation0.64346304
96MP0008438_abnormal_cutaneous_collagen0.63136074
97MP0005551_abnormal_eye_electrophysiolog0.62475158
98MP0001851_eye_inflammation0.61532193
99MP0000747_muscle_weakness0.61026543
100MP0002557_abnormal_social/conspecific_i0.60905947
101MP0010030_abnormal_orbit_morphology0.60662882
102MP0002249_abnormal_larynx_morphology0.60047677
103MP0002063_abnormal_learning/memory/cond0.59547351
104MP0006072_abnormal_retinal_apoptosis0.59423893
105MP0002272_abnormal_nervous_system0.57975960
106MP0003315_abnormal_perineum_morphology0.56762700
107MP0002115_abnormal_skeleton_extremities0.56633572
108MP0002938_white_spotting0.55185913
109MP0000230_abnormal_systemic_arterial0.55185037
110MP0002089_abnormal_postnatal_growth/wei0.54443216
111MP0003279_aneurysm0.53268087
112MP0005448_abnormal_energy_balance0.52865098
113MP0002734_abnormal_mechanical_nocicepti0.51916061
114MP0005248_abnormal_Harderian_gland0.50806971
115MP0001849_ear_inflammation0.50121281
116MP0002177_abnormal_outer_ear0.49817337
117MP0003329_amyloid_beta_deposits0.49338069
118MP0003635_abnormal_synaptic_transmissio0.49215968
119MP0000627_abnormal_mammary_gland0.48686038
120MP0002282_abnormal_trachea_morphology0.47614033
121MP0002332_abnormal_exercise_endurance0.47163691
122MP0003755_abnormal_palate_morphology0.47147920
123MP0005193_abnormal_anterior_eye0.46401468
124MP0001784_abnormal_fluid_regulation0.45927152
125MP0002693_abnormal_pancreas_physiology0.45078771
126MP0002752_abnormal_somatic_nervous0.44513683
127MP0002069_abnormal_eating/drinking_beha0.43705877
128MP0002882_abnormal_neuron_morphology0.41839698
129MP0001943_abnormal_respiration0.41138575
130MP0002572_abnormal_emotion/affect_behav0.40372118
131MP0002114_abnormal_axial_skeleton0.39731853
132MP0005666_abnormal_adipose_tissue0.39249816
133MP0000639_abnormal_adrenal_gland0.39019902
134MP0005266_abnormal_metabolism0.36905870
135MP0002638_abnormal_pupillary_reflex0.36514457
136MP0000013_abnormal_adipose_tissue0.36107818
137MP0001727_abnormal_embryo_implantation0.35587063
138MP0003191_abnormal_cellular_cholesterol0.35224522
139MP0002106_abnormal_muscle_physiology0.35115974
140MP0005375_adipose_tissue_phenotype0.34928742
141MP0002111_abnormal_tail_morphology0.33703418
142MP0002970_abnormal_white_adipose0.32530401
143MP0004270_analgesia0.32041031
144MP0001879_abnormal_lymphatic_vessel0.32029840
145MP0003385_abnormal_body_wall0.31569239
146MP0002009_preneoplasia0.29405876
147MP0000537_abnormal_urethra_morphology0.28993612
148MP0004742_abnormal_vestibular_system0.28895274
149MP0005451_abnormal_body_composition0.28800953
150MP0004272_abnormal_basement_membrane0.27385925
151MP0002837_dystrophic_cardiac_calcinosis0.26831129
152MP0005023_abnormal_wound_healing0.26107601
153MP0004484_altered_response_of0.25451863
154MP0003045_fibrosis0.24292376
155MP0000604_amyloidosis0.23166114
156MP0005075_abnormal_melanosome_morpholog0.22464650
157MP0000432_abnormal_head_morphology0.19909690
158MP0001286_abnormal_eye_development0.19230477
159MP0002090_abnormal_vision0.19212859
160MP0002735_abnormal_chemical_nociception0.18416985
161MP0005367_renal/urinary_system_phenotyp0.16396522
162MP0000516_abnormal_urinary_system0.16396522
163MP0000733_abnormal_muscle_development0.14756152
164MP0003935_abnormal_craniofacial_develop0.14241365
165MP0004859_abnormal_synaptic_plasticity0.13521864
166MP0003300_gastrointestinal_ulcer0.12654508
167MP0000462_abnormal_digestive_system0.12107146
168MP0005257_abnormal_intraocular_pressure0.11832493
169MP0003136_yellow_coat_color0.11802382
170MP0008569_lethality_at_weaning0.11775307
171MP0000751_myopathy0.10177287
172MP0000049_abnormal_middle_ear0.09971413
173MP0001270_distended_abdomen0.09970422
174MP0005165_increased_susceptibility_to0.09848459
175MP0008961_abnormal_basal_metabolism0.09832745
176MP0002006_tumorigenesis0.09282843
177MP0000372_irregular_coat_pigmentation0.09273953
178MP0004019_abnormal_vitamin_homeostasis0.08980300
179MP0004036_abnormal_muscle_relaxation0.08901020
180MP0000538_abnormal_urinary_bladder0.08800261
181MP0002166_altered_tumor_susceptibility0.08238863
182MP0003950_abnormal_plasma_membrane0.07195354

Predicted human phenotypes

RankGene SetZ-score
1Brittle hair (HP:0002299)9.84873362
2Pili torti (HP:0003777)9.40724610
3Abnormality of the pubic bones (HP:0003172)6.95471711
4Nail dystrophy (HP:0008404)6.73351695
5Abnormal sex determination (HP:0012244)6.36428283
6Sex reversal (HP:0012245)6.36428283
7Hypoplastic scapulae (HP:0000882)6.14397509
8Aplasia/Hypoplasia of the scapulae (HP:0006713)6.14397509
9Dislocated radial head (HP:0003083)6.01957648
10Abnormal hair laboratory examination (HP:0003328)6.00104201
11Short humerus (HP:0005792)5.90964081
12Abnormality of the radial head (HP:0003995)5.80346325
13Abnormality of nail color (HP:0100643)5.68763163
14Periauricular skin pits (HP:0100277)5.50581112
15Preauricular pit (HP:0004467)5.50581112
16Aplasia/hypoplasia of the humerus (HP:0006507)5.42383772
17Fragile nails (HP:0001808)5.29685308
18Fine hair (HP:0002213)5.08910406
19Occipital encephalocele (HP:0002085)4.99312202
20Calcaneovalgus deformity (HP:0001848)4.98640782
21Rhabdomyosarcoma (HP:0002859)4.94649773
22Abnormality of the humeroradial joint (HP:0100744)4.90395967
23Increased IgE level (HP:0003212)4.87538020
24Follicular hyperkeratosis (HP:0007502)4.84893993
25Onycholysis (HP:0001806)4.82793821
26Palmoplantar hyperkeratosis (HP:0000972)4.71844581
27Alopecia of scalp (HP:0002293)4.59976794
28Neoplasm of striated muscle (HP:0009728)4.59234121
29Palmar hyperkeratosis (HP:0010765)4.44816758
30Deformed tarsal bones (HP:0008119)4.35485330
31Plantar hyperkeratosis (HP:0007556)4.29470452
32Erythema (HP:0010783)3.95947081
33Right ventricular cardiomyopathy (HP:0011663)3.94913815
34Thick nail (HP:0001805)3.89784046
35Skin pits (HP:0100276)3.80147551
36Short middle phalanx of the 5th finger (HP:0004220)3.68509026
37Renal salt wasting (HP:0000127)3.55481324
38Broad distal phalanx of finger (HP:0009836)3.51835740
39Sparse eyelashes (HP:0000653)3.48468258
40Ulnar claw (HP:0001178)3.36967938
41Hypotelorism (HP:0000601)3.34264487
42Testicular neoplasm (HP:0010788)3.26535069
43Amelogenesis imperfecta (HP:0000705)3.18548975
44Erythroderma (HP:0001019)3.16945899
45Abnormality of the frontal sinuses (HP:0002687)3.08479748
46Atresia of the external auditory canal (HP:0000413)3.06196007
47Parakeratosis (HP:0001036)3.05130687
48Abnormality of the humerus (HP:0003063)3.01507565
49Congenital, generalized hypertrichosis (HP:0004540)2.99627271
50Milia (HP:0001056)2.99207753
51Abnormality of the upper arm (HP:0001454)2.97946041
52Absent phalangeal crease (HP:0006109)2.91547749
53Curly hair (HP:0002212)2.87047360
54Poor suck (HP:0002033)2.86676305
55Abnormality of the 4th metacarpal (HP:0010012)2.80801830
56Gonadal dysgenesis (HP:0000133)2.76172714
57Broad metatarsal (HP:0001783)2.72243305
58Villous atrophy (HP:0011473)2.70835836
59Abnormality of small intestinal villus morphology (HP:0011472)2.70835836
60Oral leukoplakia (HP:0002745)2.70824475
61Hypoglycemic seizures (HP:0002173)2.70822598
62Gaze-evoked nystagmus (HP:0000640)2.68120790
63Neoplasm of the heart (HP:0100544)2.64368860
64Dysmetric saccades (HP:0000641)2.64142263
65Abnormality of the calcaneus (HP:0008364)2.63656429
66Abnormality of the distal phalanges of the toes (HP:0010182)2.59303521
67Type 2 muscle fiber atrophy (HP:0003554)2.59049979
68Nuclear cataract (HP:0100018)2.58393109
69Sensory axonal neuropathy (HP:0003390)2.57870613
70Congenital ichthyosiform erythroderma (HP:0007431)2.52007556
71Adrenal hypoplasia (HP:0000835)2.49208850
72Abnormal finger flexion creases (HP:0006143)2.48030662
73Thin bony cortex (HP:0002753)2.47962066
74Hemiparesis (HP:0001269)2.47268330
75Ridged nail (HP:0001807)2.46223953
76Aplasia cutis congenita (HP:0001057)2.42038061
77Abnormality of the phalanges of the hallux (HP:0010057)2.41838362
78Hyponatremia (HP:0002902)2.39725058
79Intention tremor (HP:0002080)2.39058183
80Zonular cataract (HP:0010920)2.33921570
81Renal dysplasia (HP:0000110)2.33794658
82Neck muscle weakness (HP:0000467)2.32921413
83Peripheral hypomyelination (HP:0007182)2.31867694
84Muscle fiber atrophy (HP:0100295)2.31552208
85Abnormal blistering of the skin (HP:0008066)2.28056284
86Hyperinsulinemic hypoglycemia (HP:0000825)2.27895966
87Corneal erosion (HP:0200020)2.20046896
88Natal tooth (HP:0000695)2.19649037
89Unilateral renal agenesis (HP:0000122)2.17436194
90Advanced eruption of teeth (HP:0006288)2.15286457
91Short 5th finger (HP:0009237)2.09851668
92Hyperphosphatemia (HP:0002905)2.07862871
93Hypohidrosis (HP:0000966)2.03425218
94Torticollis (HP:0000473)2.03067548
95Concave nail (HP:0001598)2.02268781
96Lymphangioma (HP:0100764)2.00117636
97Hypotrichosis (HP:0001006)14.0304016
98Woolly hair (HP:0002224)10.7795902
99Abnormality of hair growth rate (HP:0011363)10.5723902
100Slow-growing hair (HP:0002217)10.5723902
101Dry hair (HP:0011359)1.98838922
102Symptomatic seizures (HP:0011145)1.98602023
103Abnormality of the middle phalanges of the toes (HP:0010183)1.98138431
104Pruritus (HP:0000989)1.97727321
105Esophageal atresia (HP:0002032)1.97184891
106Cutaneous finger syndactyly (HP:0010554)1.96603154
107Abnormality of dental color (HP:0011073)1.96411792
108Nonprogressive disorder (HP:0003680)1.96142551
109Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.96106359
110Fetal akinesia sequence (HP:0001989)1.95209884
111Abnormality of sodium homeostasis (HP:0010931)1.93481247
112Palmoplantar keratoderma (HP:0000982)1.92769989
113Difficulty walking (HP:0002355)1.91681221
114Conjunctival hamartoma (HP:0100780)1.91207651
115Chin dimple (HP:0010751)1.90419225
116Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.90270966
117Abnormality of the aortic arch (HP:0012303)1.90031359
118Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.89834265
119Truncal ataxia (HP:0002078)1.89786706
120Corneal dystrophy (HP:0001131)1.86976922
121Akinesia (HP:0002304)1.86708297
122Aplasia/Hypoplasia of the clavicles (HP:0006710)1.85776400
123Abnormality of the parietal bone (HP:0002696)1.85410486
124Cutaneous syndactyly (HP:0012725)1.83652408
125Ventricular tachycardia (HP:0004756)1.82983660
126Weak cry (HP:0001612)1.82359049
127Amblyopia (HP:0000646)1.81480538
128Humeroradial synostosis (HP:0003041)1.81404395
129Synostosis involving the elbow (HP:0003938)1.81404395
130Limb dystonia (HP:0002451)1.80253570
131Abnormality of the fetal cardiovascular system (HP:0010948)1.80048383
132Abnormal umbilical cord blood vessels (HP:0011403)1.80048383
133Single umbilical artery (HP:0001195)1.80048383
134Postural tremor (HP:0002174)1.78443647
135Widely patent fontanelles and sutures (HP:0004492)1.77983713
136Symphalangism affecting the phalanges of the hand (HP:0009773)1.76723769
137Hypothermia (HP:0002045)1.76709098
138Abnormality of molar morphology (HP:0011070)1.76147828
139Abnormality of molar (HP:0011077)1.76147828
140Short clavicles (HP:0000894)1.74733785
141Bradycardia (HP:0001662)1.74682742
142Recurrent corneal erosions (HP:0000495)1.74332737
143Abnormality of the dental root (HP:0006486)1.73489808
144Taurodontia (HP:0000679)1.73489808
145Abnormality of permanent molar morphology (HP:0011071)1.73489808
146Abnormality of the pupil (HP:0000615)1.71209382
147Increased CSF protein (HP:0002922)1.70378518
148Congenital malformation of the right heart (HP:0011723)1.70276151
149Double outlet right ventricle (HP:0001719)1.70276151
150Hypoglycemic coma (HP:0001325)1.68935607
151Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.67470108
152Absent eyelashes (HP:0000561)1.67288402
153Segmental peripheral demyelination/remyelination (HP:0003481)1.66013285
154Tetany (HP:0001281)1.65966340
155Craniofacial dystonia (HP:0012179)1.64712720
156Hypomagnesemia (HP:0002917)1.64540743
157Azoospermia (HP:0000027)1.63890871
158Ventricular fibrillation (HP:0001663)1.60366355
159Hypergammaglobulinemia (HP:0010702)1.58080607
160Distal lower limb muscle weakness (HP:0009053)1.58073621
161Lip pit (HP:0100267)1.57398675
162Hyporeflexia of lower limbs (HP:0002600)1.50918753
163Focal dystonia (HP:0004373)1.50234304
164Abnormality of the dental pulp (HP:0006479)1.49628925
165Sudden death (HP:0001699)1.46311058
166Gangrene (HP:0100758)1.42723337
167Amniotic constriction ring (HP:0009775)1.41781872
168Abnormality of placental membranes (HP:0011409)1.41781872
169Hyperthyroidism (HP:0000836)1.39061614
170Acanthosis nigricans (HP:0000956)1.38831580
171Craniofacial hyperostosis (HP:0004493)1.38767299
172Widely spaced teeth (HP:0000687)1.35590128
173Carious teeth (HP:0000670)1.34308632
174Blepharitis (HP:0000498)1.32686932
175Type 1 muscle fiber predominance (HP:0003803)1.32251493
176Round ear (HP:0100830)1.29587249
177Heterogeneous (HP:0001425)1.28812925
178Ectropion (HP:0000656)1.27942604
179Achilles tendon contracture (HP:0001771)1.27330054
180Abnormality of the gastric mucosa (HP:0004295)1.26699081
181Abnormality of the neuromuscular junction (HP:0003398)1.25375788
182Fatigable weakness (HP:0003473)1.25375788
183Abnormality of the fingernails (HP:0001231)1.22591648
184Delusions (HP:0000746)1.21337834
185Atrophic scars (HP:0001075)1.20423141
186Distal lower limb amyotrophy (HP:0008944)1.19945387
187Abnormality of the Achilles tendon (HP:0005109)1.17690208
188Megalencephaly (HP:0001355)1.17243345
189Hamartoma of the eye (HP:0010568)1.15157269

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K64.63951997
2TEC3.98752395
3FER3.89991739
4FRK3.75098438
5EPHA23.43629575
6PNCK3.22709637
7EPHB23.10325248
8EPHA42.95433712
9MAPK152.90822162
10MAPKAPK32.65123858
11FGFR22.56686140
12DAPK22.44992403
13NTRK32.38677932
14ERN12.38495188
15BRSK22.36807963
16CAMK1G2.36206239
17TAOK12.34400629
18SIK12.31320274
19MAP3K22.25949314
20LATS12.24063442
21OBSCN2.19766028
22CAMKK22.12721618
23MAP3K32.02137605
24MAP2K61.77108203
25PIK3CG1.76159814
26NTRK11.72481639
27MST41.68608844
28FGFR11.61933683
29PDGFRA1.57503661
30MST1R1.55273678
31MAP3K101.53617519
32LATS21.53023630
33TTN1.47804023
34TRIB31.45190573
35CDK61.43806493
36MAP2K41.43330254
37SIK21.32083373
38NLK1.26204691
39CSNK1A1L1.24551844
40PASK1.21178094
41MAP3K111.21136620
42RPS6KB21.18483815
43DYRK1A1.18375206
44BMPR21.15667106
45BCR1.14493413
46EPHB11.13636946
47NTRK21.12103249
48PAK31.10371212
49BLK1.05215549
50MAP3K71.05064721
51STK391.04857925
52FGFR31.02026324
53BMX1.00121872
54BRSK10.99466541
55NME10.99345535
56MARK10.98564549
57PTK20.96857774
58KSR20.94911406
59RPS6KA20.93705818
60FGFR40.93181784
61EIF2AK20.91127916
62MARK20.91028747
63MKNK20.90266402
64RPS6KC10.88464342
65RPS6KL10.88464342
66MAP3K10.87227256
67MAPKAPK20.86186894
68HIPK20.85340867
69CSNK1G10.84932404
70PRKAA20.84035172
71RPS6KA60.83498704
72CSNK1G30.82829092
73EEF2K0.81597980
74JAK10.79539747
75ACVR1B0.77455734
76SGK10.74380521
77PRKCI0.73802546
78CDC42BPA0.73571826
79RPS6KA40.73221362
80RET0.72441729
81FGR0.70959374
82TYRO30.69894876
83CAMKK10.69000005
84IRAK10.68567628
85PBK0.68462963
86MAP3K50.68387455
87PKN10.67627181
88ALK0.66522073
89MAP3K90.64463686
90PIK3CA0.63854916
91PAK60.63808535
92PRKCG0.63584684
93PRKAA10.62748497
94DMPK0.62504568
95MET0.62096808
96RIPK40.59369132
97MINK10.59250489
98MAP2K10.58739748
99IKBKE0.58494484
100STK30.56930621
101PRKCE0.56784896
102CAMK10.55938413
103TYK20.55430861
104WNK40.55369894
105MAP2K20.54690704
106CHUK0.54505667
107NEK60.53785736
108MAPK70.53641597
109STK380.53588018
110BRD40.53168549
111CSNK1E0.51495485
112PRKD10.51273450
113ROCK20.49796021
114RIPK10.49446743
115CASK0.48843809
116IKBKB0.47126612
117DDR20.46749333
118WNK10.46720226
119PTK60.45803140
120RPS6KA10.45745059
121CSNK1G20.44030846
122PRKCZ0.41704629
123RPS6KB10.41582216
124MAP2K30.41514531
125DAPK10.40823025
126CDK190.40427140
127GRK10.38773794
128MTOR0.38702590
129CAMK2G0.37158809
130DYRK1B0.36882835
131CAMK2A0.36564502
132PLK20.36126389
133MAPK10.35962749
134LIMK10.34545436
135MAPK120.33940436
136EPHA30.33511701
137CAMK1D0.31894258
138PRKCH0.31648632
139MAP3K40.31485490
140UHMK10.30482371
141DYRK20.30438957
142ERBB20.29842524
143CDK50.29140131
144GSK3A0.28524358
145PHKG10.28322090
146PHKG20.28322090
147FYN0.28309364
148STK110.28300606
149ERBB40.27612659
150STK38L0.27421622
151PRKACG0.27246093
152PRKACA0.27240826
153TNIK0.27107220
154LRRK20.25693192
155RPS6KA50.25205300
156PDPK10.24553783
157PDGFRB0.24021959
158MKNK10.24013732
159SRC0.23426625
160CDK30.23265103
161PIM20.23172959
162FES0.22948355
163TESK10.22680434
164TRPM70.22606919
165KSR10.22292213
166INSRR0.21586503

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049508.25451517
2Linoleic acid metabolism_Homo sapiens_hsa005913.65012482
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.62672756
4Other glycan degradation_Homo sapiens_hsa005113.32604174
5Tryptophan metabolism_Homo sapiens_hsa003803.06311316
6Sphingolipid metabolism_Homo sapiens_hsa006002.66609841
7Circadian rhythm_Homo sapiens_hsa047102.43177211
8Fatty acid elongation_Homo sapiens_hsa000622.36447798
9Fat digestion and absorption_Homo sapiens_hsa049752.25318902
10Ether lipid metabolism_Homo sapiens_hsa005652.16659357
11mTOR signaling pathway_Homo sapiens_hsa041502.12381483
12Long-term potentiation_Homo sapiens_hsa047201.89503636
13Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.88971735
14Basal cell carcinoma_Homo sapiens_hsa052171.88812619
15Axon guidance_Homo sapiens_hsa043601.87276791
16VEGF signaling pathway_Homo sapiens_hsa043701.86735269
17Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.83688808
18Glioma_Homo sapiens_hsa052141.83506279
19Melanogenesis_Homo sapiens_hsa049161.76753556
20Dorso-ventral axis formation_Homo sapiens_hsa043201.63097973
21Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.61629583
22Butanoate metabolism_Homo sapiens_hsa006501.60924515
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.52424213
24Mineral absorption_Homo sapiens_hsa049781.46655121
25Insulin secretion_Homo sapiens_hsa049111.44495622
26Vascular smooth muscle contraction_Homo sapiens_hsa042701.39194074
27Regulation of autophagy_Homo sapiens_hsa041401.37571950
28Bladder cancer_Homo sapiens_hsa052191.34158332
29GnRH signaling pathway_Homo sapiens_hsa049121.31653982
30Lysine degradation_Homo sapiens_hsa003101.31639575
31Phenylalanine metabolism_Homo sapiens_hsa003601.29835266
32Cocaine addiction_Homo sapiens_hsa050301.28589019
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.25163653
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24071999
35Arachidonic acid metabolism_Homo sapiens_hsa005901.23559452
36Estrogen signaling pathway_Homo sapiens_hsa049151.20013078
37Hedgehog signaling pathway_Homo sapiens_hsa043401.18501088
38Pancreatic secretion_Homo sapiens_hsa049721.17106835
39Thyroid cancer_Homo sapiens_hsa052161.14163984
40Salivary secretion_Homo sapiens_hsa049701.13635879
41Proteoglycans in cancer_Homo sapiens_hsa052051.12609590
42Long-term depression_Homo sapiens_hsa047301.11407419
43Histidine metabolism_Homo sapiens_hsa003401.11331268
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.10252164
45Adherens junction_Homo sapiens_hsa045201.09556890
46Hippo signaling pathway_Homo sapiens_hsa043901.07183443
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04124898
48Tight junction_Homo sapiens_hsa045301.03985553
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.03149445
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02569746
51Renin secretion_Homo sapiens_hsa049241.01858662
52Amphetamine addiction_Homo sapiens_hsa050311.00859643
53PPAR signaling pathway_Homo sapiens_hsa033200.98512050
54Wnt signaling pathway_Homo sapiens_hsa043100.98020134
55Oxytocin signaling pathway_Homo sapiens_hsa049210.95554430
56Ras signaling pathway_Homo sapiens_hsa040140.92540107
57ECM-receptor interaction_Homo sapiens_hsa045120.91676450
58Gastric acid secretion_Homo sapiens_hsa049710.91649720
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.91316718
60Acute myeloid leukemia_Homo sapiens_hsa052210.90505092
61Non-small cell lung cancer_Homo sapiens_hsa052230.89820262
62Retinol metabolism_Homo sapiens_hsa008300.89692753
63Type II diabetes mellitus_Homo sapiens_hsa049300.88614321
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.88195236
65Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.85356835
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.84929633
67Circadian entrainment_Homo sapiens_hsa047130.84454931
68Non-homologous end-joining_Homo sapiens_hsa034500.83889978
69Dopaminergic synapse_Homo sapiens_hsa047280.83801281
70AMPK signaling pathway_Homo sapiens_hsa041520.82305216
71Steroid biosynthesis_Homo sapiens_hsa001000.82194596
72Salmonella infection_Homo sapiens_hsa051320.81833771
73Phototransduction_Homo sapiens_hsa047440.81541845
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81226051
75Pertussis_Homo sapiens_hsa051330.80116627
76Fatty acid metabolism_Homo sapiens_hsa012120.77506228
77ErbB signaling pathway_Homo sapiens_hsa040120.76749087
78N-Glycan biosynthesis_Homo sapiens_hsa005100.76558570
79Gap junction_Homo sapiens_hsa045400.75941630
80Endometrial cancer_Homo sapiens_hsa052130.74936251
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74844877
82Tyrosine metabolism_Homo sapiens_hsa003500.74411974
83ABC transporters_Homo sapiens_hsa020100.73761089
84Amoebiasis_Homo sapiens_hsa051460.70196857
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.70196136
86Fatty acid degradation_Homo sapiens_hsa000710.70152639
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69356215
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.68898069
89GABAergic synapse_Homo sapiens_hsa047270.67853323
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67725807
91Caffeine metabolism_Homo sapiens_hsa002320.67669161
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66532497
93Insulin signaling pathway_Homo sapiens_hsa049100.66410592
94AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66133397
95Glutamatergic synapse_Homo sapiens_hsa047240.65953467
96Fructose and mannose metabolism_Homo sapiens_hsa000510.65180327
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.64519234
98Glucagon signaling pathway_Homo sapiens_hsa049220.64423439
99Olfactory transduction_Homo sapiens_hsa047400.64352461
100Nitrogen metabolism_Homo sapiens_hsa009100.64095666
101Focal adhesion_Homo sapiens_hsa045100.63506223
102Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63373580
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.63295436
104Calcium signaling pathway_Homo sapiens_hsa040200.62957029
105Prolactin signaling pathway_Homo sapiens_hsa049170.62855743
106Primary bile acid biosynthesis_Homo sapiens_hsa001200.61509368
107Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61337598
108cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60836471
109TGF-beta signaling pathway_Homo sapiens_hsa043500.60443391
110Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.60287427
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59011899
112Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58915668
113FoxO signaling pathway_Homo sapiens_hsa040680.58533106
114Rap1 signaling pathway_Homo sapiens_hsa040150.57860565
115Nicotine addiction_Homo sapiens_hsa050330.57552733
116Ovarian steroidogenesis_Homo sapiens_hsa049130.57440080
117beta-Alanine metabolism_Homo sapiens_hsa004100.57396222
118Shigellosis_Homo sapiens_hsa051310.56851629
119Protein digestion and absorption_Homo sapiens_hsa049740.56581821
120MicroRNAs in cancer_Homo sapiens_hsa052060.55830955
121Tuberculosis_Homo sapiens_hsa051520.55784909
122Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54913001
123Cholinergic synapse_Homo sapiens_hsa047250.54630028
124Staphylococcus aureus infection_Homo sapiens_hsa051500.54565700
125Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54171618
126Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54068866
127cAMP signaling pathway_Homo sapiens_hsa040240.54055560
128Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53423143
129Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52570259
130Hepatitis C_Homo sapiens_hsa051600.52036790
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51833104
132Platelet activation_Homo sapiens_hsa046110.51479237
133Serotonergic synapse_Homo sapiens_hsa047260.51158594
134Chronic myeloid leukemia_Homo sapiens_hsa052200.51138790
135Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50225680
136Notch signaling pathway_Homo sapiens_hsa043300.49355776
137Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48437699
138Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47724066
139Insulin resistance_Homo sapiens_hsa049310.47644675
140Fatty acid biosynthesis_Homo sapiens_hsa000610.47375878
141Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47211725
142Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46733021
143Prion diseases_Homo sapiens_hsa050200.46702390
144Melanoma_Homo sapiens_hsa052180.46282674
145Morphine addiction_Homo sapiens_hsa050320.45206494
146Propanoate metabolism_Homo sapiens_hsa006400.43683777
147Renal cell carcinoma_Homo sapiens_hsa052110.43641326
148Choline metabolism in cancer_Homo sapiens_hsa052310.43262467
149Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41054448
150Steroid hormone biosynthesis_Homo sapiens_hsa001400.30618774
151Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30220959

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