KRT34

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1adhesion of symbiont to host cell (GO:0044650)9.92750401
2virion attachment to host cell (GO:0019062)9.92750401
3citrulline biosynthetic process (GO:0019240)8.88548929
4peptide cross-linking (GO:0018149)8.49369321
5hair follicle morphogenesis (GO:0031069)8.40709992
6adhesion of symbiont to host (GO:0044406)8.38579979
7hypotonic response (GO:0006971)7.59754118
8positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)7.22124462
9regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)7.22124462
10intermediate filament cytoskeleton organization (GO:0045104)6.70963061
11endodermal cell differentiation (GO:0035987)6.51424545
12intermediate filament-based process (GO:0045103)6.49587771
13cell adhesion mediated by integrin (GO:0033627)6.43084885
14cell wall macromolecule catabolic process (GO:0016998)6.04530492
15cell wall macromolecule metabolic process (GO:0044036)6.04530492
16establishment of skin barrier (GO:0061436)5.95192207
17citrulline metabolic process (GO:0000052)5.88798308
18keratinocyte differentiation (GO:0030216)5.76757468
19* epidermis development (GO:0008544)5.60272794
20molting cycle process (GO:0022404)5.38418504
21hair cycle process (GO:0022405)5.38418504
22substrate-dependent cell migration (GO:0006929)5.30000008
23regulation of water loss via skin (GO:0033561)5.26948528
24bundle of His cell to Purkinje myocyte communication (GO:0086069)5.02433192
25peptidyl-arginine modification (GO:0018195)4.91237937
26hemidesmosome assembly (GO:0031581)4.84115219
27protein heterotrimerization (GO:0070208)4.78784819
28skin morphogenesis (GO:0043589)4.74772826
29collagen fibril organization (GO:0030199)4.67548135
30type B pancreatic cell proliferation (GO:0044342)4.53585755
31epidermal cell differentiation (GO:0009913)4.48828276
32regulation of transforming growth factor beta1 production (GO:0032908)4.20136332
33chondrocyte proliferation (GO:0035988)4.07921646
34mesodermal cell differentiation (GO:0048333)4.06203448
35regulation of MHC class I biosynthetic process (GO:0045343)4.00401529
36molting cycle (GO:0042303)35.1013429
37hair cycle (GO:0042633)35.1013429
38natural killer cell activation involved in immune response (GO:0002323)3.98730164
39tooth mineralization (GO:0034505)3.80711237
40keratinocyte development (GO:0003334)3.76867882
41positive regulation of blood vessel endothelial cell migration (GO:0043536)3.71413179
42extracellular matrix assembly (GO:0085029)3.66426838
43regulation of plasminogen activation (GO:0010755)3.66052048
44negative regulation of nitric-oxide synthase activity (GO:0051001)3.54347938
45multicellular organismal water homeostasis (GO:0050891)3.53629508
46cell migration involved in heart development (GO:0060973)3.47920882
47regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.44400872
48phosphatidylinositol acyl-chain remodeling (GO:0036149)3.42490889
49cellular response to vitamin (GO:0071295)3.42062033
50extracellular matrix disassembly (GO:0022617)3.39550214
51kidney mesenchyme development (GO:0072074)3.35938058
52regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.33213875
53regulation of keratinocyte differentiation (GO:0045616)3.31031323
54negative regulation of keratinocyte proliferation (GO:0010839)3.30913167
55sequestering of extracellular ligand from receptor (GO:0035581)3.29249734
56regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.27303801
57endocardial cushion development (GO:0003197)3.26627860
58focal adhesion assembly (GO:0048041)3.23913328
59cell-substrate adherens junction assembly (GO:0007045)3.23913328
60mesenchymal-epithelial cell signaling (GO:0060638)3.22236785
61membrane raft organization (GO:0031579)3.21062403
62positive regulation of hair follicle development (GO:0051798)3.18925950
63positive regulation of hair cycle (GO:0042635)3.18925950
64hair follicle development (GO:0001942)3.15491498
65negative regulation of establishment of protein localization to plasma membrane (GO:0090005)3.15418318
66negative regulation of fatty acid transport (GO:2000192)3.14421166
67phosphatidylserine acyl-chain remodeling (GO:0036150)3.13945956
68negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.10588653
69collagen metabolic process (GO:0032963)3.09924218
70negative regulation of chondrocyte differentiation (GO:0032331)3.04644527
71positive regulation of collagen biosynthetic process (GO:0032967)3.04001524
72smooth muscle tissue development (GO:0048745)3.02507178
73adherens junction assembly (GO:0034333)3.00943587
74negative regulation of smooth muscle cell migration (GO:0014912)2.98312325
75regulation of hair follicle development (GO:0051797)2.97744265
76collagen catabolic process (GO:0030574)2.97359816
77positive regulation of endothelial cell apoptotic process (GO:2000353)2.93365763
78heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.92281654
79bone trabecula formation (GO:0060346)2.90815189
80cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.89975961
81phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.89967005
82cellular response to vitamin D (GO:0071305)2.89942762
83water homeostasis (GO:0030104)2.89829115
84stress fiber assembly (GO:0043149)2.86700686
85cell migration involved in sprouting angiogenesis (GO:0002042)2.86019134
86positive regulation of collagen metabolic process (GO:0010714)2.85409855
87establishment of epithelial cell polarity (GO:0090162)2.84881386
88multicellular organismal macromolecule metabolic process (GO:0044259)2.83090154
89wound healing (GO:0042060)2.81099663
90endothelial cell morphogenesis (GO:0001886)2.79985697
91negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.77509454
92protein localization to endosome (GO:0036010)2.76351258
93extracellular matrix organization (GO:0030198)2.75554301
94endocytic recycling (GO:0032456)2.75511437
95cell junction assembly (GO:0034329)2.75055047
96hyaluronan catabolic process (GO:0030214)2.74937048
97extracellular structure organization (GO:0043062)2.74530425
98regulation of collagen metabolic process (GO:0010712)2.72504359
99regulation of metalloenzyme activity (GO:0048552)2.71811789
100gap junction assembly (GO:0016264)2.71702847
101multicellular organismal metabolic process (GO:0044236)2.69813689
102multicellular organismal catabolic process (GO:0044243)2.68892033
103positive regulation of epidermis development (GO:0045684)2.68801186
104muscle cell migration (GO:0014812)2.68492416
105positive regulation of meiotic cell cycle (GO:0051446)2.67909800
106ectoderm development (GO:0007398)2.65402581
107positive regulation of fibroblast migration (GO:0010763)2.65350923
108* epithelium development (GO:0060429)2.65074228
109regulation of hair cycle (GO:0042634)2.64930388
110metanephric mesenchyme development (GO:0072075)2.63987057
111COPI coating of Golgi vesicle (GO:0048205)2.63867034
112Golgi transport vesicle coating (GO:0048200)2.63867034
113extracellular fibril organization (GO:0043206)2.62929491
114negative regulation of protein localization to plasma membrane (GO:1903077)2.61068002
115regulation of collagen biosynthetic process (GO:0032965)2.60905548
116blood vessel maturation (GO:0001955)2.59938362
117negative regulation of anoikis (GO:2000811)2.58140207
118positive regulation of positive chemotaxis (GO:0050927)2.57135935
119regulation of epidermal cell differentiation (GO:0045604)2.56616376
120response to magnesium ion (GO:0032026)2.56015621
121atrioventricular valve morphogenesis (GO:0003181)2.55061821
122sprouting angiogenesis (GO:0002040)2.54820314
123fatty acid elongation (GO:0030497)2.50476398
124regulation of epidermis development (GO:0045682)2.46939934
125epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.37321908
126phosphatidylserine metabolic process (GO:0006658)2.36478417
127ventricular cardiac muscle cell action potential (GO:0086005)2.33895672
128phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.29372208
129negative regulation of cell fate specification (GO:0009996)2.25242014
130wound healing, spreading of epidermal cells (GO:0035313)2.21523222
131positive regulation of epidermal cell differentiation (GO:0045606)2.19900766
132skin development (GO:0043588)2.16963641
133cell surface receptor signaling pathway involved in heart development (GO:0061311)2.16714731
134positive regulation of monocyte chemotaxis (GO:0090026)2.16210699
135regulation of mesenchymal cell apoptotic process (GO:2001053)2.15747261
136lymph vessel development (GO:0001945)2.09501771
137cranial suture morphogenesis (GO:0060363)2.09112186
138aging (GO:0007568)2.08050041
139phosphatidylcholine acyl-chain remodeling (GO:0036151)2.02666375
140intermediate filament organization (GO:0045109)12.2341053
141keratinization (GO:0031424)11.8003579
142desmosome organization (GO:0002934)10.0103751
143regulation of ruffle assembly (GO:1900027)1.99894991
144regulation of cardioblast differentiation (GO:0051890)1.98680864
145epithelial cell-cell adhesion (GO:0090136)1.97823465
146cytoskeletal anchoring at plasma membrane (GO:0007016)1.95744684
147regulation of heart rate by cardiac conduction (GO:0086091)1.95022558
148myotube differentiation (GO:0014902)1.94879231
149outflow tract septum morphogenesis (GO:0003148)1.92480156
150negative regulation of epidermis development (GO:0045683)1.92100888
151planar cell polarity pathway involved in neural tube closure (GO:0090179)1.90247262
152cell communication involved in cardiac conduction (GO:0086065)1.85102255
153regulation of keratinocyte proliferation (GO:0010837)1.84700366
154regulation of Wnt signaling pathway involved in heart development (GO:0003307)1.83701415
155ephrin receptor signaling pathway (GO:0048013)1.83464482
156cell-substrate junction assembly (GO:0007044)1.77534753
157non-canonical Wnt signaling pathway (GO:0035567)1.75763405
158regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)1.75060211
159alditol phosphate metabolic process (GO:0052646)1.74931482
160keratinocyte proliferation (GO:0043616)1.73821352
161primary alcohol catabolic process (GO:0034310)1.65479815
162coronary vasculature morphogenesis (GO:0060977)1.63293830
163antigen processing and presentation of endogenous peptide antigen (GO:0002483)1.62675285
164antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)1.62675285
165regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901211.61019007
166very long-chain fatty acid metabolic process (GO:0000038)1.60622680
167regulation of cardioblast proliferation (GO:0003264)1.59485077
168regulation of secondary heart field cardioblast proliferation (GO:0003266)1.59485077
169establishment of planar polarity (GO:0001736)1.56701764
170establishment of tissue polarity (GO:0007164)1.56701764
171wound healing, spreading of cells (GO:0044319)1.55686891
172regulation of monocyte chemotaxis (GO:0090025)1.54835195
173cellular modified amino acid biosynthetic process (GO:0042398)1.53920580
174response to UV-B (GO:0010224)1.53744902

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.37601032
2CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.92236959
3P63_26484246_Chip-Seq_KERATINOCYTES_Human3.59585636
4BRD4_25478319_ChIP-Seq_HGPS_Human2.89263957
5SMAD_19615063_ChIP-ChIP_OVARY_Human2.78253018
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.61824716
7CJUN_26792858_Chip-Seq_BT549_Human2.35406900
8WT1_19549856_ChIP-ChIP_CCG9911_Human2.29612227
9* CTCF_20526341_ChIP-Seq_ESCs_Human2.24519640
10BMI1_19503595_ChIP-Seq_MEFsC_Mouse2.18900371
11NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse2.15414770
12CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.00610853
13TP63_17297297_ChIP-ChIP_HaCaT_Human12.5869949
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.92698023
15E2F1_20622854_ChIP-Seq_HELA_Human1.88741393
16VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.77387872
17P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.76140745
18NANOG_20526341_ChIP-Seq_ESCs_Human1.74205091
19CLOCK_20551151_ChIP-Seq_293T_Human1.73846474
20HIF1A_21447827_ChIP-Seq_MCF-7_Human1.72468532
21EGR1_19032775_ChIP-ChIP_M12_Human1.71579328
22ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.71350127
23* TAF2_19829295_ChIP-Seq_ESCs_Human1.70671626
24SOX9_24532713_ChIP-Seq_HFSC_Mouse1.68903953
25CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.67180833
26ERG_20517297_ChIP-Seq_VCAP_Human1.66172650
27TP53_16413492_ChIP-PET_HCT116_Human1.65737046
28SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.65554843
29CTCF_27219007_Chip-Seq_Bcells_Human1.62979203
30* CSB_26484114_Chip-Seq_FIBROBLAST_Human1.59960089
31NRF2_20460467_ChIP-Seq_MEFs_Mouse1.59868251
32NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.59868251
33ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.55865103
34BCL6_27268052_Chip-Seq_Bcells_Human1.54173494
35FOXO3_23340844_ChIP-Seq_DLD1_Human1.53715237
36WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.52819154
37PPAR_26484153_Chip-Seq_NCI-H1993_Human1.52336841
38TP53_20018659_ChIP-ChIP_R1E_Mouse1.52194872
39YY1_22570637_ChIP-Seq_MALME-3M_Human1.51582179
40RACK7_27058665_Chip-Seq_MCF-7_Human1.51553248
41LXR_22292898_ChIP-Seq_THP-1_Human1.50502137
42SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.50448331
43SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.50448331
44TP53_22127205_ChIP-Seq_IMR90_Human1.50274628
45DNAJC2_21179169_ChIP-ChIP_NT2_Human1.50037767
46MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.47839510
47* P53_21459846_ChIP-Seq_SAOS-2_Human1.46979212
48BCOR_27268052_Chip-Seq_Bcells_Human1.46064682
49GATA2_21666600_ChIP-Seq_HMVEC_Human1.45173058
50AR_21909140_ChIP-Seq_LNCAP_Human1.44680715
51* TP63_22573176_ChIP-Seq_HFKS_Human1.44406090
52ATF3_27146783_Chip-Seq_COLON_Human1.38082655
53ESR1_21235772_ChIP-Seq_MCF-7_Human1.37721909
54ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.37315331
55CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.36209312
56RARG_19884340_ChIP-ChIP_MEFs_Mouse1.35579206
57FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.34619453
58SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.29954593
59EP300_21415370_ChIP-Seq_HL-1_Mouse1.28697349
60PHF8_20622854_ChIP-Seq_HELA_Human1.28667932
61ESR2_21235772_ChIP-Seq_MCF-7_Human1.27593159
62ARNT_22903824_ChIP-Seq_MCF-7_Human1.26018078
63SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.25366178
64P68_20966046_ChIP-Seq_HELA_Human1.24436132
65AHR_22903824_ChIP-Seq_MCF-7_Human1.23963394
66* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.23273723
67ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22958983
68ELF1_20517297_ChIP-Seq_JURKAT_Human1.22950617
69KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22888396
70CEBPB_22108803_ChIP-Seq_LS180_Human1.18567187
71SMC1_22415368_ChIP-Seq_MEFs_Mouse1.18517544
72SUZ12_27294783_Chip-Seq_ESCs_Mouse1.17803095
73KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17730588
74E2F1_17053090_ChIP-ChIP_MCF-7_Human1.17328770
75TRIM28_21343339_ChIP-Seq_HEK293_Human1.16609994
76PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.16134336
77ELK4_26923725_Chip-Seq_MESODERM_Mouse1.14746773
78IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13666778
79RAC3_21632823_ChIP-Seq_H3396_Human1.13576316
80JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12275248
81SMC4_20622854_ChIP-Seq_HELA_Human1.10910933
82GATA3_24758297_ChIP-Seq_MCF-7_Human1.10464563
83TP63_23658742_ChIP-Seq_EP156T_Human1.10048827
84TP53_23651856_ChIP-Seq_MEFs_Mouse1.09826627
85JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08129212
86UBF1/2_26484160_Chip-Seq_HMECs_Human1.06697703
87P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06518376
88GATA4_25053715_ChIP-Seq_YYC3_Human1.05520000
89TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05233380
90EED_16625203_ChIP-ChIP_MESCs_Mouse1.04644786
91SOX2_21211035_ChIP-Seq_LN229_Human1.04643666
92JARID2_20075857_ChIP-Seq_MESCs_Mouse1.04126991
93SA1_27219007_Chip-Seq_ERYTHROID_Human1.03428130
94SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01698082
95EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.00943351
96GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.00583910
97EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99703035
98RXRA_24833708_ChIP-Seq_LIVER_Mouse0.98894228
99RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98889293
100FOXH1_21741376_ChIP-Seq_ESCs_Human0.96809022
101KLF5_25053715_ChIP-Seq_YYC3_Human0.96604912
102EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.96485405
103ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.96096599
104TP53_18474530_ChIP-ChIP_U2OS_Human0.95882689
105FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.94982615
106SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93941804
107TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93370523
108CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.93168667
109TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92564516
110NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92474232
111ERG_21242973_ChIP-ChIP_JURKAT_Human0.91819648
112SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.91771140
113GATA6_21074721_ChIP-Seq_CACO-2_Human0.91514299
114Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.90810972
115SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.88894425
116SMC3_22415368_ChIP-Seq_MEFs_Mouse0.88398109
117TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.88045431
118RING1B_27294783_Chip-Seq_ESCs_Mouse0.87247333
119RXR_22108803_ChIP-Seq_LS180_Human0.87116092
120RUNX1_27514584_Chip-Seq_MCF-7_Human0.86758598
121GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.86740455
122TBX20_22328084_ChIP-Seq_HEART_Mouse0.86060597
123TBX20_22080862_ChIP-Seq_HEART_Mouse0.86060597
124ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.85408988
125SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.85396249
126SA1_22415368_ChIP-Seq_MEFs_Mouse0.85344592
127RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.85207386
128SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.84048939
129NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.83498188
130SOX2_20726797_ChIP-Seq_SW620_Human0.82345852
131KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.80838055
132ZNF263_19887448_ChIP-Seq_K562_Human0.80689014
133CDX2_19796622_ChIP-Seq_MESCs_Mouse0.80157922
134PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.79773808
135RNF2_27304074_Chip-Seq_ESCs_Mouse0.79734073
136EZH2_27294783_Chip-Seq_ESCs_Mouse0.77882632
137TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.77536806
138* SPI1_20517297_ChIP-Seq_HL60_Human0.77488623
139ZFP281_18757296_ChIP-ChIP_E14_Mouse0.77395506
140MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.76752027
141ELK3_25401928_ChIP-Seq_HUVEC_Human0.75781619
142AR_21572438_ChIP-Seq_LNCaP_Human0.75547437
143KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.75196515
144FOXA1_27270436_Chip-Seq_PROSTATE_Human0.74771878
145FOXA1_25329375_ChIP-Seq_VCAP_Human0.74771878
146VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.73642025
147EZH2_18974828_ChIP-Seq_MESCs_Mouse0.73015087
148RNF2_18974828_ChIP-Seq_MESCs_Mouse0.73015087
149NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.72200089
150MYB_21317192_ChIP-Seq_ERMYB_Mouse0.71755944
151PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.71494915
152HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.70205840
153POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.68528915
154PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.68504733
155ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.68348722
156TCF4_18268006_ChIP-ChIP_LS174T_Human0.67236798
157PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.67030404
158SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.66656199

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology7.58630912
2MP0002098_abnormal_vibrissa_morphology7.24379984
3MP0000647_abnormal_sebaceous_gland6.45016961
4MP0002796_impaired_skin_barrier5.91308236
5MP0005275_abnormal_skin_tensile5.18563046
6MP0010234_abnormal_vibrissa_follicle5.14518441
7MP0000383_abnormal_hair_follicle4.48444450
8MP0000377_abnormal_hair_follicle4.08572296
9MP0010678_abnormal_skin_adnexa3.98294277
10MP0003705_abnormal_hypodermis_morpholog3.76352978
11MP0005501_abnormal_skin_physiology3.70310259
12MP0000427_abnormal_hair_cycle3.45109667
13MP0005503_abnormal_tendon_morphology3.26695614
14MP0002254_reproductive_system_inflammat3.04640354
15MP0003279_aneurysm2.89375217
16MP0001216_abnormal_epidermal_layer2.67393576
17MP0004381_abnormal_hair_follicle2.52758301
18MP0010368_abnormal_lymphatic_system2.47688499
19MP0001542_abnormal_bone_strength2.45304469
20MP0005257_abnormal_intraocular_pressure2.42532898
21MP0000367_abnormal_coat/_hair2.39060757
22MP0010771_integument_phenotype2.31315515
23MP0004947_skin_inflammation2.29492271
24MP0002060_abnormal_skin_morphology2.20290290
25MP0009780_abnormal_chondrocyte_physiolo2.18330157
26MP0003453_abnormal_keratinocyte_physiol2.16987782
27MP0001243_abnormal_dermal_layer2.14425313
28MP0002234_abnormal_pharynx_morphology2.05042440
29MP0005623_abnormal_meninges_morphology1.79470914
30MP0000467_abnormal_esophagus_morphology1.73384860
31MP0001348_abnormal_lacrimal_gland1.56442228
32MP0003091_abnormal_cell_migration1.52882628
33MP0009053_abnormal_anal_canal1.52312721
34MP0009931_abnormal_skin_appearance1.51705784
35MP0000762_abnormal_tongue_morphology1.48979424
36MP0003566_abnormal_cell_adhesion1.46039578
37MP0001299_abnormal_eye_distance/1.36652790
38MP0000767_abnormal_smooth_muscle1.35409493
39MP0005508_abnormal_skeleton_morphology1.28993927
40MP0005409_darkened_coat_color1.25904289
41MP0002295_abnormal_pulmonary_circulatio1.24963782
42MP0003941_abnormal_skin_development1.22945822
43MP0000538_abnormal_urinary_bladder1.20781213
44MP0002896_abnormal_bone_mineralization1.13158053
45MP0009250_abnormal_appendicular_skeleto1.03666333
46MP0001191_abnormal_skin_condition0.99209250
47MP0000534_abnormal_ureter_morphology0.94437410
48MP0004885_abnormal_endolymph0.94297758
49MP0004185_abnormal_adipocyte_glucose0.91150795
50MP0008438_abnormal_cutaneous_collagen0.89658227
51MP0005595_abnormal_vascular_smooth0.88203137
52MP0004264_abnormal_extraembryonic_tissu0.85345689
53MP0002095_abnormal_skin_pigmentation0.84754984
54MP0001851_eye_inflammation0.78409796
55MP0005197_abnormal_uvea_morphology0.74409169
56MP0005164_abnormal_response_to0.73672305
57MP0002108_abnormal_muscle_morphology0.72003584
58MP0000003_abnormal_adipose_tissue0.70824247
59MP0005390_skeleton_phenotype0.69756094
60MP0005360_urolithiasis0.69727913
61MP0003315_abnormal_perineum_morphology0.68768155
62MP0000858_altered_metastatic_potential0.67669463
63MP0001849_ear_inflammation0.65748830
64MP0002877_abnormal_melanocyte_morpholog0.63781187
65MP0000163_abnormal_cartilage_morphology0.63465797
66MP0001340_abnormal_eyelid_morphology0.63351494
67MP0010386_abnormal_urinary_bladder0.63303048
68MP0001346_abnormal_lacrimal_gland0.61568749
69MP0010030_abnormal_orbit_morphology0.61493247
70MP0000759_abnormal_skeletal_muscle0.60821572
71MP0000569_abnormal_digit_pigmentation0.60654852
72MP0003191_abnormal_cellular_cholesterol0.60146454
73MP0000566_synostosis0.58569499
74MP0001661_extended_life_span0.58192638
75MP0000627_abnormal_mammary_gland0.55357197
76MP0000428_abnormal_craniofacial_morphol0.54784761
77MP0004233_abnormal_muscle_weight0.53554220
78MP0003942_abnormal_urinary_system0.52574459
79MP0009379_abnormal_foot_pigmentation0.52067308
80MP0005451_abnormal_body_composition0.51766195
81MP0003795_abnormal_bone_structure0.51279634
82MP0002115_abnormal_skeleton_extremities0.51055590
83MP0002282_abnormal_trachea_morphology0.50665124
84MP0004134_abnormal_chest_morphology0.50201958
85MP0000750_abnormal_muscle_regeneration0.49182612
86MP0003755_abnormal_palate_morphology0.48675117
87MP0005023_abnormal_wound_healing0.48598650
88MP0003828_pulmonary_edema0.46529694
89MP0002970_abnormal_white_adipose0.46523982
90MP0002128_abnormal_blood_circulation0.45956997
91MP0000470_abnormal_stomach_morphology0.45424971
92MP0001784_abnormal_fluid_regulation0.44628022
93MP0000749_muscle_degeneration0.43828041
94MP0002111_abnormal_tail_morphology0.40200661
95MP0002249_abnormal_larynx_morphology0.38035789
96MP0010352_gastrointestinal_tract_polyps0.35318774
97MP0005075_abnormal_melanosome_morpholog0.35138276
98MP0009840_abnormal_foam_cell0.34089264
99MP0004272_abnormal_basement_membrane0.33005594
100MP0000678_abnormal_parathyroid_gland0.32716028
101MP0002177_abnormal_outer_ear0.32599114
102MP0003385_abnormal_body_wall0.30571551
103MP0000537_abnormal_urethra_morphology0.29767777
104MP0003329_amyloid_beta_deposits0.27156112
105MP0003763_abnormal_thymus_physiology0.25207949
106MP0000465_gastrointestinal_hemorrhage0.24831601
107MP0003950_abnormal_plasma_membrane0.24356525
108MP0002697_abnormal_eye_size0.23337167
109MP0005248_abnormal_Harderian_gland0.21096328
110MP0006054_spinal_hemorrhage0.21029315
111MP0004019_abnormal_vitamin_homeostasis0.19527659
112MP0003300_gastrointestinal_ulcer0.18710299
113MP0000432_abnormal_head_morphology0.17542107
114MP0005666_abnormal_adipose_tissue0.16067200
115MP0003448_altered_tumor_morphology0.15445661
116MP0001879_abnormal_lymphatic_vessel0.15183221
117MP0003935_abnormal_craniofacial_develop0.14877906
118MP0004742_abnormal_vestibular_system0.14835342
119MP0000604_amyloidosis0.14832502
120MP0003638_abnormal_response/metabolism_0.14293453
121MP0005375_adipose_tissue_phenotype0.14066650
122MP0004858_abnormal_nervous_system0.14029408
123MP0001958_emphysema0.13141229
124MP0003011_delayed_dark_adaptation0.12855093
125MP0002006_tumorigenesis0.11654449
126MP0002166_altered_tumor_susceptibility0.11097897
127MP0005076_abnormal_cell_differentiation0.10735406
128MP0003075_altered_response_to0.10439539
129MP0003045_fibrosis0.10271278
130MP0002233_abnormal_nose_morphology0.10170304
131MP0000516_abnormal_urinary_system0.09490371
132MP0005367_renal/urinary_system_phenotyp0.09490371
133MP0000751_myopathy0.08930103
134MP0005193_abnormal_anterior_eye0.08552957
135MP0000013_abnormal_adipose_tissue0.07754389
136MP0009384_cardiac_valve_regurgitation0.07497093
137MP0000733_abnormal_muscle_development0.07483913
138MP0000462_abnormal_digestive_system0.07404814
139MP0006138_congestive_heart_failure0.06709985
140MP0008569_lethality_at_weaning0.06639098

Predicted human phenotypes

RankGene SetZ-score
1Pili torti (HP:0003777)8.78982894
2Nail dystrophy (HP:0008404)7.55822482
3Premature rupture of membranes (HP:0001788)6.37455832
4Abnormality of nail color (HP:0100643)6.09132077
5Protrusio acetabuli (HP:0003179)5.88628246
6Abnormal hair laboratory examination (HP:0003328)5.55832942
7Fragile nails (HP:0001808)5.44875670
8Fine hair (HP:0002213)5.42856786
9Alopecia of scalp (HP:0002293)4.89242310
10Palmoplantar hyperkeratosis (HP:0000972)4.74357879
11Onycholysis (HP:0001806)4.61853226
12Fragile skin (HP:0001030)4.61475307
13Palmar hyperkeratosis (HP:0010765)4.46263980
14Thick nail (HP:0001805)4.43284271
15Increased IgE level (HP:0003212)4.42709301
16Plantar hyperkeratosis (HP:0007556)4.31674181
17Follicular hyperkeratosis (HP:0007502)4.22072214
18Ankle contracture (HP:0006466)4.20916873
19Right ventricular cardiomyopathy (HP:0011663)4.10277241
20Aortic aneurysm (HP:0004942)3.64192159
21Aortic dissection (HP:0002647)3.43852434
22Sparse eyelashes (HP:0000653)3.43761820
23Erythema (HP:0010783)3.41681559
24Bladder diverticulum (HP:0000015)3.40138371
25Neonatal short-limb short stature (HP:0008921)3.36394739
26Vascular tortuosity (HP:0004948)3.32144887
27Oral leukoplakia (HP:0002745)3.29644645
28Cervical subluxation (HP:0003308)3.22263987
29Soft skin (HP:0000977)3.20860645
30Milia (HP:0001056)3.15777406
31Abnormality of dentin (HP:0010299)3.05181405
32Abnormality of the frontal sinuses (HP:0002687)3.03765865
33Amelogenesis imperfecta (HP:0000705)3.01647460
34Spinal rigidity (HP:0003306)3.01239348
35Erythroderma (HP:0001019)2.90900753
36Parakeratosis (HP:0001036)2.88878201
37Arterial tortuosity (HP:0005116)2.81203497
38Vertebral compression fractures (HP:0002953)2.80490038
39Broad metatarsal (HP:0001783)2.79573391
40Wormian bones (HP:0002645)2.72044157
41Slender build (HP:0001533)2.69368346
42Curly hair (HP:0002212)2.68569870
43Cardiovascular calcification (HP:0011915)2.66124518
44Congenital ichthyosiform erythroderma (HP:0007431)2.66003151
45Ridged nail (HP:0001807)2.62368864
46Hypoplasia of dental enamel (HP:0006297)2.59608906
47Genu recurvatum (HP:0002816)2.57578855
48Intention tremor (HP:0002080)2.57216944
49Congenital, generalized hypertrichosis (HP:0004540)2.51395954
50Ankyloglossia (HP:0010296)2.45128012
51Neck muscle weakness (HP:0000467)2.40539342
52Shallow orbits (HP:0000586)2.39348976
53Abnormal blistering of the skin (HP:0008066)2.38683762
54Dilatation of the ascending aorta (HP:0005111)2.38113902
55Aplasia cutis congenita (HP:0001057)2.37108254
56Torticollis (HP:0000473)2.36121457
57Dry hair (HP:0011359)2.36111630
58Bowel diverticulosis (HP:0005222)2.36090264
59Natal tooth (HP:0000695)2.35094434
60Poikiloderma (HP:0001029)2.26839954
61Blue sclerae (HP:0000592)2.26280950
62Advanced eruption of teeth (HP:0006288)2.25146603
63Mildly elevated creatine phosphokinase (HP:0008180)2.22698501
64Abnormality of oral frenula (HP:0000190)2.19163557
65Vascular calcification (HP:0004934)2.17888912
66Elbow flexion contracture (HP:0002987)2.17782333
67Peritonitis (HP:0002586)2.17586630
68Xerostomia (HP:0000217)2.16989592
69Trismus (HP:0000211)2.16698713
70Corneal erosion (HP:0200020)2.09004032
71Syringomyelia (HP:0003396)2.08743427
72Spinal cord lesions (HP:0100561)2.08743427
73Hypohidrosis (HP:0000966)2.07327753
74Short nail (HP:0001799)2.05833149
75Biconcave vertebral bodies (HP:0004586)2.04952175
76Aortic regurgitation (HP:0001659)2.02706341
77Palmoplantar keratoderma (HP:0000982)2.01125913
78Hypotrichosis (HP:0001006)15.1480887
79Slow-growing hair (HP:0002217)11.5170635
80Abnormality of hair growth rate (HP:0011363)11.5170635
81Woolly hair (HP:0002224)10.9224956
82Brittle hair (HP:0002299)10.8164215
83Craniofacial dystonia (HP:0012179)1.99848270
84Joint laxity (HP:0001388)1.96369571
85Ventricular tachycardia (HP:0004756)1.94955159
86Mitral regurgitation (HP:0001653)1.94686424
87Abnormality of the acetabulum (HP:0003170)1.92949318
88Coronal craniosynostosis (HP:0004440)1.92387596
89Increased variability in muscle fiber diameter (HP:0003557)1.92145687
90Osteolytic defects of the phalanges of the hand (HP:0009771)1.91499060
91Osteolytic defects of the hand bones (HP:0009699)1.91499060
92Spondylolisthesis (HP:0003302)1.88751709
93Pruritus (HP:0000989)1.87889474
94Wrist flexion contracture (HP:0001239)1.85236768
95Hypodontia (HP:0000668)1.85227176
96Difficulty walking (HP:0002355)1.84736330
97Abnormality of the pupil (HP:0000615)1.84730182
98Focal dystonia (HP:0004373)1.82764839
99Abnormal delivery (HP:0001787)1.82550684
100Distal upper limb amyotrophy (HP:0007149)1.82265152
101Upper limb amyotrophy (HP:0009129)1.82265152
102Cheilitis (HP:0100825)1.81164092
103Reduced subcutaneous adipose tissue (HP:0003758)1.80702897
104Hyperextensible skin (HP:0000974)1.78569042
105Overgrowth (HP:0001548)1.76641027
106Concave nail (HP:0001598)1.76141522
107Ventricular fibrillation (HP:0001663)1.74885518
108Abnormality of the parietal bone (HP:0002696)1.72740426
109Hyperhidrosis (HP:0000975)1.72154553
110Aortic valve stenosis (HP:0001650)1.71387072
111Periodontitis (HP:0000704)1.71205089
112Hypoventilation (HP:0002791)1.71053809
113Abnormality of the dental root (HP:0006486)1.70293454
114Taurodontia (HP:0000679)1.70293454
115Abnormality of permanent molar morphology (HP:0011071)1.70293454
116Abnormality of dental color (HP:0011073)1.70068058
117Wide anterior fontanel (HP:0000260)1.69801199
118Hoarse voice (HP:0001609)1.69685018
119Mild short stature (HP:0003502)1.69469599
120Abnormality of molar (HP:0011077)1.68684559
121Abnormality of molar morphology (HP:0011070)1.68684559
122Mitral valve prolapse (HP:0001634)1.68448721
123Tibial bowing (HP:0002982)1.65562293
124Abnormality of skeletal muscle fiber size (HP:0012084)1.64921899
125Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.63959510
126Widely patent fontanelles and sutures (HP:0004492)1.63919472
127Conjunctival hamartoma (HP:0100780)1.63212840
128Ulnar bowing (HP:0003031)1.62979802
129Fatigable weakness (HP:0003473)1.61181491
130Abnormality of the neuromuscular junction (HP:0003398)1.61181491
131Absent eyelashes (HP:0000561)1.58804574
132Hyporeflexia of lower limbs (HP:0002600)1.58164503
133Recurrent corneal erosions (HP:0000495)1.56555787
134Blepharitis (HP:0000498)1.53875743
135Abnormality of the dental pulp (HP:0006479)1.48639305
136Unilateral renal agenesis (HP:0000122)1.47426964
137Abnormality of the aortic arch (HP:0012303)1.47378380
138Heterogeneous (HP:0001425)1.46931106
139Sudden death (HP:0001699)1.45576108
140Acanthosis nigricans (HP:0000956)1.43532006
141Abnormality of placental membranes (HP:0011409)1.42181646
142Amniotic constriction ring (HP:0009775)1.42181646
143Achilles tendon contracture (HP:0001771)1.36427459
144Lip pit (HP:0100267)1.36384218
145Carious teeth (HP:0000670)1.36222540
146Gangrene (HP:0100758)1.36013545
147Keratoconjunctivitis sicca (HP:0001097)1.35531125
148Ectropion (HP:0000656)1.35498702
149Distal lower limb muscle weakness (HP:0009053)1.32789807
150Anonychia (HP:0001798)1.30814385
151Hypergammaglobulinemia (HP:0010702)1.29654844
152Craniofacial hyperostosis (HP:0004493)1.28484475
153Abnormality of the Achilles tendon (HP:0005109)1.28378536
154Autoamputation (HP:0001218)1.26692269
155Atrophic scars (HP:0001075)1.25881250
156Variable expressivity (HP:0003828)1.25840714
157Abnormality of the fingernails (HP:0001231)1.23987619
158Neonatal onset (HP:0003623)1.23124524
159Lack of skin elasticity (HP:0100679)1.20756401
160Increased connective tissue (HP:0009025)1.20085838
161Round ear (HP:0100830)1.20070278
162Keratoconjunctivitis (HP:0001096)1.18980669
163Type 1 muscle fiber predominance (HP:0003803)1.16472431
164Laryngomalacia (HP:0001601)1.15376344
165Selective tooth agenesis (HP:0001592)1.15338312
166Sparse scalp hair (HP:0002209)1.14356681
167Widely spaced teeth (HP:0000687)1.11678407
168Bronchomalacia (HP:0002780)1.09741369

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK4.58621399
2EPHA24.35999984
3MAPKAPK34.13337904
4FER4.06925959
5ERN13.89573841
6MAP3K63.72581925
7EPHB23.07076338
8TAOK13.04610147
9MAP3K32.77672066
10TRIB32.73919293
11NEK92.56991488
12LATS12.39534816
13MAP3K22.38556871
14MAP3K112.07281853
15RPS6KB22.00048308
16AKT31.91712794
17EEF2K1.87162173
18TTN1.81854367
19MOS1.76562244
20MAP2K61.75449008
21PIK3CG1.71263727
22EPHB11.67320099
23LATS21.62562286
24SCYL21.60686989
25NTRK11.54671393
26PRKD21.54319509
27PDGFRB1.52842337
28ABL21.40798460
29PTK2B1.35453897
30NME11.34503375
31FGFR41.31084201
32FGFR21.30480823
33BCR1.29741695
34MAP3K11.29146485
35RIPK11.25118128
36FGFR11.23388208
37LMTK21.22913773
38PKN21.22494247
39BMX1.22076314
40KSR21.21394151
41MST1R1.20810423
42MAP2K31.19402287
43BLK1.17501659
44CDK61.11579567
45TAOK21.10455668
46PDGFRA1.09445160
47MAPKAPK21.07992637
48FLT31.05852545
49MAP3K121.05773310
50CDC42BPA1.04801694
51FGFR31.04205524
52LRRK21.02777394
53PTK61.01302814
54STK241.00625596
55ARAF0.98752776
56MAP3K70.97688033
57STK30.97666372
58MAP3K90.95442530
59PBK0.91716205
60SIK10.90137420
61MAP2K40.85580483
62RPS6KA20.84934098
63RPS6KA40.82839809
64PRPF4B0.81005667
65PTK20.80401893
66STK380.79908945
67DAPK30.79432840
68MAP2K10.78991685
69MAPK70.78825240
70ROCK10.78161365
71IRAK30.73471746
72PIM20.72339111
73PAK40.72149267
74DDR20.70073067
75MET0.69957415
76STK38L0.69712049
77PAK30.69585805
78PRKD10.69308646
79WNK10.68406937
80TESK10.68013212
81MTOR0.67230293
82DYRK1B0.66190325
83CDK190.65151613
84MAP3K100.60807143
85PAK10.60308420
86SGK30.59351025
87GRK70.59288175
88DMPK0.58543762
89NTRK20.57989302
90PRKCH0.57788962
91PRKG20.56813158
92TYRO30.55902181
93MAP3K130.55637171
94ERBB40.55348675
95TRPM70.55313704
96PRKCI0.55293088
97MAP3K140.54902557
98MAP3K50.53907969
99EPHA30.53217764
100RET0.52308901
101JAK10.51565939
102KIT0.51239421
103PAK60.50771996
104TGFBR10.50433808
105ADRBK10.49732268
106PAK20.48954480
107ALK0.48379948
108ABL10.48175456
109PRKD30.47095182
110TYK20.46617486
111ERBB20.46590569
112OBSCN0.45053479
113MAPK120.44824702
114RPS6KA10.44707613
115NEK10.44537429
116JAK30.43896094
117PRKCE0.42445853
118BRAF0.40769065
119GSK3A0.40019147
120CSNK1E0.39430573
121MAP2K20.39152402
122RPS6KL10.37685742
123RPS6KC10.37685742
124MST40.36720408
125JAK20.36085131
126GRK60.33867183
127ILK0.32709761
128CLK10.30536182
129CAMK2G0.30192752
130MAP3K80.29927513
131FYN0.29918934
132TGFBR20.29258478
133ERBB30.28440600
134LIMK10.28346544
135ICK0.28147848
136RAF10.28005364
137INSR0.26066272
138SRC0.25371640
139HCK0.24948777
140CSNK1A10.24207736
141PHKG20.23362094
142PHKG10.23362094
143ROCK20.22737464
144STK110.22664652
145PRKCD0.22445097
146RPS6KA60.21521087
147PRKACG0.21064730
148CSNK1D0.20814946

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005925.02173586
2Linoleic acid metabolism_Homo sapiens_hsa005914.98176940
3Fat digestion and absorption_Homo sapiens_hsa049753.28979167
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.89779063
5Small cell lung cancer_Homo sapiens_hsa052222.88382844
6Fatty acid elongation_Homo sapiens_hsa000622.69077646
7Ether lipid metabolism_Homo sapiens_hsa005652.63254983
8Basal cell carcinoma_Homo sapiens_hsa052172.13215121
9Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.09872966
10Arachidonic acid metabolism_Homo sapiens_hsa005901.95076354
11Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.91613022
12Regulation of actin cytoskeleton_Homo sapiens_hsa048101.90800641
13Phenylalanine metabolism_Homo sapiens_hsa003601.84555347
14Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.80250377
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.75321812
16Dilated cardiomyopathy_Homo sapiens_hsa054141.73750980
17VEGF signaling pathway_Homo sapiens_hsa043701.70535096
18PI3K-Akt signaling pathway_Homo sapiens_hsa041511.68422879
19Melanogenesis_Homo sapiens_hsa049161.54939735
20Axon guidance_Homo sapiens_hsa043601.50936067
21Histidine metabolism_Homo sapiens_hsa003401.38427061
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.35889339
23Caffeine metabolism_Homo sapiens_hsa002321.34808577
24Glioma_Homo sapiens_hsa052141.32442174
25Hedgehog signaling pathway_Homo sapiens_hsa043401.32025836
26Vascular smooth muscle contraction_Homo sapiens_hsa042701.32013591
27Bladder cancer_Homo sapiens_hsa052191.31957733
28Shigellosis_Homo sapiens_hsa051311.31854176
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.30394659
30Pathways in cancer_Homo sapiens_hsa052001.27356077
31Thyroid cancer_Homo sapiens_hsa052161.27300534
32Proteoglycans in cancer_Homo sapiens_hsa052051.25781787
33GnRH signaling pathway_Homo sapiens_hsa049121.22732985
34Sphingolipid metabolism_Homo sapiens_hsa006001.19375151
35Hippo signaling pathway_Homo sapiens_hsa043901.19176438
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.15502177
37Acute myeloid leukemia_Homo sapiens_hsa052211.15302738
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15223927
39Pancreatic secretion_Homo sapiens_hsa049721.13012742
40Melanoma_Homo sapiens_hsa052181.11766807
41Tight junction_Homo sapiens_hsa045301.07590952
42Endocytosis_Homo sapiens_hsa041441.06321075
43Sulfur metabolism_Homo sapiens_hsa009201.03965960
44Dorso-ventral axis formation_Homo sapiens_hsa043201.03618002
45Malaria_Homo sapiens_hsa051441.03340046
46Mineral absorption_Homo sapiens_hsa049781.02992595
47PPAR signaling pathway_Homo sapiens_hsa033201.02973840
48Nitrogen metabolism_Homo sapiens_hsa009101.01716286
49ECM-receptor interaction_Homo sapiens_hsa045121.01145299
50Long-term potentiation_Homo sapiens_hsa047201.00907580
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.00777918
52Glycerophospholipid metabolism_Homo sapiens_hsa005640.96613897
53Steroid biosynthesis_Homo sapiens_hsa001000.94203815
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.94051465
55Vibrio cholerae infection_Homo sapiens_hsa051100.92702473
56Tyrosine metabolism_Homo sapiens_hsa003500.91281696
57Adherens junction_Homo sapiens_hsa045200.90848532
58Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87921183
59Pertussis_Homo sapiens_hsa051330.85905011
60Non-small cell lung cancer_Homo sapiens_hsa052230.85422189
61Endometrial cancer_Homo sapiens_hsa052130.83772875
62Ras signaling pathway_Homo sapiens_hsa040140.82695114
63Renin-angiotensin system_Homo sapiens_hsa046140.82508055
64Estrogen signaling pathway_Homo sapiens_hsa049150.82237663
65beta-Alanine metabolism_Homo sapiens_hsa004100.81035474
66Long-term depression_Homo sapiens_hsa047300.80885274
67Amoebiasis_Homo sapiens_hsa051460.77378072
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.76240455
69Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.75050041
70Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74675880
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74497906
72TNF signaling pathway_Homo sapiens_hsa046680.73959781
73Other glycan degradation_Homo sapiens_hsa005110.73828784
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73319123
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72900111
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.72681647
77Pancreatic cancer_Homo sapiens_hsa052120.72627743
78Staphylococcus aureus infection_Homo sapiens_hsa051500.72535035
79Wnt signaling pathway_Homo sapiens_hsa043100.72504807
80Lysosome_Homo sapiens_hsa041420.71866986
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.69309188
82Prostate cancer_Homo sapiens_hsa052150.67843772
83Gastric acid secretion_Homo sapiens_hsa049710.67186670
84Phagosome_Homo sapiens_hsa041450.66956719
85Renin secretion_Homo sapiens_hsa049240.64693584
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63728095
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.62976667
88Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.62532820
89Phototransduction_Homo sapiens_hsa047440.60429302
90MicroRNAs in cancer_Homo sapiens_hsa052060.59764223
91Fatty acid metabolism_Homo sapiens_hsa012120.59247458
92Protein digestion and absorption_Homo sapiens_hsa049740.57576085
93Insulin resistance_Homo sapiens_hsa049310.57472763
94MAPK signaling pathway_Homo sapiens_hsa040100.56136606
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55976166
96Hepatitis C_Homo sapiens_hsa051600.55965488
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.55316999
98Gap junction_Homo sapiens_hsa045400.54522044
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54448551
100Rap1 signaling pathway_Homo sapiens_hsa040150.53607750
101Salmonella infection_Homo sapiens_hsa051320.52732812
102Inositol phosphate metabolism_Homo sapiens_hsa005620.52702212
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52334844
104Salivary secretion_Homo sapiens_hsa049700.52234180
105Focal adhesion_Homo sapiens_hsa045100.50881601
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.49676022
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.49204881
108Platelet activation_Homo sapiens_hsa046110.48473714
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47596494
110Renal cell carcinoma_Homo sapiens_hsa052110.47488980
111Oxytocin signaling pathway_Homo sapiens_hsa049210.46959762
112Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46626115
113Butanoate metabolism_Homo sapiens_hsa006500.46560728
114Fatty acid degradation_Homo sapiens_hsa000710.46445299
115ErbB signaling pathway_Homo sapiens_hsa040120.44710367
116Vitamin B6 metabolism_Homo sapiens_hsa007500.44655449
117Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44545099
118Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42423008
119Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.41746189
120Chemical carcinogenesis_Homo sapiens_hsa052040.41663277
121Apoptosis_Homo sapiens_hsa042100.41607527
122Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41282296
123Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40727699
124mTOR signaling pathway_Homo sapiens_hsa041500.40412561
125Jak-STAT signaling pathway_Homo sapiens_hsa046300.39629416
126Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39592226
127Prion diseases_Homo sapiens_hsa050200.39096923
128TGF-beta signaling pathway_Homo sapiens_hsa043500.38930659
129Chronic myeloid leukemia_Homo sapiens_hsa052200.37820995
130Tuberculosis_Homo sapiens_hsa051520.37762627
131Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37745128
132Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37426961
133Toxoplasmosis_Homo sapiens_hsa051450.37102372
134Olfactory transduction_Homo sapiens_hsa047400.36868146
135AMPK signaling pathway_Homo sapiens_hsa041520.36143746
136Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35856543
137Prolactin signaling pathway_Homo sapiens_hsa049170.35464481
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35157367
139N-Glycan biosynthesis_Homo sapiens_hsa005100.35033371
140Arginine biosynthesis_Homo sapiens_hsa002200.34176774
141Insulin signaling pathway_Homo sapiens_hsa049100.33079011
142p53 signaling pathway_Homo sapiens_hsa041150.33012724
143Notch signaling pathway_Homo sapiens_hsa043300.32896268
144Primary bile acid biosynthesis_Homo sapiens_hsa001200.31546765
145Galactose metabolism_Homo sapiens_hsa000520.31420809
146Hepatitis B_Homo sapiens_hsa051610.28934852
147HTLV-I infection_Homo sapiens_hsa051660.28494327
148Selenocompound metabolism_Homo sapiens_hsa004500.27736657

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