KRT33A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the keratin gene family. This gene is one of multiple type I hair keratin genes that are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. As a type I hair keratin, the encoded protein is an acidic protein which heterodimerizes with type II keratins to form hair and nails. There are two isoforms of this protein, encoded by two separate genes, keratin 33A and keratin 33B. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1adhesion of symbiont to host cell (GO:0044650)9.84617504
2virion attachment to host cell (GO:0019062)9.84617504
3fusion of sperm to egg plasma membrane (GO:0007342)9.80657530
4response to pheromone (GO:0019236)9.02646275
5citrulline biosynthetic process (GO:0019240)8.80283055
6chromosome condensation (GO:0030261)8.49992644
7peptide cross-linking (GO:0018149)8.48202190
8hair follicle morphogenesis (GO:0031069)8.31661217
9adhesion of symbiont to host (GO:0044406)8.30231885
10spermatid nucleus differentiation (GO:0007289)8.20157358
11DNA packaging (GO:0006323)8.14880435
12sperm capacitation (GO:0048240)8.13425442
13single strand break repair (GO:0000012)7.63965417
14plasma membrane fusion (GO:0045026)7.42737905
15spermatid development (GO:0007286)7.09082094
16microtubule depolymerization (GO:0007019)7.00746221
17sexual reproduction (GO:0019953)6.76809122
18intermediate filament cytoskeleton organization (GO:0045104)6.70747087
19sperm-egg recognition (GO:0035036)6.54747984
20intermediate filament-based process (GO:0045103)6.49256462
21negative regulation of inclusion body assembly (GO:0090084)6.35207110
22cell wall macromolecule catabolic process (GO:0016998)6.33903931
23cell wall macromolecule metabolic process (GO:0044036)6.33903931
24rRNA methylation (GO:0031167)6.27941975
25epidermis development (GO:0008544)6.25965108
26multicellular organism reproduction (GO:0032504)6.25252747
27reproduction (GO:0000003)6.17334313
28binding of sperm to zona pellucida (GO:0007339)6.09753980
29establishment of skin barrier (GO:0061436)6.07621159
30protein polyglutamylation (GO:0018095)5.94272878
31keratinocyte differentiation (GO:0030216)5.87666050
32calcium ion-dependent exocytosis (GO:0017156)5.83420662
33citrulline metabolic process (GO:0000052)5.81807195
34microtubule polymerization or depolymerization (GO:0031109)5.80745432
35protein targeting to Golgi (GO:0000042)5.66357362
36phosphatidylethanolamine biosynthetic process (GO:0006646)5.53502870
37axonemal dynein complex assembly (GO:0070286)5.47471717
38cellular ketone body metabolic process (GO:0046950)5.44057782
39molting cycle process (GO:0022404)5.41810975
40hair cycle process (GO:0022405)5.41810975
41establishment of protein localization to Golgi (GO:0072600)5.41513108
42regulation of water loss via skin (GO:0033561)5.38570557
43spermatogenesis (GO:0007283)5.38401533
44male gamete generation (GO:0048232)5.36470483
45retrograde transport, vesicle recycling within Golgi (GO:0000301)5.36409665
46cell-cell recognition (GO:0009988)5.35602075
47rRNA modification (GO:0000154)5.19746375
48phosphatidylethanolamine metabolic process (GO:0046337)5.13446521
49bundle of His cell to Purkinje myocyte communication (GO:0086069)5.08533136
50microtubule severing (GO:0051013)4.98524795
51antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.98217739
52gamete generation (GO:0007276)4.91495486
53hemidesmosome assembly (GO:0031581)4.89402468
54peptidyl-arginine modification (GO:0018195)4.86990607
55skin morphogenesis (GO:0043589)4.82068712
56ketone body metabolic process (GO:1902224)4.80504092
57regulation of inclusion body assembly (GO:0090083)4.59289372
58epidermal cell differentiation (GO:0009913)4.58794984
59centriole replication (GO:0007099)4.48545425
60regulation of Rab GTPase activity (GO:0032313)4.45112964
61positive regulation of Rab GTPase activity (GO:0032851)4.45112964
62chromatin silencing (GO:0006342)4.36435846
63single fertilization (GO:0007338)4.32353859
64regulation of cilium movement (GO:0003352)4.32323812
65motile cilium assembly (GO:0044458)4.31581069
66cilium or flagellum-dependent cell motility (GO:0001539)4.26907872
67protein localization to Golgi apparatus (GO:0034067)4.05845653
68germ cell development (GO:0007281)4.05234150
69molting cycle (GO:0042303)34.5509903
70hair cycle (GO:0042633)34.5509903
71multicellular organismal reproductive process (GO:0048609)3.95791784
72RNA destabilization (GO:0050779)3.92661071
73centriole assembly (GO:0098534)3.91256034
74tooth mineralization (GO:0034505)3.91063091
75keratinocyte development (GO:0003334)3.86402634
76cellular process involved in reproduction in multicellular organism (GO:0022412)3.85456956
77glycerol ether metabolic process (GO:0006662)3.81500466
78nucleus organization (GO:0006997)3.78759932
79regulation of transcription involved in cell fate commitment (GO:0060850)3.77002547
80multicellular organismal water homeostasis (GO:0050891)3.61761197
81fertilization (GO:0009566)3.54909185
82regulation of centriole replication (GO:0046599)3.54794014
83ether metabolic process (GO:0018904)3.51546412
84epithelial cilium movement (GO:0003351)3.42514359
85negative regulation of keratinocyte proliferation (GO:0010839)3.38063217
86seminiferous tubule development (GO:0072520)3.36953646
87coenzyme catabolic process (GO:0009109)3.36392467
88regulation of keratinocyte differentiation (GO:0045616)3.35374341
89phosphatidylinositol acyl-chain remodeling (GO:0036149)3.33604159
90positive regulation of hair follicle development (GO:0051798)3.27862058
91positive regulation of hair cycle (GO:0042635)3.27862058
92hair follicle development (GO:0001942)3.27450539
93negative regulation of Rho protein signal transduction (GO:0035024)3.25912032
94glomerular visceral epithelial cell development (GO:0072015)3.23666494
95negative regulation of establishment of protein localization to plasma membrane (GO:0090005)3.16352725
96cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.12136381
97glomerular epithelial cell development (GO:0072310)3.11407191
98cilium movement (GO:0003341)3.08092566
99multicellular organismal movement (GO:0050879)3.06618463
100musculoskeletal movement (GO:0050881)3.06618463
101regulation of hair follicle development (GO:0051797)3.06454418
102phosphatidylserine acyl-chain remodeling (GO:0036150)3.04953114
103bone trabecula formation (GO:0060346)3.02269128
104epithelium development (GO:0060429)2.96733847
105water homeostasis (GO:0030104)2.96319296
106negative regulation of gene expression, epigenetic (GO:0045814)2.95599464
107protein-DNA complex disassembly (GO:0032986)2.90267343
108nucleosome disassembly (GO:0006337)2.90267343
109organic cation transport (GO:0015695)2.89404538
110gap junction assembly (GO:0016264)2.82267471
111positive regulation of meiotic cell cycle (GO:0051446)2.80418932
112phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.79586153
113peptidyl-threonine dephosphorylation (GO:0035970)2.77670619
114regulation of interleukin-13 production (GO:0032656)2.77651356
115histone H3-K9 demethylation (GO:0033169)2.76985562
116regulation of hair cycle (GO:0042634)2.75396897
117ectoderm development (GO:0007398)2.73848738
118positive regulation of epidermis development (GO:0045684)2.73784423
119cell differentiation involved in metanephros development (GO:0072202)2.73568904
120response to acidic pH (GO:0010447)2.71716709
121regulation of microtubule-based movement (GO:0060632)2.71227867
122membrane protein intracellular domain proteolysis (GO:0031293)2.70118462
123homeostasis of number of cells within a tissue (GO:0048873)2.68518880
124cerebral cortex neuron differentiation (GO:0021895)2.68192296
125fatty acid elongation (GO:0030497)2.67194238
126multicellular organismal development (GO:0007275)2.65199254
127retinol metabolic process (GO:0042572)2.62897798
128negative regulation of protein localization to plasma membrane (GO:1903077)2.61692189
129mesenchymal cell differentiation involved in kidney development (GO:0072161)2.60075575
130atrioventricular valve morphogenesis (GO:0003181)2.59782419
131regulation of epidermal cell differentiation (GO:0045604)2.59736323
132epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.51139374
133regulation of epidermis development (GO:0045682)2.50173231
134ventricular cardiac muscle cell action potential (GO:0086005)2.34298609
135phosphatidylserine metabolic process (GO:0006658)2.30647728
136negative regulation of cell fate specification (GO:0009996)2.30203729
137wound healing, spreading of epidermal cells (GO:0035313)2.29498303
138cell surface receptor signaling pathway involved in heart development (GO:0061311)2.28041867
139regulation of mesenchymal cell apoptotic process (GO:2001053)2.23941424
140positive regulation of epidermal cell differentiation (GO:0045606)2.23824612
141phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.23500001
142cranial suture morphogenesis (GO:0060363)2.22688334
143positive regulation of monocyte chemotaxis (GO:0090026)2.19793158
144skin development (GO:0043588)2.18780352
145lymph vessel development (GO:0001945)2.16529653
146regulation of ruffle assembly (GO:1900027)2.03547938
147negative regulation of epidermis development (GO:0045683)2.03454803
148aging (GO:0007568)2.03146907
149regulation of cardioblast differentiation (GO:0051890)2.02431111
150epithelial cell-cell adhesion (GO:0090136)2.01781432
151myotube differentiation (GO:0014902)2.00072894
152intermediate filament organization (GO:0045109)12.1413313
153keratinization (GO:0031424)11.9133945
154acrosome reaction (GO:0007340)10.9113902
155sperm motility (GO:0030317)10.5293205
156desmosome organization (GO:0002934)10.2368990
157outflow tract septum morphogenesis (GO:0003148)1.99784765
158phosphatidylcholine acyl-chain remodeling (GO:0036151)1.97151665
159planar cell polarity pathway involved in neural tube closure (GO:0090179)1.96818186
160cytoskeletal anchoring at plasma membrane (GO:0007016)1.96364504
161regulation of heart rate by cardiac conduction (GO:0086091)1.95730421
162regulation of keratinocyte proliferation (GO:0010837)1.91048102
163regulation of Wnt signaling pathway involved in heart development (GO:0003307)1.88311755
164ephrin receptor signaling pathway (GO:0048013)1.87188234
165cell communication involved in cardiac conduction (GO:0086065)1.85441537
166non-canonical Wnt signaling pathway (GO:0035567)1.83696259
167regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)1.81248459
168cell-substrate junction assembly (GO:0007044)1.80022246
169keratinocyte proliferation (GO:0043616)1.73076452
170regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901211.71933533
171alditol phosphate metabolic process (GO:0052646)1.69765310
172very long-chain fatty acid metabolic process (GO:0000038)1.67578877
173coronary vasculature morphogenesis (GO:0060977)1.65541389
174primary alcohol catabolic process (GO:0034310)1.64743745
175establishment of planar polarity (GO:0001736)1.63991515
176establishment of tissue polarity (GO:0007164)1.63991515
177negative regulation of epidermal cell differentiation (GO:0045605)1.63147577
178regulation of secondary heart field cardioblast proliferation (GO:0003266)1.61261840
179regulation of cardioblast proliferation (GO:0003264)1.61261840
180G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071991.60888860
181craniofacial suture morphogenesis (GO:0097094)1.60795576
182wound healing, spreading of cells (GO:0044319)1.60588462
183cardiac right ventricle morphogenesis (GO:0003215)1.58835273
184regulation of monocyte chemotaxis (GO:0090025)1.57506304

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.46516012
2CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.99643151
3* P63_26484246_Chip-Seq_KERATINOCYTES_Human3.48654313
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.25646807
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.79199699
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.78984174
7POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.33323446
8TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.33323446
9* CTCF_20526341_ChIP-Seq_ESCs_Human2.21087888
10BMI1_19503595_ChIP-Seq_MEFsC_Mouse2.13067458
11IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.04519233
12CBP_20019798_ChIP-Seq_JUKART_Human2.04519233
13TP63_17297297_ChIP-ChIP_HaCaT_Human12.7406082
14* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.98301185
15ERA_21632823_ChIP-Seq_H3396_Human1.90713419
16PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.86726907
17E2F1_20622854_ChIP-Seq_HELA_Human1.85954364
18EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.84780757
19TAF2_19829295_ChIP-Seq_ESCs_Human1.84379687
20VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.77452627
21SOX9_24532713_ChIP-Seq_HFSC_Mouse1.74420418
22CSB_26484114_Chip-Seq_FIBROBLAST_Human1.74162181
23EGR1_19032775_ChIP-ChIP_M12_Human1.73716231
24NANOG_20526341_ChIP-Seq_ESCs_Human1.72200801
25ERG_20517297_ChIP-Seq_VCAP_Human1.68113995
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64622973
27CTCF_27219007_Chip-Seq_Bcells_Human1.61854661
28P53_21459846_ChIP-Seq_SAOS-2_Human1.61687693
29RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.61045884
30* P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.60784168
31* EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.57612718
32FOXO3_23340844_ChIP-Seq_DLD1_Human1.57429482
33RACK7_27058665_Chip-Seq_MCF-7_Human1.52936906
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52169834
35MYC_19829295_ChIP-Seq_ESCs_Human1.50386881
36LXR_22292898_ChIP-Seq_THP-1_Human1.48424409
37DROSHA_22980978_ChIP-Seq_HELA_Human1.48348344
38DNAJC2_21179169_ChIP-ChIP_NT2_Human1.47797208
39MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.47317768
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45281050
41* TP63_22573176_ChIP-Seq_HFKS_Human1.44383028
42OCT4_20526341_ChIP-Seq_ESCs_Human1.43994526
43EZH2_22144423_ChIP-Seq_EOC_Human1.43453992
44ESR1_21235772_ChIP-Seq_MCF-7_Human1.42029891
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41036526
46CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.39885450
47AUTS2_25519132_ChIP-Seq_293T-REX_Human1.39657914
48WDR5_24793694_ChIP-Seq_LNCAP_Human1.38972343
49HNFA_21074721_ChIP-Seq_CACO-2_Human1.38580639
50ATF3_27146783_Chip-Seq_COLON_Human1.37781792
51ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.37769510
52UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.37694287
53* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.37227105
54* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.37227105
55FUS_26573619_Chip-Seq_HEK293_Human1.37181681
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.37131704
57RARG_19884340_ChIP-ChIP_MEFs_Mouse1.36972610
58P300_27268052_Chip-Seq_Bcells_Human1.36437734
59* BCL6_27268052_Chip-Seq_Bcells_Human1.36227312
60FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.34344476
61RBPJ_21746931_ChIP-Seq_IB4_Human1.32994329
62SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.32293517
63SMAD3_21741376_ChIP-Seq_ESCs_Human1.31116831
64* TP53_20018659_ChIP-ChIP_R1E_Mouse1.30506101
65SMAD4_21741376_ChIP-Seq_EPCs_Human1.29532002
66CBX2_22325352_ChIP-Seq_293T-Rex_Human1.28677895
67ESR2_21235772_ChIP-Seq_MCF-7_Human1.28053451
68GATA3_21878914_ChIP-Seq_MCF-7_Human1.27907982
69* BCOR_27268052_Chip-Seq_Bcells_Human1.27846358
70AHR_22903824_ChIP-Seq_MCF-7_Human1.26239245
71KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.23524138
72TDRD3_21172665_ChIP-Seq_MCF-7_Human1.23486589
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21989373
74TRIM28_21343339_ChIP-Seq_HEK293_Human1.20417482
75* YY1_22570637_ChIP-Seq_MALME-3M_Human1.20266500
76SUZ12_27294783_Chip-Seq_ESCs_Mouse1.19527045
77ETV1_20927104_ChIP-Seq_GIST48_Human1.19316939
78KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18241051
79* AR_25329375_ChIP-Seq_VCAP_Human1.17446171
80PHF8_20622853_ChIP-Seq_HELA_Human1.17334385
81SA1_27219007_Chip-Seq_Bcells_Human1.16428584
82TBL1_22424771_ChIP-Seq_293T_Human1.16240014
83ER_23166858_ChIP-Seq_MCF-7_Human1.15524162
84E2F1_17053090_ChIP-ChIP_MCF-7_Human1.15390769
85SMAD3_21741376_ChIP-Seq_EPCs_Human1.15353663
86SOX2_22085726_ChIP-Seq_NPCs_Mouse1.15320411
87ETV2_25802403_ChIP-Seq_MESCs_Mouse1.14461890
88PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.13913854
89NFYB_21822215_ChIP-Seq_K562_Human1.13629458
90ELK4_26923725_Chip-Seq_MESODERM_Mouse1.12998557
91GATA3_24758297_ChIP-Seq_MCF-7_Human1.12911722
92RAC3_21632823_ChIP-Seq_H3396_Human1.11709343
93* PHF8_20622854_ChIP-Seq_HELA_Human1.10632255
94JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09667442
95* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.09502019
96UBF1/2_26484160_Chip-Seq_HMECs_Human1.09211839
97SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08732202
98SMC4_20622854_ChIP-Seq_HELA_Human1.08667783
99PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.08645873
100GATA4_25053715_ChIP-Seq_YYC3_Human1.07701912
101IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07146722
102* P68_20966046_ChIP-Seq_HELA_Human1.07075239
103JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06655898
104P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06274673
105* TP63_23658742_ChIP-Seq_EP156T_Human1.06020961
106ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05414684
107JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05394327
108PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.04774041
109* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04688572
110* FOXA1_25329375_ChIP-Seq_VCAP_Human1.04688572
111TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04680741
112* CEBPB_22108803_ChIP-Seq_LS180_Human1.04452679
113STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04196294
114SA1_27219007_Chip-Seq_ERYTHROID_Human1.04131307
115SOX2_19829295_ChIP-Seq_ESCs_Human1.04113443
116NANOG_19829295_ChIP-Seq_ESCs_Human1.04113443
117SOX2_21211035_ChIP-Seq_LN229_Human1.03805300
118GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.01638846
119EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01173731
120TP53_18474530_ChIP-ChIP_U2OS_Human1.00648676
121SPI1_20517297_ChIP-Seq_HL60_Human1.00491866
122PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00464075
123* ARNT_22903824_ChIP-Seq_MCF-7_Human0.99212753
124KLF5_25053715_ChIP-Seq_YYC3_Human0.98890828
125NFYA_21822215_ChIP-Seq_K562_Human0.96157024
126EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.96137843
127HOXB7_26014856_ChIP-Seq_BT474_Human0.95203554
128RXRA_24833708_ChIP-Seq_LIVER_Mouse0.94946238
129OCT1_27270436_Chip-Seq_PROSTATE_Human0.94549005
130RUNX_20019798_ChIP-Seq_JUKART_Human0.94039769
131FOXH1_21741376_ChIP-Seq_EPCs_Human0.93843410
132GATA6_21074721_ChIP-Seq_CACO-2_Human0.92909256
133NCOR_22424771_ChIP-Seq_293T_Human0.92746743
134KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92737086
135CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92303541
136CBX2_27304074_Chip-Seq_ESCs_Mouse0.92062326
137TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91945089
138SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91543183
139* ELF1_20517297_ChIP-Seq_JURKAT_Human0.91453630
140ERG_21242973_ChIP-ChIP_JURKAT_Human0.90605390
141RXR_22108803_ChIP-Seq_LS180_Human0.89615499
142RING1B_27294783_Chip-Seq_ESCs_Mouse0.89554495
143RUNX1_27514584_Chip-Seq_MCF-7_Human0.89237714
144GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.88031106
145NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.87241087
146ZNF263_19887448_ChIP-Seq_K562_Human0.84580993
147* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.84376200
148SOX2_20726797_ChIP-Seq_SW620_Human0.84331943
149AR_21572438_ChIP-Seq_LNCaP_Human0.82253898
150ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.81585386
151CDX2_19796622_ChIP-Seq_MESCs_Mouse0.81339536
152RNF2_27304074_Chip-Seq_ESCs_Mouse0.81197591
153* FOXH1_21741376_ChIP-Seq_ESCs_Human0.79376415
154EZH2_27294783_Chip-Seq_ESCs_Mouse0.78638197
155ZFP281_18757296_ChIP-ChIP_E14_Mouse0.78027541
156ELK3_25401928_ChIP-Seq_HUVEC_Human0.75472321
157VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.74641932
158KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.74243970
159ZNF217_24962896_ChIP-Seq_MCF-7_Human0.74122561
160AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.73780656
161TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.73396766

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization9.21192859
2MP0000579_abnormal_nail_morphology7.60023540
3MP0002098_abnormal_vibrissa_morphology7.13724834
4MP0000647_abnormal_sebaceous_gland6.39867527
5MP0005377_hearing/vestibular/ear_phenot6.24423953
6MP0003878_abnormal_ear_physiology6.24423953
7MP0002796_impaired_skin_barrier5.97033089
8MP0005275_abnormal_skin_tensile5.22063148
9MP0010234_abnormal_vibrissa_follicle5.08189750
10MP0000383_abnormal_hair_follicle4.63076540
11MP0010678_abnormal_skin_adnexa4.09285554
12MP0000377_abnormal_hair_follicle4.07451301
13MP0005501_abnormal_skin_physiology3.72683761
14MP0003705_abnormal_hypodermis_morpholog3.69094875
15MP0000427_abnormal_hair_cycle3.52599814
16MP0005670_abnormal_white_adipose3.32575896
17MP0003698_abnormal_male_reproductive3.23284306
18MP0002254_reproductive_system_inflammat3.08868405
19MP0001348_abnormal_lacrimal_gland3.03316378
20MP0001929_abnormal_gametogenesis2.70480256
21MP0001216_abnormal_epidermal_layer2.69037462
22MP0004381_abnormal_hair_follicle2.50517534
23MP0010771_integument_phenotype2.33370996
24MP0004947_skin_inflammation2.31772447
25MP0002060_abnormal_skin_morphology2.20447042
26MP0003453_abnormal_keratinocyte_physiol2.16723074
27MP0001243_abnormal_dermal_layer2.16047345
28* MP0000367_abnormal_coat/_hair2.15539506
29MP0002234_abnormal_pharynx_morphology1.96820705
30MP0001485_abnormal_pinna_reflex1.82006836
31MP0005379_endocrine/exocrine_gland_phen1.76156253
32MP0000467_abnormal_esophagus_morphology1.71728198
33MP0003646_muscle_fatigue1.68529260
34MP0002161_abnormal_fertility/fecundity1.66920484
35MP0009931_abnormal_skin_appearance1.51642987
36MP0009053_abnormal_anal_canal1.51346527
37MP0000762_abnormal_tongue_morphology1.48767575
38MP0003566_abnormal_cell_adhesion1.43726609
39MP0003941_abnormal_skin_development1.28370201
40MP0003718_maternal_effect1.27964689
41MP0005409_darkened_coat_color1.25518191
42MP0002132_abnormal_respiratory_system1.14238805
43MP0002210_abnormal_sex_determination1.08413915
44MP0001191_abnormal_skin_condition1.01898243
45MP0001765_abnormal_ion_homeostasis0.98386422
46MP0004885_abnormal_endolymph0.96308728
47MP0001486_abnormal_startle_reflex0.96155552
48MP0005423_abnormal_somatic_nervous0.96119116
49MP0004185_abnormal_adipocyte_glucose0.93972446
50MP0004264_abnormal_extraembryonic_tissu0.89262211
51MP0002095_abnormal_skin_pigmentation0.87408395
52MP0001145_abnormal_male_reproductive0.86029378
53MP0000653_abnormal_sex_gland0.81346344
54MP0008438_abnormal_cutaneous_collagen0.80662844
55MP0005647_abnormal_sex_gland0.77283579
56MP0001851_eye_inflammation0.76214088
57MP0000026_abnormal_inner_ear0.74697980
58MP0001963_abnormal_hearing_physiology0.73083767
59MP0005310_abnormal_salivary_gland0.72640829
60MP0000534_abnormal_ureter_morphology0.72520911
61MP0001346_abnormal_lacrimal_gland0.68198777
62MP0001661_extended_life_span0.67815614
63MP0003315_abnormal_perineum_morphology0.67632750
64MP0001340_abnormal_eyelid_morphology0.66298369
65MP0000566_synostosis0.65722028
66MP0001849_ear_inflammation0.63756608
67MP0002877_abnormal_melanocyte_morpholog0.63574874
68MP0002735_abnormal_chemical_nociception0.62983458
69MP0010030_abnormal_orbit_morphology0.62733059
70MP0001905_abnormal_dopamine_level0.62312994
71MP0002127_abnormal_cardiovascular_syste0.62158498
72MP0002138_abnormal_hepatobiliary_system0.61956956
73MP0004510_myositis0.60871854
74MP0005535_abnormal_body_temperature0.59448094
75MP0005636_abnormal_mineral_homeostasis0.58326022
76MP0003879_abnormal_hair_cell0.57780397
77MP0000627_abnormal_mammary_gland0.56998687
78MP0005083_abnormal_biliary_tract0.55332213
79MP0003191_abnormal_cellular_cholesterol0.54619877
80MP0002229_neurodegeneration0.52685733
81MP0001968_abnormal_touch/_nociception0.51907958
82MP0002282_abnormal_trachea_morphology0.50880553
83MP0005451_abnormal_body_composition0.50268883
84MP0001984_abnormal_olfaction0.49503460
85MP0003755_abnormal_palate_morphology0.49392377
86MP0005551_abnormal_eye_electrophysiolog0.48938684
87MP0005253_abnormal_eye_physiology0.48667318
88MP0005023_abnormal_wound_healing0.47996737
89MP0000015_abnormal_ear_pigmentation0.46601304
90MP0001784_abnormal_fluid_regulation0.46129686
91MP0000681_abnormal_thyroid_gland0.45999482
92MP0001188_hyperpigmentation0.45656640
93MP0002970_abnormal_white_adipose0.45304362
94MP0009115_abnormal_fat_cell0.43309672
95MP0004859_abnormal_synaptic_plasticity0.42067379
96MP0002111_abnormal_tail_morphology0.40964714
97MP0000049_abnormal_middle_ear0.39043801
98MP0002249_abnormal_larynx_morphology0.38227376
99MP0005395_other_phenotype0.36624678
100MP0008569_lethality_at_weaning0.36606098
101MP0010352_gastrointestinal_tract_polyps0.35441012
102MP0005075_abnormal_melanosome_morpholog0.35328326
103MP0009379_abnormal_foot_pigmentation0.34982438
104MP0002653_abnormal_ependyma_morphology0.34611036
105MP0002822_catalepsy0.34186420
106MP0004272_abnormal_basement_membrane0.33496624
107MP0003137_abnormal_impulse_conducting0.33009497
108MP0000537_abnormal_urethra_morphology0.32646508
109MP0003385_abnormal_body_wall0.32520363
110MP0002557_abnormal_social/conspecific_i0.31949227
111MP0002177_abnormal_outer_ear0.31904803
112MP0004085_abnormal_heartbeat0.31386552
113MP0000678_abnormal_parathyroid_gland0.30962488
114MP0002067_abnormal_sensory_capabilities0.29689526
115MP0004782_abnormal_surfactant_physiolog0.29027186
116MP0005174_abnormal_tail_pigmentation0.28915879
117MP0009840_abnormal_foam_cell0.28207851
118MP0000955_abnormal_spinal_cord0.27621103
119MP0002697_abnormal_eye_size0.26022323
120MP0003763_abnormal_thymus_physiology0.24478424
121MP0003950_abnormal_plasma_membrane0.24402804
122MP0005248_abnormal_Harderian_gland0.24384217
123MP0000465_gastrointestinal_hemorrhage0.23737985
124MP0003329_amyloid_beta_deposits0.22364306
125MP0006054_spinal_hemorrhage0.22167287
126MP0000432_abnormal_head_morphology0.19734989
127MP0003300_gastrointestinal_ulcer0.19108663
128MP0005666_abnormal_adipose_tissue0.17112326
129MP0004019_abnormal_vitamin_homeostasis0.16945918
130MP0003935_abnormal_craniofacial_develop0.16372716
131MP0001879_abnormal_lymphatic_vessel0.14727350
132MP0005367_renal/urinary_system_phenotyp0.14506512
133MP0000516_abnormal_urinary_system0.14506512
134MP0005375_adipose_tissue_phenotype0.14254593
135MP0002166_altered_tumor_susceptibility0.14230520
136MP0003448_altered_tumor_morphology0.13900938
137MP0002006_tumorigenesis0.13794955
138MP0004742_abnormal_vestibular_system0.13706235
139MP0003638_abnormal_response/metabolism_0.12892073
140MP0005076_abnormal_cell_differentiation0.12621265
141MP0009384_cardiac_valve_regurgitation0.12584711
142MP0000604_amyloidosis0.11245715
143MP0004858_abnormal_nervous_system0.10764455
144MP0000751_myopathy0.10189890
145MP0002233_abnormal_nose_morphology0.10030453
146MP0003011_delayed_dark_adaptation0.10019293
147MP0005193_abnormal_anterior_eye0.09434635
148MP0001958_emphysema0.09147944
149MP0000733_abnormal_muscle_development0.08744706
150MP0003045_fibrosis0.08450676
151MP0003075_altered_response_to0.07998841
152MP0005508_abnormal_skeleton_morphology0.06792181
153MP0000462_abnormal_digestive_system0.06732650
154MP0000013_abnormal_adipose_tissue0.06471225
155MP0006138_congestive_heart_failure0.05915544

Predicted human phenotypes

RankGene SetZ-score
1Pili torti (HP:0003777)8.97184683
2Nail dystrophy (HP:0008404)7.40558697
3Severe visual impairment (HP:0001141)6.33464918
4Abnormality of nail color (HP:0100643)6.15041762
5Abnormal hair laboratory examination (HP:0003328)5.67996225
6Fragile nails (HP:0001808)5.52890998
7Fine hair (HP:0002213)5.33117555
8Alopecia of scalp (HP:0002293)4.87596349
9Palmoplantar hyperkeratosis (HP:0000972)4.78352559
10Onycholysis (HP:0001806)4.64259014
11Dynein arm defect of respiratory motile cilia (HP:0012255)4.56194291
12Absent/shortened dynein arms (HP:0200106)4.56194291
13Palmar hyperkeratosis (HP:0010765)4.50153354
14Increased IgE level (HP:0003212)4.46692072
15Thick nail (HP:0001805)4.37618700
16Follicular hyperkeratosis (HP:0007502)4.37155522
17Plantar hyperkeratosis (HP:0007556)4.35691350
18Absent eyebrow (HP:0002223)4.28721563
19Right ventricular cardiomyopathy (HP:0011663)4.11369947
20Bony spicule pigmentary retinopathy (HP:0007737)3.93894526
21Attenuation of retinal blood vessels (HP:0007843)3.83524851
22Asymmetric septal hypertrophy (HP:0001670)3.70293263
23Erythema (HP:0010783)3.54329426
24Absent hair (HP:0002298)3.54002620
25Sparse eyelashes (HP:0000653)3.53546302
26Abnormal ciliary motility (HP:0012262)3.49531735
27Hyperkalemia (HP:0002153)3.47513806
28Tubulointerstitial nephritis (HP:0001970)3.37785014
29Abnormal respiratory motile cilium physiology (HP:0012261)3.37627838
30Oral leukoplakia (HP:0002745)3.29112004
31Abnormal respiratory motile cilium morphology (HP:0005938)3.27642219
32Abnormal respiratory epithelium morphology (HP:0012253)3.27642219
33Milia (HP:0001056)3.14689155
34Abnormality of the frontal sinuses (HP:0002687)3.13324206
35Nasal polyposis (HP:0100582)3.13065102
36Resting tremor (HP:0002322)3.12897626
37Amelogenesis imperfecta (HP:0000705)3.07628171
38Infertility (HP:0000789)3.00661606
39Abnormality of macular pigmentation (HP:0008002)3.00589877
40Parakeratosis (HP:0001036)3.00387850
41Erythroderma (HP:0001019)2.98681039
42Chronic hepatic failure (HP:0100626)2.96679448
43Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.89532362
44Abnormal rod and cone electroretinograms (HP:0008323)2.88894577
45Bell-shaped thorax (HP:0001591)2.84421315
46Enlarged epiphyses (HP:0010580)2.83662901
47Facial shape deformation (HP:0011334)2.80266264
48Potter facies (HP:0002009)2.80266264
49Male infertility (HP:0003251)2.78946666
50Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.71173929
51Curly hair (HP:0002212)2.70963028
52Congenital, generalized hypertrichosis (HP:0004540)2.70432336
53Cone-rod dystrophy (HP:0000548)2.67844390
54Abnormality of the axillary hair (HP:0100134)2.67664364
55Abnormality of secondary sexual hair (HP:0009888)2.67664364
56Hypoplastic ischia (HP:0003175)2.65354533
57Ridged nail (HP:0001807)2.62030119
58Congenital ichthyosiform erythroderma (HP:0007431)2.59342845
59Intention tremor (HP:0002080)2.55319264
60Abnormality of the nasal mucosa (HP:0000433)2.52209515
61Aplasia cutis congenita (HP:0001057)2.47053683
62Aplasia/Hypoplasia of the earlobes (HP:0009906)2.43230752
63Neck muscle weakness (HP:0000467)2.42717248
64Dry hair (HP:0011359)2.38491779
65Abnormal blistering of the skin (HP:0008066)2.37141810
66Natal tooth (HP:0000695)2.33050274
67Abnormality of the ischium (HP:0003174)2.32608442
68Azoospermia (HP:0000027)2.29461105
69Torticollis (HP:0000473)2.27982372
70Abnormal spermatogenesis (HP:0008669)2.25884368
71Advanced eruption of teeth (HP:0006288)2.25475237
72Abnormality of the costochondral junction (HP:0000919)2.11879873
73Corneal erosion (HP:0200020)2.10254665
74Hypoplasia of the thymus (HP:0000778)2.10079242
75Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.09515247
76Hypohidrosis (HP:0000966)2.09001127
77Progressive sensorineural hearing impairment (HP:0000408)2.08554876
78Impulsivity (HP:0100710)2.04633534
79Palmoplantar keratoderma (HP:0000982)2.02307626
80Hypotrichosis (HP:0001006)14.9143784
81Slow-growing hair (HP:0002217)11.2747789
82Abnormality of hair growth rate (HP:0011363)11.2747789
83Woolly hair (HP:0002224)11.0203916
84Brittle hair (HP:0002299)10.5432819
85Ventricular tachycardia (HP:0004756)1.97425993
86Renal dysplasia (HP:0000110)1.96824180
87Hypoalphalipoproteinemia (HP:0003233)1.95750598
88Postural instability (HP:0002172)1.93250032
89Craniofacial dystonia (HP:0012179)1.92319765
90Abnormality of potassium homeostasis (HP:0011042)1.90995327
91Pruritus (HP:0000989)1.90126835
92Concave nail (HP:0001598)1.86640928
93Abnormal urine output (HP:0012590)1.86186705
94Rhinitis (HP:0012384)1.84668202
95Double outlet right ventricle (HP:0001719)1.83705553
96Congenital malformation of the right heart (HP:0011723)1.83705553
97Difficulty walking (HP:0002355)1.83281886
98Abnormality of the pupil (HP:0000615)1.81697002
99Abnormality of the parietal bone (HP:0002696)1.79982111
100Portal hypertension (HP:0001409)1.78770626
101Abnormality of the dental root (HP:0006486)1.76415283
102Taurodontia (HP:0000679)1.76415283
103Abnormality of permanent molar morphology (HP:0011071)1.76415283
104Stage 5 chronic kidney disease (HP:0003774)1.75982064
105Abnormality of dental color (HP:0011073)1.75876328
106Insulin-resistant diabetes mellitus (HP:0000831)1.75875217
107Focal dystonia (HP:0004373)1.75593231
108Conjunctival hamartoma (HP:0100780)1.75056175
109Abnormality of molar (HP:0011077)1.73941462
110Abnormality of molar morphology (HP:0011070)1.73941462
111Generalized aminoaciduria (HP:0002909)1.73019110
112Ventricular fibrillation (HP:0001663)1.71996595
113Widely patent fontanelles and sutures (HP:0004492)1.69749661
114Absent eyelashes (HP:0000561)1.68068428
115Abnormality of renal excretion (HP:0011036)1.66810454
116Hyporeflexia of lower limbs (HP:0002600)1.64652284
117Renovascular hypertension (HP:0100817)1.64245114
118Progressive cerebellar ataxia (HP:0002073)1.64056626
119Recurrent corneal erosions (HP:0000495)1.61691236
120Abnormality of the hepatic vasculature (HP:0006707)1.61019017
121Nephronophthisis (HP:0000090)1.58621276
122Epiphyseal dysplasia (HP:0002656)1.58313426
123Abnormality of the neuromuscular junction (HP:0003398)1.58282087
124Fatigable weakness (HP:0003473)1.58282087
125Chronic bronchitis (HP:0004469)1.57375812
126Tubulointerstitial abnormality (HP:0001969)1.55999198
127Blepharitis (HP:0000498)1.55825532
128Abnormality of the dental pulp (HP:0006479)1.54120186
129Amniotic constriction ring (HP:0009775)1.48499978
130Abnormality of placental membranes (HP:0011409)1.48499978
131Acanthosis nigricans (HP:0000956)1.46072050
132Unilateral renal agenesis (HP:0000122)1.46044520
133Sudden death (HP:0001699)1.45878823
134Lip pit (HP:0100267)1.44563508
135Abnormality of the aortic arch (HP:0012303)1.44454217
136Heterogeneous (HP:0001425)1.42782167
137Carious teeth (HP:0000670)1.38233689
138Gangrene (HP:0100758)1.38170446
139Keratoconjunctivitis sicca (HP:0001097)1.37559513
140Distal lower limb muscle weakness (HP:0009053)1.36163237
141Ectropion (HP:0000656)1.35928303
142Achilles tendon contracture (HP:0001771)1.34117861
143Round ear (HP:0100830)1.33758454
144Craniofacial hyperostosis (HP:0004493)1.33354568
145Anonychia (HP:0001798)1.31005488
146Autoamputation (HP:0001218)1.30867757
147Hypergammaglobulinemia (HP:0010702)1.29169597
148Abnormality of the fingernails (HP:0001231)1.26202671
149Abnormality of the Achilles tendon (HP:0005109)1.25931262
150Type 1 muscle fiber predominance (HP:0003803)1.25105272
151Atrophic scars (HP:0001075)1.23843594
152Variable expressivity (HP:0003828)1.20892982
153Keratoconjunctivitis (HP:0001096)1.20829500
154Increased connective tissue (HP:0009025)1.20110390
155Neonatal onset (HP:0003623)1.19736818
156Sparse scalp hair (HP:0002209)1.18182507
157Lack of skin elasticity (HP:0100679)1.17338953
158Selective tooth agenesis (HP:0001592)1.17023623
159Widely spaced teeth (HP:0000687)1.16589030
160Laryngomalacia (HP:0001601)1.14845091
161Abnormality of the gastric mucosa (HP:0004295)1.10008316

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.25271058
2EPHA24.32408286
3MAPKAPK34.17453243
4FER4.05814417
5ERN13.81574629
6INSRR3.78574509
7MAP4K23.72113840
8MAP3K63.53338184
9EPHB23.21543591
10PNCK3.11406600
11PLK23.03670214
12TAOK13.02971168
13BRD42.89986892
14MAP3K32.84359288
15TRIB32.66162230
16LATS12.56789249
17MAP3K22.44706039
18MAPK152.36299143
19CAMK1G2.20945260
20PRKD32.11688010
21MAP3K112.04769223
22RPS6KB22.04043134
23PIK3CG1.94137025
24TTN1.91867691
25EEF2K1.84658487
26WNK11.74989277
27MAP2K61.73785715
28PDPK11.64396790
29EPHB11.62832536
30LATS21.61396405
31PDK11.49527688
32FGFR21.49161027
33BCR1.41150707
34NME11.38801125
35CDK121.37562222
36CDK71.32567354
37FGFR11.30018278
38MAP3K11.27677656
39RIPK11.22729633
40FGFR41.22702286
41NEK61.22607078
42MST1R1.22492221
43CDK61.19920027
44KSR21.19105910
45MAP2K31.18507004
46BMX1.17672554
47FGFR31.13462814
48PKN21.12988837
49MAPKAPK21.07654146
50BLK1.06583624
51PDGFRA1.06478709
52PTK61.01589909
53LRRK21.01294363
54MAP3K71.01276547
55PBK1.00494745
56PTK2B0.97591050
57CAMK1D0.90435387
58SIK10.90005875
59MAP3K90.87666914
60RPS6KA40.85479343
61MAP2K40.81865363
62PRKG20.79711686
63PTK20.79052963
64MAP2K10.77859974
65STK380.75268639
66PRKAA20.75165562
67UHMK10.73844984
68TNIK0.71447194
69STK390.71413244
70STK38L0.71219066
71PIM20.70971059
72DYRK1B0.70599805
73MET0.69912715
74PRKD10.69754853
75TESK10.67984804
76ROCK10.67529863
77PAK40.67497862
78DDR20.65346190
79PAK30.65050575
80PRKG10.65024158
81RPS6KA20.64132948
82OBSCN0.63090719
83CDK190.62730162
84BMPR1B0.61845054
85TRPM70.60435266
86ERBB40.58926698
87BRAF0.58026357
88AKT30.57619174
89MAP3K100.56432548
90PRKCI0.55763949
91NTRK20.54867492
92MAP3K50.54342869
93TGFBR10.54113905
94CDK30.52890664
95PRKCH0.52642592
96NEK10.52494799
97TYRO30.51808893
98CAMK10.49305901
99ALK0.49229949
100WNK40.49206242
101RET0.48722070
102SIK20.48533238
103ERBB20.47419980
104EPHA30.46054663
105PAK20.46042359
106JAK10.45523767
107PAK60.44886285
108RPS6KA10.44458028
109MAPK120.43270776
110RPS6KA60.42796561
111TIE10.42717858
112MST40.42520908
113GSK3A0.41572576
114CSNK1E0.40333630
115SGK4940.40171885
116SGK2230.40171885
117GSK3B0.40124478
118TYK20.39923215
119MUSK0.38154540
120MAP2K20.36581481
121ERBB30.36164798
122MAPK10.36144692
123OXSR10.35532961
124RPS6KL10.34267375
125RPS6KC10.34267375
126CDK10.33656709
127JAK20.33602663
128CDK20.33200585
129PRKCG0.33117127
130MYLK0.32886026
131PHKG20.31446498
132PHKG10.31446498
133LIMK10.31288778
134MARK10.31233801
135MAPK80.30623675
136ILK0.30196667
137MTOR0.30190652
138CAMK40.29526199
139SGK10.29379447
140CDK40.29099319
141FRK0.28532913
142FYN0.28481700
143MAP3K80.28478733
144ACVR1B0.26457071
145PRKCZ0.26379218
146GRK60.25913803
147CSNK1A10.24362243
148SRC0.24122352
149TGFBR20.24059391
150IKBKB0.24008130
151STK110.22572528
152HCK0.22569193
153CLK10.22320669
154CSNK1D0.22290343
155PRKCB0.22199067
156DMPK0.21997096
157ROCK20.21415994
158PKN10.21313590
159ADRBK20.20494582
160MAPK140.20075101
161PINK10.20039983
162MARK20.19728595
163MAPK110.19264004
164PRKCE0.17115724
165NTRK30.16897668
166MAPK100.16285974
167LMTK20.16210881
168PRKACA0.16098010
169RIPK40.14684181
170AKT10.14469102
171BMPR20.14051213
172CHEK10.12162976
173TESK20.11892927

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000616.06598935
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.82212187
3Linoleic acid metabolism_Homo sapiens_hsa005914.78960601
4Fat digestion and absorption_Homo sapiens_hsa049753.11446243
5Fatty acid elongation_Homo sapiens_hsa000622.82024102
6Ether lipid metabolism_Homo sapiens_hsa005652.53408364
7Basal cell carcinoma_Homo sapiens_hsa052172.26864618
8Arachidonic acid metabolism_Homo sapiens_hsa005901.86359391
9Phenylalanine metabolism_Homo sapiens_hsa003601.81218233
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.80137729
11Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.78083414
12VEGF signaling pathway_Homo sapiens_hsa043701.71454908
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.67110249
14Melanogenesis_Homo sapiens_hsa049161.61202539
15Vitamin digestion and absorption_Homo sapiens_hsa049771.59650591
16Axon guidance_Homo sapiens_hsa043601.54278866
17Allograft rejection_Homo sapiens_hsa053301.53043163
18Type I diabetes mellitus_Homo sapiens_hsa049401.50188290
19Autoimmune thyroid disease_Homo sapiens_hsa053201.49525580
20Hedgehog signaling pathway_Homo sapiens_hsa043401.42527468
21Graft-versus-host disease_Homo sapiens_hsa053321.38970294
22Bladder cancer_Homo sapiens_hsa052191.38601566
23Glioma_Homo sapiens_hsa052141.36647886
24Retinol metabolism_Homo sapiens_hsa008301.35637686
25Histidine metabolism_Homo sapiens_hsa003401.35435188
26Antigen processing and presentation_Homo sapiens_hsa046121.34390864
27Thyroid cancer_Homo sapiens_hsa052161.33460815
28Proteoglycans in cancer_Homo sapiens_hsa052051.31398187
29Vascular smooth muscle contraction_Homo sapiens_hsa042701.30529041
30Hippo signaling pathway_Homo sapiens_hsa043901.30037391
31Caffeine metabolism_Homo sapiens_hsa002321.29406392
32GnRH signaling pathway_Homo sapiens_hsa049121.24694985
33Taste transduction_Homo sapiens_hsa047421.23291163
34Acute myeloid leukemia_Homo sapiens_hsa052211.16980298
35Tight junction_Homo sapiens_hsa045301.16346493
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16213017
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13753974
38Glycerolipid metabolism_Homo sapiens_hsa005611.10509128
39Dorso-ventral axis formation_Homo sapiens_hsa043201.09321754
40Pancreatic secretion_Homo sapiens_hsa049721.08560360
41Mineral absorption_Homo sapiens_hsa049781.08302076
42Type II diabetes mellitus_Homo sapiens_hsa049301.05297692
43Long-term potentiation_Homo sapiens_hsa047201.04038770
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.03535087
45PPAR signaling pathway_Homo sapiens_hsa033201.02272747
46ECM-receptor interaction_Homo sapiens_hsa045120.99920431
47Adherens junction_Homo sapiens_hsa045200.99680361
48Arginine biosynthesis_Homo sapiens_hsa002200.98749290
49Steroid biosynthesis_Homo sapiens_hsa001000.98287823
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.97859347
51Nitrogen metabolism_Homo sapiens_hsa009100.97669062
52Arginine and proline metabolism_Homo sapiens_hsa003300.96037672
53Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.95843824
54Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93813051
55Tyrosine metabolism_Homo sapiens_hsa003500.91290843
56Glycerophospholipid metabolism_Homo sapiens_hsa005640.91198962
57Viral myocarditis_Homo sapiens_hsa054160.91176211
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.90982524
59Non-small cell lung cancer_Homo sapiens_hsa052230.90073656
60Endometrial cancer_Homo sapiens_hsa052130.89681910
61Pertussis_Homo sapiens_hsa051330.87381529
62Circadian entrainment_Homo sapiens_hsa047130.85189789
63Endocytosis_Homo sapiens_hsa041440.84946227
64Long-term depression_Homo sapiens_hsa047300.83712919
65Ras signaling pathway_Homo sapiens_hsa040140.82655576
66Estrogen signaling pathway_Homo sapiens_hsa049150.82094883
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.81406983
68Wnt signaling pathway_Homo sapiens_hsa043100.80282047
69Aldosterone synthesis and secretion_Homo sapiens_hsa049250.79196738
70Amoebiasis_Homo sapiens_hsa051460.77958342
71Cardiac muscle contraction_Homo sapiens_hsa042600.77162793
72beta-Alanine metabolism_Homo sapiens_hsa004100.76390918
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.75119251
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75094553
75Calcium signaling pathway_Homo sapiens_hsa040200.74567701
76RNA transport_Homo sapiens_hsa030130.73396355
77Staphylococcus aureus infection_Homo sapiens_hsa051500.72485843
78cAMP signaling pathway_Homo sapiens_hsa040240.71962881
79Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.71328115
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.69872513
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69632561
82Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68558507
83Inositol phosphate metabolism_Homo sapiens_hsa005620.67567626
84Gastric acid secretion_Homo sapiens_hsa049710.67506689
85Renin secretion_Homo sapiens_hsa049240.66379143
86MicroRNAs in cancer_Homo sapiens_hsa052060.66006330
87Phototransduction_Homo sapiens_hsa047440.65944624
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.65480853
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64510779
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63870831
91Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.63575550
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63414796
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.61312394
94Insulin resistance_Homo sapiens_hsa049310.61008808
95Synaptic vesicle cycle_Homo sapiens_hsa047210.60054799
96Fatty acid metabolism_Homo sapiens_hsa012120.59703836
97Hepatitis C_Homo sapiens_hsa051600.58679838
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.57243205
99Renin-angiotensin system_Homo sapiens_hsa046140.57117325
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56926680
101Oocyte meiosis_Homo sapiens_hsa041140.56853376
102Rap1 signaling pathway_Homo sapiens_hsa040150.55920481
103Gap junction_Homo sapiens_hsa045400.53819439
104ABC transporters_Homo sapiens_hsa020100.53716890
105Focal adhesion_Homo sapiens_hsa045100.53687830
106Protein digestion and absorption_Homo sapiens_hsa049740.53552444
107Salmonella infection_Homo sapiens_hsa051320.53360057
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.51538211
109TGF-beta signaling pathway_Homo sapiens_hsa043500.50632261
110Serotonergic synapse_Homo sapiens_hsa047260.50160584
111Oxytocin signaling pathway_Homo sapiens_hsa049210.49695940
112Renal cell carcinoma_Homo sapiens_hsa052110.49455573
113Platelet activation_Homo sapiens_hsa046110.49348012
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48786092
115Influenza A_Homo sapiens_hsa051640.48126761
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47776788
117Salivary secretion_Homo sapiens_hsa049700.46327307
118ErbB signaling pathway_Homo sapiens_hsa040120.45957040
119Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.44442184
120Butanoate metabolism_Homo sapiens_hsa006500.44428204
121Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44360368
122Glutamatergic synapse_Homo sapiens_hsa047240.44079011
123Morphine addiction_Homo sapiens_hsa050320.43871266
124Fatty acid degradation_Homo sapiens_hsa000710.43736804
125Maturity onset diabetes of the young_Homo sapiens_hsa049500.43383655
126Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.42254650
127Sphingolipid metabolism_Homo sapiens_hsa006000.42167583
128Chemical carcinogenesis_Homo sapiens_hsa052040.41661936
129Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41191345
130Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41117065
131Chronic myeloid leukemia_Homo sapiens_hsa052200.40541756
132Amphetamine addiction_Homo sapiens_hsa050310.40381497
133p53 signaling pathway_Homo sapiens_hsa041150.40264765
134Tuberculosis_Homo sapiens_hsa051520.38101283
135Toxoplasmosis_Homo sapiens_hsa051450.37447680
136Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37002927
137Prion diseases_Homo sapiens_hsa050200.36970007
138Peroxisome_Homo sapiens_hsa041460.36503735
139Insulin signaling pathway_Homo sapiens_hsa049100.36247479
140Notch signaling pathway_Homo sapiens_hsa043300.36211242
141Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36005639
142Olfactory transduction_Homo sapiens_hsa047400.35580271
143Melanoma_Homo sapiens_hsa052180.34853476
144Prolactin signaling pathway_Homo sapiens_hsa049170.34830701
145Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34185192
146Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32707269
147Nicotine addiction_Homo sapiens_hsa050330.30966404
148MAPK signaling pathway_Homo sapiens_hsa040100.30594684
149cGMP-PKG signaling pathway_Homo sapiens_hsa040220.29126008
150Insulin secretion_Homo sapiens_hsa049110.28932578
151Carbohydrate digestion and absorption_Homo sapiens_hsa049730.26863798
152Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.25290605
153Steroid hormone biosynthesis_Homo sapiens_hsa001400.24409058
154Bile secretion_Homo sapiens_hsa049760.23735232
155Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18360948
156Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.18031859
157Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.16043394

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