KRT31

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1adhesion of symbiont to host cell (GO:0044650)9.82762796
2virion attachment to host cell (GO:0019062)9.82762796
3citrulline biosynthetic process (GO:0019240)8.73544320
4peptide cross-linking (GO:0018149)8.38200656
5hair follicle morphogenesis (GO:0031069)8.30301915
6adhesion of symbiont to host (GO:0044406)8.29777760
7intermediate filament cytoskeleton organization (GO:0045104)6.61583337
8cell wall macromolecule metabolic process (GO:0044036)6.40581414
9cell wall macromolecule catabolic process (GO:0016998)6.40581414
10intermediate filament-based process (GO:0045103)6.40545421
11establishment of skin barrier (GO:0061436)6.05951224
12keratinocyte differentiation (GO:0030216)5.81320221
13citrulline metabolic process (GO:0000052)5.74988687
14long-chain fatty acid biosynthetic process (GO:0042759)5.64563646
15* epidermis development (GO:0008544)5.62300713
16molting cycle process (GO:0022404)5.39064442
17hair cycle process (GO:0022405)5.39064442
18regulation of water loss via skin (GO:0033561)5.35653190
19linoleic acid metabolic process (GO:0043651)5.35008304
20bundle of His cell to Purkinje myocyte communication (GO:0086069)5.08373307
21hemidesmosome assembly (GO:0031581)4.97472278
22skin morphogenesis (GO:0043589)4.86837087
23fructose metabolic process (GO:0006000)4.85802875
24peptidyl-arginine modification (GO:0018195)4.78127800
25long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.54042115
26epidermal cell differentiation (GO:0009913)4.53556767
27long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.24547512
28fatty-acyl-CoA biosynthetic process (GO:0046949)4.07126628
29molting cycle (GO:0042303)34.6104731
30hair cycle (GO:0042633)34.6104731
31tooth mineralization (GO:0034505)3.93668124
32anatomical structure regression (GO:0060033)3.93528541
33natural killer cell activation involved in immune response (GO:0002323)3.90701349
34keratinocyte development (GO:0003334)3.86543767
35lipoxygenase pathway (GO:0019372)3.85358185
36cellular response to exogenous dsRNA (GO:0071360)3.69527369
37retinol metabolic process (GO:0042572)3.67523638
38multicellular organismal water homeostasis (GO:0050891)3.63394831
39digestive tract morphogenesis (GO:0048546)3.53879392
40negative regulation of keratinocyte proliferation (GO:0010839)3.48765528
41regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.47241689
42regulation of keratinocyte differentiation (GO:0045616)3.35807077
43thioester biosynthetic process (GO:0035384)3.35092718
44acyl-CoA biosynthetic process (GO:0071616)3.35092718
45fatty-acyl-CoA metabolic process (GO:0035337)3.34340134
46phosphatidylinositol acyl-chain remodeling (GO:0036149)3.32202054
47positive regulation of hair follicle development (GO:0051798)3.30226311
48positive regulation of hair cycle (GO:0042635)3.30226311
49hair follicle development (GO:0001942)3.24402327
50negative regulation of establishment of protein localization to plasma membrane (GO:0090005)3.14008668
51regulation of hair follicle development (GO:0051797)3.10326408
52phosphatidylserine acyl-chain remodeling (GO:0036150)3.03944432
53cardiovascular system development (GO:0072358)3.03390567
54water homeostasis (GO:0030104)3.00086760
55bone trabecula formation (GO:0060346)2.95553398
56CDP-diacylglycerol biosynthetic process (GO:0016024)2.90375832
57regulation of helicase activity (GO:0051095)2.87063995
58proximal/distal pattern formation (GO:0009954)2.86435721
59retina layer formation (GO:0010842)2.84881386
60positive regulation of keratinocyte differentiation (GO:0045618)2.84165316
61cerebellar granule cell differentiation (GO:0021707)2.82218603
62positive regulation of epidermis development (GO:0045684)2.79348476
63phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.77742657
64alpha-linolenic acid metabolic process (GO:0036109)2.76769112
65atrioventricular valve morphogenesis (GO:0003181)2.74291021
66gap junction assembly (GO:0016264)2.73489502
67ectoderm development (GO:0007398)2.73063212
68positive regulation of meiotic cell cycle (GO:0051446)2.72989707
69regulation of hair cycle (GO:0042634)2.70499477
70positive regulation of SMAD protein import into nucleus (GO:0060391)2.70490344
71regulation of sequestering of triglyceride (GO:0010889)2.67499074
72* epithelium development (GO:0060429)2.66044312
73CDP-diacylglycerol metabolic process (GO:0046341)2.64351339
74fatty acid elongation (GO:0030497)2.63435230
75primary alcohol metabolic process (GO:0034308)2.62047592
76regulation of epidermal cell differentiation (GO:0045604)2.60177247
77positive regulation of chemokine secretion (GO:0090197)2.60018369
78negative regulation of protein localization to plasma membrane (GO:1903077)2.59649854
79regulation of defense response to virus by host (GO:0050691)2.55094247
80defense response to fungus (GO:0050832)2.54889771
81mating behavior (GO:0007617)2.52836709
82regulation of epidermis development (GO:0045682)2.52239549
83negative regulation of cell size (GO:0045792)2.52045571
84ventricular cardiac muscle cell action potential (GO:0086005)2.45778529
85wound healing, spreading of epidermal cells (GO:0035313)2.45735288
86epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.43734675
87negative regulation of cell fate specification (GO:0009996)2.43248374
88pre-miRNA processing (GO:0031054)2.42593247
89triglyceride biosynthetic process (GO:0019432)2.40197321
90positive regulation of osteoblast proliferation (GO:0033690)2.35246885
91disruption of cells of other organism (GO:0044364)2.35132776
92killing of cells of other organism (GO:0031640)2.35132776
93regulation of chemokine secretion (GO:0090196)2.31233767
94positive regulation of epidermal cell differentiation (GO:0045606)2.30018794
95phosphatidylserine metabolic process (GO:0006658)2.29537441
96regulation of mesenchymal cell apoptotic process (GO:2001053)2.26279361
97negative regulation of glial cell proliferation (GO:0060253)2.25742665
98acylglycerol biosynthetic process (GO:0046463)2.25732482
99neutral lipid biosynthetic process (GO:0046460)2.25732482
100lymph vessel development (GO:0001945)2.25161143
101regulation of cardioblast differentiation (GO:0051890)2.25158205
102cell surface receptor signaling pathway involved in heart development (GO:0061311)2.24936766
103skin development (GO:0043588)2.24311157
104actin-myosin filament sliding (GO:0033275)2.20150282
105muscle filament sliding (GO:0030049)2.20150282
106phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.19949420
107positive regulation of smoothened signaling pathway (GO:0045880)2.19153021
108ovulation cycle (GO:0042698)2.18454166
109cranial suture morphogenesis (GO:0060363)2.14902010
110myotube differentiation (GO:0014902)2.12256899
111positive regulation of monocyte chemotaxis (GO:0090026)2.10052375
112response to phenylpropanoid (GO:0080184)2.09628646
113outflow tract septum morphogenesis (GO:0003148)2.07748830
114regulation of SMAD protein import into nucleus (GO:0060390)2.06193252
115negative regulation of epidermis development (GO:0045683)2.04730746
116epithelial cell-cell adhesion (GO:0090136)2.02517812
117sarcoplasmic reticulum calcium ion transport (GO:0070296)2.02440237
118aging (GO:0007568)2.02384662
119regulation of Cdc42 GTPase activity (GO:0043088)2.01564340
120cell migration in hindbrain (GO:0021535)2.00926438
121regulation of ruffle assembly (GO:1900027)2.00765767
122intermediate filament organization (GO:0045109)12.0448391
123keratinization (GO:0031424)11.7266381
124desmosome organization (GO:0002934)10.1233577
125regulation of heart rate by cardiac conduction (GO:0086091)1.99981106
126thioester metabolic process (GO:0035383)1.98171333
127acyl-CoA metabolic process (GO:0006637)1.98171333
128one-carbon compound transport (GO:0019755)1.98087834
129phosphatidylcholine acyl-chain remodeling (GO:0036151)1.97832219
130planar cell polarity pathway involved in neural tube closure (GO:0090179)1.97468791
131cytoskeletal anchoring at plasma membrane (GO:0007016)1.97164486
132regulation of keratinocyte proliferation (GO:0010837)1.96423952
133regulation of Wnt signaling pathway involved in heart development (GO:0003307)1.96042123
134positive regulation of regulated secretory pathway (GO:1903307)1.95063768
135peptidyl-lysine dimethylation (GO:0018027)1.94855012
136monoubiquitinated protein deubiquitination (GO:0035520)1.91575098
137carnitine metabolic process (GO:0009437)1.91194650
138ephrin receptor signaling pathway (GO:0048013)1.87300126
139cell-substrate junction assembly (GO:0007044)1.83905802
140cell communication involved in cardiac conduction (GO:0086065)1.82267797
141non-canonical Wnt signaling pathway (GO:0035567)1.81569364
142regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)1.80519906
143regulation of cardioblast proliferation (GO:0003264)1.80488996
144regulation of secondary heart field cardioblast proliferation (GO:0003266)1.80488996
145wound healing, spreading of cells (GO:0044319)1.76369143
146regulation of transforming growth factor beta2 production (GO:0032909)1.75875738
147coronary vasculature morphogenesis (GO:0060977)1.72749060
148keratinocyte proliferation (GO:0043616)1.69941138
149alditol phosphate metabolic process (GO:0052646)1.69112092
150negative regulation of cell fate commitment (GO:0010454)1.66456277
151primary alcohol catabolic process (GO:0034310)1.65462978
152very long-chain fatty acid metabolic process (GO:0000038)1.63708380
153antigen processing and presentation of endogenous peptide antigen (GO:0002483)1.61875901
154antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)1.61875901
155G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071991.61733255
156negative regulation of epidermal cell differentiation (GO:0045605)1.61173437
157regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901211.61093750
158cardiac right ventricle morphogenesis (GO:0003215)1.60334087

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.64204609
2CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.83121033
3* P63_26484246_Chip-Seq_KERATINOCYTES_Human3.42850055
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.00474079
5CTCF_20526341_ChIP-Seq_ESCs_Human2.34040104
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.17497385
7BMI1_19503595_ChIP-Seq_MEFsC_Mouse2.11897449
8TP63_17297297_ChIP-ChIP_HaCaT_Human12.6038050
9* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.96276068
10PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.87758881
11E2F1_20622854_ChIP-Seq_HELA_Human1.85666318
12EZH2_18974828_ChIP-Seq_MESCs_Mouse1.76019355
13RNF2_18974828_ChIP-Seq_MESCs_Mouse1.76019355
14P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.73418967
15EGR1_19032775_ChIP-ChIP_M12_Human1.73169435
16CSB_26484114_Chip-Seq_FIBROBLAST_Human1.72880928
17VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.72504357
18NANOG_20526341_ChIP-Seq_ESCs_Human1.69121357
19DROSHA_22980978_ChIP-Seq_HELA_Human1.68245226
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.68111246
21* TAF2_19829295_ChIP-Seq_ESCs_Human1.64070570
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.63947545
23CTCF_27219007_Chip-Seq_Bcells_Human1.62735797
24JARID2_20064375_ChIP-Seq_MESCs_Mouse1.62455454
25ERG_20517297_ChIP-Seq_VCAP_Human1.60919138
26* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.57802797
27EZH2_27304074_Chip-Seq_ESCs_Mouse1.57480368
28SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.56896764
29SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.56896764
30SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.56362615
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.55931373
32FOXO3_23340844_ChIP-Seq_DLD1_Human1.55683007
33TP53_20018659_ChIP-ChIP_R1E_Mouse1.53384121
34RACK7_27058665_Chip-Seq_MCF-7_Human1.52150213
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.49798971
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48525057
37ESR1_21235772_ChIP-Seq_MCF-7_Human1.48223872
38LXR_22292898_ChIP-Seq_THP-1_Human1.47082460
39DNAJC2_21179169_ChIP-ChIP_NT2_Human1.46072895
40YY1_22570637_ChIP-Seq_MALME-3M_Human1.45490810
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.45436556
42MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.45222825
43* TP63_22573176_ChIP-Seq_HFKS_Human1.44285100
44SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.43580379
45RNF2_27304074_Chip-Seq_NSC_Mouse1.41531560
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.40213428
47* P53_21459846_ChIP-Seq_SAOS-2_Human1.39581244
48ATF3_27146783_Chip-Seq_COLON_Human1.38223774
49UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.35708927
50ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.33734485
51SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.32791208
52ESR2_21235772_ChIP-Seq_MCF-7_Human1.32778055
53* BCL6_27268052_Chip-Seq_Bcells_Human1.31938341
54SRY_22984422_ChIP-ChIP_TESTIS_Rat1.31048113
55MTF2_20144788_ChIP-Seq_MESCs_Mouse1.30226422
56* BCOR_27268052_Chip-Seq_Bcells_Human1.25872123
57PHF8_20622854_ChIP-Seq_HELA_Human1.23592120
58KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.23366236
59SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.22269457
60GBX2_23144817_ChIP-Seq_PC3_Human1.21640342
61P68_20966046_ChIP-Seq_HELA_Human1.20509763
62KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.19596705
63SUZ12_27294783_Chip-Seq_ESCs_Mouse1.19339966
64CBX2_27304074_Chip-Seq_ESCs_Mouse1.15596986
65ELF1_20517297_ChIP-Seq_JURKAT_Human1.15400149
66GATA3_24758297_ChIP-Seq_MCF-7_Human1.13721767
67TRIM28_21343339_ChIP-Seq_HEK293_Human1.13121393
68PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.12174110
69TP63_23658742_ChIP-Seq_EP156T_Human1.12055458
70RING1B_27294783_Chip-Seq_NPCs_Mouse1.12016554
71ELK4_26923725_Chip-Seq_MESODERM_Mouse1.11439494
72E2F1_17053090_ChIP-ChIP_MCF-7_Human1.11027630
73GATA4_25053715_ChIP-Seq_YYC3_Human1.10705408
74RAC3_21632823_ChIP-Seq_H3396_Human1.10154788
75SMC4_20622854_ChIP-Seq_HELA_Human1.09847814
76TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08956554
77UBF1/2_26484160_Chip-Seq_HMECs_Human1.06977553
78JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05400814
79IKZF1_21737484_ChIP-ChIP_HCT116_Human1.03798943
80P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03751355
81SA1_27219007_Chip-Seq_ERYTHROID_Human1.03218471
82KLF5_25053715_ChIP-Seq_YYC3_Human1.02206759
83* CEBPB_22108803_ChIP-Seq_LS180_Human1.01596759
84SOX2_21211035_ChIP-Seq_LN229_Human1.00764778
85* ARNT_22903824_ChIP-Seq_MCF-7_Human1.00687933
86GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.00386674
87* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98956424
88RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98546564
89EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98045261
90TP53_18474530_ChIP-ChIP_U2OS_Human0.97827675
91DPY_21335234_ChIP-Seq_ESCs_Mouse0.96920192
92RAD21_21589869_ChIP-Seq_MESCs_Mouse0.96607685
93SPI1_20517297_ChIP-Seq_HL60_Human0.96202399
94TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95882672
95RXRA_24833708_ChIP-Seq_LIVER_Mouse0.94263826
96* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93230037
97FOXH1_21741376_ChIP-Seq_ESCs_Human0.92466139
98ERG_21242973_ChIP-ChIP_JURKAT_Human0.91514800
99GATA6_21074721_ChIP-Seq_CACO-2_Human0.90437313
100RUNX1_27514584_Chip-Seq_MCF-7_Human0.90009893
101CDX2_19796622_ChIP-Seq_MESCs_Mouse0.89855853
102RXR_22108803_ChIP-Seq_LS180_Human0.89032636
103* AHR_22903824_ChIP-Seq_MCF-7_Human0.88431388
104SMAD3_21741376_ChIP-Seq_ESCs_Human0.88318023
105RING1B_27294783_Chip-Seq_ESCs_Mouse0.87821182
106SOX2_20726797_ChIP-Seq_SW620_Human0.87665632
107EED_16625203_ChIP-ChIP_MESCs_Mouse0.87299817
108TBX20_22080862_ChIP-Seq_HEART_Mouse0.87065159
109TBX20_22328084_ChIP-Seq_HEART_Mouse0.87065159
110PIAS1_25552417_ChIP-Seq_VCAP_Human0.85465778
111CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.84785309
112NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.84592791
113* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84128437
114ZNF263_19887448_ChIP-Seq_K562_Human0.84100138
115AR_21572438_ChIP-Seq_LNCaP_Human0.83964853
116PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.82168086
117WT1_25993318_ChIP-Seq_PODOCYTE_Human0.81871865
118GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.81460087
119EZH2_22144423_ChIP-Seq_EOC_Human0.80505626
120RNF2_27304074_Chip-Seq_ESCs_Mouse0.80025992
121EZH2_27294783_Chip-Seq_ESCs_Mouse0.79885774
122VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.79561301
123ZNF217_24962896_ChIP-Seq_MCF-7_Human0.78796056
124ZFP281_18757296_ChIP-ChIP_E14_Mouse0.77896473
125RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.76326154
126ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.75901837
127PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.75597066
128FOXH1_21741376_ChIP-Seq_EPCs_Human0.75076174
129FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.75021633
130EP300_21415370_ChIP-Seq_HL-1_Mouse0.75000681
131ELK3_25401928_ChIP-Seq_HUVEC_Human0.74691060
132TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.74354152
133SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.72858004
134FOXA1_27270436_Chip-Seq_PROSTATE_Human0.72804505
135CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.71191274
136TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.71086372
137GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.70806626
138CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.70468933
139SMAD3_21741376_ChIP-Seq_HESCs_Human0.68869311
140CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.67449986
141PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.66320674
142SMC3_22415368_ChIP-Seq_MEFs_Mouse0.66033003
143AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.64604661
144SMAD3_21741376_ChIP-Seq_EPCs_Human0.64423045

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology7.60309172
2MP0002098_abnormal_vibrissa_morphology7.16215243
3MP0000647_abnormal_sebaceous_gland6.38253565
4MP0002796_impaired_skin_barrier5.96549927
5MP0005275_abnormal_skin_tensile5.21267517
6MP0010234_abnormal_vibrissa_follicle5.02312377
7MP0000383_abnormal_hair_follicle4.52631950
8MP0000377_abnormal_hair_follicle4.07116456
9MP0010678_abnormal_skin_adnexa3.98955839
10MP0005501_abnormal_skin_physiology3.72175887
11MP0003705_abnormal_hypodermis_morpholog3.69963385
12MP0000427_abnormal_hair_cycle3.47603677
13MP0002254_reproductive_system_inflammat3.17204776
14MP0001216_abnormal_epidermal_layer2.68256100
15MP0004381_abnormal_hair_follicle2.50452734
16MP0000367_abnormal_coat/_hair2.36488237
17MP0004947_skin_inflammation2.31198045
18MP0010771_integument_phenotype2.30812603
19MP0002060_abnormal_skin_morphology2.17881551
20MP0003453_abnormal_keratinocyte_physiol2.15437349
21MP0001243_abnormal_dermal_layer2.14799707
22MP0005084_abnormal_gallbladder_morpholo2.10420580
23MP0002234_abnormal_pharynx_morphology2.06640617
24MP0005377_hearing/vestibular/ear_phenot2.05664047
25MP0003878_abnormal_ear_physiology2.05664047
26MP0000467_abnormal_esophagus_morphology1.70703714
27MP0003252_abnormal_bile_duct1.70502888
28MP0009053_abnormal_anal_canal1.52332063
29MP0000762_abnormal_tongue_morphology1.51060057
30MP0009931_abnormal_skin_appearance1.50727982
31MP0003566_abnormal_cell_adhesion1.42261512
32MP0003941_abnormal_skin_development1.37407782
33MP0005409_darkened_coat_color1.25627954
34MP0002928_abnormal_bile_duct1.24214500
35MP0003646_muscle_fatigue1.12651050
36MP0008569_lethality_at_weaning1.04782673
37MP0004133_heterotaxia1.04122111
38MP0001191_abnormal_skin_condition1.00524000
39MP0001188_hyperpigmentation0.97469819
40MP0005408_hypopigmentation0.94545444
41MP0002095_abnormal_skin_pigmentation0.89321361
42MP0004185_abnormal_adipocyte_glucose0.88481610
43MP0004885_abnormal_endolymph0.88017696
44MP0005423_abnormal_somatic_nervous0.87621221
45MP0004264_abnormal_extraembryonic_tissu0.81836802
46MP0004145_abnormal_muscle_electrophysio0.79166719
47MP0006035_abnormal_mitochondrial_morpho0.78488722
48MP0001851_eye_inflammation0.78057646
49MP0001919_abnormal_reproductive_system0.77505500
50MP0008995_early_reproductive_senescence0.76101861
51MP0008438_abnormal_cutaneous_collagen0.75477717
52MP0000749_muscle_degeneration0.74838202
53MP0001849_ear_inflammation0.68755977
54MP0005187_abnormal_penis_morphology0.68492528
55MP0001346_abnormal_lacrimal_gland0.67765663
56MP0003315_abnormal_perineum_morphology0.67058825
57MP0001340_abnormal_eyelid_morphology0.65955285
58MP0003191_abnormal_cellular_cholesterol0.64622126
59MP0005647_abnormal_sex_gland0.64287263
60MP0010030_abnormal_orbit_morphology0.63714616
61MP0001270_distended_abdomen0.62792955
62MP0001661_extended_life_span0.62495364
63MP0000566_synostosis0.60165023
64MP0005220_abnormal_exocrine_pancreas0.59324706
65MP0000627_abnormal_mammary_gland0.57444068
66MP0002877_abnormal_melanocyte_morpholog0.57095551
67MP0005535_abnormal_body_temperature0.54812022
68MP0003880_abnormal_central_pattern0.53696229
69MP0009703_decreased_birth_body0.52758011
70MP0005451_abnormal_body_composition0.52487150
71MP0001485_abnormal_pinna_reflex0.51935273
72MP0002282_abnormal_trachea_morphology0.51788067
73MP0003755_abnormal_palate_morphology0.50868846
74MP0005023_abnormal_wound_healing0.49182616
75MP0000631_abnormal_neuroendocrine_gland0.47855428
76MP0009780_abnormal_chondrocyte_physiolo0.47848969
77MP0004270_analgesia0.46820471
78MP0001784_abnormal_fluid_regulation0.45346339
79MP0008260_abnormal_autophagy0.44472153
80MP0002970_abnormal_white_adipose0.43182578
81MP0002249_abnormal_larynx_morphology0.42621118
82MP0004036_abnormal_muscle_relaxation0.42570468
83MP0000678_abnormal_parathyroid_gland0.41044760
84MP0009379_abnormal_foot_pigmentation0.40974731
85MP0002111_abnormal_tail_morphology0.40259031
86MP0009672_abnormal_birth_weight0.39915075
87MP0004272_abnormal_basement_membrane0.38457964
88MP0002108_abnormal_muscle_morphology0.36818565
89MP0005075_abnormal_melanosome_morpholog0.36558420
90MP0000015_abnormal_ear_pigmentation0.35898468
91MP0005174_abnormal_tail_pigmentation0.34878746
92MP0003950_abnormal_plasma_membrane0.33419752
93MP0002177_abnormal_outer_ear0.31743596
94MP0003385_abnormal_body_wall0.31604422
95MP0000537_abnormal_urethra_morphology0.31265992
96MP0004087_abnormal_muscle_fiber0.30824579
97MP0010352_gastrointestinal_tract_polyps0.29993214
98MP0000759_abnormal_skeletal_muscle0.29711622
99MP0001984_abnormal_olfaction0.28118526
100MP0005620_abnormal_muscle_contractility0.28053147
101MP0004859_abnormal_synaptic_plasticity0.26440145
102MP0005248_abnormal_Harderian_gland0.26342442
103MP0009840_abnormal_foam_cell0.26061426
104MP0005381_digestive/alimentary_phenotyp0.25791310
105MP0002106_abnormal_muscle_physiology0.25705908
106MP0002697_abnormal_eye_size0.24978650
107MP0003300_gastrointestinal_ulcer0.24133532
108MP0002971_abnormal_brown_adipose0.23982675
109MP0006054_spinal_hemorrhage0.22974527
110MP0005369_muscle_phenotype0.22808534
111MP0005452_abnormal_adipose_tissue0.22317818
112MP0006138_congestive_heart_failure0.22310916
113MP0003763_abnormal_thymus_physiology0.22105259
114MP0003329_amyloid_beta_deposits0.21919009
115MP0002653_abnormal_ependyma_morphology0.21724583
116MP0000465_gastrointestinal_hemorrhage0.21262270
117MP0005389_reproductive_system_phenotype0.21229967
118MP0001879_abnormal_lymphatic_vessel0.20676300
119MP0000432_abnormal_head_morphology0.19319312
120MP0001958_emphysema0.18303063
121MP0004019_abnormal_vitamin_homeostasis0.17829951
122MP0002972_abnormal_cardiac_muscle0.17200125
123MP0004858_abnormal_nervous_system0.17153529
124MP0005503_abnormal_tendon_morphology0.17071001
125MP0003935_abnormal_craniofacial_develop0.16153906
126MP0000371_diluted_coat_color0.15591096
127MP0000516_abnormal_urinary_system0.15516801
128MP0005367_renal/urinary_system_phenotyp0.15516801
129MP0000750_abnormal_muscle_regeneration0.15411384
130MP0004484_altered_response_of0.15305780
131MP0009384_cardiac_valve_regurgitation0.14897158
132MP0003448_altered_tumor_morphology0.14895919
133MP0000751_myopathy0.14667453
134MP0005666_abnormal_adipose_tissue0.14425884
135MP0004742_abnormal_vestibular_system0.13993942
136MP0005330_cardiomyopathy0.13907530
137MP0000733_abnormal_muscle_development0.13877688
138MP0000462_abnormal_digestive_system0.13552993
139MP0005375_adipose_tissue_phenotype0.12632836
140MP0003638_abnormal_response/metabolism_0.12395275
141MP0005076_abnormal_cell_differentiation0.10592546
142MP0003045_fibrosis0.10310496
143MP0002233_abnormal_nose_morphology0.10191907
144MP0005193_abnormal_anterior_eye0.09619579
145MP0001542_abnormal_bone_strength0.09506650
146MP0000604_amyloidosis0.09321345
147MP0002006_tumorigenesis0.09034375
148MP0003011_delayed_dark_adaptation0.08557245
149MP0010368_abnormal_lymphatic_system0.07737588
150MP0005508_abnormal_skeleton_morphology0.07405755
151MP0003075_altered_response_to0.07385712
152MP0002166_altered_tumor_susceptibility0.06799732

Predicted human phenotypes

RankGene SetZ-score
1Pili torti (HP:0003777)8.98524893
2Nail dystrophy (HP:0008404)7.40586310
3Abnormality of nail color (HP:0100643)6.04057669
4Abnormal hair laboratory examination (HP:0003328)5.63983571
5Fragile nails (HP:0001808)5.56106596
6Absent eyebrow (HP:0002223)5.38133082
7Fine hair (HP:0002213)5.28838723
8Alopecia of scalp (HP:0002293)4.85591470
9Onycholysis (HP:0001806)4.82672329
10Palmoplantar hyperkeratosis (HP:0000972)4.77769013
11Absent hair (HP:0002298)4.71378854
12Increased IgE level (HP:0003212)4.63098826
13Palmar hyperkeratosis (HP:0010765)4.49857450
14Plantar hyperkeratosis (HP:0007556)4.39575735
15Thick nail (HP:0001805)4.38792867
16Abnormality of secondary sexual hair (HP:0009888)4.37338565
17Abnormality of the axillary hair (HP:0100134)4.37338565
18Follicular hyperkeratosis (HP:0007502)4.34031500
19Right ventricular cardiomyopathy (HP:0011663)4.13497037
20Erythema (HP:0010783)3.62965141
21Alveolar cell carcinoma (HP:0006519)3.56978816
22Sparse eyelashes (HP:0000653)3.47177807
23Oral leukoplakia (HP:0002745)3.30195727
24Milia (HP:0001056)3.30066625
25Neoplasm of the tracheobronchial system (HP:0100552)3.26369992
26Abnormality of the frontal sinuses (HP:0002687)3.07409338
27Amelogenesis imperfecta (HP:0000705)3.07050997
28Erythroderma (HP:0001019)2.92026765
29Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.86661522
30Parakeratosis (HP:0001036)2.78520777
31Curly hair (HP:0002212)2.68640852
32Hamartoma of the eye (HP:0010568)2.66972065
33Congenital, generalized hypertrichosis (HP:0004540)2.65772237
34Ridged nail (HP:0001807)2.63940327
35Congenital ichthyosiform erythroderma (HP:0007431)2.54107201
36Aplasia cutis congenita (HP:0001057)2.50630056
37Intention tremor (HP:0002080)2.47383176
38Neck muscle weakness (HP:0000467)2.43390206
39Abnormal blistering of the skin (HP:0008066)2.42934060
40Natal tooth (HP:0000695)2.42518806
41Muscle fiber inclusion bodies (HP:0100299)2.39257692
42Nemaline bodies (HP:0003798)2.32550990
43Advanced eruption of teeth (HP:0006288)2.32546457
44Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.29752631
45Dry hair (HP:0011359)2.28646982
46Exercise-induced myalgia (HP:0003738)2.21904360
47Torticollis (HP:0000473)2.21693416
48Neoplasm of the heart (HP:0100544)2.18626585
49Corneal erosion (HP:0200020)2.10350996
50Ankle clonus (HP:0011448)2.07106081
51Hypohidrosis (HP:0000966)2.06086948
52Palmoplantar keratoderma (HP:0000982)2.02250442
53Hypotrichosis (HP:0001006)14.8690197
54Slow-growing hair (HP:0002217)11.2113017
55Abnormality of hair growth rate (HP:0011363)11.2113017
56Woolly hair (HP:0002224)10.8394496
57Brittle hair (HP:0002299)10.5284734
58Ventricular tachycardia (HP:0004756)1.94917258
59Pruritus (HP:0000989)1.87869039
60Abnormality of the parietal bone (HP:0002696)1.86800985
61Craniofacial dystonia (HP:0012179)1.86792617
62Difficulty walking (HP:0002355)1.84284367
63Ventricular fibrillation (HP:0001663)1.77612039
64Abnormality of the pupil (HP:0000615)1.76597900
65Concave nail (HP:0001598)1.75666314
66Conjunctival hamartoma (HP:0100780)1.75243731
67Abnormality of the dental root (HP:0006486)1.74800468
68Taurodontia (HP:0000679)1.74800468
69Abnormality of permanent molar morphology (HP:0011071)1.74800468
70Abnormality of molar morphology (HP:0011070)1.72718853
71Abnormality of molar (HP:0011077)1.72718853
72Absent eyelashes (HP:0000561)1.71376007
73Abnormality of dental color (HP:0011073)1.71265920
74Focal dystonia (HP:0004373)1.70336258
75Hyporeflexia of lower limbs (HP:0002600)1.66173258
76Abnormality of the neuromuscular junction (HP:0003398)1.65995939
77Fatigable weakness (HP:0003473)1.65995939
78Widely patent fontanelles and sutures (HP:0004492)1.64501258
79Ependymoma (HP:0002888)1.60943518
80Generalized hypopigmentation of hair (HP:0011358)1.60728379
81Abnormality of the aortic arch (HP:0012303)1.59450670
82Abnormal delayed hypersensitivity skin test (HP:0002963)1.58353004
83Unilateral renal agenesis (HP:0000122)1.57914086
84Recurrent corneal erosions (HP:0000495)1.56074338
85Lymphangioma (HP:0100764)1.54001903
86Abnormality of the dental pulp (HP:0006479)1.52332618
87Blepharitis (HP:0000498)1.52027908
88Tracheomalacia (HP:0002779)1.49677470
89Sudden death (HP:0001699)1.49229807
90Coarse hair (HP:0002208)1.48844679
91Abnormality of placental membranes (HP:0011409)1.48667492
92Amniotic constriction ring (HP:0009775)1.48667492
93Exercise-induced muscle cramps (HP:0003710)1.47590489
94Acanthosis nigricans (HP:0000956)1.47096456
95Heterogeneous (HP:0001425)1.46696503
96Lip pit (HP:0100267)1.44225553
97Round ear (HP:0100830)1.39697678
98Gangrene (HP:0100758)1.39634108
99Distal lower limb muscle weakness (HP:0009053)1.39617804
100Type 1 muscle fiber predominance (HP:0003803)1.39293687
101Carious teeth (HP:0000670)1.37477435
102Ectropion (HP:0000656)1.37358177
103Keratoconjunctivitis sicca (HP:0001097)1.35395020
104Hypergammaglobulinemia (HP:0010702)1.33497449
105Achilles tendon contracture (HP:0001771)1.32313485
106Anonychia (HP:0001798)1.30948965
107Craniofacial hyperostosis (HP:0004493)1.30241385
108Atrophic scars (HP:0001075)1.29930816
109Furrowed tongue (HP:0000221)1.29384618
110Popliteal pterygium (HP:0009756)1.28342439
111Abnormality of the labia majora (HP:0012881)1.27235090
112Abnormality of the salivary glands (HP:0010286)1.26382336
113Increased connective tissue (HP:0009025)1.26083063
114Muscle hypertrophy of the lower extremities (HP:0008968)1.25652217
115Abnormality of the fingernails (HP:0001231)1.25445443
116Autoamputation (HP:0001218)1.25284378
117Muscle fiber splitting (HP:0003555)1.25103625
118Infantile muscular hypotonia (HP:0008947)1.24316557
119Neoplasm of the lung (HP:0100526)1.24262860
120Abnormality of the Achilles tendon (HP:0005109)1.23838091
121Hypoplastic labia majora (HP:0000059)1.23794605
122Visceral angiomatosis (HP:0100761)1.23189637
123Variable expressivity (HP:0003828)1.23065812
124Sparse scalp hair (HP:0002209)1.20783446
125Neonatal onset (HP:0003623)1.20619424
126Distal arthrogryposis (HP:0005684)1.19105610
127Keratoconjunctivitis (HP:0001096)1.18763514
128Selective tooth agenesis (HP:0001592)1.18701862
129Pulmonary infiltrates (HP:0002113)1.18405395
130Bronchomalacia (HP:0002780)1.18050448
131Laryngomalacia (HP:0001601)1.17377801
132Nasolacrimal duct obstruction (HP:0000579)1.16915316
133Abnormality of the calf musculature (HP:0001430)1.13893744
134Lack of skin elasticity (HP:0100679)1.13643456
135Multifactorial inheritance (HP:0001426)1.12854709
136Urticaria (HP:0001025)1.12640865
137Hamartoma (HP:0010566)1.12383148
138Widely spaced teeth (HP:0000687)1.12106270

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAF16.89467083
2STK245.80571963
3EPHA24.27939685
4FER3.98167359
5TAOK13.83209210
6MAPKAPK33.78827060
7ERN13.67071849
8MAP3K33.57825154
9MAP3K63.34609455
10EPHB23.13361595
11MAP3K112.76709316
12TRIB32.61467822
13CAMK1D2.41998090
14MAP3K22.28190912
15LATS12.18735649
16PIK3CG2.10578335
17RPS6KB21.99665250
18TTN1.88810376
19MAP2K31.81378239
20MAP2K61.76501617
21EPHB11.72159791
22EEF2K1.68038242
23NME11.64013902
24LATS21.57923190
25JAK31.44350187
26MAP3K11.42640069
27MARK11.38771463
28CAMK1G1.38645233
29EPHA41.35399795
30BCR1.31191115
31ITK1.28151308
32CAMK41.27487125
33CAMK11.27166149
34RIPK11.25189610
35FGFR21.24093714
36FGFR41.23060991
37SGK31.21024413
38FGFR11.19679199
39PINK11.14889536
40PKN21.11464309
41MST1R1.11042024
42TAOK21.08297362
43CDK61.07618634
44BMX1.06959892
45STK31.06959635
46MAPKAPK21.06567347
47MUSK0.99709769
48MAP3K70.98284304
49MATK0.97404886
50FGFR30.96749268
51LRRK20.95623093
52KSR20.95581945
53PTK60.95396738
54BLK0.93122795
55PBK0.90225228
56PRPF4B0.90134589
57RPS6KA20.88165937
58PDGFRA0.87443010
59PTK20.86314020
60TESK10.85431203
61SIK10.84928557
62PIM20.84737248
63MAPK70.84734126
64RPS6KA40.78124153
65MAPKAPK50.77754491
66STK390.77039418
67MAP2K10.74771549
68OBSCN0.74356753
69MAP3K90.73990854
70MAP3K50.71343904
71TEC0.71153507
72MAP2K40.67875791
73DYRK1B0.67344758
74TGFBR20.66421020
75PAK40.65208398
76SGK20.64944683
77PRKD10.63490898
78MAP3K100.62593819
79TRPM70.60728306
80STK380.59723797
81SGK2230.59177043
82SGK4940.59177043
83PAK30.58380260
84DDR20.58336696
85STK38L0.56935119
86ROCK20.54724693
87NEK10.53846668
88MET0.52388934
89EPHA30.52054728
90ERBB40.51760280
91MST40.51508334
92DAPK20.51103337
93PRKCI0.48907620
94PRKAA20.48852874
95LIMK10.48500924
96RPS6KC10.47666662
97RPS6KL10.47666662
98CDK190.47505744
99PRKCH0.47294436
100OXSR10.47019244
101PRKAA10.46820661
102ERBB20.45177331
103MAPK120.45146691
104MAPK40.45110119
105CCNB10.45084907
106GSK3A0.44497841
107CAMK2A0.43538387
108NTRK30.43310230
109CSK0.43222915
110CAMK2G0.43201240
111ERBB30.42380635
112PAK20.42325127
113PKN10.41502606
114PAK60.40503340
115RPS6KA60.40295340
116ROCK10.40088050
117RPS6KA10.40062478
118TGFBR10.39690170
119JAK10.39616487
120UHMK10.38521484
121ILK0.37369088
122NTRK20.37210075
123RPS6KB10.36928149
124IKBKB0.36325318
125TYRO30.35754981
126RET0.35655201
127MINK10.34952123
128MAP2K20.34677580
129ALK0.33407878
130CSNK1E0.33246759
131MAP3K80.32613770
132PHKG20.32528228
133PHKG10.32528228
134JAK20.30801213
135MOS0.30284162
136TYK20.30198416
137PRKCZ0.28639237
138MAPK130.28140833
139CASK0.25886306
140CAMK2B0.25511007
141FYN0.25301834
142MYLK0.25019575
143SGK10.22113018
144PDK20.21228335
145LMTK20.21084113
146CSNK1A10.20600633
147PRKACG0.20546448
148SRC0.20503210
149PRKACA0.20282824
150CDK50.20261551
151CLK10.20014033
152MAPK80.19663861
153PRKCG0.16780388

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.88133489
2Linoleic acid metabolism_Homo sapiens_hsa005914.83891540
3Fat digestion and absorption_Homo sapiens_hsa049753.15617239
4Vitamin digestion and absorption_Homo sapiens_hsa049772.81359409
5Fatty acid elongation_Homo sapiens_hsa000622.75834040
6Fatty acid biosynthesis_Homo sapiens_hsa000612.58477173
7Ether lipid metabolism_Homo sapiens_hsa005652.53410518
8Basal cell carcinoma_Homo sapiens_hsa052172.35428710
9Arachidonic acid metabolism_Homo sapiens_hsa005901.90382135
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.89750817
11Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.85699051
12Sulfur metabolism_Homo sapiens_hsa009201.83924239
13Fructose and mannose metabolism_Homo sapiens_hsa000511.83887090
14Phenylalanine metabolism_Homo sapiens_hsa003601.81083569
15VEGF signaling pathway_Homo sapiens_hsa043701.66193028
16Melanogenesis_Homo sapiens_hsa049161.61738440
17Axon guidance_Homo sapiens_hsa043601.53096861
18Bladder cancer_Homo sapiens_hsa052191.49183737
19Hedgehog signaling pathway_Homo sapiens_hsa043401.43846764
20Retinol metabolism_Homo sapiens_hsa008301.43035933
21Sphingolipid metabolism_Homo sapiens_hsa006001.42445156
22Histidine metabolism_Homo sapiens_hsa003401.36757322
23Proteoglycans in cancer_Homo sapiens_hsa052051.35147243
24Hippo signaling pathway_Homo sapiens_hsa043901.34972289
25GnRH signaling pathway_Homo sapiens_hsa049121.30781979
26Glioma_Homo sapiens_hsa052141.29466511
27Tight junction_Homo sapiens_hsa045301.27716817
28Vascular smooth muscle contraction_Homo sapiens_hsa042701.27196588
29Caffeine metabolism_Homo sapiens_hsa002321.25956719
30Thyroid cancer_Homo sapiens_hsa052161.24893207
31Adherens junction_Homo sapiens_hsa045201.17194436
32Acute myeloid leukemia_Homo sapiens_hsa052211.16730319
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.15927762
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15153678
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14829982
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.12981682
37Ovarian steroidogenesis_Homo sapiens_hsa049131.12903237
38ECM-receptor interaction_Homo sapiens_hsa045121.09970222
39Pancreatic secretion_Homo sapiens_hsa049721.07814366
40Amphetamine addiction_Homo sapiens_hsa050311.06387095
41Circadian entrainment_Homo sapiens_hsa047131.05806927
42Mineral absorption_Homo sapiens_hsa049781.01180408
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.01062261
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.00010048
45AMPK signaling pathway_Homo sapiens_hsa041520.98939739
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.98102505
47Dorso-ventral axis formation_Homo sapiens_hsa043200.97584128
48PPAR signaling pathway_Homo sapiens_hsa033200.97419749
49Leukocyte transendothelial migration_Homo sapiens_hsa046700.95329490
50Synaptic vesicle cycle_Homo sapiens_hsa047210.94628907
51Tyrosine metabolism_Homo sapiens_hsa003500.93958374
52Glycerolipid metabolism_Homo sapiens_hsa005610.93941951
53Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.93569471
54Long-term potentiation_Homo sapiens_hsa047200.93374436
55cAMP signaling pathway_Homo sapiens_hsa040240.93290301
56Calcium signaling pathway_Homo sapiens_hsa040200.93013512
57Steroid biosynthesis_Homo sapiens_hsa001000.92174592
58Pertussis_Homo sapiens_hsa051330.90250781
59Endometrial cancer_Homo sapiens_hsa052130.89469199
60Serotonergic synapse_Homo sapiens_hsa047260.88343093
61Glycerophospholipid metabolism_Homo sapiens_hsa005640.87686524
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85429976
63Amoebiasis_Homo sapiens_hsa051460.84634306
64Glucagon signaling pathway_Homo sapiens_hsa049220.83688967
65Wnt signaling pathway_Homo sapiens_hsa043100.83397002
66Non-small cell lung cancer_Homo sapiens_hsa052230.81359464
67Estrogen signaling pathway_Homo sapiens_hsa049150.81204810
68Nitrogen metabolism_Homo sapiens_hsa009100.80833940
69beta-Alanine metabolism_Homo sapiens_hsa004100.79591361
70Ras signaling pathway_Homo sapiens_hsa040140.79581983
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76462340
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75237551
73Long-term depression_Homo sapiens_hsa047300.73865982
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70224242
75Staphylococcus aureus infection_Homo sapiens_hsa051500.68648499
76Hepatitis C_Homo sapiens_hsa051600.68089777
77Glutamatergic synapse_Homo sapiens_hsa047240.66949115
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66177348
79Gastric acid secretion_Homo sapiens_hsa049710.65077714
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63882244
81Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63409230
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.63282714
83Renin secretion_Homo sapiens_hsa049240.62721423
84Protein digestion and absorption_Homo sapiens_hsa049740.62379319
85Glycosaminoglycan degradation_Homo sapiens_hsa005310.61817985
86Phototransduction_Homo sapiens_hsa047440.61618330
87MicroRNAs in cancer_Homo sapiens_hsa052060.61508795
88Rap1 signaling pathway_Homo sapiens_hsa040150.59556124
89Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59193710
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.59045980
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.57881305
92Focal adhesion_Homo sapiens_hsa045100.57755278
93Insulin resistance_Homo sapiens_hsa049310.57470730
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57263028
95Arginine biosynthesis_Homo sapiens_hsa002200.56313553
96Salmonella infection_Homo sapiens_hsa051320.56255005
97Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55406301
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.54929257
99Nicotine addiction_Homo sapiens_hsa050330.54031437
100Cardiac muscle contraction_Homo sapiens_hsa042600.53137863
101Fatty acid metabolism_Homo sapiens_hsa012120.52414549
102Arginine and proline metabolism_Homo sapiens_hsa003300.51566461
103Salivary secretion_Homo sapiens_hsa049700.51520458
104mTOR signaling pathway_Homo sapiens_hsa041500.50363756
105ErbB signaling pathway_Homo sapiens_hsa040120.50356367
106Platelet activation_Homo sapiens_hsa046110.49978540
107Gap junction_Homo sapiens_hsa045400.49754848
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49284384
109TGF-beta signaling pathway_Homo sapiens_hsa043500.48044250
110Oxytocin signaling pathway_Homo sapiens_hsa049210.47808645
111Toxoplasmosis_Homo sapiens_hsa051450.47726218
112Butanoate metabolism_Homo sapiens_hsa006500.47697249
113Dopaminergic synapse_Homo sapiens_hsa047280.47081053
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.46470929
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.45862639
116Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45389583
117Renal cell carcinoma_Homo sapiens_hsa052110.44286512
118Chemical carcinogenesis_Homo sapiens_hsa052040.44185111
119Circadian rhythm_Homo sapiens_hsa047100.44105224
120Regulation of autophagy_Homo sapiens_hsa041400.42991621
121Collecting duct acid secretion_Homo sapiens_hsa049660.42780603
122Notch signaling pathway_Homo sapiens_hsa043300.42001635
123Fatty acid degradation_Homo sapiens_hsa000710.41284979
124Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41002132
125Chronic myeloid leukemia_Homo sapiens_hsa052200.40739928
126Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39834983
127Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39332262
128Tuberculosis_Homo sapiens_hsa051520.38758000
129Taste transduction_Homo sapiens_hsa047420.38205917
130Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37573826
131Prolactin signaling pathway_Homo sapiens_hsa049170.37279640
132Choline metabolism in cancer_Homo sapiens_hsa052310.36936758
133Insulin secretion_Homo sapiens_hsa049110.36563169
134Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36336655
135Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.36058041
136Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35972456
137Insulin signaling pathway_Homo sapiens_hsa049100.35514223
138Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.34787943
139MAPK signaling pathway_Homo sapiens_hsa040100.34207999
140Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34013415
141Dilated cardiomyopathy_Homo sapiens_hsa054140.33883690
142Pyruvate metabolism_Homo sapiens_hsa006200.33805815
143Adipocytokine signaling pathway_Homo sapiens_hsa049200.33339344
144Pathways in cancer_Homo sapiens_hsa052000.33219125
145p53 signaling pathway_Homo sapiens_hsa041150.33167692
146Olfactory transduction_Homo sapiens_hsa047400.32911530
147Starch and sucrose metabolism_Homo sapiens_hsa005000.32798089
148GABAergic synapse_Homo sapiens_hsa047270.31588461

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