KRT28

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1citrulline biosynthetic process (GO:0019240)9.04379648
2hair follicle morphogenesis (GO:0031069)8.59610054
3adhesion of symbiont to host (GO:0044406)8.45169732
4peptide cross-linking (GO:0018149)8.18774288
5intermediate filament cytoskeleton organization (GO:0045104)6.72646426
6intermediate filament-based process (GO:0045103)6.51907732
7epidermis development (GO:0008544)6.16000744
8cell wall macromolecule metabolic process (GO:0044036)6.01472199
9cell wall macromolecule catabolic process (GO:0016998)6.01472199
10citrulline metabolic process (GO:0000052)5.96309443
11hair cycle process (GO:0022405)5.64652073
12molting cycle process (GO:0022404)5.64652073
13keratinocyte differentiation (GO:0030216)5.58717121
14peptidyl-arginine modification (GO:0018195)5.10060827
15bundle of His cell to Purkinje myocyte communication (GO:0086069)5.03676052
16establishment of skin barrier (GO:0061436)4.80384495
17hemidesmosome assembly (GO:0031581)4.77521840
18skin morphogenesis (GO:0043589)4.61547936
19epidermal cell differentiation (GO:0009913)4.42850698
20regulation of water loss via skin (GO:0033561)4.32487459
21tooth mineralization (GO:0034505)4.05461282
22keratinocyte development (GO:0003334)4.04317026
23molting cycle (GO:0042303)35.3722642
24hair cycle (GO:0042633)35.3722642
25positive regulation of hair cycle (GO:0042635)3.56227919
26positive regulation of hair follicle development (GO:0051798)3.56227919
27hair follicle development (GO:0001942)3.45901492
28negative regulation of keratinocyte proliferation (GO:0010839)3.42747623
29regulation of hair follicle development (GO:0051797)3.36493773
30regulation of keratinocyte differentiation (GO:0045616)3.34192448
31phosphatidylinositol acyl-chain remodeling (GO:0036149)3.31176775
32negative regulation of establishment of protein localization to plasma membrane (GO:0090005)3.25065127
33bone trabecula formation (GO:0060346)3.17724794
34phosphatidylserine acyl-chain remodeling (GO:0036150)3.06726698
35epithelium development (GO:0060429)2.92880746
36multicellular organismal water homeostasis (GO:0050891)2.91746302
37positive regulation of meiotic cell cycle (GO:0051446)2.90949076
38regulation of hair cycle (GO:0042634)2.90561619
39positive regulation of epidermis development (GO:0045684)2.88871648
40phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.79798962
41gap junction assembly (GO:0016264)2.74711558
42atrioventricular valve morphogenesis (GO:0003181)2.73731219
43ectoderm development (GO:0007398)2.73221194
44epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.68447210
45negative regulation of protein localization to plasma membrane (GO:1903077)2.65636119
46regulation of epidermal cell differentiation (GO:0045604)2.61391296
47regulation of epidermis development (GO:0045682)2.57917550
48cranial suture morphogenesis (GO:0060363)2.45536569
49ventricular cardiac muscle cell action potential (GO:0086005)2.44450475
50wound healing, spreading of epidermal cells (GO:0035313)2.44187082
51regulation of mesenchymal cell apoptotic process (GO:2001053)2.37832429
52cell surface receptor signaling pathway involved in heart development (GO:0061311)2.37680534
53water homeostasis (GO:0030104)2.36899943
54phosphatidylserine metabolic process (GO:0006658)2.35061618
55positive regulation of epidermal cell differentiation (GO:0045606)2.31385461
56fatty acid elongation (GO:0030497)2.30299929
57negative regulation of cell fate specification (GO:0009996)2.30166561
58negative regulation of epidermis development (GO:0045683)2.24284311
59phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.23459574
60outflow tract septum morphogenesis (GO:0003148)2.16712202
61regulation of cardioblast differentiation (GO:0051890)2.12372009
62planar cell polarity pathway involved in neural tube closure (GO:0090179)2.11517824
63lymph vessel development (GO:0001945)2.11214474
64skin development (GO:0043588)2.09379852
65aging (GO:0007568)2.03923585
66regulation of keratinocyte proliferation (GO:0010837)2.02097172
67intermediate filament organization (GO:0045109)12.3772712
68keratinization (GO:0031424)10.4664913
69desmosome organization (GO:0002934)10.0714784
70adhesion of symbiont to host cell (GO:0044650)10.0266717
71virion attachment to host cell (GO:0019062)10.0266717
72epithelial cell-cell adhesion (GO:0090136)1.98248483
73myotube differentiation (GO:0014902)1.96854990
74positive regulation of monocyte chemotaxis (GO:0090026)1.96232307
75phosphatidylcholine acyl-chain remodeling (GO:0036151)1.95491885
76regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)1.94801465
77regulation of heart rate by cardiac conduction (GO:0086091)1.94388187
78non-canonical Wnt signaling pathway (GO:0035567)1.90557942
79regulation of Wnt signaling pathway involved in heart development (GO:0003307)1.86997808
80cytoskeletal anchoring at plasma membrane (GO:0007016)1.86920002
81ephrin receptor signaling pathway (GO:0048013)1.84327822
82regulation of ruffle assembly (GO:1900027)1.84290277
83regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901211.81529583
84cell communication involved in cardiac conduction (GO:0086065)1.79402202
85regulation of transforming growth factor beta2 production (GO:0032909)1.78682754
86alditol phosphate metabolic process (GO:0052646)1.77934139
87negative regulation of epidermal cell differentiation (GO:0045605)1.77598269
88G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071991.76914075
89lateral sprouting from an epithelium (GO:0060601)1.75377785
90cell-substrate junction assembly (GO:0007044)1.74830162
91craniofacial suture morphogenesis (GO:0097094)1.74758417
92eyelid development in camera-type eye (GO:0061029)1.74352097
93coronary vasculature morphogenesis (GO:0060977)1.71667175
94wound healing, spreading of cells (GO:0044319)1.71601353
95negative regulation of Ras GTPase activity (GO:0034261)1.71237174
96lung-associated mesenchyme development (GO:0060484)1.70852305
97establishment of planar polarity (GO:0001736)1.70364732
98establishment of tissue polarity (GO:0007164)1.70364732
99cardiac right ventricle morphogenesis (GO:0003215)1.64152356
100regulation of cardioblast proliferation (GO:0003264)1.61106505

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.60288257
2CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human5.15375673
3P63_26484246_Chip-Seq_KERATINOCYTES_Human3.57702228
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.71654730
5CTCF_20526341_ChIP-Seq_ESCs_Human2.37389554
6NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse2.25018892
7BMI1_19503595_ChIP-Seq_MEFsC_Mouse2.21812186
8TP63_17297297_ChIP-ChIP_HaCaT_Human12.9068586
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.93882041
10TAF2_19829295_ChIP-Seq_ESCs_Human1.83966062
11VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.74581842
12* E2F1_20622854_ChIP-Seq_HELA_Human1.74227099
13NANOG_20526341_ChIP-Seq_ESCs_Human1.74017058
14EGR1_19032775_ChIP-ChIP_M12_Human1.73756921
15CSB_26484114_Chip-Seq_FIBROBLAST_Human1.73706601
16P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.72580375
17SOX9_24532713_ChIP-Seq_HFSC_Mouse1.68489318
18CTCF_27219007_Chip-Seq_Bcells_Human1.64908679
19P53_21459846_ChIP-Seq_SAOS-2_Human1.61688717
20TP53_20018659_ChIP-ChIP_R1E_Mouse1.58223877
21RACK7_27058665_Chip-Seq_MCF-7_Human1.57544231
22ERG_20517297_ChIP-Seq_VCAP_Human1.57434946
23MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.54345935
24FOXO3_23340844_ChIP-Seq_DLD1_Human1.53379083
25BCL6_27268052_Chip-Seq_Bcells_Human1.51430585
26TP63_22573176_ChIP-Seq_HFKS_Human1.51276520
27YY1_22570637_ChIP-Seq_MALME-3M_Human1.48980644
28SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.48717890
29SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.48717890
30LXR_22292898_ChIP-Seq_THP-1_Human1.48534404
31UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.44551668
32BCOR_27268052_Chip-Seq_Bcells_Human1.43887822
33ATF3_27146783_Chip-Seq_COLON_Human1.40325054
34ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.38630358
35ESR1_21235772_ChIP-Seq_MCF-7_Human1.36614285
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.36228542
37PHF8_20622854_ChIP-Seq_HELA_Human1.32629925
38RARG_19884340_ChIP-ChIP_MEFs_Mouse1.32528429
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.31700587
40P68_20966046_ChIP-Seq_HELA_Human1.27046474
41SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.26819943
42KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25973773
43AHR_22903824_ChIP-Seq_MCF-7_Human1.25811383
44ARNT_22903824_ChIP-Seq_MCF-7_Human1.25568040
45SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.22611322
46ELF1_20517297_ChIP-Seq_JURKAT_Human1.20813944
47KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20195699
48E2F1_17053090_ChIP-ChIP_MCF-7_Human1.17993648
49SUZ12_27294783_Chip-Seq_ESCs_Mouse1.17113133
50* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14737772
51SMC4_20622854_ChIP-Seq_HELA_Human1.14176436
52UBF1/2_26484160_Chip-Seq_HMECs_Human1.14080560
53RAC3_21632823_ChIP-Seq_H3396_Human1.13901377
54CEBPB_22108803_ChIP-Seq_LS180_Human1.13770334
55ELK4_26923725_Chip-Seq_MESODERM_Mouse1.12655241
56P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10894494
57GATA3_24758297_ChIP-Seq_MCF-7_Human1.07717737
58TRIM28_21343339_ChIP-Seq_HEK293_Human1.06750604
59GATA4_25053715_ChIP-Seq_YYC3_Human1.06607751
60SA1_27219007_Chip-Seq_ERYTHROID_Human1.06467075
61IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05766653
62JARID2_20075857_ChIP-Seq_MESCs_Mouse1.04056734
63TP63_23658742_ChIP-Seq_EP156T_Human1.03840948
64RXRA_24833708_ChIP-Seq_LIVER_Mouse1.01458543
65PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.00824710
66CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00467498
67KLF5_25053715_ChIP-Seq_YYC3_Human0.99988833
68TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99927565
69ERG_21242973_ChIP-ChIP_JURKAT_Human0.99794798
70SPI1_20517297_ChIP-Seq_HL60_Human0.98890918
71EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98812168
72* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94845856
73RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.94539389
74GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.94028402
75ZNF263_19887448_ChIP-Seq_K562_Human0.93236710
76SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92946798
77RUNX1_27514584_Chip-Seq_MCF-7_Human0.90690146
78TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89974692
79* SOX2_21211035_ChIP-Seq_LN229_Human0.89558587
80* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89369165
81RING1B_27294783_Chip-Seq_ESCs_Mouse0.87407971
82RXR_22108803_ChIP-Seq_LS180_Human0.86990817
83TP53_18474530_ChIP-ChIP_U2OS_Human0.85968535
84RNF2_27304074_Chip-Seq_ESCs_Mouse0.85391806
85GATA6_21074721_ChIP-Seq_CACO-2_Human0.84537855
86NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.83043855
87ELK3_25401928_ChIP-Seq_HUVEC_Human0.82103678
88ZFP281_18757296_ChIP-ChIP_E14_Mouse0.81301341
89GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.81180675
90* FOXH1_21741376_ChIP-Seq_ESCs_Human0.80359193
91TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.79855818
92KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.78949027
93SOX2_20726797_ChIP-Seq_SW620_Human0.76897032
94EZH2_27294783_Chip-Seq_ESCs_Mouse0.76279623
95CDX2_19796622_ChIP-Seq_MESCs_Mouse0.76073809
96FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.73346080
97BMI1_23680149_ChIP-Seq_NPCS_Mouse0.72710151
98JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.68737473
99AR_21572438_ChIP-Seq_LNCaP_Human0.68690948
100GATA6_25053715_ChIP-Seq_YYC3_Human0.68152699

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology7.85214821
2MP0002098_abnormal_vibrissa_morphology7.40708532
3MP0000647_abnormal_sebaceous_gland6.57920838
4MP0002796_impaired_skin_barrier5.42165408
5MP0010234_abnormal_vibrissa_follicle5.00557804
6MP0005275_abnormal_skin_tensile4.87888481
7MP0000383_abnormal_hair_follicle4.84344205
8MP0010678_abnormal_skin_adnexa4.25032871
9MP0000377_abnormal_hair_follicle4.19345384
10MP0000427_abnormal_hair_cycle3.65136137
11MP0003705_abnormal_hypodermis_morpholog3.64975584
12MP0005501_abnormal_skin_physiology3.40052349
13MP0002254_reproductive_system_inflammat3.00504324
14MP0001216_abnormal_epidermal_layer2.60591780
15MP0004381_abnormal_hair_follicle2.54778509
16MP0000367_abnormal_coat/_hair2.39867293
17MP0001243_abnormal_dermal_layer2.29811446
18MP0010771_integument_phenotype2.20037235
19MP0004947_skin_inflammation2.13313438
20MP0003453_abnormal_keratinocyte_physiol2.12408781
21MP0002060_abnormal_skin_morphology2.08333022
22MP0002234_abnormal_pharynx_morphology2.01147621
23MP0000467_abnormal_esophagus_morphology1.66498084
24MP0009053_abnormal_anal_canal1.60540186
25MP0000762_abnormal_tongue_morphology1.51793523
26MP0009931_abnormal_skin_appearance1.44521373
27MP0005409_darkened_coat_color1.44071068
28MP0003566_abnormal_cell_adhesion1.35408281
29MP0003941_abnormal_skin_development1.08084112
30MP0004885_abnormal_endolymph0.97440325
31MP0001191_abnormal_skin_condition0.94826665
32MP0001661_extended_life_span0.88732133
33MP0004185_abnormal_adipocyte_glucose0.86047526
34MP0004264_abnormal_extraembryonic_tissu0.82559919
35MP0002095_abnormal_skin_pigmentation0.82023788
36MP0001851_eye_inflammation0.77389894
37MP0010030_abnormal_orbit_morphology0.74548218
38MP0003315_abnormal_perineum_morphology0.73990149
39MP0000566_synostosis0.71981493
40MP0001340_abnormal_eyelid_morphology0.69805900
41MP0001346_abnormal_lacrimal_gland0.69574646
42MP0008438_abnormal_cutaneous_collagen0.68588764
43MP0001849_ear_inflammation0.65378733
44MP0002877_abnormal_melanocyte_morpholog0.63703589
45MP0000627_abnormal_mammary_gland0.60600294
46MP0003755_abnormal_palate_morphology0.56036792
47MP0002282_abnormal_trachea_morphology0.51291143
48MP0002970_abnormal_white_adipose0.47558704
49MP0002249_abnormal_larynx_morphology0.44820843
50MP0002111_abnormal_tail_morphology0.43568682
51MP0005451_abnormal_body_composition0.42566076
52MP0001784_abnormal_fluid_regulation0.42450820
53MP0000537_abnormal_urethra_morphology0.42420410
54MP0005023_abnormal_wound_healing0.41324227
55MP0005075_abnormal_melanosome_morpholog0.40170621
56MP0009840_abnormal_foam_cell0.38471105
57MP0003191_abnormal_cellular_cholesterol0.38426481
58MP0003385_abnormal_body_wall0.34888180
59MP0004272_abnormal_basement_membrane0.32315456
60MP0010352_gastrointestinal_tract_polyps0.31312514
61MP0000678_abnormal_parathyroid_gland0.31104591
62MP0003950_abnormal_plasma_membrane0.28274258
63MP0005248_abnormal_Harderian_gland0.26812141
64MP0002697_abnormal_eye_size0.26660558
65MP0000432_abnormal_head_morphology0.24629577
66MP0002177_abnormal_outer_ear0.24612694
67MP0003935_abnormal_craniofacial_develop0.21921822
68MP0000465_gastrointestinal_hemorrhage0.20417574
69MP0003763_abnormal_thymus_physiology0.20042803
70MP0004742_abnormal_vestibular_system0.19627840
71MP0000462_abnormal_digestive_system0.19211275
72MP0006054_spinal_hemorrhage0.17999899
73MP0003329_amyloid_beta_deposits0.17497120
74MP0000516_abnormal_urinary_system0.16280746
75MP0005367_renal/urinary_system_phenotyp0.16280746
76MP0004858_abnormal_nervous_system0.16206442
77MP0002233_abnormal_nose_morphology0.16006998
78MP0004019_abnormal_vitamin_homeostasis0.15663095
79MP0001879_abnormal_lymphatic_vessel0.15348876
80MP0001730_embryonic_growth_arrest0.13968041
81MP0005666_abnormal_adipose_tissue0.13552772
82MP0005375_adipose_tissue_phenotype0.13540591
83MP0005076_abnormal_cell_differentiation0.13162723
84MP0000428_abnormal_craniofacial_morphol0.12253331
85MP0000733_abnormal_muscle_development0.12211030
86MP0000013_abnormal_adipose_tissue0.11274545
87MP0003300_gastrointestinal_ulcer0.10973145
88MP0009384_cardiac_valve_regurgitation0.10531281
89MP0003448_altered_tumor_morphology0.10362265
90MP0005193_abnormal_anterior_eye0.10016052
91MP0003937_abnormal_limbs/digits/tail_de0.09910977
92MP0006138_congestive_heart_failure0.09592368
93MP0005508_abnormal_skeleton_morphology0.09516845
94MP0002006_tumorigenesis0.08603643
95MP0003638_abnormal_response/metabolism_0.08203752
96MP0000750_abnormal_muscle_regeneration0.08052407
97MP0002166_altered_tumor_susceptibility0.07945361
98MP0000751_myopathy0.07885608
99MP0002009_preneoplasia0.05578022
100MP0002896_abnormal_bone_mineralization0.04834823

Predicted human phenotypes

RankGene SetZ-score
1Pili torti (HP:0003777)9.40052556
2Nail dystrophy (HP:0008404)7.39677996
3Abnormal hair laboratory examination (HP:0003328)5.90407632
4Abnormality of nail color (HP:0100643)5.76415833
5Fragile nails (HP:0001808)5.66249044
6Fine hair (HP:0002213)5.38884211
7Alopecia of scalp (HP:0002293)4.73740993
8Follicular hyperkeratosis (HP:0007502)4.54808565
9Onycholysis (HP:0001806)4.46119325
10Palmoplantar hyperkeratosis (HP:0000972)4.45443830
11Thick nail (HP:0001805)4.27749269
12Palmar hyperkeratosis (HP:0010765)4.19037694
13Plantar hyperkeratosis (HP:0007556)4.10468724
14Right ventricular cardiomyopathy (HP:0011663)3.99744633
15Increased IgE level (HP:0003212)3.77340301
16Sparse eyelashes (HP:0000653)3.71690119
17Milia (HP:0001056)3.51792632
18Amelogenesis imperfecta (HP:0000705)3.21549624
19Abnormality of the frontal sinuses (HP:0002687)3.21110450
20Oral leukoplakia (HP:0002745)3.19917657
21Erythema (HP:0010783)3.19408566
22Congenital, generalized hypertrichosis (HP:0004540)2.96840848
23Parakeratosis (HP:0001036)2.94111234
24Curly hair (HP:0002212)2.71386934
25Ridged nail (HP:0001807)2.66204594
26Intention tremor (HP:0002080)2.58398774
27Aplasia cutis congenita (HP:0001057)2.58359112
28Erythroderma (HP:0001019)2.54368299
29Neck muscle weakness (HP:0000467)2.51410697
30Natal tooth (HP:0000695)2.47960446
31Torticollis (HP:0000473)2.40940237
32Dry hair (HP:0011359)2.40031452
33Advanced eruption of teeth (HP:0006288)2.32065925
34Abnormality of the parietal bone (HP:0002696)2.30338509
35Abnormal blistering of the skin (HP:0008066)2.19600097
36Congenital ichthyosiform erythroderma (HP:0007431)2.19047007
37Craniofacial dystonia (HP:0012179)2.01936798
38Hypotrichosis (HP:0001006)14.7583793
39Slow-growing hair (HP:0002217)11.3774610
40Abnormality of hair growth rate (HP:0011363)11.3774610
41Woolly hair (HP:0002224)11.2467615
42Brittle hair (HP:0002299)10.5728018
43Corneal erosion (HP:0200020)1.97024001
44Hypohidrosis (HP:0000966)1.95649758
45Absent eyelashes (HP:0000561)1.93461862
46Ventricular tachycardia (HP:0004756)1.90318930
47Concave nail (HP:0001598)1.89079378
48Abnormality of the dental root (HP:0006486)1.88817864
49Taurodontia (HP:0000679)1.88817864
50Abnormality of permanent molar morphology (HP:0011071)1.88817864
51Difficulty walking (HP:0002355)1.86243732
52Abnormality of dental color (HP:0011073)1.85275727
53Focal dystonia (HP:0004373)1.84692523
54Abnormality of molar morphology (HP:0011070)1.84042851
55Abnormality of molar (HP:0011077)1.84042851
56Palmoplantar keratoderma (HP:0000982)1.82607824
57Ventricular fibrillation (HP:0001663)1.82014042
58Abnormality of the pupil (HP:0000615)1.78208544
59Pruritus (HP:0000989)1.77892846
60Widely patent fontanelles and sutures (HP:0004492)1.71924220
61Abnormality of the dental pulp (HP:0006479)1.64331475
62Blepharitis (HP:0000498)1.64284999
63Abnormality of the aortic arch (HP:0012303)1.63679136
64Recurrent corneal erosions (HP:0000495)1.57174659
65Fatigable weakness (HP:0003473)1.54867822
66Abnormality of the neuromuscular junction (HP:0003398)1.54867822
67Unilateral renal agenesis (HP:0000122)1.50843055
68Hyporeflexia of lower limbs (HP:0002600)1.48402401
69Abnormality of placental membranes (HP:0011409)1.47431950
70Amniotic constriction ring (HP:0009775)1.47431950
71Heterogeneous (HP:0001425)1.45462247
72Acanthosis nigricans (HP:0000956)1.44826013
73Lip pit (HP:0100267)1.42066605
74Carious teeth (HP:0000670)1.40018810
75Selective tooth agenesis (HP:0001592)1.39566136
76Sudden death (HP:0001699)1.38138808
77Craniofacial hyperostosis (HP:0004493)1.37208723
78Atrophic scars (HP:0001075)1.36223854
79Achilles tendon contracture (HP:0001771)1.35953812
80Anonychia (HP:0001798)1.33325581
81Sparse scalp hair (HP:0002209)1.29508073
82Abnormality of the fingernails (HP:0001231)1.27067729
83Abnormality of the Achilles tendon (HP:0005109)1.26697829
84Distal lower limb muscle weakness (HP:0009053)1.25628542
85Keratoconjunctivitis sicca (HP:0001097)1.24882025
86Type 1 muscle fiber predominance (HP:0003803)1.23603447
87Down-sloping shoulders (HP:0200021)1.23440446
88Autoamputation (HP:0001218)1.23128042
89Widely spaced teeth (HP:0000687)1.23063517
90Variable expressivity (HP:0003828)1.22608965
91Increased connective tissue (HP:0009025)1.22207280
92Round ear (HP:0100830)1.19621378
93Ectropion (HP:0000656)1.15587570
94Neonatal onset (HP:0003623)1.13661504
95Bronchomalacia (HP:0002780)1.11911595
96Laryngomalacia (HP:0001601)1.10501505
97Premature rupture of membranes (HP:0001788)1.09322542
98Keratoconjunctivitis (HP:0001096)1.08752659
99Wide cranial sutures (HP:0010537)1.06385149
100Fragile skin (HP:0001030)1.05686279

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.66216426
2FER4.10129796
3MAPKAPK33.89627671
4MAP3K63.79571383
5ERN13.64732451
6EPHB23.55030338
7TAOK13.23943855
8MAP3K32.97652247
9LATS12.81374027
10TRIB32.69800309
11MAP3K22.41285040
12LATS22.10725632
13MAP3K112.01540736
14RPS6KB21.88404432
15PIK3CG1.77568822
16EEF2K1.75640158
17BCR1.68763730
18EPHB11.64417071
19FGFR21.62190913
20NME11.57827213
21MAP2K61.57505487
22TTN1.53252485
23FGFR41.30733479
24MAP3K11.24198781
25RIPK11.23569288
26CDK61.21733723
27BMX1.19346328
28KSR21.17411073
29MAP2K31.13272474
30MAPKAPK21.06189018
31FGFR31.02586286
32RPS6KA41.01389880
33MAP3K70.98665235
34FGFR10.97860985
35PKN20.97611860
36PTK60.95599357
37PDGFRA0.92808031
38SIK10.91639536
39MST1R0.90123106
40PRKCI0.89996358
41STK38L0.88591457
42STK380.87167930
43MAP3K100.85750327
44BLK0.85150334
45PIM20.83177967
46LRRK20.82604145
47PBK0.82524903
48PAK40.78396781
49DYRK1B0.78059542
50MAP3K90.77660468
51PTK20.77277864
52MAP2K10.74509507
53PRKD10.70186772
54MAP2K40.68921693
55CDK190.63622613
56DDR20.60982539
57NEK10.60174593
58TYRO30.55232729
59PAK30.54187484
60PRKCH0.53355227
61ALK0.53174038
62CSNK1E0.53082085
63MET0.51686278
64ERBB20.51553875
65ERBB40.50938297
66MAP3K50.50279996
67RPS6KA10.49813634
68LIMK10.47417020
69MAPK120.46629337
70PAK20.46354509
71GSK3A0.46185953
72MAP2K20.46099569
73OBSCN0.45644187
74TESK10.44334219
75PAK60.41537719
76STK30.40055128
77TRPM70.39695035
78CLK10.37707676
79NTRK20.37470644
80JAK10.37168636
81CSNK1G10.37153880
82TYK20.35738930
83MTOR0.34891609
84MAP3K80.34138915
85CSNK1G30.33271877
86CSNK1A1L0.32023008
87RET0.29862209
88CSNK1A10.29343086
89STK110.28905032
90TGFBR10.28081000
91MAPK80.27112097
92CSNK1D0.25734263
93JAK20.25564186
94PRKACA0.25362255
95MST40.25157805
96PHKG10.24592619
97PHKG20.24592619
98MARK30.24216727
99NLK0.24058263
100ERBB30.23401162

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005925.05163617
2Linoleic acid metabolism_Homo sapiens_hsa005915.05101469
3Fat digestion and absorption_Homo sapiens_hsa049753.20832568
4Basal cell carcinoma_Homo sapiens_hsa052173.15077614
5Ether lipid metabolism_Homo sapiens_hsa005652.67702056
6Fatty acid elongation_Homo sapiens_hsa000622.63998453
7Hedgehog signaling pathway_Homo sapiens_hsa043402.20913642
8Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.87703256
9Arachidonic acid metabolism_Homo sapiens_hsa005901.85342032
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.82211575
11Melanogenesis_Homo sapiens_hsa049161.81022154
12VEGF signaling pathway_Homo sapiens_hsa043701.71748250
13Axon guidance_Homo sapiens_hsa043601.66175602
14Hippo signaling pathway_Homo sapiens_hsa043901.64739756
15Phenylalanine metabolism_Homo sapiens_hsa003601.62669326
16Thyroid cancer_Homo sapiens_hsa052161.62597845
17Bladder cancer_Homo sapiens_hsa052191.48513328
18Proteoglycans in cancer_Homo sapiens_hsa052051.41420472
19Glioma_Homo sapiens_hsa052141.39473313
20Acute myeloid leukemia_Homo sapiens_hsa052211.30197823
21Caffeine metabolism_Homo sapiens_hsa002321.29081665
22Dorso-ventral axis formation_Homo sapiens_hsa043201.28262028
23Histidine metabolism_Homo sapiens_hsa003401.26604109
24Vascular smooth muscle contraction_Homo sapiens_hsa042701.25606405
25Tight junction_Homo sapiens_hsa045301.24951295
26Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.22672519
27Mineral absorption_Homo sapiens_hsa049781.21586166
28Glycerophospholipid metabolism_Homo sapiens_hsa005641.14789300
29GnRH signaling pathway_Homo sapiens_hsa049121.12459749
30Endometrial cancer_Homo sapiens_hsa052131.09236215
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.08669170
32Steroid biosynthesis_Homo sapiens_hsa001001.05238624
33Pancreatic secretion_Homo sapiens_hsa049721.04461443
34ECM-receptor interaction_Homo sapiens_hsa045121.02926310
35Adherens junction_Homo sapiens_hsa045201.02863413
36Wnt signaling pathway_Homo sapiens_hsa043101.02424807
37Non-small cell lung cancer_Homo sapiens_hsa052231.02178032
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96324642
39Long-term potentiation_Homo sapiens_hsa047200.95741960
40PPAR signaling pathway_Homo sapiens_hsa033200.91986992
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.91774403
42Long-term depression_Homo sapiens_hsa047300.82206445
43Ras signaling pathway_Homo sapiens_hsa040140.81965426
44Tyrosine metabolism_Homo sapiens_hsa003500.79870191
45Estrogen signaling pathway_Homo sapiens_hsa049150.78491509
46Amoebiasis_Homo sapiens_hsa051460.78370119
47Nitrogen metabolism_Homo sapiens_hsa009100.75775982
48MicroRNAs in cancer_Homo sapiens_hsa052060.74363312
49Leukocyte transendothelial migration_Homo sapiens_hsa046700.70205576
50beta-Alanine metabolism_Homo sapiens_hsa004100.69573420
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.69233027
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68610321
53Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.68424688
54Protein digestion and absorption_Homo sapiens_hsa049740.67493580
55Pertussis_Homo sapiens_hsa051330.65890262
56Renal cell carcinoma_Homo sapiens_hsa052110.64192310
57Sphingolipid signaling pathway_Homo sapiens_hsa040710.61470761
58p53 signaling pathway_Homo sapiens_hsa041150.61312041
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59180214
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59003159
61Hepatitis C_Homo sapiens_hsa051600.58898477
62Insulin resistance_Homo sapiens_hsa049310.57794196
63TGF-beta signaling pathway_Homo sapiens_hsa043500.56032861
64Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.55591852
65Gap junction_Homo sapiens_hsa045400.55169384
66Notch signaling pathway_Homo sapiens_hsa043300.53642443
67Butanoate metabolism_Homo sapiens_hsa006500.53259870
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.52996746
69ErbB signaling pathway_Homo sapiens_hsa040120.52883377
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.51164813
71Focal adhesion_Homo sapiens_hsa045100.50867585
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50504329
73Rap1 signaling pathway_Homo sapiens_hsa040150.50408169
74Gastric acid secretion_Homo sapiens_hsa049710.49582447
75Pathways in cancer_Homo sapiens_hsa052000.45416588
76Fatty acid metabolism_Homo sapiens_hsa012120.44246143
77Melanoma_Homo sapiens_hsa052180.43948356
78Phototransduction_Homo sapiens_hsa047440.43661595
79Chronic myeloid leukemia_Homo sapiens_hsa052200.43521949
80Salmonella infection_Homo sapiens_hsa051320.42598698
81Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41723621
82Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.40040358
83Renin secretion_Homo sapiens_hsa049240.39756596
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39744816
85Oxytocin signaling pathway_Homo sapiens_hsa049210.38617805
86Prolactin signaling pathway_Homo sapiens_hsa049170.38401349
87Prion diseases_Homo sapiens_hsa050200.38138412
88Prostate cancer_Homo sapiens_hsa052150.37486831
89Staphylococcus aureus infection_Homo sapiens_hsa051500.37400046
90Insulin signaling pathway_Homo sapiens_hsa049100.35479760
91Platelet activation_Homo sapiens_hsa046110.35211694
92HTLV-I infection_Homo sapiens_hsa051660.33431657
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.31887466
94Endocytosis_Homo sapiens_hsa041440.30929233
95Salivary secretion_Homo sapiens_hsa049700.30480745
96Toxoplasmosis_Homo sapiens_hsa051450.29191351
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29155614
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28458640
99Sphingolipid metabolism_Homo sapiens_hsa006000.27051103
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.26067014

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