KRT27

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1citrulline biosynthetic process (GO:0019240)9.13413749
2adhesion of symbiont to host (GO:0044406)8.74058163
3peptide cross-linking (GO:0018149)8.39486081
4linoleic acid metabolic process (GO:0043651)7.17440028
5intermediate filament cytoskeleton organization (GO:0045104)6.78206969
6intermediate filament-based process (GO:0045103)6.56783783
7* hair follicle morphogenesis (GO:0031069)6.23392058
8cell wall macromolecule catabolic process (GO:0016998)6.18731210
9cell wall macromolecule metabolic process (GO:0044036)6.18731210
10epidermis development (GO:0008544)6.13466267
11citrulline metabolic process (GO:0000052)6.05765909
12keratinocyte differentiation (GO:0030216)5.72605516
13long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)5.72468165
14long-chain fatty-acyl-CoA metabolic process (GO:0035336)5.45821007
15very long-chain fatty acid metabolic process (GO:0000038)5.37545118
16establishment of skin barrier (GO:0061436)5.28121573
17bundle of His cell to Purkinje myocyte communication (GO:0086069)5.21982093
18keratinocyte proliferation (GO:0043616)5.14699280
19fatty-acyl-CoA biosynthetic process (GO:0046949)5.08194115
20peptidyl-arginine modification (GO:0018195)5.07646526
21hemidesmosome assembly (GO:0031581)4.72707671
22long-chain fatty acid biosynthetic process (GO:0042759)4.71226150
23retinol metabolic process (GO:0042572)4.71025075
24regulation of water loss via skin (GO:0033561)4.70294255
25skin morphogenesis (GO:0043589)4.69360748
26* hair cycle process (GO:0022405)4.57823407
27* molting cycle process (GO:0022404)4.57823407
28epidermal cell differentiation (GO:0009913)4.48745530
29fatty-acyl-CoA metabolic process (GO:0035337)4.24695751
30thioester biosynthetic process (GO:0035384)4.20754074
31acyl-CoA biosynthetic process (GO:0071616)4.20754074
32positive regulation of keratinocyte differentiation (GO:0045618)4.12746495
33molting cycle (GO:0042303)35.3124363
34hair cycle (GO:0042633)35.3124363
35tooth mineralization (GO:0034505)3.91594369
36lipoxygenase pathway (GO:0019372)3.88374595
37keratinocyte development (GO:0003334)3.81316841
38positive regulation of chemokine secretion (GO:0090197)3.72301306
39alpha-linolenic acid metabolic process (GO:0036109)3.66462758
40primary alcohol metabolic process (GO:0034308)3.46102658
41regulation of chemokine secretion (GO:0090196)3.39359631
42negative regulation of keratinocyte proliferation (GO:0010839)3.38951807
43hair follicle development (GO:0001942)3.36613375
44defense response to fungus (GO:0050832)3.34147564
45negative regulation of establishment of protein localization to plasma membrane (GO:0090005)3.31624585
46positive regulation of hair follicle development (GO:0051798)3.31252748
47positive regulation of hair cycle (GO:0042635)3.31252748
48phosphatidylinositol acyl-chain remodeling (GO:0036149)3.30122250
49regulation of keratinocyte differentiation (GO:0045616)3.23312857
50multicellular organismal water homeostasis (GO:0050891)3.17458305
51regulation of hair follicle development (GO:0051797)3.12695269
52phosphatidylserine acyl-chain remodeling (GO:0036150)3.01718500
53bone trabecula formation (GO:0060346)2.99225112
54triglyceride biosynthetic process (GO:0019432)2.94991145
55epithelium development (GO:0060429)2.91438527
56disruption of cells of other organism (GO:0044364)2.85045480
57killing of cells of other organism (GO:0031640)2.85045480
58gap junction assembly (GO:0016264)2.81005919
59acylglycerol biosynthetic process (GO:0046463)2.78785776
60neutral lipid biosynthetic process (GO:0046460)2.78785776
61phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.78103859
62regulation of hair cycle (GO:0042634)2.77310515
63positive regulation of epidermis development (GO:0045684)2.75691808
64positive regulation of meiotic cell cycle (GO:0051446)2.75209138
65negative regulation of protein localization to plasma membrane (GO:1903077)2.74137381
66regulation of sequestering of triglyceride (GO:0010889)2.71952202
67ectoderm development (GO:0007398)2.70372861
68atrioventricular valve morphogenesis (GO:0003181)2.63538961
69water homeostasis (GO:0030104)2.59140063
70regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.56778285
71primary alcohol catabolic process (GO:0034310)2.55447306
72epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.53249297
73acyl-CoA metabolic process (GO:0006637)2.51708119
74thioester metabolic process (GO:0035383)2.51708119
75response to phenylpropanoid (GO:0080184)2.51668450
76regulation of epidermal cell differentiation (GO:0045604)2.51611153
77regulation of epidermis development (GO:0045682)2.46380343
78detection of bacterium (GO:0016045)2.45381419
79one-carbon compound transport (GO:0019755)2.44062136
80fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.41198018
81ventricular cardiac muscle cell action potential (GO:0086005)2.40849753
82fatty acid elongation (GO:0030497)2.38535986
83carnitine metabolic process (GO:0009437)2.38525260
84negative regulation of cell fate specification (GO:0009996)2.30053780
85wound healing, spreading of epidermal cells (GO:0035313)2.29342544
86phosphatidylserine metabolic process (GO:0006658)2.27937071
87cell surface receptor signaling pathway involved in heart development (GO:0061311)2.27270838
88epithelial cell differentiation involved in prostate gland development (GO:0060742)2.26447269
89regulation of mesenchymal cell apoptotic process (GO:2001053)2.24858996
90unsaturated fatty acid biosynthetic process (GO:0006636)2.24245975
91cranial suture morphogenesis (GO:0060363)2.23576390
92positive regulation of epidermal cell differentiation (GO:0045606)2.22493876
93phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.20353863
94detection of other organism (GO:0098543)2.17505137
95lymph vessel development (GO:0001945)2.12004788
96skin development (GO:0043588)2.10308591
97response to fungus (GO:0009620)2.09736343
98aging (GO:0007568)2.07238233
99positive regulation of monocyte chemotaxis (GO:0090026)2.05311717
100negative regulation of epidermis development (GO:0045683)2.04441895
101fatty acid biosynthetic process (GO:0006633)2.04250859
102outflow tract septum morphogenesis (GO:0003148)2.02988190
103regulation of heart rate by cardiac conduction (GO:0086091)2.01996053
104regulation of cardioblast differentiation (GO:0051890)2.01822892
105planar cell polarity pathway involved in neural tube closure (GO:0090179)2.00168718
106intermediate filament organization (GO:0045109)12.3866343
107keratinization (GO:0031424)10.9278604
108virion attachment to host cell (GO:0019062)10.3496164
109adhesion of symbiont to host cell (GO:0044650)10.3496164
110desmosome organization (GO:0002934)10.1899797
111lateral sprouting from an epithelium (GO:0060601)1.99341042
112epithelial cell-cell adhesion (GO:0090136)1.98624720
113regulation of natural killer cell differentiation (GO:0032823)1.98041411
114cytoskeletal anchoring at plasma membrane (GO:0007016)1.96513999
115regulation of defense response to virus by host (GO:0050691)1.96496401
116regulation of phospholipase A2 activity (GO:0032429)1.95625936
117myotube differentiation (GO:0014902)1.94094515
118phosphatidylcholine acyl-chain remodeling (GO:0036151)1.94041529
119ethanol metabolic process (GO:0006067)1.93033477
120regulation of ruffle assembly (GO:1900027)1.92162486
121cell communication involved in cardiac conduction (GO:0086065)1.91677031
122regulation of keratinocyte proliferation (GO:0010837)1.91533109
123regulation of Wnt signaling pathway involved in heart development (GO:0003307)1.90370840
124phosphatidic acid biosynthetic process (GO:0006654)1.87087126
125phosphatidic acid metabolic process (GO:0046473)1.87087126
126regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)1.84730956
127non-canonical Wnt signaling pathway (GO:0035567)1.83164496
128negative regulation of execution phase of apoptosis (GO:1900118)1.82832730
129ephrin receptor signaling pathway (GO:0048013)1.81415434
130cell-substrate junction assembly (GO:0007044)1.73276061
131regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901211.68666651
132alditol phosphate metabolic process (GO:0052646)1.68009045
133coronary vasculature morphogenesis (GO:0060977)1.66544932
134regulation of transforming growth factor beta2 production (GO:0032909)1.63427902
135G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071991.62395250
136establishment of tissue polarity (GO:0007164)1.62382628
137establishment of planar polarity (GO:0001736)1.62382628
138regulation of secondary heart field cardioblast proliferation (GO:0003266)1.62178119
139regulation of cardioblast proliferation (GO:0003264)1.62178119
140craniofacial suture morphogenesis (GO:0097094)1.61688364
141antigen processing and presentation of endogenous peptide antigen (GO:0002483)1.61563805
142antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)1.61563805
143wound healing, spreading of cells (GO:0044319)1.59624882
144negative regulation of epidermal cell differentiation (GO:0045605)1.59410668
145cardiac conduction (GO:0061337)1.57293856
146negative regulation of cell fate commitment (GO:0010454)1.57126504

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.32556425
2CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human5.02111013
3P63_26484246_Chip-Seq_KERATINOCYTES_Human3.57800790
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.73003443
5CTCF_20526341_ChIP-Seq_ESCs_Human2.33446144
6NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse2.20131807
7TP63_17297297_ChIP-ChIP_HaCaT_Human12.6324032
8PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.93336011
9E2F1_20622854_ChIP-Seq_HELA_Human1.85246385
10TAF2_19829295_ChIP-Seq_ESCs_Human1.83922519
11* BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.79531677
12VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.74906395
13CSB_26484114_Chip-Seq_FIBROBLAST_Human1.73582570
14EGR1_19032775_ChIP-ChIP_M12_Human1.71949727
15NANOG_20526341_ChIP-Seq_ESCs_Human1.71308249
16P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.71164161
17SOX9_24532713_ChIP-Seq_HFSC_Mouse1.70683415
18CTCF_27219007_Chip-Seq_Bcells_Human1.59833473
19P53_21459846_ChIP-Seq_SAOS-2_Human1.58639014
20ERG_20517297_ChIP-Seq_VCAP_Human1.58428218
21TP53_20018659_ChIP-ChIP_R1E_Mouse1.54799776
22FOXO3_23340844_ChIP-Seq_DLD1_Human1.54627138
23MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.53639338
24SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.52307143
25SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.52307143
26RACK7_27058665_Chip-Seq_MCF-7_Human1.50735373
27TP63_22573176_ChIP-Seq_HFKS_Human1.49279176
28LXR_22292898_ChIP-Seq_THP-1_Human1.47859165
29DNAJC2_21179169_ChIP-ChIP_NT2_Human1.47396399
30BCL6_27268052_Chip-Seq_Bcells_Human1.47325517
31YY1_22570637_ChIP-Seq_MALME-3M_Human1.43409566
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.41925994
33ESR1_21235772_ChIP-Seq_MCF-7_Human1.39520225
34BCOR_27268052_Chip-Seq_Bcells_Human1.37778731
35ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.37373971
36UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.36767519
37ATF3_27146783_Chip-Seq_COLON_Human1.36007417
38SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.30861156
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.30447857
40ARNT_22903824_ChIP-Seq_MCF-7_Human1.29372020
41ESR2_21235772_ChIP-Seq_MCF-7_Human1.28994143
42AHR_22903824_ChIP-Seq_MCF-7_Human1.27908331
43PHF8_20622854_ChIP-Seq_HELA_Human1.25840992
44KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.23342510
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.19148937
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.18828026
47P68_20966046_ChIP-Seq_HELA_Human1.18434233
48SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.17455523
49ELF1_20517297_ChIP-Seq_JURKAT_Human1.17291866
50KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16566264
51E2F1_17053090_ChIP-ChIP_MCF-7_Human1.16294013
52CEBPB_22108803_ChIP-Seq_LS180_Human1.16207623
53IKZF1_21737484_ChIP-ChIP_HCT116_Human1.14374345
54TRIM28_21343339_ChIP-Seq_HEK293_Human1.12706783
55JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12264531
56ELK4_26923725_Chip-Seq_MESODERM_Mouse1.10716277
57GATA3_24758297_ChIP-Seq_MCF-7_Human1.10251149
58RAC3_21632823_ChIP-Seq_H3396_Human1.09861173
59TP63_23658742_ChIP-Seq_EP156T_Human1.09541373
60UBF1/2_26484160_Chip-Seq_HMECs_Human1.09186326
61SMC4_20622854_ChIP-Seq_HELA_Human1.08544796
62JARID2_20075857_ChIP-Seq_MESCs_Mouse1.08035652
63P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07556389
64PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.07299936
65JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07198162
66GATA4_25053715_ChIP-Seq_YYC3_Human1.06912967
67TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04361913
68ESR1_20079471_ChIP-ChIP_T-47D_Human1.04207013
69SOX2_21211035_ChIP-Seq_LN229_Human1.00927372
70SPI1_20517297_ChIP-Seq_HL60_Human1.00309579
71SA1_27219007_Chip-Seq_ERYTHROID_Human1.00166785
72KLF5_25053715_ChIP-Seq_YYC3_Human0.99744078
73EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.96792416
74TP53_18474530_ChIP-ChIP_U2OS_Human0.96785774
75RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95492857
76GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.94948425
77ERG_21242973_ChIP-ChIP_JURKAT_Human0.94824676
78SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93128715
79CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.93123520
80FOXH1_21741376_ChIP-Seq_ESCs_Human0.92905984
81RING1B_27294783_Chip-Seq_ESCs_Mouse0.88525919
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88425860
83RUNX1_27514584_Chip-Seq_MCF-7_Human0.87680692
84RXR_22108803_ChIP-Seq_LS180_Human0.87463008
85GATA6_21074721_ChIP-Seq_CACO-2_Human0.86426701
86NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.86376757
87* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.85437373
88GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.85110091
89CDX2_19796622_ChIP-Seq_MESCs_Mouse0.84969131
90RNF2_27304074_Chip-Seq_ESCs_Mouse0.83601037
91SOX2_20726797_ChIP-Seq_SW620_Human0.83371339
92AR_21572438_ChIP-Seq_LNCaP_Human0.78704278
93ZFP281_18757296_ChIP-ChIP_E14_Mouse0.78247989
94EZH2_27294783_Chip-Seq_ESCs_Mouse0.78236098
95CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.77333198
96ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.77008748
97TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.76287967
98ZNF263_19887448_ChIP-Seq_K562_Human0.75905683
99BMI1_23680149_ChIP-Seq_NPCS_Mouse0.75215127
100ZNF217_24962896_ChIP-Seq_MCF-7_Human0.75203381
101CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.75110928
102FOXA1_27270436_Chip-Seq_PROSTATE_Human0.75056745
103FOXA1_25329375_ChIP-Seq_VCAP_Human0.75056745
104KAP1_27257070_Chip-Seq_ESCs_Mouse0.74658193
105ELK3_25401928_ChIP-Seq_HUVEC_Human0.74645588
106CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.74545833
107FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.74308177
108SOX2_27498859_Chip-Seq_STOMACH_Mouse0.74045106
109HTT_18923047_ChIP-ChIP_STHdh_Human0.73810141
110P300_27268052_Chip-Seq_Bcells_Human0.71059251
111SMAD4_21741376_ChIP-Seq_ESCs_Human0.70498283
112HIF1A_21447827_ChIP-Seq_MCF-7_Human0.67916048
113TBX20_22080862_ChIP-Seq_HEART_Mouse0.67881173
114TBX20_22328084_ChIP-Seq_HEART_Mouse0.67881173
115HNFA_21074721_ChIP-Seq_CACO-2_Human0.67643091
116STAT1_20625510_ChIP-Seq_HELA_Human0.65904994
117JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.65423689
118PPARA_22158963_ChIP-Seq_LIVER_Mouse0.65269919
119TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.65183971
120SA1_27219007_Chip-Seq_Bcells_Human0.65098154
121FOXH1_21741376_ChIP-Seq_EPCs_Human0.64213808
122RBPJ_21746931_ChIP-Seq_IB4_Human0.62773480
123MYC_19829295_ChIP-Seq_ESCs_Human0.62529534
124EZH2_27304074_Chip-Seq_ESCs_Mouse0.62273278
125AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.60898535

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology7.95392840
2MP0000647_abnormal_sebaceous_gland6.61672263
3* MP0002098_abnormal_vibrissa_morphology6.42396918
4MP0002796_impaired_skin_barrier5.72339888
5MP0005275_abnormal_skin_tensile5.16221308
6MP0010234_abnormal_vibrissa_follicle5.12888285
7MP0000383_abnormal_hair_follicle4.83886577
8MP0010678_abnormal_skin_adnexa4.26581279
9MP0000377_abnormal_hair_follicle4.21631271
10MP0003705_abnormal_hypodermis_morpholog3.72177683
11MP0000427_abnormal_hair_cycle3.70207819
12MP0005501_abnormal_skin_physiology3.58607377
13MP0002254_reproductive_system_inflammat3.06847652
14MP0001216_abnormal_epidermal_layer2.66433093
15MP0004381_abnormal_hair_follicle2.50958911
16MP0004947_skin_inflammation2.29748002
17MP0010771_integument_phenotype2.29232643
18MP0003878_abnormal_ear_physiology2.24238306
19MP0005377_hearing/vestibular/ear_phenot2.24238306
20MP0001243_abnormal_dermal_layer2.24027293
21* MP0000367_abnormal_coat/_hair2.21237569
22MP0001188_hyperpigmentation2.17735537
23MP0003453_abnormal_keratinocyte_physiol2.17629439
24MP0002060_abnormal_skin_morphology2.13798080
25MP0002234_abnormal_pharynx_morphology1.98757079
26MP0000467_abnormal_esophagus_morphology1.69097098
27MP0009053_abnormal_anal_canal1.54321507
28MP0009931_abnormal_skin_appearance1.49494487
29MP0000762_abnormal_tongue_morphology1.49488429
30MP0003566_abnormal_cell_adhesion1.43827993
31MP0005409_darkened_coat_color1.34736153
32MP0003941_abnormal_skin_development1.19826019
33MP0005174_abnormal_tail_pigmentation1.03505611
34MP0000015_abnormal_ear_pigmentation1.00191910
35MP0005647_abnormal_sex_gland0.99862204
36MP0001191_abnormal_skin_condition0.98209490
37MP0004885_abnormal_endolymph0.96854143
38MP0002095_abnormal_skin_pigmentation0.89147807
39MP0001661_extended_life_span0.87814224
40MP0004264_abnormal_extraembryonic_tissu0.87809264
41MP0004185_abnormal_adipocyte_glucose0.86063057
42MP0001851_eye_inflammation0.78582699
43MP0008438_abnormal_cutaneous_collagen0.75590900
44MP0006035_abnormal_mitochondrial_morpho0.74313729
45MP0001340_abnormal_eyelid_morphology0.68207690
46MP0003315_abnormal_perineum_morphology0.67491920
47MP0001346_abnormal_lacrimal_gland0.67030810
48MP0000566_synostosis0.65347406
49MP0002877_abnormal_melanocyte_morpholog0.65316148
50MP0001849_ear_inflammation0.63677059
51MP0010030_abnormal_orbit_morphology0.62519247
52MP0000627_abnormal_mammary_gland0.57559920
53MP0003755_abnormal_palate_morphology0.50789409
54MP0003191_abnormal_cellular_cholesterol0.49905958
55MP0002282_abnormal_trachea_morphology0.49813019
56MP0002970_abnormal_white_adipose0.49796016
57MP0004782_abnormal_surfactant_physiolog0.48085307
58MP0005023_abnormal_wound_healing0.46762330
59MP0001485_abnormal_pinna_reflex0.45169523
60MP0001784_abnormal_fluid_regulation0.44285007
61MP0002111_abnormal_tail_morphology0.40593273
62MP0002249_abnormal_larynx_morphology0.40568506
63MP0005451_abnormal_body_composition0.40164732
64MP0005075_abnormal_melanosome_morpholog0.39180461
65MP0010352_gastrointestinal_tract_polyps0.35020309
66MP0001984_abnormal_olfaction0.34473323
67MP0004272_abnormal_basement_membrane0.34462976
68MP0000678_abnormal_parathyroid_gland0.33315192
69MP0003385_abnormal_body_wall0.33052584
70MP0000537_abnormal_urethra_morphology0.32287749
71MP0009780_abnormal_chondrocyte_physiolo0.31069403
72MP0009840_abnormal_foam_cell0.30384403
73MP0002163_abnormal_gland_morphology0.29862545
74MP0002177_abnormal_outer_ear0.28414707
75MP0002697_abnormal_eye_size0.26856091
76MP0005503_abnormal_tendon_morphology0.25611616
77MP0003950_abnormal_plasma_membrane0.24793954
78MP0005248_abnormal_Harderian_gland0.24447380
79MP0003763_abnormal_thymus_physiology0.24095247
80MP0001919_abnormal_reproductive_system0.23058013
81MP0005535_abnormal_body_temperature0.22482323
82MP0003329_amyloid_beta_deposits0.21706374
83MP0000432_abnormal_head_morphology0.21320078
84MP0000465_gastrointestinal_hemorrhage0.21132546
85MP0003300_gastrointestinal_ulcer0.21121119
86MP0009379_abnormal_foot_pigmentation0.20496580
87MP0006054_spinal_hemorrhage0.20255273
88MP0003935_abnormal_craniofacial_develop0.17498340
89MP0004019_abnormal_vitamin_homeostasis0.17488798
90MP0004858_abnormal_nervous_system0.15702640
91MP0002006_tumorigenesis0.15583293
92MP0005367_renal/urinary_system_phenotyp0.15362205
93MP0000516_abnormal_urinary_system0.15362205
94MP0004742_abnormal_vestibular_system0.15341303
95MP0001879_abnormal_lymphatic_vessel0.15024818
96MP0002166_altered_tumor_susceptibility0.14609816
97MP0009384_cardiac_valve_regurgitation0.13793156
98MP0005666_abnormal_adipose_tissue0.13429367
99MP0005375_adipose_tissue_phenotype0.13214343
100MP0003448_altered_tumor_morphology0.12940294
101MP0003638_abnormal_response/metabolism_0.12433025
102MP0005076_abnormal_cell_differentiation0.11768683
103MP0003646_muscle_fatigue0.11395596
104MP0000462_abnormal_digestive_system0.11276958
105MP0001186_pigmentation_phenotype0.11177105
106MP0002233_abnormal_nose_morphology0.10900942
107MP0000604_amyloidosis0.10696015
108MP0005193_abnormal_anterior_eye0.09632470
109MP0003045_fibrosis0.09280705
110MP0000013_abnormal_adipose_tissue0.08949756
111MP0001958_emphysema0.08945808
112MP0003011_delayed_dark_adaptation0.08727870
113MP0002009_preneoplasia0.07399244
114MP0000685_abnormal_immune_system0.07236801
115MP0005508_abnormal_skeleton_morphology0.07202212
116MP0003075_altered_response_to0.07115730
117MP0005379_endocrine/exocrine_gland_phen0.06828371
118MP0000733_abnormal_muscle_development0.06484253
119MP0005452_abnormal_adipose_tissue0.06468721
120MP0006138_congestive_heart_failure0.06068134
121MP0001905_abnormal_dopamine_level0.04452795
122MP0004043_abnormal_pH_regulation0.03168540
123MP0001881_abnormal_mammary_gland0.02850693
124MP0009703_decreased_birth_body0.02476388
125MP0002971_abnormal_brown_adipose0.02192363
126MP0005646_abnormal_pituitary_gland0.02035044
127MP0008004_abnormal_stomach_pH0.01987871
128MP0000358_abnormal_cell_content/0.01946845
129MP0000428_abnormal_craniofacial_morphol0.01683816
130MP0008260_abnormal_autophagy0.01322489
131MP0009333_abnormal_splenocyte_physiolog0.00122256
132MP0002118_abnormal_lipid_homeostasis0.00056475
133MP0008789_abnormal_olfactory_epithelium-0.0002424

Predicted human phenotypes

RankGene SetZ-score
1Pili torti (HP:0003777)9.46672332
2Nail dystrophy (HP:0008404)7.34586573
3Abnormality of nail color (HP:0100643)6.00227602
4Abnormal hair laboratory examination (HP:0003328)5.98456557
5Fragile nails (HP:0001808)5.49168982
6Fine hair (HP:0002213)5.39465691
7Absent eyebrow (HP:0002223)5.32889893
8Absent hair (HP:0002298)4.91686015
9Alopecia of scalp (HP:0002293)4.80362125
10Follicular hyperkeratosis (HP:0007502)4.67455450
11Palmoplantar hyperkeratosis (HP:0000972)4.61067700
12Onycholysis (HP:0001806)4.59836150
13Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.33803930
14Palmar hyperkeratosis (HP:0010765)4.33792929
15Thick nail (HP:0001805)4.30207926
16Abnormality of the axillary hair (HP:0100134)4.28508666
17Abnormality of secondary sexual hair (HP:0009888)4.28508666
18Plantar hyperkeratosis (HP:0007556)4.19802114
19Increased IgE level (HP:0003212)4.16045012
20Right ventricular cardiomyopathy (HP:0011663)4.13445743
21Sparse eyelashes (HP:0000653)3.70041625
22Erythema (HP:0010783)3.41781220
23Oral leukoplakia (HP:0002745)3.24230266
24Milia (HP:0001056)3.20566527
25Abnormality of the frontal sinuses (HP:0002687)3.15968405
26Amelogenesis imperfecta (HP:0000705)3.15414560
27Parakeratosis (HP:0001036)2.99556435
28Congenital, generalized hypertrichosis (HP:0004540)2.96220547
29Curly hair (HP:0002212)2.72122357
30Erythroderma (HP:0001019)2.70047683
31Hamartoma of the eye (HP:0010568)2.67927398
32Intention tremor (HP:0002080)2.66194420
33Ridged nail (HP:0001807)2.60287049
34Aplasia cutis congenita (HP:0001057)2.47630349
35Torticollis (HP:0000473)2.45307755
36Neck muscle weakness (HP:0000467)2.44822105
37Natal tooth (HP:0000695)2.40467121
38Dry hair (HP:0011359)2.39286238
39Congenital ichthyosiform erythroderma (HP:0007431)2.33520316
40Advanced eruption of teeth (HP:0006288)2.29833412
41Abnormal blistering of the skin (HP:0008066)2.26735729
42Craniofacial dystonia (HP:0012179)2.07275615
43Corneal erosion (HP:0200020)2.01352315
44Hypohidrosis (HP:0000966)2.00952492
45Hypotrichosis (HP:0001006)14.7801072
46Abnormality of hair growth rate (HP:0011363)11.4076957
47Slow-growing hair (HP:0002217)11.4076957
48Woolly hair (HP:0002224)11.3564303
49Brittle hair (HP:0002299)10.5568512
50Abnormality of the parietal bone (HP:0002696)1.94781300
51Ventricular tachycardia (HP:0004756)1.94319999
52Palmoplantar keratoderma (HP:0000982)1.90756472
53Pruritus (HP:0000989)1.89664697
54Difficulty walking (HP:0002355)1.89411487
55Focal dystonia (HP:0004373)1.89398198
56Abnormality of the pupil (HP:0000615)1.87498773
57Coarse hair (HP:0002208)1.83317072
58Abnormality of permanent molar morphology (HP:0011071)1.82370609
59Abnormality of the dental root (HP:0006486)1.82370609
60Taurodontia (HP:0000679)1.82370609
61Concave nail (HP:0001598)1.81220840
62Ventricular fibrillation (HP:0001663)1.80416758
63Abnormality of molar morphology (HP:0011070)1.79014881
64Abnormality of molar (HP:0011077)1.79014881
65Abnormality of dental color (HP:0011073)1.78977285
66Absent eyelashes (HP:0000561)1.77206922
67Widely patent fontanelles and sutures (HP:0004492)1.70933327
68Recurrent corneal erosions (HP:0000495)1.62799141
69Abnormality of the dental pulp (HP:0006479)1.59242427
70Blepharitis (HP:0000498)1.58993033
71Furrowed tongue (HP:0000221)1.58651199
72Abnormality of the salivary glands (HP:0010286)1.57170844
73Abnormality of the neuromuscular junction (HP:0003398)1.53623444
74Fatigable weakness (HP:0003473)1.53623444
75Abnormality of the aortic arch (HP:0012303)1.52787984
76Urticaria (HP:0001025)1.51761006
77Hyporeflexia of lower limbs (HP:0002600)1.50849243
78Amniotic constriction ring (HP:0009775)1.48844895
79Abnormality of placental membranes (HP:0011409)1.48844895
80Unilateral renal agenesis (HP:0000122)1.47314026
81Acanthosis nigricans (HP:0000956)1.45930775
82Lip pit (HP:0100267)1.42177556
83Heterogeneous (HP:0001425)1.42080738
84Sudden death (HP:0001699)1.41987681
85Carious teeth (HP:0000670)1.38557835
86Craniofacial hyperostosis (HP:0004493)1.36437007
87Keratoconjunctivitis sicca (HP:0001097)1.34829678
88Autoamputation (HP:0001218)1.31898433
89Multifactorial inheritance (HP:0001426)1.31869330
90Anonychia (HP:0001798)1.31505862
91Achilles tendon contracture (HP:0001771)1.29390030
92Conjunctival hamartoma (HP:0100780)1.28871080
93Hamartoma (HP:0010566)1.26644437
94Distal lower limb muscle weakness (HP:0009053)1.25930125
95Hyperhidrosis (HP:0000975)1.24476169
96Abnormality of the fingernails (HP:0001231)1.24097747
97Split foot (HP:0001839)1.23535064
98Ectropion (HP:0000656)1.23492877
99Sparse scalp hair (HP:0002209)1.23042276
100Selective tooth agenesis (HP:0001592)1.22886431
101Melanocytic nevus (HP:0000995)1.22776989
102Skin ulcer (HP:0200042)1.22484503
103Widely spaced teeth (HP:0000687)1.22227294
104Abnormality of the Achilles tendon (HP:0005109)1.21475362
105Atrophic scars (HP:0001075)1.21365187
106Hypergammaglobulinemia (HP:0010702)1.20177451
107Variable expressivity (HP:0003828)1.19616474
108Keratoconjunctivitis (HP:0001096)1.18228410
109Neonatal onset (HP:0003623)1.18194427
110Gangrene (HP:0100758)1.17877128
111Aplasia involving bones of the upper limbs (HP:0009823)1.15787484
112Aplasia of the phalanges of the hand (HP:0009802)1.15787484
113Aplasia involving bones of the extremities (HP:0009825)1.15787484
114Conical tooth (HP:0000698)1.13911306
115Laryngomalacia (HP:0001601)1.12874542
116Abnormality of the gastric mucosa (HP:0004295)1.10600945
117Increased connective tissue (HP:0009025)1.10492358
118Lack of skin elasticity (HP:0100679)1.09215075
119Septate vagina (HP:0001153)1.08127410
120Round ear (HP:0100830)1.07601468
121Wide cranial sutures (HP:0010537)1.07502713
122Dry skin (HP:0000958)1.05273422
123Nasolacrimal duct obstruction (HP:0000579)1.02943907
124Hypoplastic labia majora (HP:0000059)1.02683926
125Neonatal short-limb short stature (HP:0008921)0.99225046
126Papilloma (HP:0012740)0.99103557
127Verrucae (HP:0200043)0.99103557
128Hydroureter (HP:0000072)0.98861258
129Seborrheic dermatitis (HP:0001051)0.98760377
130Dehydration (HP:0001944)0.97129946
131Generalized hyperpigmentation (HP:0007440)0.93934624
132Neonatal death (HP:0003811)0.93227578
133Xerostomia (HP:0000217)0.93130106
134Abnormality of the labia majora (HP:0012881)0.91416822

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.36774452
2FER4.19103727
3MAPKAPK34.00092555
4MAP3K63.85689164
5ERN13.78095663
6EPHB23.24644368
7STK243.09887414
8TAOK13.06274212
9MAP3K32.75644632
10TRIB32.67454463
11LATS12.55043598
12MAP3K22.49609610
13MAP3K112.09107076
14RPS6KB21.96507917
15EEF2K1.89288246
16MAPKAPK51.68745175
17EPHB11.67063957
18LATS21.66532375
19MAP2K61.62905205
20STK391.62775758
21PIK3CG1.61749863
22PRPF4B1.59604804
23TTN1.57446399
24FGFR21.53918546
25MYLK1.46884824
26BCR1.44863460
27MAPK71.36002519
28FGFR41.31333255
29MAP3K11.30561513
30LMTK21.29006064
31NME11.28613756
32RIPK11.23764228
33FGFR31.23409498
34BMX1.21731641
35CDK61.20525771
36PKN21.20423957
37KSR21.19321821
38BLK1.15749668
39FGFR11.13117125
40PDGFRA1.11806593
41MAPKAPK21.07247237
42MST1R1.07096156
43MAP2K31.06540240
44PTK61.04379858
45SMG11.02209437
46MAP3K71.00849601
47MAP3K120.96795815
48LRRK20.92846517
49RPS6KB10.92532765
50MAP3K90.91560312
51SIK10.89005529
52PRKD20.88470349
53PDK20.87547596
54PBK0.87257393
55RPS6KA40.86319957
56PTK20.83228694
57MAP2K40.82456591
58MAP3K100.80145738
59MAP2K10.77733518
60STK380.75800299
61MARK20.75362732
62STK38L0.73466321
63PIM20.70884426
64DYRK1B0.69879076
65PAK40.69092555
66MET0.68011823
67PRKD10.66661140
68PINK10.65775997
69PAK30.65196918
70TESK10.64638953
71IRAK10.64108373
72SGK2230.62591519
73SGK4940.62591519
74ABL20.62115388
75DDR20.61210040
76PRKCI0.60047256
77ERBB40.59722381
78TRPM70.59711347
79PRKCH0.59087874
80CDK190.58385250
81OXSR10.56397571
82NME20.54868600
83MAP3K50.52608081
84NEK60.52219236
85ERBB20.52171745
86RET0.51819526
87STK30.51332934
88TGFBR10.50494995
89JAK10.50309873
90TYRO30.49822638
91EPHA40.49586570
92EPHA30.48015528
93PAK20.47523184
94NTRK20.46872126
95RPS6KA10.46783849
96PAK60.45771573
97CDC42BPA0.45494403
98IRAK30.44937993
99MAPK40.44530810
100MINK10.44175344
101CSNK1E0.43229900
102ALK0.42670174
103TYK20.42607479
104NEK10.42505386
105KIT0.41923608
106MAPK120.40621064
107GSK3A0.40185234
108OBSCN0.39359571
109CDK70.38532677
110ADRBK10.36995921
111IKBKB0.36746514
112SGK30.36470415
113MAP2K20.36237469
114PRKAA20.35165747
115MST40.35152865
116CLK10.33721390
117JAK20.32846711
118FYN0.29700059
119MAP3K80.28595960
120LIMK10.28388426
121GRK60.27510769
122MATK0.26968566
123STK110.26389055
124NTRK10.25874199
125NLK0.25328814
126ERBB30.25143745
127RPS6KA20.24923226
128SRC0.24858305
129PDPK10.24583881
130ILK0.24303626
131IRAK20.24260798
132CSNK1A10.24157045
133MTOR0.23442070
134MAPK80.23272986
135PRKACG0.22698115
136MAPK90.22481254
137TGFBR20.22132820
138PRKACA0.21504171
139SGK10.21403825
140AURKB0.20646822
141SGK20.20287791

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.87718825
2Linoleic acid metabolism_Homo sapiens_hsa005914.84771095
3Vitamin digestion and absorption_Homo sapiens_hsa049774.15385588
4Fat digestion and absorption_Homo sapiens_hsa049753.17507212
5Fatty acid biosynthesis_Homo sapiens_hsa000612.80336057
6Fatty acid elongation_Homo sapiens_hsa000622.61378261
7Ether lipid metabolism_Homo sapiens_hsa005652.57744311
8Basal cell carcinoma_Homo sapiens_hsa052172.50663607
9Sphingolipid metabolism_Homo sapiens_hsa006001.94872392
10Retinol metabolism_Homo sapiens_hsa008301.94075152
11Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.86299375
12Arachidonic acid metabolism_Homo sapiens_hsa005901.82323209
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.80794689
14Phenylalanine metabolism_Homo sapiens_hsa003601.75260029
15Melanogenesis_Homo sapiens_hsa049161.67209373
16VEGF signaling pathway_Homo sapiens_hsa043701.67087292
17Hedgehog signaling pathway_Homo sapiens_hsa043401.62519196
18Axon guidance_Homo sapiens_hsa043601.58362347
19Thyroid cancer_Homo sapiens_hsa052161.43037642
20Glycerolipid metabolism_Homo sapiens_hsa005611.39782329
21Bladder cancer_Homo sapiens_hsa052191.38727726
22Glioma_Homo sapiens_hsa052141.37824086
23Caffeine metabolism_Homo sapiens_hsa002321.37749130
24Hippo signaling pathway_Homo sapiens_hsa043901.37340932
25Proteoglycans in cancer_Homo sapiens_hsa052051.32537523
26Histidine metabolism_Homo sapiens_hsa003401.29972296
27Vascular smooth muscle contraction_Homo sapiens_hsa042701.28674063
28Acute myeloid leukemia_Homo sapiens_hsa052211.22789557
29Dorso-ventral axis formation_Homo sapiens_hsa043201.19379468
30Mineral absorption_Homo sapiens_hsa049781.18133227
31GnRH signaling pathway_Homo sapiens_hsa049121.15820659
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15123233
33Tight junction_Homo sapiens_hsa045301.13147051
34Ovarian steroidogenesis_Homo sapiens_hsa049131.10454529
35Pancreatic secretion_Homo sapiens_hsa049721.09993380
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.06345951
37Collecting duct acid secretion_Homo sapiens_hsa049661.05782026
38Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.01643591
39Adherens junction_Homo sapiens_hsa045201.01577206
40Long-term potentiation_Homo sapiens_hsa047201.01292786
41PPAR signaling pathway_Homo sapiens_hsa033201.00273218
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.00161209
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.99930194
44ECM-receptor interaction_Homo sapiens_hsa045120.99774514
45Endometrial cancer_Homo sapiens_hsa052130.97668867
46Nitrogen metabolism_Homo sapiens_hsa009100.95917326
47Glycerophospholipid metabolism_Homo sapiens_hsa005640.94055958
48Steroid biosynthesis_Homo sapiens_hsa001000.94018738
49Non-small cell lung cancer_Homo sapiens_hsa052230.93554651
50Tyrosine metabolism_Homo sapiens_hsa003500.89932581
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.87217625
52Wnt signaling pathway_Homo sapiens_hsa043100.85828903
53Ras signaling pathway_Homo sapiens_hsa040140.83071602
54Estrogen signaling pathway_Homo sapiens_hsa049150.81078996
55Long-term depression_Homo sapiens_hsa047300.79450263
56Pertussis_Homo sapiens_hsa051330.79364427
57Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.78213880
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.77605336
59Amoebiasis_Homo sapiens_hsa051460.77481236
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76437221
61beta-Alanine metabolism_Homo sapiens_hsa004100.74349558
62Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71789115
63MicroRNAs in cancer_Homo sapiens_hsa052060.65673228
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.63944544
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.63429080
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62295098
67Lysosome_Homo sapiens_hsa041420.61774937
68Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61468446
69Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.61368404
70Gastric acid secretion_Homo sapiens_hsa049710.61100866
71Hepatitis C_Homo sapiens_hsa051600.60544956
72Insulin resistance_Homo sapiens_hsa049310.60151436
73Protein digestion and absorption_Homo sapiens_hsa049740.59192062
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.59131487
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58558171
76Staphylococcus aureus infection_Homo sapiens_hsa051500.57427710
77Renin secretion_Homo sapiens_hsa049240.57196532
78Rap1 signaling pathway_Homo sapiens_hsa040150.56099694
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55581077
80Gap junction_Homo sapiens_hsa045400.55322932
81Pyruvate metabolism_Homo sapiens_hsa006200.55310830
82Peroxisome_Homo sapiens_hsa041460.54044689
83Serotonergic synapse_Homo sapiens_hsa047260.53701508
84TGF-beta signaling pathway_Homo sapiens_hsa043500.53511400
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52854838
86Fatty acid metabolism_Homo sapiens_hsa012120.52588400
87Salmonella infection_Homo sapiens_hsa051320.52301149
88Focal adhesion_Homo sapiens_hsa045100.52079386
89Phototransduction_Homo sapiens_hsa047440.51760908
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.51647712
91Renal cell carcinoma_Homo sapiens_hsa052110.50829390
92ErbB signaling pathway_Homo sapiens_hsa040120.50609630
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47749492
94Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46797783
95Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46627048
96Arginine and proline metabolism_Homo sapiens_hsa003300.46384587
97Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45524946
98Platelet activation_Homo sapiens_hsa046110.45396073
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45324064
100Oxytocin signaling pathway_Homo sapiens_hsa049210.44024452
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43689943
102Butanoate metabolism_Homo sapiens_hsa006500.43678669
103Salivary secretion_Homo sapiens_hsa049700.41867246
104Chronic myeloid leukemia_Homo sapiens_hsa052200.41556712
105Olfactory transduction_Homo sapiens_hsa047400.41256254
106Melanoma_Homo sapiens_hsa052180.40048339
107p53 signaling pathway_Homo sapiens_hsa041150.39334847
108Notch signaling pathway_Homo sapiens_hsa043300.38969625
109Prolactin signaling pathway_Homo sapiens_hsa049170.38521343
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37757262
111Prion diseases_Homo sapiens_hsa050200.37471052
112Fatty acid degradation_Homo sapiens_hsa000710.37263905
113Toxoplasmosis_Homo sapiens_hsa051450.36935544
114Pathways in cancer_Homo sapiens_hsa052000.35577023
115Tuberculosis_Homo sapiens_hsa051520.35407254
116Chemical carcinogenesis_Homo sapiens_hsa052040.34966044
117Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.34712052
118Insulin signaling pathway_Homo sapiens_hsa049100.34673170
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34252528
120Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.34137678
121Amphetamine addiction_Homo sapiens_hsa050310.34010176
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33816194
123Primary bile acid biosynthesis_Homo sapiens_hsa001200.31120297
124Glucagon signaling pathway_Homo sapiens_hsa049220.28745941
125Vibrio cholerae infection_Homo sapiens_hsa051100.27827104
126Choline metabolism in cancer_Homo sapiens_hsa052310.27255728
127Steroid hormone biosynthesis_Homo sapiens_hsa001400.26235028
128Malaria_Homo sapiens_hsa051440.24837558
129Adipocytokine signaling pathway_Homo sapiens_hsa049200.22292614
130Ribosome_Homo sapiens_hsa030100.21162424
131Synaptic vesicle cycle_Homo sapiens_hsa047210.20564621
132Circadian entrainment_Homo sapiens_hsa047130.20334659
133Renin-angiotensin system_Homo sapiens_hsa046140.20018620
134Sulfur relay system_Homo sapiens_hsa041220.19454684
135Inositol phosphate metabolism_Homo sapiens_hsa005620.17376042
136Arginine biosynthesis_Homo sapiens_hsa002200.16798368
137Endocytosis_Homo sapiens_hsa041440.16399121
138Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.13517784
139Phospholipase D signaling pathway_Homo sapiens_hsa040720.13021509
140Circadian rhythm_Homo sapiens_hsa047100.12885815

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