KRT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is expressed largely in the upper spinous layer of epidermal keratinocytes and mutations in this gene have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1extracellular fibril organization (GO:0043206)8.72329335
2water homeostasis (GO:0030104)8.40877067
3adhesion of symbiont to host cell (GO:0044650)8.32821417
4virion attachment to host cell (GO:0019062)8.32821417
5desmosome organization (GO:0002934)7.93857518
6protein heterotrimerization (GO:0070208)7.82484467
7linoleic acid metabolic process (GO:0043651)7.61320419
8fibril organization (GO:0097435)7.43654145
9collagen fibril organization (GO:0030199)7.28962411
10* keratinocyte proliferation (GO:0043616)6.99081237
11adhesion of symbiont to host (GO:0044406)6.88015037
12hemidesmosome assembly (GO:0031581)6.51600586
13bone trabecula formation (GO:0060346)6.20105722
14positive regulation of Rho protein signal transduction (GO:0035025)6.11378276
15* keratinization (GO:0031424)6.05769961
16collagen catabolic process (GO:0030574)5.92659694
17collagen metabolic process (GO:0032963)5.91249097
18lipoxygenase pathway (GO:0019372)5.79564587
19multicellular organismal macromolecule metabolic process (GO:0044259)5.60666514
20skin morphogenesis (GO:0043589)5.57048338
21skin development (GO:0043588)5.54030545
22multicellular organismal catabolic process (GO:0044243)5.45658839
23multicellular organismal metabolic process (GO:0044236)5.27573618
24sequestering of extracellular ligand from receptor (GO:0035581)5.22014682
25phosphatidylinositol acyl-chain remodeling (GO:0036149)5.21202217
26phosphatidylserine acyl-chain remodeling (GO:0036150)5.19018265
27peptide cross-linking (GO:0018149)5.13307979
28endodermal cell differentiation (GO:0035987)5.12679464
29hair follicle morphogenesis (GO:0031069)5.04077973
30keratinocyte development (GO:0003334)4.95409209
31extracellular matrix disassembly (GO:0022617)4.65378197
32bundle of His cell to Purkinje myocyte communication (GO:0086069)4.54837626
33polarized epithelial cell differentiation (GO:0030859)4.39981299
34keratinocyte differentiation (GO:0030216)4.31969269
35plasma membrane repair (GO:0001778)4.23292984
36establishment of tissue polarity (GO:0007164)4.11187456
37establishment of planar polarity (GO:0001736)4.11187456
38intermediate filament organization (GO:0045109)4.04516216
39phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.00491239
40regulation of keratinocyte differentiation (GO:0045616)4.00311417
41cellular response to amino acid stimulus (GO:0071230)3.97835756
42phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.81664080
43hair cycle process (GO:0022405)3.75529287
44molting cycle process (GO:0022404)3.75529287
45retinol metabolic process (GO:0042572)3.75403346
46phospholipid efflux (GO:0033700)3.71956067
47detection of bacterium (GO:0016045)3.67617077
48fibrinolysis (GO:0042730)3.62167577
49long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.58743767
50phosphatidylcholine acyl-chain remodeling (GO:0036151)3.54948810
51* epithelium development (GO:0060429)3.40239585
52response to phenylpropanoid (GO:0080184)3.39977104
53very long-chain fatty acid metabolic process (GO:0000038)3.39535782
54regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.38526029
55embryonic retina morphogenesis in camera-type eye (GO:0060059)3.35404484
56positive regulation of keratinocyte differentiation (GO:0045618)3.33487230
57long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.30734090
58detection of other organism (GO:0098543)3.29379328
59regulation of neuron migration (GO:2001222)3.29099716
60positive regulation of epidermal cell differentiation (GO:0045606)3.28928339
61regulation of Rho protein signal transduction (GO:0035023)3.26017880
62regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.16354251
63positive regulation of cholesterol efflux (GO:0010875)3.15829792
64cytoskeletal anchoring at plasma membrane (GO:0007016)3.14912981
65phosphatidylserine metabolic process (GO:0006658)3.14438967
66epidermal cell differentiation (GO:0009913)3.12788667
67gap junction assembly (GO:0016264)3.12448824
68positive regulation of chemokine secretion (GO:0090197)3.11085175
69ceramide biosynthetic process (GO:0046513)3.10623368
70negative regulation of keratinocyte proliferation (GO:0010839)3.09555473
71one-carbon compound transport (GO:0019755)3.08900545
72extracellular matrix assembly (GO:0085029)3.08456018
73phospholipid catabolic process (GO:0009395)3.02261333
74regulation of chemokine secretion (GO:0090196)2.97293641
75cellular response to antibiotic (GO:0071236)2.95443975
76positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.94070404
77ectoderm development (GO:0007398)2.93031442
78primary alcohol metabolic process (GO:0034308)2.91278414
79regulation of keratinocyte proliferation (GO:0010837)2.88793169
80fatty-acyl-CoA biosynthetic process (GO:0046949)2.87963395
81regulation of epidermal cell differentiation (GO:0045604)2.84066468
82cell-substrate junction assembly (GO:0007044)2.83750083
83polyol transport (GO:0015791)2.82613768
84peripheral nervous system axon ensheathment (GO:0032292)2.82302569
85myelination in peripheral nervous system (GO:0022011)2.82302569
86unsaturated fatty acid biosynthetic process (GO:0006636)2.81941660
87hair follicle development (GO:0001942)2.80518423
88positive regulation of sterol transport (GO:0032373)2.80392293
89positive regulation of cholesterol transport (GO:0032376)2.80392293
90regulation of natural killer cell differentiation (GO:0032823)2.79841936
91negative regulation of interferon-gamma production (GO:0032689)2.77189370
92fatty-acyl-CoA metabolic process (GO:0035337)2.75821996
93long-chain fatty acid biosynthetic process (GO:0042759)2.74847583
94planar cell polarity pathway involved in neural tube closure (GO:0090179)2.74274840
95prostanoid biosynthetic process (GO:0046457)2.72958722
96prostaglandin biosynthetic process (GO:0001516)2.72958722
97cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.72660435
98cell-matrix adhesion (GO:0007160)2.69120410
99positive regulation of epidermis development (GO:0045684)2.67896245
100epithelial cell differentiation involved in prostate gland development (GO:0060742)2.65014326
101positive regulation of small GTPase mediated signal transduction (GO:0051057)2.64317880
102regulation of epidermis development (GO:0045682)2.63622663
103positive regulation of Ras protein signal transduction (GO:0046579)2.61046235
104protein trimerization (GO:0070206)2.61004433
105primary alcohol catabolic process (GO:0034310)2.59052126
106mitotic G1 DNA damage checkpoint (GO:0031571)2.57964549
107surfactant homeostasis (GO:0043129)2.57296261
108wound healing (GO:0042060)2.56907125
109extracellular matrix organization (GO:0030198)2.55885628
110camera-type eye morphogenesis (GO:0048593)2.55808033
111intestinal epithelial cell development (GO:0060576)2.55193021
112extracellular structure organization (GO:0043062)2.54793924
113alditol phosphate metabolic process (GO:0052646)2.51954633
114regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.50107109
115wound healing, spreading of epidermal cells (GO:0035313)2.47935709
116regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.47507116
117molting cycle (GO:0042303)2.47117712
118hair cycle (GO:0042633)2.47117712
119epithelial cell-cell adhesion (GO:0090136)2.45524817
120icosanoid secretion (GO:0032309)2.45479821
121arachidonic acid secretion (GO:0050482)2.45479821
122digestive tract development (GO:0048565)2.44174841
123fatty acid elongation (GO:0030497)2.43814532
124melanin biosynthetic process (GO:0042438)2.43063982
125regulation of glomerular filtration (GO:0003093)2.42986289
126extracellular negative regulation of signal transduction (GO:1900116)2.42812007
127extracellular regulation of signal transduction (GO:1900115)2.42812007
128sphingolipid biosynthetic process (GO:0030148)2.40712597
129eyelid development in camera-type eye (GO:0061029)2.39822805
130gland morphogenesis (GO:0022612)2.39103702
131establishment of nucleus localization (GO:0040023)2.38121166
132myoblast fusion (GO:0007520)2.36833372
133neuron projection extension involved in neuron projection guidance (GO:1902284)2.36497941
134axon extension involved in axon guidance (GO:0048846)2.36497941
135trabecula formation (GO:0060343)2.36273508
136negative regulation of cell fate specification (GO:0009996)2.36266589
137G1 DNA damage checkpoint (GO:0044783)2.36177551
138negative regulation of epidermal cell differentiation (GO:0045605)2.35987087
139* epidermis development (GO:0008544)2.35773642
140phosphatidylglycerol metabolic process (GO:0046471)2.34950393
141genitalia morphogenesis (GO:0035112)2.34676257
142negative regulation of heart growth (GO:0061117)2.33395264
143negative regulation of cardiac muscle tissue growth (GO:0055022)2.33395264
144intermediate filament cytoskeleton organization (GO:0045104)2.32543275
145prostate gland epithelium morphogenesis (GO:0060740)2.31607025
146mitotic G1/S transition checkpoint (GO:0044819)2.30755542
147atrioventricular valve morphogenesis (GO:0003181)2.29654070
148regulation of heart rate by cardiac conduction (GO:0086091)2.28916354
149cell-substrate adhesion (GO:0031589)2.26452720
150lateral sprouting from an epithelium (GO:0060601)2.26208075
151dendritic spine morphogenesis (GO:0060997)2.26048988
152syncytium formation by plasma membrane fusion (GO:0000768)2.25850764
153cell communication involved in cardiac conduction (GO:0086065)2.25850362
154blood vessel development (GO:0001568)2.25174715
155negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.24523230
156intermediate filament-based process (GO:0045103)2.21826132
157lung lobe morphogenesis (GO:0060463)2.21658164
158regulation of cholesterol efflux (GO:0010874)2.19399688
159regulation of cardiac muscle cell apoptotic process (GO:0010665)2.18010728
160ventricular cardiac muscle cell action potential (GO:0086005)2.15983178
161negative regulation of catenin import into nucleus (GO:0035414)2.14779738
162blood vessel maturation (GO:0001955)2.13126843
163cerebral cortex development (GO:0021987)2.11164765
164cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.10817300
165chemical homeostasis within a tissue (GO:0048875)2.09592377
166regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.09094780
167non-canonical Wnt signaling pathway (GO:0035567)2.08314758
168metanephric nephron tubule development (GO:0072234)2.08166855
169metanephric tubule development (GO:0072170)2.08166855
170negative regulation of protein localization to plasma membrane (GO:1903077)2.08096823
171face morphogenesis (GO:0060325)2.05187393
172establishment of skin barrier (GO:0061436)18.6580991
173regulation of water loss via skin (GO:0033561)15.6830003
174multicellular organismal water homeostasis (GO:0050891)10.1099960

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.74974542
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.84643627
3PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.81408789
4AR_21572438_ChIP-Seq_LNCaP_Human2.46427243
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.29020503
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.15804427
7SOX9_24532713_ChIP-Seq_HFSC_Mouse2.14241045
8ZNF217_24962896_ChIP-Seq_MCF-7_Human2.01451961
9ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.93170907
10BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.92757144
11DROSHA_22980978_ChIP-Seq_HELA_Human1.91529934
12CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.83790034
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.76281305
14BCAT_22108803_ChIP-Seq_LS180_Human1.62879556
15ESR1_21235772_ChIP-Seq_MCF-7_Human1.61552535
16RNF2_18974828_ChIP-Seq_MESCs_Mouse1.60969679
17EZH2_18974828_ChIP-Seq_MESCs_Mouse1.60969679
18P63_26484246_Chip-Seq_KERATINOCYTES_Human1.58532436
19TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.57804126
20TP53_18474530_ChIP-ChIP_U2OS_Human1.56407822
21FOXO3_23340844_ChIP-Seq_DLD1_Human1.54175561
22EGR1_19032775_ChIP-ChIP_M12_Human1.54013854
23CJUN_26792858_Chip-Seq_BT549_Human1.50604391
24TCF4_18268006_ChIP-ChIP_LS174T_Human1.49765444
25HIF1A_21447827_ChIP-Seq_MCF-7_Human1.48955095
26EZH2_27304074_Chip-Seq_ESCs_Mouse1.47352195
27SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.45908793
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43747622
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.43517022
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.43101034
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.42942961
32ZNF263_19887448_ChIP-Seq_K562_Human1.42162674
33BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.41679552
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.39513051
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.39160132
36ESR1_20079471_ChIP-ChIP_T-47D_Human1.38884042
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.38594704
38AHR_22903824_ChIP-Seq_MCF-7_Human1.38216385
39TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37250444
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.35317168
41ESR2_21235772_ChIP-Seq_MCF-7_Human1.35314377
42RNF2_27304074_Chip-Seq_ESCs_Mouse1.35111305
43GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.34464105
44TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.33841778
45MTF2_20144788_ChIP-Seq_MESCs_Mouse1.32765450
46JARID2_20064375_ChIP-Seq_MESCs_Mouse1.30883248
47EED_16625203_ChIP-ChIP_MESCs_Mouse1.30388698
48* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.29368576
49RXR_22108803_ChIP-Seq_LS180_Human1.28247123
50GBX2_23144817_ChIP-Seq_PC3_Human1.27148015
51SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.27043308
52WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.26619291
53NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.26461852
54UBF1/2_26484160_Chip-Seq_HMECs_Human1.26087158
55EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25204093
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.25005762
57ARNT_22903824_ChIP-Seq_MCF-7_Human1.24604559
58GATA6_21074721_ChIP-Seq_CACO-2_Human1.24497442
59TP53_16413492_ChIP-PET_HCT116_Human1.23780024
60EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.23421164
61EZH2_22144423_ChIP-Seq_EOC_Human1.21330683
62TP63_23658742_ChIP-Seq_EP156T_Human1.21187729
63RUNX1_27514584_Chip-Seq_MCF-7_Human1.21094397
64GATA3_24758297_ChIP-Seq_MCF-7_Human1.20108724
65* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17466294
66KDM2B_26808549_Chip-Seq_K562_Human1.16682637
67CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.15957573
68SUZ12_27294783_Chip-Seq_ESCs_Mouse1.15107960
69EZH2_27294783_Chip-Seq_ESCs_Mouse1.14474969
70ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.13998926
71GATA1_22025678_ChIP-Seq_K562_Human1.13846434
72KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11571120
73NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11290473
74NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11290473
75EP300_21415370_ChIP-Seq_HL-1_Mouse1.11054877
76CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10286506
77RACK7_27058665_Chip-Seq_MCF-7_Human1.09004776
78WT1_19549856_ChIP-ChIP_CCG9911_Human1.08291393
79SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.07714653
80SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.06841364
81SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.06841364
82SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06646592
83RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05794625
84VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.05201094
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04602008
86GATA2_21666600_ChIP-Seq_HMVEC_Human1.04065340
87FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03804378
88ISL1_27105846_Chip-Seq_CPCs_Mouse1.03226340
89SMAD4_21799915_ChIP-Seq_A2780_Human1.01110087
90PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00330916
91CTCF_27219007_Chip-Seq_Bcells_Human0.99956034
92KLF5_25053715_ChIP-Seq_YYC3_Human0.99914711
93CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99714750
94LXR_22158963_ChIP-Seq_LIVER_Mouse0.99196817
95CDX2_20551321_ChIP-Seq_CACO-2_Human0.98358809
96SMAD3_21741376_ChIP-Seq_HESCs_Human0.97872626
97ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.97678184
98CLOCK_20551151_ChIP-Seq_293T_Human0.97533366
99P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.97249311
100ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97167132
101SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95384829
102FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.94902551
103AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94167085
104KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.93857359
105CTCF_20526341_ChIP-Seq_ESCs_Human0.93526685
106BRD4_25478319_ChIP-Seq_HGPS_Human0.92874549
107SMAD3_21741376_ChIP-Seq_EPCs_Human0.92431071
108P300_27058665_Chip-Seq_ZR-75-30cells_Human0.92320368
109* TP63_22573176_ChIP-Seq_HFKS_Human0.90750503
110STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89786077
111PPAR_26484153_Chip-Seq_NCI-H1993_Human0.89642716
112TCF4_22108803_ChIP-Seq_LS180_Human0.88706931
113* GATA1_19941826_ChIP-Seq_K562_Human0.88508042
114RING1B_27294783_Chip-Seq_ESCs_Mouse0.88377609
115SOX2_21211035_ChIP-Seq_LN229_Gbm0.88338470
116TBX20_22080862_ChIP-Seq_HEART_Mouse0.88151640
117TBX20_22328084_ChIP-Seq_HEART_Mouse0.88151640
118DNAJC2_21179169_ChIP-ChIP_NT2_Human0.87731173
119SOX2_20726797_ChIP-Seq_SW620_Human0.87447581
120* BCOR_27268052_Chip-Seq_Bcells_Human0.86646357
121RING1B_27294783_Chip-Seq_NPCs_Mouse0.84823944
122KDM2B_26808549_Chip-Seq_SUP-B15_Human0.84387584
123UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.84334007
124TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83932900
125CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.83919608
126LXR_22292898_ChIP-Seq_THP-1_Human0.83458890
127GATA4_25053715_ChIP-Seq_YYC3_Human0.82971883
128* ERG_20517297_ChIP-Seq_VCAP_Human0.82010055
129* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.79975043
130HNFA_21074721_ChIP-Seq_CACO-2_Human0.78274032
131GATA6_25053715_ChIP-Seq_YYC3_Human0.77475774
132PPARA_22158963_ChIP-Seq_LIVER_Mouse0.77381776
133* SMC4_20622854_ChIP-Seq_HELA_Human0.77298020
134FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.75177373
135VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.73967191
136FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.73675988
137PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.73440824
138* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.72739642
139TAF2_19829295_ChIP-Seq_ESCs_Human0.72390010
140PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.71890534
141RBPJ_21746931_ChIP-Seq_IB4_Human0.71763178
142ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.69087170
143CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.68283826
144GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.67756847
145* E2F1_20622854_ChIP-Seq_HELA_Human0.67138556
146* ATF3_27146783_Chip-Seq_COLON_Human0.66694028
147* P53_21459846_ChIP-Seq_SAOS-2_Human0.66130185
148FOXM1_26456572_ChIP-Seq_MCF-7_Human0.64742501
149TBL1_22424771_ChIP-Seq_293T_Human0.64553038
150* BCL6_27268052_Chip-Seq_Bcells_Human0.64384484
151TP53_20018659_ChIP-ChIP_R1E_Mouse0.63417832
152* SMAD4_21741376_ChIP-Seq_ESCs_Human0.63230868
153CEBPB_22108803_ChIP-Seq_LS180_Human0.61137683
154ELK3_25401928_ChIP-Seq_HUVEC_Human0.61104834

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen9.85715833
2MP0005275_abnormal_skin_tensile7.72196706
3MP0002796_impaired_skin_barrier5.32970591
4MP0003705_abnormal_hypodermis_morpholog4.50750794
5MP0002060_abnormal_skin_morphology4.19797955
6MP0000579_abnormal_nail_morphology3.69190678
7MP0005503_abnormal_tendon_morphology3.34054715
8MP0005501_abnormal_skin_physiology3.14349248
9MP0003941_abnormal_skin_development3.08073810
10MP0001958_emphysema2.72677114
11MP0010771_integument_phenotype2.67290474
12MP0002254_reproductive_system_inflammat2.39217274
13MP0010234_abnormal_vibrissa_follicle2.29514652
14MP0001243_abnormal_dermal_layer2.14336610
15* MP0002095_abnormal_skin_pigmentation2.12531233
16MP0003191_abnormal_cellular_cholesterol2.12004423
17MP0003011_delayed_dark_adaptation1.97213528
18MP0000383_abnormal_hair_follicle1.93119706
19MP0005257_abnormal_intraocular_pressure1.93047571
20MP0004947_skin_inflammation1.92498324
21* MP0001216_abnormal_epidermal_layer1.88341258
22MP0003279_aneurysm1.84928798
23MP0005075_abnormal_melanosome_morpholog1.82722188
24MP0010678_abnormal_skin_adnexa1.80067557
25MP0003566_abnormal_cell_adhesion1.53225396
26MP0000427_abnormal_hair_cycle1.47884536
27MP0000751_myopathy1.40491830
28* MP0009931_abnormal_skin_appearance1.35758733
29MP0000647_abnormal_sebaceous_gland1.32911594
30MP0002108_abnormal_muscle_morphology1.31529822
31MP0006054_spinal_hemorrhage1.30828668
32MP0000377_abnormal_hair_follicle1.23054554
33MP0005171_absent_coat_pigmentation1.21850357
34MP0002006_tumorigenesis1.21114869
35MP0003252_abnormal_bile_duct1.15192663
36MP0003453_abnormal_keratinocyte_physiol1.13963212
37MP0002166_altered_tumor_susceptibility1.10021982
38MP0003045_fibrosis1.08973352
39* MP0002177_abnormal_outer_ear1.08498437
40MP0002098_abnormal_vibrissa_morphology1.08153808
41MP0001191_abnormal_skin_condition1.07431985
42MP0005377_hearing/vestibular/ear_phenot1.04045538
43MP0003878_abnormal_ear_physiology1.04045538
44MP0005508_abnormal_skeleton_morphology1.03668093
45MP0004272_abnormal_basement_membrane1.03662799
46MP0001177_atelectasis1.02559165
47MP0004381_abnormal_hair_follicle1.01943060
48MP0002009_preneoplasia0.94982463
49MP0000762_abnormal_tongue_morphology0.94512112
50MP0001984_abnormal_olfaction0.93577339
51MP0004885_abnormal_endolymph0.92732268
52MP0000465_gastrointestinal_hemorrhage0.90450048
53MP0002896_abnormal_bone_mineralization0.88202660
54MP0000566_synostosis0.87955878
55MP0009780_abnormal_chondrocyte_physiolo0.87578294
56MP0000013_abnormal_adipose_tissue0.87342352
57MP0001849_ear_inflammation0.83991754
58MP0001299_abnormal_eye_distance/0.82708152
59MP0004145_abnormal_muscle_electrophysio0.81776435
60MP0002295_abnormal_pulmonary_circulatio0.81265948
61MP0004134_abnormal_chest_morphology0.80978107
62MP0001188_hyperpigmentation0.78832875
63MP0005409_darkened_coat_color0.78792060
64MP0002133_abnormal_respiratory_system0.78767057
65MP0005388_respiratory_system_phenotype0.78767057
66MP0009333_abnormal_splenocyte_physiolog0.78236506
67MP0004859_abnormal_synaptic_plasticity0.76767208
68MP0010030_abnormal_orbit_morphology0.75328211
69MP0000372_irregular_coat_pigmentation0.74781050
70MP0003763_abnormal_thymus_physiology0.73703657
71MP0009384_cardiac_valve_regurgitation0.72234098
72MP0001186_pigmentation_phenotype0.68465105
73MP0002168_other_aberrant_phenotype0.67640835
74MP0001851_eye_inflammation0.67620274
75MP0002877_abnormal_melanocyte_morpholog0.66484158
76MP0005023_abnormal_wound_healing0.62766431
77MP0004185_abnormal_adipocyte_glucose0.62258398
78MP0000462_abnormal_digestive_system0.62029315
79MP0003300_gastrointestinal_ulcer0.60863301
80MP0002282_abnormal_trachea_morphology0.60724256
81MP0000367_abnormal_coat/_hair0.60435488
82MP0000747_muscle_weakness0.59742815
83MP0001542_abnormal_bone_strength0.59500236
84MP0005647_abnormal_sex_gland0.58879062
85MP0005076_abnormal_cell_differentiation0.58826312
86MP0000432_abnormal_head_morphology0.53979925
87MP0000428_abnormal_craniofacial_morphol0.53902847
88MP0009250_abnormal_appendicular_skeleto0.53356785
89MP0005451_abnormal_body_composition0.52704632
90MP0010352_gastrointestinal_tract_polyps0.52147387
91MP0001784_abnormal_fluid_regulation0.51069260
92MP0000538_abnormal_urinary_bladder0.50082858
93MP0001346_abnormal_lacrimal_gland0.48362965
94MP0000467_abnormal_esophagus_morphology0.48036974
95MP0001340_abnormal_eyelid_morphology0.47072652
96MP0003115_abnormal_respiratory_system0.46349838
97MP0003638_abnormal_response/metabolism_0.46256528
98MP0003448_altered_tumor_morphology0.46010579
99MP0002111_abnormal_tail_morphology0.45143144
100MP0009053_abnormal_anal_canal0.44883178
101MP0003091_abnormal_cell_migration0.44351280
102MP0005390_skeleton_phenotype0.42414184
103MP0000371_diluted_coat_color0.41538142
104MP0003385_abnormal_body_wall0.39859056
105MP0004858_abnormal_nervous_system0.39413329
106MP0002928_abnormal_bile_duct0.39177250
107MP0005408_hypopigmentation0.38930407
108* MP0000015_abnormal_ear_pigmentation0.38557371
109MP0000569_abnormal_digit_pigmentation0.38438213
110MP0002115_abnormal_skeleton_extremities0.38296692
111MP0002075_abnormal_coat/hair_pigmentati0.37268447
112MP0002234_abnormal_pharynx_morphology0.36359161
113MP0003283_abnormal_digestive_organ0.36100704
114MP0000003_abnormal_adipose_tissue0.34890476
115MP0008569_lethality_at_weaning0.34602491
116MP0002233_abnormal_nose_morphology0.34563848
117MP0002089_abnormal_postnatal_growth/wei0.34492377
118MP0004782_abnormal_surfactant_physiolog0.34360891
119MP0002998_abnormal_bone_remodeling0.34130446
120MP0000627_abnormal_mammary_gland0.33152074
121MP0008789_abnormal_olfactory_epithelium0.33036361
122MP0003632_abnormal_nervous_system0.32503717
123MP0003935_abnormal_craniofacial_develop0.32136620
124MP0005499_abnormal_olfactory_system0.30706657
125MP0005394_taste/olfaction_phenotype0.30706657
126MP0005248_abnormal_Harderian_gland0.27359298
127MP0000685_abnormal_immune_system0.26608344
128MP0003136_yellow_coat_color0.21700842
129MP0005197_abnormal_uvea_morphology0.21625708
130MP0004264_abnormal_extraembryonic_tissu0.21002754
131MP0002249_abnormal_larynx_morphology0.17212916
132* MP0005174_abnormal_tail_pigmentation0.16393603
133MP0005193_abnormal_anterior_eye0.16367491
134MP0003755_abnormal_palate_morphology0.15504181
135MP0004019_abnormal_vitamin_homeostasis0.14541177
136MP0006138_congestive_heart_failure0.14365152

Predicted human phenotypes

RankGene SetZ-score
1Erythroderma (HP:0001019)8.92471104
2Atrophic scars (HP:0001075)7.95585009
3Erythema (HP:0010783)7.45829394
4Fragile skin (HP:0001030)7.42330368
5Alopecia of scalp (HP:0002293)6.74185863
6Eczematoid dermatitis (HP:0000976)6.29505036
7Premature rupture of membranes (HP:0001788)6.23753995
8Ankle contracture (HP:0006466)6.22828921
9Follicular hyperkeratosis (HP:0007502)6.15085215
10Hamartoma of the eye (HP:0010568)6.01348841
11Abnormality of the axillary hair (HP:0100134)5.94004355
12Abnormality of secondary sexual hair (HP:0009888)5.94004355
13Cerebral aneurysm (HP:0004944)5.88751531
14Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.78735070
15Abnormality of nail color (HP:0100643)5.64810492
16Soft skin (HP:0000977)5.63432278
17Protrusio acetabuli (HP:0003179)5.54969759
18Increased connective tissue (HP:0009025)5.51173799
19Aortic dissection (HP:0002647)5.49400755
20Type 1 muscle fiber predominance (HP:0003803)5.24757718
21Slender build (HP:0001533)5.05578638
22* Congenital ichthyosiform erythroderma (HP:0007431)4.88596150
23Mitral valve prolapse (HP:0001634)4.87879629
24Striae distensae (HP:0001065)4.66449936
25Dilatation of the ascending aorta (HP:0005111)4.50620759
26Fragile nails (HP:0001808)4.50254315
27Osteolytic defects of the hand bones (HP:0009699)4.37515949
28Osteolytic defects of the phalanges of the hand (HP:0009771)4.37515949
29Bladder diverticulum (HP:0000015)4.35407696
30Peritonitis (HP:0002586)3.95891050
31Broad metatarsal (HP:0001783)3.93418175
32* Palmoplantar keratoderma (HP:0000982)3.90836973
33Renovascular hypertension (HP:0100817)3.80246306
34Gastrointestinal infarctions (HP:0005244)3.77198806
35Parakeratosis (HP:0001036)3.67869034
36* Abnormal blistering of the skin (HP:0008066)3.56679621
37Hyperextensible skin (HP:0000974)3.54983487
38Mildly elevated creatine phosphokinase (HP:0008180)3.50767472
39Increased variability in muscle fiber diameter (HP:0003557)3.41219548
40Gangrene (HP:0100758)3.40337008
41Genu recurvatum (HP:0002816)3.36226712
42Hamartoma (HP:0010566)3.30091219
43Sparse eyelashes (HP:0000653)3.30073565
44Sparse scalp hair (HP:0002209)3.26263862
45Venous insufficiency (HP:0005293)3.25489651
46Milia (HP:0001056)3.24051021
47Right ventricular cardiomyopathy (HP:0011663)3.22903511
48Abnormality of the salivary glands (HP:0010286)3.21123877
49Absent eyelashes (HP:0000561)3.18190328
50Spinal rigidity (HP:0003306)3.14924666
51Melanocytic nevus (HP:0000995)3.10939256
52Narrow nasal bridge (HP:0000446)3.05739790
53Hypotrichosis (HP:0001006)3.05602692
54Abnormality of hair growth rate (HP:0011363)3.00497288
55Slow-growing hair (HP:0002217)3.00497288
56Shallow orbits (HP:0000586)2.98572583
57Woolly hair (HP:0002224)2.96441523
58Venous abnormality (HP:0002624)2.93115742
59Neonatal short-limb short stature (HP:0008921)2.92023062
60Aplasia involving bones of the extremities (HP:0009825)2.88274827
61Aplasia involving bones of the upper limbs (HP:0009823)2.88274827
62Aplasia of the phalanges of the hand (HP:0009802)2.88274827
63Abnormality of skeletal muscle fiber size (HP:0012084)2.86798913
64Hypohidrosis (HP:0000966)2.83325953
65Pili torti (HP:0003777)2.81766738
66Lack of skin elasticity (HP:0100679)2.74586288
67Periodontitis (HP:0000704)2.72924167
68Joint laxity (HP:0001388)2.70234855
69Blue sclerae (HP:0000592)2.70054297
70Lip pit (HP:0100267)2.67142216
71Hypergammaglobulinemia (HP:0010702)2.60937036
72Infantile muscular hypotonia (HP:0008947)2.59035163
73Osteoarthritis (HP:0002758)2.58643391
74Abnormality of permanent molar morphology (HP:0011071)2.55224925
75Abnormality of the dental root (HP:0006486)2.55224925
76Taurodontia (HP:0000679)2.55224925
77Nasolacrimal duct obstruction (HP:0000579)2.54395892
78Natal tooth (HP:0000695)2.46435751
79Selective tooth agenesis (HP:0001592)2.45945645
80Plantar hyperkeratosis (HP:0007556)2.44696654
81Split foot (HP:0001839)2.44110752
82Bowel diverticulosis (HP:0005222)2.43734740
83Absent hair (HP:0002298)2.42664786
84Ridged nail (HP:0001807)2.42574017
85Conical tooth (HP:0000698)2.40745235
86Abnormality of molar (HP:0011077)2.40262791
87Abnormality of molar morphology (HP:0011070)2.40262791
88Muscle fiber splitting (HP:0003555)2.39362182
89Trismus (HP:0000211)2.33797292
90Hypoplastic labia majora (HP:0000059)2.32321242
91Increased corneal curvature (HP:0100692)2.31667773
92Keratoconus (HP:0000563)2.31667773
93Pruritus (HP:0000989)2.29754046
94* Thin skin (HP:0000963)2.29644449
95Brittle hair (HP:0002299)2.29090154
96Hypoventilation (HP:0002791)2.28913362
97Abnormality of the dental pulp (HP:0006479)2.25347864
98Gingivitis (HP:0000230)2.23889645
99Blepharitis (HP:0000498)2.22563459
100Wormian bones (HP:0002645)2.21245893
101Ectropion (HP:0000656)2.21005290
102Dry hair (HP:0011359)2.20551753
103Xerostomia (HP:0000217)2.18505881
104Mitral stenosis (HP:0001718)2.15569329
105Ankyloglossia (HP:0010296)2.11229721
106Abnormality of the labia majora (HP:0012881)2.10869945
107Septate vagina (HP:0001153)2.10494049
108Nail dystrophy (HP:0008404)2.09739579
109Ectopia lentis (HP:0001083)2.09694208
110Acanthosis nigricans (HP:0000956)2.07696848
111Palmoplantar hyperkeratosis (HP:0000972)2.07364950
112Acrocyanosis (HP:0001063)2.06952851
113Premature loss of primary teeth (HP:0006323)2.06307158
114Torticollis (HP:0000473)2.05406475
115Neonatal death (HP:0003811)2.04538766
116Wide anterior fontanel (HP:0000260)2.02686191
117Sensory axonal neuropathy (HP:0003390)2.02627498
118Abnormality of the lacrimal duct (HP:0011481)2.00600743
119Gingival overgrowth (HP:0000212)2.00065410
120Increased IgE level (HP:0003212)1.98750328
121Oral leukoplakia (HP:0002745)1.98500110
122Limb-girdle muscle weakness (HP:0003325)1.97519089
123Elbow flexion contracture (HP:0002987)1.96723726
124Generalized amyotrophy (HP:0003700)1.96263530
125Duplicated collecting system (HP:0000081)1.96221837
126Abnormal delivery (HP:0001787)1.96135834
127Disproportionate tall stature (HP:0001519)1.95389502
128Depressed nasal tip (HP:0000437)1.94794884
129Palmar hyperkeratosis (HP:0010765)1.94162614
130Biconcave vertebral bodies (HP:0004586)1.93607603
131Hyperhidrosis (HP:0000975)1.92711227
132Hyporeflexia of lower limbs (HP:0002600)1.91590585
133Mitral regurgitation (HP:0001653)1.90891141
134Skin ulcer (HP:0200042)1.88327434
135Aneurysm (HP:0002617)1.84897046
136Achilles tendon contracture (HP:0001771)1.83156306
137Morphological abnormality of the middle ear (HP:0008609)1.82056731
138Abnormal hair laboratory examination (HP:0003328)1.80977135
139Advanced eruption of teeth (HP:0006288)1.80939338
140Protruding ear (HP:0000411)1.79901825
141Ventricular tachycardia (HP:0004756)1.79480185
142Overgrowth (HP:0001548)1.78316402
143Onycholysis (HP:0001806)1.77305186
144Abnormality of the nasolacrimal system (HP:0000614)1.77123910
145Abnormality of the Achilles tendon (HP:0005109)1.74816458
146Curly hair (HP:0002212)1.73634741
147Corneal erosion (HP:0200020)1.73465971
148Abnormality of the peritoneum (HP:0002585)1.72947418
149Conjunctival hamartoma (HP:0100780)1.72653471
150Thick nail (HP:0001805)1.70387681
151Hip contracture (HP:0003273)1.70347807
152Hallux valgus (HP:0001822)1.68851025
153Nonimmune hydrops fetalis (HP:0001790)1.67950182
154Aortic regurgitation (HP:0001659)1.67417101
155Oligodontia (HP:0000677)1.66353716
156Aortic aneurysm (HP:0004942)1.65898547
157Abnormality of the renal collecting system (HP:0004742)1.65600970
158Deviation of the hallux (HP:0010051)1.65218622
159Abnormality of oral frenula (HP:0000190)1.64841713
160Craniofacial dystonia (HP:0012179)1.63508529
161Spondylolisthesis (HP:0003302)1.62589758
162Thin bony cortex (HP:0002753)1.62300834
163Fine hair (HP:0002213)1.60958024
164Ventricular fibrillation (HP:0001663)1.55474431
165Abnormality of the neuromuscular junction (HP:0003398)1.54131888
166Fatigable weakness (HP:0003473)1.54131888
167Breast hypoplasia (HP:0003187)1.49873683
168Verrucae (HP:0200043)1.48519149
169Papilloma (HP:0012740)1.48519149
170Dry skin (HP:0000958)1.45967508
171Coronal craniosynostosis (HP:0004440)1.43512514
172Coarse hair (HP:0002208)1.41034668
173Alacrima (HP:0000522)1.39649076
174Furrowed tongue (HP:0000221)1.38796019
175Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.38329331
176Abnormality of incisor morphology (HP:0011063)1.36187268
177Blue irides (HP:0000635)1.35887011
178Anonychia (HP:0001798)1.32415337
179Laryngomalacia (HP:0001601)1.32268720

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR15.77599548
2TGFBR15.00227286
3STK244.59286238
4FGFR24.34088146
5MAP3K64.30877488
6LATS13.32456777
7FER2.89081113
8EPHA32.77432957
9PDGFRA2.65855864
10NTRK22.38453519
11SIK12.31001272
12RPS6KB22.21150692
13DDR22.12614415
14PRPF4B2.01496159
15MST1R2.00606857
16TGFBR21.99983387
17FRK1.99482781
18RIPK11.93780226
19TTN1.86801615
20PRKCH1.78021497
21MAP3K91.76618661
22LATS21.64538196
23BCR1.63664434
24FGFR31.61009408
25OBSCN1.55300398
26TRIB31.44194960
27CAMK1G1.38625575
28MAP3K21.35674212
29CAMK1D1.35406199
30PDGFRB1.33780961
31MET1.28172182
32MAP3K71.26896355
33MAP2K61.25230891
34MAP3K31.20140548
35EEF2K1.17824108
36NTRK31.16317681
37RPS6KB11.14350958
38NTRK11.11983027
39EPHA41.11108568
40DAPK21.04269078
41SCYL21.04057147
42FGFR41.02928908
43KIT1.01623695
44MAP2K41.00236715
45PTK60.98501485
46PKN20.98003283
47CSNK1A1L0.97468436
48RET0.96218453
49EPHB10.96112038
50SGK2230.95950006
51SGK4940.95950006
52BMX0.95350500
53TRPM70.93813716
54NLK0.93757630
55MAP3K10.89872999
56ERN10.88311643
57STK380.85345504
58MAPKAPK20.84052867
59MARK20.84052187
60CDK120.81558159
61PAK60.81288926
62CAMKK10.81176979
63JAK10.78916438
64TYRO30.78160275
65PTK20.77901667
66SGK20.75681682
67UHMK10.75145665
68PRKAA20.73188482
69SMG10.72955174
70FGR0.70716022
71IKBKB0.70193231
72RIPK40.68853901
73MAPKAPK50.68389210
74WNK10.66799052
75PKN10.65979782
76MAPK110.65548480
77ALK0.63912772
78CDK50.63868328
79SRC0.62526921
80PAK20.62068084
81MTOR0.61861250
82RPS6KA20.60672563
83PBK0.58564403
84MAPK120.58264862
85MAP3K100.56497072
86PAK30.53513808
87ERBB20.52813671
88STK110.52734208
89MAPK130.52318695
90IRAK10.52150476
91CAMK40.51460976
92PRKD20.51222215
93FYN0.51183323
94ROCK20.50514593
95LRRK20.50113046
96PIK3CG0.49908847
97GRK60.49823093
98MAPK70.49556102
99PRKD10.48992996
100CDK60.48545759
101EPHA20.48024564
102STK30.47982424
103EPHB20.47087184
104ADRBK10.43512004
105PRKCE0.42271097
106ERBB40.41364540
107CDC42BPA0.41165817
108CDK30.40048850
109ILK0.40009222
110DMPK0.38931777
111GSK3A0.38430340
112MINK10.38191059
113SGK10.37822734
114MAPKAPK30.35452604
115ROCK10.35444892
116ITK0.35173510
117HCK0.33590992
118FES0.32829346
119CSNK1D0.32712841
120MAPK90.32181266
121PTK2B0.32030530
122MARK10.31779991
123TAF10.30686128
124JAK20.29887768
125HIPK20.29114311
126ABL10.28885048
127STK38L0.28742052
128PRKD30.28377714
129LMTK20.28222319
130EGFR0.28188004
131KSR20.27724744
132SGK30.27402159
133PHKG20.27345532
134PHKG10.27345532
135DYRK1B0.27318847
136TAOK10.27192193
137ICK0.27104985
138MYLK0.25211454
139BRD40.24879858
140CDK70.22560375
141TESK10.19601939
142ABL20.17359000
143IGF1R0.15497096
144MOS0.14041465
145MAPK40.11651532
146MAPK80.10742879
147JAK30.10267909
148MAPK30.09915516

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005925.98535910
2Protein digestion and absorption_Homo sapiens_hsa049744.57099303
3ECM-receptor interaction_Homo sapiens_hsa045124.21855002
4Linoleic acid metabolism_Homo sapiens_hsa005914.13417375
5Histidine metabolism_Homo sapiens_hsa003403.04782157
6Ether lipid metabolism_Homo sapiens_hsa005653.02902409
7Arachidonic acid metabolism_Homo sapiens_hsa005902.87159669
8Sphingolipid metabolism_Homo sapiens_hsa006002.65802865
9Amoebiasis_Homo sapiens_hsa051462.39097434
10Focal adhesion_Homo sapiens_hsa045102.15773175
11Vitamin digestion and absorption_Homo sapiens_hsa049772.02564236
12Nitrogen metabolism_Homo sapiens_hsa009101.99933287
13Phototransduction_Homo sapiens_hsa047441.97121448
14AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.79808804
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.72122743
16Platelet activation_Homo sapiens_hsa046111.69593823
17Ovarian steroidogenesis_Homo sapiens_hsa049131.62701218
18Circadian rhythm_Homo sapiens_hsa047101.52912595
19Dorso-ventral axis formation_Homo sapiens_hsa043201.50283937
20Proteoglycans in cancer_Homo sapiens_hsa052051.48032314
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.47680466
22ABC transporters_Homo sapiens_hsa020101.46354097
23GnRH signaling pathway_Homo sapiens_hsa049121.45226943
24Long-term potentiation_Homo sapiens_hsa047201.38743913
25Renin secretion_Homo sapiens_hsa049241.35986595
26Retinol metabolism_Homo sapiens_hsa008301.34845878
27Axon guidance_Homo sapiens_hsa043601.34046561
28Phenylalanine metabolism_Homo sapiens_hsa003601.24067837
29Glioma_Homo sapiens_hsa052141.23804226
30Glycerophospholipid metabolism_Homo sapiens_hsa005641.21915075
31Dilated cardiomyopathy_Homo sapiens_hsa054141.20863605
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.18319074
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17687647
34Gastric acid secretion_Homo sapiens_hsa049711.16829356
35beta-Alanine metabolism_Homo sapiens_hsa004101.15704250
36Salivary secretion_Homo sapiens_hsa049701.15073441
37Adherens junction_Homo sapiens_hsa045201.12258128
38MicroRNAs in cancer_Homo sapiens_hsa052061.11111339
39Cyanoamino acid metabolism_Homo sapiens_hsa004601.09999647
40Long-term depression_Homo sapiens_hsa047301.07509557
41Circadian entrainment_Homo sapiens_hsa047131.05436760
42Estrogen signaling pathway_Homo sapiens_hsa049151.04906261
43Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.04728403
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03831230
45Melanogenesis_Homo sapiens_hsa049161.03391705
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02897296
47Primary bile acid biosynthesis_Homo sapiens_hsa001200.98545546
48Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.98176187
49Sphingolipid signaling pathway_Homo sapiens_hsa040710.97584556
50Glutamatergic synapse_Homo sapiens_hsa047240.95721471
51Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.94006493
52PI3K-Akt signaling pathway_Homo sapiens_hsa041510.93492658
53Type II diabetes mellitus_Homo sapiens_hsa049300.93478127
54Tyrosine metabolism_Homo sapiens_hsa003500.93171726
55Fatty acid elongation_Homo sapiens_hsa000620.91444619
56Fatty acid biosynthesis_Homo sapiens_hsa000610.90161085
57Arginine biosynthesis_Homo sapiens_hsa002200.89096453
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88172833
59Oxytocin signaling pathway_Homo sapiens_hsa049210.86336631
60Thyroid cancer_Homo sapiens_hsa052160.85839186
61Bile secretion_Homo sapiens_hsa049760.85795639
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.82247946
63Gap junction_Homo sapiens_hsa045400.82022781
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.80943420
65Small cell lung cancer_Homo sapiens_hsa052220.78597693
66Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.78338695
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77964698
68Cholinergic synapse_Homo sapiens_hsa047250.77100884
69Lysine degradation_Homo sapiens_hsa003100.76634346
70Regulation of actin cytoskeleton_Homo sapiens_hsa048100.75973812
71Notch signaling pathway_Homo sapiens_hsa043300.75017114
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74970611
73Dopaminergic synapse_Homo sapiens_hsa047280.74169861
74Rap1 signaling pathway_Homo sapiens_hsa040150.73238248
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73009407
76Calcium signaling pathway_Homo sapiens_hsa040200.72750869
77Pertussis_Homo sapiens_hsa051330.72323706
78Insulin secretion_Homo sapiens_hsa049110.70788901
79Acute myeloid leukemia_Homo sapiens_hsa052210.69290633
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.68395423
81Glucagon signaling pathway_Homo sapiens_hsa049220.67971985
82ErbB signaling pathway_Homo sapiens_hsa040120.67641917
83VEGF signaling pathway_Homo sapiens_hsa043700.67355026
84Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67176856
85Insulin resistance_Homo sapiens_hsa049310.66482520
86Pancreatic secretion_Homo sapiens_hsa049720.65498161
87Fatty acid metabolism_Homo sapiens_hsa012120.65496056
88Hippo signaling pathway_Homo sapiens_hsa043900.65030720
89Complement and coagulation cascades_Homo sapiens_hsa046100.64896989
90Basal cell carcinoma_Homo sapiens_hsa052170.64351116
91PPAR signaling pathway_Homo sapiens_hsa033200.64080971
92Hedgehog signaling pathway_Homo sapiens_hsa043400.62544785
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62166921
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61156558
95Ras signaling pathway_Homo sapiens_hsa040140.60236849
96GABAergic synapse_Homo sapiens_hsa047270.60159736
97cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60068107
98Staphylococcus aureus infection_Homo sapiens_hsa051500.59660658
99Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.59004845
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.58248821
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57807129
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.57413916
103Fatty acid degradation_Homo sapiens_hsa000710.57184481
104cAMP signaling pathway_Homo sapiens_hsa040240.56925787
105Endometrial cancer_Homo sapiens_hsa052130.56837416
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56415096
107Inositol phosphate metabolism_Homo sapiens_hsa005620.55773924
108Malaria_Homo sapiens_hsa051440.55768871
109Amphetamine addiction_Homo sapiens_hsa050310.55490413
110Wnt signaling pathway_Homo sapiens_hsa043100.55409050
111Glycerolipid metabolism_Homo sapiens_hsa005610.53766320
112Toxoplasmosis_Homo sapiens_hsa051450.53695114
113Thyroid hormone synthesis_Homo sapiens_hsa049180.52239870
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.51752559
115Olfactory transduction_Homo sapiens_hsa047400.51440322
116Prostate cancer_Homo sapiens_hsa052150.51419518
117Bladder cancer_Homo sapiens_hsa052190.50835777
118Steroid biosynthesis_Homo sapiens_hsa001000.50321141
119Fat digestion and absorption_Homo sapiens_hsa049750.49985775
120Non-small cell lung cancer_Homo sapiens_hsa052230.49934781
121Renal cell carcinoma_Homo sapiens_hsa052110.49639280
122Choline metabolism in cancer_Homo sapiens_hsa052310.49127637
123Serotonergic synapse_Homo sapiens_hsa047260.49008136
124Endocytosis_Homo sapiens_hsa041440.48795224
125Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48769800
126Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48243970
127Butanoate metabolism_Homo sapiens_hsa006500.48180740
128Chronic myeloid leukemia_Homo sapiens_hsa052200.46655484
129Tight junction_Homo sapiens_hsa045300.46606220
130Pathways in cancer_Homo sapiens_hsa052000.44820085
131mTOR signaling pathway_Homo sapiens_hsa041500.44781140
132Hepatitis C_Homo sapiens_hsa051600.42734025
133p53 signaling pathway_Homo sapiens_hsa041150.42045451
134Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41250676
135Tuberculosis_Homo sapiens_hsa051520.40950540
136Insulin signaling pathway_Homo sapiens_hsa049100.39197790
137Adipocytokine signaling pathway_Homo sapiens_hsa049200.36985964
138MAPK signaling pathway_Homo sapiens_hsa040100.32680886
139Lysosome_Homo sapiens_hsa041420.31139297
140Renin-angiotensin system_Homo sapiens_hsa046140.24500503

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