KRT15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region on chromosome 17q21.2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of tissue polarity (GO:0007164)7.49603594
2establishment of planar polarity (GO:0001736)7.49603594
3establishment of skin barrier (GO:0061436)6.75743597
4keratinocyte proliferation (GO:0043616)6.70458895
5regulation of water loss via skin (GO:0033561)6.36314415
6ribosomal small subunit biogenesis (GO:0042274)6.31543550
7viral transcription (GO:0019083)6.18587513
8polarized epithelial cell differentiation (GO:0030859)6.17117595
9translational termination (GO:0006415)5.76759002
10epithelial cell differentiation involved in prostate gland development (GO:0060742)5.63183256
11keratinization (GO:0031424)5.36947294
12mitotic G1 DNA damage checkpoint (GO:0031571)5.11822155
13peptide cross-linking (GO:0018149)4.91376644
14multicellular organismal water homeostasis (GO:0050891)4.77653610
15heart valve formation (GO:0003188)4.77391229
16regulation of phospholipase A2 activity (GO:0032429)4.75623976
17planar cell polarity pathway involved in neural tube closure (GO:0090179)4.74124346
18mitotic G1/S transition checkpoint (GO:0044819)4.67663033
19heart valve morphogenesis (GO:0003179)4.65549792
20G1 DNA damage checkpoint (GO:0044783)4.60351288
21bundle of His cell to Purkinje myocyte communication (GO:0086069)4.54421323
22ribosomal small subunit assembly (GO:0000028)4.53752818
23SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.52158930
24keratinocyte differentiation (GO:0030216)4.50377678
25translational elongation (GO:0006414)4.48024529
26G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.46596249
27viral life cycle (GO:0019058)4.46590109
28protein targeting to ER (GO:0045047)4.45057598
29cotranslational protein targeting to membrane (GO:0006613)4.42036767
30maturation of SSU-rRNA (GO:0030490)4.41637734
31cellular protein complex disassembly (GO:0043624)4.40995169
32* epidermis development (GO:0008544)4.36645161
33fusion of sperm to egg plasma membrane (GO:0007342)4.33995814
34establishment of protein localization to endoplasmic reticulum (GO:0072599)4.30504282
35regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.21680497
36acrosome reaction (GO:0007340)4.19604805
37negative regulation of keratinocyte proliferation (GO:0010839)4.12242892
38protein localization to endoplasmic reticulum (GO:0070972)4.10176920
39genitalia morphogenesis (GO:0035112)4.06250369
40water homeostasis (GO:0030104)4.03404159
41nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.03342898
42positive regulation of gastrulation (GO:2000543)4.01123424
43epidermal cell differentiation (GO:0009913)3.99354507
44regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.90406118
45positive regulation of epidermal cell differentiation (GO:0045606)3.89487539
46ectoderm development (GO:0007398)3.88479255
47negative regulation of cell fate commitment (GO:0010454)3.86701188
48keratinocyte development (GO:0003334)3.86273352
49hair cycle (GO:0042633)3.84823676
50molting cycle (GO:0042303)3.84823676
51lateral sprouting from an epithelium (GO:0060601)3.77599973
52limb bud formation (GO:0060174)3.74870677
53negative regulation of T cell mediated immunity (GO:0002710)3.74290007
54cell-substrate junction assembly (GO:0007044)3.74024757
55atrioventricular valve morphogenesis (GO:0003181)3.67390067
56protein complex disassembly (GO:0043241)3.63585084
57epithelial cell-cell adhesion (GO:0090136)3.59896190
58regulation of ruffle assembly (GO:1900027)3.56709214
59intermediate filament organization (GO:0045109)3.55523003
60morphogenesis of embryonic epithelium (GO:0016331)3.52626064
61positive regulation of odontogenesis (GO:0042482)3.51829465
62intermediate filament cytoskeleton organization (GO:0045104)3.48086971
63ribosomal large subunit biogenesis (GO:0042273)3.45991845
64face development (GO:0060324)3.44889288
65non-canonical Wnt signaling pathway (GO:0035567)3.43535352
66regulation of cell proliferation involved in kidney development (GO:1901722)3.42947512
67sphingoid metabolic process (GO:0046519)3.41376230
68axonemal dynein complex assembly (GO:0070286)3.40202868
69endothelial cell chemotaxis (GO:0035767)3.39611115
70regulation of endothelial cell chemotaxis (GO:2001026)3.38680876
71positive regulation of epidermis development (GO:0045684)3.37828000
72intermediate filament-based process (GO:0045103)3.34476858
73skin morphogenesis (GO:0043589)3.33478805
74negative regulation of cell fate specification (GO:0009996)3.31861670
75protein targeting to membrane (GO:0006612)3.28948766
76sperm motility (GO:0030317)3.28439990
77epithelial cell fate commitment (GO:0072148)3.26078454
78macromolecular complex disassembly (GO:0032984)3.26048798
79negative regulation of epidermis development (GO:0045683)3.25697849
80glucosamine-containing compound catabolic process (GO:1901072)3.25546247
81translational initiation (GO:0006413)3.23137655
82hair cycle process (GO:0022405)3.21442169
83molting cycle process (GO:0022404)3.21442169
84intestinal epithelial cell development (GO:0060576)3.18457516
85positive regulation of Cdc42 GTPase activity (GO:0043089)3.18398840
86response to BMP (GO:0071772)3.14803961
87cellular response to BMP stimulus (GO:0071773)3.14803961
88embryonic viscerocranium morphogenesis (GO:0048703)3.14047858
89regulation of epidermis development (GO:0045682)3.11403045
90sexual reproduction (GO:0019953)3.10564307
91positive regulation of keratinocyte differentiation (GO:0045618)3.10436386
92eyelid development in camera-type eye (GO:0061029)3.09276783
93positive regulation of vesicle fusion (GO:0031340)3.09244577
94plasma membrane fusion (GO:0045026)3.08712576
95cellular response to vitamin D (GO:0071305)3.08334974
96regulation of cardioblast differentiation (GO:0051890)3.07707681
97mesenchymal to epithelial transition (GO:0060231)3.07149862
98regulation of keratinocyte proliferation (GO:0010837)3.06254756
99negative regulation of stress fiber assembly (GO:0051497)3.05806109
100regulation of epidermal cell differentiation (GO:0045604)3.04076601
101sperm capacitation (GO:0048240)3.03351619
102interferon-gamma secretion (GO:0072643)3.02659250
103regulation of establishment of planar polarity (GO:0090175)3.02210817
104ventricular cardiac muscle cell action potential (GO:0086005)3.00339711
105regulation of glucocorticoid metabolic process (GO:0031943)2.98771639
106regulation of keratinocyte differentiation (GO:0045616)2.98225565
107embryonic camera-type eye development (GO:0031076)2.98174710
108endosome organization (GO:0007032)2.96909693
109cytoskeletal anchoring at plasma membrane (GO:0007016)2.96488613
110endocardial cushion morphogenesis (GO:0003203)2.96172129
111sympathetic nervous system development (GO:0048485)2.93583483
112DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.93493893
113cardiac right ventricle morphogenesis (GO:0003215)2.92525717
114odontogenesis (GO:0042476)2.91327027
115surfactant homeostasis (GO:0043129)2.89394265
116regulation of Cdc42 GTPase activity (GO:0043088)2.88906400
117regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.87925577
118negative regulation of osteoblast proliferation (GO:0033689)2.87901805
119odontogenesis of dentin-containing tooth (GO:0042475)2.87523576
120neural crest cell development (GO:0014032)2.87047406
121dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.85969530
122hair follicle morphogenesis (GO:0031069)2.85933872
123digestive tract morphogenesis (GO:0048546)2.83502107
124positive regulation of cartilage development (GO:0061036)2.83171332
125negative regulation of catenin import into nucleus (GO:0035414)2.81606924
126hypotonic response (GO:0006971)2.80989404
127* epithelium development (GO:0060429)2.80546926
128lymph vessel development (GO:0001945)2.79589647
129establishment of apical/basal cell polarity (GO:0035089)2.77992023
130membrane budding (GO:0006900)2.77644796
131semaphorin-plexin signaling pathway (GO:0071526)2.77441775
132gland morphogenesis (GO:0022612)2.77129461
133positive regulation of cardiac muscle cell differentiation (GO:2000727)2.77070374
134cochlea morphogenesis (GO:0090103)2.73129206
135ephrin receptor signaling pathway (GO:0048013)2.73125436
136sphingosine metabolic process (GO:0006670)2.71692772
137regulation of male gonad development (GO:2000018)2.71546300
138motile cilium assembly (GO:0044458)2.71501789
139regulation of hormone metabolic process (GO:0032350)2.71290181
140negative regulation of epidermal cell differentiation (GO:0045605)2.71071972
141Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.70987852
142chromosome condensation (GO:0030261)2.70375548
143negative regulation of kidney development (GO:0090185)2.69065935
144one-carbon compound transport (GO:0019755)2.69038165
145oocyte development (GO:0048599)2.68490645
146negative regulation of inclusion body assembly (GO:0090084)2.65865622
147morphogenesis of an epithelial fold (GO:0060571)2.65746981
148establishment of epithelial cell polarity (GO:0090162)2.64523914
149DNA packaging (GO:0006323)2.62947599
150lung-associated mesenchyme development (GO:0060484)2.62512016
151smooth muscle tissue development (GO:0048745)2.62410233
152hair follicle development (GO:0001942)2.62354385
153negative regulation of actin filament bundle assembly (GO:0032232)2.61908414
154lung epithelium development (GO:0060428)2.61762426
155negative regulation of interleukin-2 production (GO:0032703)2.61701555
156mesenchyme morphogenesis (GO:0072132)2.60484468
157response to vitamin D (GO:0033280)2.60176154
158cellular response to vitamin (GO:0071295)2.60106185
159cardiac epithelial to mesenchymal transition (GO:0060317)2.59545682
160otic vesicle formation (GO:0030916)2.59216315
161positive regulation of embryonic development (GO:0040019)2.58320626
162epithelial cell proliferation (GO:0050673)2.55981939
163skin development (GO:0043588)2.55832390
164DNA damage response, signal transduction resulting in transcription (GO:0042772)2.55069584
165desmosome organization (GO:0002934)13.5102664
166hemidesmosome assembly (GO:0031581)12.2522229

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.07361031
2SOX9_24532713_ChIP-Seq_HFSC_Mouse3.76393557
3STAT6_21828071_ChIP-Seq_BEAS2B_Human3.23358878
4TRIM28_21343339_ChIP-Seq_HEK293_Human2.80076314
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.46072538
6P63_26484246_Chip-Seq_KERATINOCYTES_Human2.34644253
7ZNF263_19887448_ChIP-Seq_K562_Human2.23559816
8AR_21572438_ChIP-Seq_LNCaP_Human2.21948534
9* ESR1_21235772_ChIP-Seq_MCF-7_Human2.10315709
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.06826840
11TP63_17297297_ChIP-ChIP_HaCaT_Human13.5608469
12KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.87896497
13* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.80139141
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.76343132
15EED_16625203_ChIP-ChIP_MESCs_Mouse1.76002206
16* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.67245353
17* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.67245353
18* ESR2_21235772_ChIP-Seq_MCF-7_Human1.64202356
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.60151999
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.59925820
21SMC4_20622854_ChIP-Seq_HELA_Human1.58276742
22JARID2_20064375_ChIP-Seq_MESCs_Mouse1.56860641
23JARID2_20075857_ChIP-Seq_MESCs_Mouse1.55793383
24* TP53_20018659_ChIP-ChIP_R1E_Mouse1.53572099
25ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52179194
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.51769179
27EZH2_27304074_Chip-Seq_ESCs_Mouse1.49577970
28ATF3_27146783_Chip-Seq_COLON_Human1.48493601
29SUZ12_27294783_Chip-Seq_ESCs_Mouse1.45723547
30FOXO3_23340844_ChIP-Seq_DLD1_Human1.45670621
31RNF2_18974828_ChIP-Seq_MESCs_Mouse1.43534281
32EZH2_18974828_ChIP-Seq_MESCs_Mouse1.43534281
33SOX2_27498859_Chip-Seq_STOMACH_Mouse1.42037286
34RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37282136
35RNF2_27304074_Chip-Seq_ESCs_Mouse1.35673431
36ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.33940595
37TP53_18474530_ChIP-ChIP_U2OS_Human1.33599001
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32014502
39CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.31461126
40P68_20966046_ChIP-Seq_HELA_Human1.31351909
41EZH2_27294783_Chip-Seq_ESCs_Mouse1.31055469
42SOX2_20726797_ChIP-Seq_SW620_Human1.30606969
43SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.30491038
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.26762245
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26735953
46BCOR_27268052_Chip-Seq_Bcells_Human1.26425031
47CJUN_26792858_Chip-Seq_BT549_Human1.25706072
48ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25447489
49RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24181997
50* KLF5_25053715_ChIP-Seq_YYC3_Human1.22255816
51TP63_23658742_ChIP-Seq_EP156T_Human1.21582726
52P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.21571350
53PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.20062014
54CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.19543702
55SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.18775701
56* GATA6_25053715_ChIP-Seq_YYC3_Human1.16390588
57MTF2_20144788_ChIP-Seq_MESCs_Mouse1.14798719
58RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14127912
59BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.13816920
60RUNX1_27514584_Chip-Seq_MCF-7_Human1.13420768
61E2F1_20622854_ChIP-Seq_HELA_Human1.13365687
62TCF4_18268006_ChIP-ChIP_LS174T_Human1.11122057
63SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.10475656
64* ELK3_25401928_ChIP-Seq_HUVEC_Human1.10137560
65BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09202367
66TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08134681
67THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06488128
68GATA3_24758297_ChIP-Seq_MCF-7_Human1.05037731
69* TP63_22573176_ChIP-Seq_HFKS_Human1.04846993
70CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.03253787
71EGR1_19032775_ChIP-ChIP_M12_Human1.03115383
72KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02188500
73RBPJ_22232070_ChIP-Seq_NCS_Mouse1.01103268
74P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00129239
75RING1B_27294783_Chip-Seq_ESCs_Mouse0.99931130
76FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.99140351
77HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99077579
78AHR_22903824_ChIP-Seq_MCF-7_Human0.97999001
79GATA6_21074721_ChIP-Seq_CACO-2_Human0.97721703
80CTCF_27219007_Chip-Seq_Bcells_Human0.96208975
81NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.95744324
82CREB1_26743006_Chip-Seq_LNCaP_Human0.94807187
83SA1_27219007_Chip-Seq_Bcells_Human0.94666697
84TP53_16413492_ChIP-PET_HCT116_Human0.94278803
85KDM2B_26808549_Chip-Seq_K562_Human0.94259359
86SMAD3_21741376_ChIP-Seq_HESCs_Human0.93937409
87UBF1/2_26484160_Chip-Seq_HMECs_Human0.93404748
88STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.92409189
89CTCF_20526341_ChIP-Seq_ESCs_Human0.92374654
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.91927468
91BCL6_27268052_Chip-Seq_Bcells_Human0.91120176
92PIAS1_25552417_ChIP-Seq_VCAP_Human0.90013658
93PPAR_26484153_Chip-Seq_NCI-H1993_Human0.88747218
94YY1_22570637_ChIP-Seq_MALME-3M_Human0.88631831
95CBX2_27304074_Chip-Seq_ESCs_Mouse0.88481726
96RBPJ_21746931_ChIP-Seq_IB4_Human0.88097308
97RING1B_27294783_Chip-Seq_NPCs_Mouse0.87836327
98SRY_22984422_ChIP-ChIP_TESTIS_Rat0.87541141
99PHF8_20622854_ChIP-Seq_HELA_Human0.86393222
100CDX2_20551321_ChIP-Seq_CACO-2_Human0.86215182
101PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.86082082
102TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85496402
103TET1_21490601_ChIP-Seq_MESCs_Mouse0.85063011
104UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.83637889
105FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.83561187
106ELF1_20517297_ChIP-Seq_JURKAT_Human0.83290584
107RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.83220163
108CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.80969275
109* RACK7_27058665_Chip-Seq_MCF-7_Human0.80482873
110SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.79852294
111HNFA_21074721_ChIP-Seq_CACO-2_Human0.79830324
112JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79359814
113SA1_27219007_Chip-Seq_ERYTHROID_Human0.79133975
114KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.78709674
115TP53_22127205_ChIP-Seq_IMR90_Human0.77775600
116ETV1_20927104_ChIP-Seq_GIST48_Human0.77246549
117KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.76641875
118CLOCK_20551151_ChIP-Seq_293T_Human0.76567972
119BCAT_22108803_ChIP-Seq_LS180_Human0.75492695
120TCF7_22412390_ChIP-Seq_EML_Mouse0.74847174
121EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.74696737
122CDX2_19796622_ChIP-Seq_MESCs_Mouse0.74074278
123GATA1_19941826_ChIP-Seq_K562_Human0.74053108
124CBX2_22325352_ChIP-Seq_293T-Rex_Human0.73913104
125LXR_22292898_ChIP-Seq_THP-1_Human0.73910128
126EP300_21415370_ChIP-Seq_HL-1_Mouse0.73806377
127MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.73137520
128P300_27268052_Chip-Seq_Bcells_Human0.72985247
129RXR_22108803_ChIP-Seq_LS180_Human0.72827477
130DNAJC2_21179169_ChIP-ChIP_NT2_Human0.71946424
131FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.71859957
132WT1_19549856_ChIP-ChIP_CCG9911_Human0.71689991
133CTCF_27219007_Chip-Seq_ERYTHROID_Human0.71684001
134CEBPB_22108803_ChIP-Seq_LS180_Human0.71454779
135GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.71327944
136ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.71246965
137NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.70829943
138NRF2_20460467_ChIP-Seq_MEFs_Mouse0.70829943
139FOXM1_26456572_ChIP-Seq_MCF-7_Human0.69171082
140ARNT_22903824_ChIP-Seq_MCF-7_Human0.68238866
141ESR1_20079471_ChIP-ChIP_T-47D_Human0.67721326
142RNF2_27304074_Chip-Seq_NSC_Mouse0.66182079
143GATA4_25053715_ChIP-Seq_YYC3_Human0.65157134
144JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.64422918
145TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.64279326
146TCF4_22108803_ChIP-Seq_LS180_Human0.63325967
147IKZF1_21737484_ChIP-ChIP_HCT116_Human0.62967507
148GATA1_22025678_ChIP-Seq_K562_Human0.62551932
149KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.61099738

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle6.75205512
2MP0002796_impaired_skin_barrier5.00316125
3MP0003941_abnormal_skin_development4.36444669
4MP0005275_abnormal_skin_tensile4.16348809
5MP0004381_abnormal_hair_follicle3.90658136
6MP0002060_abnormal_skin_morphology3.78893536
7MP0000383_abnormal_hair_follicle3.72363393
8MP0010678_abnormal_skin_adnexa3.58526975
9MP0000579_abnormal_nail_morphology3.32032805
10MP0005501_abnormal_skin_physiology3.06389109
11MP0000647_abnormal_sebaceous_gland2.99114749
12MP0002098_abnormal_vibrissa_morphology2.95037300
13MP0001216_abnormal_epidermal_layer2.90719745
14MP0002254_reproductive_system_inflammat2.89882587
15MP0000762_abnormal_tongue_morphology2.68981450
16MP0010771_integument_phenotype2.56626314
17MP0000377_abnormal_hair_follicle2.52718538
18MP0003453_abnormal_keratinocyte_physiol2.39999667
19MP0001346_abnormal_lacrimal_gland2.37468307
20MP0003136_yellow_coat_color2.36222907
21MP0000427_abnormal_hair_cycle2.34039364
22MP0009379_abnormal_foot_pigmentation2.24791018
23MP0000467_abnormal_esophagus_morphology2.16879458
24MP0009780_abnormal_chondrocyte_physiolo2.03730046
25MP0002249_abnormal_larynx_morphology2.01563412
26MP0005410_abnormal_fertilization2.01059926
27MP0000566_synostosis1.87018948
28MP0003566_abnormal_cell_adhesion1.83583221
29MP0003878_abnormal_ear_physiology1.82184438
30MP0005377_hearing/vestibular/ear_phenot1.82184438
31MP0003705_abnormal_hypodermis_morpholog1.81946793
32MP0002009_preneoplasia1.81613776
33MP0010030_abnormal_orbit_morphology1.79523003
34MP0004264_abnormal_extraembryonic_tissu1.66531741
35MP0004947_skin_inflammation1.65994349
36MP0001851_eye_inflammation1.58952252
37MP0002282_abnormal_trachea_morphology1.52708312
38MP0001340_abnormal_eyelid_morphology1.51357803
39MP0001191_abnormal_skin_condition1.47676787
40MP0002277_abnormal_respiratory_mucosa1.44307565
41MP0001243_abnormal_dermal_layer1.39742734
42MP0009931_abnormal_skin_appearance1.39416764
43MP0002234_abnormal_pharynx_morphology1.33864542
44MP0001849_ear_inflammation1.31094056
45MP0004019_abnormal_vitamin_homeostasis1.29871670
46MP0005257_abnormal_intraocular_pressure1.27776527
47MP0002102_abnormal_ear_morphology1.26952705
48MP0005508_abnormal_skeleton_morphology1.26691642
49MP0003011_delayed_dark_adaptation1.24676421
50MP0000367_abnormal_coat/_hair1.22016555
51MP0001188_hyperpigmentation1.21380227
52MP0005503_abnormal_tendon_morphology1.20550401
53MP0005451_abnormal_body_composition1.20378229
54MP0000013_abnormal_adipose_tissue1.18984693
55MP0009250_abnormal_appendicular_skeleto1.18925158
56MP0004272_abnormal_basement_membrane1.15659517
57MP0000465_gastrointestinal_hemorrhage1.14865882
58MP0002132_abnormal_respiratory_system1.14102667
59MP0009384_cardiac_valve_regurgitation1.13069056
60MP0002233_abnormal_nose_morphology1.04268382
61MP0004043_abnormal_pH_regulation1.04200739
62MP0003755_abnormal_palate_morphology1.03747485
63MP0008789_abnormal_olfactory_epithelium1.02802216
64MP0000049_abnormal_middle_ear0.96510984
65MP0002177_abnormal_outer_ear0.95737546
66MP0005409_darkened_coat_color0.94579132
67MP0001919_abnormal_reproductive_system0.88592300
68MP0004185_abnormal_adipocyte_glucose0.85573154
69MP0000627_abnormal_mammary_gland0.82238855
70MP0005187_abnormal_penis_morphology0.80782040
71MP0000537_abnormal_urethra_morphology0.78682472
72MP0000858_altered_metastatic_potential0.78387411
73MP0005394_taste/olfaction_phenotype0.78059888
74MP0005499_abnormal_olfactory_system0.78059888
75MP0004858_abnormal_nervous_system0.74948423
76MP0003938_abnormal_ear_development0.73546811
77MP0000678_abnormal_parathyroid_gland0.72611930
78MP0005023_abnormal_wound_healing0.72232256
79MP0005076_abnormal_cell_differentiation0.71748896
80MP0000428_abnormal_craniofacial_morphol0.71292639
81MP0000613_abnormal_salivary_gland0.70952401
82MP0003045_fibrosis0.70391323
83MP0005390_skeleton_phenotype0.69828228
84MP0003638_abnormal_response/metabolism_0.69052144
85MP0000538_abnormal_urinary_bladder0.68528590
86MP0002108_abnormal_muscle_morphology0.65442346
87MP0002896_abnormal_bone_mineralization0.64163652
88MP0001348_abnormal_lacrimal_gland0.63805735
89MP0003315_abnormal_perineum_morphology0.62781968
90MP0001270_distended_abdomen0.61714367
91MP0005075_abnormal_melanosome_morpholog0.60056386
92MP0000163_abnormal_cartilage_morphology0.59038072
93MP0000432_abnormal_head_morphology0.58899017
94MP0002111_abnormal_tail_morphology0.58886715
95MP0004885_abnormal_endolymph0.58792327
96MP0000372_irregular_coat_pigmentation0.58180831
97MP0002877_abnormal_melanocyte_morpholog0.56926821
98MP0010352_gastrointestinal_tract_polyps0.56862621
99MP0002109_abnormal_limb_morphology0.56376498
100MP0005666_abnormal_adipose_tissue0.56055886
101MP0005083_abnormal_biliary_tract0.54909759
102MP0005670_abnormal_white_adipose0.54090009
103MP0003385_abnormal_body_wall0.54051304
104MP0001765_abnormal_ion_homeostasis0.53840609
105MP0003763_abnormal_thymus_physiology0.52378433
106MP0003698_abnormal_male_reproductive0.51554148
107MP0001784_abnormal_fluid_regulation0.51152608
108MP0003436_decreased_susceptibility_to0.50797520
109MP0003937_abnormal_limbs/digits/tail_de0.49558617
110MP0003935_abnormal_craniofacial_develop0.49492920
111MP0000003_abnormal_adipose_tissue0.47953133
112MP0003191_abnormal_cellular_cholesterol0.47594837
113MP0002115_abnormal_skeleton_extremities0.47354637
114MP0002166_altered_tumor_susceptibility0.47249711
115MP0001299_abnormal_eye_distance/0.45840804
116MP0001873_stomach_inflammation0.45454867
117MP0005248_abnormal_Harderian_gland0.44688851
118MP0000681_abnormal_thyroid_gland0.44570772
119MP0001958_emphysema0.43431859
120MP0002006_tumorigenesis0.43045430
121MP0002095_abnormal_skin_pigmentation0.42559062
122MP0009053_abnormal_anal_canal0.42361169
123MP0000685_abnormal_immune_system0.40846584
124MP0004782_abnormal_surfactant_physiolog0.40201106
125MP0000470_abnormal_stomach_morphology0.39728704
126MP0003942_abnormal_urinary_system0.39585559
127MP0002089_abnormal_postnatal_growth/wei0.39375663
128MP0005623_abnormal_meninges_morphology0.39113129
129MP0003828_pulmonary_edema0.38439439
130MP0005375_adipose_tissue_phenotype0.37237118
131MP0003950_abnormal_plasma_membrane0.33791119
132MP0003091_abnormal_cell_migration0.33325535
133MP0003448_altered_tumor_morphology0.32950563

Predicted human phenotypes

RankGene SetZ-score
1Fragile nails (HP:0001808)8.61840567
2Onycholysis (HP:0001806)6.22304757
3Plantar hyperkeratosis (HP:0007556)6.17891301
4Milia (HP:0001056)5.93440268
5Hypotrichosis (HP:0001006)5.87672480
6Abnormal hair laboratory examination (HP:0003328)5.21710684
7Abnormality of the salivary glands (HP:0010286)4.91614108
8Increased IgE level (HP:0003212)4.80044869
9Woolly hair (HP:0002224)4.66921334
10Concave nail (HP:0001598)4.38849645
11Atrophic scars (HP:0001075)4.37153398
12Right ventricular cardiomyopathy (HP:0011663)4.22856757
13Abnormality of cells of the erythroid lineage (HP:0012130)4.17784250
14Abnormal blistering of the skin (HP:0008066)4.10844387
15Down-sloping shoulders (HP:0200021)3.93592269
16Abnormality of the labia majora (HP:0012881)3.87007165
17Erythema (HP:0010783)3.81544920
18Absent eyelashes (HP:0000561)3.81540063
19Distal lower limb muscle weakness (HP:0009053)3.76845107
20Reticulocytopenia (HP:0001896)3.65315039
21Palmoplantar hyperkeratosis (HP:0000972)3.62590442
22Abnormal number of erythroid precursors (HP:0012131)3.52686284
23Parakeratosis (HP:0001036)3.44697737
24Abnormal hemoglobin (HP:0011902)3.37622816
25Palmar hyperkeratosis (HP:0010765)3.36707193
26Thick nail (HP:0001805)3.36329320
27Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.34373830
28Abnormality of secondary sexual hair (HP:0009888)3.32169738
29Abnormality of the axillary hair (HP:0100134)3.32169738
30Abnormality of the 2nd finger (HP:0004100)3.32146732
31Anhidrosis (HP:0000970)3.31223631
32Selective tooth agenesis (HP:0001592)3.30680616
33Nail dystrophy (HP:0008404)3.27908412
34Amyloidosis (HP:0011034)3.24641599
35Blepharitis (HP:0000498)3.11935406
36Ridged nail (HP:0001807)3.11000556
37Hypodontia (HP:0000668)3.09672740
38Sex reversal (HP:0012245)3.08957839
39Abnormal sex determination (HP:0012244)3.08957839
40Aplasia involving bones of the upper limbs (HP:0009823)3.03569361
41Aplasia of the phalanges of the hand (HP:0009802)3.03569361
42Aplasia involving bones of the extremities (HP:0009825)3.03569361
43Acanthosis nigricans (HP:0000956)3.01855085
44Congenital ichthyosiform erythroderma (HP:0007431)2.99980916
45Lip pit (HP:0100267)2.99948549
46Sparse scalp hair (HP:0002209)2.91252948
47Erythroderma (HP:0001019)2.83656579
48Oral leukoplakia (HP:0002745)2.83522271
49Aplasia cutis congenita (HP:0001057)2.82200509
50Duplicated collecting system (HP:0000081)2.79724531
51Bronchomalacia (HP:0002780)2.77028441
52Hyporeflexia of lower limbs (HP:0002600)2.71048267
53Sparse eyelashes (HP:0000653)2.70140561
54Absent eyebrow (HP:0002223)2.68798300
55Abnormality of hair growth rate (HP:0011363)2.68735401
56Slow-growing hair (HP:0002217)2.68735401
57Hypoparathyroidism (HP:0000829)2.68648035
58Macrocytic anemia (HP:0001972)2.66899208
59Pili torti (HP:0003777)2.64916489
60Hypoplasia of dental enamel (HP:0006297)2.64195831
61Palmoplantar keratoderma (HP:0000982)2.62017363
62Septate vagina (HP:0001153)2.61831392
63Malnutrition (HP:0004395)2.60958831
64Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.59689133
65Natal tooth (HP:0000695)2.59544149
66Conical tooth (HP:0000698)2.56532983
67Advanced eruption of teeth (HP:0006288)2.54805933
68Abnormality of permanent molar morphology (HP:0011071)2.51815364
69Abnormality of the dental root (HP:0006486)2.51815364
70Taurodontia (HP:0000679)2.51815364
71Depressed nasal tip (HP:0000437)2.51354978
72Split foot (HP:0001839)2.46168535
73Breast hypoplasia (HP:0003187)2.46116673
74Hypochromic anemia (HP:0001931)2.45787981
75Labial hypoplasia (HP:0000066)2.45575853
76Ankyloglossia (HP:0010296)2.41807298
77Abnormality of the renal collecting system (HP:0004742)2.39844638
78Pallor (HP:0000980)2.38994184
79Oligodontia (HP:0000677)2.38883669
80Abnormality of molar morphology (HP:0011070)2.38572860
81Abnormality of molar (HP:0011077)2.38572860
82Nasal polyposis (HP:0100582)2.37908408
83Alopecia of scalp (HP:0002293)2.37875822
84Absent hair (HP:0002298)2.31990973
85Humeroradial synostosis (HP:0003041)2.29307116
86Synostosis involving the elbow (HP:0003938)2.29307116
87Fragile skin (HP:0001030)2.28788762
88Pterygium (HP:0001059)2.27790201
89Obstructive sleep apnea (HP:0002870)2.27785445
90Hypoplastic female external genitalia (HP:0012815)2.26830696
91Severe Myopia (HP:0011003)2.26251697
92Corneal erosion (HP:0200020)2.24846687
93Abnormality of the dental pulp (HP:0006479)2.22819859
94Anonychia (HP:0001798)2.22702967
95Abnormality of nail color (HP:0100643)2.19830944
96Hyperkalemia (HP:0002153)2.17426464
97Popliteal pterygium (HP:0009756)2.16804536
98Premature loss of primary teeth (HP:0006323)2.14676594
99Chronic bronchitis (HP:0004469)2.13774047
100Ectropion (HP:0000656)2.12654344
101Neonatal short-limb short stature (HP:0008921)2.09140517
102Premature skin wrinkling (HP:0100678)2.07898972
103Abnormality of the lacrimal duct (HP:0011481)2.07602696
104Fatigable weakness (HP:0003473)2.07257062
105Abnormality of the neuromuscular junction (HP:0003398)2.07257062
106Abnormality of the middle phalanges of the toes (HP:0010183)2.01334563
107Increased connective tissue (HP:0009025)2.00412788
108Hypohidrosis (HP:0000966)2.00019040
109Sparse lateral eyebrow (HP:0005338)1.99876495
110Abnormality of the nasolacrimal system (HP:0000614)1.98785677
111Nasolacrimal duct obstruction (HP:0000579)1.96837177
112Ventricular tachycardia (HP:0004756)1.95745259
113Hypoplasia of the iris (HP:0007676)1.94264157
114Mixed hearing impairment (HP:0000410)1.94188431
115Abnormality of the nasal mucosa (HP:0000433)1.93174894
116Esophageal atresia (HP:0002032)1.93159170
117Hyperactive renin-angiotensin system (HP:0000841)1.92821244
118Absent hand (HP:0004050)1.90793434
119Hypoplastic labia majora (HP:0000059)1.89645561
12011 pairs of ribs (HP:0000878)1.89474312
121Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.87299385
122Pruritus (HP:0000989)1.86741833
123Morphological abnormality of the middle ear (HP:0008609)1.85696814
124Partial duplication of thumb phalanx (HP:0009944)1.85418175
125Ureteral duplication (HP:0000073)1.82157533
126Xerostomia (HP:0000217)1.80988160
127Abnormality of the nasal septum (HP:0000419)1.80069479
128Bifid scrotum (HP:0000048)1.79873571
129Amelogenesis imperfecta (HP:0000705)1.79265593
130Curly hair (HP:0002212)1.77132384
131Hydroureter (HP:0000072)1.76767754
132Vascular calcification (HP:0004934)1.76753153
133Dry hair (HP:0011359)1.76437609
134Congenital, generalized hypertrichosis (HP:0004540)1.76138341
135Skin pits (HP:0100276)1.75696286
136Renal dysplasia (HP:0000110)1.71703963
137Abnormality of oral frenula (HP:0000190)1.71610241
138Conjunctival hamartoma (HP:0100780)1.70807348
139Abnormality of the distal phalanges of the toes (HP:0010182)1.70139425
140Abnormality of the labia (HP:0000058)1.69947472
141Neonatal death (HP:0003811)1.69413931

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R5.80568280
2MAPKAPK35.22091459
3EPHB23.84251518
4TGFBR13.78148401
5RIPK13.31007983
6ERN13.17389724
7FER2.89374394
8MAP3K62.88261284
9RPS6KB22.87673886
10MAP3K32.85696661
11MST42.73411101
12SIK12.49815891
13TESK12.40177204
14LRRK22.17651318
15FGFR22.15046739
16TRPM72.05115190
17MAP3K22.03421815
18STK241.96628952
19MET1.83540501
20LATS11.82613852
21EEF2K1.82201964
22BCR1.81092856
23MAPKAPK51.78112041
24SMG11.72698804
25MAP3K11.72177587
26PBK1.69121455
27EPHA31.60103614
28PTK21.59750455
29TRIB31.50146931
30STK381.42578563
31NME11.41062638
32DDR21.37479345
33HIPK21.19768190
34ERBB31.16742710
35PRKD11.15552242
36EPHA41.14976001
37CDK121.14858295
38MAP2K21.14449133
39PTK61.10794875
40EPHA21.10443797
41FGFR31.08473378
42SIK31.06932208
43MATK1.05046895
44PIM21.04083075
45CDK61.03068963
46CSNK1G21.02802885
47MAPK150.99624782
48MAP3K90.97188862
49EPHB10.96522117
50GRK10.95670537
51PLK40.95455384
52DYRK1B0.95370911
53STK100.95342737
54FGFR40.94450890
55MAP3K70.89931478
56DAPK20.87808743
57ACVR1B0.87174968
58PIK3CG0.87033054
59MAP2K10.85894727
60BMPR20.84808475
61GRK60.78144885
62FGFR10.76316574
63MAPKAPK20.75480357
64PRKD30.72034089
65MTOR0.71047313
66PRKCI0.69534314
67TAOK10.68094125
68NTRK20.68063714
69IRAK10.67942498
70MAPK110.67412411
71PIK3CA0.66279029
72MAP2K60.64985209
73MARK20.63346304
74PRKD20.63019700
75NLK0.62763075
76LATS20.62532263
77CASK0.62079220
78GRK70.61880834
79CDC42BPA0.61181424
80CHUK0.58877391
81ROCK10.58785324
82CDK70.57800700
83STK38L0.56467500
84MAP3K140.56187231
85TYK20.55050992
86LMTK20.53225989
87TTN0.52382625
88CDK30.52106837
89TGFBR20.51848681
90MOS0.51572106
91NME20.51504171
92IRAK20.50935725
93STK110.48705279
94PDGFRA0.48542411
95ICK0.46881534
96IKBKB0.46268987
97PRKCE0.46225533
98MAPK70.46105853
99TLK10.45127333
100RPS6KA10.45113239
101BRD40.43831252
102IGF1R0.41391731
103MAPK120.41326999
104ITK0.39697633
105BTK0.39615533
106ADRBK10.39509287
107INSRR0.38901443
108PDPK10.38719027
109OBSCN0.38196527
110NTRK10.38106925
111RPS6KA20.38059982
112MAPK40.37736291
113PAK30.36774648
114CSNK1D0.35428351
115PAK40.35082096
116ARAF0.35019139
117STK30.34757501
118PASK0.34410018
119PRKAA20.33970012
120CDK190.33690801
121RPS6KL10.33618356
122RPS6KC10.33618356
123RPS6KB10.33525137
124JAK10.33372027
125BLK0.33027874
126MAPK30.32843073
127ERBB20.31247387
128DMPK0.30776129
129NEK60.30317024
130PRKACA0.28442176
131JAK30.28255317
132MAPK90.27890478
133BMX0.27818659
134HCK0.27644794
135PDGFRB0.26807482
136RIPK40.26732429
137MAP3K130.25532568
138ABL10.24322076
139ROCK20.22310948
140WNK10.20586192
141MAPK80.19689656
142CDK90.19390311
143KSR20.17026173
144TBK10.16844843
145SGK4940.13253769
146SGK2230.13253769
147IKBKE0.12662861
148SGK10.11718556

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.58323236
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.78685618
3Basal cell carcinoma_Homo sapiens_hsa052173.30015191
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.47675800
5Fatty acid biosynthesis_Homo sapiens_hsa000612.46436471
6Phototransduction_Homo sapiens_hsa047442.14875776
7ECM-receptor interaction_Homo sapiens_hsa045122.13915097
8Retinol metabolism_Homo sapiens_hsa008302.06242799
9Hedgehog signaling pathway_Homo sapiens_hsa043402.05877173
10Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.97687848
11Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.95814286
12Melanogenesis_Homo sapiens_hsa049161.88866444
13Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.70268277
14Hippo signaling pathway_Homo sapiens_hsa043901.65465664
15Protein digestion and absorption_Homo sapiens_hsa049741.62726141
16Axon guidance_Homo sapiens_hsa043601.60289564
17Acute myeloid leukemia_Homo sapiens_hsa052211.60016896
18Chemical carcinogenesis_Homo sapiens_hsa052041.59614332
19Sphingolipid metabolism_Homo sapiens_hsa006001.52004160
20Dorso-ventral axis formation_Homo sapiens_hsa043201.51982628
21Phenylalanine metabolism_Homo sapiens_hsa003601.51656833
22Amoebiasis_Homo sapiens_hsa051461.51621782
23Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.49261165
24Proteoglycans in cancer_Homo sapiens_hsa052051.47210670
25Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.41569144
26Glycerophospholipid metabolism_Homo sapiens_hsa005641.41083693
27Thyroid cancer_Homo sapiens_hsa052161.38401558
28Bladder cancer_Homo sapiens_hsa052191.30287442
29Wnt signaling pathway_Homo sapiens_hsa043101.27012224
30TGF-beta signaling pathway_Homo sapiens_hsa043501.25200551
31Circadian rhythm_Homo sapiens_hsa047101.25075530
32Linoleic acid metabolism_Homo sapiens_hsa005911.25067665
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.24785320
34Renin secretion_Homo sapiens_hsa049241.22728708
35Tyrosine metabolism_Homo sapiens_hsa003501.22065143
36Pancreatic cancer_Homo sapiens_hsa052121.20616363
37Endocytosis_Homo sapiens_hsa041441.17347895
38Histidine metabolism_Homo sapiens_hsa003401.16141957
39Tight junction_Homo sapiens_hsa045301.15762123
40Influenza A_Homo sapiens_hsa051641.15672436
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.08849587
42Adherens junction_Homo sapiens_hsa045201.06018191
43Autoimmune thyroid disease_Homo sapiens_hsa053201.05113602
44Salivary secretion_Homo sapiens_hsa049701.04184757
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04150433
46Gastric acid secretion_Homo sapiens_hsa049711.03046079
47Central carbon metabolism in cancer_Homo sapiens_hsa052300.99296290
48GnRH signaling pathway_Homo sapiens_hsa049120.98203104
49Rap1 signaling pathway_Homo sapiens_hsa040150.91925376
50Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89976919
51Melanoma_Homo sapiens_hsa052180.88999566
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88660606
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88023449
54TNF signaling pathway_Homo sapiens_hsa046680.87727777
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85922252
56Choline metabolism in cancer_Homo sapiens_hsa052310.85887536
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.85363078
58Mineral absorption_Homo sapiens_hsa049780.84792368
59Arachidonic acid metabolism_Homo sapiens_hsa005900.80454584
60VEGF signaling pathway_Homo sapiens_hsa043700.79537487
61Ras signaling pathway_Homo sapiens_hsa040140.79365310
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.79271639
63Chronic myeloid leukemia_Homo sapiens_hsa052200.79049797
64Hepatitis C_Homo sapiens_hsa051600.76310797
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.75168980
66Fatty acid degradation_Homo sapiens_hsa000710.75010927
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74511968
68Pathways in cancer_Homo sapiens_hsa052000.73331627
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72390806
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.71027607
71Calcium signaling pathway_Homo sapiens_hsa040200.70934618
72Insulin signaling pathway_Homo sapiens_hsa049100.69805915
73Focal adhesion_Homo sapiens_hsa045100.69797264
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69690569
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67577334
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67561811
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.67041136
78Endometrial cancer_Homo sapiens_hsa052130.66945388
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.66603606
80Small cell lung cancer_Homo sapiens_hsa052220.65012016
81Ether lipid metabolism_Homo sapiens_hsa005650.64916442
82beta-Alanine metabolism_Homo sapiens_hsa004100.64876735
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.64221068
84Prolactin signaling pathway_Homo sapiens_hsa049170.63731615
85Non-small cell lung cancer_Homo sapiens_hsa052230.63045882
86Staphylococcus aureus infection_Homo sapiens_hsa051500.62525673
87Platelet activation_Homo sapiens_hsa046110.62354922
88Glutathione metabolism_Homo sapiens_hsa004800.62099927
89Arginine biosynthesis_Homo sapiens_hsa002200.61743082
90Glycerolipid metabolism_Homo sapiens_hsa005610.61291960
91Fatty acid elongation_Homo sapiens_hsa000620.60909759
92Long-term depression_Homo sapiens_hsa047300.59967605
93Pancreatic secretion_Homo sapiens_hsa049720.59510687
94MicroRNAs in cancer_Homo sapiens_hsa052060.58302118
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58044260
96Complement and coagulation cascades_Homo sapiens_hsa046100.57658403
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56186381
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53768137
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53693222
100Toxoplasmosis_Homo sapiens_hsa051450.53210480
101ABC transporters_Homo sapiens_hsa020100.53108131
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52756454
103Jak-STAT signaling pathway_Homo sapiens_hsa046300.52104998
104PPAR signaling pathway_Homo sapiens_hsa033200.51080735
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50974427
106ErbB signaling pathway_Homo sapiens_hsa040120.50763658
107Oxytocin signaling pathway_Homo sapiens_hsa049210.50312401
108Primary bile acid biosynthesis_Homo sapiens_hsa001200.49505637
109Pertussis_Homo sapiens_hsa051330.48833126
110Prostate cancer_Homo sapiens_hsa052150.48655342
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.47813396
112Notch signaling pathway_Homo sapiens_hsa043300.47402952
113Hematopoietic cell lineage_Homo sapiens_hsa046400.47209820
114Dilated cardiomyopathy_Homo sapiens_hsa054140.47158939
115Antigen processing and presentation_Homo sapiens_hsa046120.46960522
116Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45852236
117Estrogen signaling pathway_Homo sapiens_hsa049150.45431143
118Steroid hormone biosynthesis_Homo sapiens_hsa001400.45364339
119HTLV-I infection_Homo sapiens_hsa051660.44414396
120cAMP signaling pathway_Homo sapiens_hsa040240.44396094
121Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44226410
122Insulin resistance_Homo sapiens_hsa049310.43573985
123RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43331656
124Inositol phosphate metabolism_Homo sapiens_hsa005620.42442496
125Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42313746
126Renal cell carcinoma_Homo sapiens_hsa052110.41061555
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40884890
128Serotonergic synapse_Homo sapiens_hsa047260.40864774
129Glioma_Homo sapiens_hsa052140.40633347
130Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40543689
131Olfactory transduction_Homo sapiens_hsa047400.40176150
132Malaria_Homo sapiens_hsa051440.38227300
133Tuberculosis_Homo sapiens_hsa051520.37605712
134Long-term potentiation_Homo sapiens_hsa047200.37478291
135MAPK signaling pathway_Homo sapiens_hsa040100.36629079
136p53 signaling pathway_Homo sapiens_hsa041150.36227918
137SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34288320
138Amphetamine addiction_Homo sapiens_hsa050310.33432472
139Osteoclast differentiation_Homo sapiens_hsa043800.32940205
140Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.32874526

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