KRT14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. At least one pseudogene has been identified at 17p12-p11. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of water loss via skin (GO:0033561)9.65130891
2peptide cross-linking (GO:0018149)7.44078556
3keratinocyte differentiation (GO:0030216)7.13752029
4* intermediate filament organization (GO:0045109)7.02628131
5* epidermis development (GO:0008544)6.90440456
6ectoderm development (GO:0007398)6.69766684
7bundle of His cell to Purkinje myocyte communication (GO:0086069)6.67311406
8multicellular organismal water homeostasis (GO:0050891)6.43582999
9keratinocyte development (GO:0003334)6.31354946
10skin morphogenesis (GO:0043589)5.79887776
11epidermal cell differentiation (GO:0009913)5.59479096
12keratinocyte proliferation (GO:0043616)5.53034583
13water homeostasis (GO:0030104)5.34395701
14surfactant homeostasis (GO:0043129)5.18410494
15gap junction assembly (GO:0016264)4.95937371
16* intermediate filament cytoskeleton organization (GO:0045104)4.83625707
17* cell-substrate junction assembly (GO:0007044)4.80182236
18negative regulation of keratinocyte proliferation (GO:0010839)4.79959654
19* intermediate filament-based process (GO:0045103)4.68748823
20epithelial cell differentiation involved in prostate gland development (GO:0060742)4.46309478
21atrioventricular valve morphogenesis (GO:0003181)4.34234610
22polarized epithelial cell differentiation (GO:0030859)4.31471622
23chemical homeostasis within a tissue (GO:0048875)4.30266057
24adhesion of symbiont to host cell (GO:0044650)4.23772258
25virion attachment to host cell (GO:0019062)4.23772258
26linoleic acid metabolic process (GO:0043651)3.97732955
27skin development (GO:0043588)3.95287053
28fatty acid elongation (GO:0030497)3.92233788
29regulation of hair follicle development (GO:0051797)3.87718277
30viral transcription (GO:0019083)3.86838373
31positive regulation of epidermis development (GO:0045684)3.77006904
32positive regulation of hair follicle development (GO:0051798)3.74099503
33positive regulation of hair cycle (GO:0042635)3.74099503
34positive regulation of keratinocyte differentiation (GO:0045618)3.69741848
35hair follicle morphogenesis (GO:0031069)3.65499796
36translational termination (GO:0006415)3.61796429
37lipoxygenase pathway (GO:0019372)3.58583111
38negative regulation of cell fate specification (GO:0009996)3.51470468
39adhesion of symbiont to host (GO:0044406)3.45744983
40lateral sprouting from an epithelium (GO:0060601)3.45102372
41ribosomal small subunit biogenesis (GO:0042274)3.44867469
42positive regulation of epidermal cell differentiation (GO:0045606)3.41195930
43* epithelium development (GO:0060429)3.37951270
44planar cell polarity pathway involved in neural tube closure (GO:0090179)3.36969146
45negative regulation of epidermis development (GO:0045683)3.27852075
46regulation of hair cycle (GO:0042634)3.24688017
47cell adhesion mediated by integrin (GO:0033627)3.24531931
48interferon-gamma secretion (GO:0072643)3.22898906
49protein localization to endosome (GO:0036010)3.20415881
50regulation of ruffle assembly (GO:1900027)3.19912120
51negative regulation of interferon-gamma production (GO:0032689)3.19242714
52eyelid development in camera-type eye (GO:0061029)3.18101497
53cardiac right ventricle morphogenesis (GO:0003215)3.17135387
54regulation of epidermis development (GO:0045682)3.15355717
55hair cycle process (GO:0022405)3.14550158
56molting cycle process (GO:0022404)3.14550158
57negative regulation of chondrocyte differentiation (GO:0032331)3.11278879
58regulation of heart rate by cardiac conduction (GO:0086091)3.11134357
59regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.10728447
60cell communication involved in cardiac conduction (GO:0086065)3.10081424
61regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.06046618
62regulation of keratinocyte proliferation (GO:0010837)3.01121848
63endodermal cell differentiation (GO:0035987)2.98830009
64regulation of transforming growth factor beta2 production (GO:0032909)2.96954719
65regulation of cardioblast differentiation (GO:0051890)2.95756070
66hypotonic response (GO:0006971)2.94745523
67establishment of planar polarity (GO:0001736)2.93336967
68establishment of tissue polarity (GO:0007164)2.93336967
69negative regulation of cell fate commitment (GO:0010454)2.93265158
70positive regulation of vesicle fusion (GO:0031340)2.92890138
71regulation of chemokine secretion (GO:0090196)2.91378455
72cytoskeletal anchoring at plasma membrane (GO:0007016)2.87871509
73positive regulation of protein export from nucleus (GO:0046827)2.87270545
74translational elongation (GO:0006414)2.86919200
75detection of bacterium (GO:0016045)2.85882704
76regulation of phospholipase A2 activity (GO:0032429)2.83380234
77* cell junction assembly (GO:0034329)2.83049245
78* cell junction organization (GO:0034330)2.82728988
79long-chain fatty acid biosynthetic process (GO:0042759)2.82466517
80fibrinolysis (GO:0042730)2.80272483
81odontogenesis of dentin-containing tooth (GO:0042475)2.79045798
82SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.78588805
83viral life cycle (GO:0019058)2.78119956
84odontogenesis (GO:0042476)2.77791589
85regulation of cell proliferation involved in kidney development (GO:1901722)2.77707060
86gland morphogenesis (GO:0022612)2.76079941
87regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.75427054
88protein targeting to ER (GO:0045047)2.75324645
89hair follicle development (GO:0001942)2.74797343
90wound healing, spreading of epidermal cells (GO:0035313)2.74164319
91positive regulation of monocyte chemotaxis (GO:0090026)2.73275983
92phosphatidylserine metabolic process (GO:0006658)2.71999505
93cotranslational protein targeting to membrane (GO:0006613)2.71470897
94cellular protein complex disassembly (GO:0043624)2.71086716
95epithelial cell-cell adhesion (GO:0090136)2.68027429
96establishment of protein localization to endoplasmic reticulum (GO:0072599)2.66544110
97epithelial cell proliferation (GO:0050673)2.66007530
98phosphatidylinositol acyl-chain remodeling (GO:0036149)2.65429222
99wound healing (GO:0042060)2.64584835
100phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.62437699
101phosphatidylcholine acyl-chain remodeling (GO:0036151)2.61621765
102regulation of epidermal cell differentiation (GO:0045604)2.58516303
103maturation of SSU-rRNA (GO:0030490)2.57519864
104regulation of keratinocyte differentiation (GO:0045616)2.57147752
105nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.56969127
106renal system development (GO:0072001)2.56766228
107ventricular cardiac muscle cell action potential (GO:0086005)2.56199115
108heart valve morphogenesis (GO:0003179)2.54718193
109mesodermal cell differentiation (GO:0048333)2.54092463
110ribosomal small subunit assembly (GO:0000028)2.53595495
111phosphatidylserine acyl-chain remodeling (GO:0036150)2.52710358
112protein localization to endoplasmic reticulum (GO:0070972)2.51422427
113renal filtration (GO:0097205)2.50392941
114regulation of natural killer cell differentiation (GO:0032823)2.49981480
115intestinal epithelial cell development (GO:0060576)2.46612744
116cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.46458325
117morphogenesis of embryonic epithelium (GO:0016331)2.44974390
118dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.44887202
119negative regulation of axon extension involved in axon guidance (GO:0048843)2.43516637
120cardiac conduction (GO:0061337)2.43275182
121regulation of transforming growth factor beta1 production (GO:0032908)2.42775526
122membrane budding (GO:0006900)2.41396946
123detection of other organism (GO:0098543)2.41105774
124non-canonical Wnt signaling pathway (GO:0035567)2.39222647
125wound healing, spreading of cells (GO:0044319)2.38479063
126positive regulation of chemokine secretion (GO:0090197)2.37154562
127phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.36167357
128extracellular matrix disassembly (GO:0022617)2.36033222
129lung lobe morphogenesis (GO:0060463)2.34709523
130membrane tubulation (GO:0097320)2.34083060
131regulation of protein localization to cell surface (GO:2000008)2.33638154
132* hair cycle (GO:0042633)14.9937955
133* molting cycle (GO:0042303)14.9937955
134* hemidesmosome assembly (GO:0031581)14.7480593
135keratinization (GO:0031424)14.6091581
136desmosome organization (GO:0002934)13.8434077
137establishment of skin barrier (GO:0061436)10.4827162

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.87606047
2* P63_26484246_Chip-Seq_KERATINOCYTES_Human3.00581023
3STAT6_21828071_ChIP-Seq_BEAS2B_Human2.87393381
4* SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.78241840
5SOX9_24532713_ChIP-Seq_HFSC_Mouse2.69946281
6ESR1_21235772_ChIP-Seq_MCF-7_Human2.32806932
7* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.18403470
8* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.18403470
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.14451894
10ZNF263_19887448_ChIP-Seq_K562_Human2.14422226
11CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.01524656
12* TP63_17297297_ChIP-ChIP_HaCaT_Human16.1194685
13ESR2_21235772_ChIP-Seq_MCF-7_Human1.85593721
14FOXO3_23340844_ChIP-Seq_DLD1_Human1.74537289
15RARG_19884340_ChIP-ChIP_MEFs_Mouse1.46353723
16RACK7_27058665_Chip-Seq_MCF-7_Human1.45341248
17ATF3_27146783_Chip-Seq_COLON_Human1.39708048
18HIF1A_21447827_ChIP-Seq_MCF-7_Human1.37101532
19KLF5_25053715_ChIP-Seq_YYC3_Human1.31981513
20* TP63_22573176_ChIP-Seq_HFKS_Human1.31712994
21TP53_20018659_ChIP-ChIP_R1E_Mouse1.31705608
22* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30665695
23TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30373977
24ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.28832048
25PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.28671909
26CJUN_26792858_Chip-Seq_BT549_Human1.28635900
27PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.28593337
28KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25303105
29TP63_23658742_ChIP-Seq_EP156T_Human1.24865528
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.23980071
31SOX2_20726797_ChIP-Seq_SW620_Human1.23647601
32KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22527298
33AR_21572438_ChIP-Seq_LNCaP_Human1.21814661
34* EGR1_19032775_ChIP-ChIP_M12_Human1.19401511
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15644873
36* UBF1/2_26484160_Chip-Seq_HMECs_Human1.15641873
37RUNX1_27514584_Chip-Seq_MCF-7_Human1.13326449
38ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.12985854
39LXR_22292898_ChIP-Seq_THP-1_Human1.12087724
40CTCF_27219007_Chip-Seq_Bcells_Human1.10463867
41BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.07576889
42DNAJC2_21179169_ChIP-ChIP_NT2_Human1.06607140
43RXR_22108803_ChIP-Seq_LS180_Human1.06414667
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.06123019
45TCF4_18268006_ChIP-ChIP_LS174T_Human1.05720303
46TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03860531
47CLOCK_20551151_ChIP-Seq_293T_Human1.01587484
48TP53_18474530_ChIP-ChIP_U2OS_Human1.01580259
49SA1_27219007_Chip-Seq_ERYTHROID_Human1.01211610
50TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00378965
51AHR_22903824_ChIP-Seq_MCF-7_Human0.99706783
52JARID2_20075857_ChIP-Seq_MESCs_Mouse0.95141003
53GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.94954015
54JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93963835
55GATA3_24758297_ChIP-Seq_MCF-7_Human0.93251683
56ELK3_25401928_ChIP-Seq_HUVEC_Human0.93051541
57SOX2_27498859_Chip-Seq_STOMACH_Mouse0.92558866
58CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.92516532
59JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91371774
60* P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.91363266
61ERG_21242973_ChIP-ChIP_JURKAT_Human0.91016601
62RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.89349562
63FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.88457731
64* CTCF_20526341_ChIP-Seq_ESCs_Human0.87695591
65GATA2_21666600_ChIP-Seq_HMVEC_Human0.87656965
66SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.86889608
67STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.84876468
68RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.84276051
69RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83240874
70P300_27058665_Chip-Seq_ZR-75-30cells_Human0.82872032
71KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.82349677
72EZH2_27304074_Chip-Seq_ESCs_Mouse0.81962102
73SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.81078055
74GATA6_25053715_ChIP-Seq_YYC3_Human0.80779077
75TBX20_22328084_ChIP-Seq_HEART_Mouse0.80231075
76TBX20_22080862_ChIP-Seq_HEART_Mouse0.80231075
77GATA6_21074721_ChIP-Seq_CACO-2_Human0.79955719
78KDM2B_26808549_Chip-Seq_K562_Human0.79395459
79EZH2_18974828_ChIP-Seq_MESCs_Mouse0.78740036
80RNF2_18974828_ChIP-Seq_MESCs_Mouse0.78740036
81CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.78536764
82CDX2_20551321_ChIP-Seq_CACO-2_Human0.78437486
83TP53_16413492_ChIP-PET_HCT116_Human0.77413352
84BCOR_27268052_Chip-Seq_Bcells_Human0.77252085
85RNF2_27304074_Chip-Seq_ESCs_Mouse0.77180595
86EZH2_27294783_Chip-Seq_ESCs_Mouse0.76745594
87SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.75790974
88ARNT_22903824_ChIP-Seq_MCF-7_Human0.75518097
89* E2F1_20622854_ChIP-Seq_HELA_Human0.75179398
90SMC4_20622854_ChIP-Seq_HELA_Human0.74901621
91SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.74715131
92NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.74520777
93ERG_20517297_ChIP-Seq_VCAP_Human0.74520245
94EED_16625203_ChIP-ChIP_MESCs_Mouse0.73532279
95TET1_21490601_ChIP-Seq_MESCs_Mouse0.73351353
96ESR1_20079471_ChIP-ChIP_T-47D_Human0.72873737
97PPAR_26484153_Chip-Seq_NCI-H1993_Human0.71749447
98HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.71697953
99KDM2B_26808549_Chip-Seq_SUP-B15_Human0.71372378
100ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.71207164
101SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.70059468
102NANOG_20526341_ChIP-Seq_ESCs_Human0.70000844
103WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.69911162
104KDM2B_26808549_Chip-Seq_JURKAT_Human0.68665341
105BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.68385960
106SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.67779066
107GATA4_25053715_ChIP-Seq_YYC3_Human0.67531342
108CEBPB_22108803_ChIP-Seq_LS180_Human0.67246445
109ZFP281_18757296_ChIP-ChIP_E14_Mouse0.67242566
110CSB_26484114_Chip-Seq_FIBROBLAST_Human0.65812894
111ELK4_26923725_Chip-Seq_MESODERM_Mouse0.65237183
112YY1_22570637_ChIP-Seq_MALME-3M_Human0.64768773
113SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.64721204
114EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.63861668
115GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.62813268
116SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.60879936
117TP53_22127205_ChIP-Seq_IMR90_Human0.60727656
118KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.59540443
119TP53_23651856_ChIP-Seq_MEFs_Mouse0.57966516
120NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.57801488
121ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.57263008
122TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.53896196
123PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.53501474
124THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.51228949
125FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.49269690

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology7.67410133
2MP0002796_impaired_skin_barrier6.85995639
3MP0005275_abnormal_skin_tensile5.19529538
4MP0005501_abnormal_skin_physiology4.27636037
5MP0010234_abnormal_vibrissa_follicle3.99274805
6MP0002254_reproductive_system_inflammat3.63763265
7* MP0000467_abnormal_esophagus_morphology3.57421362
8MP0002060_abnormal_skin_morphology3.55624803
9* MP0001216_abnormal_epidermal_layer3.49469213
10MP0000647_abnormal_sebaceous_gland3.38229790
11MP0002098_abnormal_vibrissa_morphology3.26385534
12* MP0000383_abnormal_hair_follicle3.24801802
13MP0000762_abnormal_tongue_morphology3.23036288
14MP0003705_abnormal_hypodermis_morpholog3.02518886
15* MP0004381_abnormal_hair_follicle2.87458600
16* MP0010771_integument_phenotype2.83516230
17* MP0010678_abnormal_skin_adnexa2.75816006
18MP0000427_abnormal_hair_cycle2.70093103
19MP0003941_abnormal_skin_development2.67863664
20* MP0003453_abnormal_keratinocyte_physiol2.64154281
21* MP0000377_abnormal_hair_follicle2.56360957
22MP0002234_abnormal_pharynx_morphology2.36578770
23MP0004947_skin_inflammation2.27675565
24MP0003566_abnormal_cell_adhesion2.22302287
25MP0009053_abnormal_anal_canal1.71836564
26MP0001849_ear_inflammation1.71096292
27MP0001243_abnormal_dermal_layer1.70633732
28* MP0009931_abnormal_skin_appearance1.66866583
29MP0001851_eye_inflammation1.64636087
30MP0000566_synostosis1.61062997
31MP0004885_abnormal_endolymph1.53192189
32* MP0000367_abnormal_coat/_hair1.48659169
33MP0001346_abnormal_lacrimal_gland1.45710308
34* MP0001191_abnormal_skin_condition1.40968637
35MP0005023_abnormal_wound_healing1.39459944
36MP0010030_abnormal_orbit_morphology1.37969313
37MP0008260_abnormal_autophagy1.18293220
38MP0003136_yellow_coat_color1.17939423
39MP0005451_abnormal_body_composition1.14827118
40MP0009379_abnormal_foot_pigmentation1.13213098
41MP0004185_abnormal_adipocyte_glucose1.13020055
42MP0003755_abnormal_palate_morphology1.04992332
43MP0004272_abnormal_basement_membrane1.01465336
44MP0001340_abnormal_eyelid_morphology0.99631002
45MP0008789_abnormal_olfactory_epithelium0.98570144
46MP0008438_abnormal_cutaneous_collagen0.97519684
47MP0003315_abnormal_perineum_morphology0.89282132
48MP0003878_abnormal_ear_physiology0.88804672
49MP0005377_hearing/vestibular/ear_phenot0.88804672
50MP0002877_abnormal_melanocyte_morpholog0.80981743
51MP0000627_abnormal_mammary_gland0.76564235
52MP0000465_gastrointestinal_hemorrhage0.76280821
53MP0005394_taste/olfaction_phenotype0.73137546
54MP0005499_abnormal_olfactory_system0.73137546
55MP0002233_abnormal_nose_morphology0.72137454
56MP0010352_gastrointestinal_tract_polyps0.71491138
57MP0000537_abnormal_urethra_morphology0.69619054
58MP0000015_abnormal_ear_pigmentation0.68694990
59MP0000538_abnormal_urinary_bladder0.67864393
60MP0003300_gastrointestinal_ulcer0.62329339
61MP0002111_abnormal_tail_morphology0.61022946
62MP0005076_abnormal_cell_differentiation0.57865174
63MP0002177_abnormal_outer_ear0.56931693
64MP0004264_abnormal_extraembryonic_tissu0.56099751
65MP0009780_abnormal_chondrocyte_physiolo0.56014987
66MP0003191_abnormal_cellular_cholesterol0.55510927
67MP0002249_abnormal_larynx_morphology0.54822545
68MP0003011_delayed_dark_adaptation0.51615690
69MP0001784_abnormal_fluid_regulation0.51490213
70MP0002095_abnormal_skin_pigmentation0.50692010
71MP0001299_abnormal_eye_distance/0.50652223
72MP0000858_altered_metastatic_potential0.50586217
73MP0003045_fibrosis0.49793446
74MP0005508_abnormal_skeleton_morphology0.49395868
75MP0004019_abnormal_vitamin_homeostasis0.46913193
76MP0000462_abnormal_digestive_system0.46734545
77MP0005174_abnormal_tail_pigmentation0.45594677
78MP0003385_abnormal_body_wall0.45110714
79MP0001958_emphysema0.40584820
80MP0000432_abnormal_head_morphology0.40087412
81MP0003950_abnormal_plasma_membrane0.39695020
82MP0001188_hyperpigmentation0.39580940
83MP0009384_cardiac_valve_regurgitation0.39418019
84MP0000569_abnormal_digit_pigmentation0.38785172
85MP0004782_abnormal_surfactant_physiolog0.37830571
86MP0005075_abnormal_melanosome_morpholog0.37592848
87MP0003091_abnormal_cell_migration0.36987659
88MP0000470_abnormal_stomach_morphology0.36898726
89* MP0005409_darkened_coat_color0.36656502
90MP0001542_abnormal_bone_strength0.36562682
91MP0003448_altered_tumor_morphology0.35943803
92MP0000750_abnormal_muscle_regeneration0.34163837
93MP0002009_preneoplasia0.34092065
94MP0000613_abnormal_salivary_gland0.32967259
95MP0002166_altered_tumor_susceptibility0.32515877
96MP0009250_abnormal_appendicular_skeleto0.32444001
97MP0006054_spinal_hemorrhage0.32036496
98MP0003436_decreased_susceptibility_to0.31585306
99MP0005360_urolithiasis0.31509675
100MP0002896_abnormal_bone_mineralization0.31317679
101MP0005197_abnormal_uvea_morphology0.30593395
102MP0002006_tumorigenesis0.30498051
103MP0003763_abnormal_thymus_physiology0.30382971
104MP0005248_abnormal_Harderian_gland0.29619862
105MP0003329_amyloid_beta_deposits0.29588943
106MP0002089_abnormal_postnatal_growth/wei0.28015849
107MP0004858_abnormal_nervous_system0.27695813
108MP0005666_abnormal_adipose_tissue0.27356293
109MP0006138_congestive_heart_failure0.27263843
110MP0005375_adipose_tissue_phenotype0.26980549
111MP0003638_abnormal_response/metabolism_0.26601748
112MP0005257_abnormal_intraocular_pressure0.26524268
113MP0002133_abnormal_respiratory_system0.26197720
114MP0005388_respiratory_system_phenotype0.26197720
115MP0005390_skeleton_phenotype0.25844538
116* MP0005193_abnormal_anterior_eye0.25444414
117MP0002109_abnormal_limb_morphology0.24907713
118MP0002697_abnormal_eye_size0.24871661
119MP0002090_abnormal_vision0.24611525
120MP0004197_abnormal_fetal_growth/weight/0.23493283
121* MP0002282_abnormal_trachea_morphology0.23242100
122MP0008569_lethality_at_weaning0.23195753
123MP0005187_abnormal_penis_morphology0.22484819
124MP0000678_abnormal_parathyroid_gland0.21337646
125MP0003937_abnormal_limbs/digits/tail_de0.20505712

Predicted human phenotypes

RankGene SetZ-score
1Onycholysis (HP:0001806)8.09083954
2* Plantar hyperkeratosis (HP:0007556)7.96294997
3* Milia (HP:0001056)7.83692427
4Hypotrichosis (HP:0001006)7.68685930
5* Thick nail (HP:0001805)7.49395569
6* Fragile nails (HP:0001808)6.75464544
7* Palmoplantar hyperkeratosis (HP:0000972)6.57970210
8Woolly hair (HP:0002224)6.31832496
9* Palmar hyperkeratosis (HP:0010765)6.17688706
10Atrophic scars (HP:0001075)5.84745874
11Oral leukoplakia (HP:0002745)5.53601183
12Follicular hyperkeratosis (HP:0007502)5.41987400
13Pili torti (HP:0003777)5.32627602
14* Nail dystrophy (HP:0008404)5.26216722
15* Abnormal blistering of the skin (HP:0008066)5.15702342
16Increased IgE level (HP:0003212)5.14585171
17Right ventricular cardiomyopathy (HP:0011663)4.72541377
18Erythema (HP:0010783)3.65965588
19Laryngomalacia (HP:0001601)3.49701067
20Aplasia cutis congenita (HP:0001057)3.36986787
21Erythroderma (HP:0001019)3.28719121
22Sparse eyelashes (HP:0000653)3.28683978
23Fragile skin (HP:0001030)3.26700937
24Abnormal hair laboratory examination (HP:0003328)3.24143409
25Parakeratosis (HP:0001036)3.20072259
26Anonychia (HP:0001798)3.18768155
27Natal tooth (HP:0000695)3.14483008
28Selective tooth agenesis (HP:0001592)3.06971649
29* Ridged nail (HP:0001807)3.06531954
30Lip pit (HP:0100267)3.03538431
31Congenital ichthyosiform erythroderma (HP:0007431)3.03456388
32* Palmoplantar keratoderma (HP:0000982)2.91836169
33Advanced eruption of teeth (HP:0006288)2.90811758
34Conjunctival hamartoma (HP:0100780)2.84968769
35Ectropion (HP:0000656)2.84526135
36Corneal dystrophy (HP:0001131)2.83150595
37* Alopecia of scalp (HP:0002293)2.77182207
38* Hyperhidrosis (HP:0000975)2.76923767
39Corneal erosion (HP:0200020)2.69030430
40Hypoplastic labia majora (HP:0000059)2.67549082
41Amelogenesis imperfecta (HP:0000705)2.43802098
42Hypoplasia of dental enamel (HP:0006297)2.43300693
43Abnormality of the labia majora (HP:0012881)2.42011226
44Blepharitis (HP:0000498)2.41965904
45Esophageal atresia (HP:0002032)2.39881979
46Ventricular tachycardia (HP:0004756)2.36251501
47Brittle hair (HP:0002299)2.35795127
48Acanthosis nigricans (HP:0000956)2.31179988
49Sparse scalp hair (HP:0002209)2.29723936
50Gangrene (HP:0100758)2.28826731
51Concave nail (HP:0001598)2.28706875
52Pterygium (HP:0001059)2.25230723
53Curly hair (HP:0002212)2.23598933
54* Abnormality of the fingernails (HP:0001231)2.22659374
55* Hypohidrosis (HP:0000966)2.22200978
56Increased connective tissue (HP:0009025)2.21541091
57* Carious teeth (HP:0000670)2.18927020
58Distal lower limb muscle weakness (HP:0009053)2.17026286
59Absent eyelashes (HP:0000561)2.04642497
60Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.04069815
61Pruritus (HP:0000989)2.03583496
62Slow-growing hair (HP:0002217)2.01074460
63Abnormality of hair growth rate (HP:0011363)2.01074460
64Abnormality of nail color (HP:0100643)11.5600738
65Xerostomia (HP:0000217)1.99316906
66Aplasia involving bones of the upper limbs (HP:0009823)1.98729895
67Aplasia of the phalanges of the hand (HP:0009802)1.98729895
68Aplasia involving bones of the extremities (HP:0009825)1.98729895
69Premature rupture of membranes (HP:0001788)1.97342910
70Dehydration (HP:0001944)1.91730408
71Multifactorial inheritance (HP:0001426)1.87441598
72* Skin ulcer (HP:0200042)1.84843658
73* Abnormality of the neuromuscular junction (HP:0003398)1.80961587
74* Fatigable weakness (HP:0003473)1.80961587
75Conical tooth (HP:0000698)1.80705920
76Ankyloglossia (HP:0010296)1.78353857
77Septate vagina (HP:0001153)1.77493288
78Pustule (HP:0200039)1.77324035
79Nasolacrimal duct obstruction (HP:0000579)1.76319762
80Congenital, generalized hypertrichosis (HP:0004540)1.75730089
81Hyporeflexia of lower limbs (HP:0002600)1.75663963
82Split foot (HP:0001839)1.75126856
83Down-sloping shoulders (HP:0200021)1.74608013
84Verrucae (HP:0200043)1.73990396
85Papilloma (HP:0012740)1.73990396
86Hypodontia (HP:0000668)1.73266948
87Dry hair (HP:0011359)1.72204196
88Autoamputation (HP:0001218)1.69614932
89Type 1 muscle fiber predominance (HP:0003803)1.69509036
90Recurrent corneal erosions (HP:0000495)1.69123055
91Abnormality of oral frenula (HP:0000190)1.64176718
92Absent hair (HP:0002298)1.62765777
93Breast hypoplasia (HP:0003187)1.62576391
94Abnormality of the gastric mucosa (HP:0004295)1.60785764
95Abnormality of permanent molar morphology (HP:0011071)1.59584265
96Abnormality of the dental root (HP:0006486)1.59584265
97Taurodontia (HP:0000679)1.59584265
98Melanocytic nevus (HP:0000995)1.59327148
99Labial hypoplasia (HP:0000066)1.59232514
100Epidermoid cyst (HP:0200040)1.58536791
101Fine hair (HP:0002213)1.58374109
102Hamartoma of the eye (HP:0010568)1.58090988
103Hypergammaglobulinemia (HP:0010702)1.57294935
104Furrowed tongue (HP:0000221)1.57088548
105Abnormal hemoglobin (HP:0011902)1.56959085
106Oligodontia (HP:0000677)1.54983173
107Abnormality of secondary sexual hair (HP:0009888)1.54415833
108Abnormality of the axillary hair (HP:0100134)1.54415833
109Absent eyebrow (HP:0002223)1.54404042
110Abnormality of the salivary glands (HP:0010286)1.54250197
111Abnormality of cells of the erythroid lineage (HP:0012130)1.53904424
112Distal lower limb amyotrophy (HP:0008944)1.51836961
113Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.51782438
114Abnormality of molar morphology (HP:0011070)1.49920316
115Abnormality of molar (HP:0011077)1.49920316
116Duplicated collecting system (HP:0000081)1.49189931
117Popliteal pterygium (HP:0009756)1.48852899
118Ureteral stenosis (HP:0000071)1.47603790
119Achilles tendon contracture (HP:0001771)1.46965664
120Abnormality of placental membranes (HP:0011409)1.46338200
121Amniotic constriction ring (HP:0009775)1.46338200
122Hypoplastic female external genitalia (HP:0012815)1.45740524
123Round ear (HP:0100830)1.45595212
124Neonatal death (HP:0003811)1.45211190
125Abnormality of the parietal bone (HP:0002696)1.44607613
126Axonal loss (HP:0003447)1.43014952
127Premature loss of primary teeth (HP:0006323)1.40884000
128Abnormality of the distal phalanges of the toes (HP:0010182)1.39543254

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R4.48132497
2MAP3K34.37523943
3FER3.85457467
4MAPKAPK33.58715266
5EPHA23.30494677
6ARAF3.07708763
7ERN12.95420565
8TRIB32.82452814
9MAP3K22.54594531
10EPHB22.54170877
11NTRK12.35691375
12FGFR22.03217130
13EPHA32.02295965
14NME11.99048017
15MET1.95448910
16EEF2K1.93997853
17RPS6KA41.89948194
18TYK21.87352377
19RPS6KB21.81693065
20EPHB11.72121584
21TAOK11.69155628
22MST41.67150545
23STK241.64761736
24TRPM71.62443299
25FGFR41.60867781
26LRRK21.59495843
27LATS11.56933811
28RIPK11.52377441
29MAPKAPK51.50763447
30TGFBR21.50104329
31PIK3CG1.45422823
32MAP3K111.41044288
33MAP3K11.40109619
34PAK41.31487072
35PIM21.30328682
36STK101.28942391
37KSR21.28556572
38FLT31.28063613
39PBK1.27894889
40PTK61.24756787
41SMG11.24564765
42TTN1.20440693
43MAP3K61.15259934
44CDK121.13297583
45MAPKAPK21.08183994
46MAP2K61.07882179
47FGFR11.07146972
48FGFR31.06099642
49PKN21.05987065
50TESK11.05542358
51ERBB31.04314321
52LMTK21.02154519
53BLK1.01266822
54DMPK0.97571564
55SIK10.95314216
56CDK60.93399524
57LATS20.91343351
58PRKD20.88551269
59PRPF4B0.88157265
60PTK20.86577907
61ILK0.86320199
62BMX0.83510315
63MAPK150.82910676
64MAP2K20.82155615
65BRAF0.80912999
66DYRK1B0.80471362
67SGK4940.78124553
68SGK2230.78124553
69RAF10.74490602
70STK380.73215508
71RPS6KA10.71953934
72MAP2K10.71176913
73PDGFRB0.66622280
74MAP3K120.65311301
75GRK60.64087073
76ROCK20.63243231
77CDC42BPA0.62409488
78STK38L0.59114987
79PRKD10.57906853
80GRK70.56792460
81ERBB20.54873436
82JAK10.54596254
83HIPK20.52587843
84MAP3K70.51031998
85PDGFRA0.50709311
86MAP2K30.50474680
87MTOR0.50372174
88BCR0.48779275
89DDR20.48484049
90NME20.48308359
91MAP3K90.48098353
92MAP3K130.47048251
93PAK20.45635723
94BMPR20.44674458
95NEK60.44335814
96RPS6KB10.44219736
97MOS0.42725909
98IKBKE0.40623852
99TBK10.40107674
100OBSCN0.37932962
101MAPK120.37692005
102MUSK0.37189879
103PRKCI0.37158947
104RET0.36189945
105GSK3A0.36181270
106NTRK20.35241840
107ADRBK10.35080811
108ICK0.34948771
109JAK20.34790080
110IRAK30.34413174
111MAPK70.34388317
112TGFBR10.33355682
113LIMK10.31547323
114FGR0.31204222
115WNK10.30613510
116MARK20.30346493
117RPS6KC10.29889161
118RPS6KL10.29889161
119MAP3K140.29786144
120ABL20.29536692
121RPS6KA20.28482422
122RPS6KA60.26865491
123MAP3K50.26760647
124MAP3K80.26225551
125ROCK10.26137071
126HCK0.25898787
127MAPK40.25166690
128MAP2K40.24464273
129CSF1R0.24192001
130IKBKB0.22815313
131SRC0.22489145
132IRAK10.22206505
133SGK30.22159931
134CHUK0.22133869
135NLK0.21758476
136JAK30.20493078
137PRKCE0.20382375
138STK30.19371451

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.21490138
2ECM-receptor interaction_Homo sapiens_hsa045123.12181928
3Basal cell carcinoma_Homo sapiens_hsa052173.07658156
4Ribosome_Homo sapiens_hsa030102.97237902
5Linoleic acid metabolism_Homo sapiens_hsa005912.46182451
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.41036701
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.37411812
8Hedgehog signaling pathway_Homo sapiens_hsa043402.37360928
9Fatty acid elongation_Homo sapiens_hsa000622.29312890
10Amoebiasis_Homo sapiens_hsa051462.22875146
11Phenylalanine metabolism_Homo sapiens_hsa003602.04899905
12Toxoplasmosis_Homo sapiens_hsa051451.76315032
13Proteoglycans in cancer_Homo sapiens_hsa052051.71334482
14Arachidonic acid metabolism_Homo sapiens_hsa005901.69294927
15Small cell lung cancer_Homo sapiens_hsa052221.68761951
16Hippo signaling pathway_Homo sapiens_hsa043901.65498846
17Steroid biosynthesis_Homo sapiens_hsa001001.62770023
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.58398432
19Bladder cancer_Homo sapiens_hsa052191.54710038
20Histidine metabolism_Homo sapiens_hsa003401.46642264
21Ether lipid metabolism_Homo sapiens_hsa005651.45561570
22Focal adhesion_Homo sapiens_hsa045101.41677145
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.39547938
24Melanogenesis_Homo sapiens_hsa049161.37433069
25Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.37154342
26Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.34896447
27Axon guidance_Homo sapiens_hsa043601.28272589
28VEGF signaling pathway_Homo sapiens_hsa043701.26985402
29Adherens junction_Homo sapiens_hsa045201.24990828
30Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.24757565
31Protein digestion and absorption_Homo sapiens_hsa049741.22063134
32Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.18834302
33Notch signaling pathway_Homo sapiens_hsa043301.18043952
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.17371496
35Ovarian steroidogenesis_Homo sapiens_hsa049131.15152147
36Caffeine metabolism_Homo sapiens_hsa002321.13112125
37GnRH signaling pathway_Homo sapiens_hsa049121.12304363
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.07532470
39Acute myeloid leukemia_Homo sapiens_hsa052211.06118547
40Fat digestion and absorption_Homo sapiens_hsa049751.04938816
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.03195288
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02653659
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.01182487
44Tight junction_Homo sapiens_hsa045301.01026512
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.00465416
46Glycerophospholipid metabolism_Homo sapiens_hsa005641.00338070
47Pertussis_Homo sapiens_hsa051330.98853306
48Pathways in cancer_Homo sapiens_hsa052000.98512060
49MicroRNAs in cancer_Homo sapiens_hsa052060.96363390
50Phototransduction_Homo sapiens_hsa047440.95924694
51Thyroid cancer_Homo sapiens_hsa052160.95058634
52p53 signaling pathway_Homo sapiens_hsa041150.94675746
53TNF signaling pathway_Homo sapiens_hsa046680.93405820
54Chemical carcinogenesis_Homo sapiens_hsa052040.91710866
55Wnt signaling pathway_Homo sapiens_hsa043100.88652247
56Sphingolipid metabolism_Homo sapiens_hsa006000.87681086
57Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.87678057
58Insulin signaling pathway_Homo sapiens_hsa049100.86564823
59Chronic myeloid leukemia_Homo sapiens_hsa052200.86030738
60Tyrosine metabolism_Homo sapiens_hsa003500.84787123
61Dorso-ventral axis formation_Homo sapiens_hsa043200.83929343
62Pancreatic cancer_Homo sapiens_hsa052120.83283302
63Leukocyte transendothelial migration_Homo sapiens_hsa046700.81041565
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.79780529
65Choline metabolism in cancer_Homo sapiens_hsa052310.79050782
66Inositol phosphate metabolism_Homo sapiens_hsa005620.78357177
67Jak-STAT signaling pathway_Homo sapiens_hsa046300.77955955
68Dilated cardiomyopathy_Homo sapiens_hsa054140.77322469
69Staphylococcus aureus infection_Homo sapiens_hsa051500.77097508
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73420085
71Hepatitis C_Homo sapiens_hsa051600.72625508
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72449971
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.72448595
74Ras signaling pathway_Homo sapiens_hsa040140.72052547
75Renin secretion_Homo sapiens_hsa049240.71653940
76Pancreatic secretion_Homo sapiens_hsa049720.70475542
77Endocytosis_Homo sapiens_hsa041440.70093944
78TGF-beta signaling pathway_Homo sapiens_hsa043500.69132522
79Prion diseases_Homo sapiens_hsa050200.68436193
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67013772
81Shigellosis_Homo sapiens_hsa051310.66674442
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.66148197
83Rap1 signaling pathway_Homo sapiens_hsa040150.66075588
84Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.65225187
85Retinol metabolism_Homo sapiens_hsa008300.63290430
86Estrogen signaling pathway_Homo sapiens_hsa049150.63252029
87Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.62940342
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62656930
89Platelet activation_Homo sapiens_hsa046110.62656609
90PI3K-Akt signaling pathway_Homo sapiens_hsa041510.61773248
91HTLV-I infection_Homo sapiens_hsa051660.60814043
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.59999093
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.59604205
94Apoptosis_Homo sapiens_hsa042100.57770699
95Renal cell carcinoma_Homo sapiens_hsa052110.57734482
96Osteoclast differentiation_Homo sapiens_hsa043800.57721663
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57012726
98beta-Alanine metabolism_Homo sapiens_hsa004100.56925291
99Glioma_Homo sapiens_hsa052140.56395197
100Endometrial cancer_Homo sapiens_hsa052130.56348935
101Malaria_Homo sapiens_hsa051440.56182752
102ErbB signaling pathway_Homo sapiens_hsa040120.54666757
103Insulin resistance_Homo sapiens_hsa049310.53929152
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.52266065
105Serotonergic synapse_Homo sapiens_hsa047260.51841048
106Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51712893
107Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50757122
108Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50728909
109Glycerolipid metabolism_Homo sapiens_hsa005610.49926692
110Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49173937
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.48752131
112Long-term potentiation_Homo sapiens_hsa047200.48695476
113Long-term depression_Homo sapiens_hsa047300.48387883
114Prolactin signaling pathway_Homo sapiens_hsa049170.48072815
115Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47663553
116Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47498368
117NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47458982
118Gastric acid secretion_Homo sapiens_hsa049710.45298742
119PPAR signaling pathway_Homo sapiens_hsa033200.45109909
120Non-small cell lung cancer_Homo sapiens_hsa052230.44139534
121Influenza A_Homo sapiens_hsa051640.43965057
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43954587
123Salmonella infection_Homo sapiens_hsa051320.43771904
124MAPK signaling pathway_Homo sapiens_hsa040100.42720925
125Circadian rhythm_Homo sapiens_hsa047100.41850158
126Tuberculosis_Homo sapiens_hsa051520.41741538
127Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41052979
128Leishmaniasis_Homo sapiens_hsa051400.40844605
129Melanoma_Homo sapiens_hsa052180.40245653
130Glucagon signaling pathway_Homo sapiens_hsa049220.38386983
131Lysosome_Homo sapiens_hsa041420.37718074
132Galactose metabolism_Homo sapiens_hsa000520.36949568

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