KRT13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peptide cross-linking (GO:0018149)9.07742985
2citrulline biosynthetic process (GO:0019240)7.55008000
3response to phenylpropanoid (GO:0080184)7.18350159
4regulation of toll-like receptor 4 signaling pathway (GO:0034143)7.08718108
5sarcoplasmic reticulum calcium ion transport (GO:0070296)7.00404291
6establishment of planar polarity (GO:0001736)6.96848893
7establishment of tissue polarity (GO:0007164)6.96848893
8regulation of keratinocyte differentiation (GO:0045616)6.82748281
9response to vitamin A (GO:0033189)6.67866118
10apical protein localization (GO:0045176)6.32337329
11eyelid development in camera-type eye (GO:0061029)6.28916041
12regulation of skeletal muscle contraction (GO:0014819)6.22576681
13hair follicle morphogenesis (GO:0031069)6.21020304
14planar cell polarity pathway involved in neural tube closure (GO:0090179)6.20848003
15ectoderm development (GO:0007398)6.04328994
16regulation of ruffle assembly (GO:1900027)6.00423076
17keratinocyte proliferation (GO:0043616)5.87022464
18regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)5.79881081
19keratinocyte differentiation (GO:0030216)5.76401786
20regulation of relaxation of muscle (GO:1901077)5.31638998
21citrulline metabolic process (GO:0000052)5.15583554
22coronary vasculature morphogenesis (GO:0060977)5.15445254
23regulation of cardioblast proliferation (GO:0003264)5.07744370
24regulation of secondary heart field cardioblast proliferation (GO:0003266)5.07744370
25lymph vessel development (GO:0001945)5.00324339
26skeletal muscle contraction (GO:0003009)4.96341146
27innate immune response in mucosa (GO:0002227)4.95530508
28asymmetric protein localization (GO:0008105)4.93148282
29muscle organ morphogenesis (GO:0048644)4.90669016
30purine nucleotide salvage (GO:0032261)4.72104086
31keratinocyte development (GO:0003334)4.69894781
32muscle filament sliding (GO:0030049)4.60526536
33actin-myosin filament sliding (GO:0033275)4.60526536
34localization within membrane (GO:0051668)4.59597619
35gap junction assembly (GO:0016264)4.59567496
36surfactant homeostasis (GO:0043129)4.51123549
37long-chain fatty acid biosynthetic process (GO:0042759)4.50988512
38linoleic acid metabolic process (GO:0043651)4.39831138
39regulation of skeletal muscle cell differentiation (GO:2001014)4.38481568
40epithelial cell differentiation (GO:0030855)4.36610906
41positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.35539216
42membrane raft organization (GO:0031579)4.33532362
43hair cell differentiation (GO:0035315)4.26964930
44peptidyl-arginine modification (GO:0018195)4.23789571
45regulation of epidermal cell differentiation (GO:0045604)4.11629756
46cellular response to epidermal growth factor stimulus (GO:0071364)4.04889189
47outer ear morphogenesis (GO:0042473)3.98651451
48epidermal cell differentiation (GO:0009913)3.98148222
49tooth mineralization (GO:0034505)3.96719478
50leukocyte aggregation (GO:0070486)3.94356912
51mucosal immune response (GO:0002385)3.91957867
52negative regulation of calcium ion transmembrane transport (GO:1903170)3.83824919
53negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.83824919
54actin-mediated cell contraction (GO:0070252)3.82570440
55negative regulation of toll-like receptor signaling pathway (GO:0034122)3.81054086
56positive regulation of epidermal cell differentiation (GO:0045606)3.80089736
57negative regulation of cell-substrate adhesion (GO:0010812)3.74648226
58Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.71765649
59detection of bacterium (GO:0016045)3.71687150
60bundle of His cell to Purkinje myocyte communication (GO:0086069)3.69697543
61organ or tissue specific immune response (GO:0002251)3.69275786
62positive regulation of vesicle fusion (GO:0031340)3.68334764
63cellular response to glucocorticoid stimulus (GO:0071385)3.64124318
64embryonic viscerocranium morphogenesis (GO:0048703)3.62717638
65chemical homeostasis within a tissue (GO:0048875)3.62501779
66epithelial cell-cell adhesion (GO:0090136)3.59402909
67hemidesmosome assembly (GO:0031581)3.58144518
68regulation of establishment of planar polarity (GO:0090175)3.57658929
69chronic inflammatory response (GO:0002544)3.57372548
70positive regulation of Cdc42 GTPase activity (GO:0043089)3.54977517
71sequestering of metal ion (GO:0051238)3.53149626
72positive regulation of epidermis development (GO:0045684)3.52718677
73cellular response to corticosteroid stimulus (GO:0071384)3.50292037
74desmosome organization (GO:0002934)3.49468837
75cochlea morphogenesis (GO:0090103)3.49006414
76hypotonic response (GO:0006971)3.45463057
77lipoxygenase pathway (GO:0019372)3.44579170
78establishment of skin barrier (GO:0061436)3.43943622
79gas transport (GO:0015669)3.43921957
80mucosal-associated lymphoid tissue development (GO:0048537)3.41406864
81Peyers patch development (GO:0048541)3.41406864
82negative regulation of keratinocyte proliferation (GO:0010839)3.35896491
83negative regulation of acute inflammatory response (GO:0002674)3.35665476
84epithelium development (GO:0060429)3.34754405
85O-glycan processing (GO:0016266)3.32425006
86negative regulation of thymocyte apoptotic process (GO:0070244)3.32297893
87hair cycle (GO:0042633)3.31570628
88molting cycle (GO:0042303)3.31570628
89response to epidermal growth factor (GO:0070849)3.31273157
90negative regulation of stress fiber assembly (GO:0051497)3.30675164
91hair cycle process (GO:0022405)3.30486142
92molting cycle process (GO:0022404)3.30486142
93detection of other organism (GO:0098543)3.30160962
94negative regulation of cell-cell adhesion (GO:0022408)3.29458096
95regulation of water loss via skin (GO:0033561)3.26870663
96plasma membrane repair (GO:0001778)3.25728244
97muscle cell fate commitment (GO:0042693)3.20622141
98histamine secretion (GO:0001821)3.20534634
99actin filament-based movement (GO:0030048)3.18713347
100negative regulation of bone mineralization (GO:0030502)3.18140261
101leukocyte migration involved in inflammatory response (GO:0002523)3.17245434
102one-carbon compound transport (GO:0019755)3.16552916
103regulation of penile erection (GO:0060405)3.15131899
104response to vitamin E (GO:0033197)3.12795097
105myotube differentiation (GO:0014902)3.12605079
106regulation of endothelial cell chemotaxis (GO:2001026)3.11249951
107multicellular organismal water homeostasis (GO:0050891)3.10635728
108polarized epithelial cell differentiation (GO:0030859)3.05742234
109regulation of germinal center formation (GO:0002634)3.02473969
110creatine metabolic process (GO:0006600)3.02163140
111ethanol oxidation (GO:0006069)3.01495806
112positive regulation of myotube differentiation (GO:0010831)3.01172790
113negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.00878839
114positive regulation of protein depolymerization (GO:1901881)2.98429611
115non-canonical Wnt signaling pathway (GO:0035567)2.94165901
116regulation of epidermis development (GO:0045682)2.93713611
117negative regulation of interferon-gamma production (GO:0032689)2.92417838
118negative regulation of biomineral tissue development (GO:0070168)2.90816602
119ventricular cardiac muscle cell action potential (GO:0086005)2.89381384
120positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.88797147
121positive regulation of endothelial cell differentiation (GO:0045603)2.86726215
122positive regulation of monocyte chemotaxis (GO:0090026)2.86096980
123endosome organization (GO:0007032)2.85877040
124intestinal epithelial cell development (GO:0060576)2.84421698
125skeletal muscle adaptation (GO:0043501)2.83488139
126atrioventricular valve morphogenesis (GO:0003181)2.82033652
127ethanol metabolic process (GO:0006067)2.81334913
128striated muscle contraction (GO:0006941)2.77355580
129embryonic camera-type eye development (GO:0031076)2.75901697
1304-hydroxyproline metabolic process (GO:0019471)2.75087601
131regulation of Cdc42 GTPase activity (GO:0043088)2.72921171
132regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.70895463
133regulation of natural killer cell differentiation (GO:0032823)2.70651073
134mature B cell differentiation involved in immune response (GO:0002313)2.66649018
135renal absorption (GO:0070293)2.66223921
136epithelial cell differentiation involved in prostate gland development (GO:0060742)2.65727878
137sarcomere organization (GO:0045214)2.65445734
138regulation of endothelial cell differentiation (GO:0045601)2.63999545
139cranial nerve morphogenesis (GO:0021602)2.63652822
140regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.62829411
141water homeostasis (GO:0030104)2.56043221
142positive regulation of T cell differentiation in thymus (GO:0033089)2.53694438
143outflow tract septum morphogenesis (GO:0003148)2.53583377
144myofibril assembly (GO:0030239)2.53304642
145regulation of pH (GO:0006885)2.52495926
146retinoic acid metabolic process (GO:0042573)2.52066832
147skeletal muscle fiber development (GO:0048741)2.52003536
148epidermis development (GO:0008544)2.51374179
149regulation of neuron projection regeneration (GO:0070570)2.49459985
150regulation of axon regeneration (GO:0048679)2.49459985
151negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.48688545
152negative regulation of ion transmembrane transporter activity (GO:0032413)2.48204627
153primary alcohol catabolic process (GO:0034310)2.48098809
154thyroid hormone generation (GO:0006590)2.48021759
155protein localization to endosome (GO:0036010)2.47929634
156intermediate filament organization (GO:0045109)2.46674924
157tricarboxylic acid cycle (GO:0006099)2.46616840
158polyol transport (GO:0015791)2.46366075
159face development (GO:0060324)2.45718915
160regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.45196504
161regulation of calcium ion transmembrane transport (GO:1903169)2.45068253
162regulation of calcium ion transmembrane transporter activity (GO:1901019)2.45068253
163positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.44912500
164lateral sprouting from an epithelium (GO:0060601)2.43458049
165regulation of keratinocyte proliferation (GO:0010837)2.42308451
166hydrogen peroxide metabolic process (GO:0042743)2.41898119
167* cellular response to retinoic acid (GO:0071300)2.41836664
168negative regulation of cell fate specification (GO:0009996)2.41596701
169negative regulation of B cell apoptotic process (GO:0002903)2.41309506
170adenosine metabolic process (GO:0046085)2.40489795
171activation of Rac GTPase activity (GO:0032863)2.39988652
172positive regulation of skeletal muscle tissue development (GO:0048643)2.39901526
173wound healing (GO:0042060)2.38829244
174histamine transport (GO:0051608)2.37451162
175keratinization (GO:0031424)18.1729882
176negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)12.0165520
177cell wall macromolecule metabolic process (GO:0044036)11.3278621
178cell wall macromolecule catabolic process (GO:0016998)11.3278621
179transepithelial transport (GO:0070633)10.4297992

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.64304892
2ZNF652_21678463_ChIP-ChIP_ZR75-1_Human6.29470878
3TRIM28_21343339_ChIP-Seq_HEK293_Human4.07445050
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.99424384
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.51951873
6RARG_19884340_ChIP-ChIP_MEFs_Mouse3.15139646
7GATA1_22025678_ChIP-Seq_K562_Human2.50103539
8ESR1_20079471_ChIP-ChIP_T-47D_Human2.21543148
9CLOCK_20551151_ChIP-Seq_293T_Human2.09870689
10CDX2_19796622_ChIP-Seq_MESCs_Mouse2.09711045
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.04701727
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.02266725
13ZNF263_19887448_ChIP-Seq_K562_Human1.90579452
14* TP63_22573176_ChIP-Seq_HFKS_Human1.86914313
15STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.79500418
16TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.68044135
17BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.68039959
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.65915103
19* ESR2_21235772_ChIP-Seq_MCF-7_Human1.65421291
20CTCF_27219007_Chip-Seq_Bcells_Human1.65290734
21* ESR1_21235772_ChIP-Seq_MCF-7_Human1.63473309
22CJUN_26792858_Chip-Seq_BT549_Human1.58432863
23FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.52666130
24P63_26484246_Chip-Seq_KERATINOCYTES_Human1.51840493
25CTCF_20526341_ChIP-Seq_ESCs_Human1.51112322
26* SOX2_20726797_ChIP-Seq_SW620_Human1.45685766
27TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38473088
28* RACK7_27058665_Chip-Seq_MCF-7_Human1.37783157
29* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.36917238
30STAT6_21828071_ChIP-Seq_BEAS2B_Human1.36571074
31RXR_22158963_ChIP-Seq_LIVER_Mouse1.35832019
32* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.34215924
33* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.34215924
34TBX20_22328084_ChIP-Seq_HEART_Mouse1.29660827
35TBX20_22080862_ChIP-Seq_HEART_Mouse1.29660827
36SA1_27219007_Chip-Seq_Bcells_Human1.29471136
37* SMC4_20622854_ChIP-Seq_HELA_Human1.26611753
38ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.24515131
39* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.22724144
40SOX9_24532713_ChIP-Seq_HFSC_Mouse1.22416888
41SA1_27219007_Chip-Seq_ERYTHROID_Human1.22293390
42ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21277417
43PPARA_22158963_ChIP-Seq_LIVER_Mouse1.20383951
44P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.20372550
45GATA6_25053715_ChIP-Seq_YYC3_Human1.17856234
46FOXO3_23340844_ChIP-Seq_DLD1_Human1.17756365
47AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.17415485
48E2F1_20622854_ChIP-Seq_HELA_Human1.16355682
49LXR_22158963_ChIP-Seq_LIVER_Mouse1.15819444
50TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14864509
51BP1_19119308_ChIP-ChIP_Hs578T_Human1.13645185
52NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.12473854
53SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.12463994
54SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.12229981
55TCF4_18268006_ChIP-ChIP_LS174T_Human1.11800003
56HIF1A_21447827_ChIP-Seq_MCF-7_Human1.10892166
57NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10695828
58NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10695828
59ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10165032
60* BCOR_27268052_Chip-Seq_Bcells_Human1.09881451
61* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.09671335
62RUNX1_27514584_Chip-Seq_MCF-7_Human1.08414022
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08085414
64EGR1_19032775_ChIP-ChIP_M12_Human1.07285075
65RXR_22108803_ChIP-Seq_LS180_Human1.07194893
66PPAR_26484153_Chip-Seq_NCI-H1993_Human1.07162110
67CEBPB_22108803_ChIP-Seq_LS180_Human1.06789629
68PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05792146
69CREB1_26743006_Chip-Seq_LNCaP_Human1.05652020
70* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05337510
71SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05226130
72GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.04272075
73RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02553877
74EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01999720
75* GATA3_24758297_ChIP-Seq_MCF-7_Human1.01418399
76IRF8_21731497_ChIP-ChIP_J774_Mouse1.01034826
77KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99728128
78VDR_22108803_ChIP-Seq_LS180_Human0.98660914
79GATA2_21666600_ChIP-Seq_HMVEC_Human0.98376734
80CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.97921920
81EP300_21415370_ChIP-Seq_HL-1_Mouse0.97340842
82SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97176884
83LXR_22292898_ChIP-Seq_THP-1_Human0.95116430
84CDX2_20551321_ChIP-Seq_CACO-2_Human0.94969369
85AHR_22903824_ChIP-Seq_MCF-7_Human0.94952541
86GATA1_19941826_ChIP-Seq_K562_Human0.94948771
87KLF5_25053715_ChIP-Seq_YYC3_Human0.94870661
88ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93744350
89TP53_20018659_ChIP-ChIP_R1E_Mouse0.92548697
90DNAJC2_21179169_ChIP-ChIP_NT2_Human0.91459644
91BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.91085421
92SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90967774
93GATA6_21074721_ChIP-Seq_CACO-2_Human0.90815502
94RAD21_21589869_ChIP-Seq_MESCs_Mouse0.90746424
95P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90580130
96MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.90222270
97TP63_23658742_ChIP-Seq_EP156T_Human0.89871280
98SOX3_22085726_ChIP-Seq_NPCs_Mouse0.89530128
99GATA4_25053715_ChIP-Seq_YYC3_Human0.89061842
100FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.88970357
101SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.87814341
102HTT_18923047_ChIP-ChIP_STHdh_Human0.87185351
103* ERG_20517297_ChIP-Seq_VCAP_Human0.87028103
104YY1_22570637_ChIP-Seq_MALME-3M_Human0.86945466
105RBPJ_21746931_ChIP-Seq_IB4_Human0.86943697
106GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.86387361
107* FOXH1_21741376_ChIP-Seq_ESCs_Human0.86367528
108SUZ12_27294783_Chip-Seq_ESCs_Mouse0.85480424
109KDM2B_26808549_Chip-Seq_SUP-B15_Human0.85326764
110TP53_16413492_ChIP-PET_HCT116_Human0.84856020
111PHF8_20622854_ChIP-Seq_HELA_Human0.84796356
112JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84729212
113* ELK3_25401928_ChIP-Seq_HUVEC_Human0.83306677
114PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.82620223
115UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.82565104
116STAT3_1855785_ChIP-Seq_MESCs_Mouse0.82482330
117ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.82376671
118RXRA_24833708_ChIP-Seq_LIVER_Mouse0.82227833
119MTF2_20144788_ChIP-Seq_MESCs_Mouse0.82120473
120KDM2B_26808549_Chip-Seq_K562_Human0.82032178
121ATF3_27146783_Chip-Seq_COLON_Human0.81783847
122NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.81544634
123ERG_21242973_ChIP-ChIP_JURKAT_Human0.81183593
124STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.81102670
125BCAT_22108803_ChIP-Seq_LS180_Human0.80706049
126GATA2_19941826_ChIP-Seq_K562_Human0.80568867
127KDM2B_26808549_Chip-Seq_DND41_Human0.80238357
128TCF7_22412390_ChIP-Seq_EML_Mouse0.79793613
129SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.79462272
130JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.78714381
131RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.78646027
132BCL6_27268052_Chip-Seq_Bcells_Human0.78562635
133ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.78407904
134KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.78326466
135FLI1_21867929_ChIP-Seq_CD8_Mouse0.77307702
136JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77249967
137RNF2_18974828_ChIP-Seq_MESCs_Mouse0.76627473
138EZH2_18974828_ChIP-Seq_MESCs_Mouse0.76627473
139P68_20966046_ChIP-Seq_HELA_Human0.75859455
140CTCF_21964334_ChIP-Seq_BJAB-B_Human0.75362431

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation7.30646020
2MP0002234_abnormal_pharynx_morphology4.89464956
3MP0002796_impaired_skin_barrier4.59896744
4MP0005275_abnormal_skin_tensile4.31107974
5MP0000467_abnormal_esophagus_morphology4.05320584
6MP0000751_myopathy3.77639350
7MP0000762_abnormal_tongue_morphology3.47478380
8MP0010234_abnormal_vibrissa_follicle3.40408424
9MP0003646_muscle_fatigue3.20617286
10MP0000749_muscle_degeneration2.91450623
11MP0005501_abnormal_skin_physiology2.54111779
12MP0001958_emphysema2.52438826
13MP0000566_synostosis2.46116744
14MP0002837_dystrophic_cardiac_calcinosis2.29888864
15MP0002095_abnormal_skin_pigmentation2.28160050
16MP0001879_abnormal_lymphatic_vessel2.27880984
17MP0000371_diluted_coat_color2.21933481
18MP0002138_abnormal_hepatobiliary_system2.19657330
19MP0001243_abnormal_dermal_layer2.18919848
20MP0003705_abnormal_hypodermis_morpholog2.18287879
21MP0003878_abnormal_ear_physiology2.13637378
22MP0005377_hearing/vestibular/ear_phenot2.13637378
23MP0000747_muscle_weakness2.03907199
24MP0004130_abnormal_muscle_cell1.98734393
25MP0004782_abnormal_surfactant_physiolog1.98201974
26MP0009053_abnormal_anal_canal1.97214653
27MP0004185_abnormal_adipocyte_glucose1.95702100
28MP0009697_abnormal_copulation1.95449708
29MP0004885_abnormal_endolymph1.94654962
30MP0000678_abnormal_parathyroid_gland1.93307366
31MP0000759_abnormal_skeletal_muscle1.90027109
32MP0002106_abnormal_muscle_physiology1.86952019
33MP0004145_abnormal_muscle_electrophysio1.86824670
34MP0004264_abnormal_extraembryonic_tissu1.78687096
35MP0003252_abnormal_bile_duct1.77026813
36MP0004087_abnormal_muscle_fiber1.71534874
37MP0004036_abnormal_muscle_relaxation1.69199131
38MP0000733_abnormal_muscle_development1.68729915
39MP0003566_abnormal_cell_adhesion1.68527236
40MP0003806_abnormal_nucleotide_metabolis1.63107158
41MP0002332_abnormal_exercise_endurance1.57749858
42MP0001851_eye_inflammation1.53255496
43MP0005167_abnormal_blood-brain_barrier1.49860324
44MP0000750_abnormal_muscle_regeneration1.48820685
45MP0005369_muscle_phenotype1.47507183
46MP0000470_abnormal_stomach_morphology1.46258057
47MP0003950_abnormal_plasma_membrane1.46062516
48MP0005620_abnormal_muscle_contractility1.37614841
49MP0010030_abnormal_orbit_morphology1.32204505
50MP0004084_abnormal_cardiac_muscle1.28127839
51MP0010368_abnormal_lymphatic_system1.26550452
52MP0001216_abnormal_epidermal_layer1.25061301
53MP0004272_abnormal_basement_membrane1.22542174
54MP0002269_muscular_atrophy1.19826560
55MP0000465_gastrointestinal_hemorrhage1.19674749
56MP0002972_abnormal_cardiac_muscle1.15820234
57MP0010771_integument_phenotype1.15693659
58MP0003191_abnormal_cellular_cholesterol1.13487632
59MP0005666_abnormal_adipose_tissue1.13072377
60MP0003453_abnormal_keratinocyte_physiol1.12906191
61MP0010678_abnormal_skin_adnexa1.11627724
62MP0002909_abnormal_adrenal_gland1.11196353
63MP0002249_abnormal_larynx_morphology1.10240611
64MP0001765_abnormal_ion_homeostasis1.06376613
65MP0005330_cardiomyopathy1.05875167
66MP0005266_abnormal_metabolism1.05043923
67MP0002139_abnormal_hepatobiliary_system1.04123788
68MP0000579_abnormal_nail_morphology1.04057958
69MP0001177_atelectasis1.02825790
70MP0000343_altered_response_to1.00843789
71MP0004947_skin_inflammation0.97174561
72MP0005385_cardiovascular_system_phenoty0.94803778
73MP0001544_abnormal_cardiovascular_syste0.94803778
74MP0000647_abnormal_sebaceous_gland0.94173403
75MP0008875_abnormal_xenobiotic_pharmacok0.92096251
76MP0002127_abnormal_cardiovascular_syste0.90974777
77MP0006138_congestive_heart_failure0.90313373
78MP0005503_abnormal_tendon_morphology0.89081073
79MP0002075_abnormal_coat/hair_pigmentati0.88926909
80MP0002254_reproductive_system_inflammat0.87763859
81MP0004484_altered_response_of0.86394527
82MP0000537_abnormal_urethra_morphology0.85557538
83MP0005409_darkened_coat_color0.84528972
84MP0005083_abnormal_biliary_tract0.83210669
85MP0003221_abnormal_cardiomyocyte_apopto0.83182870
86MP0003315_abnormal_perineum_morphology0.82939962
87MP0002133_abnormal_respiratory_system0.81898332
88MP0005388_respiratory_system_phenotype0.81898332
89MP0001191_abnormal_skin_condition0.79443089
90MP0010630_abnormal_cardiac_muscle0.78033811
91MP0002060_abnormal_skin_morphology0.75746251
92MP0008438_abnormal_cutaneous_collagen0.75087364
93MP0000613_abnormal_salivary_gland0.73792694
94MP0006036_abnormal_mitochondrial_physio0.71981040
95MP0006054_spinal_hemorrhage0.71421640
96MP0010352_gastrointestinal_tract_polyps0.71251886
97MP0000383_abnormal_hair_follicle0.71241811
98MP0000427_abnormal_hair_cycle0.70324933
99MP0005023_abnormal_wound_healing0.69967394
100MP0002098_abnormal_vibrissa_morphology0.69863750
101MP0000049_abnormal_middle_ear0.69731860
102MP0004270_analgesia0.69129718
103MP0005375_adipose_tissue_phenotype0.68134195
104MP0009780_abnormal_chondrocyte_physiolo0.66655358
105MP0003638_abnormal_response/metabolism_0.66489733
106MP0000367_abnormal_coat/_hair0.66301936
107MP0003075_altered_response_to0.65878188
108MP0003329_amyloid_beta_deposits0.65029915
109MP0009931_abnormal_skin_appearance0.64326015
110MP0001186_pigmentation_phenotype0.63330056
111MP0004215_abnormal_myocardial_fiber0.60301334
112MP0010386_abnormal_urinary_bladder0.60161456
113MP0005636_abnormal_mineral_homeostasis0.59580962
114MP0001299_abnormal_eye_distance/0.58750929
115MP0005165_increased_susceptibility_to0.58168555
116MP0008789_abnormal_olfactory_epithelium0.56222223
117MP0002111_abnormal_tail_morphology0.55738197
118MP0004233_abnormal_muscle_weight0.54695201
119MP0001849_ear_inflammation0.52940722
120MP0001943_abnormal_respiration0.52701766
121MP0005193_abnormal_anterior_eye0.52541189
122MP0000377_abnormal_hair_follicle0.52525533
123MP0001784_abnormal_fluid_regulation0.48899433
124MP0003941_abnormal_skin_development0.48709464
125MP0001340_abnormal_eyelid_morphology0.48145134
126MP0003011_delayed_dark_adaptation0.47122064
127MP0009643_abnormal_urine_homeostasis0.46467973
128MP0004381_abnormal_hair_follicle0.45479264
129MP0000681_abnormal_thyroid_gland0.44960776
130MP0003755_abnormal_palate_morphology0.42177532
131MP0004019_abnormal_vitamin_homeostasis0.42034072
132MP0003937_abnormal_limbs/digits/tail_de0.38792721
133MP0005499_abnormal_olfactory_system0.37599403
134MP0005394_taste/olfaction_phenotype0.37599403
135MP0002136_abnormal_kidney_physiology0.35972221
136MP0002877_abnormal_melanocyte_morpholog0.35548602
137MP0008569_lethality_at_weaning0.32146860
138MP0000685_abnormal_immune_system0.31636614
139MP0001756_abnormal_urination0.30830017
140MP0003724_increased_susceptibility_to0.30646758
141MP0003763_abnormal_thymus_physiology0.28919519
142MP0001270_distended_abdomen0.28885746
143MP0000477_abnormal_intestine_morphology0.28797546
144MP0001485_abnormal_pinna_reflex0.26669344
145MP0000858_altered_metastatic_potential0.26642921
146MP0005451_abnormal_body_composition0.24307229
147MP0003828_pulmonary_edema0.22357172
148MP0002089_abnormal_postnatal_growth/wei0.21812638
149MP0009333_abnormal_splenocyte_physiolog0.21781263
150MP0004197_abnormal_fetal_growth/weight/0.21620018
151MP0005670_abnormal_white_adipose0.19091751
152MP0002166_altered_tumor_susceptibility0.18999510
153MP0000627_abnormal_mammary_gland0.18805318
154MP0000462_abnormal_digestive_system0.18377407
155MP0002006_tumorigenesis0.17650374
156MP0002009_preneoplasia0.17378315

Predicted human phenotypes

RankGene SetZ-score
1Erythroderma (HP:0001019)7.63295476
2Palmoplantar hyperkeratosis (HP:0000972)6.94732398
3Abnormality of nail color (HP:0100643)6.88491196
4Lip pit (HP:0100267)6.63111607
5Palmar hyperkeratosis (HP:0010765)6.58004515
6Distal arthrogryposis (HP:0005684)6.25780966
7Plantar hyperkeratosis (HP:0007556)5.72256011
8Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.70257817
9Muscle fiber inclusion bodies (HP:0100299)5.69756039
10Exercise-induced myalgia (HP:0003738)5.56687193
11Alopecia of scalp (HP:0002293)5.39792951
12Fragile nails (HP:0001808)5.35338119
13Nemaline bodies (HP:0003798)5.17377278
14Round ear (HP:0100830)5.14978257
15Abnormality of the salivary glands (HP:0010286)5.01651082
16Hypotrichosis (HP:0001006)4.92817115
17Exercise-induced muscle cramps (HP:0003710)4.61140533
18Type 1 muscle fiber predominance (HP:0003803)4.59620623
19Ulnar deviation of the wrist (HP:0003049)4.56707778
20Abnormality of secondary sexual hair (HP:0009888)4.55244784
21Abnormality of the axillary hair (HP:0100134)4.55244784
22Increased connective tissue (HP:0009025)4.51180034
23Difficulty running (HP:0009046)4.33076650
24Muscle hypertrophy of the lower extremities (HP:0008968)4.18118294
25Right ventricular cardiomyopathy (HP:0011663)4.13479237
26Nail dystrophy (HP:0008404)4.10234244
27Calf muscle hypertrophy (HP:0008981)4.07872351
28Absent phalangeal crease (HP:0006109)4.07323261
29Myopathic facies (HP:0002058)4.05997114
30Erythema (HP:0010783)4.00121816
31Hyporeflexia of lower limbs (HP:0002600)3.93581218
32Absent eyelashes (HP:0000561)3.92972995
33Pustule (HP:0200039)3.92060781
34Calcaneovalgus deformity (HP:0001848)3.92017919
35Myoglobinuria (HP:0002913)3.91715251
36Muscle fiber splitting (HP:0003555)3.88702160
37Autoimmune thrombocytopenia (HP:0001973)3.78627083
38Increased IgE level (HP:0003212)3.74297022
39Unilateral renal agenesis (HP:0000122)3.70178872
40Thick nail (HP:0001805)3.65348227
41Rimmed vacuoles (HP:0003805)3.50891883
42Mesangial abnormality (HP:0001966)3.50690377
43Sparse scalp hair (HP:0002209)3.49240068
44Deformed tarsal bones (HP:0008119)3.44779166
45Increased variability in muscle fiber diameter (HP:0003557)3.40369959
46Abnormal finger flexion creases (HP:0006143)3.37775839
47Popliteal pterygium (HP:0009756)3.35219883
48Hyperactive renin-angiotensin system (HP:0000841)3.28088833
49Abnormality of skeletal muscle fiber size (HP:0012084)3.27103895
50Absent hair (HP:0002298)3.26502619
51Congenital malformation of the right heart (HP:0011723)3.25003046
52Double outlet right ventricle (HP:0001719)3.25003046
53Acanthosis nigricans (HP:0000956)3.24405741
54Autoimmune hemolytic anemia (HP:0001890)3.20777896
55Sparse eyelashes (HP:0000653)3.14458408
56Hypohidrosis (HP:0000966)3.12148430
57Distal lower limb muscle weakness (HP:0009053)3.09825276
58Abnormality of small intestinal villus morphology (HP:0011472)3.01543278
59Villous atrophy (HP:0011473)3.01543278
60Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.99379713
61Brittle hair (HP:0002299)2.96610811
62Congenital ichthyosiform erythroderma (HP:0007431)2.93766675
63Abnormality of the parathyroid morphology (HP:0011766)2.89191185
64Nasal polyposis (HP:0100582)2.86263197
65EMG: myopathic abnormalities (HP:0003458)2.80800920
66Abnormality of the calf musculature (HP:0001430)2.80517451
67Hypoplastic labia majora (HP:0000059)2.79297541
68Cholelithiasis (HP:0001081)2.72117272
69Muscle stiffness (HP:0003552)2.70801117
70Dehydration (HP:0001944)2.69735251
71Myotonia (HP:0002486)2.68823493
72Malnutrition (HP:0004395)2.65762825
73Paralysis (HP:0003470)2.65378512
74Blepharitis (HP:0000498)2.65179591
75Cupped ribs (HP:0000887)2.65139761
76Abnormality of the aortic arch (HP:0012303)2.63504529
77Gangrene (HP:0100758)2.60622963
78Frequent falls (HP:0002359)2.58911575
79Difficulty climbing stairs (HP:0003551)2.58871587
80Amniotic constriction ring (HP:0009775)2.58144334
81Abnormality of placental membranes (HP:0011409)2.58144334
82Distal lower limb amyotrophy (HP:0008944)2.56971137
83Areflexia of lower limbs (HP:0002522)2.55723031
84Abnormality of the labia majora (HP:0012881)2.55436479
85Parakeratosis (HP:0001036)2.54941882
86Hyperkalemia (HP:0002153)2.52171573
87Abnormality of the calcaneus (HP:0008364)2.51642959
88Hyperthyroidism (HP:0000836)2.50639735
89Onycholysis (HP:0001806)2.49916607
90Neck muscle weakness (HP:0000467)2.46706783
91Rhabdomyolysis (HP:0003201)2.46539963
92Abnormal gallbladder morphology (HP:0012437)2.46286107
93Urticaria (HP:0001025)2.45375100
94Interstitial pulmonary disease (HP:0006530)2.43514697
95Pili torti (HP:0003777)2.38885476
96Multifactorial inheritance (HP:0001426)2.35266922
97Facial diplegia (HP:0001349)2.33197937
98Abnormal hair laboratory examination (HP:0003328)2.31493477
99Hypoplastic left heart (HP:0004383)2.29227429
100Abnormality of B cell number (HP:0010975)2.28472459
101B lymphocytopenia (HP:0010976)2.28472459
102Trismus (HP:0000211)2.27707340
103Milia (HP:0001056)2.26860281
104Polycythemia (HP:0001901)2.26672828
105Tetany (HP:0001281)2.18926914
106Woolly hair (HP:0002224)2.17166214
107Oligodontia (HP:0000677)2.17038249
108Ridged nail (HP:0001807)2.16119202
109Recurrent corneal erosions (HP:0000495)2.12223682
110Furrowed tongue (HP:0000221)2.11785207
111Abnormal blistering of the skin (HP:0008066)2.11434164
112Scapular winging (HP:0003691)2.10697638
113Chronic bronchitis (HP:0004469)2.09077475
114Gout (HP:0001997)2.06320551
115Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.06242051
116Autoamputation (HP:0001218)2.06211335
117Hypoplastic ischia (HP:0003175)2.04963403
118Hematochezia (HP:0002573)2.01279405
119Long clavicles (HP:0000890)2.00530904
120Abnormality of the distal phalanges of the toes (HP:0010182)2.00525233
121Oral leukoplakia (HP:0002745)13.3235079
122Corneal erosion (HP:0200020)1.99953942
123Lower limb amyotrophy (HP:0007210)1.98948741
124Lack of skin elasticity (HP:0100679)1.96582596
125Seborrheic dermatitis (HP:0001051)1.93591384
126Decreased circulating renin level (HP:0003351)1.92328473
127Exotropia (HP:0000577)1.90867975
128Elbow flexion contracture (HP:0002987)1.89192597
129Ectropion (HP:0000656)1.86934190
130Skin pits (HP:0100276)1.86613899
131Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.83633445
132Cystic hygroma (HP:0000476)1.82775970
133Abnormality of the ischium (HP:0003174)1.82465224
134Conical tooth (HP:0000698)1.81761092
135Foot dorsiflexor weakness (HP:0009027)1.81517388
136Short palpebral fissure (HP:0012745)1.81356189
137Renal salt wasting (HP:0000127)1.79784430
138Palmoplantar keratoderma (HP:0000982)1.78804761
139Amblyopia (HP:0000646)1.78190385
140Labial hypoplasia (HP:0000066)1.77899201
141Muscular dystrophy (HP:0003560)1.76943187
142Mildly elevated creatine phosphokinase (HP:0008180)1.76367424
143Wrist flexion contracture (HP:0001239)1.74325753
144Fine hair (HP:0002213)1.72327608
145Shoulder girdle muscle weakness (HP:0003547)1.72150743
146Pelvic girdle muscle weakness (HP:0003749)1.70148214
147Thyroiditis (HP:0100646)1.70089259
148Achilles tendon contracture (HP:0001771)1.70018939
149Curly hair (HP:0002212)1.69718439
150Hypertensive crisis (HP:0100735)1.69201431
151Ulnar claw (HP:0001178)1.68060447
152Hypoplastic toenails (HP:0001800)1.67413458
153Spinal rigidity (HP:0003306)1.66836018
154Squamous cell carcinoma (HP:0002860)1.66417279
155Xerostomia (HP:0000217)1.66251303
156Nasolacrimal duct obstruction (HP:0000579)1.66076656
157Ulnar deviation of finger (HP:0009465)1.65443223
158Dry skin (HP:0000958)1.65406787
159Abnormality of chloride homeostasis (HP:0011422)1.64645216
160Melanocytic nevus (HP:0000995)1.64441269
161Abnormality of the gallbladder (HP:0005264)1.64287878
162Hypoplastic female external genitalia (HP:0012815)1.63938065
163Synostosis of carpal bones (HP:0005048)1.63861148
164Abnormality of the nasal mucosa (HP:0000433)1.63603574
165Delusions (HP:0000746)1.62822403
166Hypoplastic heart (HP:0001961)1.61473912
167Abnormality of the Achilles tendon (HP:0005109)1.61318280
168Abnormality of the hip-girdle musculature (HP:0001445)1.60787979
169Abnormality of the musculature of the pelvis (HP:0001469)1.60787979
170Abnormality of the foot musculature (HP:0001436)1.60686820
171Nasal speech (HP:0001611)1.60560860
172Coarse hair (HP:0002208)1.60494900
173Pruritus (HP:0000989)1.60107364
174Abnormality of the dental root (HP:0006486)1.56706874
175Taurodontia (HP:0000679)1.56706874
176Abnormality of permanent molar morphology (HP:0011071)1.56706874
177Ventricular tachycardia (HP:0004756)1.54014527
178Pterygium (HP:0001059)1.51451978
179Skin ulcer (HP:0200042)1.48425040
180Hyperaldosteronism (HP:0000859)1.48076724
181Slow-growing hair (HP:0002217)1.47620413
182Abnormality of hair growth rate (HP:0011363)1.47620413
183Anonychia (HP:0001798)1.47340772
184Abnormality of molar (HP:0011077)1.46079299

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN9.38692936
2PIK3CG3.80847444
3TIE13.57311840
4TRIB33.16575341
5OBSCN3.04337681
6PHKG22.44621455
7PHKG12.44621455
8GRK62.41367048
9MAP2K32.24683496
10EPHA22.20432407
11NEK12.02500938
12PDK41.99735923
13PDK31.99735923
14TGFBR11.90983844
15PKN21.82462114
16FER1.82280004
17LRRK21.71071714
18SIK11.67818880
19RIPK11.59386832
20DMPK1.57751323
21PINK11.57645700
22MAP3K31.56192571
23STK241.54224133
24TGFBR21.42268634
25MAPKAPK31.40692514
26PDK21.39599702
27TRPM71.38722643
28ERBB31.34558423
29PBK1.33318259
30PTK61.24735199
31MST1R1.15683947
32MAP3K21.12392264
33MAP3K91.11199229
34EPHB11.08298054
35EPHB21.06690497
36FGFR21.04552538
37MARK21.02620509
38SMG11.02297135
39KSR20.99384086
40MAP3K70.99056400
41BCKDK0.97776741
42PAK40.94473608
43BLK0.89895247
44PDGFRA0.87914596
45MAP2K40.87386141
46DDR20.85377368
47PRKD10.84909904
48NME20.82283096
49TAOK10.81553710
50PRKD20.78484266
51WNK10.76870440
52MAPKAPK20.76338151
53MAP3K130.72654472
54NME10.72490486
55MAPK120.72053147
56MAP3K120.70707558
57IRAK30.65056655
58MST40.64589613
59PIK3CA0.64425287
60LATS10.63947454
61MET0.63132567
62LIMK10.59988327
63GRK50.59299274
64PRKCH0.58331189
65ILK0.57467573
66RPS6KB20.56516744
67PDPK10.55294820
68CDC42BPA0.54355228
69MAP2K60.54179533
70ERN10.53678404
71STK100.53546168
72DAPK20.52934487
73BMX0.52693416
74FGFR40.50393586
75IKBKB0.49425064
76MAP2K10.48554950
77MAPK110.46867389
78MAP3K110.45566467
79MAP3K10.44511835
80CAMK2A0.43471869
81EEF2K0.42937988
82RET0.42069143
83CSK0.42068368
84PDGFRB0.41790241
85JAK30.41221477
86PAK30.40555985
87KDR0.39682372
88ROCK20.39402487
89FGFR10.39168761
90SIK30.38892113
91MAPK70.38880303
92PTK20.38805128
93PDK10.38746372
94IRAK10.38626121
95CDK90.38427485
96PRKCI0.37381875
97NTRK10.36278004
98TBK10.35490305
99CDK80.35261492
100FGFR30.34464190
101PRKD30.33072710
102ZAP700.32718466
103LATS20.32689723
104PAK60.32580657
105TESK10.32499598
106LMTK20.31478944
107MAP2K20.30886413
108EGFR0.30576892
109FGR0.30261633
110WNK40.29098077
111MYLK0.28991039
112EPHA30.27944541
113PRKCD0.26402207
114FYN0.26290094
115HIPK20.25581624
116SGK10.25504045
117TYRO30.25441588
118CDK60.24952765
119CAMK2G0.24810153
120GSK3A0.24091126
121PRKAA20.23942206
122FRK0.23767079
123IRAK20.23691177
124SRC0.23322318
125CDK70.23286627
126ROCK10.22982200
127KSR10.22388364
128MAP3K60.21625951
129MTOR0.21340064
130MATK0.21004524
131ERBB20.20987398
132NEK60.20555862
133PRKACA0.20326174
134BCR0.19094244
135RPS6KB10.18604065
136AKT20.18017648
137PRKACB0.17401000
138SGK4940.17350606
139SGK2230.17350606
140SCYL20.17217557
141ICK0.13704818
142HCK0.13659979
143AURKB0.12969512
144IKBKE0.11883848
145IGF1R0.11178597
146PIM20.11003199
147CDK120.10115615
148IRAK40.09939168
149ARAF0.08794966
150MAPKAPK50.06958892

Predicted pathways (KEGG)

RankGene SetZ-score
1Salivary secretion_Homo sapiens_hsa049704.07394066
2Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006014.06355779
3Phenylalanine metabolism_Homo sapiens_hsa003604.00166631
4Cyanoamino acid metabolism_Homo sapiens_hsa004603.16304054
5Fat digestion and absorption_Homo sapiens_hsa049753.11945035
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.86415775
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.84273752
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.70644807
9Histidine metabolism_Homo sapiens_hsa003402.48955445
10Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.46347490
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.35468459
12Tyrosine metabolism_Homo sapiens_hsa003502.27513075
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.17012698
14Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.15663257
15Chemical carcinogenesis_Homo sapiens_hsa052042.12152211
16Glycerolipid metabolism_Homo sapiens_hsa005612.11239144
17beta-Alanine metabolism_Homo sapiens_hsa004102.10364296
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.05580740
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.92225317
20Bladder cancer_Homo sapiens_hsa052191.87161906
21Fatty acid degradation_Homo sapiens_hsa000711.82619795
22Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.75317320
23Notch signaling pathway_Homo sapiens_hsa043301.73784393
24Arginine biosynthesis_Homo sapiens_hsa002201.38696183
25Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.37095949
26Carbon metabolism_Homo sapiens_hsa012001.37000997
27Circadian rhythm_Homo sapiens_hsa047101.36952541
28Linoleic acid metabolism_Homo sapiens_hsa005911.35998535
29Dilated cardiomyopathy_Homo sapiens_hsa054141.35591673
30Acute myeloid leukemia_Homo sapiens_hsa052211.34006514
31Propanoate metabolism_Homo sapiens_hsa006401.33361966
32Nitrogen metabolism_Homo sapiens_hsa009101.28979081
33Pentose and glucuronate interconversions_Homo sapiens_hsa000401.28930253
34Renin secretion_Homo sapiens_hsa049241.25197649
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.14662105
36Ether lipid metabolism_Homo sapiens_hsa005651.13327105
37Fatty acid metabolism_Homo sapiens_hsa012121.11933897
38Sphingolipid metabolism_Homo sapiens_hsa006001.10160670
39Endocytosis_Homo sapiens_hsa041441.09373330
40Tight junction_Homo sapiens_hsa045301.09016770
41ECM-receptor interaction_Homo sapiens_hsa045121.07684800
42Glucagon signaling pathway_Homo sapiens_hsa049221.03422202
43Gastric acid secretion_Homo sapiens_hsa049711.02749923
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02277179
45Cardiac muscle contraction_Homo sapiens_hsa042601.00862917
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00728814
47p53 signaling pathway_Homo sapiens_hsa041150.99680803
48Hepatitis C_Homo sapiens_hsa051600.94166785
49Olfactory transduction_Homo sapiens_hsa047400.93515267
50Focal adhesion_Homo sapiens_hsa045100.92773304
51Alzheimers disease_Homo sapiens_hsa050100.91730690
52Inositol phosphate metabolism_Homo sapiens_hsa005620.91698852
53Biosynthesis of amino acids_Homo sapiens_hsa012300.90933011
54Caffeine metabolism_Homo sapiens_hsa002320.90360760
55GnRH signaling pathway_Homo sapiens_hsa049120.89436637
56Fructose and mannose metabolism_Homo sapiens_hsa000510.88715857
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.88421829
58Pyruvate metabolism_Homo sapiens_hsa006200.88156322
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86520284
60Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.86410313
61Phototransduction_Homo sapiens_hsa047440.84112525
62Starch and sucrose metabolism_Homo sapiens_hsa005000.82202750
63Pancreatic secretion_Homo sapiens_hsa049720.82093174
64Sphingolipid signaling pathway_Homo sapiens_hsa040710.81679787
65Adherens junction_Homo sapiens_hsa045200.81067318
66Oxytocin signaling pathway_Homo sapiens_hsa049210.79939222
67Insulin signaling pathway_Homo sapiens_hsa049100.79453655
68Pertussis_Homo sapiens_hsa051330.79021003
69VEGF signaling pathway_Homo sapiens_hsa043700.78606933
70Pancreatic cancer_Homo sapiens_hsa052120.78046069
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77294117
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76331541
73Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.75216905
74Thyroid cancer_Homo sapiens_hsa052160.73102263
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.70971201
76Fatty acid biosynthesis_Homo sapiens_hsa000610.70957334
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.70478200
78Glioma_Homo sapiens_hsa052140.70344052
79Insulin resistance_Homo sapiens_hsa049310.68834659
80Long-term potentiation_Homo sapiens_hsa047200.68520557
81Influenza A_Homo sapiens_hsa051640.68066310
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67609580
83Tryptophan metabolism_Homo sapiens_hsa003800.66246055
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.66200182
85Ras signaling pathway_Homo sapiens_hsa040140.66075995
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.65338915
87Shigellosis_Homo sapiens_hsa051310.64130506
88Amoebiasis_Homo sapiens_hsa051460.62897108
89PPAR signaling pathway_Homo sapiens_hsa033200.62651431
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.62272052
91Melanogenesis_Homo sapiens_hsa049160.62106742
92Glutathione metabolism_Homo sapiens_hsa004800.61708891
93Proteoglycans in cancer_Homo sapiens_hsa052050.61648203
94Circadian entrainment_Homo sapiens_hsa047130.60851180
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59850540
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58909163
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58819223
98Platelet activation_Homo sapiens_hsa046110.58557579
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58505383
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.58353304
101Chronic myeloid leukemia_Homo sapiens_hsa052200.58169751
102Arginine and proline metabolism_Homo sapiens_hsa003300.57638049
103Parkinsons disease_Homo sapiens_hsa050120.55970395
104Choline metabolism in cancer_Homo sapiens_hsa052310.55671159
105Bile secretion_Homo sapiens_hsa049760.54288216
106Calcium signaling pathway_Homo sapiens_hsa040200.53394167
107Renal cell carcinoma_Homo sapiens_hsa052110.52812164
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52281183
109Rap1 signaling pathway_Homo sapiens_hsa040150.49385179
110Estrogen signaling pathway_Homo sapiens_hsa049150.49057785
111Butanoate metabolism_Homo sapiens_hsa006500.48448259
112Salmonella infection_Homo sapiens_hsa051320.47500784
113Sulfur metabolism_Homo sapiens_hsa009200.47499410
114MicroRNAs in cancer_Homo sapiens_hsa052060.46443534
115Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.45970645
116Toll-like receptor signaling pathway_Homo sapiens_hsa046200.45279474
117Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45146498
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44939702
119Fatty acid elongation_Homo sapiens_hsa000620.43599054
120Arachidonic acid metabolism_Homo sapiens_hsa005900.42691973
121AMPK signaling pathway_Homo sapiens_hsa041520.41652477
122Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40311098
123Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40289937
124ErbB signaling pathway_Homo sapiens_hsa040120.39791647
125Sulfur relay system_Homo sapiens_hsa041220.39142496
126RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39004797
127Primary bile acid biosynthesis_Homo sapiens_hsa001200.38190771
128Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38167492
129TNF signaling pathway_Homo sapiens_hsa046680.37922427
130Long-term depression_Homo sapiens_hsa047300.36480859
131Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36062864
132Oxidative phosphorylation_Homo sapiens_hsa001900.35950748
133Viral myocarditis_Homo sapiens_hsa054160.35535578
134HIF-1 signaling pathway_Homo sapiens_hsa040660.34903568
135Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34139581
136Complement and coagulation cascades_Homo sapiens_hsa046100.33963380
137Pentose phosphate pathway_Homo sapiens_hsa000300.33376059
138Galactose metabolism_Homo sapiens_hsa000520.31876116
139Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31802903
140Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31430538
141Axon guidance_Homo sapiens_hsa043600.31201200
142Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28892410
143Tuberculosis_Homo sapiens_hsa051520.27117120
144Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.26850861
145Retinol metabolism_Homo sapiens_hsa008300.26513540
146Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.26117549
147Hippo signaling pathway_Homo sapiens_hsa043900.25307307
148Neurotrophin signaling pathway_Homo sapiens_hsa047220.24832824
149Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.24618763

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