KRT12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: KRT12 encodes the type I intermediate filament chain keratin 12, expressed in corneal epithelia. Mutations in this gene lead to Meesmann corneal dystrophy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1leukotriene metabolic process (GO:0006691)8.60185664
2synaptic vesicle docking involved in exocytosis (GO:0016081)7.95652546
3negative regulation of gene silencing (GO:0060969)7.75478951
4bundle of His cell to Purkinje myocyte communication (GO:0086069)7.58806408
5fatty acid derivative biosynthetic process (GO:1901570)7.30340182
6icosanoid biosynthetic process (GO:0046456)7.30340182
7vitamin A metabolic process (GO:0006776)7.06472210
8glutathione metabolic process (GO:0006749)6.95574401
9mesenchymal cell differentiation involved in kidney development (GO:0072161)6.95517359
10mesenchymal cell differentiation involved in renal system development (GO:2001012)6.95517359
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act6.50045785
12regulation of posttranscriptional gene silencing (GO:0060147)6.43447468
13regulation of gene silencing by miRNA (GO:0060964)6.43447468
14regulation of gene silencing by RNA (GO:0060966)6.43447468
15cysteine metabolic process (GO:0006534)6.42557001
16unsaturated fatty acid biosynthetic process (GO:0006636)6.33917336
17glutamate secretion (GO:0014047)6.27288058
18neurotransmitter-gated ion channel clustering (GO:0072578)6.09450712
19positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.03643433
20presynaptic membrane assembly (GO:0097105)6.02711721
21vocalization behavior (GO:0071625)5.86509884
22regulation of short-term neuronal synaptic plasticity (GO:0048172)5.86346269
23regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.78794008
24cell differentiation involved in metanephros development (GO:0072202)5.78442907
25synaptic vesicle exocytosis (GO:0016079)5.64211934
26regulation of synaptic vesicle exocytosis (GO:2000300)5.60400037
27presynaptic membrane organization (GO:0097090)5.49361438
28regulation of glutamate receptor signaling pathway (GO:1900449)5.47457486
29protein localization to synapse (GO:0035418)5.41193129
30neuronal action potential propagation (GO:0019227)5.12328549
31neuron cell-cell adhesion (GO:0007158)5.11114411
32intermediate filament cytoskeleton organization (GO:0045104)5.09372078
33positive regulation of neurotransmitter secretion (GO:0001956)5.06870755
34peptide catabolic process (GO:0043171)5.02145385
35postsynaptic membrane organization (GO:0001941)4.96184647
36intermediate filament-based process (GO:0045103)4.95583012
37regulation of synaptic vesicle transport (GO:1902803)4.95449482
38synaptic vesicle maturation (GO:0016188)4.85885108
39mechanoreceptor differentiation (GO:0042490)4.79204241
40mitochondrial calcium ion transport (GO:0006851)4.74071248
41desmosome organization (GO:0002934)4.72471330
42locomotory exploration behavior (GO:0035641)4.71535812
43establishment of skin barrier (GO:0061436)4.67784635
44interleukin-6-mediated signaling pathway (GO:0070102)4.61985381
45positive regulation of synapse maturation (GO:0090129)4.55522122
46positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.51530448
47glutathione biosynthetic process (GO:0006750)4.50230908
48cerebellar granule cell differentiation (GO:0021707)4.47767238
49mechanosensory behavior (GO:0007638)4.42974315
50fusion of sperm to egg plasma membrane (GO:0007342)4.42892253
51regulation of water loss via skin (GO:0033561)4.36698960
52fatty acid derivative metabolic process (GO:1901568)4.36418757
53icosanoid metabolic process (GO:0006690)4.36418757
54neuron-neuron synaptic transmission (GO:0007270)4.33716876
55neurotransmitter secretion (GO:0007269)4.33219912
56positive regulation of gastrulation (GO:2000543)4.32908065
57synaptic transmission, glutamatergic (GO:0035249)4.32065958
58metanephric mesenchyme development (GO:0072075)4.30908598
59auditory behavior (GO:0031223)4.27964753
60response to histamine (GO:0034776)4.26242944
61positive regulation of neurotransmitter transport (GO:0051590)4.26187703
62cell proliferation involved in metanephros development (GO:0072203)4.22603229
63pattern specification involved in kidney development (GO:0061004)4.22494109
64regulation of excitatory postsynaptic membrane potential (GO:0060079)4.21663407
65keratinization (GO:0031424)4.15281631
66nonribosomal peptide biosynthetic process (GO:0019184)4.14845951
67protein prenylation (GO:0018342)4.14710738
68prenylation (GO:0097354)4.14710738
69gap junction assembly (GO:0016264)4.11862763
70viral mRNA export from host cell nucleus (GO:0046784)4.10859521
71keratinocyte proliferation (GO:0043616)4.10358018
72long-term synaptic potentiation (GO:0060291)4.08085437
73gamma-aminobutyric acid signaling pathway (GO:0007214)4.07410691
74regulation of postsynaptic membrane potential (GO:0060078)4.07137542
75positive regulation of membrane potential (GO:0045838)4.05863517
76mesonephros development (GO:0001823)4.04103964
77protein targeting to Golgi (GO:0000042)4.03052723
78glutamate receptor signaling pathway (GO:0007215)4.00943471
79regulation of neuronal synaptic plasticity (GO:0048168)3.97435621
80response to pheromone (GO:0019236)3.95858413
81keratinocyte development (GO:0003334)3.95140529
82positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.94516055
83ionotropic glutamate receptor signaling pathway (GO:0035235)3.94119689
84retrograde transport, vesicle recycling within Golgi (GO:0000301)3.91398469
85regulation of synaptic transmission, glutamatergic (GO:0051966)3.90751256
86establishment of protein localization to Golgi (GO:0072600)3.87216049
87regulation of neurotransmitter secretion (GO:0046928)3.85906310
88regulation of long-term neuronal synaptic plasticity (GO:0048169)3.82354312
89positive regulation of epidermal cell differentiation (GO:0045606)3.79793542
90melanin biosynthetic process (GO:0042438)3.78238505
91behavioral response to cocaine (GO:0048148)3.77403346
92negative regulation of synaptic transmission, GABAergic (GO:0032229)3.76710163
93oligosaccharide catabolic process (GO:0009313)3.76427696
94G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.76408977
95regulation of synaptic plasticity (GO:0048167)3.73439816
96negative regulation of keratinocyte proliferation (GO:0010839)3.71705364
97regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.71087222
98urea cycle (GO:0000050)3.70123819
99kidney mesenchyme development (GO:0072074)3.69913329
100regulation of voltage-gated calcium channel activity (GO:1901385)3.65951436
101mitochondrion distribution (GO:0048311)3.65468743
102regulation of synapse maturation (GO:0090128)3.63341904
103hair cell differentiation (GO:0035315)3.60340117
104innervation (GO:0060384)3.57786158
105unsaturated fatty acid metabolic process (GO:0033559)3.55709674
106acrosome reaction (GO:0007340)3.55552771
107membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.53453934
108arginine metabolic process (GO:0006525)3.51539763
109negative regulation of dendrite morphogenesis (GO:0050774)3.47371536
110regulation of neurotransmitter transport (GO:0051588)3.46862901
111multicellular organismal water homeostasis (GO:0050891)3.45002450
112response to auditory stimulus (GO:0010996)3.43741969
113positive regulation of synaptic transmission (GO:0050806)3.43370202
114exploration behavior (GO:0035640)3.42907137
115regulation of dendritic spine morphogenesis (GO:0061001)3.40125375
116regulation of synapse structural plasticity (GO:0051823)3.39673841
117neurotransmitter transport (GO:0006836)3.36073415
118cellular response to electrical stimulus (GO:0071257)3.36020772
119nephron tubule morphogenesis (GO:0072078)3.34124733
120nephron epithelium morphogenesis (GO:0072088)3.34124733
121synaptic vesicle endocytosis (GO:0048488)3.32271885
122urea metabolic process (GO:0019627)3.31559325
123melanin metabolic process (GO:0006582)3.30913080
124regulation of dendritic spine development (GO:0060998)3.30712049
125regulation of glutamate secretion (GO:0014048)3.29615404
126long-term memory (GO:0007616)3.28856170
127cerebellar Purkinje cell differentiation (GO:0021702)3.27819791
128urogenital system development (GO:0001655)3.22126920
129gamma-aminobutyric acid transport (GO:0015812)3.20826567
130membrane depolarization (GO:0051899)3.19305010
131chemosensory behavior (GO:0007635)3.15878006
132acid secretion (GO:0046717)3.14328340
133lipoxygenase pathway (GO:0019372)3.14125391
134regulation of vesicle fusion (GO:0031338)3.13893413
135glycerol metabolic process (GO:0006071)3.13519802
136regulation of neurotransmitter levels (GO:0001505)3.12791773
137fat-soluble vitamin biosynthetic process (GO:0042362)3.10594741
138serotonin metabolic process (GO:0042428)3.09119477
139sperm motility (GO:0030317)3.08638678
140regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.08511435
141phosphorelay signal transduction system (GO:0000160)3.06927887
142negative regulation of dendrite development (GO:2000171)3.06001220
143skeletal muscle tissue regeneration (GO:0043403)3.05857233
144fatty acid biosynthetic process (GO:0006633)3.04259624
145negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.04100590
146peptide metabolic process (GO:0006518)3.03968965
147negative regulation of hormone biosynthetic process (GO:0032353)3.02853448
148negative regulation of hormone metabolic process (GO:0032351)3.02853448
149proline transport (GO:0015824)3.01962344
150galactose catabolic process (GO:0019388)3.01863956
151membrane assembly (GO:0071709)3.01592300
152activation of protein kinase A activity (GO:0034199)3.01438318
153secondary metabolite biosynthetic process (GO:0044550)3.01138108
154regulation of synaptic transmission (GO:0050804)3.00909893
155calcium ion-dependent exocytosis (GO:0017156)3.00513819
156microtubule depolymerization (GO:0007019)2.99617313
157G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.99025905
158membrane hyperpolarization (GO:0060081)2.97817566
159cell proliferation involved in kidney development (GO:0072111)2.97541535
160G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.97461034
161protein localization to Golgi apparatus (GO:0034067)2.96799947
162single strand break repair (GO:0000012)2.95703748
163diterpenoid biosynthetic process (GO:0016102)2.94878671
164plasma membrane fusion (GO:0045026)2.94652692
165negative regulation of amino acid transport (GO:0051956)2.93583665
166fear response (GO:0042596)2.93458555
167positive regulation of epidermis development (GO:0045684)2.93363771
168positive regulation of synapse assembly (GO:0051965)2.92071812
169behavioral fear response (GO:0001662)2.91329623
170behavioral defense response (GO:0002209)2.91329623
171drug transmembrane transport (GO:0006855)2.91192074
172synaptic transmission (GO:0007268)2.90386702
173transferrin transport (GO:0033572)2.89660812
174long term synaptic depression (GO:0060292)2.89235638
175vesicle docking involved in exocytosis (GO:0006904)2.88859328
176layer formation in cerebral cortex (GO:0021819)2.87820656
177positive regulation of DNA-templated transcription, elongation (GO:0032786)2.87559446
178poly(A)+ mRNA export from nucleus (GO:0016973)2.87032798
179protein-chromophore linkage (GO:0018298)2.86085836
180nitrogen cycle metabolic process (GO:0071941)2.85814845
181regulation of oxidative phosphorylation (GO:0002082)2.85063485
182alditol metabolic process (GO:0019400)2.83852210
183positive regulation of cardiac muscle cell differentiation (GO:2000727)2.83549506
184negative regulation of kidney development (GO:0090185)2.82662107
185protein ADP-ribosylation (GO:0006471)2.78953705
186one-carbon compound transport (GO:0019755)2.78915320
187ventricular system development (GO:0021591)2.77383467
188regulation of gene silencing (GO:0060968)2.77157746
189GDP-mannose metabolic process (GO:0019673)2.75323777
190embryonic skeletal joint morphogenesis (GO:0060272)2.74724129
191water homeostasis (GO:0030104)2.72971700
192regulation of guanylate cyclase activity (GO:0031282)2.72704992
193long-chain fatty acid biosynthetic process (GO:0042759)2.69774589
194positive regulation of keratinocyte differentiation (GO:0045618)2.68723720
195cilium movement (GO:0003341)2.66693706
196glutathione derivative biosynthetic process (GO:1901687)2.62646907
197glutathione derivative metabolic process (GO:1901685)2.62646907
198peptide biosynthetic process (GO:0043043)2.62067678
199regulation of transcription involved in cell fate commitment (GO:0060850)2.62005686
200leukotriene biosynthetic process (GO:0019370)12.2701625

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.31873879
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat7.18139122
3TP63_17297297_ChIP-ChIP_HaCaT_Human5.77960185
4EZH2_22144423_ChIP-Seq_EOC_Human4.72523376
5GBX2_23144817_ChIP-Seq_PC3_Human4.53701726
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.38945732
7P63_26484246_Chip-Seq_KERATINOCYTES_Human3.00514030
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.00113685
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.94830762
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.77788792
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.77514631
12TAF15_26573619_Chip-Seq_HEK293_Human2.70642970
13GATA1_19941826_ChIP-Seq_K562_Human2.57731513
14GATA2_19941826_ChIP-Seq_K562_Human2.52684624
15RARB_27405468_Chip-Seq_BRAIN_Mouse2.51041113
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.46987373
17REST_21632747_ChIP-Seq_MESCs_Mouse2.46000390
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.44369309
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.44369309
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.33863516
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.29117095
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.27754023
23TCF4_18268006_ChIP-ChIP_LS174T_Human2.27720466
24MTF2_20144788_ChIP-Seq_MESCs_Mouse2.25631652
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.25604477
26JARID2_20075857_ChIP-Seq_MESCs_Mouse2.25468249
27SMAD_19615063_ChIP-ChIP_OVARY_Human2.24741187
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.24493378
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.22599158
30GATA6_25053715_ChIP-Seq_YYC3_Human2.16991749
31EED_16625203_ChIP-ChIP_MESCs_Mouse2.14486302
32REST_18959480_ChIP-ChIP_MESCs_Mouse2.08346592
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.04527700
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.04482851
35CTBP1_25329375_ChIP-Seq_LNCAP_Human2.03826672
36RNF2_27304074_Chip-Seq_ESCs_Mouse2.00090524
37DROSHA_22980978_ChIP-Seq_HELA_Human1.99034919
38EGR1_19032775_ChIP-ChIP_M12_Human1.97148492
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.96528041
40GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.90983126
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.89364393
42SMAD4_21799915_ChIP-Seq_A2780_Human1.88845911
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86317347
44EZH2_27294783_Chip-Seq_ESCs_Mouse1.83271730
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80039578
46RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78805143
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76745147
48CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.76284067
49P300_19829295_ChIP-Seq_ESCs_Human1.76257698
50AR_21572438_ChIP-Seq_LNCaP_Human1.69703197
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67567830
52PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.63682766
53EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.60069128
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.57689139
55MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.57169579
56IKZF1_21737484_ChIP-ChIP_HCT116_Human1.56355159
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.56094054
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.55728535
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.54866889
60FUS_26573619_Chip-Seq_HEK293_Human1.53715155
61NCOR1_26117541_ChIP-Seq_K562_Human1.53362400
62HIF1A_21447827_ChIP-Seq_MCF-7_Human1.52677962
63ZNF263_19887448_ChIP-Seq_K562_Human1.52414231
64AR_25329375_ChIP-Seq_VCAP_Human1.49748316
65GATA4_25053715_ChIP-Seq_YYC3_Human1.48959755
66TP63_23658742_ChIP-Seq_EP156T_Human1.48845941
67P53_21459846_ChIP-Seq_SAOS-2_Human1.46876650
68KLF5_25053715_ChIP-Seq_YYC3_Human1.44813965
69SOX2_21211035_ChIP-Seq_LN229_Gbm1.43475525
70EGR1_23403033_ChIP-Seq_LIVER_Mouse1.43470875
71TP63_22573176_ChIP-Seq_HFKS_Human1.43268423
72SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.43075565
73STAT3_23295773_ChIP-Seq_U87_Human1.40259577
74VDR_22108803_ChIP-Seq_LS180_Human1.40096143
75P53_22127205_ChIP-Seq_FIBROBLAST_Human1.38588240
76CBP_20019798_ChIP-Seq_JUKART_Human1.37969315
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37969315
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37023844
79RBPJ_21746931_ChIP-Seq_IB4_Human1.36789006
80OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35193382
81ESR1_20079471_ChIP-ChIP_T-47D_Human1.33868769
82SOX2_27498859_Chip-Seq_STOMACH_Mouse1.33294270
83TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.33006700
84CBX2_27304074_Chip-Seq_ESCs_Mouse1.32986230
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32680819
86AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32023985
87BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32006876
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31331166
89ERG_21242973_ChIP-ChIP_JURKAT_Human1.31152746
90SOX9_24532713_ChIP-Seq_HFSC_Mouse1.30673096
91MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.30332959
92SOX2_20726797_ChIP-Seq_SW620_Human1.30045737
93GATA3_24758297_ChIP-Seq_MCF-7_Human1.29549687
94HOXB7_26014856_ChIP-Seq_BT474_Human1.28667220
95ETV1_20927104_ChIP-Seq_GIST48_Human1.28282332
96ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27922535
97PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.26812039
98TCF4_23295773_ChIP-Seq_U87_Human1.26607023
99RARG_19884340_ChIP-ChIP_MEFs_Mouse1.26329230
100RNF2_27304074_Chip-Seq_NSC_Mouse1.25931571
101PHF8_20622853_ChIP-Seq_HELA_Human1.25449640
102PPAR_26484153_Chip-Seq_NCI-H1993_Human1.25188127
103NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25057686
104GATA6_21074721_ChIP-Seq_CACO-2_Human1.24773619
105YY1_22570637_ChIP-Seq_MALME-3M_Human1.24542400
106ARNT_22903824_ChIP-Seq_MCF-7_Human1.24405132
107CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.24087473
108FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.24080615
109GATA3_26560356_Chip-Seq_TH1_Human1.23337093
110CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.21882618
111EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21649033
112PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.21458306
113AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.21453589
114FOXH1_21741376_ChIP-Seq_EPCs_Human1.21280413
115GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.20948925
116CEBPB_22108803_ChIP-Seq_LS180_Human1.19836486
117AHR_22903824_ChIP-Seq_MCF-7_Human1.19494146
118EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.18619882
119FOXM1_26456572_ChIP-Seq_MCF-7_Human1.18553992
120HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.17598861
121PRDM14_20953172_ChIP-Seq_ESCs_Human1.17029405
122UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16330493
123MYC_19829295_ChIP-Seq_ESCs_Human1.14578573
124ERG_20517297_ChIP-Seq_VCAP_Human1.14327181
125RXR_22108803_ChIP-Seq_LS180_Human1.14171532
126TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14135672
127RBPJ_22232070_ChIP-Seq_NCS_Mouse1.13792232
128HNFA_21074721_ChIP-Seq_CACO-2_Human1.13703152
129CBX2_22325352_ChIP-Seq_293T-Rex_Human1.13409194
130NANOG_18555785_Chip-Seq_ESCs_Mouse1.13379945
131ELF5_23300383_ChIP-Seq_T47D_Human1.13345079
132AR_19668381_ChIP-Seq_PC3_Human1.13172253
133ELF1_17652178_ChIP-ChIP_JURKAT_Human1.12851118
134TP53_16413492_ChIP-PET_HCT116_Human1.12218489
135RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12075625
136* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10813020
137RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09930903
138PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09391603
139FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08453184
140FOXA1_25329375_ChIP-Seq_VCAP_Human1.08453184
141PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.08267983
142MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08264285
143CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06265796
144AR_20517297_ChIP-Seq_VCAP_Human1.06000704
145SOX2_19829295_ChIP-Seq_ESCs_Human1.03529411
146NANOG_19829295_ChIP-Seq_ESCs_Human1.03529411
147ATF3_27146783_Chip-Seq_COLON_Human1.03445253
148WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03410704
149TP53_18474530_ChIP-ChIP_U2OS_Human1.03058386
150IGF1R_20145208_ChIP-Seq_DFB_Human1.01933108
151TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01418725
152POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01418725
153FLI1_27457419_Chip-Seq_LIVER_Mouse1.00633825
154DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00622951
155SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00437530
156SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00437530
157YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00311870
158RING1B_27294783_Chip-Seq_ESCs_Mouse0.99598700
159* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99405533
160ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99288339
161MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99282955
162CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99242789
163SOX9_26525672_Chip-Seq_HEART_Mouse0.99000372
164RUNX2_22187159_ChIP-Seq_PCA_Human0.98634342
165JUN_21703547_ChIP-Seq_K562_Human0.98549665
166ER_23166858_ChIP-Seq_MCF-7_Human0.98473533
167KDM2B_26808549_Chip-Seq_REH_Human0.98142105
168CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97584328
169* CDX2_22108803_ChIP-Seq_LS180_Human0.97276830
170CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.96683855
171ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96647556
172SMAD3_21741376_ChIP-Seq_ESCs_Human0.96106691
173E2F1_18555785_Chip-Seq_ESCs_Mouse0.95367693
174P53_22387025_ChIP-Seq_ESCs_Mouse0.95288432
175E2F1_20622854_ChIP-Seq_HELA_Human0.95239878
176GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94555604
177NFYB_21822215_ChIP-Seq_K562_Human0.92292045
178NCOR_22424771_ChIP-Seq_293T_Human0.91887712
179GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91867789
180OCT4_20526341_ChIP-Seq_ESCs_Human0.91696010
181ERA_21632823_ChIP-Seq_H3396_Human0.89130931
182GATA3_21878914_ChIP-Seq_MCF-7_Human0.88353683
183RAC3_21632823_ChIP-Seq_H3396_Human0.87051216
184SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86504852
185STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.85482205
186SPI1_23127762_ChIP-Seq_K562_Human0.84933522
187ETV2_25802403_ChIP-Seq_MESCs_Mouse0.83470346
188FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.82664240
189CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82480291

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.01190865
2MP0003880_abnormal_central_pattern5.85275400
3MP0003011_delayed_dark_adaptation4.27717854
4MP0003635_abnormal_synaptic_transmissio3.95370594
5MP0004264_abnormal_extraembryonic_tissu3.62427423
6MP0002796_impaired_skin_barrier3.60411328
7MP0004270_analgesia3.51312573
8MP0009745_abnormal_behavioral_response3.45587609
9MP0005501_abnormal_skin_physiology3.36258581
10MP0002063_abnormal_learning/memory/cond3.24524431
11MP0001968_abnormal_touch/_nociception3.21131553
12MP0005275_abnormal_skin_tensile3.13152133
13MP0002064_seizures3.10660925
14MP0009046_muscle_twitch3.03675545
15MP0005410_abnormal_fertilization2.80424121
16MP0002572_abnormal_emotion/affect_behav2.78657260
17MP0009780_abnormal_chondrocyte_physiolo2.60837909
18MP0002736_abnormal_nociception_after2.56026880
19MP0002822_catalepsy2.54157430
20MP0002098_abnormal_vibrissa_morphology2.49721244
21MP0005646_abnormal_pituitary_gland2.43173098
22MP0002272_abnormal_nervous_system2.42049680
23MP0000579_abnormal_nail_morphology2.40459306
24MP0002734_abnormal_mechanical_nocicepti2.37745308
25MP0003879_abnormal_hair_cell2.33642034
26MP0001486_abnormal_startle_reflex2.28451660
27MP0008995_early_reproductive_senescence2.27526313
28MP0003878_abnormal_ear_physiology2.23177082
29MP0005377_hearing/vestibular/ear_phenot2.23177082
30MP0002234_abnormal_pharynx_morphology2.19312073
31MP0005171_absent_coat_pigmentation2.06290365
32MP0005360_urolithiasis2.05975545
33MP0001501_abnormal_sleep_pattern2.05589961
34MP0002089_abnormal_postnatal_growth/wei2.03412649
35MP0003453_abnormal_keratinocyte_physiol2.00684830
36MP0001764_abnormal_homeostasis2.00086768
37MP0010678_abnormal_skin_adnexa1.99192150
38MP0003787_abnormal_imprinting1.98229735
39MP0002067_abnormal_sensory_capabilities1.94353947
40MP0003693_abnormal_embryo_hatching1.83418543
41MP0002735_abnormal_chemical_nociception1.78282349
42MP0002009_preneoplasia1.73847930
43MP0001440_abnormal_grooming_behavior1.73111023
44MP0005551_abnormal_eye_electrophysiolog1.70387001
45MP0001216_abnormal_epidermal_layer1.70138395
46MP0004924_abnormal_behavior1.68791122
47MP0005386_behavior/neurological_phenoty1.68791122
48MP0002163_abnormal_gland_morphology1.68697668
49MP0009379_abnormal_foot_pigmentation1.63672569
50MP0008569_lethality_at_weaning1.61947212
51MP0002557_abnormal_social/conspecific_i1.57427317
52MP0008789_abnormal_olfactory_epithelium1.56645776
53MP0001970_abnormal_pain_threshold1.56094315
54MP0004185_abnormal_adipocyte_glucose1.52525892
55MP0005423_abnormal_somatic_nervous1.50042229
56MP0002733_abnormal_thermal_nociception1.48834341
57MP0003329_amyloid_beta_deposits1.47774854
58MP0010771_integument_phenotype1.47304112
59MP0009697_abnormal_copulation1.44998994
60MP0001502_abnormal_circadian_rhythm1.42513564
61MP0004147_increased_porphyrin_level1.42107770
62MP0001984_abnormal_olfaction1.38555154
63MP0000427_abnormal_hair_cycle1.37677825
64MP0001188_hyperpigmentation1.35420016
65MP0002653_abnormal_ependyma_morphology1.35278176
66MP0004811_abnormal_neuron_physiology1.34979547
67MP0005257_abnormal_intraocular_pressure1.34667823
68MP0000372_irregular_coat_pigmentation1.33953056
69MP0003633_abnormal_nervous_system1.31661345
70MP0003718_maternal_effect1.31593505
71MP0003656_abnormal_erythrocyte_physiolo1.31156779
72MP0005666_abnormal_adipose_tissue1.29649251
73MP0003136_yellow_coat_color1.27635811
74MP0002095_abnormal_skin_pigmentation1.26475244
75MP0005332_abnormal_amino_acid1.26112436
76MP0000778_abnormal_nervous_system1.25081159
77MP0002876_abnormal_thyroid_physiology1.24146807
78MP0001529_abnormal_vocalization1.23981788
79MP0000647_abnormal_sebaceous_gland1.23662754
80MP0001905_abnormal_dopamine_level1.23352290
81MP0002184_abnormal_innervation1.22887695
82MP0004885_abnormal_endolymph1.20786817
83MP0000377_abnormal_hair_follicle1.20537357
84MP0003950_abnormal_plasma_membrane1.20531981
85MP0005379_endocrine/exocrine_gland_phen1.20463521
86MP0002066_abnormal_motor_capabilities/c1.20146607
87MP0002882_abnormal_neuron_morphology1.18932848
88MP0005253_abnormal_eye_physiology1.17068742
89MP0008260_abnormal_autophagy1.15933723
90MP0000613_abnormal_salivary_gland1.14537152
91MP0002909_abnormal_adrenal_gland1.14030183
92MP0008877_abnormal_DNA_methylation1.12689403
93MP0002090_abnormal_vision1.11539613
94MP0005409_darkened_coat_color1.10868190
95MP0000678_abnormal_parathyroid_gland1.10195889
96MP0003631_nervous_system_phenotype1.09409079
97MP0004145_abnormal_muscle_electrophysio1.07055029
98MP0004084_abnormal_cardiac_muscle1.06611166
99MP0000371_diluted_coat_color1.04050296
100MP0003646_muscle_fatigue1.03268338
101MP0000955_abnormal_spinal_cord1.03198307
102MP0008872_abnormal_physiological_respon1.03195412
103MP0001765_abnormal_ion_homeostasis1.01609273
104MP0002837_dystrophic_cardiac_calcinosis1.01513574
105MP0005083_abnormal_biliary_tract0.99510091
106MP0009053_abnormal_anal_canal0.97824745
107MP0010386_abnormal_urinary_bladder0.96844377
108MP0010329_abnormal_lipoprotein_level0.96732631
109MP0002277_abnormal_respiratory_mucosa0.96178610
110MP0009115_abnormal_fat_cell0.94524214
111MP0008874_decreased_physiological_sensi0.93844281
112MP0004043_abnormal_pH_regulation0.93789421
113MP0000751_myopathy0.93782130
114MP0001929_abnormal_gametogenesis0.92890646
115MP0005375_adipose_tissue_phenotype0.91291051
116MP0000015_abnormal_ear_pigmentation0.90876184
117MP0001963_abnormal_hearing_physiology0.89229073
118MP0002229_neurodegeneration0.89027916
119MP0001666_abnormal_nutrient_absorption0.88922620
120MP0002139_abnormal_hepatobiliary_system0.87930145
121MP0000367_abnormal_coat/_hair0.87869251
122MP0004957_abnormal_blastocyst_morpholog0.86743079
123MP0006276_abnormal_autonomic_nervous0.85672066
124MP0004858_abnormal_nervous_system0.84314828
125MP0002152_abnormal_brain_morphology0.83631239
126MP0000490_abnormal_crypts_of0.82306096
127MP0000013_abnormal_adipose_tissue0.82110361
128MP0005636_abnormal_mineral_homeostasis0.82021828
129MP0000569_abnormal_digit_pigmentation0.80926140
130MP0001324_abnormal_eye_pigmentation0.80731061
131MP0000566_synostosis0.78789295
132MP0002102_abnormal_ear_morphology0.78700261
133MP0004019_abnormal_vitamin_homeostasis0.78688707
134MP0003698_abnormal_male_reproductive0.78111246
135MP0001485_abnormal_pinna_reflex0.77742597
136MP0002233_abnormal_nose_morphology0.77497429
137MP0000631_abnormal_neuroendocrine_gland0.76867616
138MP0004484_altered_response_of0.76587235
139MP0001177_atelectasis0.75897758
140MP0002210_abnormal_sex_determination0.73856899
141MP0001756_abnormal_urination0.71661771
142MP0005451_abnormal_body_composition0.70588349
143MP0004742_abnormal_vestibular_system0.70430868
144MP0003183_abnormal_peptide_metabolism0.69228240
145MP0003315_abnormal_perineum_morphology0.68867978
146MP0003122_maternal_imprinting0.68859168
147MP0004085_abnormal_heartbeat0.68210398
148MP0001873_stomach_inflammation0.67853173
149MP0002069_abnormal_eating/drinking_beha0.67069549
150MP0004142_abnormal_muscle_tone0.66214175
151MP0001663_abnormal_digestive_system0.66018478
152MP0005499_abnormal_olfactory_system0.65998779
153MP0005394_taste/olfaction_phenotype0.65998779
154MP0002752_abnormal_somatic_nervous0.65684856
155MP0003786_premature_aging0.65231365
156MP0010234_abnormal_vibrissa_follicle0.64335310
157MP0003123_paternal_imprinting0.64286409
158MP0001119_abnormal_female_reproductive0.64260177
159MP0004215_abnormal_myocardial_fiber0.64208023
160MP0005085_abnormal_gallbladder_physiolo0.63682304
161MP0000609_abnormal_liver_physiology0.62877016
162MP0002075_abnormal_coat/hair_pigmentati0.61966057
163MP0000653_abnormal_sex_gland0.61753287
164MP0000383_abnormal_hair_follicle0.61700110
165MP0008004_abnormal_stomach_pH0.61265161
166MP0003638_abnormal_response/metabolism_0.60690997
167MP0005376_homeostasis/metabolism_phenot0.60232719
168MP0003632_abnormal_nervous_system0.60139822
169MP0001664_abnormal_digestion0.60048412
170MP0002060_abnormal_skin_morphology0.58137698
171MP0003075_altered_response_to0.58051470
172MP0005670_abnormal_white_adipose0.56849352
173MP0002970_abnormal_white_adipose0.55978582
174MP0002118_abnormal_lipid_homeostasis0.55825403
175MP0009931_abnormal_skin_appearance0.55764574
176MP0003938_abnormal_ear_development0.54890320
177MP0005535_abnormal_body_temperature0.54428005
178MP0005408_hypopigmentation0.53773228
179MP0001186_pigmentation_phenotype0.53736620
180MP0004233_abnormal_muscle_weight0.51311271

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)9.61199057
2Epileptic encephalopathy (HP:0200134)7.16692855
3Decreased electroretinogram (ERG) amplitude (HP:0000654)6.55424248
4Atonic seizures (HP:0010819)6.40109447
5Hyperventilation (HP:0002883)6.32907251
6Focal seizures (HP:0007359)5.88055764
7Alopecia of scalp (HP:0002293)5.47515630
8Myokymia (HP:0002411)5.38149943
9Febrile seizures (HP:0002373)5.30622712
10Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.20177094
11Erythroderma (HP:0001019)5.19473306
12Abnormality of placental membranes (HP:0011409)5.10413144
13Amniotic constriction ring (HP:0009775)5.10413144
14Fragile nails (HP:0001808)4.81629379
15Abnormality of nail color (HP:0100643)4.77682929
16Broad-based gait (HP:0002136)4.74976254
17Absence seizures (HP:0002121)4.63431254
18Oral leukoplakia (HP:0002745)4.55914371
19Dialeptic seizures (HP:0011146)4.30749450
20Congenital ichthyosiform erythroderma (HP:0007431)4.27694294
21* Corneal dystrophy (HP:0001131)4.26803040
22Visual hallucinations (HP:0002367)4.17271497
23Abnormality of the fovea (HP:0000493)3.93810178
24Hypopigmentation of the fundus (HP:0007894)3.93283790
25Blue irides (HP:0000635)3.90119114
26Poor eye contact (HP:0000817)3.88008321
27Generalized tonic-clonic seizures (HP:0002069)3.84919207
28Abnormality of small intestinal villus morphology (HP:0011472)3.78537482
29Villous atrophy (HP:0011473)3.78537482
30Woolly hair (HP:0002224)3.74510423
31Gaze-evoked nystagmus (HP:0000640)3.74023603
32Diastasis recti (HP:0001540)3.67943652
33Increased IgE level (HP:0003212)3.58267461
34Recurrent corneal erosions (HP:0000495)3.53588585
35Attenuation of retinal blood vessels (HP:0007843)3.53461477
36Abnormality of glycolipid metabolism (HP:0010969)3.52143745
37Abnormality of liposaccharide metabolism (HP:0010968)3.52143745
38Abnormality of glycosphingolipid metabolism (HP:0004343)3.52143745
39Decreased central vision (HP:0007663)3.41756598
40Stereotypic behavior (HP:0000733)3.31133382
41Dynein arm defect of respiratory motile cilia (HP:0012255)3.26289893
42Absent/shortened dynein arms (HP:0200106)3.26289893
43Dysmetric saccades (HP:0000641)3.25930600
44Protruding tongue (HP:0010808)3.25321269
45Abnormal social behavior (HP:0012433)3.24390102
46Impaired social interactions (HP:0000735)3.24390102
47Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.22200631
48Amblyopia (HP:0000646)3.19668362
49Abnormal ciliary motility (HP:0012262)3.18356804
50Nasal polyposis (HP:0100582)3.11917113
51Palmoplantar hyperkeratosis (HP:0000972)3.10362296
52Protuberant abdomen (HP:0001538)3.09307740
53Broad alveolar ridges (HP:0000187)3.09064726
54Squamous cell carcinoma (HP:0002860)3.04040903
55Progressive cerebellar ataxia (HP:0002073)3.03371485
56Impaired vibration sensation in the lower limbs (HP:0002166)3.00888730
57Drooling (HP:0002307)2.98533321
58Excessive salivation (HP:0003781)2.98533321
59Plantar hyperkeratosis (HP:0007556)2.96539475
60Flat acetabular roof (HP:0003180)2.95515597
61Urinary bladder sphincter dysfunction (HP:0002839)2.92137951
62Palmar hyperkeratosis (HP:0010765)2.88747243
63Dysdiadochokinesis (HP:0002075)2.85642225
64Epileptiform EEG discharges (HP:0011182)2.83419358
65Aplasia/Hypoplasia of the fovea (HP:0008060)2.73625415
66Hypoplasia of the fovea (HP:0007750)2.73625415
67Choroideremia (HP:0001139)2.71574995
68Generalized hypopigmentation of hair (HP:0011358)2.69504697
69Inability to walk (HP:0002540)2.68873459
70Hyperactive renin-angiotensin system (HP:0000841)2.68412089
71Abnormal eating behavior (HP:0100738)2.67198496
72Abnormal respiratory motile cilium physiology (HP:0012261)2.66995404
73Ileus (HP:0002595)2.58598411
74Corneal erosion (HP:0200020)2.57688287
75Iris hypopigmentation (HP:0007730)2.57196087
76Abnormality of dental color (HP:0011073)2.53960646
77Impaired smooth pursuit (HP:0007772)2.51355521
78Sparse scalp hair (HP:0002209)2.45579728
79Termporal pattern (HP:0011008)2.45537993
80Insidious onset (HP:0003587)2.45537993
81Fetal akinesia sequence (HP:0001989)2.45059695
82Dysmetria (HP:0001310)2.44661197
83Brittle hair (HP:0002299)2.44239363
84Absent speech (HP:0001344)2.43597271
85Sparse eyelashes (HP:0000653)2.42932361
86EEG with generalized epileptiform discharges (HP:0011198)2.42814049
87Impaired vibratory sensation (HP:0002495)2.41228013
88Chronic bronchitis (HP:0004469)2.37613826
89Truncal ataxia (HP:0002078)2.36646490
90Action tremor (HP:0002345)2.36235141
91Vertebral arch anomaly (HP:0008438)2.34265337
92Abnormality of the lower motor neuron (HP:0002366)2.33989655
93Chronic hepatic failure (HP:0100626)2.33913075
94Hyperthyroidism (HP:0000836)2.31543165
95Abnormal respiratory epithelium morphology (HP:0012253)2.31310712
96Abnormal respiratory motile cilium morphology (HP:0005938)2.31310712
97Autoamputation (HP:0001218)2.30743582
98Abnormality of the nasal mucosa (HP:0000433)2.27263976
99Premature ovarian failure (HP:0008209)2.27212103
100Ankle clonus (HP:0011448)2.26680997
101Status epilepticus (HP:0002133)2.26400383
102Depression (HP:0000716)2.26112853
103Furrowed tongue (HP:0000221)2.21814343
104Onycholysis (HP:0001806)2.21239287
105Hypsarrhythmia (HP:0002521)2.19967785
106Abnormality of the labia minora (HP:0012880)2.19898576
107Ocular albinism (HP:0001107)2.19342253
108Torticollis (HP:0000473)2.17340883
109Abnormal hair whorl (HP:0010721)2.17051457
110Thickened helices (HP:0000391)2.16132881
111Pustule (HP:0200039)2.15445379
112Acanthosis nigricans (HP:0000956)2.15267625
113Annular pancreas (HP:0001734)2.14853255
114Anxiety (HP:0000739)2.14222510
115Male infertility (HP:0003251)2.14181019
116Severe visual impairment (HP:0001141)2.14106704
117Entropion (HP:0000621)2.13205407
118Sensory axonal neuropathy (HP:0003390)2.12952518
119Scanning speech (HP:0002168)2.10929020
120Abnormality of DNA repair (HP:0003254)2.06397457
121Constricted visual fields (HP:0001133)2.04502029
122Polycythemia (HP:0001901)2.04472439
123Postural instability (HP:0002172)2.03873008
124Redundant skin (HP:0001582)2.03263970
125Spastic gait (HP:0002064)2.03059726
126Resting tremor (HP:0002322)2.02255740
127Abnormality of ocular smooth pursuit (HP:0000617)2.00971349
128Bronchitis (HP:0012387)2.00620358
129* Nonprogressive disorder (HP:0003680)10.6570168
130Unilateral renal agenesis (HP:0000122)1.99235614
131Gait imbalance (HP:0002141)1.99224349
132Poikiloderma (HP:0001029)1.99120650
133Aplasia/Hypoplasia of the earlobes (HP:0009906)1.98801081
134Incomplete penetrance (HP:0003829)1.97743753
135Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.97671929
136Degeneration of the lateral corticospinal tracts (HP:0002314)1.97671929
137Widely spaced teeth (HP:0000687)1.97604925
138Urinary urgency (HP:0000012)1.96998309
139Tongue fasciculations (HP:0001308)1.96298606
140Rhinitis (HP:0012384)1.95144930
141Generalized myoclonic seizures (HP:0002123)1.94797235
142Hypoplastic scapulae (HP:0000882)1.94644924
143Aplasia/Hypoplasia of the scapulae (HP:0006713)1.94644924
144Polyphagia (HP:0002591)1.94116396
145Carpal bone hypoplasia (HP:0001498)1.93506779
146Abnormality of salivation (HP:0100755)1.92453687
147Short chin (HP:0000331)1.92206262
148Right ventricular cardiomyopathy (HP:0011663)1.91897666
149Abnormal gallbladder physiology (HP:0012438)1.91737238
150Cholecystitis (HP:0001082)1.91737238
151Aplasia/Hypoplasia of the macula (HP:0008059)1.90346031
152Abnormality of the corticospinal tract (HP:0002492)1.89503595
153Genetic anticipation (HP:0003743)1.89400205
154Increased corneal curvature (HP:0100692)1.88573490
155Keratoconus (HP:0000563)1.88573490
156Focal dystonia (HP:0004373)1.88560627
157Lower limb muscle weakness (HP:0007340)1.88053981
158Poikilocytosis (HP:0004447)1.87495347
159Fair hair (HP:0002286)1.86614685
160Hemiparesis (HP:0001269)1.84619612
161Lower limb amyotrophy (HP:0007210)1.84418547
162Pheochromocytoma (HP:0002666)1.83890286
163Abnormality of the thoracic spine (HP:0100711)1.83577580
164Bradykinesia (HP:0002067)1.82869977
165Abnormality of the periventricular white matter (HP:0002518)1.82773018
166Keratoconjunctivitis sicca (HP:0001097)1.82162128
167Congenital primary aphakia (HP:0007707)1.81925869
168Pili torti (HP:0003777)1.81911765
169Aplasia/Hypoplasia affecting the retina (HP:0008061)1.80951139
170Papilledema (HP:0001085)1.79470196
171Amelogenesis imperfecta (HP:0000705)1.79231173
172Keratoconjunctivitis (HP:0001096)1.79178667
173Abnormality of the lumbar spine (HP:0100712)1.77607609
174Nephrogenic diabetes insipidus (HP:0009806)1.77602558
175Flared iliac wings (HP:0002869)1.77409769
176Gait ataxia (HP:0002066)1.76557003
177Recurrent bronchitis (HP:0002837)1.75187348
178Renal Fanconi syndrome (HP:0001994)1.74643514
179Short ribs (HP:0000773)1.74384338
180Medial flaring of the eyebrow (HP:0010747)1.73861224
181Hypophosphatemic rickets (HP:0004912)1.73519181
182Keratitis (HP:0000491)1.72566835
183Abdominal distention (HP:0003270)1.70295436
184* Opacification of the corneal stroma (HP:0007759)1.69088654
185Neonatal death (HP:0003811)1.68385043
186Petechiae (HP:0000967)1.67970640
187Acanthocytosis (HP:0001927)1.67735869
188Abnormal hemoglobin (HP:0011902)1.67330656
189Fine hair (HP:0002213)1.66437335
190Abnormality of the alveolar ridges (HP:0006477)1.65404570
191Popliteal pterygium (HP:0009756)1.62612124
192Hoarse voice (HP:0001609)1.62207169
193Recurrent bacterial skin infections (HP:0005406)1.62191349
194Hypotrichosis (HP:0001006)1.61697026
195Hyponatremia (HP:0002902)1.60226883
196Paralysis (HP:0003470)1.59834177
197Seborrheic dermatitis (HP:0001051)1.58369077
198Tinnitus (HP:0000360)1.57918476

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK6.56041519
2EPHA45.17933958
3MST44.63212522
4WNK14.50940968
5TLK14.34308968
6DAPK24.24142556
7BRSK24.05113212
8CCNB13.39058278
9CDK193.14987494
10BRD43.12952573
11MST1R3.08098333
12NTRK33.04997996
13MAP3K92.94968342
14MAP3K42.64030382
15DAPK12.62310529
16MAP2K72.57651741
17PLK22.27721089
18MARK32.18318609
19AKT32.13213188
20MAP3K121.95831543
21GRK61.92740329
22STK161.72569325
23TGFBR21.72161863
24KSR21.72005788
25OXSR11.71188542
26GRK71.68333289
27MAPKAPK31.66271021
28IRAK21.64880768
29PAK61.63845857
30MAP2K41.62960310
31PRPF4B1.58069008
32CDK121.57007505
33CAMKK21.50911944
34CAMKK11.47896352
35BRSK11.46229249
36MET1.45581217
37EIF2AK11.42818839
38MINK11.41290525
39PRKD31.36810348
40RPS6KB21.34951829
41BLK1.34077201
42ACVR1B1.29201643
43KSR11.27796745
44TESK11.26526466
45NTRK21.25263376
46CHEK21.24445746
47SGK21.23645087
48RIPK41.22534085
49YES11.21185738
50ICK1.17699590
51SGK2231.16516164
52SGK4941.16516164
53MAP3K131.15796134
54BRAF1.15416508
55HIPK21.14459179
56CDK51.12722777
57BMPR21.12388450
58MAPK131.11428150
59GRK51.10868589
60ARAF1.10801583
61EPHA21.10684160
62WNK41.08981687
63PLK41.08621833
64EPHB21.08353624
65PIK3CG1.00868442
66MARK10.96941348
67DAPK30.94461870
68PTK2B0.94381170
69MAP3K30.93966597
70NTRK10.92324524
71CAMK2A0.91672532
72DDR20.91638279
73MAP3K60.91167455
74TAOK10.89985994
75SGK30.85593374
76PRKCG0.83540232
77MAPK70.83314596
78RAF10.80447735
79IRAK10.80248703
80INSRR0.80211924
81PHKG10.79220778
82PHKG20.79220778
83ABL20.78672715
84MAPKAPK20.78449119
85FGFR30.78100237
86MAP3K20.77698648
87STK100.76509175
88TYRO30.76074023
89CDK180.75728723
90LATS20.74480753
91STK380.73815619
92PIM10.73400936
93MELK0.72839208
94TNIK0.71276539
95STK240.70902164
96CDK150.70820703
97STK110.67346316
98SIK30.67192516
99PRKD20.66651329
100MUSK0.66331875
101NLK0.64940146
102MAPK120.63102967
103CAMK2B0.62686812
104MATK0.62433423
105CDK140.62172434
106MAPK150.61449906
107CAMK10.61364441
108FES0.60529956
109PKN10.59917117
110FGR0.58970575
111BMX0.58835525
112SGK10.58815580
113CDK11A0.57989376
114BMPR1B0.57682194
115MOS0.56279592
116MYLK0.55759300
117DYRK30.55437699
118SCYL20.52636066
119PDK10.52029786
120LMTK20.51793371
121PDPK10.51695338
122SIK20.51608120
123PDK40.51469570
124PDK30.51469570
125PRKCH0.50069753
126PLK30.49297600
127TSSK60.48191372
128FRK0.47714051
129NEK10.47515047
130PRKCE0.47304539
131PRKG10.46882538
132ERBB40.46437354
133MAP3K70.45775991
134CAMK40.45336485
135JAK20.45171582
136RET0.44795555
137CHEK10.44359127
138TAOK30.44102983
139PDK20.43304339
140PINK10.43223050
141CDK30.43173442
142ADRBK10.43164099
143MAP2K10.42879986
144PRKG20.41481302
145AURKB0.39724722
146MAP2K60.39401184
147PLK10.37339766
148NEK60.36976139
149CSNK1G20.36717053
150FGFR10.35295784
151CLK10.35255047
152TEC0.34417445
153CDK70.33788634
154DMPK0.33200068
155PKN20.32251108
156DYRK1A0.32004163
157MAP3K10.31817372
158RPS6KA30.31192434
159UHMK10.30879721
160CDK80.30281330
161PIK3CA0.27079261
162PNCK0.25132302
163ERBB20.24791543
164MARK20.23795405
165MAP2K30.23379282
166NME10.23246198
167CAMK2G0.22838153
168TNK20.22049863
169FER0.21675839
170PRKCZ0.21591264
171NEK20.21251929
172BCR0.21116390
173FYN0.21111397
174RPS6KA10.19401273

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004608.50512148
2Synaptic vesicle cycle_Homo sapiens_hsa047214.07837427
3Nicotine addiction_Homo sapiens_hsa050333.75646660
4Arginine biosynthesis_Homo sapiens_hsa002203.10017399
5Olfactory transduction_Homo sapiens_hsa047402.90905713
6Long-term potentiation_Homo sapiens_hsa047202.84726999
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.73215113
8Amphetamine addiction_Homo sapiens_hsa050312.71914202
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.70737755
10Circadian entrainment_Homo sapiens_hsa047132.63969436
11Collecting duct acid secretion_Homo sapiens_hsa049662.51632658
12Morphine addiction_Homo sapiens_hsa050322.45053111
13Glutamatergic synapse_Homo sapiens_hsa047242.42951628
14GABAergic synapse_Homo sapiens_hsa047272.35669983
15Salivary secretion_Homo sapiens_hsa049702.23785936
16Steroid biosynthesis_Homo sapiens_hsa001002.14772058
17Dopaminergic synapse_Homo sapiens_hsa047282.08152556
18Arachidonic acid metabolism_Homo sapiens_hsa005902.07356775
19Insulin secretion_Homo sapiens_hsa049112.04100804
20Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.91786039
21Renin secretion_Homo sapiens_hsa049241.90502095
22Oxytocin signaling pathway_Homo sapiens_hsa049211.83056667
23Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.83039316
24Gastric acid secretion_Homo sapiens_hsa049711.82057826
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.81383942
26Long-term depression_Homo sapiens_hsa047301.64663371
27Cholinergic synapse_Homo sapiens_hsa047251.64165185
28Mineral absorption_Homo sapiens_hsa049781.60550303
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.58884461
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56108107
31Serotonergic synapse_Homo sapiens_hsa047261.55601516
32Calcium signaling pathway_Homo sapiens_hsa040201.55399668
33Fat digestion and absorption_Homo sapiens_hsa049751.52892053
34Taste transduction_Homo sapiens_hsa047421.52450374
35GnRH signaling pathway_Homo sapiens_hsa049121.51473485
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.49426480
37Glutathione metabolism_Homo sapiens_hsa004801.48836317
38Sulfur relay system_Homo sapiens_hsa041221.46789200
39Fatty acid biosynthesis_Homo sapiens_hsa000611.45683188
40Fructose and mannose metabolism_Homo sapiens_hsa000511.43833386
41Cocaine addiction_Homo sapiens_hsa050301.43207388
42Vibrio cholerae infection_Homo sapiens_hsa051101.41997352
43Circadian rhythm_Homo sapiens_hsa047101.38802566
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.37706123
45Phototransduction_Homo sapiens_hsa047441.35652646
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.35198602
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.33475454
48Homologous recombination_Homo sapiens_hsa034401.32760680
49Linoleic acid metabolism_Homo sapiens_hsa005911.29431718
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.28789203
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.25216173
52cAMP signaling pathway_Homo sapiens_hsa040241.24383244
53Gap junction_Homo sapiens_hsa045401.16982897
54Oxidative phosphorylation_Homo sapiens_hsa001901.16890079
55Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16294375
56Melanogenesis_Homo sapiens_hsa049161.14351251
57Glioma_Homo sapiens_hsa052141.11958973
58Mismatch repair_Homo sapiens_hsa034301.08997844
59Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.07980448
60Galactose metabolism_Homo sapiens_hsa000521.06753318
61cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05499146
62Vascular smooth muscle contraction_Homo sapiens_hsa042701.05489964
63Arginine and proline metabolism_Homo sapiens_hsa003301.04003790
64Huntingtons disease_Homo sapiens_hsa050161.02856828
65Chemical carcinogenesis_Homo sapiens_hsa052041.02390159
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.01772465
67Estrogen signaling pathway_Homo sapiens_hsa049151.00914648
68Oocyte meiosis_Homo sapiens_hsa041140.99476507
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98546870
70ErbB signaling pathway_Homo sapiens_hsa040120.98393853
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98364797
72Axon guidance_Homo sapiens_hsa043600.96283890
73Sphingolipid metabolism_Homo sapiens_hsa006000.96085991
74Base excision repair_Homo sapiens_hsa034100.94405072
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94283370
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92939635
77Other glycan degradation_Homo sapiens_hsa005110.91162638
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90839165
79Type II diabetes mellitus_Homo sapiens_hsa049300.90583613
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.88088325
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84354376
82Dilated cardiomyopathy_Homo sapiens_hsa054140.81900949
83Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.81357723
84MAPK signaling pathway_Homo sapiens_hsa040100.78935617
85Starch and sucrose metabolism_Homo sapiens_hsa005000.76756273
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76015209
87Caffeine metabolism_Homo sapiens_hsa002320.74864427
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74258022
89Fatty acid degradation_Homo sapiens_hsa000710.73632839
90Basal transcription factors_Homo sapiens_hsa030220.72978708
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72506372
92Cardiac muscle contraction_Homo sapiens_hsa042600.71852543
93Pancreatic secretion_Homo sapiens_hsa049720.69746496
94Butanoate metabolism_Homo sapiens_hsa006500.68083905
95Parkinsons disease_Homo sapiens_hsa050120.67472548
96Ras signaling pathway_Homo sapiens_hsa040140.67357593
97Nucleotide excision repair_Homo sapiens_hsa034200.66681713
98Dorso-ventral axis formation_Homo sapiens_hsa043200.65652086
99PPAR signaling pathway_Homo sapiens_hsa033200.64963043
100Vitamin digestion and absorption_Homo sapiens_hsa049770.64733035
101Glucagon signaling pathway_Homo sapiens_hsa049220.64128226
102Ovarian steroidogenesis_Homo sapiens_hsa049130.62759990
103RNA polymerase_Homo sapiens_hsa030200.61454333
104Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.59310710
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58415106
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.58328108
107Rheumatoid arthritis_Homo sapiens_hsa053230.57896992
108Inositol phosphate metabolism_Homo sapiens_hsa005620.57152551
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56177402
110Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55866852
111Nitrogen metabolism_Homo sapiens_hsa009100.54304899
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53860038
113Rap1 signaling pathway_Homo sapiens_hsa040150.52954584
114Choline metabolism in cancer_Homo sapiens_hsa052310.52449744
115Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51200108
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50629088
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49718916
118Thyroid hormone synthesis_Homo sapiens_hsa049180.47869219
119Renal cell carcinoma_Homo sapiens_hsa052110.47657294
120Retinol metabolism_Homo sapiens_hsa008300.47645658
121Renin-angiotensin system_Homo sapiens_hsa046140.47088044
122Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45285913
123VEGF signaling pathway_Homo sapiens_hsa043700.45235670
124Metabolic pathways_Homo sapiens_hsa011000.44595520
125Neurotrophin signaling pathway_Homo sapiens_hsa047220.43293293
126mTOR signaling pathway_Homo sapiens_hsa041500.43195759
127Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43015145
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42634574
129Fanconi anemia pathway_Homo sapiens_hsa034600.42492034
130Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42458120
131Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42435562
132Histidine metabolism_Homo sapiens_hsa003400.41987706
133Bile secretion_Homo sapiens_hsa049760.41521305
134Glycerolipid metabolism_Homo sapiens_hsa005610.41254007
135B cell receptor signaling pathway_Homo sapiens_hsa046620.39988588
136Fatty acid metabolism_Homo sapiens_hsa012120.39658355
137Ribosome_Homo sapiens_hsa030100.39103346
138p53 signaling pathway_Homo sapiens_hsa041150.37578688
139Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37063816
140Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36833496
141Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35917962
142Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.34468615
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34313120
144Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33915570
145Insulin signaling pathway_Homo sapiens_hsa049100.33759064
146Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33426688
147Drug metabolism - other enzymes_Homo sapiens_hsa009830.33254368
148Wnt signaling pathway_Homo sapiens_hsa043100.32595658
149Ether lipid metabolism_Homo sapiens_hsa005650.31763686
150Endometrial cancer_Homo sapiens_hsa052130.30605989
151ABC transporters_Homo sapiens_hsa020100.30391058
152Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29921534
153Alzheimers disease_Homo sapiens_hsa050100.29247246
154RNA transport_Homo sapiens_hsa030130.29158018
155Sphingolipid signaling pathway_Homo sapiens_hsa040710.28644682
156African trypanosomiasis_Homo sapiens_hsa051430.28335214
157Endocytosis_Homo sapiens_hsa041440.27488175
158Phagosome_Homo sapiens_hsa041450.27278017
159Alcoholism_Homo sapiens_hsa050340.26868186
160Melanoma_Homo sapiens_hsa052180.26693489
161Regulation of autophagy_Homo sapiens_hsa041400.26621389
162Tyrosine metabolism_Homo sapiens_hsa003500.26153129
163Glycerophospholipid metabolism_Homo sapiens_hsa005640.26094453
164Tight junction_Homo sapiens_hsa045300.26073001
165Non-small cell lung cancer_Homo sapiens_hsa052230.25050810
166Non-homologous end-joining_Homo sapiens_hsa034500.24362073
167Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23542278
168Leukocyte transendothelial migration_Homo sapiens_hsa046700.20499493
169Phenylalanine metabolism_Homo sapiens_hsa003600.16052698

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »