KRBA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pattern specification involved in kidney development (GO:0061004)5.13552419
2atrioventricular valve morphogenesis (GO:0003181)4.85910124
3negative regulation of erythrocyte differentiation (GO:0045647)4.73626617
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.41696082
5locomotory exploration behavior (GO:0035641)4.36177785
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.29441076
7apoptotic process involved in morphogenesis (GO:0060561)4.24470323
8cardiac muscle contraction (GO:0060048)4.17054983
9synaptic vesicle maturation (GO:0016188)4.12018891
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.94070983
11cell-substrate adherens junction assembly (GO:0007045)3.88880639
12focal adhesion assembly (GO:0048041)3.88880639
13adherens junction assembly (GO:0034333)3.88259936
14cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.84917073
15creatine metabolic process (GO:0006600)3.76350689
16negative regulation of cell size (GO:0045792)3.75171843
17membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.74610002
18negative regulation of myotube differentiation (GO:0010832)3.74242278
19layer formation in cerebral cortex (GO:0021819)3.73284343
20sarcomere organization (GO:0045214)3.72398970
21cell communication by electrical coupling (GO:0010644)3.69483594
22vocalization behavior (GO:0071625)3.65050878
23cerebellar Purkinje cell differentiation (GO:0021702)3.59573589
24regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.56072119
25mannose metabolic process (GO:0006013)3.54947111
26negative regulation of cytosolic calcium ion concentration (GO:0051481)3.52939812
27regulation of cardioblast differentiation (GO:0051890)3.47037030
28membrane depolarization during action potential (GO:0086010)3.45831035
29regulation of NFAT protein import into nucleus (GO:0051532)3.43631332
30positive regulation of synapse maturation (GO:0090129)3.42226297
31atrial septum morphogenesis (GO:0060413)3.40530860
32regulation of synapse structural plasticity (GO:0051823)3.36003958
33cell-substrate junction assembly (GO:0007044)3.35954451
34regulation of glutamate receptor signaling pathway (GO:1900449)3.35352989
35synaptic vesicle docking involved in exocytosis (GO:0016081)3.34528880
36planar cell polarity pathway involved in neural tube closure (GO:0090179)3.30694753
37cilium or flagellum-dependent cell motility (GO:0001539)3.28706315
38sodium ion export (GO:0071436)3.26804838
39cardiac muscle hypertrophy (GO:0003300)3.26247545
40establishment of nucleus localization (GO:0040023)3.26149249
41cardiac muscle tissue development (GO:0048738)3.24171967
42cellular potassium ion homeostasis (GO:0030007)3.24029522
43muscle filament sliding (GO:0030049)3.23653356
44actin-myosin filament sliding (GO:0033275)3.23653356
45ionotropic glutamate receptor signaling pathway (GO:0035235)3.22563640
46cell-cell junction maintenance (GO:0045217)3.22129193
47semaphorin-plexin signaling pathway (GO:0071526)3.20612665
48coronary vasculature morphogenesis (GO:0060977)3.14343639
49regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.13621801
50neurotransmitter secretion (GO:0007269)3.13525938
51regulation of RNA export from nucleus (GO:0046831)3.11377022
52regulation of translational fidelity (GO:0006450)3.11342016
53regulation of ARF GTPase activity (GO:0032312)3.09929645
54striated muscle hypertrophy (GO:0014897)3.09926610
55insulin-like growth factor receptor signaling pathway (GO:0048009)3.08966646
56regulation of nucleobase-containing compound transport (GO:0032239)3.07382717
57glutamate secretion (GO:0014047)3.03549249
58regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.02167303
59exploration behavior (GO:0035640)3.02033425
60cardiac muscle adaptation (GO:0014887)3.02012417
61cardiac muscle hypertrophy in response to stress (GO:0014898)3.02012417
62muscle hypertrophy in response to stress (GO:0003299)3.02012417
63retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.01915072
64gamma-aminobutyric acid transport (GO:0015812)3.01500903
65ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.01382743
66neuronal action potential propagation (GO:0019227)3.00768079
67synaptic vesicle exocytosis (GO:0016079)3.00223651
68vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.00059626
69glutamate receptor signaling pathway (GO:0007215)2.99330009
70snRNA metabolic process (GO:0016073)2.99056321
71protein localization to synapse (GO:0035418)2.98650177
72cell communication involved in cardiac conduction (GO:0086065)2.98090640
73potassium ion import (GO:0010107)2.97929018
74prepulse inhibition (GO:0060134)2.96890463
75G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.96688867
76histone H4 deacetylation (GO:0070933)2.95474944
77peptidyl-arginine omega-N-methylation (GO:0035247)2.95374961
78apoptotic process involved in development (GO:1902742)2.95307508
79regulation of synaptic vesicle exocytosis (GO:2000300)2.94213323
80regulation of mammary gland epithelial cell proliferation (GO:0033599)2.94016340
81regulation of chromatin binding (GO:0035561)2.92990765
82synaptic transmission, glutamatergic (GO:0035249)2.92538181
83cardiac muscle tissue morphogenesis (GO:0055008)2.92360800
84regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.91743104
85cardiac myofibril assembly (GO:0055003)2.90132674
86regulation of early endosome to late endosome transport (GO:2000641)2.90131431
87proline biosynthetic process (GO:0006561)2.90031148
88neurotransmitter-gated ion channel clustering (GO:0072578)2.89145954
89segment specification (GO:0007379)2.88327487
90regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.87857238
91positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.87378023
92dendritic spine morphogenesis (GO:0060997)2.87013773
93regulation of neuronal synaptic plasticity (GO:0048168)2.86972515
94adult heart development (GO:0007512)2.85747905
95long-term memory (GO:0007616)2.85474864
96positive regulation of histone deacetylation (GO:0031065)2.84643669
97positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.84230717
98dendrite morphogenesis (GO:0048813)2.83911723
99regulation of membrane repolarization (GO:0060306)2.83079705
100cardiac chamber formation (GO:0003207)2.82031812
101sperm motility (GO:0030317)2.81868451
102nucleosome disassembly (GO:0006337)2.81732869
103protein-DNA complex disassembly (GO:0032986)2.81732869
104heart valve formation (GO:0003188)2.80884979
105muscle hypertrophy (GO:0014896)2.78979908
106regulation of the force of heart contraction (GO:0002026)2.78426763
107neuronal ion channel clustering (GO:0045161)2.77834101
108activation of protein kinase A activity (GO:0034199)2.77270619
109regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.76942927
110intracellular estrogen receptor signaling pathway (GO:0030520)2.76803631
111cytoskeletal anchoring at plasma membrane (GO:0007016)2.76074858
112calcium ion import (GO:0070509)2.75600268
113lymph vessel development (GO:0001945)2.74550305
114cardiac muscle cell proliferation (GO:0060038)2.74448539
115regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.74388694
116regulation of actin filament-based movement (GO:1903115)2.73531101
117positive regulation of myotube differentiation (GO:0010831)2.73155661
118regulation of long-term neuronal synaptic plasticity (GO:0048169)2.72758398
119auditory behavior (GO:0031223)2.72386526
120muscle tissue morphogenesis (GO:0060415)2.71519671
121neuromuscular process controlling balance (GO:0050885)2.70292803
122regulation of dendritic spine morphogenesis (GO:0061001)2.69836406
123histone H3-K9 demethylation (GO:0033169)2.68782869
124camera-type eye morphogenesis (GO:0048593)2.68671279
125venous blood vessel morphogenesis (GO:0048845)2.68196048
126striated muscle contraction (GO:0006941)2.67952825
127neuron-neuron synaptic transmission (GO:0007270)2.67647903
128transmission of nerve impulse (GO:0019226)2.67196918
129negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.66937684
130negative regulation of potassium ion transmembrane transport (GO:1901380)2.66884802
131regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.66705406
132cell junction maintenance (GO:0034331)2.66576246
133calcium ion-dependent exocytosis (GO:0017156)2.66114918
134negative regulation of striated muscle cell differentiation (GO:0051154)2.65300119
135negative regulation of inclusion body assembly (GO:0090084)2.64887824
136vascular endothelial growth factor signaling pathway (GO:0038084)2.64802437
137positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.64488141
138positive regulation of blood vessel endothelial cell migration (GO:0043536)2.64268131
139cardiac ventricle formation (GO:0003211)2.63250803
140snRNA processing (GO:0016180)2.63143994
141neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.61965255
142detection of calcium ion (GO:0005513)2.61880208
143actomyosin structure organization (GO:0031032)2.61844939
144cerebellar granule cell differentiation (GO:0021707)2.61733733
145axonal fasciculation (GO:0007413)2.60615420
146negative regulation of organelle assembly (GO:1902116)2.60571257
147regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.60066303
148outflow tract septum morphogenesis (GO:0003148)2.59619893
149cellular protein complex localization (GO:0034629)2.58754024
150regulation of excitatory postsynaptic membrane potential (GO:0060079)2.58515985
151COPI coating of Golgi vesicle (GO:0048205)2.58178503
152Golgi transport vesicle coating (GO:0048200)2.58178503
153endothelial cell chemotaxis (GO:0035767)2.57443725
154neuromuscular junction development (GO:0007528)2.57232815
155membrane depolarization (GO:0051899)2.56970556
156regulation of ARF protein signal transduction (GO:0032012)2.56563103
157neural tube development (GO:0021915)2.56209007
158mitotic G1 DNA damage checkpoint (GO:0031571)2.55705704
159regulation of synaptic vesicle transport (GO:1902803)2.55458985
160striatum development (GO:0021756)2.54889848
161negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.54378651
162positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.53617560
163regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.53315877
164regulation of synapse maturation (GO:0090128)2.52913221
165nucleus localization (GO:0051647)2.52546429
166innervation (GO:0060384)2.52471970
167neuron cell-cell adhesion (GO:0007158)2.52408063
168histone H3 deacetylation (GO:0070932)2.52263970
169cell migration involved in heart development (GO:0060973)2.52227791
170cellular sodium ion homeostasis (GO:0006883)2.51190730
171heart trabecula formation (GO:0060347)2.50612119
1723-UTR-mediated mRNA stabilization (GO:0070935)2.50595213
173regulation of postsynaptic membrane potential (GO:0060078)2.49994102
174membrane repolarization (GO:0086009)2.49894441
175regulation of synaptic transmission, glutamatergic (GO:0051966)2.48661744
176heart morphogenesis (GO:0003007)2.48447522
177myofibril assembly (GO:0030239)2.48354649
178acrosome reaction (GO:0007340)2.48049050
179potassium ion homeostasis (GO:0055075)2.48030892
180cell differentiation in hindbrain (GO:0021533)2.48008437
181activation of JUN kinase activity (GO:0007257)2.47708583
182regulation of calcium ion transmembrane transport (GO:1903169)2.47407371
183regulation of calcium ion transmembrane transporter activity (GO:1901019)2.47407371
184neuron recognition (GO:0008038)2.47151535
185G1 DNA damage checkpoint (GO:0044783)2.47087451
186plasma membrane repair (GO:0001778)2.45885448
187respiratory system process (GO:0003016)2.45631280
188cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.45559110
189hemidesmosome assembly (GO:0031581)2.45159770
190synaptic vesicle endocytosis (GO:0048488)2.43870062
191positive regulation of potassium ion transmembrane transport (GO:1901381)2.43442168
192cell migration in hindbrain (GO:0021535)2.43039374

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.47646309
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.27216462
3VDR_21846776_ChIP-Seq_THP-1_Human3.06593238
4LXR_22292898_ChIP-Seq_THP-1_Human2.91809197
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.84549263
6MYC_22102868_ChIP-Seq_BL_Human2.81980429
7DROSHA_22980978_ChIP-Seq_HELA_Human2.81118772
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.74919975
9TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.61904886
10KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.53118934
11ELK3_25401928_ChIP-Seq_HUVEC_Human2.45742343
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.43459624
13RARB_27405468_Chip-Seq_BRAIN_Mouse2.39243140
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.33831122
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.23844127
16GBX2_23144817_ChIP-Seq_PC3_Human2.21845950
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.20337948
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.18286167
19SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.13988521
20RACK7_27058665_Chip-Seq_MCF-7_Human2.13984759
21EZH2_18974828_ChIP-Seq_MESCs_Mouse2.13774508
22RNF2_18974828_ChIP-Seq_MESCs_Mouse2.13774508
23* REST_21632747_ChIP-Seq_MESCs_Mouse2.10487993
24PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.09989094
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.07066275
26JARID2_20064375_ChIP-Seq_MESCs_Mouse2.03168395
27TCF7_22412390_ChIP-Seq_EML_Mouse2.00420340
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.98935339
29SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.97450926
30MTF2_20144788_ChIP-Seq_MESCs_Mouse1.97029799
31EZH2_27304074_Chip-Seq_ESCs_Mouse1.96911703
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.96562270
33JARID2_20075857_ChIP-Seq_MESCs_Mouse1.93972541
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.88043073
35RNF2_27304074_Chip-Seq_ESCs_Mouse1.86274243
36KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.85150853
37MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.83285827
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.77557786
39P68_20966046_ChIP-Seq_HELA_Human1.77461954
40UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.76275969
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.74194551
42TET1_21451524_ChIP-Seq_MESCs_Mouse1.73412870
43EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.73154486
44SA1_27219007_Chip-Seq_ERYTHROID_Human1.72994699
45SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.72674692
46CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.71753316
47SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.68014901
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.66424505
49REST_18959480_ChIP-ChIP_MESCs_Mouse1.64971760
50EED_16625203_ChIP-ChIP_MESCs_Mouse1.63821391
51CTCF_27219007_Chip-Seq_ERYTHROID_Human1.61674707
52CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.59609002
53ZNF274_21170338_ChIP-Seq_K562_Hela1.58202318
54DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.53066613
55NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.52698978
56SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.51889225
57P300_27058665_Chip-Seq_ZR-75-30cells_Human1.51606262
58NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.49154155
59* NCOR1_26117541_ChIP-Seq_K562_Human1.48416592
60CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.48264509
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45595115
62ZFP281_18757296_ChIP-ChIP_E14_Mouse1.45261957
63CREB1_26743006_Chip-Seq_LNCaP_Human1.43286670
64* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.42605540
65RING1B_27294783_Chip-Seq_ESCs_Mouse1.39722965
66MAF_26560356_Chip-Seq_TH2_Human1.39179290
67ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.38732496
68STAT6_21828071_ChIP-Seq_BEAS2B_Human1.37674390
69ELF1_20517297_ChIP-Seq_JURKAT_Human1.37402748
70CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.36375448
71DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.36338475
72ERG_21242973_ChIP-ChIP_JURKAT_Human1.36322431
73RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.35364206
74KDM2B_26808549_Chip-Seq_K562_Human1.33712397
75AR_19668381_ChIP-Seq_PC3_Human1.33130306
76CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.32192785
77EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.31181701
78MAF_26560356_Chip-Seq_TH1_Human1.30934762
79SMAD4_21799915_ChIP-Seq_A2780_Human1.30364102
80ZFP281_27345836_Chip-Seq_ESCs_Mouse1.30335163
81WT1_25993318_ChIP-Seq_PODOCYTE_Human1.30033642
82SRY_22984422_ChIP-ChIP_TESTIS_Rat1.29202155
83TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28654323
84AR_21572438_ChIP-Seq_LNCaP_Human1.27366837
85* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27365145
86VDR_24763502_ChIP-Seq_THP-1_Human1.27083746
87WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.26793987
88IKZF1_21737484_ChIP-ChIP_HCT116_Human1.24810448
89ZNF263_19887448_ChIP-Seq_K562_Human1.24397161
90CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24002647
91NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.23270108
92* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22819647
93ISL1_27105846_Chip-Seq_CPCs_Mouse1.21535651
94BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.21512942
95MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.21043842
96RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.20904614
97RING1B_27294783_Chip-Seq_NPCs_Mouse1.20869937
98MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.20790646
99E2F7_22180533_ChIP-Seq_HELA_Human1.20505625
100KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20359617
101EP300_21415370_ChIP-Seq_HL-1_Mouse1.20285319
102SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20043967
103THAP11_20581084_ChIP-Seq_MESCs_Mouse1.19187563
104KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18191185
105* SOX2_21211035_ChIP-Seq_LN229_Gbm1.16934985
106DNAJC2_21179169_ChIP-ChIP_NT2_Human1.16934602
107* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16225510
108EGR1_19374776_ChIP-ChIP_THP-1_Human1.16077365
109TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15869694
110CTCF_27219007_Chip-Seq_Bcells_Human1.14613725
111MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14314736
112WDR5_24793694_ChIP-Seq_LNCAP_Human1.13554187
113XRN2_22483619_ChIP-Seq_HELA_Human1.13031253
114TBX20_22328084_ChIP-Seq_HEART_Mouse1.11982343
115TBX20_22080862_ChIP-Seq_HEART_Mouse1.11982343
116* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11489036
117UTX_26944678_Chip-Seq_JUKART_Human1.11424418
118TP53_22127205_ChIP-Seq_IMR90_Human1.11100731
119AHR_22903824_ChIP-Seq_MCF-7_Human1.11028082
120ARNT_22903824_ChIP-Seq_MCF-7_Human1.10716844
121BCOR_27268052_Chip-Seq_Bcells_Human1.10280540
122TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09771392
123* STAT3_23295773_ChIP-Seq_U87_Human1.08705313
124TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08195434
125POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08195434
126PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07158286
127YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06855390
128CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05408678
129CBX2_27304074_Chip-Seq_ESCs_Mouse1.05365570
130SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.05328738
131CIITA_25753668_ChIP-Seq_RAJI_Human1.05291638
132ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05209181
133E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.04626963
134RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03360271
135SMAD4_21741376_ChIP-Seq_HESCs_Human1.03275974
136ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02042473
137SMAD3_21741376_ChIP-Seq_ESCs_Human1.01284534
138* TCF4_23295773_ChIP-Seq_U87_Human1.01145275
139ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00779157
140TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00631007
141SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.00610011
142TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00451992
143ELK4_26923725_Chip-Seq_MESODERM_Mouse1.00399419
144CLOCK_20551151_ChIP-Seq_293T_Human1.00294608
145TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99882257
146* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99262434
147SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.99152803
148SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99079778
149* TP63_22573176_ChIP-Seq_HFKS_Human0.98869985
150SMAD3_21741376_ChIP-Seq_EPCs_Human0.98827405
151RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98111396
152STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97532570
153ZFX_18555785_ChIP-Seq_MESCs_Mouse0.97478055
154KDM2B_26808549_Chip-Seq_DND41_Human0.97375874
155DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.96966622
156BCL6_27268052_Chip-Seq_Bcells_Human0.96916129
157ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.96766060
158KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96334830
159MYC_18358816_ChIP-ChIP_MESCs_Mouse0.95992725
160ESR1_20079471_ChIP-ChIP_T-47D_Human0.95633532
161GATA1_19941827_ChIP-Seq_MEL_Mouse0.95271766
162OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.92960908
163SALL1_21062744_ChIP-ChIP_HESCs_Human0.92879943
164KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91616222
165KDM2B_26808549_Chip-Seq_JURKAT_Human0.91403187
166PIAS1_25552417_ChIP-Seq_VCAP_Human0.91086295
167BCAT_22108803_ChIP-Seq_LS180_Human0.90631406
168SMAD3_21741376_ChIP-Seq_HESCs_Human0.90369726
169P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89548522
170GATA1_26923725_Chip-Seq_HPCs_Mouse0.87845622
171TET1_21490601_ChIP-Seq_MESCs_Mouse0.87095633
172TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.86770432
173KLF4_19829295_ChIP-Seq_ESCs_Human0.86193301
174CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85685028
175GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85600477
176SMC4_20622854_ChIP-Seq_HELA_Human0.85426408
177AR_25329375_ChIP-Seq_VCAP_Human0.85137664

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.77227242
2MP0003705_abnormal_hypodermis_morpholog3.42747647
3MP0003635_abnormal_synaptic_transmissio2.92544841
4MP0000751_myopathy2.88155336
5MP0004145_abnormal_muscle_electrophysio2.79062924
6MP0002822_catalepsy2.66896182
7MP0005410_abnormal_fertilization2.58234724
8MP0005451_abnormal_body_composition2.53177756
9MP0009046_muscle_twitch2.50552866
10MP0004270_analgesia2.43749434
11MP0002249_abnormal_larynx_morphology2.34284747
12MP0000678_abnormal_parathyroid_gland2.31752638
13MP0005076_abnormal_cell_differentiation2.31730828
14MP0005423_abnormal_somatic_nervous2.28508679
15MP0001849_ear_inflammation2.28452932
16MP0002063_abnormal_learning/memory/cond2.23278238
17MP0008260_abnormal_autophagy2.18034100
18MP0009745_abnormal_behavioral_response2.17413215
19MP0003880_abnormal_central_pattern2.15180616
20MP0009278_abnormal_bone_marrow2.09513539
21MP0002837_dystrophic_cardiac_calcinosis2.07305828
22MP0003172_abnormal_lysosome_physiology2.03444104
23MP0003646_muscle_fatigue2.01965726
24MP0002064_seizures2.00430823
25MP0001486_abnormal_startle_reflex1.97796225
26MP0009780_abnormal_chondrocyte_physiolo1.96559686
27MP0006138_congestive_heart_failure1.94263886
28MP0008438_abnormal_cutaneous_collagen1.93201586
29MP0004233_abnormal_muscle_weight1.91704913
30MP0004510_myositis1.88648348
31MP0002272_abnormal_nervous_system1.87932905
32MP0008569_lethality_at_weaning1.85425013
33MP0002572_abnormal_emotion/affect_behav1.82754020
34MP0004036_abnormal_muscle_relaxation1.82690186
35MP0004885_abnormal_endolymph1.82419997
36MP0003279_aneurysm1.78473506
37MP0002909_abnormal_adrenal_gland1.76414767
38MP0002653_abnormal_ependyma_morphology1.72589459
39MP0004215_abnormal_myocardial_fiber1.70459919
40MP0005058_abnormal_lysosome_morphology1.69401101
41MP0004084_abnormal_cardiac_muscle1.67250716
42MP0001958_emphysema1.65417118
43MP0004272_abnormal_basement_membrane1.63698790
44MP0003787_abnormal_imprinting1.61042077
45MP0008961_abnormal_basal_metabolism1.59486756
46MP0000003_abnormal_adipose_tissue1.59248071
47MP0005409_darkened_coat_color1.58505241
48MP0003566_abnormal_cell_adhesion1.58485333
49MP0009384_cardiac_valve_regurgitation1.56866040
50MP0000733_abnormal_muscle_development1.56500346
51MP0003122_maternal_imprinting1.55583973
52MP0002396_abnormal_hematopoietic_system1.54963551
53MP0000778_abnormal_nervous_system1.52269099
54MP0003137_abnormal_impulse_conducting1.50063202
55MP0002734_abnormal_mechanical_nocicepti1.47264626
56MP0006072_abnormal_retinal_apoptosis1.46745127
57MP0002184_abnormal_innervation1.43407042
58MP0005551_abnormal_eye_electrophysiolog1.40989483
59MP0003698_abnormal_male_reproductive1.40068790
60MP0004087_abnormal_muscle_fiber1.39750419
61MP0002269_muscular_atrophy1.39362326
62MP0002067_abnormal_sensory_capabilities1.38408707
63MP0000749_muscle_degeneration1.37400981
64MP0001984_abnormal_olfaction1.36769531
65MP0005623_abnormal_meninges_morphology1.36562243
66MP0002557_abnormal_social/conspecific_i1.33930174
67MP0005670_abnormal_white_adipose1.32732310
68MP0004085_abnormal_heartbeat1.32234697
69MP0008877_abnormal_DNA_methylation1.31859422
70MP0005666_abnormal_adipose_tissue1.31772916
71MP0010030_abnormal_orbit_morphology1.31301815
72MP0005171_absent_coat_pigmentation1.30188301
73MP0000747_muscle_weakness1.29831380
74MP0001348_abnormal_lacrimal_gland1.29345514
75MP0005375_adipose_tissue_phenotype1.29091512
76MP0000955_abnormal_spinal_cord1.29018030
77MP0000750_abnormal_muscle_regeneration1.28553602
78MP0004381_abnormal_hair_follicle1.28445330
79MP0003879_abnormal_hair_cell1.28364166
80MP0004811_abnormal_neuron_physiology1.25674744
81MP0002882_abnormal_neuron_morphology1.24357122
82MP0001968_abnormal_touch/_nociception1.24132448
83MP0001440_abnormal_grooming_behavior1.23251163
84MP0005620_abnormal_muscle_contractility1.22548688
85MP0003283_abnormal_digestive_organ1.22200568
86MP0002106_abnormal_muscle_physiology1.18958871
87MP0004924_abnormal_behavior1.18458083
88MP0005386_behavior/neurological_phenoty1.18458083
89MP0001501_abnormal_sleep_pattern1.16318954
90MP0001730_embryonic_growth_arrest1.16159678
91MP0002234_abnormal_pharynx_morphology1.15433324
92MP0003453_abnormal_keratinocyte_physiol1.13941626
93MP0002152_abnormal_brain_morphology1.13591120
94MP0003634_abnormal_glial_cell1.12178023
95MP0001544_abnormal_cardiovascular_syste1.11232600
96MP0005385_cardiovascular_system_phenoty1.11232600
97MP0000759_abnormal_skeletal_muscle1.09406792
98MP0003984_embryonic_growth_retardation1.09247584
99MP0000767_abnormal_smooth_muscle1.09094006
100MP0003111_abnormal_nucleus_morphology1.07845925
101MP0005187_abnormal_penis_morphology1.07335316
102MP0004130_abnormal_muscle_cell1.06989764
103MP0005369_muscle_phenotype1.06923988
104MP0001661_extended_life_span1.06867408
105MP0001502_abnormal_circadian_rhythm1.06833426
106MP0003091_abnormal_cell_migration1.05606069
107MP0002066_abnormal_motor_capabilities/c1.04286291
108MP0001545_abnormal_hematopoietic_system1.04086697
109MP0005397_hematopoietic_system_phenotyp1.04086697
110MP0000266_abnormal_heart_morphology1.03055991
111MP0003942_abnormal_urinary_system1.01252787
112MP0002088_abnormal_embryonic_growth/wei1.00245984
113MP0005646_abnormal_pituitary_gland1.00173837
114MP0004858_abnormal_nervous_system0.99708826
115MP0002925_abnormal_cardiovascular_devel0.98217987
116MP0000579_abnormal_nail_morphology0.98024688
117MP0009672_abnormal_birth_weight0.95643186
118MP0001672_abnormal_embryogenesis/_devel0.93966739
119MP0005380_embryogenesis_phenotype0.93966739
120MP0010630_abnormal_cardiac_muscle0.90916188
121MP0001299_abnormal_eye_distance/0.90580706
122MP0003861_abnormal_nervous_system0.90560892
123MP0002108_abnormal_muscle_morphology0.89546067
124MP0000013_abnormal_adipose_tissue0.89470098
125MP0005253_abnormal_eye_physiology0.89077119
126MP0000534_abnormal_ureter_morphology0.88779744
127MP0005330_cardiomyopathy0.88652899
128MP0000569_abnormal_digit_pigmentation0.88398498
129MP0001929_abnormal_gametogenesis0.88246734
130MP0003045_fibrosis0.86434994
131MP0002877_abnormal_melanocyte_morpholog0.86149388
132MP0002735_abnormal_chemical_nociception0.84446744
133MP0004808_abnormal_hematopoietic_stem0.84379820
134MP0002127_abnormal_cardiovascular_syste0.84331894
135MP0002229_neurodegeneration0.84286204
136MP0002080_prenatal_lethality0.84156222
137MP0000631_abnormal_neuroendocrine_gland0.83666207
138MP0003329_amyloid_beta_deposits0.83200409
139MP0004185_abnormal_adipocyte_glucose0.82373189
140MP0003385_abnormal_body_wall0.81903349
141MP0002128_abnormal_blood_circulation0.81357792
142MP0002972_abnormal_cardiac_muscle0.80964320
143MP0003119_abnormal_digestive_system0.80679909
144MP0001915_intracranial_hemorrhage0.80616866
145MP0001485_abnormal_pinna_reflex0.80571300
146MP0003115_abnormal_respiratory_system0.80457065
147MP0003121_genomic_imprinting0.79194513
148MP0002752_abnormal_somatic_nervous0.78236493
149MP0003077_abnormal_cell_cycle0.77998917
150MP0003890_abnormal_embryonic-extraembry0.77834771
151MP0000681_abnormal_thyroid_gland0.77830682
152MP0005621_abnormal_cell_physiology0.77340044
153MP0003221_abnormal_cardiomyocyte_apopto0.77114811
154MP0001970_abnormal_pain_threshold0.76844642
155MP0009840_abnormal_foam_cell0.76122199
156MP0000537_abnormal_urethra_morphology0.75876271
157MP0005503_abnormal_tendon_morphology0.75750445
158MP0002733_abnormal_thermal_nociception0.75317380
159MP0008775_abnormal_heart_ventricle0.75116510
160MP0002089_abnormal_postnatal_growth/wei0.75078716
161MP0003633_abnormal_nervous_system0.75000848
162MP0008932_abnormal_embryonic_tissue0.74528327
163MP0000350_abnormal_cell_proliferation0.73037805
164MP0002069_abnormal_eating/drinking_beha0.72528828
165MP0001614_abnormal_blood_vessel0.71850235
166MP0002085_abnormal_embryonic_tissue0.70954129
167MP0005508_abnormal_skeleton_morphology0.70838238

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)4.29055128
2Ventricular tachycardia (HP:0004756)3.59877558
3Focal motor seizures (HP:0011153)3.55656164
4Abnormality of the lower motor neuron (HP:0002366)3.38535727
5Increased connective tissue (HP:0009025)3.26382027
6Centrally nucleated skeletal muscle fibers (HP:0003687)3.24513523
7Truncus arteriosus (HP:0001660)3.24359286
8Dysmetric saccades (HP:0000641)3.22607098
9Obstructive sleep apnea (HP:0002870)3.17382145
10Absent/shortened dynein arms (HP:0200106)3.16037198
11Dynein arm defect of respiratory motile cilia (HP:0012255)3.16037198
12Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.15786041
13Focal seizures (HP:0007359)3.09134586
14Cerebral aneurysm (HP:0004944)3.07378475
15Sudden death (HP:0001699)3.05880996
16Myokymia (HP:0002411)3.00817694
17Exercise-induced muscle cramps (HP:0003710)2.84608729
18Distal lower limb muscle weakness (HP:0009053)2.84426250
19Progressive cerebellar ataxia (HP:0002073)2.82098598
20Protrusio acetabuli (HP:0003179)2.81350023
21Abnormality of the tricuspid valve (HP:0001702)2.81071513
22Visual hallucinations (HP:0002367)2.79674053
23Distal lower limb amyotrophy (HP:0008944)2.78796677
24Abnormality of the aortic arch (HP:0012303)2.77820791
25Ulnar bowing (HP:0003031)2.74283679
26Dysdiadochokinesis (HP:0002075)2.74167608
27Disproportionate tall stature (HP:0001519)2.71784558
28Prolonged QT interval (HP:0001657)2.68854952
29Gaze-evoked nystagmus (HP:0000640)2.67453582
30Action tremor (HP:0002345)2.63892164
31Hyperacusis (HP:0010780)2.62351955
32Difficulty running (HP:0009046)2.59453335
33Elfin facies (HP:0004428)2.58220766
34Muscle hypertrophy of the lower extremities (HP:0008968)2.56325871
35Genetic anticipation (HP:0003743)2.55872072
36Calf muscle hypertrophy (HP:0008981)2.53916923
37Broad-based gait (HP:0002136)2.49001086
38Broad distal phalanx of finger (HP:0009836)2.47055418
39Thin ribs (HP:0000883)2.45092314
40Hyporeflexia of lower limbs (HP:0002600)2.44239908
41Impaired vibration sensation in the lower limbs (HP:0002166)2.42632953
42Renovascular hypertension (HP:0100817)2.41943190
43Metaphyseal cupping (HP:0003021)2.38221154
44Neoplasm of the heart (HP:0100544)2.37399961
45Ventricular fibrillation (HP:0001663)2.36254382
46Abnormality of skeletal muscle fiber size (HP:0012084)2.36093279
47Myopathic facies (HP:0002058)2.34293032
48Abnormality of the calf musculature (HP:0001430)2.33386144
49Bundle branch block (HP:0011710)2.33262916
50Hyperthyroidism (HP:0000836)2.32840589
51Epileptic encephalopathy (HP:0200134)2.32057779
52Mitral regurgitation (HP:0001653)2.31307340
53Congenital malformation of the right heart (HP:0011723)2.30914807
54Double outlet right ventricle (HP:0001719)2.30914807
55Shallow orbits (HP:0000586)2.29415923
56Asymmetric septal hypertrophy (HP:0001670)2.25604330
57Abnormal gallbladder physiology (HP:0012438)2.24519769
58Cholecystitis (HP:0001082)2.24519769
59Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.23291712
60Ankle clonus (HP:0011448)2.23171186
61Urinary bladder sphincter dysfunction (HP:0002839)2.22815456
62Abnormal respiratory motile cilium physiology (HP:0012261)2.22624658
63Right ventricular cardiomyopathy (HP:0011663)2.21865030
64Postural instability (HP:0002172)2.21586480
65Ragged-red muscle fibers (HP:0003200)2.21373667
66Reticulocytosis (HP:0001923)2.21233995
67Myoglobinuria (HP:0002913)2.20606006
68Insomnia (HP:0100785)2.20331650
69Abnormality of ocular smooth pursuit (HP:0000617)2.19229410
70Atelectasis (HP:0100750)2.18938631
71Cervical subluxation (HP:0003308)2.18592247
72Broad face (HP:0000283)2.18469365
73Atrial fibrillation (HP:0005110)2.17969210
74Muscle fiber splitting (HP:0003555)2.17965500
75Bowel incontinence (HP:0002607)2.15857833
76Impaired smooth pursuit (HP:0007772)2.14910378
77Hemiparesis (HP:0001269)2.12497020
78Annular pancreas (HP:0001734)2.12349667
79Febrile seizures (HP:0002373)2.12179861
80Renal duplication (HP:0000075)2.12104301
81Urinary urgency (HP:0000012)2.12060207
82Hemiplegia (HP:0002301)2.11556823
83Absence seizures (HP:0002121)2.11504485
84Lymphangioma (HP:0100764)2.10663100
85Syncope (HP:0001279)2.08935700
86Turricephaly (HP:0000262)2.07981896
87Abnormality of the fingertips (HP:0001211)2.07965496
88Abnormality of the left ventricular outflow tract (HP:0011103)2.07759733
89Subaortic stenosis (HP:0001682)2.07759733
90Scanning speech (HP:0002168)2.07177671
91Stridor (HP:0010307)2.07037256
92Primary atrial arrhythmia (HP:0001692)2.06831007
93Central scotoma (HP:0000603)2.06369778
94Lipoatrophy (HP:0100578)2.06123006
95Atonic seizures (HP:0010819)2.05652952
96Dilated cardiomyopathy (HP:0001644)2.03984704
97Myotonia (HP:0002486)2.03728546
98Abnormal EKG (HP:0003115)2.03501760
99Truncal ataxia (HP:0002078)2.02415076
100Abnormal large intestine physiology (HP:0012700)2.01734167
101Fragile skin (HP:0001030)1.98991310
102Pointed chin (HP:0000307)1.98843649
103Depression (HP:0000716)1.97487372
104Abnormality of the thoracic spine (HP:0100711)1.97192260
105Overriding aorta (HP:0002623)1.97012128
106Peripheral hypomyelination (HP:0007182)1.96966158
107Hypercortisolism (HP:0001578)1.96587253
108Upper limb amyotrophy (HP:0009129)1.96212249
109Distal upper limb amyotrophy (HP:0007149)1.96212249
110Biconcave vertebral bodies (HP:0004586)1.95959186
111Intention tremor (HP:0002080)1.95897323
112Difficulty climbing stairs (HP:0003551)1.95868561
113Abnormal social behavior (HP:0012433)1.95221913
114Impaired social interactions (HP:0000735)1.95221913
115Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.94716319
116Mildly elevated creatine phosphokinase (HP:0008180)1.94334848
117Deep palmar crease (HP:0006191)1.93642012
118Generalized tonic-clonic seizures (HP:0002069)1.93147536
119EMG: neuropathic changes (HP:0003445)1.92994758
120Premature skin wrinkling (HP:0100678)1.92561436
121Dysmetria (HP:0001310)1.91071859
122Aneurysm (HP:0002617)1.88533307
123Nuclear cataract (HP:0100018)1.88062660
124Premature rupture of membranes (HP:0001788)1.88025364
125Type 1 muscle fiber predominance (HP:0003803)1.87768809
126Supraventricular tachycardia (HP:0004755)1.87134847
127Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.86762697
128Long eyelashes (HP:0000527)1.85852737
129Resting tremor (HP:0002322)1.85412652
130Obsessive-compulsive behavior (HP:0000722)1.84701882
131Abnormal atrioventricular conduction (HP:0005150)1.84657224
132Abnormal connection of the cardiac segments (HP:0011545)1.84116755
133Abnormal ventriculo-arterial connection (HP:0011563)1.84116755
134Transposition of the great arteries (HP:0001669)1.84116755
135Selective tooth agenesis (HP:0001592)1.83758673
136Supraventricular arrhythmia (HP:0005115)1.83472775
137Atrophic scars (HP:0001075)1.80433147
138Poor eye contact (HP:0000817)1.80127077
139Macroorchidism (HP:0000053)1.80019893
140Long palpebral fissure (HP:0000637)1.79601679
141Mitral valve prolapse (HP:0001634)1.79059142
142Chronic bronchitis (HP:0004469)1.77888157
143Atrioventricular block (HP:0001678)1.77479359
144Vertebral compression fractures (HP:0002953)1.77441026
145Abnormality of the calcaneus (HP:0008364)1.77199140
146Dialeptic seizures (HP:0011146)1.77091519
147Heart block (HP:0012722)1.76600732
148Abnormality of the foot musculature (HP:0001436)1.76470599
149Foot dorsiflexor weakness (HP:0009027)1.75654667
150Impaired vibratory sensation (HP:0002495)1.75420912
151Short 4th metacarpal (HP:0010044)1.75091306
152Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.75091306
153Spinal rigidity (HP:0003306)1.74601016
154Increased variability in muscle fiber diameter (HP:0003557)1.73347047
155Rhinitis (HP:0012384)1.73053355
156Infertility (HP:0000789)1.71989579
157Flat cornea (HP:0007720)1.71968923
158Proximal amyotrophy (HP:0007126)1.71775555
159Progressive muscle weakness (HP:0003323)1.71377880
160Hypoplastic left heart (HP:0004383)1.70947967
161Midline defect of the nose (HP:0004122)1.70914961
162Hypoplastic ischia (HP:0003175)1.67856865
163Trigonocephaly (HP:0000243)1.67846597
164Hyperventilation (HP:0002883)1.67436004
165Achilles tendon contracture (HP:0001771)1.66827925
166Hypoplasia of the iris (HP:0007676)1.66443886
167Lower limb muscle weakness (HP:0007340)1.65455763
168Bladder diverticulum (HP:0000015)1.64814718
169Hyperkalemia (HP:0002153)1.64777467
170Rimmed vacuoles (HP:0003805)1.64627058
171Ventricular arrhythmia (HP:0004308)1.63978212
172Lower limb amyotrophy (HP:0007210)1.63593497
173Cutaneous finger syndactyly (HP:0010554)1.62629383
174Supranuclear gaze palsy (HP:0000605)1.62141617
175Abnormality of the ischium (HP:0003174)1.60904107
176Drooling (HP:0002307)1.60493121
177Excessive salivation (HP:0003781)1.60493121
178EMG: myopathic abnormalities (HP:0003458)1.58915572
179Spastic gait (HP:0002064)1.58839332

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRKD33.47852781
2NTRK32.92558871
3SMG12.84484478
4EPHA42.76613372
5PRPF4B2.60261028
6PDK42.43387090
7PDK32.43387090
8ICK2.34319894
9PHKG22.33024606
10PHKG12.33024606
11MAP3K42.29888978
12MAP3K92.25003423
13PIM22.12895697
14MARK12.02413513
15NTRK21.96218991
16STK381.79164822
17ERN11.77735406
18OBSCN1.72620286
19CAMK1G1.72519605
20WNK11.67508237
21FGFR41.65640711
22PNCK1.63310098
23PAK61.62971172
24TYRO31.60974351
25TTN1.46485978
26MAP2K31.43009650
27SIK21.41450993
28DAPK21.41087348
29MAP3K71.36784856
30CDC42BPA1.29769608
31MAP2K41.29144402
32MAPK121.27397359
33PINK11.26645491
34MINK11.25551861
35CAMKK11.24843667
36SGK31.20126672
37RIPK11.18948348
38TNIK1.18383542
39MAP3K61.17925502
40LMTK21.17086927
41CDK121.13793382
42RPS6KC11.13079339
43RPS6KL11.13079339
44DMPK1.11653958
45IRAK31.07377572
46PTK2B1.06604720
47MARK21.06380294
48SGK21.04838327
49PRKCH1.03028731
50PDK21.02027967
51SGK4941.00864485
52SGK2231.00864485
53FGFR20.97858742
54CAMK1D0.97496984
55TNK20.95227085
56KSR10.94981120
57KSR20.93710184
58PKN20.93193510
59BRD40.93177535
60UHMK10.92665588
61SIK10.92403470
62CDK50.91778138
63DAPK30.91708537
64MAP2K70.90471121
65INSRR0.88789843
66PDGFRA0.88531205
67RPS6KA60.86424612
68STK110.86416673
69ARAF0.85351789
70CAMK10.84386979
71CAMK40.84180226
72MAPK130.83887953
73MAPK110.81433798
74TRIB30.80596569
75BMX0.80276943
76RET0.79418346
77PAK30.79125705
78PTK60.79103588
79ALK0.78321071
80PTK20.77560934
81EPHB10.77346277
82SGK10.76284072
83RIPK40.75985635
84MAP4K10.74865552
85PRKAA10.73830366
86PDPK10.73598448
87MAP3K100.73304508
88WNK40.70099716
89PRKCG0.69263535
90TAOK10.68664175
91HIPK20.67156672
92MYLK0.67138741
93FGFR10.67136013
94NEK10.63653134
95RPS6KA30.63017850
96MTOR0.62918409
97LATS10.61663828
98CDK40.60837725
99MAP3K10.58216221
100DYRK1B0.57942060
101NTRK10.57738204
102CDK80.57632337
103CAMKK20.57364997
104LATS20.55705221
105PRKD10.55632442
106BCKDK0.55450595
107WNK30.55358577
108IRAK20.54643490
109MAP3K130.54009715
110RPS6KA10.53864388
111KDR0.53530554
112PAK20.53458323
113BRAF0.52972297
114TAOK20.51704729
115TESK10.51299812
116CDK70.51227460
117ROCK20.51132377
118DYRK1A0.51066536
119CAMK2A0.51058980
120DDR20.50337388
121MAPK40.49626448
122LRRK20.49587034
123MAPK100.49153782
124PDK10.48200899
125MAPK150.48078264
126MAP3K80.47863632
127MAPK80.47802219
128NEK90.47170352
129PDGFRB0.47113423
130CDK90.46277472
131PKN10.46086055
132MAP3K110.45448982
133ROCK10.45313215
134STK40.44738388
135GSK3B0.43017151
136CDK60.42799602
137RPS6KA20.41801183
138MAP2K60.41686223
139CDK20.41363748
140TBK10.41092933
141ERBB20.40459039
142PRKDC0.39102456
143CSNK1E0.38963750
144CHEK10.38369013
145PRKCZ0.38188504
146PRKD20.37552479
147FES0.37333900
148BLK0.37290398
149AKT20.37244805
150MAPK70.36946096
151EEF2K0.36878659
152CSNK1D0.36827819
153NME20.32793261

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.56835724
2Circadian entrainment_Homo sapiens_hsa047132.35176949
3Other glycan degradation_Homo sapiens_hsa005112.30367628
4GABAergic synapse_Homo sapiens_hsa047272.15931784
5Long-term potentiation_Homo sapiens_hsa047202.13143151
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.09939204
7Glutamatergic synapse_Homo sapiens_hsa047242.08925547
8Amphetamine addiction_Homo sapiens_hsa050312.07622668
9Olfactory transduction_Homo sapiens_hsa047402.07622363
10Chronic myeloid leukemia_Homo sapiens_hsa052202.03267563
11Morphine addiction_Homo sapiens_hsa050321.99500950
12Insulin secretion_Homo sapiens_hsa049111.97832714
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.93501225
14Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.92196895
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.91534232
16Synaptic vesicle cycle_Homo sapiens_hsa047211.85257759
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.84931737
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.77292422
19Dilated cardiomyopathy_Homo sapiens_hsa054141.76134073
20Acute myeloid leukemia_Homo sapiens_hsa052211.71677301
21Renin secretion_Homo sapiens_hsa049241.66220295
22Sulfur relay system_Homo sapiens_hsa041221.65846655
23Gastric acid secretion_Homo sapiens_hsa049711.64288088
24Oxytocin signaling pathway_Homo sapiens_hsa049211.63847360
25Type II diabetes mellitus_Homo sapiens_hsa049301.61722919
26Dopaminergic synapse_Homo sapiens_hsa047281.61607169
27Salivary secretion_Homo sapiens_hsa049701.59685534
28Non-small cell lung cancer_Homo sapiens_hsa052231.57442789
29Calcium signaling pathway_Homo sapiens_hsa040201.56615075
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.53789320
31Cocaine addiction_Homo sapiens_hsa050301.52353650
32Bladder cancer_Homo sapiens_hsa052191.50417712
33Cardiac muscle contraction_Homo sapiens_hsa042601.50261983
34Cholinergic synapse_Homo sapiens_hsa047251.49788547
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.47980782
36Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.44337310
37Taste transduction_Homo sapiens_hsa047421.43159824
38Glucagon signaling pathway_Homo sapiens_hsa049221.41413464
39Pancreatic cancer_Homo sapiens_hsa052121.39369777
40Focal adhesion_Homo sapiens_hsa045101.38504390
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.35807978
42Dorso-ventral axis formation_Homo sapiens_hsa043201.34166527
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.30164099
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28455381
45Biosynthesis of amino acids_Homo sapiens_hsa012301.27921496
46cAMP signaling pathway_Homo sapiens_hsa040241.27147569
47Nitrogen metabolism_Homo sapiens_hsa009101.24675057
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.23463450
49GnRH signaling pathway_Homo sapiens_hsa049121.20103212
50Estrogen signaling pathway_Homo sapiens_hsa049151.18500942
51Pentose phosphate pathway_Homo sapiens_hsa000301.17634850
52Fructose and mannose metabolism_Homo sapiens_hsa000511.17237644
53Long-term depression_Homo sapiens_hsa047301.15977961
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.13049340
55Gap junction_Homo sapiens_hsa045401.10527055
56Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.09698284
57Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.09402914
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09288904
59Galactose metabolism_Homo sapiens_hsa000521.07165954
60Melanogenesis_Homo sapiens_hsa049161.06621400
61Axon guidance_Homo sapiens_hsa043601.06513097
62Thyroid hormone signaling pathway_Homo sapiens_hsa049191.05902378
63ECM-receptor interaction_Homo sapiens_hsa045121.05214871
64Circadian rhythm_Homo sapiens_hsa047101.04409290
65B cell receptor signaling pathway_Homo sapiens_hsa046621.03422495
66MicroRNAs in cancer_Homo sapiens_hsa052061.02027964
67HIF-1 signaling pathway_Homo sapiens_hsa040661.01583259
68Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.01416019
69Prion diseases_Homo sapiens_hsa050201.00944122
70Small cell lung cancer_Homo sapiens_hsa052221.00858604
71Phototransduction_Homo sapiens_hsa047441.00233567
72Lysine degradation_Homo sapiens_hsa003100.99030115
73Carbon metabolism_Homo sapiens_hsa012000.97577790
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.97075543
75Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.95781671
76Basal cell carcinoma_Homo sapiens_hsa052170.91848649
77ErbB signaling pathway_Homo sapiens_hsa040120.91815927
78Serotonergic synapse_Homo sapiens_hsa047260.91057861
79Colorectal cancer_Homo sapiens_hsa052100.90179881
80Insulin signaling pathway_Homo sapiens_hsa049100.90149471
81mTOR signaling pathway_Homo sapiens_hsa041500.88909278
82Hedgehog signaling pathway_Homo sapiens_hsa043400.88380024
83Fatty acid biosynthesis_Homo sapiens_hsa000610.88372680
84Adherens junction_Homo sapiens_hsa045200.87760384
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.86472643
86Oocyte meiosis_Homo sapiens_hsa041140.85809113
87Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84862010
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84146890
89Insulin resistance_Homo sapiens_hsa049310.84120750
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.84019076
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83336520
92Glioma_Homo sapiens_hsa052140.82857508
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.82597549
94Bile secretion_Homo sapiens_hsa049760.81752684
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81302594
96Glycosaminoglycan degradation_Homo sapiens_hsa005310.80167817
97Proteoglycans in cancer_Homo sapiens_hsa052050.79457295
98Wnt signaling pathway_Homo sapiens_hsa043100.79228287
99Prostate cancer_Homo sapiens_hsa052150.78166288
100MAPK signaling pathway_Homo sapiens_hsa040100.76245329
101Viral carcinogenesis_Homo sapiens_hsa052030.75298831
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74685115
103Inositol phosphate metabolism_Homo sapiens_hsa005620.72880163
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72754112
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72719320
106HTLV-I infection_Homo sapiens_hsa051660.72091353
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.69746380
108mRNA surveillance pathway_Homo sapiens_hsa030150.69536460
109Hepatitis B_Homo sapiens_hsa051610.69168391
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69027966
1112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.68542863
112Tight junction_Homo sapiens_hsa045300.68415513
113Endometrial cancer_Homo sapiens_hsa052130.67653430
114Thyroid hormone synthesis_Homo sapiens_hsa049180.67581879
115AMPK signaling pathway_Homo sapiens_hsa041520.67142529
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65880367
117Pancreatic secretion_Homo sapiens_hsa049720.65608404
118Prolactin signaling pathway_Homo sapiens_hsa049170.64701609
119Pathways in cancer_Homo sapiens_hsa052000.61806547
120Thyroid cancer_Homo sapiens_hsa052160.61583379
121Choline metabolism in cancer_Homo sapiens_hsa052310.60299463
122Arginine biosynthesis_Homo sapiens_hsa002200.58058112
123Hippo signaling pathway_Homo sapiens_hsa043900.57905811
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57739508
125Amoebiasis_Homo sapiens_hsa051460.57439909
126Rap1 signaling pathway_Homo sapiens_hsa040150.56882437
127Vitamin B6 metabolism_Homo sapiens_hsa007500.56737582
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55429771
129DNA replication_Homo sapiens_hsa030300.54933253
130Cell cycle_Homo sapiens_hsa041100.54085471
131Leukocyte transendothelial migration_Homo sapiens_hsa046700.53891361
132Renal cell carcinoma_Homo sapiens_hsa052110.53630484
133Melanoma_Homo sapiens_hsa052180.53549745
134Neurotrophin signaling pathway_Homo sapiens_hsa047220.53136783
135VEGF signaling pathway_Homo sapiens_hsa043700.52999526
136Ovarian steroidogenesis_Homo sapiens_hsa049130.50961711
137Sphingolipid signaling pathway_Homo sapiens_hsa040710.50788251
138Propanoate metabolism_Homo sapiens_hsa006400.49198910
139Endocytosis_Homo sapiens_hsa041440.47938917
140Adipocytokine signaling pathway_Homo sapiens_hsa049200.47627095
141Alcoholism_Homo sapiens_hsa050340.46513754
142Butanoate metabolism_Homo sapiens_hsa006500.45920499
143Notch signaling pathway_Homo sapiens_hsa043300.43857828
144Pyruvate metabolism_Homo sapiens_hsa006200.42901316
145Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42369394
146Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42083074
147Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41634391
148Glycerophospholipid metabolism_Homo sapiens_hsa005640.40669070

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