KPNA7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import, but exhibits different nuclear localization signal binding specificity compared to other members of the family. A pseudogene of this gene has been defined on chromosome 5. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female gonad development (GO:2000194)9.40987568
2piRNA metabolic process (GO:0034587)8.92428615
3oocyte development (GO:0048599)7.50224783
4retinal cone cell development (GO:0046549)7.17770104
5regulation of meiosis (GO:0040020)6.85280437
6positive regulation of histone H3-K4 methylation (GO:0051571)6.82971004
7regulation of histone H3-K9 methylation (GO:0051570)6.64825441
8female gamete generation (GO:0007292)6.48851226
9protein kinase C signaling (GO:0070528)6.44976846
10mitotic metaphase plate congression (GO:0007080)5.93209600
11regulation of exit from mitosis (GO:0007096)5.87107574
12positive regulation of humoral immune response (GO:0002922)5.86592147
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.80931664
14negative regulation of meiosis (GO:0045835)5.80410003
15meiotic cell cycle (GO:0051321)5.77415266
16regulation of steroid hormone secretion (GO:2000831)5.76750856
17glycine transport (GO:0015816)5.70167527
18DNA methylation involved in gamete generation (GO:0043046)5.67253690
19regulation of cell maturation (GO:1903429)5.65408496
20mitotic chromosome condensation (GO:0007076)5.65347391
21negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.65006773
22histone H2A monoubiquitination (GO:0035518)5.47247610
23regulation of meiotic cell cycle (GO:0051445)5.40152977
24oocyte maturation (GO:0001556)5.34409470
25regulation of acrosome reaction (GO:0060046)5.29967408
26regulation of meiosis I (GO:0060631)5.28487045
27regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.26889205
28male meiosis (GO:0007140)5.11192986
29positive regulation of mitotic sister chromatid separation (GO:1901970)5.09112142
30positive regulation of mitotic metaphase/anaphase transition (GO:0045842)5.09112142
31positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)5.09112142
32histone H2A ubiquitination (GO:0033522)4.96447889
33negative regulation of smooth muscle cell differentiation (GO:0051151)4.88860637
34metaphase plate congression (GO:0051310)4.87864871
35attachment of spindle microtubules to kinetochore (GO:0008608)4.85107531
36mitotic sister chromatid segregation (GO:0000070)4.80865610
37positive regulation of gastrulation (GO:2000543)4.78909286
38base-excision repair, AP site formation (GO:0006285)4.77521918
39regulation of RIG-I signaling pathway (GO:0039535)4.66548143
40negative regulation of hormone biosynthetic process (GO:0032353)4.65726928
41negative regulation of hormone metabolic process (GO:0032351)4.65726928
42DNA damage induced protein phosphorylation (GO:0006975)4.62419448
43regulation of histone H3-K27 methylation (GO:0061085)4.61785905
44establishment of chromosome localization (GO:0051303)4.61660483
45glycerophospholipid catabolic process (GO:0046475)4.59983623
46centriole replication (GO:0007099)4.59174924
47multicellular organism reproduction (GO:0032504)4.58220885
48pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.56137346
49negative regulation of meiotic cell cycle (GO:0051447)4.53255513
50regulation of sister chromatid cohesion (GO:0007063)4.47515773
51maturation of 5.8S rRNA (GO:0000460)4.47038656
52negative regulation of reproductive process (GO:2000242)4.46406046
53regulation of retinoic acid receptor signaling pathway (GO:0048385)4.42303030
54protein K6-linked ubiquitination (GO:0085020)4.35357872
55citrulline biosynthetic process (GO:0019240)4.27180038
56positive regulation of histone methylation (GO:0031062)4.26049749
57primitive streak formation (GO:0090009)4.25149706
58binding of sperm to zona pellucida (GO:0007339)4.24492272
59synapsis (GO:0007129)4.23741188
60positive regulation of reproductive process (GO:2000243)4.21828591
61meiotic chromosome segregation (GO:0045132)4.17672492
62regulation of steroid hormone biosynthetic process (GO:0090030)4.16299778
63L-amino acid import (GO:0043092)4.08122820
64regulation of DNA methylation (GO:0044030)4.04729532
65positive regulation of megakaryocyte differentiation (GO:0045654)4.03666753
66microtubule severing (GO:0051013)4.03135119
67regulation of histone H3-K4 methylation (GO:0051569)4.00561129
68negative regulation of DNA-templated transcription, elongation (GO:0032785)4.00132348
69negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.00132348
70type B pancreatic cell development (GO:0003323)3.96388006
71gene silencing by RNA (GO:0031047)3.96099200
72female gonad development (GO:0008585)3.95124010
73regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.92636727
74protein localization to kinetochore (GO:0034501)3.86716064
75sister chromatid segregation (GO:0000819)3.83395769
76DNA alkylation (GO:0006305)3.82472150
77DNA methylation (GO:0006306)3.82472150
78notochord development (GO:0030903)3.79981275
79regulation of transforming growth factor beta2 production (GO:0032909)3.79607090
80phosphorelay signal transduction system (GO:0000160)3.77913071
81pyrimidine nucleotide catabolic process (GO:0006244)3.77795046
82chromosome segregation (GO:0007059)3.77733708
83regulation of histone methylation (GO:0031060)3.76312771
84DNA damage response, signal transduction resulting in transcription (GO:0042772)3.75760227
85DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.75121616
86protein localization to chromosome, centromeric region (GO:0071459)3.74654524
87synaptonemal complex assembly (GO:0007130)3.74187298
88single fertilization (GO:0007338)3.73722473
89CENP-A containing nucleosome assembly (GO:0034080)3.69865845
90regulation of glucocorticoid metabolic process (GO:0031943)3.68845680
91protein localization to chromosome (GO:0034502)3.66441483
92regulation of reproductive process (GO:2000241)3.63832447
93regulation of spindle organization (GO:0090224)3.61118717
94negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.58879209
95chromosome organization involved in meiosis (GO:0070192)3.57018638
96positive regulation of meiosis (GO:0045836)3.56584881
97phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.55142801
98male meiosis I (GO:0007141)3.54378295
99chromatin remodeling at centromere (GO:0031055)3.53056642
100regulation of mitotic spindle organization (GO:0060236)3.52958063
101positive regulation of uterine smooth muscle contraction (GO:0070474)3.51043604
102spindle checkpoint (GO:0031577)3.50765276
103regulation of calcium ion-dependent exocytosis (GO:0017158)3.50447249
104negative regulation of execution phase of apoptosis (GO:1900118)3.49138663
105positive regulation of DNA-dependent DNA replication (GO:2000105)3.47280710
106regulation of chromosome segregation (GO:0051983)3.46763095
107gene silencing (GO:0016458)3.46680653
108translesion synthesis (GO:0019985)3.43555288
109labyrinthine layer development (GO:0060711)3.41099341
110DNA replication-independent nucleosome assembly (GO:0006336)3.39458895
111DNA replication-independent nucleosome organization (GO:0034724)3.39458895
112stress granule assembly (GO:0034063)3.38937402
113positive regulation of chromosome segregation (GO:0051984)3.38931055
114positive regulation of meiotic cell cycle (GO:0051446)3.38432617
115regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.36066450
116sperm-egg recognition (GO:0035036)3.35691230
117reproduction (GO:0000003)3.35035591
118fertilization (GO:0009566)3.32041623
119phosphatidylglycerol biosynthetic process (GO:0006655)3.30258291
120histone exchange (GO:0043486)3.30043300
121positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.29780604
122chaperone-mediated protein transport (GO:0072321)3.28881650
123synaptonemal complex organization (GO:0070193)3.28498460
124regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.28269003
125DNA replication-dependent nucleosome assembly (GO:0006335)3.27955808
126DNA replication-dependent nucleosome organization (GO:0034723)3.27955808
127oogenesis (GO:0048477)3.27637906
128negative regulation of cell division (GO:0051782)3.27396613
129negative regulation of histone modification (GO:0031057)3.27396366
130regulation of corticosteroid hormone secretion (GO:2000846)3.27191722
131regulation of spindle checkpoint (GO:0090231)3.26814685
132negative regulation of nuclear division (GO:0051784)3.25442061
133N-terminal protein amino acid acetylation (GO:0006474)3.24552994
134regulation of chromatin silencing (GO:0031935)3.24500966
135mitotic nuclear envelope disassembly (GO:0007077)3.23258184
136positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.20329734
137regulation of hypersensitivity (GO:0002883)3.18346461
138nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.16448264
139somite rostral/caudal axis specification (GO:0032525)3.14912568
140mitotic spindle checkpoint (GO:0071174)3.13981046
141negative regulation of cAMP-mediated signaling (GO:0043951)3.13816631
142ovulation cycle (GO:0042698)3.13730709
143negative regulation of histone methylation (GO:0031061)3.13527001
144centriole assembly (GO:0098534)3.13068028
145parturition (GO:0007567)3.12100531
146interkinetic nuclear migration (GO:0022027)3.10727186
147mitotic sister chromatid cohesion (GO:0007064)3.10637444
148meiotic nuclear division (GO:0007126)3.09746079
149DNA replication checkpoint (GO:0000076)3.09263146
150membrane disassembly (GO:0030397)3.07008593
151nuclear envelope disassembly (GO:0051081)3.07008593
152relaxation of smooth muscle (GO:0044557)3.06982509
153regulation of G2/M transition of mitotic cell cycle (GO:0010389)3.04377848
154neuron fate determination (GO:0048664)3.03633627
155histone H3-K9 demethylation (GO:0033169)3.03473742
156regulation of mononuclear cell migration (GO:0071675)3.02696393
157meiotic cell cycle process (GO:1903046)3.02143548
158negative regulation of chromosome segregation (GO:0051985)3.02050920
159regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.01547680
160regulation of RNA export from nucleus (GO:0046831)3.01204244

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.82733218
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.56432442
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.45313555
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.21749492
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.18250267
6* KAP1_22055183_ChIP-Seq_ESCs_Mouse3.86977118
7AR_21909140_ChIP-Seq_LNCAP_Human3.44021714
8E2F7_22180533_ChIP-Seq_HELA_Human3.31150969
9SALL1_21062744_ChIP-ChIP_HESCs_Human3.24784016
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.24539511
11SMAD_19615063_ChIP-ChIP_OVARY_Human3.21444650
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.11276148
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.11276148
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.11276148
15GATA1_26923725_Chip-Seq_HPCs_Mouse2.74415999
16NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.48239061
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.37518675
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.24467795
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.13805775
20EZH2_22144423_ChIP-Seq_EOC_Human2.10355963
21MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse2.05175719
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.03346206
23E2F4_17652178_ChIP-ChIP_JURKAT_Human2.00312774
24IGF1R_20145208_ChIP-Seq_DFB_Human1.83526991
25MYC_18940864_ChIP-ChIP_HL60_Human1.81684089
26RUNX1_26923725_Chip-Seq_HPCs_Mouse1.81316330
27GBX2_23144817_ChIP-Seq_PC3_Human1.80281708
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78951092
29LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75270363
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.73840894
31RNF2_27304074_Chip-Seq_NSC_Mouse1.72850819
32BP1_19119308_ChIP-ChIP_Hs578T_Human1.70216244
33CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68484704
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67400568
35MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.63840507
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.62293849
37TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.56681349
38STAT6_21828071_ChIP-Seq_BEAS2B_Human1.53941956
39RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50163455
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.48136058
41STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.44183145
42STAT1_17558387_ChIP-Seq_HELA_Human1.43641687
43ELK4_26923725_Chip-Seq_MESODERM_Mouse1.39854098
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.38778876
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.35764003
46EP300_21415370_ChIP-Seq_HL-1_Mouse1.35525828
47CDX2_22108803_ChIP-Seq_LS180_Human1.35053105
48GATA3_21867929_ChIP-Seq_TH1_Mouse1.33668092
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30155075
50SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28759961
51FOXM1_26456572_ChIP-Seq_MCF-7_Human1.26076980
52HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.26048690
53MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.25691717
54NANOG_18555785_Chip-Seq_ESCs_Mouse1.25568658
55CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.23779476
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21853598
57SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.21182152
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20437526
59CBP_20019798_ChIP-Seq_JUKART_Human1.20314357
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20314357
61RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.19864504
62NFE2_27457419_Chip-Seq_LIVER_Mouse1.19094126
63CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.17563633
64* STAT3_23295773_ChIP-Seq_U87_Human1.16643634
65NFYA_21822215_ChIP-Seq_K562_Human1.16568042
66KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.16342312
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15815913
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15364192
69TCF4_23295773_ChIP-Seq_U87_Human1.14459563
70PRDM14_20953172_ChIP-Seq_ESCs_Human1.12538982
71AUTS2_25519132_ChIP-Seq_293T-REX_Human1.12533965
72STAT3_18555785_Chip-Seq_ESCs_Mouse1.12498109
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.11689792
74FUS_26573619_Chip-Seq_HEK293_Human1.11593277
75PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.10157418
76KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.10134120
77CTCF_18555785_Chip-Seq_ESCs_Mouse1.10085285
78KLF4_18555785_Chip-Seq_ESCs_Mouse1.08856359
79PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08767209
80KDM2B_26808549_Chip-Seq_REH_Human1.07127880
81SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.06784908
82IRF1_19129219_ChIP-ChIP_H3396_Human1.05921278
83NANOG_21062744_ChIP-ChIP_HESCs_Human1.05837179
84NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.04978346
85AR_25329375_ChIP-Seq_VCAP_Human1.03814399
86EWS_26573619_Chip-Seq_HEK293_Human1.03519992
87NMYC_18555785_Chip-Seq_ESCs_Mouse1.03293760
88TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.03113072
89CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02927196
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02832637
91NANOG_20526341_ChIP-Seq_ESCs_Human1.00096053
92SOX2_18555785_Chip-Seq_ESCs_Mouse0.99956174
93ESRRB_18555785_Chip-Seq_ESCs_Mouse0.99927395
94SMAD4_21741376_ChIP-Seq_EPCs_Human0.99679201
95SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.98566160
96SMAD4_21799915_ChIP-Seq_A2780_Human0.97994530
97AR_21572438_ChIP-Seq_LNCaP_Human0.97981828
98TBL1_22424771_ChIP-Seq_293T_Human0.97491521
99GF1_26923725_Chip-Seq_HPCs_Mouse0.97203013
100GF1B_26923725_Chip-Seq_HPCs_Mouse0.96854595
101TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95767984
102POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95767984
103CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95563006
104ESR1_15608294_ChIP-ChIP_MCF-7_Human0.95387251
105HNFA_21074721_ChIP-Seq_CACO-2_Human0.94752467
106FOXH1_21741376_ChIP-Seq_EPCs_Human0.94493463
107RUNX2_22187159_ChIP-Seq_PCA_Human0.94135195
108TAL1_26923725_Chip-Seq_HPCs_Mouse0.94066482
109KAP1_27257070_Chip-Seq_ESCs_Mouse0.94004702
110FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93977620
111ZFX_18555785_Chip-Seq_ESCs_Mouse0.93562083
112TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.92821819
113TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.91809171
114CTBP2_25329375_ChIP-Seq_LNCAP_Human0.90737825
115MYCN_18555785_ChIP-Seq_MESCs_Mouse0.90541458
116ESR1_20079471_ChIP-ChIP_T-47D_Human0.90014429
117EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.90005614
118CBP_21632823_ChIP-Seq_H3396_Human0.89594895
119OCT4_18555785_Chip-Seq_ESCs_Mouse0.89326597
120GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.89149664
121ETV1_20927104_ChIP-Seq_GIST48_Human0.87431128
122LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86796772
123GATA3_26560356_Chip-Seq_TH1_Human0.86427025
124MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.86395426
125CMYC_18555785_Chip-Seq_ESCs_Mouse0.86285528
126BMI1_23680149_ChIP-Seq_NPCS_Mouse0.86244406
127GATA1_19941827_ChIP-Seq_MEL86_Mouse0.86203391
128TP63_19390658_ChIP-ChIP_HaCaT_Human0.85840646
129ESET_19884257_ChIP-Seq_ESCs_Mouse0.85619034
130HTT_18923047_ChIP-ChIP_STHdh_Human0.85548737
131GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.85481740
132PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85479049
133AHR_22903824_ChIP-Seq_MCF-7_Human0.83956299
134EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.83426152
135NR3C1_23031785_ChIP-Seq_PC12_Mouse0.80501921
136SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.76989096
137SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.75197884
138CREB1_15753290_ChIP-ChIP_HEK293T_Human0.73965557
139PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.73267542
140PKCTHETA_26484144_Chip-Seq_BREAST_Human0.72819108
141SALL4_22934838_ChIP-ChIP_CD34+_Human0.72497836
142KLF4_19829295_ChIP-Seq_ESCs_Human0.71364051
143SMAD3_21741376_ChIP-Seq_EPCs_Human0.70950058
144P300_19829295_ChIP-Seq_ESCs_Human0.67943858
145FOXO3_23340844_ChIP-Seq_DLD1_Human0.67888240
146KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.67511197
147ZNF217_24962896_ChIP-Seq_MCF-7_Human0.67490589
148DROSHA_22980978_ChIP-Seq_HELA_Human0.66404883
149NANOG_18555785_ChIP-Seq_MESCs_Mouse0.65297750
150TP53_16413492_ChIP-PET_HCT116_Human0.64982700
151STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.64907686
152KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.64455256
153TP53_22573176_ChIP-Seq_HFKS_Human0.63973587
154* SMRT_27268052_Chip-Seq_Bcells_Human0.63648265
155ARNT_22903824_ChIP-Seq_MCF-7_Human0.62359643
156SOX2_21211035_ChIP-Seq_LN229_Gbm0.61297874
157REST_21632747_ChIP-Seq_MESCs_Mouse0.60214762
158TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.58623305
159ZNF274_21170338_ChIP-Seq_K562_Hela0.58458720
160EZH2_27304074_Chip-Seq_ESCs_Mouse0.57872825
161NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.57513935

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect7.02061081
2MP0003646_muscle_fatigue6.19076926
3MP0005451_abnormal_body_composition5.41285950
4MP0002102_abnormal_ear_morphology4.79256560
5MP0008789_abnormal_olfactory_epithelium4.13877893
6MP0008877_abnormal_DNA_methylation3.83982143
7MP0003693_abnormal_embryo_hatching3.71635875
8MP0005394_taste/olfaction_phenotype3.69515676
9MP0005499_abnormal_olfactory_system3.69515676
10MP0002139_abnormal_hepatobiliary_system3.32695492
11MP0008057_abnormal_DNA_replication3.19277641
12MP0005395_other_phenotype3.15871262
13MP0010094_abnormal_chromosome_stability3.11982161
14MP0003890_abnormal_embryonic-extraembry3.09422155
15MP0003699_abnormal_female_reproductive3.01301242
16MP0001119_abnormal_female_reproductive2.97204653
17MP0002138_abnormal_hepatobiliary_system2.79980693
18MP0002653_abnormal_ependyma_morphology2.61344772
19MP0003111_abnormal_nucleus_morphology2.60048340
20MP0003077_abnormal_cell_cycle2.54044210
21MP0003879_abnormal_hair_cell2.47237220
22MP0003123_paternal_imprinting2.42914513
23MP0001929_abnormal_gametogenesis2.42323739
24MP0004957_abnormal_blastocyst_morpholog2.35837724
25MP0003787_abnormal_imprinting2.30318454
26MP0000653_abnormal_sex_gland2.29095613
27MP0002234_abnormal_pharynx_morphology2.25877529
28MP0000579_abnormal_nail_morphology2.23732929
29MP0003121_genomic_imprinting2.22298971
30MP0002249_abnormal_larynx_morphology2.18934742
31MP0005646_abnormal_pituitary_gland2.15485643
32MP0002210_abnormal_sex_determination2.08913247
33MP0003183_abnormal_peptide_metabolism2.06347177
34MP0005408_hypopigmentation2.01742449
35MP0006292_abnormal_olfactory_placode1.93428585
36MP0003315_abnormal_perineum_morphology1.85848793
37MP0000566_synostosis1.76944728
38MP0005410_abnormal_fertilization1.68376325
39MP0003937_abnormal_limbs/digits/tail_de1.63806114
40MP0008932_abnormal_embryonic_tissue1.61429157
41MP0002161_abnormal_fertility/fecundity1.61403820
42MP0009840_abnormal_foam_cell1.53856024
43MP0010307_abnormal_tumor_latency1.49108105
44MP0000462_abnormal_digestive_system1.46673222
45MP0001529_abnormal_vocalization1.45098552
46MP0001145_abnormal_male_reproductive1.43842973
47MP0001905_abnormal_dopamine_level1.37087459
48MP0002160_abnormal_reproductive_system1.34662520
49MP0003252_abnormal_bile_duct1.33033102
50MP0001293_anophthalmia1.31375349
51MP0000762_abnormal_tongue_morphology1.24373427
52MP0010368_abnormal_lymphatic_system1.21648840
53MP0002085_abnormal_embryonic_tissue1.17443976
54MP0005187_abnormal_penis_morphology1.16401888
55MP0005310_abnormal_salivary_gland1.14702813
56MP0002233_abnormal_nose_morphology1.11696093
57MP0002295_abnormal_pulmonary_circulatio1.07806139
58MP0010386_abnormal_urinary_bladder1.06318815
59MP0008260_abnormal_autophagy1.06081791
60MP0004185_abnormal_adipocyte_glucose1.05661531
61MP0001730_embryonic_growth_arrest1.04002622
62MP0000639_abnormal_adrenal_gland1.03410436
63MP0000678_abnormal_parathyroid_gland1.02372490
64MP0001984_abnormal_olfaction1.02255493
65MP0004510_myositis1.01408420
66MP0000350_abnormal_cell_proliferation1.00682122
67MP0001986_abnormal_taste_sensitivity1.00580515
68MP0010678_abnormal_skin_adnexa0.99944291
69MP0005257_abnormal_intraocular_pressure0.98484252
70MP0004142_abnormal_muscle_tone0.98014702
71MP0004264_abnormal_extraembryonic_tissu0.93097479
72MP0001915_intracranial_hemorrhage0.92795197
73MP0001697_abnormal_embryo_size0.92331550
74MP0002272_abnormal_nervous_system0.91184574
75MP0004145_abnormal_muscle_electrophysio0.90722795
76MP0005085_abnormal_gallbladder_physiolo0.89632492
77MP0003950_abnormal_plasma_membrane0.89238580
78MP0003119_abnormal_digestive_system0.88568111
79MP0002084_abnormal_developmental_patter0.87147276
80MP0001919_abnormal_reproductive_system0.87051296
81MP0006276_abnormal_autonomic_nervous0.85493232
82MP0003698_abnormal_male_reproductive0.83760976
83MP0001346_abnormal_lacrimal_gland0.83247691
84MP0001666_abnormal_nutrient_absorption0.82044092
85MP0001664_abnormal_digestion0.81824294
86MP0002019_abnormal_tumor_incidence0.81721924
87MP0005380_embryogenesis_phenotype0.79537920
88MP0001672_abnormal_embryogenesis/_devel0.79537920
89MP0006072_abnormal_retinal_apoptosis0.78118289
90MP0005389_reproductive_system_phenotype0.77760515
91MP0009697_abnormal_copulation0.77747291
92MP0003329_amyloid_beta_deposits0.77258590
93MP0010234_abnormal_vibrissa_follicle0.76371288
94MP0003868_abnormal_feces_composition0.75592125
95MP0008007_abnormal_cellular_replicative0.75403882
96MP0009384_cardiac_valve_regurgitation0.75306459
97MP0003136_yellow_coat_color0.75248840
98MP0003453_abnormal_keratinocyte_physiol0.74993384
99MP0002282_abnormal_trachea_morphology0.74621844
100MP0002177_abnormal_outer_ear0.73980131
101MP0000427_abnormal_hair_cycle0.73097317
102MP0005551_abnormal_eye_electrophysiolog0.72932661
103MP0002932_abnormal_joint_morphology0.71507239
104MP0003755_abnormal_palate_morphology0.70860712
105MP0003941_abnormal_skin_development0.69705366
106MP0002796_impaired_skin_barrier0.69439386
107MP0001324_abnormal_eye_pigmentation0.67816179
108MP0003656_abnormal_erythrocyte_physiolo0.66286464
109MP0000613_abnormal_salivary_gland0.66127711
110MP0000049_abnormal_middle_ear0.65776500
111MP0008058_abnormal_DNA_repair0.64896991
112MP0000490_abnormal_crypts_of0.64653349
113MP0004782_abnormal_surfactant_physiolog0.64339135
114MP0002877_abnormal_melanocyte_morpholog0.64006700
115MP0009379_abnormal_foot_pigmentation0.62761934
116MP0004270_analgesia0.60692417
117MP0005501_abnormal_skin_physiology0.60010471
118MP0005621_abnormal_cell_physiology0.58760685
119MP0002837_dystrophic_cardiac_calcinosis0.58283779
120MP0002089_abnormal_postnatal_growth/wei0.57074666
121MP0010030_abnormal_orbit_morphology0.55720557
122MP0005647_abnormal_sex_gland0.55665377
123MP0001963_abnormal_hearing_physiology0.55636895
124MP0005360_urolithiasis0.53883770
125MP0002116_abnormal_craniofacial_bone0.53413745
126MP0009250_abnormal_appendicular_skeleto0.52682939
127MP0001502_abnormal_circadian_rhythm0.52443007
128MP0000631_abnormal_neuroendocrine_gland0.52276051
129MP0005075_abnormal_melanosome_morpholog0.51922752
130MP0002127_abnormal_cardiovascular_syste0.50049475
131MP0001851_eye_inflammation0.49818622
132MP0002168_other_aberrant_phenotype0.48948245
133MP0000015_abnormal_ear_pigmentation0.48045788
134MP0003861_abnormal_nervous_system0.46498544
135MP0004036_abnormal_muscle_relaxation0.46412613
136MP0002332_abnormal_exercise_endurance0.45493810
137MP0002109_abnormal_limb_morphology0.45254867
138MP0005384_cellular_phenotype0.45051313
139MP0005076_abnormal_cell_differentiation0.44918882
140MP0002080_prenatal_lethality0.43935245
141MP0002928_abnormal_bile_duct0.42766627
142MP0004043_abnormal_pH_regulation0.42387658
143MP0002734_abnormal_mechanical_nocicepti0.42195139
144MP0003935_abnormal_craniofacial_develop0.41944117
145MP0002269_muscular_atrophy0.41795050
146MP0003959_abnormal_lean_body0.41184581
147MP0004859_abnormal_synaptic_plasticity0.40621339
148MP0005381_digestive/alimentary_phenotyp0.40234461
149MP0000377_abnormal_hair_follicle0.40123549
150MP0005319_abnormal_enzyme/_coenzyme0.39041788
151MP0002090_abnormal_vision0.38783175
152MP0004381_abnormal_hair_follicle0.38542577
153MP0000733_abnormal_muscle_development0.37816264
154MP0002873_normal_phenotype0.37630120
155MP0000428_abnormal_craniofacial_morphol0.37306102
156MP0002169_no_abnormal_phenotype0.37121173
157MP0006138_congestive_heart_failure0.36544303
158MP0003984_embryonic_growth_retardation0.36522717
159MP0005503_abnormal_tendon_morphology0.36467828

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)7.95167403
2Osteomalacia (HP:0002749)5.13843350
3Abnormality of abdominal situs (HP:0011620)5.09938118
4Abdominal situs inversus (HP:0003363)5.09938118
5Cortical dysplasia (HP:0002539)5.02941539
6Premature ovarian failure (HP:0008209)4.93543723
7Hypophosphatemic rickets (HP:0004912)4.50262398
8Chromsome breakage (HP:0040012)4.46767410
9Birth length less than 3rd percentile (HP:0003561)4.44103144
10Flat capital femoral epiphysis (HP:0003370)4.40169396
11Breast hypoplasia (HP:0003187)4.38266331
12Infertility (HP:0000789)4.33927804
13Papillary thyroid carcinoma (HP:0002895)4.31151676
14Secondary amenorrhea (HP:0000869)4.29870969
15Adrenal hypoplasia (HP:0000835)4.20048578
16Chromosomal breakage induced by crosslinking agents (HP:0003221)4.11065021
17Shawl scrotum (HP:0000049)4.06857029
18Abnormality of the labia minora (HP:0012880)3.99215547
19Septo-optic dysplasia (HP:0100842)3.95271520
20Patellar aplasia (HP:0006443)3.90204614
21Azoospermia (HP:0000027)3.82914545
22Aplasia/Hypoplasia of the patella (HP:0006498)3.56981140
23Hypergonadotropic hypogonadism (HP:0000815)3.55550256
24Pulmonary fibrosis (HP:0002206)3.54300879
25Median cleft lip (HP:0000161)3.51989266
26Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.51451305
27Facial hemangioma (HP:0000329)3.46458198
28Arterial tortuosity (HP:0005116)3.38233288
29Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.33628665
30Gonadotropin excess (HP:0000837)3.25639137
31Apathy (HP:0000741)3.24771862
32Absent septum pellucidum (HP:0001331)3.24356437
33Hypokinesia (HP:0002375)3.23783119
34Aplasia/Hypoplasia of the breasts (HP:0010311)3.18629742
35Insulin-resistant diabetes mellitus (HP:0000831)3.15692727
36Diminished motivation (HP:0000745)3.15360859
37Aplasia/Hypoplasia of the macula (HP:0008059)3.14953203
38Breast aplasia (HP:0100783)3.13685782
39Abnormality of chromosome segregation (HP:0002916)3.03647444
40Abnormality of the fovea (HP:0000493)3.00462317
41Short tibia (HP:0005736)2.99022949
42Vascular tortuosity (HP:0004948)2.91779357
43Abnormal spermatogenesis (HP:0008669)2.88878792
44Aplasia/Hypoplasia affecting the retina (HP:0008061)2.88063715
45Cholecystitis (HP:0001082)2.87283267
46Abnormal gallbladder physiology (HP:0012438)2.87283267
47Spinal cord compression (HP:0002176)2.85410951
48Oligodactyly (hands) (HP:0001180)2.79020077
49Aplasia/Hypoplasia of the fovea (HP:0008060)2.75529504
50Hypoplasia of the fovea (HP:0007750)2.75529504
51Spondylolisthesis (HP:0003302)2.74851472
52Abnormality of the septum pellucidum (HP:0007375)2.72452593
53Enlarged penis (HP:0000040)2.68370042
54Truncal obesity (HP:0001956)2.66947904
55Urethral obstruction (HP:0000796)2.66935763
56Primary amenorrhea (HP:0000786)2.66407228
57Aplasia/Hypoplasia of the tibia (HP:0005772)2.63516508
58Lower limb hyperreflexia (HP:0002395)2.63512453
59Capillary hemangiomas (HP:0005306)2.61968493
60Metaphyseal irregularity (HP:0003025)2.61703836
61Conjunctival telangiectasia (HP:0000524)2.57680257
62Sandal gap (HP:0001852)2.57392326
63Loss of speech (HP:0002371)2.56531246
64Nonprogressive disorder (HP:0003680)2.54843440
65Supernumerary spleens (HP:0009799)2.53345121
66Chronic bronchitis (HP:0004469)2.53095912
67Muscle stiffness (HP:0003552)2.52276340
68Acute myeloid leukemia (HP:0004808)2.52213884
69Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.51759841
70Aplasia of the musculature (HP:0100854)2.48816092
71Atelectasis (HP:0100750)2.46215139
72Lip pit (HP:0100267)2.45960391
73Type 2 muscle fiber atrophy (HP:0003554)2.45149094
74Abnormality of the fingertips (HP:0001211)2.44500065
75Amniotic constriction ring (HP:0009775)2.44091239
76Abnormality of placental membranes (HP:0011409)2.44091239
77Fair hair (HP:0002286)2.43729525
78Skin pits (HP:0100276)2.43374822
79Anterior segment dysgenesis (HP:0007700)2.42987175
80Abnormality of chromosome stability (HP:0003220)2.42660019
81Posterior subcapsular cataract (HP:0007787)2.41559690
82Abnormality of lateral ventricle (HP:0030047)2.38767201
83Malnutrition (HP:0004395)2.37660745
84Intrahepatic cholestasis (HP:0001406)2.36612735
85Dysdiadochokinesis (HP:0002075)2.34445087
86Proximal tubulopathy (HP:0000114)2.34046757
87Aplasia/Hypoplasia involving the musculature (HP:0001460)2.33537098
88Striae distensae (HP:0001065)2.33515585
89Overlapping toe (HP:0001845)2.32846719
90Muscle fiber atrophy (HP:0100295)2.32022466
91Deep venous thrombosis (HP:0002625)2.31821048
92Fetal akinesia sequence (HP:0001989)2.30580886
93Myokymia (HP:0002411)2.28923855
94Abnormality of the epiphysis of the femoral head (HP:0010574)2.28790447
95Oligodactyly (HP:0012165)2.28471753
96Carpal bone hypoplasia (HP:0001498)2.27566731
97Aplasia/Hypoplasia of the uvula (HP:0010293)2.26105788
98Generalized aminoaciduria (HP:0002909)2.25085811
99Rhabdomyosarcoma (HP:0002859)2.21929188
100Stillbirth (HP:0003826)2.19884213
101Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.19789583
102Aplasia/Hypoplasia of the tongue (HP:0010295)2.19523962
103Abnormality of the preputium (HP:0100587)2.17374065
104Anhidrosis (HP:0000970)2.16650315
105Abnormal ciliary motility (HP:0012262)2.16029202
106Sloping forehead (HP:0000340)2.13698646
107Wrist flexion contracture (HP:0001239)2.13290083
108Absent radius (HP:0003974)2.13202122
109Duodenal stenosis (HP:0100867)2.13031536
110Small intestinal stenosis (HP:0012848)2.13031536
111Congenital sensorineural hearing impairment (HP:0008527)2.12912335
112Aplasia/Hypoplasia of the sternum (HP:0006714)2.12551688
113Abnormal biliary tract physiology (HP:0012439)2.12510072
114Bile duct proliferation (HP:0001408)2.12510072
115Abnormality of the femoral head (HP:0003368)2.12239521
116Abnormality of the proximal phalanges of the hand (HP:0009834)2.12138080
117Sensory axonal neuropathy (HP:0003390)2.11939165
118Bundle branch block (HP:0011710)2.11456830
119Anosmia (HP:0000458)2.11183102
120Maternal diabetes (HP:0009800)2.10079386
121Hyperglycemia (HP:0003074)2.10000614
122Aplasia involving forearm bones (HP:0009822)2.07843414
123Absent forearm bone (HP:0003953)2.07843414
124Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.07658926
125Fibular aplasia (HP:0002990)2.07335144
126Absent hand (HP:0004050)2.05877459
127Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.05659047
128Abnormality of femoral epiphyses (HP:0006499)2.05659047
129Heterotopia (HP:0002282)2.03825822
130Thyroid carcinoma (HP:0002890)2.03390102
131Villous atrophy (HP:0011473)2.01005984
132Abnormality of small intestinal villus morphology (HP:0011472)2.01005984
133Abnormality of the phalanges of the hallux (HP:0010057)2.00988603
134Cystic hygroma (HP:0000476)2.00574922
135Hypoplastic iliac wings (HP:0002866)2.00558034
136Subcapsular cataract (HP:0000523)2.00273942
137Abnormality of the anterior chamber (HP:0000593)1.99377786
138Nephroblastoma (Wilms tumor) (HP:0002667)1.98853494
139Midline defect of the nose (HP:0004122)1.98646991
140Abnormality of the vasculature of the conjunctiva (HP:0008054)1.98585182
141Meckel diverticulum (HP:0002245)1.97874816
142Sparse lateral eyebrow (HP:0005338)1.97314775
143Abnormal lung lobation (HP:0002101)1.96750135
144Aplastic anemia (HP:0001915)1.96599252
145Abnormality of monocarboxylic acid metabolism (HP:0010996)1.95135173
146Abnormality of calcium-phosphate metabolism (HP:0100530)1.93904629
147Hypogonadotrophic hypogonadism (HP:0000044)1.90768952
148Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.90562394
149Abnormality of alanine metabolism (HP:0010916)1.90562394
150Hyperalaninemia (HP:0003348)1.90562394
151Oral leukoplakia (HP:0002745)1.89906970
152Ankle contracture (HP:0006466)1.88175273
153Embryonal renal neoplasm (HP:0011794)1.87125475
154Microglossia (HP:0000171)1.86831647
155Increased circulating renin level (HP:0000848)1.85326662
156Arachnodactyly (HP:0001166)1.85154178
157Dysmetric saccades (HP:0000641)1.85027246
158Camptodactyly of toe (HP:0001836)1.83866800
159Hydroureter (HP:0000072)1.82267406
160Abnormality of the ileum (HP:0001549)1.82144147
161Combined immunodeficiency (HP:0005387)1.80679752
162Abnormality of cochlea (HP:0000375)1.80154544
163Impulsivity (HP:0100710)1.79281522
164Abnormal respiratory motile cilium physiology (HP:0012261)1.79043358
165Rickets (HP:0002748)1.78271364
166Short thumb (HP:0009778)1.78258156
167Hip contracture (HP:0003273)1.77556072
168Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.73257144
169Abnormality of aromatic amino acid family metabolism (HP:0004338)1.73233690
170Cranial hyperostosis (HP:0004437)1.72281341

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K64.28643483
2MUSK3.83070491
3TAOK33.61896363
4EEF2K3.59313707
5ERBB43.58161758
6KSR23.56320121
7BRAF3.33649873
8MOS3.32355709
9PLK43.30833908
10TTK3.25800505
11NEK63.22151539
12MAP3K93.11444410
13LATS12.90858428
14LATS22.88795404
15CDK122.69748327
16MAP3K132.62215354
17BMPR22.56137536
18ARAF2.40326949
19MAPKAPK32.38377368
20MET2.28503366
21TAOK12.24527574
22STK38L2.21642860
23RAF12.18074818
24CDK81.86630781
25CDC71.73057043
26MELK1.69385212
27PRKCI1.65931917
28PRKD31.65061399
29EIF2AK31.55008220
30STK101.52968558
31MAPKAPK51.48360325
32KSR11.48256713
33PAK61.46311934
34CHEK21.45352413
35TRIM281.38724366
36NEK21.34062646
37MAPK131.32917159
38CDK91.31750535
39STK31.26905653
40TNIK1.26385596
41PLK11.19882314
42MAP3K41.05246935
43MST41.03183248
44DYRK21.02843705
45MAP3K81.00307447
46PTK20.99758396
47TRPM70.97372175
48PIM10.91689077
49BUB10.91144804
50PRKD20.89202297
51CDK190.86769909
52ZAK0.82615547
53TNK20.82418388
54MAP2K70.77536564
55RPS6KB20.74901550
56WNK10.74686085
57AURKA0.73647094
58DMPK0.72366275
59MARK30.71793287
60TIE10.67576755
61AURKB0.67221281
62PRKAA20.65285131
63ACVR1B0.64590481
64RET0.62092597
65STK390.60408469
66TGFBR10.59583818
67CSNK1G10.57425493
68BRSK20.57399973
69MARK20.57070403
70ABL20.56523608
71STK380.56099417
72NLK0.55157016
73PRKAA10.54474043
74NTRK30.53201402
75PRKG10.52565656
76TYRO30.51609572
77MTOR0.51245783
78NTRK20.50008777
79MAPK110.47835802
80LRRK20.47209586
81PINK10.46246915
82MAP2K40.45813414
83PLK30.45168898
84PRKCZ0.44825024
85STK240.44016404
86MAP3K50.41601553
87PKN10.39536290
88CSNK1G20.38385602
89MAP3K10.38112860
90CSNK1E0.38091055
91CSNK1G30.37902295
92NEK90.37637381
93SGK20.37367419
94EIF2AK10.35270380
95CAMK1D0.34105367
96CHEK10.33403786
97CAMK2A0.32970792
98CDK50.32385094
99PDK10.32017543
100ATM0.30913249
101SGK2230.30229539
102SGK4940.30229539
103PRKACB0.28806789
104MAP2K10.28719238
105CHUK0.28556720
106BRSK10.28468714
107CDK30.27078716
108SRPK10.26295601
109GSK3B0.24643578
110PRKACA0.24442294
111CDK70.24009776
112NUAK10.23560859
113MAPK10.23068223
114OXSR10.22551511
115CDK10.22219949
116BMPR1B0.22119098
117EPHA40.21345210
118AKT20.20324978
119PBK0.20195394
120CSNK1A1L0.19972374
121TLK10.19436446
122BRD40.19276886
123CDK40.18576606
124VRK10.18076844
125PAK10.17478818
126ABL10.17226049
127MAPK100.16928307
128FGR0.16629899
129EPHA30.15965654
130CDK20.15784572
131PLK20.15746027
132PDPK10.15282184
133LMTK20.13414832
134KIT0.13349079
135CSNK1D0.12559892
136EGFR0.12420389
137CDK150.12163250
138CDK180.10574724
139AKT10.09776849
140RPS6KA40.09606638
141CAMK1G0.09535472
142ATR0.08402961
143CDK11A0.06896185
144JAK20.06737407
145STK110.06475196

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049134.53321412
2Cell cycle_Homo sapiens_hsa041104.13349863
3RNA degradation_Homo sapiens_hsa030183.81255071
4Basal transcription factors_Homo sapiens_hsa030223.40452923
5Vitamin B6 metabolism_Homo sapiens_hsa007503.23971756
6Caffeine metabolism_Homo sapiens_hsa002323.13762159
7Circadian rhythm_Homo sapiens_hsa047102.87992404
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.81068918
9Linoleic acid metabolism_Homo sapiens_hsa005912.72699226
10Oocyte meiosis_Homo sapiens_hsa041142.46384615
11Ether lipid metabolism_Homo sapiens_hsa005652.39636045
12Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.35881690
13Pancreatic cancer_Homo sapiens_hsa052122.32603121
14Homologous recombination_Homo sapiens_hsa034402.24764039
15Fanconi anemia pathway_Homo sapiens_hsa034602.04922673
16GnRH signaling pathway_Homo sapiens_hsa049121.97414982
17Olfactory transduction_Homo sapiens_hsa047401.96859068
18Base excision repair_Homo sapiens_hsa034101.91895735
19RNA transport_Homo sapiens_hsa030131.74142749
20TGF-beta signaling pathway_Homo sapiens_hsa043501.72353060
21Dorso-ventral axis formation_Homo sapiens_hsa043201.70658006
22p53 signaling pathway_Homo sapiens_hsa041151.64605268
23Non-homologous end-joining_Homo sapiens_hsa034501.60884221
24RNA polymerase_Homo sapiens_hsa030201.56008794
25Colorectal cancer_Homo sapiens_hsa052101.44562100
26Choline metabolism in cancer_Homo sapiens_hsa052311.37871212
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.35428131
28DNA replication_Homo sapiens_hsa030301.32902164
29Prolactin signaling pathway_Homo sapiens_hsa049171.32456929
30Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.31084123
31Phototransduction_Homo sapiens_hsa047441.30946180
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.26648870
33Mismatch repair_Homo sapiens_hsa034301.25998293
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.25939909
35MicroRNAs in cancer_Homo sapiens_hsa052061.24141785
36VEGF signaling pathway_Homo sapiens_hsa043701.22559542
37Nucleotide excision repair_Homo sapiens_hsa034201.21587827
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.21403790
39Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.16093827
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.16001259
41Glycerophospholipid metabolism_Homo sapiens_hsa005641.12485919
42Long-term depression_Homo sapiens_hsa047301.11343034
43ABC transporters_Homo sapiens_hsa020101.10183485
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.06952941
45Renal cell carcinoma_Homo sapiens_hsa052111.01056414
46Nicotine addiction_Homo sapiens_hsa050330.90567035
47Hippo signaling pathway_Homo sapiens_hsa043900.90401471
48mRNA surveillance pathway_Homo sapiens_hsa030150.89707276
49Other glycan degradation_Homo sapiens_hsa005110.89393288
50Bile secretion_Homo sapiens_hsa049760.88975089
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.88825689
52Morphine addiction_Homo sapiens_hsa050320.81165387
53Ras signaling pathway_Homo sapiens_hsa040140.79923702
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.76808173
55Adherens junction_Homo sapiens_hsa045200.76166350
56FoxO signaling pathway_Homo sapiens_hsa040680.75984661
57Endometrial cancer_Homo sapiens_hsa052130.75485347
58GABAergic synapse_Homo sapiens_hsa047270.74903655
59mTOR signaling pathway_Homo sapiens_hsa041500.74172517
60Bladder cancer_Homo sapiens_hsa052190.73610733
61Taste transduction_Homo sapiens_hsa047420.72274342
62Arachidonic acid metabolism_Homo sapiens_hsa005900.72236534
63Fatty acid elongation_Homo sapiens_hsa000620.71851983
64Inositol phosphate metabolism_Homo sapiens_hsa005620.71496742
65Non-small cell lung cancer_Homo sapiens_hsa052230.65627406
66Notch signaling pathway_Homo sapiens_hsa043300.65326486
67Purine metabolism_Homo sapiens_hsa002300.63321388
68Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62943142
69Pyrimidine metabolism_Homo sapiens_hsa002400.61154881
70Synaptic vesicle cycle_Homo sapiens_hsa047210.60352348
71Thyroid cancer_Homo sapiens_hsa052160.60092729
72Chronic myeloid leukemia_Homo sapiens_hsa052200.59152768
73Serotonergic synapse_Homo sapiens_hsa047260.59023038
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58752031
75Small cell lung cancer_Homo sapiens_hsa052220.58511266
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58433735
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58258510
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53445271
79Folate biosynthesis_Homo sapiens_hsa007900.53016537
80Viral carcinogenesis_Homo sapiens_hsa052030.52804012
81Hepatitis B_Homo sapiens_hsa051610.50381454
82Estrogen signaling pathway_Homo sapiens_hsa049150.50043509
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49361977
84HTLV-I infection_Homo sapiens_hsa051660.47662975
85Glycosaminoglycan degradation_Homo sapiens_hsa005310.46582337
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46435778
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45274986
88Glutamatergic synapse_Homo sapiens_hsa047240.42754610
89Vitamin digestion and absorption_Homo sapiens_hsa049770.41571218
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41494232
91MAPK signaling pathway_Homo sapiens_hsa040100.41457632
92Aldosterone synthesis and secretion_Homo sapiens_hsa049250.40039812
93ErbB signaling pathway_Homo sapiens_hsa040120.38016671
94Glioma_Homo sapiens_hsa052140.34618452
95Melanoma_Homo sapiens_hsa052180.34390641
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.33807202
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33595358
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33225793
99Prostate cancer_Homo sapiens_hsa052150.32598390
100Arginine and proline metabolism_Homo sapiens_hsa003300.29943996
101Shigellosis_Homo sapiens_hsa051310.28991059
102Pyruvate metabolism_Homo sapiens_hsa006200.27396203
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.24915035
104Arginine biosynthesis_Homo sapiens_hsa002200.24640204
105Regulation of autophagy_Homo sapiens_hsa041400.24139749
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.23277537
107Gap junction_Homo sapiens_hsa045400.22140318
108cGMP-PKG signaling pathway_Homo sapiens_hsa040220.21451032
109Protein digestion and absorption_Homo sapiens_hsa049740.21180702
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.20786428
111Wnt signaling pathway_Homo sapiens_hsa043100.20456835
112Oxytocin signaling pathway_Homo sapiens_hsa049210.20285180
113Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.19126522
114Sphingolipid metabolism_Homo sapiens_hsa006000.19086750
115Herpes simplex infection_Homo sapiens_hsa051680.18454342
116Pathways in cancer_Homo sapiens_hsa052000.18056897
117Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.17960100
118cAMP signaling pathway_Homo sapiens_hsa040240.17953161
119TNF signaling pathway_Homo sapiens_hsa046680.17542718
120Phagosome_Homo sapiens_hsa041450.16591861
121Epstein-Barr virus infection_Homo sapiens_hsa051690.16260852
122Hedgehog signaling pathway_Homo sapiens_hsa043400.15399909
123Histidine metabolism_Homo sapiens_hsa003400.14165411
124Cholinergic synapse_Homo sapiens_hsa047250.12239334
125Lysine degradation_Homo sapiens_hsa003100.11773640
126Huntingtons disease_Homo sapiens_hsa050160.11472787
127Long-term potentiation_Homo sapiens_hsa047200.10138958
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.09747944
129Tight junction_Homo sapiens_hsa045300.09620084
130Propanoate metabolism_Homo sapiens_hsa006400.07130519
131Amoebiasis_Homo sapiens_hsa051460.06683909
132HIF-1 signaling pathway_Homo sapiens_hsa040660.06453785
133Spliceosome_Homo sapiens_hsa030400.06398709
134Neurotrophin signaling pathway_Homo sapiens_hsa047220.06262958
135PI3K-Akt signaling pathway_Homo sapiens_hsa041510.05965129
136Circadian entrainment_Homo sapiens_hsa047130.05494246
137Influenza A_Homo sapiens_hsa051640.05439377

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