KNSTRN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)6.55143184
2protein localization to chromosome, centromeric region (GO:0071459)6.01323433
3mitotic metaphase plate congression (GO:0007080)5.74732004
4* mitotic sister chromatid segregation (GO:0000070)5.61939589
5mitotic chromosome condensation (GO:0007076)5.43964172
6* sister chromatid segregation (GO:0000819)5.12132438
7metaphase plate congression (GO:0051310)5.00599385
8kinetochore organization (GO:0051383)4.80361442
9attachment of spindle microtubules to kinetochore (GO:0008608)4.73352306
10CENP-A containing nucleosome assembly (GO:0034080)4.69633956
11establishment of chromosome localization (GO:0051303)4.66801669
12chromatin remodeling at centromere (GO:0031055)4.62369531
13DNA replication checkpoint (GO:0000076)4.58481770
14DNA replication-dependent nucleosome assembly (GO:0006335)4.46553832
15DNA replication-dependent nucleosome organization (GO:0034723)4.46553832
16regulation of spindle organization (GO:0090224)4.44803610
17kinetochore assembly (GO:0051382)4.42929610
18DNA ligation (GO:0006266)4.34246186
19DNA replication-independent nucleosome organization (GO:0034724)4.31611853
20DNA replication-independent nucleosome assembly (GO:0006336)4.31611853
21mitotic nuclear envelope disassembly (GO:0007077)4.28913417
22establishment of integrated proviral latency (GO:0075713)4.26410332
23* regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.25329068
24meiotic chromosome segregation (GO:0045132)4.20379912
25protein localization to chromosome (GO:0034502)4.19768675
26proteasome assembly (GO:0043248)4.17198171
27DNA unwinding involved in DNA replication (GO:0006268)4.14995722
28nuclear pore complex assembly (GO:0051292)4.07602431
29histone exchange (GO:0043486)4.04781465
30spindle checkpoint (GO:0031577)4.00660294
31DNA replication initiation (GO:0006270)4.00519987
32nuclear envelope disassembly (GO:0051081)3.97974590
33membrane disassembly (GO:0030397)3.97974590
34nuclear pore organization (GO:0006999)3.96823937
35regulation of mitotic spindle organization (GO:0060236)3.95894644
36anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.95279137
37* chromosome segregation (GO:0007059)3.92184371
38regulation of telomere maintenance via telomerase (GO:0032210)3.90824448
39chromosome condensation (GO:0030261)3.90410443
40DNA strand elongation involved in DNA replication (GO:0006271)3.83626221
41chromatin assembly or disassembly (GO:0006333)3.78653714
42regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.77962201
43* regulation of chromosome segregation (GO:0051983)3.77492699
44spindle assembly checkpoint (GO:0071173)3.77334712
45mitotic sister chromatid cohesion (GO:0007064)3.74109374
46negative regulation of chromosome segregation (GO:0051985)3.66633706
47negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.65323633
48negative regulation of mitotic sister chromatid separation (GO:2000816)3.64798010
49negative regulation of mitotic sister chromatid segregation (GO:0033048)3.64798010
50negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.64798010
51negative regulation of sister chromatid segregation (GO:0033046)3.64798010
52positive regulation of DNA-dependent DNA replication (GO:2000105)3.63919667
53DNA strand elongation (GO:0022616)3.63679789
54positive regulation of chromosome segregation (GO:0051984)3.62388942
55telomere maintenance via semi-conservative replication (GO:0032201)3.60232259
56mitotic spindle assembly checkpoint (GO:0007094)3.58743821
57negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.57378145
58mitotic spindle checkpoint (GO:0071174)3.56248420
59regulation of mitotic metaphase/anaphase transition (GO:0030071)3.54773576
60positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.53076062
61mitotic recombination (GO:0006312)3.52453162
62ribosome assembly (GO:0042255)3.51040357
63microtubule depolymerization (GO:0007019)3.49414304
64regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.49267872
65negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.46747088
66regulation of centriole replication (GO:0046599)3.45809899
67regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.45739463
68regulation of nuclear cell cycle DNA replication (GO:0033262)3.45453560
69regulation of sister chromatid cohesion (GO:0007063)3.44029882
70DNA packaging (GO:0006323)3.44015811
71regulation of exit from mitosis (GO:0007096)3.41985345
72telomere maintenance via recombination (GO:0000722)3.40994202
73regulation of sister chromatid segregation (GO:0033045)3.40257093
74regulation of mitotic sister chromatid separation (GO:0010965)3.40257093
75regulation of mitotic sister chromatid segregation (GO:0033047)3.40257093
76DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.37223093
77ventricular cardiac muscle cell development (GO:0055015)3.35406923
78negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.34125648
79negative regulation of ligase activity (GO:0051352)3.34125648
80regulation of double-strand break repair via homologous recombination (GO:0010569)3.32463292
81positive regulation of mitotic sister chromatid separation (GO:1901970)3.32086177
82positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.32086177
83positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.32086177
84DNA topological change (GO:0006265)3.31225034
85ATP-dependent chromatin remodeling (GO:0043044)3.31207497
86negative regulation of cell cycle G2/M phase transition (GO:1902750)3.28976245
87establishment of viral latency (GO:0019043)3.26814182
88replication fork processing (GO:0031297)3.26398704
89protein K6-linked ubiquitination (GO:0085020)3.25775510
90regulation of mitotic spindle checkpoint (GO:1903504)3.25004014
91regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.25004014
92DNA damage response, signal transduction resulting in transcription (GO:0042772)3.24993801
93regulation of centrosome cycle (GO:0046605)3.20909641
94heterochromatin organization (GO:0070828)3.18602276
95DNA duplex unwinding (GO:0032508)3.17600972
96DNA geometric change (GO:0032392)3.16439226
97DNA conformation change (GO:0071103)3.13790131
98positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.09294587
99nuclear envelope organization (GO:0006998)3.09157568
100mitotic G2/M transition checkpoint (GO:0044818)3.08792828
101non-recombinational repair (GO:0000726)3.08011975
102double-strand break repair via nonhomologous end joining (GO:0006303)3.08011975
103rRNA modification (GO:0000154)3.06828844
104regulation of double-strand break repair (GO:2000779)3.06000967
105DNA double-strand break processing (GO:0000729)3.05991957
106pore complex assembly (GO:0046931)3.05958647
107mitotic cell cycle (GO:0000278)3.00696686
108telomere maintenance via telomere lengthening (GO:0010833)2.99992906
109folic acid-containing compound biosynthetic process (GO:0009396)2.99592726
110establishment of protein localization to mitochondrial membrane (GO:0090151)2.98488796
111regulation of ubiquitin-protein transferase activity (GO:0051438)2.98448853
112regulation of mitochondrial translation (GO:0070129)2.98370084
113regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.97334464
114regulation of spindle checkpoint (GO:0090231)2.96844346
115positive regulation of ligase activity (GO:0051351)2.95833486
116nucleotide-excision repair, DNA gap filling (GO:0006297)2.95487630
117negative regulation of telomerase activity (GO:0051974)2.94760655
118spindle assembly involved in mitosis (GO:0090307)2.93081244
119resolution of meiotic recombination intermediates (GO:0000712)2.92403583
120microtubule polymerization or depolymerization (GO:0031109)2.91872366
121rRNA methylation (GO:0031167)2.90936325
122negative regulation of mitosis (GO:0045839)2.90668796
123maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.90487403
124negative regulation of telomere maintenance (GO:0032205)2.90362208
125chaperone-mediated protein transport (GO:0072321)2.90245046
126chromatin assembly (GO:0031497)2.89926453
127mitotic nuclear division (GO:0007067)2.88543311
128maturation of 5.8S rRNA (GO:0000460)2.87677528
129spindle assembly (GO:0051225)2.80863646
130* chromosome organization (GO:0051276)2.76903158

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.51101322
2FOXM1_23109430_ChIP-Seq_U2OS_Human7.23782742
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.76224113
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.61582699
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.46699191
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.12243783
7AR_21909140_ChIP-Seq_LNCAP_Human2.86675573
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.78289689
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.68121264
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.48663947
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.42143132
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.29923103
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.24698216
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.24561416
15E2F1_21310950_ChIP-Seq_MCF-7_Human2.17543553
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.14601939
17MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.14093888
18TP63_19390658_ChIP-ChIP_HaCaT_Human2.13619036
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.07640760
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.02978476
21XRN2_22483619_ChIP-Seq_HELA_Human1.97425584
22KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.97374268
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95357092
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.93806992
25EGR1_19374776_ChIP-ChIP_THP-1_Human1.90855525
26ETS1_20019798_ChIP-Seq_JURKAT_Human1.87727032
27NANOG_18555785_ChIP-Seq_MESCs_Mouse1.80944807
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.77591594
29MYCN_18555785_ChIP-Seq_MESCs_Mouse1.73738465
30FOXP3_21729870_ChIP-Seq_TREG_Human1.65643319
31VDR_23849224_ChIP-Seq_CD4+_Human1.65143620
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.65027572
33MYC_22102868_ChIP-Seq_BL_Human1.58547292
34E2F1_18555785_ChIP-Seq_MESCs_Mouse1.58378279
35TTF2_22483619_ChIP-Seq_HELA_Human1.55950958
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54984505
37DCP1A_22483619_ChIP-Seq_HELA_Human1.52747986
38GABP_19822575_ChIP-Seq_HepG2_Human1.49136922
39KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.44810379
40KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.44810379
41KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.44810379
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.42327175
43KDM5A_27292631_Chip-Seq_BREAST_Human1.41484090
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36603118
45* CIITA_25753668_ChIP-Seq_RAJI_Human1.35029251
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.34340126
47POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.34250056
48ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33821252
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32009288
50SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.31648287
51E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.30106727
52RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30027889
53KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25597030
54ELK1_19687146_ChIP-ChIP_HELA_Human1.25455969
55BP1_19119308_ChIP-ChIP_Hs578T_Human1.24178305
56SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.23799758
57NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.22598111
58HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22120315
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22068898
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21895276
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21205421
62EWS_26573619_Chip-Seq_HEK293_Human1.18640033
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18444553
64SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16110858
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15423215
66SOX2_16153702_ChIP-ChIP_HESCs_Human1.13342627
67THAP11_20581084_ChIP-Seq_MESCs_Mouse1.11615925
68STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11254383
69ELF1_17652178_ChIP-ChIP_JURKAT_Human1.10383155
70POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09265970
71YY1_21170310_ChIP-Seq_MESCs_Mouse1.08915347
72ZNF274_21170338_ChIP-Seq_K562_Hela1.08451619
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.08091229
74DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07684160
75NANOG_21062744_ChIP-ChIP_HESCs_Human1.06749832
76FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05997411
77CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05811491
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.03960365
79TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02358187
80PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01728315
81TCF3_18692474_ChIP-Seq_MEFs_Mouse1.01582036
82KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99815514
83SOX17_20123909_ChIP-Seq_XEN_Mouse0.98138812
84MYC_18940864_ChIP-ChIP_HL60_Human0.97482195
85TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97249427
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95422524
87SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95341021
88TCF3_18692474_ChIP-Seq_MESCs_Mouse0.94715810
89CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90350635
90FUS_26573619_Chip-Seq_HEK293_Human0.89162410
91ERG_20887958_ChIP-Seq_HPC-7_Mouse0.89026081
92KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.87139248
93ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84970550
94TFEB_21752829_ChIP-Seq_HELA_Human0.84918890
95SALL1_21062744_ChIP-ChIP_HESCs_Human0.84761493
96NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.83085827
97SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.82615602
98NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.80956461
99VDR_21846776_ChIP-Seq_THP-1_Human0.80952864
100HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.80316086
101RBPJ_22232070_ChIP-Seq_NCS_Mouse0.79461546
102TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.78847008
103FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.78270877
104SRF_21415370_ChIP-Seq_HL-1_Mouse0.77919231
105NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.76382584
106CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.76350613
107NANOG_16153702_ChIP-ChIP_HESCs_Human0.75453882
108SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.75188106
109ELK1_22589737_ChIP-Seq_MCF10A_Human0.74303318
110CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.74241468
111FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.73838543
112PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.73621463
113DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.73421617
114CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.72752147
115E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.72473991
116IRF1_19129219_ChIP-ChIP_H3396_Human0.71598089
117VDR_22108803_ChIP-Seq_LS180_Human0.70283914
118BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.66855818
119SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.65020522
120TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.60264033
121CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.60218156
122ESR1_15608294_ChIP-ChIP_MCF-7_Human0.60004381
123GATA1_26923725_Chip-Seq_HPCs_Mouse0.57090981

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.96460581
2MP0003111_abnormal_nucleus_morphology4.43753502
3MP0010094_abnormal_chromosome_stability4.29439196
4MP0004957_abnormal_blastocyst_morpholog4.28136944
5MP0003077_abnormal_cell_cycle3.96918888
6MP0008057_abnormal_DNA_replication3.30424469
7MP0003123_paternal_imprinting2.81068480
8MP0008007_abnormal_cellular_replicative2.68139372
9MP0008932_abnormal_embryonic_tissue2.45506074
10MP0008058_abnormal_DNA_repair2.32435494
11MP0000350_abnormal_cell_proliferation2.23597449
12MP0001730_embryonic_growth_arrest2.12851888
13MP0003121_genomic_imprinting2.04036849
14MP0002653_abnormal_ependyma_morphology1.99720330
15MP0010030_abnormal_orbit_morphology1.99689197
16MP0006292_abnormal_olfactory_placode1.99633331
17MP0005380_embryogenesis_phenotype1.97507946
18MP0001672_abnormal_embryogenesis/_devel1.97507946
19MP0002396_abnormal_hematopoietic_system1.92814062
20MP0009697_abnormal_copulation1.91909949
21MP0001697_abnormal_embryo_size1.79249643
22MP0002085_abnormal_embryonic_tissue1.77717418
23MP0003984_embryonic_growth_retardation1.77651829
24MP0002088_abnormal_embryonic_growth/wei1.74084830
25MP0010307_abnormal_tumor_latency1.72673351
26MP0008877_abnormal_DNA_methylation1.70788077
27MP0003890_abnormal_embryonic-extraembry1.70407139
28MP0000490_abnormal_crypts_of1.66097823
29MP0004264_abnormal_extraembryonic_tissu1.61576016
30MP0003718_maternal_effect1.61316708
31MP0010352_gastrointestinal_tract_polyps1.60348886
32MP0003941_abnormal_skin_development1.59261786
33MP0002084_abnormal_developmental_patter1.55822959
34MP0003806_abnormal_nucleotide_metabolis1.50067457
35MP0002086_abnormal_extraembryonic_tissu1.49863475
36MP0003136_yellow_coat_color1.49831019
37MP0006035_abnormal_mitochondrial_morpho1.49053279
38MP0002080_prenatal_lethality1.48610981
39MP0002102_abnormal_ear_morphology1.48517250
40MP0003786_premature_aging1.42356345
41MP0001529_abnormal_vocalization1.42302660
42MP0000313_abnormal_cell_death1.39798374
43MP0003315_abnormal_perineum_morphology1.37984880
44MP0002234_abnormal_pharynx_morphology1.36221205
45MP0002210_abnormal_sex_determination1.36178986
46MP0001929_abnormal_gametogenesis1.32384226
47MP0003705_abnormal_hypodermis_morpholog1.32375290
48MP0002019_abnormal_tumor_incidence1.32017344
49MP0003950_abnormal_plasma_membrane1.29057071
50MP0004197_abnormal_fetal_growth/weight/1.27564219
51MP0003186_abnormal_redox_activity1.25077899
52MP0004808_abnormal_hematopoietic_stem1.24494877
53MP0003937_abnormal_limbs/digits/tail_de1.22933849
54MP0001145_abnormal_male_reproductive1.22334192
55MP0005076_abnormal_cell_differentiation1.20725202
56MP0000372_irregular_coat_pigmentation1.19423042
57MP0001293_anophthalmia1.17913080
58MP0002697_abnormal_eye_size1.14072009
59MP0000358_abnormal_cell_content/1.13824011
60MP0000653_abnormal_sex_gland1.12006382
61MP0001119_abnormal_female_reproductive1.11963206
62MP0006036_abnormal_mitochondrial_physio1.09070619
63MP0005395_other_phenotype1.08569143
64MP0000537_abnormal_urethra_morphology1.06545205
65MP0000647_abnormal_sebaceous_gland1.05611602
66MP0001849_ear_inflammation0.97633286
67MP0002932_abnormal_joint_morphology0.95412256
68MP0003787_abnormal_imprinting0.95197479
69MP0000432_abnormal_head_morphology0.94795736
70MP0003011_delayed_dark_adaptation0.94232558
71MP0005257_abnormal_intraocular_pressure0.93745037
72MP0002249_abnormal_larynx_morphology0.93391916
73MP0005394_taste/olfaction_phenotype0.91532279
74MP0005499_abnormal_olfactory_system0.91532279
75MP0003935_abnormal_craniofacial_develop0.88036363
76MP0003755_abnormal_palate_morphology0.87610315
77MP0002751_abnormal_autonomic_nervous0.86977831
78MP0003567_abnormal_fetal_cardiomyocyte0.86937490
79MP0003938_abnormal_ear_development0.85783655
80MP0005397_hematopoietic_system_phenotyp0.85231811
81MP0001545_abnormal_hematopoietic_system0.85231811
82MP0002092_abnormal_eye_morphology0.85071750
83MP0000703_abnormal_thymus_morphology0.84066830
84MP0000428_abnormal_craniofacial_morphol0.83835505
85MP0000678_abnormal_parathyroid_gland0.83156328
86MP0000858_altered_metastatic_potential0.82621576
87MP0002160_abnormal_reproductive_system0.81983771
88MP0002111_abnormal_tail_morphology0.81598955
89MP0008789_abnormal_olfactory_epithelium0.79481829
90MP0000049_abnormal_middle_ear0.79300933
91MP0003119_abnormal_digestive_system0.79212959
92MP0001915_intracranial_hemorrhage0.78665707
93MP0003861_abnormal_nervous_system0.78523573
94MP0009053_abnormal_anal_canal0.78352454
95MP0003699_abnormal_female_reproductive0.78059297
96MP0006072_abnormal_retinal_apoptosis0.77569933
97MP0002114_abnormal_axial_skeleton0.76886208
98MP0001346_abnormal_lacrimal_gland0.75817289
99MP0005410_abnormal_fertilization0.75363644
100MP0005023_abnormal_wound_healing0.74660626
101MP0005075_abnormal_melanosome_morpholog0.74404541
102MP0005384_cellular_phenotype0.74243419
103MP0001286_abnormal_eye_development0.73629841
104MP0000631_abnormal_neuroendocrine_gland0.72758430
105MP0009333_abnormal_splenocyte_physiolog0.72661753
106MP0005621_abnormal_cell_physiology0.72481464
107MP0002925_abnormal_cardiovascular_devel0.72370770
108MP0002233_abnormal_nose_morphology0.72061750
109MP0002132_abnormal_respiratory_system0.71949524
110MP0002163_abnormal_gland_morphology0.71638729
111MP0003698_abnormal_male_reproductive0.71386265
112MP0002722_abnormal_immune_system0.70590671
113MP0009379_abnormal_foot_pigmentation0.70553649
114MP0009672_abnormal_birth_weight0.70183518
115MP0008995_early_reproductive_senescence0.70028758
116MP0002877_abnormal_melanocyte_morpholog0.69864399
117MP0002398_abnormal_bone_marrow0.69852344
118MP0009703_decreased_birth_body0.69507151
119MP0002116_abnormal_craniofacial_bone0.69408666
120MP0002161_abnormal_fertility/fecundity0.68692696
121MP0000689_abnormal_spleen_morphology0.66970807
122MP0003943_abnormal_hepatobiliary_system0.66398011
123MP0004233_abnormal_muscle_weight0.65809056
124MP0001188_hyperpigmentation0.65350207
125MP0002938_white_spotting0.64748216
126MP0002282_abnormal_trachea_morphology0.63477610
127MP0005391_vision/eye_phenotype0.62809973
128MP0005408_hypopigmentation0.62767565
129MP0003122_maternal_imprinting0.62060966
130MP0000762_abnormal_tongue_morphology0.62047969
131MP0002095_abnormal_skin_pigmentation0.61587702
132MP0000733_abnormal_muscle_development0.60711843
133MP0002127_abnormal_cardiovascular_syste0.60649412
134MP0005623_abnormal_meninges_morphology0.59631428
135MP0009250_abnormal_appendicular_skeleto0.59051902
136MP0000566_synostosis0.58783591
137MP0005389_reproductive_system_phenotype0.58668139

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.26083959
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.24164453
3Meckel diverticulum (HP:0002245)3.76278480
4Birth length less than 3rd percentile (HP:0003561)3.62295086
5Aplasia/Hypoplasia of the uvula (HP:0010293)3.55793140
6Abnormality of the ileum (HP:0001549)3.54744184
7Abnormality of the preputium (HP:0100587)3.41548409
8Abnormality of chromosome stability (HP:0003220)3.41183061
9Patellar aplasia (HP:0006443)3.34325883
10Nephroblastoma (Wilms tumor) (HP:0002667)3.32549359
11Abnormal lung lobation (HP:0002101)3.31455664
12Small intestinal stenosis (HP:0012848)3.30016812
13Duodenal stenosis (HP:0100867)3.30016812
14Breast hypoplasia (HP:0003187)3.26062490
15Aplasia/Hypoplasia of the patella (HP:0006498)3.12038011
16Embryonal renal neoplasm (HP:0011794)3.09470661
17Impulsivity (HP:0100710)3.08332135
18Myelodysplasia (HP:0002863)3.02109766
19Rhabdomyosarcoma (HP:0002859)3.00682456
20Rib fusion (HP:0000902)2.90097025
21Ependymoma (HP:0002888)2.88961349
22Bilateral microphthalmos (HP:0007633)2.87970946
23Aplastic anemia (HP:0001915)2.77753330
24Sloping forehead (HP:0000340)2.77562375
25Increased nuchal translucency (HP:0010880)2.76285082
26Medulloblastoma (HP:0002885)2.72843607
27Acute necrotizing encephalopathy (HP:0006965)2.68810344
28Multiple enchondromatosis (HP:0005701)2.68457861
29Abnormality of the duodenum (HP:0002246)2.67420445
30Cortical dysplasia (HP:0002539)2.63669732
31Acute encephalopathy (HP:0006846)2.59924811
32Volvulus (HP:0002580)2.57902386
33Neoplasm of striated muscle (HP:0009728)2.57278754
34Selective tooth agenesis (HP:0001592)2.56581824
35Reticulocytopenia (HP:0001896)2.55905340
36Supernumerary spleens (HP:0009799)2.55850621
37Aplasia/Hypoplasia of the sternum (HP:0006714)2.48055194
38Carpal bone hypoplasia (HP:0001498)2.47884963
39Abnormal mitochondria in muscle tissue (HP:0008316)2.46376785
40Atresia of the external auditory canal (HP:0000413)2.44390299
41Ectopic kidney (HP:0000086)2.44000174
42Oral leukoplakia (HP:0002745)2.43334079
43Hypochromic microcytic anemia (HP:0004840)2.41644990
44Abnormality of chromosome segregation (HP:0002916)2.39680023
45Increased CSF lactate (HP:0002490)2.39212008
46Shawl scrotum (HP:0000049)2.38367529
47Abnormality of the carotid arteries (HP:0005344)2.37472710
48Abnormality of glycolysis (HP:0004366)2.37275569
49Absent radius (HP:0003974)2.35474891
50Absent septum pellucidum (HP:0001331)2.31003826
51Bone marrow hypocellularity (HP:0005528)2.30794759
52Increased serum pyruvate (HP:0003542)2.29575250
53Microretrognathia (HP:0000308)2.27876045
54Cafe-au-lait spot (HP:0000957)2.27065678
55Facial hemangioma (HP:0000329)2.25746973
56Abnormality of the septum pellucidum (HP:0007375)2.25741533
57Mitochondrial inheritance (HP:0001427)2.25456329
58Triphalangeal thumb (HP:0001199)2.25109031
59Increased hepatocellular lipid droplets (HP:0006565)2.23035958
60Tracheoesophageal fistula (HP:0002575)2.21825555
61Septo-optic dysplasia (HP:0100842)2.18707006
62Secondary amenorrhea (HP:0000869)2.18486372
63Aplasia involving forearm bones (HP:0009822)2.18425091
64Absent forearm bone (HP:0003953)2.18425091
65Abnormality of the anterior horn cell (HP:0006802)2.17035204
66Degeneration of anterior horn cells (HP:0002398)2.17035204
67Pendular nystagmus (HP:0012043)2.16180747
68Increased serum lactate (HP:0002151)2.15193113
69Microvesicular hepatic steatosis (HP:0001414)2.14796684
70Premature ovarian failure (HP:0008209)2.13385806
71Trismus (HP:0000211)2.12831965
72Abnormality of the labia minora (HP:0012880)2.12608722
73Hypoplastic pelvis (HP:0008839)2.12560763
74Aplasia/Hypoplasia of the sacrum (HP:0008517)2.11611016
75Clubbing of toes (HP:0100760)2.11457071
76Facial cleft (HP:0002006)2.11160402
77Progressive macrocephaly (HP:0004481)2.10999472
78Short 4th metacarpal (HP:0010044)2.10161716
79Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.10161716
80Reduced antithrombin III activity (HP:0001976)2.09898346
81Abnormality of alanine metabolism (HP:0010916)2.09521139
82Hyperalaninemia (HP:0003348)2.09521139
83Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.09521139
84Lipid accumulation in hepatocytes (HP:0006561)2.06556661
85Type I transferrin isoform profile (HP:0003642)2.03668468
86Aplasia/hypoplasia of the humerus (HP:0006507)2.02711983
87Colon cancer (HP:0003003)2.01517556
88Cerebral edema (HP:0002181)2.01445518
89Renal duplication (HP:0000075)1.99343562
90Abnormality of the phalanges of the hallux (HP:0010057)1.98682212
91Short middle phalanx of the 5th finger (HP:0004220)1.97184568
92Abnormality of the astrocytes (HP:0100707)1.95576516
93Astrocytoma (HP:0009592)1.95576516
94Hepatocellular necrosis (HP:0001404)1.93966099
95Abnormality of the pons (HP:0007361)1.92692051
96Abnormality of methionine metabolism (HP:0010901)1.91955678
97Hypoplasia of the pons (HP:0012110)1.88849424
98Flat capital femoral epiphysis (HP:0003370)1.88604513
99Duplicated collecting system (HP:0000081)1.87372138
100Abdominal situs inversus (HP:0003363)1.85456290
101Abnormality of abdominal situs (HP:0011620)1.85456290
102Choanal atresia (HP:0000453)1.83650197
103Preauricular skin tag (HP:0000384)1.83473866
104Cleft eyelid (HP:0000625)1.83384686
105Bifid tongue (HP:0010297)1.83300476
106Deviation of the thumb (HP:0009603)1.83024250
107Proximal placement of thumb (HP:0009623)1.82600891
108Rough bone trabeculation (HP:0100670)1.82038545
109Horseshoe kidney (HP:0000085)1.79524570
110Short 5th finger (HP:0009237)1.78821870
111Short thumb (HP:0009778)1.78586533
112Pancytopenia (HP:0001876)1.78523021
113Hypoplasia of the capital femoral epiphysis (HP:0003090)1.77507121
114Absent thumb (HP:0009777)1.77010835
115Prominent nose (HP:0000448)1.76223563
116Arteriovenous malformation (HP:0100026)1.75723629
117Neoplasm of the pancreas (HP:0002894)1.74681360
118High pitched voice (HP:0001620)1.74578983
119Preaxial hand polydactyly (HP:0001177)1.74035691
120Short humerus (HP:0005792)1.73407121
121Fused cervical vertebrae (HP:0002949)1.73385535
122Median cleft lip (HP:0000161)1.73056766
123Squamous cell carcinoma (HP:0002860)1.72429146
124Abnormality of the fetal cardiovascular system (HP:0010948)1.71537974
125Abnormal umbilical cord blood vessels (HP:0011403)1.71537974
126Single umbilical artery (HP:0001195)1.71537974
127Neoplasm of the oral cavity (HP:0100649)1.71310837
128Decreased activity of mitochondrial respiratory chain (HP:0008972)1.70889830
129Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.70889830
130Skin tags (HP:0010609)1.70852425
131Stenosis of the external auditory canal (HP:0000402)1.70665652
132Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.70628325
133Abnormal number of incisors (HP:0011064)1.70377249
134Neoplasm of the colon (HP:0100273)1.69981336
135Hepatic necrosis (HP:0002605)1.69926015
136Small hand (HP:0200055)1.69255582
137Missing ribs (HP:0000921)1.69103814
138Overlapping toe (HP:0001845)1.68510555
139Lactic acidosis (HP:0003128)1.67993742
140Glioma (HP:0009733)1.67013009
141Oligodactyly (hands) (HP:0001180)1.66321353
142Abnormality of the distal phalanx of the thumb (HP:0009617)1.66081971
143Abnormal protein N-linked glycosylation (HP:0012347)1.65461310
144Abnormal protein glycosylation (HP:0012346)1.65461310
145Abnormal glycosylation (HP:0012345)1.65461310
146Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.65461310
147Male infertility (HP:0003251)1.64343635
148Abnormality of serum amino acid levels (HP:0003112)1.64015740
149Broad palm (HP:0001169)1.63916040
150Abnormality of the renal collecting system (HP:0004742)1.63330483

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.44291907
2CDC74.33231369
3CDK123.99101543
4TTK3.84505200
5NEK23.63850956
6WEE13.34281984
7BRSK22.59344350
8PLK42.55190658
9PLK12.48249015
10EEF2K2.36255593
11VRK22.28957263
12STK102.27094452
13SRPK12.04508698
14CHEK22.03637359
15BRSK12.02207070
16AURKB2.01833388
17EIF2AK11.91275256
18CDK71.80340068
19NEK11.76056763
20MST41.71040422
21ACVR1B1.62031588
22TRIM281.59208957
23STK161.56943359
24RPS6KB21.46241247
25AURKA1.43536264
26MAP3K81.42867779
27TESK21.37891626
28PLK31.37401041
29TLK11.37040092
30MELK1.36581509
31LATS11.35590378
32CHEK11.33762090
33ATR1.33407523
34LATS21.30322635
35PAK41.29634390
36VRK11.27519304
37RPS6KA41.27507699
38CDK41.26626340
39BRAF1.25968775
40STK41.25621803
41STK31.24182186
42MKNK11.23514217
43PNCK1.20803532
44CCNB11.12800134
45GRK61.09480020
46CDK81.08214565
47MAP3K101.07980038
48NME11.07024431
49TAF11.06860494
50PDK21.06024013
51STK38L1.04931423
52DYRK31.03708753
53TNIK1.00047308
54ATM0.96666101
55MKNK20.95648768
56MOS0.94627037
57CSF1R0.88487962
58WNK30.86568265
59MAPKAPK30.84890046
60MAP3K60.83776181
61CDK20.83770063
62BMPR1B0.82923507
63ERBB40.82445638
64MAP4K20.79181908
65PAK10.75404835
66TAOK10.74421753
67PASK0.74273099
68PLK20.74109856
69EIF2AK20.72334470
70CDK10.70042496
71CDK60.69400056
72BCR0.66162483
73MST1R0.65104227
74SCYL20.64892118
75ERN10.61390189
76RAF10.60161228
77TESK10.58388866
78PIM10.55890501
79GRK50.55355544
80ERBB30.53392084
81NME20.53073554
82PKN20.53051914
83EIF2AK30.53011408
84NEK90.52879033
85CDK90.49918324
86TYRO30.48272908
87EPHA20.46753885
88STK390.46564584
89PBK0.45707574
90AKT20.45222375
91MET0.44839911
92KSR20.44823716
93ZAK0.43596000
94CSNK2A20.42296479
95CSNK1G10.41058665
96TGFBR10.39801927
97WNK40.39673316
98MUSK0.39399321
99PRKCI0.38434187
100TRPM70.37756677
101CSNK2A10.37149553
102MTOR0.36867980
103CDK30.35782445
104MAPK110.35595908
105CSNK1G30.35481984
106DYRK20.34314924
107CLK10.33276831
108MARK30.32160310
109MINK10.31439512
110CSNK1E0.31360064
111MATK0.29550927
112FLT30.29366909
113TSSK60.29069100
114CDK150.28062998
115CDK11A0.27357148
116NEK60.27335068
117LRRK20.27241375
118NUAK10.26624588
119FGFR10.26316343
120BCKDK0.25890787
121CDK180.25301807
122BRD40.25276369
123GRK10.25246397
124KSR10.25041375
125PRKDC0.24783346
126MAPK140.24568077
127ALK0.24343865
128PRKG20.23986377
129TRIB30.23643638
130HIPK20.23442699
131MAPKAPK20.23206165
132ILK0.22257589
133CDK140.22188468
134CSNK1G20.21039044

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.54274164
2Mismatch repair_Homo sapiens_hsa034303.92206061
3Cell cycle_Homo sapiens_hsa041103.87514380
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.30206730
5Homologous recombination_Homo sapiens_hsa034403.27918768
6RNA transport_Homo sapiens_hsa030133.04974841
7Base excision repair_Homo sapiens_hsa034103.00452389
8Spliceosome_Homo sapiens_hsa030402.87198745
9Fanconi anemia pathway_Homo sapiens_hsa034602.80102808
10Nucleotide excision repair_Homo sapiens_hsa034202.57306438
11RNA degradation_Homo sapiens_hsa030182.41537425
12RNA polymerase_Homo sapiens_hsa030202.39158929
13One carbon pool by folate_Homo sapiens_hsa006702.32668645
14Ribosome_Homo sapiens_hsa030102.25420733
15Basal transcription factors_Homo sapiens_hsa030222.23378684
16Vitamin B6 metabolism_Homo sapiens_hsa007502.05363013
17p53 signaling pathway_Homo sapiens_hsa041152.04574430
18mRNA surveillance pathway_Homo sapiens_hsa030152.01873182
19Protein export_Homo sapiens_hsa030601.97191554
20Non-homologous end-joining_Homo sapiens_hsa034501.94473479
21Pyrimidine metabolism_Homo sapiens_hsa002401.94107378
22Oxidative phosphorylation_Homo sapiens_hsa001901.75583146
23Parkinsons disease_Homo sapiens_hsa050121.73087955
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.63850294
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.57995887
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.55160469
27Oocyte meiosis_Homo sapiens_hsa041141.48509543
28Proteasome_Homo sapiens_hsa030501.47877759
29Huntingtons disease_Homo sapiens_hsa050161.46957404
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.46453156
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.41663050
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.32487187
33Pyruvate metabolism_Homo sapiens_hsa006201.28593684
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.27148883
35Propanoate metabolism_Homo sapiens_hsa006401.21432516
36Systemic lupus erythematosus_Homo sapiens_hsa053221.17137729
37MicroRNAs in cancer_Homo sapiens_hsa052061.17080438
38Herpes simplex infection_Homo sapiens_hsa051681.12196846
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.09766199
40Thyroid cancer_Homo sapiens_hsa052161.09391390
41Viral carcinogenesis_Homo sapiens_hsa052031.07955699
42Steroid biosynthesis_Homo sapiens_hsa001001.05872954
43Small cell lung cancer_Homo sapiens_hsa052221.02758376
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.00674042
45Epstein-Barr virus infection_Homo sapiens_hsa051690.99944588
46HTLV-I infection_Homo sapiens_hsa051660.97194145
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.96143931
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.95403898
49Purine metabolism_Homo sapiens_hsa002300.95234256
50Fatty acid elongation_Homo sapiens_hsa000620.93313785
51Alzheimers disease_Homo sapiens_hsa050100.92249137
52Carbon metabolism_Homo sapiens_hsa012000.89688620
53TGF-beta signaling pathway_Homo sapiens_hsa043500.82271482
54Pancreatic cancer_Homo sapiens_hsa052120.81843835
55Sulfur relay system_Homo sapiens_hsa041220.80465997
56Colorectal cancer_Homo sapiens_hsa052100.79014485
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78613323
58Pentose phosphate pathway_Homo sapiens_hsa000300.73415276
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.72324925
60Hippo signaling pathway_Homo sapiens_hsa043900.72180955
61Bladder cancer_Homo sapiens_hsa052190.71218035
62Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70972134
63Basal cell carcinoma_Homo sapiens_hsa052170.69844897
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.66093079
65Linoleic acid metabolism_Homo sapiens_hsa005910.64220317
66Chronic myeloid leukemia_Homo sapiens_hsa052200.63646964
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60945382
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60715766
69Notch signaling pathway_Homo sapiens_hsa043300.59856155
70Antigen processing and presentation_Homo sapiens_hsa046120.59632054
71Apoptosis_Homo sapiens_hsa042100.58868319
72Hepatitis B_Homo sapiens_hsa051610.58843946
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58732995
74Arachidonic acid metabolism_Homo sapiens_hsa005900.58684080
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58233088
76Metabolic pathways_Homo sapiens_hsa011000.57708490
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56935697
78Selenocompound metabolism_Homo sapiens_hsa004500.56195068
79Non-small cell lung cancer_Homo sapiens_hsa052230.56070092
80Fructose and mannose metabolism_Homo sapiens_hsa000510.54872496
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54739344
82Adherens junction_Homo sapiens_hsa045200.53733116
83Pathways in cancer_Homo sapiens_hsa052000.50797877
84mTOR signaling pathway_Homo sapiens_hsa041500.50098682
85Biosynthesis of amino acids_Homo sapiens_hsa012300.48360342
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.48253991
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47247136
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.44589646
89Hedgehog signaling pathway_Homo sapiens_hsa043400.44085299
90Cysteine and methionine metabolism_Homo sapiens_hsa002700.43908766
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43899927
92Sulfur metabolism_Homo sapiens_hsa009200.43260766
93Galactose metabolism_Homo sapiens_hsa000520.43144254
94Ovarian steroidogenesis_Homo sapiens_hsa049130.39003636
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38846242
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38682601
97Alcoholism_Homo sapiens_hsa050340.38582621
98Influenza A_Homo sapiens_hsa051640.38276157
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.38138726
100Shigellosis_Homo sapiens_hsa051310.37850420
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36938371
102Acute myeloid leukemia_Homo sapiens_hsa052210.36696468
103Prostate cancer_Homo sapiens_hsa052150.36654560
104Drug metabolism - other enzymes_Homo sapiens_hsa009830.35116819
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34848685
106Endometrial cancer_Homo sapiens_hsa052130.34634379
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32499908
108Arginine and proline metabolism_Homo sapiens_hsa003300.32485749
109Legionellosis_Homo sapiens_hsa051340.31677287
110Fatty acid metabolism_Homo sapiens_hsa012120.31510349
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31357350
112Phototransduction_Homo sapiens_hsa047440.31069783
113Measles_Homo sapiens_hsa051620.31058792
114NF-kappa B signaling pathway_Homo sapiens_hsa040640.30740239
115Cardiac muscle contraction_Homo sapiens_hsa042600.30252314
116FoxO signaling pathway_Homo sapiens_hsa040680.29387825
117VEGF signaling pathway_Homo sapiens_hsa043700.28225148
118Folate biosynthesis_Homo sapiens_hsa007900.28082206
119Lysine degradation_Homo sapiens_hsa003100.28053506
120Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27805554
121Glutathione metabolism_Homo sapiens_hsa004800.26704646
122Wnt signaling pathway_Homo sapiens_hsa043100.26576386
123Primary immunodeficiency_Homo sapiens_hsa053400.26330769
124Proteoglycans in cancer_Homo sapiens_hsa052050.25659625
125RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.25434595
126Peroxisome_Homo sapiens_hsa041460.23581687
127HIF-1 signaling pathway_Homo sapiens_hsa040660.23260416
128Viral myocarditis_Homo sapiens_hsa054160.23083498
129Regulation of autophagy_Homo sapiens_hsa041400.22864884
130Melanoma_Homo sapiens_hsa052180.22520467
131Caffeine metabolism_Homo sapiens_hsa002320.22500905
132Hematopoietic cell lineage_Homo sapiens_hsa046400.22090292
133Butanoate metabolism_Homo sapiens_hsa006500.22061293
134Cyanoamino acid metabolism_Homo sapiens_hsa004600.21797525
135Other glycan degradation_Homo sapiens_hsa005110.21789035
136Regulation of actin cytoskeleton_Homo sapiens_hsa048100.21706152
137Prolactin signaling pathway_Homo sapiens_hsa049170.21524377
138N-Glycan biosynthesis_Homo sapiens_hsa005100.18971966
139Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18637959
140beta-Alanine metabolism_Homo sapiens_hsa004100.18397499
141Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.18246888
142Fatty acid degradation_Homo sapiens_hsa000710.12692696
143Tryptophan metabolism_Homo sapiens_hsa003800.12159793
144Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.11275287
145Tight junction_Homo sapiens_hsa045300.10626644
146Vitamin digestion and absorption_Homo sapiens_hsa049770.08899270

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