KNDC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a Ras guanine nucleotide exchange factor that appears to negatively regulate dendritic growth in the brain. Knockdown of this gene in senescent umbilical vein endothelial cells partially reversed the senescence, showing that this gene could potentially be targeted by anti-aging therapies. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)8.04837988
2axon ensheathment in central nervous system (GO:0032291)7.72370050
3central nervous system myelination (GO:0022010)7.72370050
4sodium ion export (GO:0071436)5.41389532
5myelination (GO:0042552)5.28825149
6ensheathment of neurons (GO:0007272)5.25361520
7axon ensheathment (GO:0008366)5.25361520
8neuronal action potential propagation (GO:0019227)4.85662080
9fatty acid elongation (GO:0030497)4.69279752
10negative regulation of neurotransmitter secretion (GO:0046929)4.66253191
11positive regulation of synapse maturation (GO:0090129)4.65104608
12transmission of nerve impulse (GO:0019226)4.55172002
13axonemal dynein complex assembly (GO:0070286)4.44463892
14L-amino acid import (GO:0043092)4.34919374
15synaptic vesicle maturation (GO:0016188)4.33720144
16neuron cell-cell adhesion (GO:0007158)4.28961866
17long-chain fatty acid biosynthetic process (GO:0042759)4.27659602
18presynaptic membrane assembly (GO:0097105)4.27184573
19presynaptic membrane organization (GO:0097090)4.23640024
20locomotory exploration behavior (GO:0035641)4.21856854
21negative regulation of neurotransmitter transport (GO:0051589)4.21415738
22regulation of short-term neuronal synaptic plasticity (GO:0048172)4.21200277
23potassium ion homeostasis (GO:0055075)4.18883666
24regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.18882916
25cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.16315924
26positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.09555991
27regulation of neurotransmitter levels (GO:0001505)4.05311851
28postsynaptic membrane organization (GO:0001941)4.01579801
29regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.93345908
30gamma-aminobutyric acid transport (GO:0015812)3.93265890
31neuronal ion channel clustering (GO:0045161)3.91249050
32regulation of ARF protein signal transduction (GO:0032012)3.88751935
33ionotropic glutamate receptor signaling pathway (GO:0035235)3.86114555
34positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.85398317
35positive regulation of dendritic spine development (GO:0060999)3.84491327
36regulation of synaptic plasticity (GO:0048167)3.83538585
37synaptic vesicle endocytosis (GO:0048488)3.82998094
38regulation of synapse structural plasticity (GO:0051823)3.82063085
39neurotransmitter-gated ion channel clustering (GO:0072578)3.81887790
40adult walking behavior (GO:0007628)3.78053020
41potassium ion import (GO:0010107)3.76508454
42cellular sodium ion homeostasis (GO:0006883)3.76263747
43regulation of synaptic vesicle exocytosis (GO:2000300)3.74740372
44regulation of synapse maturation (GO:0090128)3.68413934
45positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.65646131
46cell communication by electrical coupling (GO:0010644)3.64558843
47glycerophospholipid catabolic process (GO:0046475)3.62673298
48synaptic vesicle exocytosis (GO:0016079)3.61611289
49cilium or flagellum-dependent cell motility (GO:0001539)3.60473805
50dendritic spine morphogenesis (GO:0060997)3.60330373
51positive regulation of dendritic spine morphogenesis (GO:0061003)3.58977517
52regulation of vesicle fusion (GO:0031338)3.56915913
53negative regulation of dendrite morphogenesis (GO:0050774)3.54973314
54positive regulation of neurotransmitter transport (GO:0051590)3.54822628
55gamma-aminobutyric acid signaling pathway (GO:0007214)3.48391934
56peptidyl-tyrosine autophosphorylation (GO:0038083)3.48334891
57regulation of neurotransmitter transport (GO:0051588)3.47938253
58glutamate secretion (GO:0014047)3.46241606
59vocalization behavior (GO:0071625)3.45702876
60negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.45387424
61oligodendrocyte differentiation (GO:0048709)3.45145316
62synaptic transmission, glutamatergic (GO:0035249)3.45059545
63positive regulation of neurotransmitter secretion (GO:0001956)3.43895350
64glutamate receptor signaling pathway (GO:0007215)3.38843980
65cytoskeletal anchoring at plasma membrane (GO:0007016)3.38559168
66regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.38267145
67neuron recognition (GO:0008038)3.32045826
68cilium movement (GO:0003341)3.29967675
69amino acid import (GO:0043090)3.29015123
70substantia nigra development (GO:0021762)3.26741515
71neuron-neuron synaptic transmission (GO:0007270)3.26287462
72glycine transport (GO:0015816)3.26184636
73chemosensory behavior (GO:0007635)3.23499704
74neuromuscular process controlling posture (GO:0050884)3.23255906
75positive regulation of membrane potential (GO:0045838)3.21642510
76negative regulation of axonogenesis (GO:0050771)3.17960729
77establishment of mitochondrion localization (GO:0051654)3.15399097
78regulation of dendritic spine development (GO:0060998)3.14837361
79dendritic spine organization (GO:0097061)3.13863895
80regulation of synaptic vesicle transport (GO:1902803)3.11857625
81dendrite morphogenesis (GO:0048813)3.10844122
82positive regulation of action potential (GO:0045760)3.10528883
83acidic amino acid transport (GO:0015800)3.10183781
84membrane depolarization during action potential (GO:0086010)3.09847608
85axonal fasciculation (GO:0007413)3.08678748
86regulation of neuronal synaptic plasticity (GO:0048168)3.07829080
87asymmetric protein localization (GO:0008105)3.07487730
88protein localization to synapse (GO:0035418)3.06743570
89regulation of synaptic transmission (GO:0050804)3.06322540
90regulation of collateral sprouting (GO:0048670)3.05843898
91membrane depolarization (GO:0051899)3.04941227
92negative regulation of protein localization to cell surface (GO:2000009)3.03743427
93G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.03415705
94apical protein localization (GO:0045176)3.02828198
95motile cilium assembly (GO:0044458)3.01528028
96neurotransmitter secretion (GO:0007269)3.01148464
97exploration behavior (GO:0035640)3.00481880
98photoreceptor cell differentiation (GO:0046530)3.00096693
99eye photoreceptor cell differentiation (GO:0001754)3.00096693
100long-term memory (GO:0007616)2.99276765
101peripheral nervous system axon ensheathment (GO:0032292)2.98626895
102myelination in peripheral nervous system (GO:0022011)2.98626895
103proline transport (GO:0015824)2.98002891
104neurotransmitter catabolic process (GO:0042135)2.96029219
105regulation of long-term neuronal synaptic plasticity (GO:0048169)2.95957579
106long-term synaptic potentiation (GO:0060291)2.95188146
107neuromuscular synaptic transmission (GO:0007274)2.95110802
108synaptic transmission (GO:0007268)2.94909901
109cellular response to epinephrine stimulus (GO:0071872)2.92165447
110establishment of synaptic vesicle localization (GO:0097480)2.92148329
111synaptic vesicle transport (GO:0048489)2.92148329
112nerve growth factor signaling pathway (GO:0038180)2.92030519
113myelin maintenance (GO:0043217)2.91787061
114membrane hyperpolarization (GO:0060081)2.91261809
115negative regulation of axon extension (GO:0030517)2.90955026
116regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.90647635
117positive regulation of dendrite development (GO:1900006)2.90517374
118epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.90349122
119activation of protein kinase A activity (GO:0034199)2.89780124
120negative regulation of synaptic transmission, GABAergic (GO:0032229)2.89201384
121regulation of glutamate receptor signaling pathway (GO:1900449)2.89170042
122virion attachment to host cell (GO:0019062)2.88834116
123adhesion of symbiont to host cell (GO:0044650)2.88834116
124cerebral cortex radially oriented cell migration (GO:0021799)2.88758794
125astrocyte development (GO:0014002)2.88181904
126regulation of excitatory postsynaptic membrane potential (GO:0060079)2.87780339
127regulation of voltage-gated calcium channel activity (GO:1901385)2.87404645
128mating behavior (GO:0007617)2.87336888
129membrane tubulation (GO:0097320)2.81418893
130membrane assembly (GO:0071709)2.80343650
131response to methylmercury (GO:0051597)2.79906411
132neurotransmitter transport (GO:0006836)2.79626797
133layer formation in cerebral cortex (GO:0021819)2.75429175
134import into cell (GO:0098657)2.75156778
135regulation of dendritic spine morphogenesis (GO:0061001)2.74869594
136G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.74377540
137neuromuscular process controlling balance (GO:0050885)2.73709439
138cerebellar Purkinje cell differentiation (GO:0021702)2.72748266
139auditory behavior (GO:0031223)2.71208526
140regulation of postsynaptic membrane potential (GO:0060078)2.70944161
141regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.70907175
142membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.68880483
143negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.68626788
144regulation of neurotransmitter secretion (GO:0046928)2.67505669
145adult locomotory behavior (GO:0008344)2.66787660
146cellular potassium ion homeostasis (GO:0030007)2.65708802
147synapse organization (GO:0050808)2.59422890
148neurotransmitter uptake (GO:0001504)2.59137378
149* cerebellar granule cell differentiation (GO:0021707)2.57931553

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.22008874
2GBX2_23144817_ChIP-Seq_PC3_Human3.48457949
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.90526700
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.85891343
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.81547142
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.55745968
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.55745968
8* DROSHA_22980978_ChIP-Seq_HELA_Human2.47734090
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.41420610
10* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.40830683
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.38519340
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.35777552
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.33343905
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.32063257
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.30436945
16EZH2_27294783_Chip-Seq_ESCs_Mouse2.27978786
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.27469178
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.23798524
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.21968708
20REST_21632747_ChIP-Seq_MESCs_Mouse2.16573221
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.06894112
22RARB_27405468_Chip-Seq_BRAIN_Mouse1.99735577
23TAF15_26573619_Chip-Seq_HEK293_Human1.96767941
24SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.95447244
25RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.87282500
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.79118087
27AR_21572438_ChIP-Seq_LNCaP_Human1.76812108
28ZFP281_18757296_ChIP-ChIP_E14_Mouse1.75915730
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.75915158
30* KDM2B_26808549_Chip-Seq_K562_Human1.74223691
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.63535104
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61567353
33OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54780431
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52933419
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51825075
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.51231602
37* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.50179203
38CTCF_27219007_Chip-Seq_Bcells_Human1.49361538
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48682253
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48128334
41CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.47603015
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.45986816
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.45320348
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44872158
45RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44141388
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43950284
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.42788982
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42396244
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.39720842
50ER_23166858_ChIP-Seq_MCF-7_Human1.39274606
51SMAD4_21799915_ChIP-Seq_A2780_Human1.37027734
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36888864
53ZFP281_27345836_Chip-Seq_ESCs_Mouse1.34713682
54TET1_21490601_ChIP-Seq_MESCs_Mouse1.33707318
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33467888
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33358718
57* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.31610718
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.30594660
59MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.30322388
60CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.29824513
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.29387737
62LXR_22292898_ChIP-Seq_THP-1_Human1.27465599
63STAT3_23295773_ChIP-Seq_U87_Human1.25858543
64P300_19829295_ChIP-Seq_ESCs_Human1.25717432
65P53_22127205_ChIP-Seq_FIBROBLAST_Human1.25687862
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.25674117
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24308333
68SMC4_20622854_ChIP-Seq_HELA_Human1.24011842
69RING1B_27294783_Chip-Seq_ESCs_Mouse1.20563528
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20149799
71SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19113039
72TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18152198
73PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16965571
74WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16191657
75RNF2_27304074_Chip-Seq_NSC_Mouse1.15300236
76KDM2B_26808549_Chip-Seq_SUP-B15_Human1.15038326
77ERG_21242973_ChIP-ChIP_JURKAT_Human1.14852455
78ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.13687702
79VDR_22108803_ChIP-Seq_LS180_Human1.13059157
80TCF4_23295773_ChIP-Seq_U87_Human1.11722027
81RING1B_27294783_Chip-Seq_NPCs_Mouse1.11283040
82PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.09508175
83ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09315006
84TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09132312
85* SOX2_21211035_ChIP-Seq_LN229_Gbm1.08668606
86ZNF274_21170338_ChIP-Seq_K562_Hela1.08279585
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07412952
88MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06808020
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06269274
90SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.05617952
91GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04505622
92STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.03784918
93* OCT4_19829295_ChIP-Seq_ESCs_Human1.03397444
94ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02948389
95NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01914417
96NANOG_18555785_Chip-Seq_ESCs_Mouse0.99480544
97AHR_22903824_ChIP-Seq_MCF-7_Human0.98938070
98TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98750202
99* AR_19668381_ChIP-Seq_PC3_Human0.98154212
100ARNT_22903824_ChIP-Seq_MCF-7_Human0.98059419
101CREB1_26743006_Chip-Seq_LNCaP_Human0.97637799
102RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97469764
103* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96800134
104RUNX2_22187159_ChIP-Seq_PCA_Human0.95829156
105FUS_26573619_Chip-Seq_HEK293_Human0.94450545
106SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.94306645
107NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93441616
108CMYC_18555785_Chip-Seq_ESCs_Mouse0.93313783
109SRY_22984422_ChIP-ChIP_TESTIS_Rat0.92582938
110AR_25329375_ChIP-Seq_VCAP_Human0.92457563
111LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92089106
112PRDM14_20953172_ChIP-Seq_ESCs_Human0.90745908
113KLF4_19829295_ChIP-Seq_ESCs_Human0.90212721
114TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89926387
115CTNNB1_20460455_ChIP-Seq_HCT116_Human0.89916951
116GATA1_26923725_Chip-Seq_HPCs_Mouse0.89508330
117SMAD_19615063_ChIP-ChIP_OVARY_Human0.89344621
118EP300_21415370_ChIP-Seq_HL-1_Mouse0.89213499
119SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.88984448
120* P68_20966046_ChIP-Seq_HELA_Human0.88868618
121TRIM28_21343339_ChIP-Seq_HEK293_Human0.88782459
122TP53_16413492_ChIP-PET_HCT116_Human0.88718457
123SMAD4_21741376_ChIP-Seq_HESCs_Human0.88353128
124* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88114491
125WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.87964144
126YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87375479
127EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.87182335
128DPY_21335234_ChIP-Seq_ESCs_Mouse0.87095401
129DNAJC2_21179169_ChIP-ChIP_NT2_Human0.86814866
130SMAD4_21741376_ChIP-Seq_EPCs_Human0.86370753
131TBL1_22424771_ChIP-Seq_293T_Human0.84419741
132OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.84360316
133MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.83541336
134SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81159269
135* SMAD4_21741376_ChIP-Seq_ESCs_Human0.79906425
136DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.78965401
137TP53_20018659_ChIP-ChIP_R1E_Mouse0.78433950
138SMAD3_21741376_ChIP-Seq_ESCs_Human0.76223187
139TP53_23651856_ChIP-Seq_MEFs_Mouse0.74656169
140CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.73347974
141PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.71423312
142* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.70288515
143KDM2B_26808549_Chip-Seq_DND41_Human0.69944375
144MYC_27129775_Chip-Seq_CORNEA_Mouse0.68437460

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.08484611
2MP0004859_abnormal_synaptic_plasticity4.87069928
3MP0004270_analgesia3.77876416
4MP0000920_abnormal_myelination3.68389710
5MP0009046_muscle_twitch3.33981839
6MP0003635_abnormal_synaptic_transmissio3.31173795
7MP0002064_seizures3.10761151
8MP0002272_abnormal_nervous_system3.02756315
9MP0009745_abnormal_behavioral_response2.93802210
10MP0001486_abnormal_startle_reflex2.89151580
11MP0005423_abnormal_somatic_nervous2.72883771
12MP0003690_abnormal_glial_cell2.62116398
13MP0004885_abnormal_endolymph2.55843763
14MP0002734_abnormal_mechanical_nocicepti2.50342710
15MP0002063_abnormal_learning/memory/cond2.45710457
16MP0003329_amyloid_beta_deposits2.42513397
17MP0004742_abnormal_vestibular_system2.28363563
18MP0002572_abnormal_emotion/affect_behav2.24691719
19MP0000778_abnormal_nervous_system2.20014104
20MP0004142_abnormal_muscle_tone2.11649975
21MP0001440_abnormal_grooming_behavior2.08990854
22MP0008569_lethality_at_weaning2.05474875
23MP0001485_abnormal_pinna_reflex1.98608140
24MP0001968_abnormal_touch/_nociception1.96488879
25MP0002067_abnormal_sensory_capabilities1.89534049
26MP0001905_abnormal_dopamine_level1.86788893
27MP0001529_abnormal_vocalization1.82469461
28MP0001501_abnormal_sleep_pattern1.80050928
29MP0003634_abnormal_glial_cell1.79251398
30MP0000955_abnormal_spinal_cord1.74087423
31MP0002733_abnormal_thermal_nociception1.73703722
32MP0001970_abnormal_pain_threshold1.72042706
33MP0005171_absent_coat_pigmentation1.65377343
34MP0002229_neurodegeneration1.64255365
35MP0002735_abnormal_chemical_nociception1.61338454
36MP0003123_paternal_imprinting1.61060221
37MP0004924_abnormal_behavior1.60146861
38MP0005386_behavior/neurological_phenoty1.60146861
39MP0002882_abnormal_neuron_morphology1.59994397
40MP0003632_abnormal_nervous_system1.59066385
41MP0002066_abnormal_motor_capabilities/c1.55073379
42MP0005645_abnormal_hypothalamus_physiol1.54231031
43MP0005409_darkened_coat_color1.53252969
44MP0004145_abnormal_muscle_electrophysio1.50772511
45MP0002184_abnormal_innervation1.48455588
46MP0002736_abnormal_nociception_after1.45976017
47MP0002653_abnormal_ependyma_morphology1.43503750
48MP0002557_abnormal_social/conspecific_i1.39082501
49MP0003631_nervous_system_phenotype1.34045638
50MP0001346_abnormal_lacrimal_gland1.33685367
51MP0003633_abnormal_nervous_system1.28652456
52MP0002822_catalepsy1.28230156
53MP0004811_abnormal_neuron_physiology1.24606958
54MP0001502_abnormal_circadian_rhythm1.23712604
55MP0003136_yellow_coat_color1.22919927
56MP0005551_abnormal_eye_electrophysiolog1.21868135
57MP0001963_abnormal_hearing_physiology1.18036826
58MP0003950_abnormal_plasma_membrane1.18023839
59MP0004147_increased_porphyrin_level1.16869616
60MP0006276_abnormal_autonomic_nervous1.16019010
61MP0005646_abnormal_pituitary_gland1.15856336
62MP0000604_amyloidosis1.14778230
63MP0001348_abnormal_lacrimal_gland1.13623579
64MP0002152_abnormal_brain_morphology1.11817459
65MP0005410_abnormal_fertilization1.10798814
66MP0002752_abnormal_somatic_nervous1.09653498
67MP0001299_abnormal_eye_distance/1.07866697
68MP0001984_abnormal_olfaction1.06736674
69MP0002909_abnormal_adrenal_gland1.06143695
70MP0005623_abnormal_meninges_morphology0.98575857
71MP0000462_abnormal_digestive_system0.97712978
72MP0003787_abnormal_imprinting0.95840170
73MP0001177_atelectasis0.94812450
74MP0003075_altered_response_to0.92541784
75MP0010678_abnormal_skin_adnexa0.89869465
76MP0009780_abnormal_chondrocyte_physiolo0.88548783
77MP0008875_abnormal_xenobiotic_pharmacok0.84430852
78MP0000383_abnormal_hair_follicle0.84171082
79MP0005394_taste/olfaction_phenotype0.81491884
80MP0005499_abnormal_olfactory_system0.81491884
81MP0002638_abnormal_pupillary_reflex0.81075343
82MP0003879_abnormal_hair_cell0.80180198
83MP0003283_abnormal_digestive_organ0.78833669
84MP0000747_muscle_weakness0.78690391
85MP0004043_abnormal_pH_regulation0.77835362
86MP0005167_abnormal_blood-brain_barrier0.77579620
87MP0004858_abnormal_nervous_system0.76632747
88MP0003137_abnormal_impulse_conducting0.75836924
89MP0002249_abnormal_larynx_morphology0.75810292
90MP0003938_abnormal_ear_development0.75587628
91MP0000026_abnormal_inner_ear0.75567852
92MP0002069_abnormal_eating/drinking_beha0.73888885
93MP0008874_decreased_physiological_sensi0.70605465
94MP0003122_maternal_imprinting0.70261380
95MP0005377_hearing/vestibular/ear_phenot0.69463956
96MP0003878_abnormal_ear_physiology0.69463956
97MP0005310_abnormal_salivary_gland0.69372195
98MP0005535_abnormal_body_temperature0.65804104
99MP0000631_abnormal_neuroendocrine_gland0.65076524
100MP0006072_abnormal_retinal_apoptosis0.64807067
101MP0000579_abnormal_nail_morphology0.63762442
102MP0003861_abnormal_nervous_system0.61472664
103MP0005195_abnormal_posterior_eye0.59575980
104MP0005253_abnormal_eye_physiology0.56921733
105MP0005451_abnormal_body_composition0.56920138
106MP0008872_abnormal_physiological_respon0.56512125
107MP0001943_abnormal_respiration0.56235471
108MP0000751_myopathy0.55955922
109MP0001188_hyperpigmentation0.55599101
110MP0001765_abnormal_ion_homeostasis0.54560215
111MP0008877_abnormal_DNA_methylation0.54453902
112MP0004085_abnormal_heartbeat0.53586276
113MP0001986_abnormal_taste_sensitivity0.53554487
114MP0010769_abnormal_survival0.52966586
115MP0002090_abnormal_vision0.52088503
116MP0004133_heterotaxia0.51900047
117MP0000566_synostosis0.51739482
118MP0010768_mortality/aging0.51412534
119MP0002082_postnatal_lethality0.51071908
120MP0010770_preweaning_lethality0.50069974

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.57610373
2Degeneration of the lateral corticospinal tracts (HP:0002314)5.20164218
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.20164218
4Neurofibrillary tangles (HP:0002185)5.17372452
5Myokymia (HP:0002411)5.08395448
6Abnormal respiratory epithelium morphology (HP:0012253)5.05065011
7Abnormal respiratory motile cilium morphology (HP:0005938)5.05065011
8Focal motor seizures (HP:0011153)4.76232025
9Abnormality of the corticospinal tract (HP:0002492)4.62923202
10Sensory axonal neuropathy (HP:0003390)4.55548491
11Supranuclear gaze palsy (HP:0000605)4.52610177
12Rhinitis (HP:0012384)4.30058899
13Intention tremor (HP:0002080)4.28480577
14Atonic seizures (HP:0010819)4.17489159
15Spastic gait (HP:0002064)4.13274489
16Dysmetria (HP:0001310)4.12392510
17Peripheral hypomyelination (HP:0007182)4.03466929
18Obstructive sleep apnea (HP:0002870)3.86660645
19Focal seizures (HP:0007359)3.82699205
20Action tremor (HP:0002345)3.81837763
21Cerebral inclusion bodies (HP:0100314)3.78642810
22Scanning speech (HP:0002168)3.69895459
23Progressive cerebellar ataxia (HP:0002073)3.56864282
24Annular pancreas (HP:0001734)3.55005991
25Akinesia (HP:0002304)3.54531015
26Papilledema (HP:0001085)3.53672849
27Torticollis (HP:0000473)3.44278660
28Parakeratosis (HP:0001036)3.43691898
29Gaze-evoked nystagmus (HP:0000640)3.39158199
30Ankle clonus (HP:0011448)3.29538867
31Epileptic encephalopathy (HP:0200134)3.27256281
32Onion bulb formation (HP:0003383)3.22753763
33Cerebral hypomyelination (HP:0006808)3.21169377
34Chronic bronchitis (HP:0004469)3.18200644
35Broad-based gait (HP:0002136)2.98917820
36Dysdiadochokinesis (HP:0002075)2.94223459
37Tetraplegia (HP:0002445)2.91711656
38Sleep apnea (HP:0010535)2.90764243
39Nasal polyposis (HP:0100582)2.88379565
40Focal dystonia (HP:0004373)2.86290989
41Hemiplegia (HP:0002301)2.84715987
42Visual hallucinations (HP:0002367)2.84453624
43Slow saccadic eye movements (HP:0000514)2.83697867
44Bronchiectasis (HP:0002110)2.77900235
45Alacrima (HP:0000522)2.72342519
46Craniofacial dystonia (HP:0012179)2.63949415
47Status epilepticus (HP:0002133)2.63173660
48Termporal pattern (HP:0011008)2.62603035
49Insidious onset (HP:0003587)2.62603035
50Absence seizures (HP:0002121)2.55117890
51Dialeptic seizures (HP:0011146)2.53193743
52Lower limb muscle weakness (HP:0007340)2.51178154
53Retinal dysplasia (HP:0007973)2.50191682
54Epileptiform EEG discharges (HP:0011182)2.50006986
55Increased circulating renin level (HP:0000848)2.49379382
56Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.47789288
57Urinary bladder sphincter dysfunction (HP:0002839)2.40060405
58Abnormal eating behavior (HP:0100738)2.37476204
59Progressive inability to walk (HP:0002505)2.35385202
60Pheochromocytoma (HP:0002666)2.34741173
61Abnormality of the nasal mucosa (HP:0000433)2.33083791
62Febrile seizures (HP:0002373)2.32362033
63Dynein arm defect of respiratory motile cilia (HP:0012255)2.30804204
64Absent/shortened dynein arms (HP:0200106)2.30804204
65Abnormal auditory evoked potentials (HP:0006958)2.29965884
66Delusions (HP:0000746)2.29285425
67Ventricular fibrillation (HP:0001663)2.28273685
68Bradykinesia (HP:0002067)2.27565316
69Generalized tonic-clonic seizures (HP:0002069)2.27378261
70Urinary urgency (HP:0000012)2.25305778
71Abnormality of saccadic eye movements (HP:0000570)2.24728004
72Impaired smooth pursuit (HP:0007772)2.24408785
73Postural instability (HP:0002172)2.23293515
74Fetal akinesia sequence (HP:0001989)2.21521424
75Thickened helices (HP:0000391)2.20914222
76Abnormality of the lower motor neuron (HP:0002366)2.20639597
77Hyperventilation (HP:0002883)2.20538137
78EEG with generalized epileptiform discharges (HP:0011198)2.19300180
79Generalized myoclonic seizures (HP:0002123)2.18497316
80Mutism (HP:0002300)2.16478302
81Split foot (HP:0001839)2.16159920
82Aplasia involving bones of the upper limbs (HP:0009823)2.16099674
83Aplasia of the phalanges of the hand (HP:0009802)2.16099674
84Aplasia involving bones of the extremities (HP:0009825)2.16099674
85Decreased lacrimation (HP:0000633)2.15823391
86Amblyopia (HP:0000646)2.15195871
87Clonus (HP:0002169)2.15164851
88Anxiety (HP:0000739)2.14481689
89Truncal ataxia (HP:0002078)2.13365879
90Lower limb asymmetry (HP:0100559)2.13342784
91Megalencephaly (HP:0001355)2.12528811
92Anteriorly placed anus (HP:0001545)2.11913448
93Morphological abnormality of the pyramidal tract (HP:0002062)2.11560309
94CNS hypomyelination (HP:0003429)2.10547202
95Insomnia (HP:0100785)2.10208290
96Impaired vibration sensation in the lower limbs (HP:0002166)2.09796830
97Hemiparesis (HP:0001269)2.07223776
98Abnormal ciliary motility (HP:0012262)2.06785055
99Hypsarrhythmia (HP:0002521)2.06287038
100Depression (HP:0000716)2.05310587
101Neuroendocrine neoplasm (HP:0100634)2.04881846
102Polyphagia (HP:0002591)2.02270173
103Spastic tetraparesis (HP:0001285)2.01275815
104Spastic paraparesis (HP:0002313)2.00759068
105Hand muscle atrophy (HP:0009130)1.99493730
106Infertility (HP:0000789)1.98335706
107Apathy (HP:0000741)1.97911355
108Diplopia (HP:0000651)1.96376625
109Abnormality of binocular vision (HP:0011514)1.96376625
110Rigidity (HP:0002063)1.95630349
111Metabolic alkalosis (HP:0200114)1.95001790
112Abnormal social behavior (HP:0012433)1.94625628
113Bronchomalacia (HP:0002780)1.94609698
114Limb dystonia (HP:0002451)1.93700810
115Impaired vibratory sensation (HP:0002495)1.93043713
116Stereotypic behavior (HP:0000733)1.92450195
117Abnormality of ocular smooth pursuit (HP:0000617)1.92431726
118Clumsiness (HP:0002312)1.92052706
119Genetic anticipation (HP:0003743)1.91031283
120Neuronal loss in central nervous system (HP:0002529)1.90711898
121Turricephaly (HP:0000262)1.88621383
122Cerebral hemorrhage (HP:0001342)1.88423043
123Absent septum pellucidum (HP:0001331)1.88402697
124Bowel incontinence (HP:0002607)1.87808948
125Morphological abnormality of the inner ear (HP:0011390)1.87196202
126Leukodystrophy (HP:0002415)1.86490979
127Diminished movement (HP:0002374)1.83483207
128Poor eye contact (HP:0000817)1.83033357
129Absent speech (HP:0001344)1.82804369
130Abnormal respiratory motile cilium physiology (HP:0012261)1.81760259
131Hypomagnesemia (HP:0002917)1.80912184
132Poor speech (HP:0002465)1.80435998
133Choreoathetosis (HP:0001266)1.78926795
134Distal upper limb amyotrophy (HP:0007149)1.78482992
135Upper limb amyotrophy (HP:0009129)1.78482992
136Urinary incontinence (HP:0000020)1.76709102
137Spinal canal stenosis (HP:0003416)1.76552181
138Excessive salivation (HP:0003781)1.75058255
139Drooling (HP:0002307)1.75058255
140Premature skin wrinkling (HP:0100678)1.74874830
141Hypoplastic pelvis (HP:0008839)1.72668190
142Decreased motor nerve conduction velocity (HP:0003431)1.72336210
143Blue irides (HP:0000635)1.72131158
144Impaired social interactions (HP:0000735)1.71065792

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.79270806
2TNIK3.98071650
3OXSR13.93712404
4CDK192.93652510
5EPHA42.43491595
6EPHB12.40235869
7NTRK32.40020727
8PRPF4B2.39912544
9BCR2.22319458
10PAK62.18436958
11MARK12.15420525
12WNK12.05630785
13UHMK12.04922063
14RIPK11.95926351
15MAP3K91.92625470
16ICK1.91877825
17MAPK151.88252877
18NEK61.87722685
19PNCK1.81401314
20NTRK11.77904503
21PKN11.77272004
22WNK41.72714590
23NTRK21.58305422
24SIK21.57564448
25RIPK41.55225123
26TYRO31.49229532
27FGFR21.47820967
28LATS21.47138463
29MINK11.46924952
30MAP3K41.44224568
31CASK1.43297285
32CDK51.31798080
33MAPKAPK51.29367062
34DAPK11.27221774
35ROCK21.26763574
36CAMK2B1.25489850
37CSNK1G31.22805296
38CSNK1A1L1.15675013
39CSNK1G21.14530261
40SGK2231.12314875
41SGK4941.12314875
42PAK31.10855984
43MAPK131.10169755
44MET1.10001602
45LIMK11.08039961
46MAP2K71.05032155
47CAMK2D1.04304343
48FGR1.03876659
49CDK140.98976224
50KSR20.97144092
51CDK150.95851956
52SGK20.95548114
53CDK180.92873370
54PHKG10.91589747
55PHKG20.91589747
56CAMK2A0.91128194
57FES0.88019527
58CAMK2G0.86912477
59CSNK1G10.86438821
60SGK30.85924684
61CDK11A0.85797128
62MAP3K130.83515020
63STK110.83385227
64IRAK20.82421416
65CLK10.81286849
66MARK20.79378836
67ARAF0.77552382
68MAPK120.76368957
69DAPK20.76023794
70BRSK10.74737378
71MAP3K110.73196012
72PRKCH0.73172661
73PRKD30.73050885
74PRKCG0.72624534
75PDPK10.71958027
76TNK20.71497291
77CAMK40.68422206
78MAP2K40.67830062
79GRK50.66774503
80FYN0.65106668
81ALK0.62799652
82CAMKK10.60803240
83PRKCQ0.59767346
84CAMKK20.59394739
85MAP3K20.59271983
86PBK0.59198977
87DYRK1A0.57481177
88PRKCE0.57183683
89CAMK10.55875443
90MUSK0.53156629
91PLK20.51297610
92KSR10.50761351
93DAPK30.50428320
94PDK10.50343377
95LMTK20.50311596
96ERBB20.49694988
97PRKG10.46682265
98BRAF0.46292687
99CAMK1G0.45531130
100ADRBK20.45367054
101BMPR20.45129743
102MAPK100.44413881
103SGK10.44173878
104TESK10.43383395
105CSNK1D0.41022230
106ROCK10.40063490
107PRKD10.39185470
108DYRK20.38343642
109STK380.38331804
110CSNK1A10.37995723
111PRKCA0.36718767
112MAP3K10.36171962
113PINK10.35963255
114MAP3K120.35860097
115CDC42BPA0.34331654
116RPS6KA30.34182900
117PRKCZ0.33599280
118IRAK10.33446286
119PRKACB0.33176371
120RET0.32549650
121RPS6KA20.31268058
122MAPK80.30512450
123SRC0.29008506
124EEF2K0.27572763
125PRKACA0.27030443

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.26776981
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.02940052
3Glutamatergic synapse_Homo sapiens_hsa047242.66998749
4GABAergic synapse_Homo sapiens_hsa047272.65109708
5Synaptic vesicle cycle_Homo sapiens_hsa047212.57611084
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.44266791
7Morphine addiction_Homo sapiens_hsa050322.28101745
8Steroid biosynthesis_Homo sapiens_hsa001002.25207881
9Circadian entrainment_Homo sapiens_hsa047132.17434171
10Axon guidance_Homo sapiens_hsa043602.06681398
11Ether lipid metabolism_Homo sapiens_hsa005651.96568108
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.94810576
13Fatty acid elongation_Homo sapiens_hsa000621.91757240
14Long-term depression_Homo sapiens_hsa047301.91409688
15Long-term potentiation_Homo sapiens_hsa047201.86313500
16Salivary secretion_Homo sapiens_hsa049701.86197379
17Serotonergic synapse_Homo sapiens_hsa047261.85927677
18Olfactory transduction_Homo sapiens_hsa047401.73919128
19Dopaminergic synapse_Homo sapiens_hsa047281.64612230
20Amphetamine addiction_Homo sapiens_hsa050311.63442504
21Cholinergic synapse_Homo sapiens_hsa047251.54701666
22Gastric acid secretion_Homo sapiens_hsa049711.53917339
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.53474700
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.53322444
25Taste transduction_Homo sapiens_hsa047421.52152036
26Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.46882562
27Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.37810233
28Collecting duct acid secretion_Homo sapiens_hsa049661.35885857
29Cocaine addiction_Homo sapiens_hsa050301.32723104
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.30698476
31Insulin secretion_Homo sapiens_hsa049111.20336989
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20109764
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.18728490
34Calcium signaling pathway_Homo sapiens_hsa040201.16068622
35Sphingolipid metabolism_Homo sapiens_hsa006001.15659601
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.14849498
37Phospholipase D signaling pathway_Homo sapiens_hsa040721.14482842
38Oxytocin signaling pathway_Homo sapiens_hsa049211.12256126
39Aldosterone synthesis and secretion_Homo sapiens_hsa049251.11815370
40cAMP signaling pathway_Homo sapiens_hsa040241.08145003
41Renin secretion_Homo sapiens_hsa049241.07571167
42Bile secretion_Homo sapiens_hsa049761.04513482
43Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.04453654
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.04069152
45ErbB signaling pathway_Homo sapiens_hsa040121.03300457
46Vibrio cholerae infection_Homo sapiens_hsa051101.03287728
47Dorso-ventral axis formation_Homo sapiens_hsa043201.02786159
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.02189663
49Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01775393
50Cardiac muscle contraction_Homo sapiens_hsa042601.00605586
51Gap junction_Homo sapiens_hsa045401.00349785
52Histidine metabolism_Homo sapiens_hsa003400.99995198
53Pancreatic secretion_Homo sapiens_hsa049720.97690472
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.97354963
55GnRH signaling pathway_Homo sapiens_hsa049120.95641881
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94659873
57Renal cell carcinoma_Homo sapiens_hsa052110.93619646
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.91919301
59Endocytosis_Homo sapiens_hsa041440.87913501
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87832805
61Sphingolipid signaling pathway_Homo sapiens_hsa040710.87644286
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85762380
63Oxidative phosphorylation_Homo sapiens_hsa001900.84525439
64Prion diseases_Homo sapiens_hsa050200.83113969
65Ras signaling pathway_Homo sapiens_hsa040140.82450964
66Choline metabolism in cancer_Homo sapiens_hsa052310.82164532
67Butanoate metabolism_Homo sapiens_hsa006500.79822711
68Nitrogen metabolism_Homo sapiens_hsa009100.79679023
69Alzheimers disease_Homo sapiens_hsa050100.78124728
70Type II diabetes mellitus_Homo sapiens_hsa049300.75849027
71Tight junction_Homo sapiens_hsa045300.74801566
72Ovarian steroidogenesis_Homo sapiens_hsa049130.73147754
73Phototransduction_Homo sapiens_hsa047440.69147460
74Melanogenesis_Homo sapiens_hsa049160.68560987
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.68521374
76MAPK signaling pathway_Homo sapiens_hsa040100.68441121
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67487407
78Estrogen signaling pathway_Homo sapiens_hsa049150.67153317
79beta-Alanine metabolism_Homo sapiens_hsa004100.64205823
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.62576819
81Phenylalanine metabolism_Homo sapiens_hsa003600.62498935
82Rheumatoid arthritis_Homo sapiens_hsa053230.62435449
83VEGF signaling pathway_Homo sapiens_hsa043700.61217908
84Vitamin B6 metabolism_Homo sapiens_hsa007500.60506793
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59516222
86Thyroid hormone synthesis_Homo sapiens_hsa049180.58274776
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57809622
88Glucagon signaling pathway_Homo sapiens_hsa049220.57043120
89Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56106358
90Linoleic acid metabolism_Homo sapiens_hsa005910.55370883
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54321972
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53974671
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51494963
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51469629
95Circadian rhythm_Homo sapiens_hsa047100.50091233
96Fatty acid biosynthesis_Homo sapiens_hsa000610.49388188
97Inositol phosphate metabolism_Homo sapiens_hsa005620.47301350
98Sulfur metabolism_Homo sapiens_hsa009200.47276011
99Arginine and proline metabolism_Homo sapiens_hsa003300.45617263
100Arginine biosynthesis_Homo sapiens_hsa002200.45587945
101Dilated cardiomyopathy_Homo sapiens_hsa054140.44331291
102Hedgehog signaling pathway_Homo sapiens_hsa043400.43934507
103Wnt signaling pathway_Homo sapiens_hsa043100.43519652
104Alcoholism_Homo sapiens_hsa050340.43459075
105Autoimmune thyroid disease_Homo sapiens_hsa053200.43399576
106Mineral absorption_Homo sapiens_hsa049780.43106960
107Parkinsons disease_Homo sapiens_hsa050120.42528483
108Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42385455
109Chemokine signaling pathway_Homo sapiens_hsa040620.40719872
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40325222
111Rap1 signaling pathway_Homo sapiens_hsa040150.37024133
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35868366
113Glioma_Homo sapiens_hsa052140.35325157
114Oocyte meiosis_Homo sapiens_hsa041140.34354469
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33625224
116Hippo signaling pathway_Homo sapiens_hsa043900.32875348
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32398410
118Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.28220628
119Insulin signaling pathway_Homo sapiens_hsa049100.27906465
120ABC transporters_Homo sapiens_hsa020100.27217948
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26763453
122mTOR signaling pathway_Homo sapiens_hsa041500.23826566
123AMPK signaling pathway_Homo sapiens_hsa041520.22597361

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