KMT2C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a nuclear protein with an AT hook DNA-binding domain, a DHHC-type zinc finger, six PHD-type zinc fingers, a SET domain, a post-SET domain and a RING-type zinc finger. This protein is a member of the ASC-2/NCOA6 complex (ASCOM), which possesses histone methylation activity and is involved in transcriptional coactivation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K4 trimethylation (GO:0080182)5.40505141
2cytoplasmic mRNA processing body assembly (GO:0033962)4.59978642
3mitotic sister chromatid cohesion (GO:0007064)4.40090186
4* histone H3-K4 methylation (GO:0051568)4.20852932
5peptidyl-lysine trimethylation (GO:0018023)4.13798305
6oocyte development (GO:0048599)4.01425590
7histone H3-K36 demethylation (GO:0070544)3.98316179
8cellular response to ethanol (GO:0071361)3.97984982
9negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.84420653
10negative regulation of translation, ncRNA-mediated (GO:0040033)3.84420653
11regulation of translation, ncRNA-mediated (GO:0045974)3.84420653
12retrograde transport, vesicle recycling within Golgi (GO:0000301)3.63867478
13histone lysine demethylation (GO:0070076)3.61772881
14* histone lysine methylation (GO:0034968)3.51555849
15N-terminal protein amino acid acetylation (GO:0006474)3.48120165
16protein targeting to Golgi (GO:0000042)3.45707026
17protein K11-linked deubiquitination (GO:0035871)3.42880748
18histone demethylation (GO:0016577)3.41171471
19regulation of pigment cell differentiation (GO:0050932)3.38656871
20histone H3-K9 demethylation (GO:0033169)3.38327886
21stress granule assembly (GO:0034063)3.31555453
22establishment of protein localization to Golgi (GO:0072600)3.26474182
23regulation of RNA export from nucleus (GO:0046831)3.23083046
24positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.21396192
25regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.21396192
26histone H3-K9 methylation (GO:0051567)3.18730689
27interkinetic nuclear migration (GO:0022027)3.17746067
28lipid translocation (GO:0034204)3.10627242
29phospholipid translocation (GO:0045332)3.10627242
30monoubiquitinated protein deubiquitination (GO:0035520)3.10212798
31negative regulation of histone methylation (GO:0031061)3.10025696
32histone H3-K9 modification (GO:0061647)3.08039300
33positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.07253048
34regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.07253048
35cerebellar Purkinje cell differentiation (GO:0021702)3.07179045
36positive regulation of developmental pigmentation (GO:0048087)3.07010618
37regulation of acrosome reaction (GO:0060046)3.05921204
38embryonic retina morphogenesis in camera-type eye (GO:0060059)3.05422038
39regulation of establishment of cell polarity (GO:2000114)3.04194415
40protein dealkylation (GO:0008214)3.03068880
41protein demethylation (GO:0006482)3.03068880
42regulation of clathrin-mediated endocytosis (GO:2000369)2.97602841
43negative regulation of neurotransmitter secretion (GO:0046929)2.95292233
44nucleus localization (GO:0051647)2.94820292
45peptidyl-lysine methylation (GO:0018022)2.94427450
46microtubule anchoring (GO:0034453)2.91388080
47regulation of ARF protein signal transduction (GO:0032012)2.87839887
48regulation of nucleobase-containing compound transport (GO:0032239)2.87583185
49establishment of nucleus localization (GO:0040023)2.83339677
50nuclear pore complex assembly (GO:0051292)2.83199474
51positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.82567434
52negative regulation of neurotransmitter transport (GO:0051589)2.79009186
53regulation of histone H3-K4 methylation (GO:0051569)2.76555547
54pre-miRNA processing (GO:0031054)2.74982604
55regulation of protein polyubiquitination (GO:1902914)2.74719399
56* histone methylation (GO:0016571)2.73504667
57phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.69030545
58histone H4-K16 acetylation (GO:0043984)2.67037767
59Golgi to endosome transport (GO:0006895)2.65092671
60regulation of histone H3-K27 methylation (GO:0061085)2.63556700
61sister chromatid cohesion (GO:0007062)2.62281949
62regulation of female gonad development (GO:2000194)2.59893891
63histone mRNA catabolic process (GO:0071044)2.57263317
64growth hormone receptor signaling pathway (GO:0060396)2.56852379
65protein localization to Golgi apparatus (GO:0034067)2.55535648
66negative regulation of cAMP-mediated signaling (GO:0043951)2.54528935
67positive regulation of histone deacetylation (GO:0031065)2.54296998
68negative regulation of cell killing (GO:0031342)2.53607959
69negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.53607959
70peptidyl-threonine phosphorylation (GO:0018107)2.51126586
71positive regulation of mRNA catabolic process (GO:0061014)2.51075827
72neural tube formation (GO:0001841)2.51015636
73regulation of mRNA catabolic process (GO:0061013)2.49746491
74corticosteroid receptor signaling pathway (GO:0031958)2.49565398
75positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.49228494
76protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.47686665
77macroautophagy (GO:0016236)2.47587909
78regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.47258697
79regulation of B cell receptor signaling pathway (GO:0050855)2.46332021
80NLS-bearing protein import into nucleus (GO:0006607)2.45316557
81regulation of sister chromatid cohesion (GO:0007063)2.43454532
82snRNA transcription (GO:0009301)2.43307653
83positive regulation of gene expression, epigenetic (GO:0045815)2.42295322
84positive regulation of mRNA 3-end processing (GO:0031442)2.40822170
85regulation of mRNA 3-end processing (GO:0031440)2.40546554
86glucocorticoid receptor signaling pathway (GO:0042921)2.40296576
87regulation of establishment or maintenance of cell polarity (GO:0032878)2.39063988
88interleukin-6-mediated signaling pathway (GO:0070102)2.38872150
89regulation of gamma-delta T cell differentiation (GO:0045586)2.37560899
90positive T cell selection (GO:0043368)2.37507979
91definitive hemopoiesis (GO:0060216)2.36837057
92positive regulation of macroautophagy (GO:0016239)2.34605232
93protein K63-linked deubiquitination (GO:0070536)2.34448385
94retinal cone cell development (GO:0046549)2.34088409
95pericardium development (GO:0060039)2.32441540
96histone deubiquitination (GO:0016578)2.31853713
97negative regulation of circadian rhythm (GO:0042754)2.30833253
98peptidyl-threonine modification (GO:0018210)2.30456742
99striated muscle atrophy (GO:0014891)2.30434393
100regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.29495910
101embryonic hemopoiesis (GO:0035162)2.29018176
102regulation of histone methylation (GO:0031060)2.29001546
103early endosome to late endosome transport (GO:0045022)2.28239186
104negative regulation of hormone metabolic process (GO:0032351)2.28117573
105negative regulation of hormone biosynthetic process (GO:0032353)2.28117573
106embryonic camera-type eye morphogenesis (GO:0048596)2.27800346
107DNA methylation (GO:0006306)2.27722142
108DNA alkylation (GO:0006305)2.27722142
109negative regulation of histone modification (GO:0031057)2.27403592
110centrosome localization (GO:0051642)2.27287007
111positive regulation of DNA-templated transcription, initiation (GO:2000144)2.25535462
112intra-Golgi vesicle-mediated transport (GO:0006891)2.24754153
113positive regulation of granulocyte differentiation (GO:0030854)2.24360720
114microtubule nucleation (GO:0007020)2.23781676
115mitotic chromosome condensation (GO:0007076)2.22369471
116insulin-like growth factor receptor signaling pathway (GO:0048009)2.22336275
117regulation of gamma-delta T cell activation (GO:0046643)2.22075814
118poly(A)+ mRNA export from nucleus (GO:0016973)2.21659081
119nerve growth factor signaling pathway (GO:0038180)2.20752733
120cellular response to growth hormone stimulus (GO:0071378)2.20160165
121genitalia morphogenesis (GO:0035112)2.19339291
122retinal rod cell development (GO:0046548)2.19331955
123antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.19056985
124DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.18599180
125histone acetylation (GO:0016573)2.18244269
126neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.18028357
127heart morphogenesis (GO:0003007)2.17264115
128coronary vasculature morphogenesis (GO:0060977)2.16849473
129fibroblast migration (GO:0010761)2.15089782
130regulation of histone deacetylation (GO:0031063)2.13319070
131positive regulation of mRNA processing (GO:0050685)2.12313701
132pore complex assembly (GO:0046931)2.12067994
133eye photoreceptor cell development (GO:0042462)2.11493568
134histone H4 acetylation (GO:0043967)2.11004126
135protein K48-linked deubiquitination (GO:0071108)2.10102525
136nuclear pore organization (GO:0006999)2.09978549
137positive regulation of gamma-delta T cell activation (GO:0046645)2.09283692
138internal peptidyl-lysine acetylation (GO:0018393)2.08662958

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human2.94304023
2SMAD_19615063_ChIP-ChIP_OVARY_Human2.68461226
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.64521657
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.46907124
5SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.43557931
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.36438235
7GBX2_23144817_ChIP-Seq_PC3_Human2.35440421
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.30713418
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.24290032
10TP53_16413492_ChIP-PET_HCT116_Human1.96208089
11ZNF217_24962896_ChIP-Seq_MCF-7_Human1.93858546
12AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.85845532
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.83266819
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.79721904
15POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74809393
16VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.74483367
17RUNX_20019798_ChIP-Seq_JUKART_Human1.70135017
18STAT3_23295773_ChIP-Seq_U87_Human1.66986999
19DROSHA_22980978_ChIP-Seq_HELA_Human1.65730679
20AHR_22903824_ChIP-Seq_MCF-7_Human1.65264302
21TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.64665721
22AR_21572438_ChIP-Seq_LNCaP_Human1.57802809
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.56651150
24DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.56506919
25SMAD4_21799915_ChIP-Seq_A2780_Human1.55826558
26ER_23166858_ChIP-Seq_MCF-7_Human1.55769020
27ARNT_22903824_ChIP-Seq_MCF-7_Human1.55015346
28TAF15_26573619_Chip-Seq_HEK293_Human1.54951928
29FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.53346589
30POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.51925439
31TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51925439
32TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.50101703
33FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.49852791
34SCL_19346495_ChIP-Seq_HPC-7_Human1.48318142
35HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.48206243
36TCF4_23295773_ChIP-Seq_U87_Human1.47468228
37CTNNB1_20460455_ChIP-Seq_HCT116_Human1.46940188
38KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.42611878
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39803715
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.37821250
41TCF4_18268006_ChIP-ChIP_LS174T_Human1.37234093
42RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35321769
43GATA1_22025678_ChIP-Seq_K562_Human1.34339204
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30989467
45MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29377532
46PKCTHETA_26484144_Chip-Seq_BREAST_Human1.28973792
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27855289
48CBP_20019798_ChIP-Seq_JUKART_Human1.27855289
49TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27815698
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27296269
51AR_19668381_ChIP-Seq_PC3_Human1.26035576
52STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.25411366
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25029251
54TP63_19390658_ChIP-ChIP_HaCaT_Human1.24211360
55PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.24184939
56ISL1_27105846_Chip-Seq_CPCs_Mouse1.23192734
57KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22271268
58FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21223657
59NANOG_18555785_Chip-Seq_ESCs_Mouse1.20984281
60NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.20716398
61FOXM1_23109430_ChIP-Seq_U2OS_Human1.20589520
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20198456
63YAP1_20516196_ChIP-Seq_MESCs_Mouse1.20108476
64FLI1_21867929_ChIP-Seq_TH2_Mouse1.19948625
65TBL1_22424771_ChIP-Seq_293T_Human1.19662792
66IGF1R_20145208_ChIP-Seq_DFB_Human1.19421696
67FLI1_27457419_Chip-Seq_LIVER_Mouse1.19114172
68CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18354664
69SOX2_21211035_ChIP-Seq_LN229_Gbm1.16621454
70EZH2_22144423_ChIP-Seq_EOC_Human1.16524492
71* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15772672
72RXR_22108803_ChIP-Seq_LS180_Human1.15760715
73VDR_24787735_ChIP-Seq_THP-1_Human1.15116281
74AR_25329375_ChIP-Seq_VCAP_Human1.13436915
75TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.12977433
76EZH2_27294783_Chip-Seq_NPCs_Mouse1.12419509
77CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11823576
78FOXA2_19822575_ChIP-Seq_HepG2_Human1.11804969
79FUS_26573619_Chip-Seq_HEK293_Human1.11328891
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10572826
81TBX3_20139965_ChIP-Seq_ESCs_Mouse1.10245583
82TBX3_20139965_ChIP-Seq_MESCs_Mouse1.10140732
83SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09774712
84ESR1_20079471_ChIP-ChIP_T-47D_Human1.09752537
85ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.09296316
86P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09208041
87CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.08670791
88P300_19829295_ChIP-Seq_ESCs_Human1.08415639
89PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07367420
90VDR_22108803_ChIP-Seq_LS180_Human1.07110547
91Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.06266550
92KDM2B_26808549_Chip-Seq_JURKAT_Human1.06088251
93SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.04940810
94PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04296199
95STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.03404946
96BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03326477
97OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03217245
98NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02957175
99EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02349335
100TCF7_22412390_ChIP-Seq_EML_Mouse1.02041683
101RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.01878188
102KDM2B_26808549_Chip-Seq_REH_Human1.01702290
103SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.00926868
104ZNF274_21170338_ChIP-Seq_K562_Hela1.00528394
105ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99683502
106AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.99398847
107TCF4_22108803_ChIP-Seq_LS180_Human0.98905147
108SMAD3_21741376_ChIP-Seq_EPCs_Human0.98607503
109TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98308007
110CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98216161
111FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98029175
112BCAT_22108803_ChIP-Seq_LS180_Human0.97907252
113EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97876282
114EWS_26573619_Chip-Seq_HEK293_Human0.97656138
115E2F1_18555785_Chip-Seq_ESCs_Mouse0.97541743
116TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96623755
117CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96597518
118RARB_27405468_Chip-Seq_BRAIN_Mouse0.95950451
119KDM2B_26808549_Chip-Seq_DND41_Human0.95921243
120KDM2B_26808549_Chip-Seq_K562_Human0.95356820
121EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.95242318
122SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93287412
123SMAD3_21741376_ChIP-Seq_HESCs_Human0.93040749
124RUNX2_22187159_ChIP-Seq_PCA_Human0.92227892
125SMAD3_21741376_ChIP-Seq_ESCs_Human0.92172257
126ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91715159
127STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.90497851
128PRDM14_20953172_ChIP-Seq_ESCs_Human0.90407662
129FOXO3_23340844_ChIP-Seq_DLD1_Human0.89742606
130SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89384302
131CTBP1_25329375_ChIP-Seq_LNCAP_Human0.89235500
132MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89208719
133EGR1_19374776_ChIP-ChIP_THP-1_Human0.87219699

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.42814531
2MP0003787_abnormal_imprinting3.76166060
3MP0004381_abnormal_hair_follicle2.68469974
4MP0002009_preneoplasia2.51213019
5MP0005551_abnormal_eye_electrophysiolog2.45968435
6MP0003045_fibrosis2.45057245
7MP0008961_abnormal_basal_metabolism2.18507355
8MP0008877_abnormal_DNA_methylation2.18054251
9MP0006072_abnormal_retinal_apoptosis2.04761498
10MP0002166_altered_tumor_susceptibility2.04685855
11MP0005076_abnormal_cell_differentiation2.03756806
12MP0003890_abnormal_embryonic-extraembry2.00359202
13MP0003656_abnormal_erythrocyte_physiolo1.96459729
14MP0004043_abnormal_pH_regulation1.92244566
15MP0003183_abnormal_peptide_metabolism1.88157068
16MP0000383_abnormal_hair_follicle1.82022522
17MP0004264_abnormal_extraembryonic_tissu1.81115922
18MP0004885_abnormal_endolymph1.77525526
19MP0003121_genomic_imprinting1.71027146
20MP0009780_abnormal_chondrocyte_physiolo1.62799003
21MP0010678_abnormal_skin_adnexa1.61303836
22MP0005253_abnormal_eye_physiology1.57562281
23MP0002006_tumorigenesis1.55765424
24MP0003646_muscle_fatigue1.52482433
25MP0005423_abnormal_somatic_nervous1.50504688
26MP0005187_abnormal_penis_morphology1.50306360
27MP0001299_abnormal_eye_distance/1.49410090
28MP0003950_abnormal_plasma_membrane1.48460419
29MP0003195_calcinosis1.48432374
30MP0003300_gastrointestinal_ulcer1.47806542
31MP0010307_abnormal_tumor_latency1.45396388
32MP0006292_abnormal_olfactory_placode1.39807318
33MP0008057_abnormal_DNA_replication1.38063137
34MP0003763_abnormal_thymus_physiology1.37351373
35MP0009115_abnormal_fat_cell1.36554837
36MP0000003_abnormal_adipose_tissue1.35170196
37MP0005310_abnormal_salivary_gland1.35023815
38MP0001502_abnormal_circadian_rhythm1.34742216
39MP0002396_abnormal_hematopoietic_system1.33659507
40MP0004185_abnormal_adipocyte_glucose1.31070912
41MP0002877_abnormal_melanocyte_morpholog1.29965707
42MP0004808_abnormal_hematopoietic_stem1.29941831
43MP0001486_abnormal_startle_reflex1.29827407
44MP0005670_abnormal_white_adipose1.27321783
45MP0005174_abnormal_tail_pigmentation1.26860132
46MP0010352_gastrointestinal_tract_polyps1.26037467
47MP0000015_abnormal_ear_pigmentation1.24472064
48MP0009278_abnormal_bone_marrow1.19643167
49MP0004134_abnormal_chest_morphology1.19267746
50MP0005646_abnormal_pituitary_gland1.17709860
51MP0000778_abnormal_nervous_system1.17448534
52MP0009703_decreased_birth_body1.15965196
53MP0004270_analgesia1.15271823
54MP0005075_abnormal_melanosome_morpholog1.14598029
55MP0005395_other_phenotype1.11369856
56MP0003935_abnormal_craniofacial_develop1.08841971
57MP0005647_abnormal_sex_gland1.08203627
58MP0005397_hematopoietic_system_phenotyp1.07270564
59MP0001545_abnormal_hematopoietic_system1.07270564
60MP0005375_adipose_tissue_phenotype1.06080973
61MP0003690_abnormal_glial_cell1.04645495
62MP0000631_abnormal_neuroendocrine_gland1.04341535
63MP0003943_abnormal_hepatobiliary_system1.04027144
64MP0005666_abnormal_adipose_tissue1.03926933
65MP0004859_abnormal_synaptic_plasticity1.03263119
66MP0004484_altered_response_of1.02289137
67MP0003172_abnormal_lysosome_physiology1.01701027
68MP0005391_vision/eye_phenotype1.01022249
69MP0000733_abnormal_muscle_development1.00344513
70MP0005645_abnormal_hypothalamus_physiol0.99435925
71MP0002332_abnormal_exercise_endurance0.99048910
72MP0004036_abnormal_muscle_relaxation0.98883180
73MP0005409_darkened_coat_color0.97732243
74MP0002928_abnormal_bile_duct0.97580307
75MP0004130_abnormal_muscle_cell0.95927068
76MP0000566_synostosis0.95812015
77MP0005195_abnormal_posterior_eye0.95030227
78MP0008569_lethality_at_weaning0.94964886
79MP0002229_neurodegeneration0.94885924
80MP0004084_abnormal_cardiac_muscle0.93938615
81MP0003937_abnormal_limbs/digits/tail_de0.93690530
82MP0000470_abnormal_stomach_morphology0.93582044
83MP0000427_abnormal_hair_cycle0.93148748
84MP0002108_abnormal_muscle_morphology0.92794970
85MP0000703_abnormal_thymus_morphology0.92622540
86MP0008995_early_reproductive_senescence0.88225870
87MP0005266_abnormal_metabolism0.87448024
88MP0005220_abnormal_exocrine_pancreas0.86580501
89MP0001984_abnormal_olfaction0.86419149
90MP0004145_abnormal_muscle_electrophysio0.84101214
91MP0001501_abnormal_sleep_pattern0.83980088
92MP0000432_abnormal_head_morphology0.83620987
93MP0001986_abnormal_taste_sensitivity0.83003110
94MP0001188_hyperpigmentation0.82852230
95MP0005379_endocrine/exocrine_gland_phen0.80765945
96MP0000579_abnormal_nail_morphology0.80016929
97MP0003091_abnormal_cell_migration0.79882857
98MP0003868_abnormal_feces_composition0.79159227
99MP0000428_abnormal_craniofacial_morphol0.79096777
100MP0002084_abnormal_developmental_patter0.79042145
101MP0003252_abnormal_bile_duct0.78697597
102MP0002075_abnormal_coat/hair_pigmentati0.78659531
103MP0003632_abnormal_nervous_system0.77657405
104MP0005248_abnormal_Harderian_gland0.77214225
105MP0002925_abnormal_cardiovascular_devel0.76783923
106MP0003635_abnormal_synaptic_transmissio0.76752250
107MP0000371_diluted_coat_color0.76578301
108MP0001324_abnormal_eye_pigmentation0.76244280
109MP0003866_abnormal_defecation0.75923825
110MP0002168_other_aberrant_phenotype0.75812704
111MP0002095_abnormal_skin_pigmentation0.75768061
112MP0001944_abnormal_pancreas_morphology0.74727139
113MP0002909_abnormal_adrenal_gland0.73785652
114MP0002653_abnormal_ependyma_morphology0.73260555
115MP0003111_abnormal_nucleus_morphology0.72851436
116MP0004883_abnormal_blood_vessel0.72606900
117MP0003861_abnormal_nervous_system0.71861928
118MP0002882_abnormal_neuron_morphology0.71746735
119MP0002152_abnormal_brain_morphology0.71275190
120MP0001851_eye_inflammation0.70603840
121MP0001879_abnormal_lymphatic_vessel0.70363855
122MP0005386_behavior/neurological_phenoty0.70294820
123MP0004924_abnormal_behavior0.70294820
124MP0003633_abnormal_nervous_system0.70254543
125MP0005499_abnormal_olfactory_system0.70159331
126MP0005394_taste/olfaction_phenotype0.70159331
127MP0003984_embryonic_growth_retardation0.69460847
128MP0003699_abnormal_female_reproductive0.68992810
129MP0009046_muscle_twitch0.68923474
130MP0005621_abnormal_cell_physiology0.68128452
131MP0000350_abnormal_cell_proliferation0.67844633
132MP0003631_nervous_system_phenotype0.67638496
133MP0004510_myositis0.67329180
134MP0001784_abnormal_fluid_regulation0.66680845
135MP0002088_abnormal_embryonic_growth/wei0.66549366
136MP0000462_abnormal_digestive_system0.66546151
137MP0001672_abnormal_embryogenesis/_devel0.66266003
138MP0001929_abnormal_gametogenesis0.64870818
139MP0009697_abnormal_copulation0.63855477
140MP0003828_pulmonary_edema0.62544293
141MP0002127_abnormal_cardiovascular_syste0.60604163
142MP0002078_abnormal_glucose_homeostasis0.59818546
143MP0001800_abnormal_humoral_immune0.59055555
144MP0002398_abnormal_bone_marrow0.58432395
145MP0002067_abnormal_sensory_capabilities0.58376421

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)5.52345331
2Volvulus (HP:0002580)4.02842948
3Lip pit (HP:0100267)3.62654168
4Macroorchidism (HP:0000053)3.46037398
5Hyperventilation (HP:0002883)3.44610715
6Papillary thyroid carcinoma (HP:0002895)3.31210389
7Gaze-evoked nystagmus (HP:0000640)3.13617099
8Anal stenosis (HP:0002025)3.08014189
9Long eyelashes (HP:0000527)3.06249960
10Narrow palate (HP:0000189)2.99972255
11Genetic anticipation (HP:0003743)2.93969157
12Urethral obstruction (HP:0000796)2.92749880
13Congenital stationary night blindness (HP:0007642)2.82630511
14Hyperkalemia (HP:0002153)2.81615463
15Fair hair (HP:0002286)2.60668240
16Truncal obesity (HP:0001956)2.58621088
17Heterotopia (HP:0002282)2.58510445
18Trigonocephaly (HP:0000243)2.55686405
19Oligodactyly (hands) (HP:0001180)2.55065801
20Generalized hypopigmentation of hair (HP:0011358)2.47120436
21Bony spicule pigmentary retinopathy (HP:0007737)2.45592993
22Tubulointerstitial nephritis (HP:0001970)2.44434968
23Prominent nose (HP:0000448)2.44025673
24Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.41810431
25Acute myeloid leukemia (HP:0004808)2.40569722
26Abnormality of the ischium (HP:0003174)2.37405295
27Obsessive-compulsive behavior (HP:0000722)2.37186202
28Abnormality of the nasal septum (HP:0000419)2.27876517
29Ectopic kidney (HP:0000086)2.27426294
30Abnormality of the renal cortex (HP:0011035)2.25356028
31Hypoplastic ischia (HP:0003175)2.24686877
32Neoplasm of the oral cavity (HP:0100649)2.21719763
33Tented upper lip vermilion (HP:0010804)2.20519468
34Laryngomalacia (HP:0001601)2.19197101
35Aqueductal stenosis (HP:0002410)2.19147266
36Short chin (HP:0000331)2.18783917
37Overgrowth (HP:0001548)2.18556422
38Depressed nasal tip (HP:0000437)2.18159939
39Hypoplastic iliac wings (HP:0002866)2.17716202
40Drooling (HP:0002307)2.17067280
41Excessive salivation (HP:0003781)2.17067280
42Sparse lateral eyebrow (HP:0005338)2.16520546
43Thyroiditis (HP:0100646)2.12883502
44Abnormality of incisor morphology (HP:0011063)2.09670830
45Short 4th metacarpal (HP:0010044)2.08801506
46Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.08801506
47Neonatal hypoglycemia (HP:0001998)2.08133831
48Central scotoma (HP:0000603)2.03055896
49Midline defect of the nose (HP:0004122)2.02762665
50Pigmentary retinal degeneration (HP:0001146)2.01409161
51Transitional cell carcinoma of the bladder (HP:0006740)2.01407134
52Widely spaced teeth (HP:0000687)2.01168813
53Facial hemangioma (HP:0000329)1.98730613
54Chorioretinal atrophy (HP:0000533)1.98283055
55Abnormality of the labia majora (HP:0012881)1.97140832
56Neoplasm of the tracheobronchial system (HP:0100552)1.94508354
57Obstructive sleep apnea (HP:0002870)1.93784332
58Prostate neoplasm (HP:0100787)1.93576038
59Abnormality of the columella (HP:0009929)1.93190078
60Hypochromic microcytic anemia (HP:0004840)1.90859947
61Absent speech (HP:0001344)1.89872315
62Chronic hepatic failure (HP:0100626)1.89507288
63Autoimmune hemolytic anemia (HP:0001890)1.89283890
64Abnormality of the renal medulla (HP:0100957)1.88976870
65Neoplasm of striated muscle (HP:0009728)1.88153664
66Colitis (HP:0002583)1.86470550
67Progressive cerebellar ataxia (HP:0002073)1.86302338
68Abnormal hair whorl (HP:0010721)1.85982517
69Absent frontal sinuses (HP:0002688)1.85961664
70Cystic hygroma (HP:0000476)1.85747956
71Rhabdomyosarcoma (HP:0002859)1.85192004
72T lymphocytopenia (HP:0005403)1.81211823
73Long clavicles (HP:0000890)1.79613516
74Thick eyebrow (HP:0000574)1.78964060
75Curly hair (HP:0002212)1.78728113
76Febrile seizures (HP:0002373)1.78547717
77Subacute progressive viral hepatitis (HP:0006572)1.77843687
78Abnormality of chromosome segregation (HP:0002916)1.77058573
79Blue irides (HP:0000635)1.76958439
80Bladder carcinoma (HP:0002862)1.76814829
81Bladder neoplasm (HP:0009725)1.76814829
82Abnormality of macular pigmentation (HP:0008002)1.76679625
83Chromsome breakage (HP:0040012)1.76175673
84Germ cell neoplasia (HP:0100728)1.75162865
85Oligodactyly (HP:0012165)1.73150358
86Thyroid carcinoma (HP:0002890)1.72268764
87Anteriorly placed anus (HP:0001545)1.72191227
88Leiomyosarcoma (HP:0100243)1.71141910
89Uterine leiomyosarcoma (HP:0002891)1.71141910
90Abnormality of T cell number (HP:0011839)1.69575816
91Synophrys (HP:0000664)1.69184130
92Abnormality of the epiphyses of the hand (HP:0005924)1.69163641
93Sandal gap (HP:0001852)1.68331503
94Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.68124687
95Low anterior hairline (HP:0000294)1.66610187
96Acute lymphatic leukemia (HP:0006721)1.66202324
97Neoplasm of the adrenal cortex (HP:0100641)1.65825988
98Hypoplastic labia majora (HP:0000059)1.65653366
99Deep philtrum (HP:0002002)1.65424833
100Intestinal fistula (HP:0100819)1.64995576
101Chromosomal breakage induced by crosslinking agents (HP:0003221)1.64463306
102Cubitus valgus (HP:0002967)1.64273197
103Difficulty running (HP:0009046)1.63823765
104Mask-like facies (HP:0000298)1.63663991
105Hypoplastic nipples (HP:0002557)1.63435195
106Hepatoblastoma (HP:0002884)1.63278488
107Impaired smooth pursuit (HP:0007772)1.62888308
108Oligodontia (HP:0000677)1.62523737
109Hypoplasia of the maxilla (HP:0000327)1.62006575
110Urinary bladder sphincter dysfunction (HP:0002839)1.61370911
111Highly arched eyebrow (HP:0002553)1.61311623
112Shawl scrotum (HP:0000049)1.61168796
113Dyschromatopsia (HP:0007641)1.60960420
114Tapered finger (HP:0001182)1.60793916
115Dysmetric saccades (HP:0000641)1.60479681
116Broad palm (HP:0001169)1.60006945
117Type II diabetes mellitus (HP:0005978)1.59942993
118Vertebral arch anomaly (HP:0008438)1.58322441
119Limited elbow extension (HP:0001377)1.58308041
120Submucous cleft hard palate (HP:0000176)1.58107603
121Dislocated radial head (HP:0003083)1.58093357
122Abnormal delayed hypersensitivity skin test (HP:0002963)1.57838349
123Scotoma (HP:0000575)1.57579866
124Broad thumb (HP:0011304)1.57035436
125Insulin-resistant diabetes mellitus (HP:0000831)1.56701645
126Broad-based gait (HP:0002136)1.56226647
127Pendular nystagmus (HP:0012043)1.55464002
128Protruding tongue (HP:0010808)1.55413162
129Macular degeneration (HP:0000608)1.55107036
130Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.55022199
131Intestinal atresia (HP:0011100)1.54859568
132Poor coordination (HP:0002370)1.54398263
133Nephronophthisis (HP:0000090)1.53334159
134Abnormality of ocular smooth pursuit (HP:0000617)1.53236248
135Cupped ear (HP:0000378)1.53211312
136Ureteral obstruction (HP:0006000)1.52948477
137Impulsivity (HP:0100710)1.52640024
138Menstrual irregularities (HP:0000858)1.52213133
139Action tremor (HP:0002345)1.51450269
140Abnormal rod and cone electroretinograms (HP:0008323)1.50914561
141Astrocytoma (HP:0009592)1.49722170
142Abnormality of the astrocytes (HP:0100707)1.49722170
143Macrotia (HP:0000400)1.48831274
144Abnormality of homocysteine metabolism (HP:0010919)1.48558617
145Homocystinuria (HP:0002156)1.48558617
146Stomach cancer (HP:0012126)1.48095913
147Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.47292713
148Open mouth (HP:0000194)1.46910534
149Enlarged penis (HP:0000040)1.46605632
150Glioma (HP:0009733)1.46423053
151Supernumerary ribs (HP:0005815)1.46392054

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS15.10101998
2CDK124.00149440
3CAMK1G3.42895388
4CAMK1D3.37148668
5BRD42.51469016
6TAOK32.13612680
7SGK21.90518128
8NUAK11.89881872
9FGFR21.85233135
10FER1.83369252
11SGK31.74819051
12INSRR1.69871249
13SIK21.59908913
14FES1.52870166
15STK31.51790041
16STK38L1.50106221
17STK381.49909572
18FGFR31.49330300
19ACVR1B1.45474798
20PDGFRB1.45093483
21DMPK1.43752779
22NTRK21.42548720
23TRPM71.42101039
24MARK21.41413014
25FRK1.37745027
26CDK91.36676742
27TNK21.36380679
28MAP3K61.35751127
29AKT31.33082937
30SGK2231.26777658
31SGK4941.26777658
32HIPK21.24881514
33IRAK11.24639074
34WNK11.22640914
35CDK31.21323489
36PIK3CG1.20936301
37MAP3K41.20064491
38CASK1.16471584
39MAP3K71.09509065
40MELK1.05707711
41CDC71.05469432
42MAP4K21.05112238
43BLK1.03832538
44MAP3K131.02377785
45LATS21.02134943
46MTOR1.01942552
47JAK11.00693276
48MAP3K20.99497535
49TAOK10.99054879
50SIK10.98210383
51BMPR1B0.94532882
52PRKAA10.94300253
53SGK10.93437646
54PRKAA20.92646561
55PKN20.90452529
56PNCK0.89650988
57PAK30.88834294
58RIPK40.86571361
59TEC0.86486920
60MAPK100.84377648
61CHEK20.83418324
62RET0.83155799
63ATM0.83017474
64CSNK1A1L0.81111710
65PRKCH0.80159314
66CDC42BPA0.78322044
67CHUK0.78249836
68TYRO30.77402337
69YES10.75616136
70CAMK40.75171525
71RIPK10.75041467
72TNIK0.74777031
73PTK2B0.73376744
74NTRK30.72536690
75PRKD20.71661066
76STK390.70733753
77EEF2K0.68545722
78STK110.68193146
79MARK10.68187290
80IKBKE0.67754141
81NEK20.67163346
82MAPK130.66398114
83BTK0.65977375
84CHEK10.65039524
85ATR0.63597606
86MAPK140.63294954
87CDK60.63270865
88IRAK20.62979596
89GSK3B0.62744226
90TXK0.61743569
91OBSCN0.60688811
92CSNK1D0.58429639
93DYRK1A0.58324934
94ITK0.58215468
95ERBB20.56363869
96EPHA30.55401147
97MAPK70.54012699
98MAP4K10.53873535
99PIK3CA0.53531822
100JAK30.52686692
101CDK10.52655530
102SIK30.51787952
103PAK60.51316760
104STK100.51128280
105BRSK20.49979144
106CDK20.48888618
107MAP3K100.48404569
108MST40.48186768
109CAMK10.47847050
110PDGFRA0.47712165
111CAMKK20.47668680
112STK40.47483678
113RPS6KA30.47115633
114PRKDC0.46153207
115MAPK80.45960384
116HCK0.45158900
117MAP3K140.44720290
118NEK60.44709228
119MKNK20.43673202
120MAPK110.43586818
121WNK30.42764960
122ZAK0.42514463
123FGFR40.42509349
124PDK10.42356188
125SYK0.42300685
126CSNK1G20.42119046
127AKT10.41752143
128WNK40.41284807
129PLK20.41019654
130NLK0.40109924
131MARK30.40098072
132PRKD10.39986042
133MAPK10.39905677
134MAP3K90.39684634
135JAK20.39258129
136PRKD30.39077191
137CSNK1G10.38850345
138CSF1R0.37654636
139RPS6KB10.35139958

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.23236784
2Circadian rhythm_Homo sapiens_hsa047101.82729195
3Type II diabetes mellitus_Homo sapiens_hsa049301.77829843
4* Lysine degradation_Homo sapiens_hsa003101.75986104
5Phosphatidylinositol signaling system_Homo sapiens_hsa040701.72133033
6Dorso-ventral axis formation_Homo sapiens_hsa043201.68314234
7Thyroid hormone signaling pathway_Homo sapiens_hsa049191.56680087
8Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.47333734
9mTOR signaling pathway_Homo sapiens_hsa041501.39633144
10Inositol phosphate metabolism_Homo sapiens_hsa005621.30187434
11Carbohydrate digestion and absorption_Homo sapiens_hsa049731.29330472
12Choline metabolism in cancer_Homo sapiens_hsa052311.23676125
13Insulin secretion_Homo sapiens_hsa049111.23204071
14Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.17803273
15Glutamatergic synapse_Homo sapiens_hsa047241.15248309
16MicroRNAs in cancer_Homo sapiens_hsa052061.15217452
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.14065649
18Long-term potentiation_Homo sapiens_hsa047201.13818949
19Pancreatic cancer_Homo sapiens_hsa052121.13554024
20ErbB signaling pathway_Homo sapiens_hsa040121.12797628
21Longevity regulating pathway - mammal_Homo sapiens_hsa042111.12550093
22Endometrial cancer_Homo sapiens_hsa052131.12286104
23Nicotine addiction_Homo sapiens_hsa050331.11541750
24Circadian entrainment_Homo sapiens_hsa047131.10538083
25T cell receptor signaling pathway_Homo sapiens_hsa046601.05759662
26FoxO signaling pathway_Homo sapiens_hsa040681.05387170
27cAMP signaling pathway_Homo sapiens_hsa040241.04405364
28cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03405216
29Non-small cell lung cancer_Homo sapiens_hsa052231.03376267
30Salivary secretion_Homo sapiens_hsa049701.03247778
31Chronic myeloid leukemia_Homo sapiens_hsa052201.02653833
32Morphine addiction_Homo sapiens_hsa050321.02392510
33Cholinergic synapse_Homo sapiens_hsa047251.02300913
34Adherens junction_Homo sapiens_hsa045201.01339986
35Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.01143351
36Colorectal cancer_Homo sapiens_hsa052101.00792309
37GnRH signaling pathway_Homo sapiens_hsa049121.00248331
38Primary immunodeficiency_Homo sapiens_hsa053400.99599661
39B cell receptor signaling pathway_Homo sapiens_hsa046620.99388844
40Prostate cancer_Homo sapiens_hsa052150.99208914
41Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.99136585
42Renal cell carcinoma_Homo sapiens_hsa052110.98670057
43Prolactin signaling pathway_Homo sapiens_hsa049170.97422662
44Notch signaling pathway_Homo sapiens_hsa043300.96381852
45Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95469818
46Renin secretion_Homo sapiens_hsa049240.95091827
47Phospholipase D signaling pathway_Homo sapiens_hsa040720.94488968
48Glioma_Homo sapiens_hsa052140.94062249
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.90600091
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.88836189
51Oxytocin signaling pathway_Homo sapiens_hsa049210.87421812
52Insulin resistance_Homo sapiens_hsa049310.86848259
53GABAergic synapse_Homo sapiens_hsa047270.86698269
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.86392713
55MAPK signaling pathway_Homo sapiens_hsa040100.85263117
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84187359
57Wnt signaling pathway_Homo sapiens_hsa043100.83661210
58Taste transduction_Homo sapiens_hsa047420.83306057
59Long-term depression_Homo sapiens_hsa047300.82686337
60Chemokine signaling pathway_Homo sapiens_hsa040620.81769571
61Estrogen signaling pathway_Homo sapiens_hsa049150.81468730
62Gastric acid secretion_Homo sapiens_hsa049710.79924983
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79541093
64Olfactory transduction_Homo sapiens_hsa047400.78855980
65Measles_Homo sapiens_hsa051620.78220558
66Pancreatic secretion_Homo sapiens_hsa049720.78144748
67Dopaminergic synapse_Homo sapiens_hsa047280.78020557
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.77012240
69Small cell lung cancer_Homo sapiens_hsa052220.76042654
70Ether lipid metabolism_Homo sapiens_hsa005650.75891996
71Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.74687213
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.74589123
73Fatty acid biosynthesis_Homo sapiens_hsa000610.74517796
74Osteoclast differentiation_Homo sapiens_hsa043800.73393171
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72657169
76NF-kappa B signaling pathway_Homo sapiens_hsa040640.72584802
77Platelet activation_Homo sapiens_hsa046110.72363150
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.71342585
79Ovarian steroidogenesis_Homo sapiens_hsa049130.70666561
80VEGF signaling pathway_Homo sapiens_hsa043700.70338737
81TNF signaling pathway_Homo sapiens_hsa046680.70092667
82Calcium signaling pathway_Homo sapiens_hsa040200.69558146
83Thyroid hormone synthesis_Homo sapiens_hsa049180.69343312
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68711997
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68476999
86Dilated cardiomyopathy_Homo sapiens_hsa054140.68423085
87ABC transporters_Homo sapiens_hsa020100.68129637
88Fanconi anemia pathway_Homo sapiens_hsa034600.66043516
89AMPK signaling pathway_Homo sapiens_hsa041520.65973948
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65242528
91mRNA surveillance pathway_Homo sapiens_hsa030150.64211551
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.63782470
93TGF-beta signaling pathway_Homo sapiens_hsa043500.63361083
94Amphetamine addiction_Homo sapiens_hsa050310.63259980
95Ras signaling pathway_Homo sapiens_hsa040140.63172916
96Proteoglycans in cancer_Homo sapiens_hsa052050.63143742
97Hepatitis C_Homo sapiens_hsa051600.62897331
98Insulin signaling pathway_Homo sapiens_hsa049100.62811745
99Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.62778246
100HIF-1 signaling pathway_Homo sapiens_hsa040660.62773436
101Axon guidance_Homo sapiens_hsa043600.62222204
102Basal cell carcinoma_Homo sapiens_hsa052170.61709511
103Acute myeloid leukemia_Homo sapiens_hsa052210.61682025
104Pathways in cancer_Homo sapiens_hsa052000.61447834
105Non-homologous end-joining_Homo sapiens_hsa034500.61208720
106Hepatitis B_Homo sapiens_hsa051610.59946071
107Cocaine addiction_Homo sapiens_hsa050300.59182356
108AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58661676
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.58197735
110Glucagon signaling pathway_Homo sapiens_hsa049220.57582635
111Serotonergic synapse_Homo sapiens_hsa047260.56462642
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.56011455
113Influenza A_Homo sapiens_hsa051640.55850074
114Oocyte meiosis_Homo sapiens_hsa041140.53986261

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