KLKP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.62559437
2detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)5.37254258
3primary amino compound metabolic process (GO:1901160)5.26194897
4serotonin metabolic process (GO:0042428)4.90871234
5detection of light stimulus involved in sensory perception (GO:0050962)4.73501076
6detection of light stimulus involved in visual perception (GO:0050908)4.73501076
7positive regulation of prostaglandin secretion (GO:0032308)4.66486761
8phosphatidylserine acyl-chain remodeling (GO:0036150)4.16740541
9indolalkylamine metabolic process (GO:0006586)4.09607834
10neuronal action potential propagation (GO:0019227)4.06164491
11tryptophan catabolic process (GO:0006569)3.96332890
12indole-containing compound catabolic process (GO:0042436)3.96332890
13indolalkylamine catabolic process (GO:0046218)3.96332890
14indole-containing compound metabolic process (GO:0042430)3.95703572
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.92288527
16kynurenine metabolic process (GO:0070189)3.88412436
17phosphatidylinositol acyl-chain remodeling (GO:0036149)3.83080521
18retinal cone cell development (GO:0046549)3.66500488
19positive regulation of fatty acid transport (GO:2000193)3.64881292
20regulation of prostaglandin secretion (GO:0032306)3.61739803
21platelet dense granule organization (GO:0060155)3.53857180
22phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.51671304
23positive regulation of icosanoid secretion (GO:0032305)3.50746119
24nonmotile primary cilium assembly (GO:0035058)3.48981600
25reflex (GO:0060004)3.47876868
26photoreceptor cell maintenance (GO:0045494)3.42067619
27epithelial cilium movement (GO:0003351)3.40012709
28regulation of glucocorticoid secretion (GO:2000849)3.37206209
29G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.32300243
30negative regulation of telomere maintenance (GO:0032205)3.26189705
31detection of mechanical stimulus involved in sensory perception (GO:0050974)3.26114784
32gamma-aminobutyric acid transport (GO:0015812)3.18040226
33somite development (GO:0061053)3.18035989
34tryptophan metabolic process (GO:0006568)3.10596613
35protein K11-linked deubiquitination (GO:0035871)3.09460114
36neuronal action potential (GO:0019228)3.05900831
37regulation of translation, ncRNA-mediated (GO:0045974)3.01050035
38negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.01050035
39negative regulation of translation, ncRNA-mediated (GO:0040033)3.01050035
40photoreceptor cell development (GO:0042461)3.00068444
41cytokine biosynthetic process (GO:0042089)2.99488006
42phosphatidylcholine acyl-chain remodeling (GO:0036151)2.95190658
43cellular ketone body metabolic process (GO:0046950)2.94966400
44regulation of telomere maintenance (GO:0032204)2.93650499
45cilium movement (GO:0003341)2.93645908
46cilium or flagellum-dependent cell motility (GO:0001539)2.88074543
47ubiquinone biosynthetic process (GO:0006744)2.86984239
48metallo-sulfur cluster assembly (GO:0031163)2.80734253
49iron-sulfur cluster assembly (GO:0016226)2.80734253
50eye photoreceptor cell development (GO:0042462)2.79582882
51behavioral response to ethanol (GO:0048149)2.78945849
52phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.78564104
53multicellular organism reproduction (GO:0032504)2.76816997
54ketone body metabolic process (GO:1902224)2.76355837
55intestinal epithelial cell development (GO:0060576)2.74676685
56cellular biogenic amine catabolic process (GO:0042402)2.74073940
57amine catabolic process (GO:0009310)2.74073940
58inner ear receptor stereocilium organization (GO:0060122)2.73933186
59synaptic transmission, cholinergic (GO:0007271)2.72330980
60sulfation (GO:0051923)2.72047910
61anterograde synaptic vesicle transport (GO:0048490)2.71395810
62regulation of hippo signaling (GO:0035330)2.71245768
63thyroid hormone metabolic process (GO:0042403)2.71079098
64DNA deamination (GO:0045006)2.70473715
65benzene-containing compound metabolic process (GO:0042537)2.67516932
66L-fucose catabolic process (GO:0042355)2.65991409
67fucose catabolic process (GO:0019317)2.65991409
68L-fucose metabolic process (GO:0042354)2.65991409
69negative regulation of reactive oxygen species metabolic process (GO:2000378)2.62030437
70organic cation transport (GO:0015695)2.61289108
71inositol phosphate catabolic process (GO:0071545)2.59061843
72ubiquinone metabolic process (GO:0006743)2.58854106
73cAMP catabolic process (GO:0006198)2.57785395
74regulation of corticosteroid hormone secretion (GO:2000846)2.57018133
75axoneme assembly (GO:0035082)2.55994544
76detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.55191739
77auditory receptor cell stereocilium organization (GO:0060088)2.54283893
78response to misfolded protein (GO:0051788)2.54185139
79positive regulation of organic acid transport (GO:0032892)2.50235928
80detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.49569732
81regulation of appetite (GO:0032098)2.49082407
82piRNA metabolic process (GO:0034587)2.48626541
83S-adenosylmethionine metabolic process (GO:0046500)2.47885417
84cytokine metabolic process (GO:0042107)2.46862093
85regulation of non-canonical Wnt signaling pathway (GO:2000050)2.45953414
86detection of chemical stimulus involved in sensory perception (GO:0050907)2.45806613
87C4-dicarboxylate transport (GO:0015740)2.45738483
88response to pheromone (GO:0019236)2.45531169
89regulation of cardioblast proliferation (GO:0003264)2.44801093
90regulation of secondary heart field cardioblast proliferation (GO:0003266)2.44801093
91thyroid hormone generation (GO:0006590)2.44119159
92regulation of cilium movement (GO:0003352)2.44104055
93phosphorylated carbohydrate dephosphorylation (GO:0046838)2.42765012
94inositol phosphate dephosphorylation (GO:0046855)2.42765012
95cilium organization (GO:0044782)2.42176511
96positive regulation of defense response to virus by host (GO:0002230)2.41152964
97regulation of MHC class I biosynthetic process (GO:0045343)2.40922541
98cyclic nucleotide catabolic process (GO:0009214)2.40548108
99negative regulation of cytosolic calcium ion concentration (GO:0051481)2.40489691
100regulation of nuclear cell cycle DNA replication (GO:0033262)2.38596457

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.26693684
2VDR_22108803_ChIP-Seq_LS180_Human3.15043862
3EZH2_22144423_ChIP-Seq_EOC_Human2.93886453
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.83701410
5GBX2_23144817_ChIP-Seq_PC3_Human2.80725711
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.75471715
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.37125146
8IGF1R_20145208_ChIP-Seq_DFB_Human2.32090543
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.29583080
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.23395237
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.19272492
12ER_23166858_ChIP-Seq_MCF-7_Human2.12247298
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.10150475
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.05398187
15P300_19829295_ChIP-Seq_ESCs_Human2.03127941
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.01105819
17FUS_26573619_Chip-Seq_HEK293_Human1.95615010
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94837884
19* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.87461085
20TAF15_26573619_Chip-Seq_HEK293_Human1.86019089
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83988695
22BCAT_22108803_ChIP-Seq_LS180_Human1.83789454
23EWS_26573619_Chip-Seq_HEK293_Human1.81972004
24BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.81782816
25UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.79953608
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.77028262
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.74633211
28AR_25329375_ChIP-Seq_VCAP_Human1.67807284
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66259470
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.66047574
31CBP_20019798_ChIP-Seq_JUKART_Human1.65945973
32IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.65945973
33PIAS1_25552417_ChIP-Seq_VCAP_Human1.64418579
34SMAD4_21799915_ChIP-Seq_A2780_Human1.64288596
35NR3C1_21868756_ChIP-Seq_MCF10A_Human1.62550398
36STAT3_23295773_ChIP-Seq_U87_Human1.60375625
37TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59366475
38POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.59366475
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.56063600
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55566402
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.53887007
42GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.46357914
43TCF4_23295773_ChIP-Seq_U87_Human1.46312967
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45094411
45TCF4_22108803_ChIP-Seq_LS180_Human1.44867737
46RUNX2_22187159_ChIP-Seq_PCA_Human1.42695691
47TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41368245
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41046273
49PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40471419
50KLF5_20875108_ChIP-Seq_MESCs_Mouse1.40143825
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.40000080
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39285291
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36717885
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.34103433
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.31056459
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.30980221
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.30980221
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30278970
59PRDM14_20953172_ChIP-Seq_ESCs_Human1.30247791
60RNF2_27304074_Chip-Seq_NSC_Mouse1.27283146
61SMAD4_21741376_ChIP-Seq_EPCs_Human1.26602729
62FLI1_21867929_ChIP-Seq_TH2_Mouse1.24340269
63NANOG_19829295_ChIP-Seq_ESCs_Human1.22838845
64SOX2_19829295_ChIP-Seq_ESCs_Human1.22838845
65AR_21572438_ChIP-Seq_LNCaP_Human1.21780793
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21466569
67ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21346127
68REST_21632747_ChIP-Seq_MESCs_Mouse1.21112358
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.20329128
70BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19845366
71GATA3_21878914_ChIP-Seq_MCF-7_Human1.19217308
72FOXA1_21572438_ChIP-Seq_LNCaP_Human1.19121226
73ETV2_25802403_ChIP-Seq_MESCs_Mouse1.18568234
74TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18556189
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17429561
76RXR_22108803_ChIP-Seq_LS180_Human1.17058609
77CRX_20693478_ChIP-Seq_RETINA_Mouse1.16928705
78NCOR_22424771_ChIP-Seq_293T_Human1.16873693
79CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16807334
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16312939
81NANOG_18555785_Chip-Seq_ESCs_Mouse1.15827787
82TP53_22573176_ChIP-Seq_HFKS_Human1.14490372
83BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13845671
84P53_22387025_ChIP-Seq_ESCs_Mouse1.13750994
85HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.13388373
86CDX2_22108803_ChIP-Seq_LS180_Human1.09830116
87STAT3_18555785_Chip-Seq_ESCs_Mouse1.09641887
88IRF1_19129219_ChIP-ChIP_H3396_Human1.09575536
89RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08428171
90HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06030378
91ETV1_20927104_ChIP-Seq_GIST48_Human1.04461583
92DROSHA_22980978_ChIP-Seq_HELA_Human1.04244239
93* AR_20517297_ChIP-Seq_VCAP_Human1.02181708
94E2F1_18555785_Chip-Seq_ESCs_Mouse1.01574419
95SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.00647717
96AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00537361
97MYC_18940864_ChIP-ChIP_HL60_Human0.99662654
98HOXB7_26014856_ChIP-Seq_BT474_Human0.99243194
99PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99029398
100P300_18555785_Chip-Seq_ESCs_Mouse0.98823387

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology4.21430005
2MP0000569_abnormal_digit_pigmentation3.99432454
3MP0001968_abnormal_touch/_nociception3.79588681
4MP0003283_abnormal_digestive_organ3.49175116
5MP0005503_abnormal_tendon_morphology2.73242028
6MP0002736_abnormal_nociception_after2.62996321
7MP0005551_abnormal_eye_electrophysiolog2.52301368
8MP0008877_abnormal_DNA_methylation2.48532565
9MP0002254_reproductive_system_inflammat2.47769162
10MP0001501_abnormal_sleep_pattern2.39522943
11MP0003880_abnormal_central_pattern2.29034931
12MP0003646_muscle_fatigue2.16975882
13MP0006276_abnormal_autonomic_nervous2.06702121
14MP0003195_calcinosis1.99021275
15MP0009745_abnormal_behavioral_response1.97946187
16MP0005253_abnormal_eye_physiology1.92846013
17MP0009046_muscle_twitch1.89564490
18MP0010386_abnormal_urinary_bladder1.89329828
19MP0002638_abnormal_pupillary_reflex1.84692044
20MP0002909_abnormal_adrenal_gland1.78823811
21MP0005174_abnormal_tail_pigmentation1.76846963
22MP0006054_spinal_hemorrhage1.73620951
23MP0003950_abnormal_plasma_membrane1.67601104
24MP0002938_white_spotting1.61966887
25MP0005645_abnormal_hypothalamus_physiol1.61194315
26MP0003787_abnormal_imprinting1.59883440
27MP0000372_irregular_coat_pigmentation1.59005176
28MP0000427_abnormal_hair_cycle1.58337977
29MP0002272_abnormal_nervous_system1.54472016
30MP0002138_abnormal_hepatobiliary_system1.46066884
31MP0004142_abnormal_muscle_tone1.45078721
32MP0001486_abnormal_startle_reflex1.42520347
33MP0001905_abnormal_dopamine_level1.41340715
34MP0005083_abnormal_biliary_tract1.37280508
35MP0004924_abnormal_behavior1.36629183
36MP0005386_behavior/neurological_phenoty1.36629183
37MP0006072_abnormal_retinal_apoptosis1.34341286
38MP0005647_abnormal_sex_gland1.33729461
39MP0002876_abnormal_thyroid_physiology1.32827901
40MP0005646_abnormal_pituitary_gland1.32395727
41MP0002067_abnormal_sensory_capabilities1.29468049
42MP0000613_abnormal_salivary_gland1.27291497
43MP0004147_increased_porphyrin_level1.25218250
44MP0000538_abnormal_urinary_bladder1.24913594
45MP0002837_dystrophic_cardiac_calcinosis1.23640563
46MP0002557_abnormal_social/conspecific_i1.22634392
47MP0004134_abnormal_chest_morphology1.22108442
48MP0002282_abnormal_trachea_morphology1.18981485
49MP0005671_abnormal_response_to1.17659514
50MP0008875_abnormal_xenobiotic_pharmacok1.17253408
51MP0004742_abnormal_vestibular_system1.15918945
52MP0000631_abnormal_neuroendocrine_gland1.13788037
53MP0002064_seizures1.10597111
54MP0002572_abnormal_emotion/affect_behav1.08230543
55MP0005171_absent_coat_pigmentation1.07403961
56MP0008872_abnormal_physiological_respon1.07307610
57MP0001970_abnormal_pain_threshold1.05295508
58MP0000015_abnormal_ear_pigmentation1.03384284
59MP0000371_diluted_coat_color1.03226010
60MP0002735_abnormal_chemical_nociception1.00564163
61MP0002733_abnormal_thermal_nociception0.99637527
62MP0002108_abnormal_muscle_morphology0.98593887
63MP0002095_abnormal_skin_pigmentation0.96419305
64MP0001963_abnormal_hearing_physiology0.95671586
65MP0003698_abnormal_male_reproductive0.94416541
66MP0000639_abnormal_adrenal_gland0.93959045
67MP0005410_abnormal_fertilization0.92807823
68MP0008995_early_reproductive_senescence0.91104605
69MP0000516_abnormal_urinary_system0.90085688
70MP0005367_renal/urinary_system_phenotyp0.90085688
71MP0001986_abnormal_taste_sensitivity0.89645917
72MP0000026_abnormal_inner_ear0.88180859
73MP0004885_abnormal_endolymph0.87726992
74MP0003937_abnormal_limbs/digits/tail_de0.87126966
75MP0005389_reproductive_system_phenotype0.85793840
76MP0001984_abnormal_olfaction0.85112265
77MP0004043_abnormal_pH_regulation0.84441211
78MP0005508_abnormal_skeleton_morphology0.84374395
79MP0000383_abnormal_hair_follicle0.83629009
80MP0010329_abnormal_lipoprotein_level0.82619627
81MP0003252_abnormal_bile_duct0.82408408
82MP0002160_abnormal_reproductive_system0.82140500
83MP0002751_abnormal_autonomic_nervous0.81527573
84MP0002734_abnormal_mechanical_nocicepti0.80053664
85MP0000230_abnormal_systemic_arterial0.78302635
86MP0005075_abnormal_melanosome_morpholog0.77910754
87MP0003635_abnormal_synaptic_transmissio0.77729387
88MP0003718_maternal_effect0.77246828
89MP0002234_abnormal_pharynx_morphology0.76300362
90MP0002752_abnormal_somatic_nervous0.75823613
91MP0002229_neurodegeneration0.74778366
92MP0004883_abnormal_blood_vessel0.74769312
93MP0003137_abnormal_impulse_conducting0.72862208
94MP0005195_abnormal_posterior_eye0.72835894
95MP0009250_abnormal_appendicular_skeleto0.71859832
96MP0002063_abnormal_learning/memory/cond0.71607409
97MP0003136_yellow_coat_color0.70215400
98MP0001324_abnormal_eye_pigmentation0.69002585
99MP0005167_abnormal_blood-brain_barrier0.68708224
100MP0004133_heterotaxia0.67818818

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.55363298
2Molar tooth sign on MRI (HP:0002419)4.25694761
3Abnormality of midbrain morphology (HP:0002418)4.25694761
4Pancreatic fibrosis (HP:0100732)4.03932276
5Congenital stationary night blindness (HP:0007642)3.93511032
6True hermaphroditism (HP:0010459)3.54368560
7Polydipsia (HP:0001959)3.48248341
8Abnormal drinking behavior (HP:0030082)3.48248341
9Abnormality of the renal cortex (HP:0011035)3.48183904
10Tubular atrophy (HP:0000092)3.44440308
11Hyperventilation (HP:0002883)3.41801871
12Nephronophthisis (HP:0000090)3.36230988
13Fair hair (HP:0002286)3.18206190
14Abnormality of the renal medulla (HP:0100957)3.08445299
15Abnormal rod and cone electroretinograms (HP:0008323)3.07132630
16Gaze-evoked nystagmus (HP:0000640)3.00189770
17Attenuation of retinal blood vessels (HP:0007843)2.99423538
18Polyuria (HP:0000103)2.87031033
19Aplasia/Hypoplasia involving the musculature (HP:0001460)2.84050448
20Decreased central vision (HP:0007663)2.78595229
21Medial flaring of the eyebrow (HP:0010747)2.75972001
22Congenital, generalized hypertrichosis (HP:0004540)2.73301687
23Abnormality of the axillary hair (HP:0100134)2.73024509
24Abnormality of secondary sexual hair (HP:0009888)2.73024509
25Increased corneal curvature (HP:0100692)2.70852217
26Keratoconus (HP:0000563)2.70852217
27Generalized hypopigmentation of hair (HP:0011358)2.69004003
28Bile duct proliferation (HP:0001408)2.65858419
29Abnormal biliary tract physiology (HP:0012439)2.65858419
30Febrile seizures (HP:0002373)2.63826986
31Aplasia/Hypoplasia of the tibia (HP:0005772)2.62685074
32Hypoglycemic seizures (HP:0002173)2.57780423
33Stomach cancer (HP:0012126)2.47787091
34Cystic liver disease (HP:0006706)2.47387823
35Renal cortical cysts (HP:0000803)2.45699218
36Focal motor seizures (HP:0011153)2.44834754
37Absent rod-and cone-mediated responses on ERG (HP:0007688)2.43677505
38Small hand (HP:0200055)2.43653766
39Focal seizures (HP:0007359)2.43309103
40Inability to walk (HP:0002540)2.39986237
41Absent frontal sinuses (HP:0002688)2.33210242
42Type II lissencephaly (HP:0007260)2.32476576
43Hemiparesis (HP:0001269)2.30772063
44Progressive inability to walk (HP:0002505)2.30431346
45Abnormal urine output (HP:0012590)2.27393594
46Protruding tongue (HP:0010808)2.26702733
47Tubulointerstitial fibrosis (HP:0005576)2.26238881
48Aplasia of the musculature (HP:0100854)2.24727346
49Bifid tongue (HP:0010297)2.24357155
50Aplasia/Hypoplasia of the uvula (HP:0010293)2.20002091
51Intestinal atresia (HP:0011100)2.17290648
52Congenital hepatic fibrosis (HP:0002612)2.15671571
53Decreased circulating renin level (HP:0003351)2.14674060
54Bony spicule pigmentary retinopathy (HP:0007737)2.12493217
55Gait imbalance (HP:0002141)2.09359576
56Tubulointerstitial abnormality (HP:0001969)2.06426733
57Asplenia (HP:0001746)2.06109221
58Short tibia (HP:0005736)2.05074212
59Ulnar claw (HP:0001178)2.03699720
60Aplasia/Hypoplasia of the tongue (HP:0010295)2.03564768
61Aplasia/Hypoplasia of the spleen (HP:0010451)2.03381468
62Congenital primary aphakia (HP:0007707)1.99776704
63Dialeptic seizures (HP:0011146)1.97909199
64Atonic seizures (HP:0010819)1.96312548
65Hypoplastic ischia (HP:0003175)1.95522911
66Abnormality of renal excretion (HP:0011036)1.94153866
67Abnormal protein glycosylation (HP:0012346)1.92956230
68Abnormal glycosylation (HP:0012345)1.92956230
69Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.92956230
70Abnormal protein N-linked glycosylation (HP:0012347)1.92956230
71Hypothermia (HP:0002045)1.92687918
72Absent speech (HP:0001344)1.92002141
73Metaphyseal dysplasia (HP:0100255)1.89731677
74Dry hair (HP:0011359)1.89153150
75Sclerocornea (HP:0000647)1.88672614
76Anencephaly (HP:0002323)1.87835040
77Disproportionate short-trunk short stature (HP:0003521)1.85775930
78Oculomotor apraxia (HP:0000657)1.84146187
79Male pseudohermaphroditism (HP:0000037)1.83087893
80Pendular nystagmus (HP:0012043)1.82667302
81Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.81387865
82Postaxial foot polydactyly (HP:0001830)1.81257449
83Absent thumb (HP:0009777)1.80602745
84Elevated erythrocyte sedimentation rate (HP:0003565)1.78232730
85Abolished electroretinogram (ERG) (HP:0000550)1.77724457
86Chronic hepatic failure (HP:0100626)1.73079689
87Type I transferrin isoform profile (HP:0003642)1.72521803
88Enlarged kidneys (HP:0000105)1.71749265
89Genital tract atresia (HP:0001827)1.71562678
90Progressive cerebellar ataxia (HP:0002073)1.71213162
91Narrow forehead (HP:0000341)1.70699849
92Postaxial hand polydactyly (HP:0001162)1.70485331
93Severe muscular hypotonia (HP:0006829)1.68975373
94Absent/shortened dynein arms (HP:0200106)1.68520883
95Dynein arm defect of respiratory motile cilia (HP:0012255)1.68520883
96Generalized myoclonic seizures (HP:0002123)1.68007971
97Nephrogenic diabetes insipidus (HP:0009806)1.67169463
98Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.66602618
99Abnormality of the phalanges of the 2nd finger (HP:0009541)1.65938222
100Vaginal atresia (HP:0000148)1.65885510

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.33695304
2ADRBK23.52470129
3TLK12.87081514
4GRK12.66817166
5CASK2.64465518
6BMPR1B2.55029513
7WNK32.41206378
8MAPK132.40473429
9NUAK12.13966353
10MAP3K42.08797225
11TNIK1.95729862
12PINK11.87072562
13PDK21.84744953
14MST41.83943758
15FGFR21.75355388
16NTRK31.63809182
17ACVR1B1.61735849
18MAP4K21.46808452
19MKNK21.42587338
20PAK31.40993252
21AKT31.40081005
22ZAK1.39656057
23TAOK31.39626799
24TEC1.28694718
25STK391.27675332
26PTK2B1.27078175
27TXK1.25355464
28PLK21.23437806
29ADRBK11.23192243
30CLK11.21333732
31TNK21.14866260
32MAP2K71.14312898
33WNK41.12159036
34OXSR11.11176645
35ERBB21.07768889
36IRAK11.05576101
37INSRR1.01148303
38DYRK1A1.00441727
39EPHA40.98612488
40MARK30.96876777
41PRKCE0.94922390
42VRK10.90642707
43PRKCG0.87080299
44MARK10.81123319
45STK38L0.79971452
46MAPKAPK30.75316623
47PKN10.71418925
48CAMKK20.68378975
49PRKD20.67393503
50CSNK1G10.67082813
51PHKG10.66932081
52PHKG20.66932081
53TRIM280.65823795
54CAMK2A0.63897795
55DAPK20.62823066
56PNCK0.62369227
57JAK10.60893085
58FGFR30.60870308
59NTRK20.60781188
60PRKCI0.59544320
61ERBB30.59170785
62NLK0.57376574
63FER0.55631943
64ITK0.53299440
65NME10.51435765
66PIK3CA0.50510101
67PRKACA0.49625454
68TYK20.49302199
69PAK60.48207476
70CAMK1D0.47787082
71CAMK1G0.47176997
72CSNK1G20.45841296
73CSNK1A10.45596854
74IKBKB0.44722247
75RPS6KA50.43863669
76STK30.43063325
77BRSK20.42895978
78CSNK1D0.42496202
79ABL20.42348755
80PRKCQ0.42324708
81BMPR20.41503143
82BCR0.41235032
83SGK20.39767178
84CSNK1A1L0.39018327
85ABL10.35898431
86OBSCN0.35228009
87PRKCH0.33904781
88PRKCA0.33659483
89PRKAA10.33219253
90SRPK10.33086353
91CAMK10.32261413
92PRKAA20.32206903
93IKBKE0.30528591
94KIT0.30512769
95MAP2K60.30466109
96EGFR0.30044952
97STK110.29243362
98CSNK1G30.29098156
99TGFBR10.28744439
100PRKG10.27351309

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.75803891
2Linoleic acid metabolism_Homo sapiens_hsa005913.67166085
3Phototransduction_Homo sapiens_hsa047443.15458196
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.04547060
5Butanoate metabolism_Homo sapiens_hsa006502.81268898
6Nitrogen metabolism_Homo sapiens_hsa009102.57561536
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.52066680
8Ether lipid metabolism_Homo sapiens_hsa005652.28565941
9Olfactory transduction_Homo sapiens_hsa047402.09406286
10Nicotine addiction_Homo sapiens_hsa050332.02871444
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.93682846
12Taste transduction_Homo sapiens_hsa047421.89882683
13Propanoate metabolism_Homo sapiens_hsa006401.88200880
14Tryptophan metabolism_Homo sapiens_hsa003801.80778152
15Fat digestion and absorption_Homo sapiens_hsa049751.66385506
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.56334313
17Primary bile acid biosynthesis_Homo sapiens_hsa001201.49585317
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.48495789
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.48487210
20Homologous recombination_Homo sapiens_hsa034401.42565162
21Caffeine metabolism_Homo sapiens_hsa002321.42515237
22Protein export_Homo sapiens_hsa030601.40552621
23Fanconi anemia pathway_Homo sapiens_hsa034601.39136467
24Arachidonic acid metabolism_Homo sapiens_hsa005901.36019584
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.34469505
26Asthma_Homo sapiens_hsa053101.25851313
27Basal transcription factors_Homo sapiens_hsa030221.25280143
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.23868124
29Chemical carcinogenesis_Homo sapiens_hsa052041.22884775
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22101691
31Peroxisome_Homo sapiens_hsa041461.20530614
32Oxidative phosphorylation_Homo sapiens_hsa001901.19533694
33Morphine addiction_Homo sapiens_hsa050321.16363860
34ABC transporters_Homo sapiens_hsa020101.14945164
35Collecting duct acid secretion_Homo sapiens_hsa049661.01125143
36Circadian rhythm_Homo sapiens_hsa047101.00113222
37Allograft rejection_Homo sapiens_hsa053300.99689820
38Dorso-ventral axis formation_Homo sapiens_hsa043200.97799784
39Intestinal immune network for IgA production_Homo sapiens_hsa046720.96886416
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.96158077
41African trypanosomiasis_Homo sapiens_hsa051430.88983037
42Regulation of autophagy_Homo sapiens_hsa041400.87236330
43Type I diabetes mellitus_Homo sapiens_hsa049400.87199900
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.85876776
45Glutamatergic synapse_Homo sapiens_hsa047240.83666001
46Retinol metabolism_Homo sapiens_hsa008300.83511858
47Primary immunodeficiency_Homo sapiens_hsa053400.81042824
48Mineral absorption_Homo sapiens_hsa049780.80010666
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.79842556
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79385990
51Serotonergic synapse_Homo sapiens_hsa047260.79364541
52Ovarian steroidogenesis_Homo sapiens_hsa049130.76337791
53Selenocompound metabolism_Homo sapiens_hsa004500.75102957
54Insulin secretion_Homo sapiens_hsa049110.73577009
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73258016
56RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.72824869
57Circadian entrainment_Homo sapiens_hsa047130.72065937
58Glycerolipid metabolism_Homo sapiens_hsa005610.71679321
59Salivary secretion_Homo sapiens_hsa049700.71225915
60Sulfur relay system_Homo sapiens_hsa041220.70103789
61RNA polymerase_Homo sapiens_hsa030200.69967681
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69355440
63Parkinsons disease_Homo sapiens_hsa050120.68915489
64Glycerophospholipid metabolism_Homo sapiens_hsa005640.67849101
65Calcium signaling pathway_Homo sapiens_hsa040200.67759805
66One carbon pool by folate_Homo sapiens_hsa006700.67572851
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67453963
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66986560
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66658974
70RNA degradation_Homo sapiens_hsa030180.64942640
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.64917697
72beta-Alanine metabolism_Homo sapiens_hsa004100.63219135
73Graft-versus-host disease_Homo sapiens_hsa053320.63189795
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62509103
75Proteasome_Homo sapiens_hsa030500.61871465
76Autoimmune thyroid disease_Homo sapiens_hsa053200.61710211
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60425937
78Cardiac muscle contraction_Homo sapiens_hsa042600.58970199
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56947350
80Non-homologous end-joining_Homo sapiens_hsa034500.56083108
81Dopaminergic synapse_Homo sapiens_hsa047280.52425782
82Glutathione metabolism_Homo sapiens_hsa004800.50896992
83Sphingolipid metabolism_Homo sapiens_hsa006000.48984555
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.46628380
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46320184
86Rheumatoid arthritis_Homo sapiens_hsa053230.44523880
87Metabolic pathways_Homo sapiens_hsa011000.43033292
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.42570155
89Jak-STAT signaling pathway_Homo sapiens_hsa046300.40472395
90Alzheimers disease_Homo sapiens_hsa050100.39229671
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39177705
92Steroid biosynthesis_Homo sapiens_hsa001000.39153261
93GABAergic synapse_Homo sapiens_hsa047270.36798535
94Cocaine addiction_Homo sapiens_hsa050300.36617502
95Pancreatic secretion_Homo sapiens_hsa049720.36511514
96Arginine and proline metabolism_Homo sapiens_hsa003300.36402423
97Huntingtons disease_Homo sapiens_hsa050160.34796516
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34719204
99Fatty acid metabolism_Homo sapiens_hsa012120.34623048
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.34570929

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