KLHL4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the kelch family of proteins, which are characterized by kelch repeat motifs and a POZ/BTB protein-binding domain. It is thought that kelch repeats are actin binding domains. However, the specific function of this protein has not been determined. Alternative splicing of this gene results in two transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)7.92278150
2myelination (GO:0042552)6.61492623
3axon ensheathment (GO:0008366)6.60998626
4ensheathment of neurons (GO:0007272)6.60998626
5long-chain fatty acid biosynthetic process (GO:0042759)6.27736181
6myelin maintenance (GO:0043217)5.69721920
7negative regulation of neurotransmitter transport (GO:0051589)5.23681114
8negative regulation of neurotransmitter secretion (GO:0046929)5.10797028
9establishment of mitochondrion localization (GO:0051654)4.89165862
10negative regulation of protein localization to cell surface (GO:2000009)4.71231485
11cholesterol biosynthetic process (GO:0006695)4.64161306
12lipopolysaccharide biosynthetic process (GO:0009103)4.61924941
13establishment of integrated proviral latency (GO:0075713)4.58231299
14glucocorticoid biosynthetic process (GO:0006704)4.39325519
15response to methylmercury (GO:0051597)4.34536571
16regulation of collateral sprouting (GO:0048670)4.27520237
17C4-dicarboxylate transport (GO:0015740)4.20415915
18creatine metabolic process (GO:0006600)4.17017204
19sterol biosynthetic process (GO:0016126)4.15222316
20apical protein localization (GO:0045176)4.14572790
21amyloid precursor protein metabolic process (GO:0042982)4.12223344
22presynaptic membrane organization (GO:0097090)4.01353917
23L-amino acid import (GO:0043092)4.00533825
24positive regulation of oligodendrocyte differentiation (GO:0048714)3.94322073
25peptidyl-tyrosine autophosphorylation (GO:0038083)3.93379901
26oligodendrocyte differentiation (GO:0048709)3.91951468
27long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.91540596
28long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.83534107
29regulation of lipoprotein metabolic process (GO:0050746)3.81903230
30neuron remodeling (GO:0016322)3.78672493
31photoreceptor cell differentiation (GO:0046530)3.76240750
32eye photoreceptor cell differentiation (GO:0001754)3.76240750
33astrocyte development (GO:0014002)3.74219055
34isoprenoid biosynthetic process (GO:0008299)3.73587292
35asymmetric protein localization (GO:0008105)3.72519970
36glycerophospholipid catabolic process (GO:0046475)3.65950306
37lipopolysaccharide metabolic process (GO:0008653)3.65117460
38membrane tubulation (GO:0097320)3.57580655
39establishment of viral latency (GO:0019043)3.55597227
40regulation of cardiac muscle cell contraction (GO:0086004)3.55284071
41regulation of transforming growth factor beta2 production (GO:0032909)3.48399131
42DNA strand renaturation (GO:0000733)3.47147410
43protein neddylation (GO:0045116)3.46848769
44response to lipoprotein particle (GO:0055094)3.46586915
45presynaptic membrane assembly (GO:0097105)3.46344370
46postsynaptic membrane organization (GO:0001941)3.44879282
47import into cell (GO:0098657)3.40946863
48fatty-acyl-CoA metabolic process (GO:0035337)3.37441846
49fatty-acyl-CoA biosynthetic process (GO:0046949)3.37261152
50adult walking behavior (GO:0007628)3.34159263
51neurotransmitter uptake (GO:0001504)3.31022287
52proteasome assembly (GO:0043248)3.29693704
53cullin deneddylation (GO:0010388)3.28730533
54substantia nigra development (GO:0021762)3.27889761
55negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.27625456
56protein deneddylation (GO:0000338)3.27472689
57protein palmitoylation (GO:0018345)3.24935288
58heme transport (GO:0015886)3.12955556
59protein heterotetramerization (GO:0051290)3.11849050
60axon development (GO:0061564)3.07609928
61DNA double-strand break processing (GO:0000729)3.06782577
62nerve growth factor signaling pathway (GO:0038180)3.05230064
63negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.04372978
64retina vasculature morphogenesis in camera-type eye (GO:0061299)3.03096238
65lymphangiogenesis (GO:0001946)3.02195946
66iron coordination entity transport (GO:1901678)3.01497108
67very long-chain fatty acid metabolic process (GO:0000038)3.01381910
68negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.00092177
69magnesium ion transport (GO:0015693)2.99931401
70glucocorticoid metabolic process (GO:0008211)2.99638758
71androgen biosynthetic process (GO:0006702)2.97446857
72alpha-linolenic acid metabolic process (GO:0036109)2.97130311
73neuron cell-cell adhesion (GO:0007158)2.96986068
74cerebral cortex radially oriented cell migration (GO:0021799)2.96035268
75glycosylceramide metabolic process (GO:0006677)2.95981632
76estrogen biosynthetic process (GO:0006703)2.95530743
77auditory behavior (GO:0031223)2.94512991
78mitotic metaphase plate congression (GO:0007080)2.93687204
79myelination in peripheral nervous system (GO:0022011)2.93115197
80peripheral nervous system axon ensheathment (GO:0032292)2.93115197
81response to redox state (GO:0051775)2.90994556
82regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.90481347
83peptidyl-cysteine modification (GO:0018198)2.89912651
84ovulation cycle (GO:0042698)2.89480709
85hyperosmotic salinity response (GO:0042538)2.87737509
86neuronal action potential propagation (GO:0019227)2.85591791
87GPI anchor biosynthetic process (GO:0006506)2.83937605
88facial nerve structural organization (GO:0021612)2.82986015
89amino acid import (GO:0043090)2.82928693
90metaphase plate congression (GO:0051310)2.82707665
91positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.81546570
92gap junction assembly (GO:0016264)2.81087596
93L-serine metabolic process (GO:0006563)2.80833337
94preassembly of GPI anchor in ER membrane (GO:0016254)2.80293750
95thioester biosynthetic process (GO:0035384)2.77945406
96acyl-CoA biosynthetic process (GO:0071616)2.77945406
97negative regulation of axonogenesis (GO:0050771)2.77657344
98negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.76916831
99negative regulation of ligase activity (GO:0051352)2.76916831
100regulation of cardioblast differentiation (GO:0051890)2.72402217
101anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.72388684
102GPI anchor metabolic process (GO:0006505)2.71716534
103signal peptide processing (GO:0006465)2.71159744
104negative regulation of execution phase of apoptosis (GO:1900118)2.70436939
105vascular smooth muscle contraction (GO:0014829)2.70277253
106regulation of somitogenesis (GO:0014807)2.69955368
107enteric nervous system development (GO:0048484)2.68780667
108negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.68643925
109positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.68060487
110regulation of actin filament-based movement (GO:1903115)2.67006117
111cyclic nucleotide catabolic process (GO:0009214)2.66737454
112regulation of axon extension involved in axon guidance (GO:0048841)2.65906392
113chaperone-mediated protein transport (GO:0072321)2.65831430
114response to leptin (GO:0044321)2.64116948
115lactate metabolic process (GO:0006089)2.63355575
116anterior/posterior axis specification, embryo (GO:0008595)2.63213520
117cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.63058719
118negative regulation of cytosolic calcium ion concentration (GO:0051481)2.62496195
119amyloid precursor protein catabolic process (GO:0042987)2.61622354
120regulation of double-strand break repair via homologous recombination (GO:0010569)2.61013375
121mechanosensory behavior (GO:0007638)2.59985505
122cell communication by electrical coupling (GO:0010644)2.59798810
123detection of temperature stimulus involved in sensory perception (GO:0050961)2.59429302
124detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.59429302
125branched-chain amino acid catabolic process (GO:0009083)2.58953682
126chromatin remodeling at centromere (GO:0031055)2.57472395
127negative regulation of acute inflammatory response (GO:0002674)2.57446033
128positive regulation of male gonad development (GO:2000020)2.57395520
129tissue regeneration (GO:0042246)2.57099364
130cranial nerve structural organization (GO:0021604)2.56909943
131regulation of interleukin-13 production (GO:0032656)2.56220447
132positive regulation of pseudopodium assembly (GO:0031274)2.56030730
133positive regulation of glial cell differentiation (GO:0045687)2.55753057
134CENP-A containing nucleosome assembly (GO:0034080)2.55477308
135protein localization to kinetochore (GO:0034501)2.55364165
136nucleotide transmembrane transport (GO:1901679)2.54655987
137non-recombinational repair (GO:0000726)2.54115710
138double-strand break repair via nonhomologous end joining (GO:0006303)2.54115710
139regulation of cellular amino acid metabolic process (GO:0006521)2.50889454
140negative regulation of DNA recombination (GO:0045910)2.50866800
141neuron recognition (GO:0008038)2.50834508
142limb bud formation (GO:0060174)2.50287775
143atrial cardiac muscle cell action potential (GO:0086014)2.49752749
144regulation of pigment cell differentiation (GO:0050932)2.49580376
145digestive tract morphogenesis (GO:0048546)2.49310124
146cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.49125296
147organ growth (GO:0035265)2.48749609
148glycine transport (GO:0015816)2.48408594
149microtubule polymerization or depolymerization (GO:0031109)2.48281995
150leukocyte migration involved in inflammatory response (GO:0002523)2.45438895
151branch elongation of an epithelium (GO:0060602)2.45257151
152DNA replication-dependent nucleosome organization (GO:0034723)2.43548967
153DNA replication-dependent nucleosome assembly (GO:0006335)2.43548967
154negative regulation of synaptic transmission, GABAergic (GO:0032229)2.43339151
155ganglion development (GO:0061548)2.43191913
156response to monoamine (GO:0071867)2.42595570
157response to catecholamine (GO:0071869)2.42595570
158cellular response to catecholamine stimulus (GO:0071870)2.42503938
159cellular response to monoamine stimulus (GO:0071868)2.42503938
160regulation of cilium movement (GO:0003352)2.42436621
161positive regulation of gliogenesis (GO:0014015)2.42258170
162positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.42081203
163histone exchange (GO:0043486)2.41699270
164artery smooth muscle contraction (GO:0014824)2.41048698
165substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.40760079
166substrate-independent telencephalic tangential migration (GO:0021826)2.40760079
167adult locomotory behavior (GO:0008344)2.40226096
168response to epinephrine (GO:0071871)2.38695582
169regulation of coenzyme metabolic process (GO:0051196)2.33651271
170regulation of cofactor metabolic process (GO:0051193)2.33651271
171regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.33076039
172DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.31615794
173membrane assembly (GO:0071709)2.30937008
174regulation of skeletal muscle cell differentiation (GO:2001014)2.30910730
175female gonad development (GO:0008585)2.29713144
176cell migration involved in gastrulation (GO:0042074)2.28867671
177anatomical structure arrangement (GO:0048532)2.28388036
178respiratory tube development (GO:0030323)2.28187107
179regulation of cell communication by electrical coupling (GO:0010649)2.28129588
180signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.28010938
181intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.28010938
182positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.27404323
183signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.27262511
184signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.27262511
185signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.27262511
186negative regulation of axon extension involved in axon guidance (GO:0048843)2.26024694
187cellular response to leptin stimulus (GO:0044320)2.21198589
188axon ensheathment in central nervous system (GO:0032291)12.1426419
189central nervous system myelination (GO:0022010)12.1426419

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.42171162
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.81778729
3EZH2_22144423_ChIP-Seq_EOC_Human2.66906879
4SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.63035866
5TAF15_26573619_Chip-Seq_HEK293_Human2.56665303
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.51084997
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.48673143
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.47506689
9* POU5F1_16153702_ChIP-ChIP_HESCs_Human2.33821908
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.30821856
11ELK1_19687146_ChIP-ChIP_HELA_Human2.25732494
12OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.25149328
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.23227558
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.21757606
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.21032564
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.19173093
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.18938427
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.09467912
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.04912336
20RNF2_18974828_ChIP-Seq_MESCs_Mouse2.00706690
21EZH2_18974828_ChIP-Seq_MESCs_Mouse2.00706690
22EED_16625203_ChIP-ChIP_MESCs_Mouse1.99022964
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.98199148
24EZH2_27304074_Chip-Seq_ESCs_Mouse1.97791374
25NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.97034346
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.96886369
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.91507748
28E2F4_17652178_ChIP-ChIP_JURKAT_Human1.88145415
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.83983196
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.83500150
31SUZ12_27294783_Chip-Seq_ESCs_Mouse1.79675927
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.77269804
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.76849005
34AR_21572438_ChIP-Seq_LNCaP_Human1.74195715
35JARID2_20075857_ChIP-Seq_MESCs_Mouse1.71929532
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.68460729
37ER_23166858_ChIP-Seq_MCF-7_Human1.65000204
38RNF2_27304074_Chip-Seq_ESCs_Mouse1.64839253
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63739505
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.63416782
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61485414
42SOX2_16153702_ChIP-ChIP_HESCs_Human1.59505020
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59461012
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.57891675
45KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.57660834
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.57371422
47DROSHA_22980978_ChIP-Seq_HELA_Human1.56632979
48* NANOG_16153702_ChIP-ChIP_HESCs_Human1.55467728
49* SMAD3_21741376_ChIP-Seq_EPCs_Human1.51786184
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.50366642
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.45670847
52FUS_26573619_Chip-Seq_HEK293_Human1.45431111
53HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.43984620
54TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.43181957
55P300_19829295_ChIP-Seq_ESCs_Human1.42785818
56VDR_22108803_ChIP-Seq_LS180_Human1.41308980
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41027429
58STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.40928895
59PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38444339
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.37626809
61AR_21909140_ChIP-Seq_LNCAP_Human1.35882754
62PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35372638
63YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34526673
64NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.34488558
65SOX2_18555785_ChIP-Seq_MESCs_Mouse1.34325818
66NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.34318049
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32416851
68* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32375007
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31748169
70BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31336960
71E2F7_22180533_ChIP-Seq_HELA_Human1.29881468
72* SMAD3_21741376_ChIP-Seq_HESCs_Human1.26762182
73WT1_19549856_ChIP-ChIP_CCG9911_Human1.25539134
74CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.24934614
75EP300_21415370_ChIP-Seq_HL-1_Mouse1.24430063
76FLI1_27457419_Chip-Seq_LIVER_Mouse1.23911666
77LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22662738
78POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22387967
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21368704
80PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.19586854
81SOX9_26525672_Chip-Seq_HEART_Mouse1.19562341
82P53_22127205_ChIP-Seq_FIBROBLAST_Human1.18525977
83GATA2_21666600_ChIP-Seq_HMVEC_Human1.18458578
84GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17788276
85CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.17447165
86KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.16931294
87HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16863864
88* TAL1_26923725_Chip-Seq_HPCs_Mouse1.16490774
89MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.16442143
90NANOG_18555785_ChIP-Seq_MESCs_Mouse1.15992912
91PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15282969
92FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.14670212
93RARB_27405468_Chip-Seq_BRAIN_Mouse1.14450093
94CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14134722
95STAT3_23295773_ChIP-Seq_U87_Human1.13906539
96GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.13131684
97UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11713772
98EOMES_21245162_ChIP-Seq_HESCs_Human1.10991236
99SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.10824388
100SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.10355659
101TBX3_20139965_ChIP-Seq_ESCs_Mouse1.09889201
102NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09730080
103NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09730080
104TBX3_20139965_ChIP-Seq_MESCs_Mouse1.09469202
105JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.08981162
106TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08525300
107PRDM14_20953172_ChIP-Seq_ESCs_Human1.08379972
108LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08344766
109* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07891988
110NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07061210
111AR_25329375_ChIP-Seq_VCAP_Human1.06868696
112REST_21632747_ChIP-Seq_MESCs_Mouse1.06408691
113SMAD4_21741376_ChIP-Seq_HESCs_Human1.06012738
114E2F1_18555785_ChIP-Seq_MESCs_Mouse1.05468472
115SMAD_19615063_ChIP-ChIP_OVARY_Human1.05374273
116SMAD4_21799915_ChIP-Seq_A2780_Human1.05356718
117NELFA_20434984_ChIP-Seq_ESCs_Mouse1.04704287
118MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04546142
119SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.03845569
120CMYC_18555785_Chip-Seq_ESCs_Mouse1.03838563
121EWS_26573619_Chip-Seq_HEK293_Human1.03727037
122POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03642851
123TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03642851
124RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03378741
125HTT_18923047_ChIP-ChIP_STHdh_Human1.03231817
126ELK1_22589737_ChIP-Seq_MCF10A_Human1.02855727
127* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02765576
128GATA1_26923725_Chip-Seq_HPCs_Mouse1.02706776
129WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02380099
130PCGF2_27294783_Chip-Seq_ESCs_Mouse1.02084213
131AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01609534
132CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01601560
133NANOG_18555785_Chip-Seq_ESCs_Mouse1.01045006
134ETS1_20019798_ChIP-Seq_JURKAT_Human1.00599282
135SOX17_20123909_ChIP-Seq_XEN_Mouse1.00537440
136RNF2_27304074_Chip-Seq_NSC_Mouse0.99809749
137EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99685163
138NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.99535931
139* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99212985
140TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98978610
141TCF4_23295773_ChIP-Seq_U87_Human0.98173023
142TP53_16413492_ChIP-PET_HCT116_Human0.97790755
143P300_18555785_Chip-Seq_ESCs_Mouse0.97190794
144SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96352401
145TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94544702
146SMAD4_21741376_ChIP-Seq_EPCs_Human0.94195086
147ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92912539
148NR3C1_23031785_ChIP-Seq_PC12_Mouse0.92324597
149MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91940418
150ZNF274_21170338_ChIP-Seq_K562_Hela0.91770382
151SOX2_19829295_ChIP-Seq_ESCs_Human0.90653391
152NANOG_19829295_ChIP-Seq_ESCs_Human0.90653391
153SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.90094551
154GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.89838400
155EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89552500
156IGF1R_20145208_ChIP-Seq_DFB_Human0.89023416
157TRIM28_21343339_ChIP-Seq_HEK293_Human0.88819275

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.30719535
2MP0003880_abnormal_central_pattern3.96317898
3MP0003950_abnormal_plasma_membrane3.64968785
4MP0004270_analgesia3.37897118
5MP0005409_darkened_coat_color3.01072416
6MP0005171_absent_coat_pigmentation3.00813217
7MP0003690_abnormal_glial_cell2.83019136
8MP0001984_abnormal_olfaction2.82886595
9MP0001529_abnormal_vocalization2.71652363
10MP0002272_abnormal_nervous_system2.58604003
11MP0006054_spinal_hemorrhage2.56200690
12MP0001905_abnormal_dopamine_level2.54792247
13MP0008004_abnormal_stomach_pH2.42812544
14MP0003329_amyloid_beta_deposits2.39298936
15MP0001486_abnormal_startle_reflex2.37826740
16MP0004859_abnormal_synaptic_plasticity2.34008813
17MP0002064_seizures2.29946043
18MP0004885_abnormal_endolymph2.25906575
19MP0004142_abnormal_muscle_tone2.25556679
20MP0003890_abnormal_embryonic-extraembry2.20308587
21MP0004147_increased_porphyrin_level2.16397773
22MP0003634_abnormal_glial_cell2.04692826
23MP0004742_abnormal_vestibular_system2.03907118
24MP0008058_abnormal_DNA_repair2.00844673
25MP0003941_abnormal_skin_development1.99429900
26MP0003635_abnormal_synaptic_transmissio1.98830498
27MP0005423_abnormal_somatic_nervous1.96565855
28MP0009046_muscle_twitch1.93621907
29MP0000778_abnormal_nervous_system1.92192605
30MP0003119_abnormal_digestive_system1.85436908
31MP0009053_abnormal_anal_canal1.84277565
32MP0009745_abnormal_behavioral_response1.81813627
33MP0003632_abnormal_nervous_system1.79876208
34MP0003136_yellow_coat_color1.77753143
35MP0004134_abnormal_chest_morphology1.73530314
36MP0002229_neurodegeneration1.72990408
37MP0003631_nervous_system_phenotype1.68834075
38MP0002734_abnormal_mechanical_nocicepti1.68221649
39MP0004215_abnormal_myocardial_fiber1.66693286
40MP0001485_abnormal_pinna_reflex1.63915589
41MP0005410_abnormal_fertilization1.63600861
42MP0010678_abnormal_skin_adnexa1.63599741
43MP0003633_abnormal_nervous_system1.61186106
44MP0005623_abnormal_meninges_morphology1.58776491
45MP0004084_abnormal_cardiac_muscle1.54656113
46MP0002254_reproductive_system_inflammat1.53633832
47MP0008932_abnormal_embryonic_tissue1.51796616
48MP0001293_anophthalmia1.49955200
49MP0004145_abnormal_muscle_electrophysio1.49206991
50MP0004957_abnormal_blastocyst_morpholog1.49191974
51MP0009250_abnormal_appendicular_skeleto1.46998517
52MP0008007_abnormal_cellular_replicative1.45158437
53MP0008775_abnormal_heart_ventricle1.45013990
54MP0005167_abnormal_blood-brain_barrier1.44986046
55MP0003385_abnormal_body_wall1.44554460
56MP0000751_myopathy1.44470620
57MP0002063_abnormal_learning/memory/cond1.42321464
58MP0002572_abnormal_emotion/affect_behav1.41659858
59MP0004233_abnormal_muscle_weight1.41329341
60MP0008569_lethality_at_weaning1.39653809
61MP0004043_abnormal_pH_regulation1.37421088
62MP0003718_maternal_effect1.35293328
63MP0004924_abnormal_behavior1.33783195
64MP0005386_behavior/neurological_phenoty1.33783195
65MP0000579_abnormal_nail_morphology1.33680858
66MP0000383_abnormal_hair_follicle1.33202845
67MP0000955_abnormal_spinal_cord1.33181997
68MP0005253_abnormal_eye_physiology1.32978129
69MP0010030_abnormal_orbit_morphology1.31784783
70MP0002067_abnormal_sensory_capabilities1.31248100
71MP0003937_abnormal_limbs/digits/tail_de1.30969087
72MP0002233_abnormal_nose_morphology1.30155079
73MP0006276_abnormal_autonomic_nervous1.29897588
74MP0005499_abnormal_olfactory_system1.29510917
75MP0005394_taste/olfaction_phenotype1.29510917
76MP0001440_abnormal_grooming_behavior1.27148075
77MP0001970_abnormal_pain_threshold1.25945077
78MP0003806_abnormal_nucleotide_metabolis1.25865837
79MP0010094_abnormal_chromosome_stability1.25826410
80MP0002882_abnormal_neuron_morphology1.25488744
81MP0002066_abnormal_motor_capabilities/c1.24562446
82MP0005551_abnormal_eye_electrophysiolog1.22632853
83MP0008877_abnormal_DNA_methylation1.22448053
84MP0006072_abnormal_retinal_apoptosis1.22061002
85MP0001968_abnormal_touch/_nociception1.22027358
86MP0009379_abnormal_foot_pigmentation1.20124204
87MP0009384_cardiac_valve_regurgitation1.18598383
88MP0003011_delayed_dark_adaptation1.15314002
89MP0002736_abnormal_nociception_after1.14878960
90MP0004036_abnormal_muscle_relaxation1.14688134
91MP0004272_abnormal_basement_membrane1.14103144
92MP0002102_abnormal_ear_morphology1.13797106
93MP0008789_abnormal_olfactory_epithelium1.13465457
94MP0004133_heterotaxia1.11176874
95MP0001348_abnormal_lacrimal_gland1.10955898
96MP0000462_abnormal_digestive_system1.10421914
97MP0001915_intracranial_hemorrhage1.09283885
98MP0002822_catalepsy1.08634610
99MP0002084_abnormal_developmental_patter1.08572523
100MP0002697_abnormal_eye_size1.06305826
101MP0000747_muscle_weakness1.05269846
102MP0003567_abnormal_fetal_cardiomyocyte1.04852287
103MP0004381_abnormal_hair_follicle1.04715449
104MP0002733_abnormal_thermal_nociception1.04081517
105MP0001963_abnormal_hearing_physiology1.03056004
106MP0002752_abnormal_somatic_nervous1.01118577
107MP0010368_abnormal_lymphatic_system1.00569998
108MP0000604_amyloidosis0.99770598
109MP0001851_eye_inflammation0.98510752
110MP0003122_maternal_imprinting0.97582376
111MP0008260_abnormal_autophagy0.96774590
112MP0002332_abnormal_exercise_endurance0.96530939
113MP0000049_abnormal_middle_ear0.95626388
114MP0000749_muscle_degeneration0.92766070
115MP0003755_abnormal_palate_morphology0.92727307
116MP0001188_hyperpigmentation0.92457604
117MP0005195_abnormal_posterior_eye0.91212136
118MP0000516_abnormal_urinary_system0.89244290
119MP0005367_renal/urinary_system_phenotyp0.89244290
120MP0005451_abnormal_body_composition0.88798175
121MP0005391_vision/eye_phenotype0.88352336
122MP0005187_abnormal_penis_morphology0.87976566
123MP0005380_embryogenesis_phenotype0.86895367
124MP0001672_abnormal_embryogenesis/_devel0.86895367
125MP0005197_abnormal_uvea_morphology0.86747789
126MP0001879_abnormal_lymphatic_vessel0.83265007
127MP0000428_abnormal_craniofacial_morphol0.82918439
128MP0002295_abnormal_pulmonary_circulatio0.82750401
129MP0002085_abnormal_embryonic_tissue0.82295191
130MP0004085_abnormal_heartbeat0.82290025
131MP0001299_abnormal_eye_distance/0.82240157
132MP0003935_abnormal_craniofacial_develop0.82166298
133MP0002735_abnormal_chemical_nociception0.79838003
134MP0002938_white_spotting0.79616460
135MP0002088_abnormal_embryonic_growth/wei0.79450529
136MP0003566_abnormal_cell_adhesion0.78884839
137MP0009697_abnormal_copulation0.78881641
138MP0003861_abnormal_nervous_system0.78649294
139MP0002090_abnormal_vision0.78315114
140MP0006035_abnormal_mitochondrial_morpho0.78218161
141MP0002184_abnormal_innervation0.78106697
142MP0002152_abnormal_brain_morphology0.77978530
143MP0003121_genomic_imprinting0.77247499
144MP0001502_abnormal_circadian_rhythm0.77156851
145MP0002751_abnormal_autonomic_nervous0.76898209
146MP0003984_embryonic_growth_retardation0.76817566
147MP0005646_abnormal_pituitary_gland0.76135753
148MP0001730_embryonic_growth_arrest0.75804156
149MP0001286_abnormal_eye_development0.75648485
150MP0002111_abnormal_tail_morphology0.73845228
151MP0001346_abnormal_lacrimal_gland0.73611904
152MP0000465_gastrointestinal_hemorrhage0.72915848
153MP0006082_CNS_inflammation0.70961018
154MP0000647_abnormal_sebaceous_gland0.70022182
155MP0001501_abnormal_sleep_pattern0.70001941
156MP0002557_abnormal_social/conspecific_i0.69666136
157MP0001177_atelectasis0.69654132
158MP0004811_abnormal_neuron_physiology0.67931790
159MP0003938_abnormal_ear_development0.67899143
160MP0005058_abnormal_lysosome_morphology0.66291963
161MP0000566_synostosis0.65543020
162MP0003137_abnormal_impulse_conducting0.65147860
163MP0005408_hypopigmentation0.61981185
164MP0000762_abnormal_tongue_morphology0.61808725
165MP0000639_abnormal_adrenal_gland0.61506843
166MP0003195_calcinosis0.60668248

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)6.46648928
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.46648928
3Neurofibrillary tangles (HP:0002185)5.94127695
4Abnormality of the corticospinal tract (HP:0002492)4.92061614
5Peripheral hypomyelination (HP:0007182)4.47898002
6Parakeratosis (HP:0001036)4.38169369
7Cerebral inclusion bodies (HP:0100314)4.24880430
8Cerebral hypomyelination (HP:0006808)4.12096543
9Onion bulb formation (HP:0003383)4.06610623
10Stenosis of the external auditory canal (HP:0000402)3.91649995
11Termporal pattern (HP:0011008)3.84114321
12Insidious onset (HP:0003587)3.84114321
13Sensory axonal neuropathy (HP:0003390)3.80720247
14Spastic gait (HP:0002064)3.59395273
15Ankle clonus (HP:0011448)3.58204059
16Supranuclear gaze palsy (HP:0000605)3.57539406
17Scanning speech (HP:0002168)3.48059217
18Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.36110167
19Intention tremor (HP:0002080)3.35863880
20Abnormal auditory evoked potentials (HP:0006958)3.35451836
21Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.34622618
22Myokymia (HP:0002411)3.29411925
23Leukodystrophy (HP:0002415)3.27330767
24Cortical dysplasia (HP:0002539)3.24786735
25Dysmetria (HP:0001310)3.22172123
26Large earlobe (HP:0009748)3.14937664
27Cerebral hemorrhage (HP:0001342)3.06686449
28Gonadotropin excess (HP:0000837)3.03630462
29Retinal dysplasia (HP:0007973)3.02620064
30Atonic seizures (HP:0010819)3.01625672
31Focal motor seizures (HP:0011153)3.00612523
32Autoamputation (HP:0001218)3.00064947
33Pheochromocytoma (HP:0002666)2.94639317
34Segmental peripheral demyelination/remyelination (HP:0003481)2.88474498
35Cupped ear (HP:0000378)2.87194407
36Patchy hypopigmentation of hair (HP:0011365)2.83517337
37Abnormality of glycolysis (HP:0004366)2.80812427
38Increased serum pyruvate (HP:0003542)2.80812427
39Anomalous pulmonary venous return (HP:0010772)2.80113997
40Hemiplegia (HP:0002301)2.79700565
41CNS hypomyelination (HP:0003429)2.78857708
42Clumsiness (HP:0002312)2.66452462
43Vaginal atresia (HP:0000148)2.65881844
44Congenital primary aphakia (HP:0007707)2.64872528
45Slow saccadic eye movements (HP:0000514)2.64345274
46Gait imbalance (HP:0002141)2.63195761
47Anteriorly placed anus (HP:0001545)2.60004373
48Colon cancer (HP:0003003)2.58124890
49Genital tract atresia (HP:0001827)2.58005873
50Nephrogenic diabetes insipidus (HP:0009806)2.56375382
51Ependymoma (HP:0002888)2.56186019
52Neuroendocrine neoplasm (HP:0100634)2.52197122
53Alacrima (HP:0000522)2.50615727
54Hypoplasia of the iris (HP:0007676)2.49718023
55Spastic diplegia (HP:0001264)2.46141852
56Medial flaring of the eyebrow (HP:0010747)2.42678656
57Spastic paraparesis (HP:0002313)2.41345374
58Abnormality of the pulmonary veins (HP:0011718)2.38653868
59Congenital ichthyosiform erythroderma (HP:0007431)2.36378047
60Thickened helices (HP:0000391)2.35372696
61Clonus (HP:0002169)2.34251242
62Stridor (HP:0010307)2.32043071
63White forelock (HP:0002211)2.28962750
64Broad foot (HP:0001769)2.28702797
65Absent septum pellucidum (HP:0001331)2.28518333
66Lower limb muscle weakness (HP:0007340)2.27988113
67Metabolic alkalosis (HP:0200114)2.24236183
68Myelomeningocele (HP:0002475)2.23682094
69Morphological abnormality of the inner ear (HP:0011390)2.23569901
70Muscle fiber splitting (HP:0003555)2.22755730
71Split foot (HP:0001839)2.22243915
72Abnormality of the phalanges of the 2nd finger (HP:0009541)2.21185836
73Abnormality of the fetal cardiovascular system (HP:0010948)2.19365912
74Abnormal umbilical cord blood vessels (HP:0011403)2.19365912
75Single umbilical artery (HP:0001195)2.19365912
76Foot dorsiflexor weakness (HP:0009027)2.18712805
77Hypoplastic pelvis (HP:0008839)2.17659564
78Decreased motor nerve conduction velocity (HP:0003431)2.15852607
793-Methylglutaconic aciduria (HP:0003535)2.15225922
80Poor speech (HP:0002465)2.14207828
81Renal hypoplasia (HP:0000089)2.14116590
82Choreoathetosis (HP:0001266)2.13957054
83Agnosia (HP:0010524)2.08261579
84Delayed gross motor development (HP:0002194)2.06858669
85Abnormal lung lobation (HP:0002101)2.06334212
86Methylmalonic acidemia (HP:0002912)2.06170308
87Abnormality of the foot musculature (HP:0001436)2.05351714
88Shoulder girdle muscle weakness (HP:0003547)2.05314446
89Broad-based gait (HP:0002136)2.03887552
90Abnormality of the umbilical cord (HP:0010881)2.03761087
91Spastic tetraparesis (HP:0001285)2.02929780
92Medulloblastoma (HP:0002885)2.02758463
93Abnormality of the astrocytes (HP:0100707)2.02185431
94Astrocytoma (HP:0009592)2.02185431
95Abnormality of the musculature of the pelvis (HP:0001469)2.01656982
96Abnormality of the hip-girdle musculature (HP:0001445)2.01656982
97Bifid tongue (HP:0010297)2.00875725
98Axonal loss (HP:0003447)2.00729896
99Decreased testicular size (HP:0008734)1.99721149
100Partial agenesis of the corpus callosum (HP:0001338)1.99465540
101Aplasia/Hypoplasia of the tibia (HP:0005772)1.98300950
102Increased circulating renin level (HP:0000848)1.97022296
103Urinary urgency (HP:0000012)1.96905219
104Abnormality of the labia minora (HP:0012880)1.96876954
105Adrenal hypoplasia (HP:0000835)1.96385428
106Aplasia/hypoplasia of the humerus (HP:0006507)1.96034607
107Akinesia (HP:0002304)1.94868815
108Cutaneous finger syndactyly (HP:0010554)1.94788670
109Dental crowding (HP:0000678)1.94763179
110Hypokalemic alkalosis (HP:0001949)1.94241757
111Nonprogressive disorder (HP:0003680)1.93686989
112Secondary amenorrhea (HP:0000869)1.91831566
113Morphological abnormality of the pyramidal tract (HP:0002062)1.91708574
114Myotonia (HP:0002486)1.89283615
115Gonadal dysgenesis (HP:0000133)1.89263804
116Hammertoe (HP:0001765)1.88820549
117Exercise-induced muscle cramps (HP:0003710)1.88444847
118Hemiparesis (HP:0001269)1.88206916
119Abnormal gallbladder physiology (HP:0012438)1.88204013
120Cholecystitis (HP:0001082)1.88204013
121Acute necrotizing encephalopathy (HP:0006965)1.87030131
122Gowers sign (HP:0003391)1.86745946
123Abnormality of the septum pellucidum (HP:0007375)1.86721671
124Action tremor (HP:0002345)1.86699868
125Focal seizures (HP:0007359)1.85626308
126Short tibia (HP:0005736)1.85359874
127Papillary thyroid carcinoma (HP:0002895)1.85116808
128Cutaneous syndactyly (HP:0012725)1.84241522
129Facial cleft (HP:0002006)1.84191953
130Limb dystonia (HP:0002451)1.84016136
131Distal sensory impairment (HP:0002936)1.83623179
132Meckel diverticulum (HP:0002245)1.83386669
133Hypophosphatemic rickets (HP:0004912)1.83242204
134Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.83215784
135Abnormal hair whorl (HP:0010721)1.82714251
136Birth length less than 3rd percentile (HP:0003561)1.82144680
137Urinary incontinence (HP:0000020)1.81911892
138Paraparesis (HP:0002385)1.81610883
139Fibular aplasia (HP:0002990)1.81303710
140Type II lissencephaly (HP:0007260)1.81143267
141Esophageal atresia (HP:0002032)1.80731932
142Anophthalmia (HP:0000528)1.80728337
143Septo-optic dysplasia (HP:0100842)1.80480465
144Facial diplegia (HP:0001349)1.80444011
145Premature skin wrinkling (HP:0100678)1.80121676
146Type I transferrin isoform profile (HP:0003642)1.79533129
147Poor coordination (HP:0002370)1.78666987
148Absent radius (HP:0003974)1.78124195
149Acute encephalopathy (HP:0006846)1.76626342
150Abnormality of binocular vision (HP:0011514)1.76625046
151Diplopia (HP:0000651)1.76625046
152Postnatal microcephaly (HP:0005484)1.76391806
153Septate vagina (HP:0001153)1.75986537
154Oligodactyly (hands) (HP:0001180)1.75716406
155Anxiety (HP:0000739)1.75538760
156Abnormal mitochondria in muscle tissue (HP:0008316)1.75518134
157Vertebral clefting (HP:0008428)1.74852338
158Methylmalonic aciduria (HP:0012120)1.74379911
159Epileptic encephalopathy (HP:0200134)1.74048676
160Megalencephaly (HP:0001355)1.73694280
161Increased density of long bones (HP:0006392)1.72891785
162Hyporeflexia of lower limbs (HP:0002600)1.72855930
163Decreased lacrimation (HP:0000633)1.72697287
164Gaze-evoked nystagmus (HP:0000640)1.72487961
165Abnormality of the ileum (HP:0001549)1.71704700
166Aplasia/Hypoplasia of the lens (HP:0008063)1.71322908
167Ectopic anus (HP:0004397)1.70074306
168Muscle hypertrophy of the lower extremities (HP:0008968)1.69986525
169Steppage gait (HP:0003376)1.69475232
170Humeroradial synostosis (HP:0003041)1.69365276
171Synostosis involving the elbow (HP:0003938)1.69365276
172Glioma (HP:0009733)1.69101526
173Blue irides (HP:0000635)1.68896682
174Large for gestational age (HP:0001520)1.68833188
175Abnormality of chromosome stability (HP:0003220)1.67833699
176Tetraparesis (HP:0002273)1.66288531
177Renal salt wasting (HP:0000127)1.65088126
178Progressive macrocephaly (HP:0004481)1.64801019
179Aplasia involving forearm bones (HP:0009822)1.64689099
180Absent forearm bone (HP:0003953)1.64689099
181Relative macrocephaly (HP:0004482)1.63623894
182Abnormality of serine family amino acid metabolism (HP:0010894)1.63434419
183Abnormality of glycine metabolism (HP:0010895)1.63434419
184Premature rupture of membranes (HP:0001788)1.63307170
185Congenital malformation of the right heart (HP:0011723)1.62099970
186Double outlet right ventricle (HP:0001719)1.62099970
187Micropenis (HP:0000054)1.58645754
188Bile duct proliferation (HP:0001408)1.56708038
189Abnormal biliary tract physiology (HP:0012439)1.56708038
190Abnormality of serum amino acid levels (HP:0003112)1.55764248

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.87463515
2OXSR14.12868754
3ERBB44.02003495
4SRPK13.39641562
5MAPKAPK53.25022587
6EPHB12.80445033
7PKN12.75458681
8PDK22.75349080
9TIE12.70912089
10MKNK22.54301748
11CDK192.51655558
12WNK42.29708081
13BCR2.22800105
14PLK32.15044145
15TTK2.13946172
16EIF2AK12.13781853
17TRIM282.12172580
18CSNK1G32.05033969
19FGFR22.02005412
20CSNK1A1L1.99172332
21WNK11.97855223
22PBK1.96761948
23MET1.95410126
24UHMK11.92854625
25EIF2AK31.92832394
26WNK31.90304213
27TSSK61.87069823
28LIMK11.85335073
29VRK21.82048126
30BUB11.70053487
31CAMK2B1.68993682
32MUSK1.64364488
33PNCK1.61536867
34CSNK1G21.58276815
35CSNK1G11.57157679
36CDC71.53858981
37MARK11.53121212
38CASK1.51656143
39CLK11.51004165
40NEK61.48232505
41NEK11.47912061
42PLK41.46117570
43STK101.45660465
44STK161.41542374
45SGK2231.41321190
46SGK4941.41321190
47NTRK11.40454145
48TESK21.37769934
49ROCK21.37681508
50CAMK2D1.27846837
51NUAK11.11720175
52KDR1.08312220
53TAF11.08229082
54EPHA41.06319552
55PAK61.03640880
56CAMK2G1.01329371
57PRKD10.99870030
58MST40.97888955
59CCNB10.97236325
60DYRK20.96011216
61CAMK2A0.94407915
62VRK10.91964748
63PLK10.91860326
64FGR0.90781218
65PHKG20.88163932
66PHKG10.88163932
67CDK50.86426793
68FER0.84222803
69PRKCE0.83232175
70PIK3CA0.82495383
71STK38L0.82249390
72MARK20.81166002
73TNIK0.80088364
74ERBB30.79556098
75PRKCQ0.77707919
76CDK140.75292424
77ARAF0.74376138
78PLK20.73744004
79EPHB20.71871032
80PAK30.68607424
81NTRK20.68544007
82ICK0.67744875
83FRK0.67483398
84CDK80.65285989
85MAP3K120.65098602
86CDK150.64271520
87PRKCH0.64096893
88DMPK0.63935663
89PDPK10.63761159
90PRKD30.63516057
91BRSK10.63456672
92PTK2B0.63374490
93TYRO30.62995214
94PINK10.62962975
95BMPR1B0.62704207
96ROCK10.62100273
97CDK180.59712430
98RPS6KA50.59088487
99MKNK10.58919075
100PAK40.57944548
101CDK11A0.57651982
102MAPK130.57224802
103PRKG10.56066005
104FYN0.55472823
105NME10.55140678
106FGFR10.54117286
107GRK70.52267046
108MAPK120.52258112
109MAP3K60.50497866
110BRSK20.50285798
111KSR20.49822141
112PRKD20.49749013
113GSK3A0.49291294
114MAP2K70.49273278
115PRPF4B0.49259094
116ALK0.49184018
117MAP2K40.48990977
118ZAK0.48839244
119PRKCG0.48726449
120ERBB20.48323683
121EIF2AK20.48188269
122ATM0.47544336
123MAPK150.47439557
124PRKG20.47079661
125PRKACB0.46716424
126PTK20.45235751
127IRAK20.45074383
128BCKDK0.44515977
129CSNK1A10.44261436
130DAPK10.43412904
131CAMK1G0.42537898
132FES0.42098354
133GRK10.41755373
134PDK10.41689752
135FLT30.41245236
136ADRBK20.41194859
137ADRBK10.40104525
138LMTK20.39355502
139LATS20.38555638
140EGFR0.37233313
141MINK10.36333460
142NTRK30.36136416
143MAP2K60.35780335
144CSNK1D0.33795172
145MAPK100.33790427
146OBSCN0.33549431
147MAP3K90.32990833
148DAPK30.32779168
149KSR10.32552527
150PRKDC0.32410019
151MAP3K40.32342472
152STK110.32338693
153MAP2K20.32161972
154ACVR1B0.31177576
155RET0.31106069
156TRPM70.31102208
157MAP3K80.30707975

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.37892551
2Fatty acid elongation_Homo sapiens_hsa000624.60111542
3Proteasome_Homo sapiens_hsa030504.07878108
4Steroid biosynthesis_Homo sapiens_hsa001003.96867319
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.64479095
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.75880458
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.68280282
8Ether lipid metabolism_Homo sapiens_hsa005652.65608186
9Mismatch repair_Homo sapiens_hsa034302.29906220
10Non-homologous end-joining_Homo sapiens_hsa034502.01715563
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.95865228
12Pyruvate metabolism_Homo sapiens_hsa006201.95700315
13Nitrogen metabolism_Homo sapiens_hsa009101.89754577
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.82757789
15Oxidative phosphorylation_Homo sapiens_hsa001901.81701939
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.80895208
17DNA replication_Homo sapiens_hsa030301.71427806
18RNA polymerase_Homo sapiens_hsa030201.68855878
19Axon guidance_Homo sapiens_hsa043601.63809509
20Sulfur metabolism_Homo sapiens_hsa009201.62897274
21Vitamin B6 metabolism_Homo sapiens_hsa007501.60764674
22GABAergic synapse_Homo sapiens_hsa047271.58958299
23Histidine metabolism_Homo sapiens_hsa003401.55611514
24Homologous recombination_Homo sapiens_hsa034401.55082590
25Parkinsons disease_Homo sapiens_hsa050121.51259692
26Glutamatergic synapse_Homo sapiens_hsa047241.50901081
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.49906259
28Protein export_Homo sapiens_hsa030601.46657494
29Serotonergic synapse_Homo sapiens_hsa047261.42650366
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.42130770
31Butanoate metabolism_Homo sapiens_hsa006501.41533949
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.41134458
33Sphingolipid metabolism_Homo sapiens_hsa006001.39964146
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.39439029
35Fatty acid biosynthesis_Homo sapiens_hsa000611.38419359
36Morphine addiction_Homo sapiens_hsa050321.38409954
37Alzheimers disease_Homo sapiens_hsa050101.34734297
38SNARE interactions in vesicular transport_Homo sapiens_hsa041301.33268850
39Long-term depression_Homo sapiens_hsa047301.32946549
40Linoleic acid metabolism_Homo sapiens_hsa005911.31326082
41Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.28222310
42Basal transcription factors_Homo sapiens_hsa030221.21453947
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.20291083
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.19108589
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15074635
46Circadian entrainment_Homo sapiens_hsa047131.13421265
47Fanconi anemia pathway_Homo sapiens_hsa034601.12392559
48Nucleotide excision repair_Homo sapiens_hsa034201.11776703
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.09217508
50Cocaine addiction_Homo sapiens_hsa050301.09131202
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.09044949
52Base excision repair_Homo sapiens_hsa034101.04933291
53Renal cell carcinoma_Homo sapiens_hsa052111.03823896
54Biosynthesis of amino acids_Homo sapiens_hsa012301.03407717
55Carbon metabolism_Homo sapiens_hsa012001.02508292
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.02321844
57Fatty acid degradation_Homo sapiens_hsa000711.02173120
58Oocyte meiosis_Homo sapiens_hsa041141.01457269
59RNA transport_Homo sapiens_hsa030131.01395070
60Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.01306250
61Sphingolipid signaling pathway_Homo sapiens_hsa040710.98359618
62One carbon pool by folate_Homo sapiens_hsa006700.97607693
63RNA degradation_Homo sapiens_hsa030180.95197925
64Vibrio cholerae infection_Homo sapiens_hsa051100.95018279
65Adherens junction_Homo sapiens_hsa045200.93484000
66Hippo signaling pathway_Homo sapiens_hsa043900.93161142
67Spliceosome_Homo sapiens_hsa030400.92048197
68Dopaminergic synapse_Homo sapiens_hsa047280.91243213
69Nicotine addiction_Homo sapiens_hsa050330.90729599
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90703061
71Salivary secretion_Homo sapiens_hsa049700.89213603
72Collecting duct acid secretion_Homo sapiens_hsa049660.88859334
73TGF-beta signaling pathway_Homo sapiens_hsa043500.86939534
74Gastric acid secretion_Homo sapiens_hsa049710.85970416
75Glutathione metabolism_Homo sapiens_hsa004800.85634156
76Cell cycle_Homo sapiens_hsa041100.85619312
77Tight junction_Homo sapiens_hsa045300.83807060
78Renin secretion_Homo sapiens_hsa049240.83273953
79Arginine and proline metabolism_Homo sapiens_hsa003300.82026218
80Cardiac muscle contraction_Homo sapiens_hsa042600.81323548
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.81166300
82Propanoate metabolism_Homo sapiens_hsa006400.80635676
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77650920
84Synaptic vesicle cycle_Homo sapiens_hsa047210.77501548
85Phototransduction_Homo sapiens_hsa047440.75834791
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75291526
87Ovarian steroidogenesis_Homo sapiens_hsa049130.74830075
88Ras signaling pathway_Homo sapiens_hsa040140.74200501
89beta-Alanine metabolism_Homo sapiens_hsa004100.73136458
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.72377728
91Lysine degradation_Homo sapiens_hsa003100.71656125
92Cholinergic synapse_Homo sapiens_hsa047250.71413220
93Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70060815
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68688784
95Wnt signaling pathway_Homo sapiens_hsa043100.67362920
96Gap junction_Homo sapiens_hsa045400.66904847
97Basal cell carcinoma_Homo sapiens_hsa052170.66265461
98Amphetamine addiction_Homo sapiens_hsa050310.64839100
99Endocytosis_Homo sapiens_hsa041440.64431343
100N-Glycan biosynthesis_Homo sapiens_hsa005100.64328312
101Huntingtons disease_Homo sapiens_hsa050160.62699608
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62584147
103Autoimmune thyroid disease_Homo sapiens_hsa053200.61554470
104Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61191716
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61100218
106Vitamin digestion and absorption_Homo sapiens_hsa049770.58692477
107Fatty acid metabolism_Homo sapiens_hsa012120.58515831
108Dorso-ventral axis formation_Homo sapiens_hsa043200.57017640
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.56766145
110Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56497675
111Pancreatic secretion_Homo sapiens_hsa049720.55671120
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55586954
113mRNA surveillance pathway_Homo sapiens_hsa030150.55272047
114Taste transduction_Homo sapiens_hsa047420.54682086
115Olfactory transduction_Homo sapiens_hsa047400.54138423
116Rheumatoid arthritis_Homo sapiens_hsa053230.53318738
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52567125
118Pyrimidine metabolism_Homo sapiens_hsa002400.52117733
119Long-term potentiation_Homo sapiens_hsa047200.52094603
120ErbB signaling pathway_Homo sapiens_hsa040120.52023539
121Mineral absorption_Homo sapiens_hsa049780.51585123
122Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50432511
123Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48191920
124cAMP signaling pathway_Homo sapiens_hsa040240.47934939
125Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47857922
126Arachidonic acid metabolism_Homo sapiens_hsa005900.47453081
127Selenocompound metabolism_Homo sapiens_hsa004500.46172252
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.42859401
129Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42806210
130Purine metabolism_Homo sapiens_hsa002300.41572647
131Folate biosynthesis_Homo sapiens_hsa007900.41381944
132African trypanosomiasis_Homo sapiens_hsa051430.39962176
133Rap1 signaling pathway_Homo sapiens_hsa040150.39710505
134Central carbon metabolism in cancer_Homo sapiens_hsa052300.38885992
135Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38699316
136Hedgehog signaling pathway_Homo sapiens_hsa043400.38575842
137Calcium signaling pathway_Homo sapiens_hsa040200.37399641
138Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37333546
139Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.37287028
140Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36747996
141Dilated cardiomyopathy_Homo sapiens_hsa054140.36687736
142ECM-receptor interaction_Homo sapiens_hsa045120.36508633
143Galactose metabolism_Homo sapiens_hsa000520.36340553
144Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34082693
145Phagosome_Homo sapiens_hsa041450.33618818
146Oxytocin signaling pathway_Homo sapiens_hsa049210.32849167
147Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32697725
148Lysosome_Homo sapiens_hsa041420.32435617
149Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32003611
150Peroxisome_Homo sapiens_hsa041460.31425036
151Melanogenesis_Homo sapiens_hsa049160.30649542
152Steroid hormone biosynthesis_Homo sapiens_hsa001400.29902070
153Insulin secretion_Homo sapiens_hsa049110.29807881
154Metabolic pathways_Homo sapiens_hsa011000.29071508

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