KLHL33

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1muscle filament sliding (GO:0030049)8.47195310
2actin-myosin filament sliding (GO:0033275)8.47195310
3regulation of skeletal muscle contraction (GO:0014819)8.41512207
4sarcoplasmic reticulum calcium ion transport (GO:0070296)8.05467759
5skeletal muscle contraction (GO:0003009)7.24583875
6positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.97525497
7actin-mediated cell contraction (GO:0070252)6.90615559
8skeletal muscle adaptation (GO:0043501)6.77064034
9plasma membrane repair (GO:0001778)6.31395920
10sarcomere organization (GO:0045214)6.00449952
11behavioral response to nicotine (GO:0035095)5.87768804
12regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.81908271
13regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.56979990
14regulation of cell communication by electrical coupling (GO:0010649)5.54230797
15carnitine shuttle (GO:0006853)5.48315215
16striated muscle contraction (GO:0006941)5.47678959
17myofibril assembly (GO:0030239)5.30626983
18actin filament-based movement (GO:0030048)5.21859238
19neuronal action potential propagation (GO:0019227)5.16850743
20glycogen catabolic process (GO:0005980)5.05413148
21skeletal muscle fiber development (GO:0048741)5.01613710
22response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.97294481
23creatine metabolic process (GO:0006600)4.93960197
24glucan catabolic process (GO:0009251)4.72852684
25regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.66179797
26fatty acid transmembrane transport (GO:1902001)4.62212267
27negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.50033350
28myotube cell development (GO:0014904)4.49265001
29tricarboxylic acid cycle (GO:0006099)4.47169890
30regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.43279207
31cardiac muscle contraction (GO:0060048)4.42805197
32cellular polysaccharide catabolic process (GO:0044247)4.39079269
33regulation of acyl-CoA biosynthetic process (GO:0050812)4.32398287
34muscle contraction (GO:0006936)4.28988617
35striated muscle atrophy (GO:0014891)4.22123800
36response to inactivity (GO:0014854)4.21752895
37carnitine transmembrane transport (GO:1902603)4.16185017
38regulation of relaxation of muscle (GO:1901077)4.15896502
39polysaccharide catabolic process (GO:0000272)4.15801521
40actomyosin structure organization (GO:0031032)4.13786208
41striated muscle adaptation (GO:0014888)4.11803857
42response to muscle activity (GO:0014850)4.03339094
43positive regulation of calcium ion transmembrane transporter activity (GO:1901021)4.01068232
44membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.01018152
45cardiac myofibril assembly (GO:0055003)4.00600201
46regulation of calcium ion transmembrane transport (GO:1903169)3.99424165
47regulation of calcium ion transmembrane transporter activity (GO:1901019)3.99424165
48regulation of coenzyme metabolic process (GO:0051196)3.93220347
49regulation of cofactor metabolic process (GO:0051193)3.93220347
50negative regulation of potassium ion transmembrane transport (GO:1901380)3.90253954
51muscle system process (GO:0003012)3.87689510
52pyrimidine ribonucleoside catabolic process (GO:0046133)3.87560451
53regulation of actin filament-based movement (GO:1903115)3.83087031
54purine nucleotide salvage (GO:0032261)3.81538587
55NADH metabolic process (GO:0006734)3.80281369
56amino-acid betaine transport (GO:0015838)3.79342048
57carnitine transport (GO:0015879)3.79342048
58kynurenine metabolic process (GO:0070189)3.76551976
59muscle fiber development (GO:0048747)3.73893788
60neuromuscular synaptic transmission (GO:0007274)3.73121397
61regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.70614957
62muscle atrophy (GO:0014889)3.69808551
63glycogen biosynthetic process (GO:0005978)3.69449264
64glucan biosynthetic process (GO:0009250)3.69449264
65succinate metabolic process (GO:0006105)3.63616050
66detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.60910232
67regulation of membrane repolarization (GO:0060306)3.55901344
68ubiquinone biosynthetic process (GO:0006744)3.54207995
69regulation of striated muscle contraction (GO:0006942)3.53230333
70glycogen metabolic process (GO:0005977)3.47770578
71regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.44847859
72regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.44189699
73membrane depolarization during action potential (GO:0086010)3.43317661
74glucan metabolic process (GO:0044042)3.40701197
75cellular glucan metabolic process (GO:0006073)3.40701197
76positive regulation of cation channel activity (GO:2001259)3.37769513
77skeletal muscle tissue regeneration (GO:0043403)3.37246615
78muscle adaptation (GO:0043500)3.32489525
79tryptophan catabolic process (GO:0006569)3.29544009
80indole-containing compound catabolic process (GO:0042436)3.29544009
81indolalkylamine catabolic process (GO:0046218)3.29544009
82potassium ion import (GO:0010107)3.27948557
83ubiquinone metabolic process (GO:0006743)3.27296748
84indolalkylamine metabolic process (GO:0006586)3.25630625
85cellular ketone body metabolic process (GO:0046950)3.24614089
86L-fucose catabolic process (GO:0042355)3.22289022
87fucose catabolic process (GO:0019317)3.22289022
88L-fucose metabolic process (GO:0042354)3.22289022
89cytidine metabolic process (GO:0046087)3.21088835
90cytidine catabolic process (GO:0006216)3.21088835
91cytidine deamination (GO:0009972)3.21088835
92regulation of skeletal muscle cell differentiation (GO:2001014)3.19745126
93DNA deamination (GO:0045006)3.18427889
94sulfation (GO:0051923)3.18240041
95synaptic transmission, cholinergic (GO:0007271)3.17366462
96regulation of sulfur metabolic process (GO:0042762)3.14725414
972-oxoglutarate metabolic process (GO:0006103)3.12657728
98positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.11695321
99neuromuscular junction development (GO:0007528)3.11489642
100neuronal action potential (GO:0019228)3.11351370
101regulation of cation channel activity (GO:2001257)3.09010114
102striated muscle cell development (GO:0055002)3.08854620
103oxaloacetate metabolic process (GO:0006107)3.05202790
104reflex (GO:0060004)3.04406190
105detection of light stimulus involved in sensory perception (GO:0050962)3.03825520
106detection of light stimulus involved in visual perception (GO:0050908)3.03825520
107muscle cell cellular homeostasis (GO:0046716)3.03168980
108cardiac muscle cell development (GO:0055013)3.03141013
109regulation of sequestering of triglyceride (GO:0010889)3.02998404
110regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.97472997
111mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.96646921
112mitochondrial respiratory chain complex I assembly (GO:0032981)2.96646921
113NADH dehydrogenase complex assembly (GO:0010257)2.96646921
114gamma-aminobutyric acid transport (GO:0015812)2.96525867
115regulation of glucokinase activity (GO:0033131)2.96325220
116regulation of hexokinase activity (GO:1903299)2.96325220
117regulation of action potential (GO:0098900)2.96197852
118striated muscle hypertrophy (GO:0014897)2.95396757
119positive regulation of sodium ion transmembrane transport (GO:1902307)2.94587884
120auditory receptor cell stereocilium organization (GO:0060088)2.92287208
121cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.91363246
122positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.90458486
123regulation of sarcomere organization (GO:0060297)2.89325583
124ketone body metabolic process (GO:1902224)2.88238496
125primary amino compound metabolic process (GO:1901160)2.87680999
126cardiac muscle hypertrophy (GO:0003300)2.85810436
127mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.83500636
128protein complex biogenesis (GO:0070271)2.82576413
129quinone biosynthetic process (GO:1901663)2.81346313
130muscle organ development (GO:0007517)2.81077100
131response to activity (GO:0014823)2.80342224
132tryptophan metabolic process (GO:0006568)2.79809478
133positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.79563081
134cardiac cell development (GO:0055006)2.78613193
135cornea development in camera-type eye (GO:0061303)2.77889701
136cellular carbohydrate catabolic process (GO:0044275)2.77095937
137response to pheromone (GO:0019236)2.76302656
138muscle structure development (GO:0061061)2.76257764
139negative regulation of cytosolic calcium ion concentration (GO:0051481)2.75912587
140negative regulation of cAMP-mediated signaling (GO:0043951)2.75732121
141indole-containing compound metabolic process (GO:0042430)2.74972554
142serotonin metabolic process (GO:0042428)2.70773645
143otic vesicle formation (GO:0030916)2.68530435
144positive regulation of fatty acid oxidation (GO:0046321)2.66256781
145G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.63290035
146rhodopsin mediated signaling pathway (GO:0016056)2.60141763
147mitochondrial respiratory chain complex assembly (GO:0033108)2.59378096
148regulation of rhodopsin mediated signaling pathway (GO:0022400)2.59082234
149somite development (GO:0061053)2.58094135
150action potential (GO:0001508)2.57807888
151amine catabolic process (GO:0009310)2.54570129
152cellular biogenic amine catabolic process (GO:0042402)2.54570129
153negative regulation of reactive oxygen species metabolic process (GO:2000378)2.53018322
154regulation of neurotransmitter uptake (GO:0051580)2.51849752
155water-soluble vitamin biosynthetic process (GO:0042364)2.51837205
156positive regulation of meiosis (GO:0045836)2.49408332
157dopamine transport (GO:0015872)2.49079219
158negative regulation of mast cell activation (GO:0033004)2.48020002
159postsynaptic membrane organization (GO:0001941)2.47315544
160neural tube formation (GO:0001841)2.46843410
161negative regulation of transcription regulatory region DNA binding (GO:2000678)2.46136108
162cellular response to ATP (GO:0071318)2.44031390
163cAMP catabolic process (GO:0006198)2.43345765
164electron transport chain (GO:0022900)2.42929365
165alanine transport (GO:0032328)2.42493639
166inner ear receptor stereocilium organization (GO:0060122)2.42397013
167calcium ion import (GO:0070509)2.42328109

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.76168979
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.48037208
3VDR_22108803_ChIP-Seq_LS180_Human3.32419780
4ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.04532689
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.01526215
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.96432513
7IGF1R_20145208_ChIP-Seq_DFB_Human2.68437591
8DROSHA_22980978_ChIP-Seq_HELA_Human2.51065124
9ESR1_20079471_ChIP-ChIP_T-47D_Human2.48449386
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.44727794
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.24093513
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.16645188
13PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.15164571
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.13830345
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12581875
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.08590917
17CDX2_19796622_ChIP-Seq_MESCs_Mouse2.02632418
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.01306673
19TAF15_26573619_Chip-Seq_HEK293_Human1.98889810
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.96779828
21EP300_21415370_ChIP-Seq_HL-1_Mouse1.95024893
22TBX20_22328084_ChIP-Seq_HEART_Mouse1.94985845
23TBX20_22080862_ChIP-Seq_HEART_Mouse1.94985845
24EZH2_18974828_ChIP-Seq_MESCs_Mouse1.92938331
25RNF2_18974828_ChIP-Seq_MESCs_Mouse1.92938331
26MTF2_20144788_ChIP-Seq_MESCs_Mouse1.92319108
27ER_23166858_ChIP-Seq_MCF-7_Human1.90212603
28FUS_26573619_Chip-Seq_HEK293_Human1.89137321
29ZNF263_19887448_ChIP-Seq_K562_Human1.87807089
30P300_19829295_ChIP-Seq_ESCs_Human1.84102477
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.83171911
32RARB_27405468_Chip-Seq_BRAIN_Mouse1.82159601
33SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.76344060
34* EZH2_27294783_Chip-Seq_ESCs_Mouse1.75628937
35ZNF274_21170338_ChIP-Seq_K562_Hela1.75193164
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.74925799
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.72689804
38EWS_26573619_Chip-Seq_HEK293_Human1.71807747
39AR_21572438_ChIP-Seq_LNCaP_Human1.71166332
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68656567
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.66454318
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.64384372
43JARID2_20075857_ChIP-Seq_MESCs_Mouse1.62351471
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.61367567
45JARID2_20064375_ChIP-Seq_MESCs_Mouse1.61016133
46BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.56528175
47MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.53751211
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53693915
49DNAJC2_21179169_ChIP-ChIP_NT2_Human1.52682182
50NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.51011379
51EZH2_27304074_Chip-Seq_ESCs_Mouse1.50635254
52UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50604516
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.49222826
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.48262457
55REST_18959480_ChIP-ChIP_MESCs_Mouse1.46673991
56* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.46315063
57SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45346740
58STAT3_23295773_ChIP-Seq_U87_Human1.44878151
59EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.44805675
60CTCF_27219007_Chip-Seq_Bcells_Human1.42387562
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41915399
62SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.40368811
63SOX2_19829295_ChIP-Seq_ESCs_Human1.39992159
64NANOG_19829295_ChIP-Seq_ESCs_Human1.39992159
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.39406334
66TCF4_23295773_ChIP-Seq_U87_Human1.37484637
67EZH2_27294783_Chip-Seq_NPCs_Mouse1.36341711
68NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35917689
69TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35539604
70TP53_22573176_ChIP-Seq_HFKS_Human1.35494249
71* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34359904
72* CBP_20019798_ChIP-Seq_JUKART_Human1.34359904
73POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33039111
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33039111
75ESR2_21235772_ChIP-Seq_MCF-7_Human1.32276761
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31458851
77RARG_19884340_ChIP-ChIP_MEFs_Mouse1.30756903
78HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.30597708
79EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30423158
80MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30111288
81ERG_21242973_ChIP-ChIP_JURKAT_Human1.29649070
82SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29375805
83REST_21632747_ChIP-Seq_MESCs_Mouse1.29323532
84NFE2_27457419_Chip-Seq_LIVER_Mouse1.28911542
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26837397
86ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.24613788
87SOX2_21211035_ChIP-Seq_LN229_Gbm1.23565749
88KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23483398
89SMAD3_21741376_ChIP-Seq_EPCs_Human1.23326507
90SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.21971675
91RNF2_27304074_Chip-Seq_ESCs_Mouse1.21754410
92ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.20120986
93MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19813109
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19312898
95CRX_20693478_ChIP-Seq_RETINA_Mouse1.18884319
96FLI1_21867929_ChIP-Seq_TH2_Mouse1.18295029
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16902680
98EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.15722048
99KDM2B_26808549_Chip-Seq_K562_Human1.15166493
100CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14556845
101RNF2_27304074_Chip-Seq_NSC_Mouse1.14027010
102GATA3_21878914_ChIP-Seq_MCF-7_Human1.13569417
103FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13478624
104FOXA1_25329375_ChIP-Seq_VCAP_Human1.13478624
105TCF4_22108803_ChIP-Seq_LS180_Human1.13267071
106GBX2_23144817_ChIP-Seq_PC3_Human1.13031583
107PRDM14_20953172_ChIP-Seq_ESCs_Human1.12292260
108PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.12054900
109NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10816456
110SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10182786
111RUNX2_22187159_ChIP-Seq_PCA_Human1.09903571
112MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.09132621
113NCOR_22424771_ChIP-Seq_293T_Human1.08097188
114ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07896580
115EED_16625203_ChIP-ChIP_MESCs_Mouse1.06203954
116P53_22387025_ChIP-Seq_ESCs_Mouse1.06105478
117FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05359562
118SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.04622690
119OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04154656
120HOXB7_26014856_ChIP-Seq_BT474_Human1.03899261
121AR_19668381_ChIP-Seq_PC3_Human1.03446352
122AR_20517297_ChIP-Seq_VCAP_Human1.03215433
123TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02983666
124EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02305810
125GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.01404051
126NANOG_18555785_Chip-Seq_ESCs_Mouse1.00508856
127WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00183078
128CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99682244
129OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99282182
130TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99252837
131CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98858463
132STAT3_18555785_Chip-Seq_ESCs_Mouse0.97214684
133CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.97191750
134CTCF_21964334_ChIP-Seq_BJAB-B_Human0.96008381
135SMAD4_21799915_ChIP-Seq_A2780_Human0.95786143
136ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.95449362
137NOTCH1_21737748_ChIP-Seq_TLL_Human0.94797099
138P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94677132
139* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94644478
140KDM2B_26808549_Chip-Seq_DND41_Human0.93898825
141* ETV2_25802403_ChIP-Seq_MESCs_Mouse0.93814257
142TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.93268977
143KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92591586
144BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92090854
145KLF4_19829295_ChIP-Seq_ESCs_Human0.91720556
146ESR1_21235772_ChIP-Seq_MCF-7_Human0.90862925
147CREB1_26743006_Chip-Seq_LNCaP_Human0.89887339
148TDRD3_21172665_ChIP-Seq_MCF-7_Human0.89827490
149FOXH1_21741376_ChIP-Seq_ESCs_Human0.89708152
150LXR_22292898_ChIP-Seq_THP-1_Human0.88309783
151SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.88066940
152OCT4_20526341_ChIP-Seq_ESCs_Human0.87805150
153WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87580483
154SMAD4_21741376_ChIP-Seq_EPCs_Human0.87375708
155MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.87282649
156SA1_27219007_Chip-Seq_Bcells_Human0.85012906
157NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84653116
158NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84653116
159EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.84631332
160LXR_22158963_ChIP-Seq_LIVER_Mouse0.84574055
161SMAD4_21741376_ChIP-Seq_HESCs_Human0.84546398
162* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84541783
163GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83303681
164BCAT_22108803_ChIP-Seq_LS180_Human0.83105865
165TP53_20018659_ChIP-ChIP_R1E_Mouse0.82852824
166FOXA2_19822575_ChIP-Seq_HepG2_Human0.80655633
167* AR_25329375_ChIP-Seq_VCAP_Human0.79971937
168SMC4_20622854_ChIP-Seq_HELA_Human0.79728320
169CTNNB1_20460455_ChIP-Seq_HCT116_Human0.78708240
170RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78528116
171TP63_22573176_ChIP-Seq_HFKS_Human0.78084500
172FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.77799079
173* PPARA_22158963_ChIP-Seq_LIVER_Mouse0.77448188
174SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.77059357
175P68_20966046_ChIP-Seq_HELA_Human0.76777821

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio6.51636941
2MP0003646_muscle_fatigue6.45034683
3MP0000751_myopathy5.41340543
4MP0000749_muscle_degeneration5.18984934
5MP0002837_dystrophic_cardiac_calcinosis4.78077785
6MP0004036_abnormal_muscle_relaxation3.98132270
7MP0000747_muscle_weakness3.58529520
8MP0002106_abnormal_muscle_physiology3.42817371
9MP0002269_muscular_atrophy3.10283286
10MP0000759_abnormal_skeletal_muscle3.06458078
11MP0004130_abnormal_muscle_cell3.04836882
12MP0004087_abnormal_muscle_fiber2.98766384
13MP0005369_muscle_phenotype2.88301673
14MP0005620_abnormal_muscle_contractility2.81195304
15MP0000750_abnormal_muscle_regeneration2.61685465
16MP0004084_abnormal_cardiac_muscle2.55119143
17MP0004233_abnormal_muscle_weight2.51655523
18MP0004215_abnormal_myocardial_fiber2.35818875
19MP0005330_cardiomyopathy2.08507602
20MP0002332_abnormal_exercise_endurance2.00914478
21MP0002638_abnormal_pupillary_reflex1.88634115
22MP0004859_abnormal_synaptic_plasticity1.86624890
23MP0005551_abnormal_eye_electrophysiolog1.84209268
24MP0004270_analgesia1.81531307
25MP0008877_abnormal_DNA_methylation1.80428932
26MP0008872_abnormal_physiological_respon1.76981376
27MP0003136_yellow_coat_color1.76425414
28MP0006036_abnormal_mitochondrial_physio1.75834832
29MP0000569_abnormal_digit_pigmentation1.65775593
30MP0002972_abnormal_cardiac_muscle1.65494484
31MP0002102_abnormal_ear_morphology1.64739005
32MP0002108_abnormal_muscle_morphology1.62693018
33MP0000372_irregular_coat_pigmentation1.60557193
34MP0005645_abnormal_hypothalamus_physiol1.59873283
35MP0001485_abnormal_pinna_reflex1.59166147
36MP0004484_altered_response_of1.58832165
37MP0002876_abnormal_thyroid_physiology1.56136677
38MP0006276_abnormal_autonomic_nervous1.54385073
39MP0003137_abnormal_impulse_conducting1.47957561
40MP0002653_abnormal_ependyma_morphology1.43539450
41MP0009046_muscle_twitch1.43263079
42MP0008569_lethality_at_weaning1.35996945
43MP0000733_abnormal_muscle_development1.35973686
44MP0004185_abnormal_adipocyte_glucose1.32882927
45MP0000013_abnormal_adipose_tissue1.28966991
46MP0005253_abnormal_eye_physiology1.26410091
47MP0005666_abnormal_adipose_tissue1.25870817
48MP0010630_abnormal_cardiac_muscle1.25462347
49MP0002822_catalepsy1.24928277
50MP0006292_abnormal_olfactory_placode1.23319794
51MP0001986_abnormal_taste_sensitivity1.23035324
52MP0006072_abnormal_retinal_apoptosis1.22782991
53MP0001544_abnormal_cardiovascular_syste1.18650413
54MP0005385_cardiovascular_system_phenoty1.18650413
55MP0008775_abnormal_heart_ventricle1.18507237
56MP0003635_abnormal_synaptic_transmissio1.17961800
57MP0001529_abnormal_vocalization1.17318200
58MP0000631_abnormal_neuroendocrine_gland1.14396643
59MP0003221_abnormal_cardiomyocyte_apopto1.14381373
60MP0004885_abnormal_endolymph1.12339216
61MP0002733_abnormal_thermal_nociception1.10600799
62MP0002971_abnormal_brown_adipose1.10554143
63MP0006035_abnormal_mitochondrial_morpho1.09792082
64MP0003787_abnormal_imprinting1.09391760
65MP0004133_heterotaxia1.07869108
66MP0004147_increased_porphyrin_level1.06978314
67MP0002736_abnormal_nociception_after1.06095641
68MP0005167_abnormal_blood-brain_barrier1.05979166
69MP0001970_abnormal_pain_threshold1.05316379
70MP0004043_abnormal_pH_regulation1.04952011
71MP0000427_abnormal_hair_cycle1.04813830
72MP0002234_abnormal_pharynx_morphology1.04354712
73MP0002938_white_spotting1.03893619
74MP0005646_abnormal_pituitary_gland1.02717528
75MP0005266_abnormal_metabolism0.99441582
76MP0005375_adipose_tissue_phenotype0.98840431
77MP0004085_abnormal_heartbeat0.98618190
78MP0003011_delayed_dark_adaptation0.98416979
79MP0008875_abnormal_xenobiotic_pharmacok0.93981560
80MP0006138_congestive_heart_failure0.93582814
81MP0009745_abnormal_behavioral_response0.93081915
82MP0002272_abnormal_nervous_system0.91885455
83MP0002909_abnormal_adrenal_gland0.90592160
84MP0002064_seizures0.90558299
85MP0001984_abnormal_olfaction0.85380784
86MP0008961_abnormal_basal_metabolism0.82653351
87MP0004142_abnormal_muscle_tone0.82123144
88MP0002160_abnormal_reproductive_system0.81469399
89MP0004742_abnormal_vestibular_system0.81395914
90MP0003806_abnormal_nucleotide_metabolis0.81342558
91MP0002557_abnormal_social/conspecific_i0.81244096
92MP0002067_abnormal_sensory_capabilities0.80415321
93MP0001440_abnormal_grooming_behavior0.79423579
94MP0001299_abnormal_eye_distance/0.78654175
95MP0002734_abnormal_mechanical_nocicepti0.78588519
96MP0005083_abnormal_biliary_tract0.78352980
97MP0004510_myositis0.76905379
98MP0000026_abnormal_inner_ear0.76309464
99MP0002277_abnormal_respiratory_mucosa0.74978037
100MP0003656_abnormal_erythrocyte_physiolo0.73717968
101MP0005670_abnormal_white_adipose0.72938547
102MP0002078_abnormal_glucose_homeostasis0.72504054
103MP0003705_abnormal_hypodermis_morpholog0.71291587
104MP0005174_abnormal_tail_pigmentation0.71015910
105MP0002752_abnormal_somatic_nervous0.70819772
106MP0005195_abnormal_posterior_eye0.70620749
107MP0002063_abnormal_learning/memory/cond0.70299059
108MP0000003_abnormal_adipose_tissue0.70090422
109MP0001963_abnormal_hearing_physiology0.69598464
110MP0002127_abnormal_cardiovascular_syste0.69534586
111MP0005084_abnormal_gallbladder_morpholo0.69288161
112MP0003890_abnormal_embryonic-extraembry0.69283890
113MP0009780_abnormal_chondrocyte_physiolo0.67777846
114MP0005423_abnormal_somatic_nervous0.66814022
115MP0003045_fibrosis0.66749327
116MP0002066_abnormal_motor_capabilities/c0.63720517
117MP0003880_abnormal_central_pattern0.63307942
118MP0004924_abnormal_behavior0.62766837
119MP0005386_behavior/neurological_phenoty0.62766837
120MP0005535_abnormal_body_temperature0.62264547
121MP0003329_amyloid_beta_deposits0.57947290
122MP0005334_abnormal_fat_pad0.56532367
123MP0001501_abnormal_sleep_pattern0.56297089
124MP0005584_abnormal_enzyme/coenzyme_acti0.53210481
125MP0002139_abnormal_hepatobiliary_system0.52829235
126MP0003633_abnormal_nervous_system0.52239091
127MP0003950_abnormal_plasma_membrane0.51646482
128MP0002572_abnormal_emotion/affect_behav0.51385274
129MP0004858_abnormal_nervous_system0.50793222
130MP0000266_abnormal_heart_morphology0.50126764
131MP0000230_abnormal_systemic_arterial0.50077110
132MP0003195_calcinosis0.49576796
133MP0002184_abnormal_innervation0.47792687
134MP0000955_abnormal_spinal_cord0.44707054
135MP0001486_abnormal_startle_reflex0.43964089
136MP0005452_abnormal_adipose_tissue0.42080138
137MP0008874_decreased_physiological_sensi0.41190206
138MP0003828_pulmonary_edema0.39647176
139MP0002089_abnormal_postnatal_growth/wei0.39599274
140MP0000343_altered_response_to0.39381349
141MP0001968_abnormal_touch/_nociception0.38956255
142MP0004811_abnormal_neuron_physiology0.38330837
143MP0004134_abnormal_chest_morphology0.36924583
144MP0002735_abnormal_chemical_nociception0.36686578

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)8.60746536
2Exercise-induced muscle cramps (HP:0003710)7.82790036
3Muscle fiber inclusion bodies (HP:0100299)7.67018692
4Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.33008298
5Muscle hypertrophy of the lower extremities (HP:0008968)7.11328197
6Nemaline bodies (HP:0003798)6.65762296
7Calf muscle hypertrophy (HP:0008981)6.45257531
8Type 1 muscle fiber predominance (HP:0003803)5.75378131
9Difficulty running (HP:0009046)5.39857310
10Myoglobinuria (HP:0002913)5.36369597
11Distal arthrogryposis (HP:0005684)5.34941441
12Myopathic facies (HP:0002058)5.28832425
13Muscle fiber splitting (HP:0003555)5.10790891
14Myotonia (HP:0002486)4.78970068
15Hyporeflexia of lower limbs (HP:0002600)4.75837800
16Muscle stiffness (HP:0003552)4.75777853
17Round ear (HP:0100830)4.71363823
18EMG: myopathic abnormalities (HP:0003458)4.42263171
19Abnormality of the calf musculature (HP:0001430)4.41247631
20Ulnar deviation of the wrist (HP:0003049)4.36735770
21Increased connective tissue (HP:0009025)4.22439221
22Rhabdomyolysis (HP:0003201)4.17208660
23Sudden death (HP:0001699)3.87578716
24Abnormality of the left ventricular outflow tract (HP:0011103)3.73668790
25Subaortic stenosis (HP:0001682)3.73668790
26Absent phalangeal crease (HP:0006109)3.64520818
27Calcaneovalgus deformity (HP:0001848)3.62752220
28Abnormality of skeletal muscle fiber size (HP:0012084)3.55055452
29Pancreatic cysts (HP:0001737)3.54812124
30Increased variability in muscle fiber diameter (HP:0003557)3.47518147
31Asymmetric septal hypertrophy (HP:0001670)3.38077284
32Difficulty climbing stairs (HP:0003551)3.35953761
33Abnormality of midbrain morphology (HP:0002418)3.27731233
34Molar tooth sign on MRI (HP:0002419)3.27731233
35Pancreatic fibrosis (HP:0100732)3.25326074
36Congenital stationary night blindness (HP:0007642)3.23084550
37Deformed tarsal bones (HP:0008119)3.22060297
38True hermaphroditism (HP:0010459)3.21020927
39Rimmed vacuoles (HP:0003805)3.10113929
40Abnormal finger flexion creases (HP:0006143)3.04018420
41Neck muscle weakness (HP:0000467)3.01405411
42Areflexia of lower limbs (HP:0002522)2.97485003
43Nephronophthisis (HP:0000090)2.92190789
44Shoulder girdle muscle weakness (HP:0003547)2.87719432
45Abnormality of alanine metabolism (HP:0010916)2.85485582
46Hyperalaninemia (HP:0003348)2.85485582
47Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.85485582
48Malignant hyperthermia (HP:0002047)2.82845034
49Large for gestational age (HP:0001520)2.80641039
50Pelvic girdle muscle weakness (HP:0003749)2.79497784
51Hyperkalemia (HP:0002153)2.77611992
52Abnormality of the hip-girdle musculature (HP:0001445)2.77365466
53Abnormality of the musculature of the pelvis (HP:0001469)2.77365466
54Bundle branch block (HP:0011710)2.71743595
55Ventricular tachycardia (HP:0004756)2.70250368
56Frequent falls (HP:0002359)2.66671838
57Hyperventilation (HP:0002883)2.59628294
58Genetic anticipation (HP:0003743)2.56704323
59Type II lissencephaly (HP:0007260)2.54347015
60Abnormality of the renal cortex (HP:0011035)2.54157542
61Congenital, generalized hypertrichosis (HP:0004540)2.46032554
62Inability to walk (HP:0002540)2.43900505
63Attenuation of retinal blood vessels (HP:0007843)2.43409992
64EMG: neuropathic changes (HP:0003445)2.42319885
65Abnormality of the renal medulla (HP:0100957)2.40835852
66Muscular dystrophy (HP:0003560)2.34752547
67Pendular nystagmus (HP:0012043)2.32423932
68Distal lower limb muscle weakness (HP:0009053)2.29961894
69Proximal amyotrophy (HP:0007126)2.28513181
70Focal motor seizures (HP:0011153)2.28446581
71Acute necrotizing encephalopathy (HP:0006965)2.27585460
72Fatigable weakness (HP:0003473)2.26717499
73Abnormality of the neuromuscular junction (HP:0003398)2.26717499
74Medial flaring of the eyebrow (HP:0010747)2.26323207
75Broad-based gait (HP:0002136)2.23263700
76Limb-girdle muscle weakness (HP:0003325)2.20714482
77Abolished electroretinogram (ERG) (HP:0000550)2.19786087
78Hypoplastic ischia (HP:0003175)2.16814663
79Lipoatrophy (HP:0100578)2.16106965
80Progressive cerebellar ataxia (HP:0002073)2.14185376
81Cystic liver disease (HP:0006706)2.13331469
82Cholelithiasis (HP:0001081)2.12882225
83Mitochondrial inheritance (HP:0001427)2.12784438
84Paralysis (HP:0003470)2.09054206
85Furrowed tongue (HP:0000221)2.07686389
86Abnormal drinking behavior (HP:0030082)2.07034845
87Polydipsia (HP:0001959)2.07034845
88Limb-girdle muscle atrophy (HP:0003797)2.06976792
89Decreased circulating renin level (HP:0003351)2.06786768
90Heart block (HP:0012722)2.06174286
91Facial diplegia (HP:0001349)2.04360146
92Distal lower limb amyotrophy (HP:0008944)2.04269832
93Palpitations (HP:0001962)2.03833725
94Atrial fibrillation (HP:0005110)2.02478514
95Mildly elevated creatine phosphokinase (HP:0008180)2.02147177
96Sclerocornea (HP:0000647)2.00356163
97Abnormality of the calcaneus (HP:0008364)2.00272809
98Progressive inability to walk (HP:0002505)2.00007939
99Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.97785481
100Progressive macrocephaly (HP:0004481)1.97417238
101Increased CSF lactate (HP:0002490)1.97391919
102Decreased central vision (HP:0007663)1.97103949
103Tubular atrophy (HP:0000092)1.95431449
104Increased corneal curvature (HP:0100692)1.94990244
105Keratoconus (HP:0000563)1.94990244
106Abnormality of the ischium (HP:0003174)1.93966155
107Chronic hepatic failure (HP:0100626)1.93453399
108Dilated cardiomyopathy (HP:0001644)1.93246786
109Acute encephalopathy (HP:0006846)1.93212334
110Abnormal atrioventricular conduction (HP:0005150)1.92872607
111Febrile seizures (HP:0002373)1.92777777
112Gowers sign (HP:0003391)1.92625367
113Ventricular arrhythmia (HP:0004308)1.92572129
114Concave nail (HP:0001598)1.92076872
115Gaze-evoked nystagmus (HP:0000640)1.91874564
116Achilles tendon contracture (HP:0001771)1.90809049
117Primary atrial arrhythmia (HP:0001692)1.90793672
118Congenital hepatic fibrosis (HP:0002612)1.90319729
119Visual hallucinations (HP:0002367)1.89004746
120Abnormal gallbladder morphology (HP:0012437)1.88969837
121Prolonged QT interval (HP:0001657)1.88528819
122Generalized muscle weakness (HP:0003324)1.87845364
123Dysmetric saccades (HP:0000641)1.87263079
124Hyperglycinuria (HP:0003108)1.86912974
125Nonprogressive disorder (HP:0003680)1.86868744
126Renal cortical cysts (HP:0000803)1.86801170
127Slender build (HP:0001533)1.84428052
128Left ventricular hypertrophy (HP:0001712)1.83480764
129Absent rod-and cone-mediated responses on ERG (HP:0007688)1.82948888
130Abnormal rod and cone electroretinograms (HP:0008323)1.82924056
131Clumsiness (HP:0002312)1.82178304
132Scapular winging (HP:0003691)1.81759327
133Supraventricular tachycardia (HP:0004755)1.81307369
134Gout (HP:0001997)1.81306059
135Severe muscular hypotonia (HP:0006829)1.80848633
136Cerebellar dysplasia (HP:0007033)1.80829257
137Ventricular fibrillation (HP:0001663)1.80795406
138Bulbar palsy (HP:0001283)1.79602346
139Abnormality of the shoulder girdle musculature (HP:0001435)1.79039706
140Lower limb amyotrophy (HP:0007210)1.78134622
141Aplasia/Hypoplasia of the tongue (HP:0010295)1.78013770
142Optic disc pallor (HP:0000543)1.77953902
1433-Methylglutaconic aciduria (HP:0003535)1.76475425
144Ketoacidosis (HP:0001993)1.76308599
145Supraventricular arrhythmia (HP:0005115)1.76165960
146Abnormality of the Achilles tendon (HP:0005109)1.75527763
147Centrally nucleated skeletal muscle fibers (HP:0003687)1.75284354
148Hepatic necrosis (HP:0002605)1.74735537
149Protruding tongue (HP:0010808)1.73936573
150Hemiparesis (HP:0001269)1.73646032
151Chorioretinal atrophy (HP:0000533)1.72837408
152Fair hair (HP:0002286)1.72320921
153Hepatocellular necrosis (HP:0001404)1.71783191
154Oligomenorrhea (HP:0000876)1.71259301
155Anencephaly (HP:0002323)1.70683619
156Gait imbalance (HP:0002141)1.70553107
157Lissencephaly (HP:0001339)1.70520286
158Pheochromocytoma (HP:0002666)1.68565206
159Atrioventricular block (HP:0001678)1.68334961
160Atonic seizures (HP:0010819)1.67721662
161Progressive muscle weakness (HP:0003323)1.66682015
162Abnormal mitochondria in muscle tissue (HP:0008316)1.65354612
163Spinal rigidity (HP:0003306)1.64038797
164Right ventricular cardiomyopathy (HP:0011663)1.64011130
165Increased purine levels (HP:0004368)1.63974033

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN6.41564162
2TTN6.16001997
3PHKG15.47389907
4PHKG25.47389907
5FRK4.89680145
6NME13.22946426
7ADRBK23.13236259
8BMPR1B2.69679927
9PINK12.58270402
10NEK12.41459211
11GRK12.39931770
12ACVR1B2.34364939
13PIK3CG2.34104518
14MAP2K42.30034673
15PDK32.28543672
16PDK42.28543672
17MAP2K32.26164899
18WNK32.17590399
19ZAK2.03771199
20TRIB31.88295112
21MAPK131.86144236
22MAP3K71.82840304
23DMPK1.82375721
24PIK3CA1.77134797
25BCKDK1.69815037
26WNK41.60297090
27TLK11.58366215
28MAP4K21.55086885
29RIPK11.48422549
30NUAK11.47595195
31MAPK121.46557199
32MUSK1.42887826
33TAOK31.42348009
34PDK21.40656541
35MAP3K41.34806887
36OXSR11.33472524
37TNIK1.23485134
38TXK1.18752019
39CASK1.17430696
40LMTK21.08593939
41MAP2K61.07088744
42ADRBK11.06797278
43NTRK31.03160142
44PRKAA10.91790034
45STK390.91742582
46MKNK20.91473276
47CAMKK20.89110470
48PKN20.87525698
49PRKAA20.83790157
50PAK60.83263220
51WNK10.81433054
52TGFBR10.80840827
53STK38L0.78290034
54CAMK2G0.78209078
55MAP2K70.68984990
56DYRK20.68737387
57SIK10.66434344
58MAP3K90.65821027
59MAP2K10.65095466
60STK380.64547009
61KSR20.62622392
62TAOK20.61050057
63PRKCE0.60417650
64INSRR0.57924735
65CAMK2D0.57686711
66STK240.56019414
67MINK10.55801586
68TAOK10.54859344
69TEC0.54043587
70DAPK20.53755927
71LIMK10.53711311
72SGK30.53626220
73VRK10.53495471
74CAMKK10.53132224
75NEK90.52898568
76SGK10.51611980
77CAMK1G0.51566892
78MYLK0.51163986
79MAPKAPK30.49004326
80MAPK150.48131470
81MAP3K120.47721080
82PRKD10.47633096
83PRKCH0.47541417
84PRKACB0.46360212
85PRKCQ0.46107052
86PTK60.46060903
87RPS6KA30.43907325
88EPHB10.43390730
89CAMK2A0.43231871
90PKN10.42485592
91CSNK1G20.42266729
92PDPK10.41750315
93PAK30.41424774
94PRKCG0.41190330
95MAP3K10.40813988
96MAP3K50.40594400
97PDK10.39713191
98RET0.39257753
99MARK10.39195657
100SGK20.38954484
101MAPKAPK50.38811739
102PNCK0.38785139
103TRPM70.38584848
104PRKACA0.37425972
105ROCK10.36939701
106MAP3K110.36707267
107STK110.36135311
108CAMK10.36118860
109AKT20.35944386
110CAMK40.35807911
111MAPK110.35785291
112PRKG10.35718284
113RPS6KA50.35699419
114MAP3K30.34632419
115ERBB30.33965925
116CSNK1G10.33351696
117CSNK1D0.33210830
118MAP3K60.32915293
119TNK20.32820429
120NTRK20.32043497
121BRSK20.31890722
122IKBKB0.30713863
123TIE10.30423236
124ITK0.30310533
125CSNK1A10.30308500
126TRIM280.30160977
127SGK4940.29692602
128SGK2230.29692602
129SYK0.29571385
130CAMK2B0.29476371
131RPS6KA60.29225635
132PRKCA0.29221694
133MKNK10.28678486
134PRKACG0.28203332
135ILK0.27420672
136NTRK10.27247002
137CDK50.26612642
138ROCK20.26073724
139TAF10.25313612
140LATS20.25092603
141CCNB10.24828435
142GRK70.24534110
143PRKD30.23695162
144DYRK1A0.23328660
145LATS10.23048501
146CSNK1G30.22730590
147PDGFRA0.22683813
148STK30.22089533
149PTK2B0.21316662
150ICK0.20501496
151CDC42BPA0.20445338
152CDK190.19222791

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.19341951
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.17050486
3Cardiac muscle contraction_Homo sapiens_hsa042603.13850096
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.01029914
5Phototransduction_Homo sapiens_hsa047442.87381557
6Dilated cardiomyopathy_Homo sapiens_hsa054142.76900705
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.73764333
8Linoleic acid metabolism_Homo sapiens_hsa005912.45245411
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.35241639
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.31967615
11Propanoate metabolism_Homo sapiens_hsa006402.13835132
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.97646296
13Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.93016450
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.89951864
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.84460068
16Oxytocin signaling pathway_Homo sapiens_hsa049211.84149058
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.82649969
18Carbon metabolism_Homo sapiens_hsa012001.79921919
19Glucagon signaling pathway_Homo sapiens_hsa049221.78863851
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.75173326
21Selenocompound metabolism_Homo sapiens_hsa004501.75010652
22Calcium signaling pathway_Homo sapiens_hsa040201.67983959
23Parkinsons disease_Homo sapiens_hsa050121.66723394
24Starch and sucrose metabolism_Homo sapiens_hsa005001.61776092
25Circadian rhythm_Homo sapiens_hsa047101.60130609
26Alzheimers disease_Homo sapiens_hsa050101.58669090
27Oxidative phosphorylation_Homo sapiens_hsa001901.58215184
28Insulin signaling pathway_Homo sapiens_hsa049101.55331229
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.52025489
30Pyruvate metabolism_Homo sapiens_hsa006201.46534360
31Ether lipid metabolism_Homo sapiens_hsa005651.45740446
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.42523668
33Gastric acid secretion_Homo sapiens_hsa049711.41311396
34Fatty acid degradation_Homo sapiens_hsa000711.40701922
35Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.40290903
36Insulin resistance_Homo sapiens_hsa049311.39087351
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35962833
38Circadian entrainment_Homo sapiens_hsa047131.32080670
39ABC transporters_Homo sapiens_hsa020101.31180528
40Adipocytokine signaling pathway_Homo sapiens_hsa049201.29873657
41Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.27349899
42Insulin secretion_Homo sapiens_hsa049111.26496852
43Long-term potentiation_Homo sapiens_hsa047201.23613122
44Nicotine addiction_Homo sapiens_hsa050331.23505989
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.21808814
46GABAergic synapse_Homo sapiens_hsa047271.21133086
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.21040451
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.20558009
49Arginine biosynthesis_Homo sapiens_hsa002201.19279031
50cGMP-PKG signaling pathway_Homo sapiens_hsa040221.19113861
51Type II diabetes mellitus_Homo sapiens_hsa049301.16008932
52Homologous recombination_Homo sapiens_hsa034401.15629782
53Fatty acid metabolism_Homo sapiens_hsa012121.12822846
54Peroxisome_Homo sapiens_hsa041461.12475341
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.11063540
56AMPK signaling pathway_Homo sapiens_hsa041521.10936873
57Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.10176451
58Synaptic vesicle cycle_Homo sapiens_hsa047211.10168087
59RNA polymerase_Homo sapiens_hsa030201.08755003
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08745124
61Aldosterone synthesis and secretion_Homo sapiens_hsa049251.08713838
62Caffeine metabolism_Homo sapiens_hsa002321.07803994
63Butanoate metabolism_Homo sapiens_hsa006501.07556159
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.07101835
65Biosynthesis of amino acids_Homo sapiens_hsa012301.06326049
66GnRH signaling pathway_Homo sapiens_hsa049121.05455248
67Salivary secretion_Homo sapiens_hsa049701.04149679
68Renin secretion_Homo sapiens_hsa049241.02476700
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.99646675
70Long-term depression_Homo sapiens_hsa047300.99293459
71Fructose and mannose metabolism_Homo sapiens_hsa000510.97686891
72Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96800153
73Olfactory transduction_Homo sapiens_hsa047400.94876296
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94492388
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.94484270
76Cholinergic synapse_Homo sapiens_hsa047250.92764652
77Ovarian steroidogenesis_Homo sapiens_hsa049130.92512567
78RNA degradation_Homo sapiens_hsa030180.92413533
79Glutamatergic synapse_Homo sapiens_hsa047240.90875928
80Basal transcription factors_Homo sapiens_hsa030220.90832400
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.90417162
82Chemical carcinogenesis_Homo sapiens_hsa052040.88642288
83Histidine metabolism_Homo sapiens_hsa003400.88243978
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83642979
85Galactose metabolism_Homo sapiens_hsa000520.82808576
86Amphetamine addiction_Homo sapiens_hsa050310.82502794
87Dopaminergic synapse_Homo sapiens_hsa047280.81239569
88Morphine addiction_Homo sapiens_hsa050320.80435643
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.78633420
90Nitrogen metabolism_Homo sapiens_hsa009100.78292186
91Fanconi anemia pathway_Homo sapiens_hsa034600.78175591
92Huntingtons disease_Homo sapiens_hsa050160.76354424
93Protein export_Homo sapiens_hsa030600.74909375
94Intestinal immune network for IgA production_Homo sapiens_hsa046720.74481587
95Arginine and proline metabolism_Homo sapiens_hsa003300.73263266
96Regulation of autophagy_Homo sapiens_hsa041400.72577523
97Arachidonic acid metabolism_Homo sapiens_hsa005900.72433355
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69550789
99Glycerolipid metabolism_Homo sapiens_hsa005610.68809881
100Viral myocarditis_Homo sapiens_hsa054160.68687267
101cAMP signaling pathway_Homo sapiens_hsa040240.62347888
102mTOR signaling pathway_Homo sapiens_hsa041500.62340710
103Fat digestion and absorption_Homo sapiens_hsa049750.62032192
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.60201585
105Purine metabolism_Homo sapiens_hsa002300.59935704
106Retinol metabolism_Homo sapiens_hsa008300.59837616
107Tight junction_Homo sapiens_hsa045300.58819759
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58751974
109PPAR signaling pathway_Homo sapiens_hsa033200.58027218
110Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57375003
111Pancreatic secretion_Homo sapiens_hsa049720.57050977
112Taste transduction_Homo sapiens_hsa047420.56832728
113Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56143188
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56007132
115Primary immunodeficiency_Homo sapiens_hsa053400.55827373
116beta-Alanine metabolism_Homo sapiens_hsa004100.54750011
117Bile secretion_Homo sapiens_hsa049760.54173832
118Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53001266
119Gap junction_Homo sapiens_hsa045400.52901093
120Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52820181
121Fatty acid biosynthesis_Homo sapiens_hsa000610.52008867
122Phenylalanine metabolism_Homo sapiens_hsa003600.51976752
123One carbon pool by folate_Homo sapiens_hsa006700.49765458
124Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49731319
125Metabolic pathways_Homo sapiens_hsa011000.49658951
126Dorso-ventral axis formation_Homo sapiens_hsa043200.48824911
127Focal adhesion_Homo sapiens_hsa045100.48641336
128FoxO signaling pathway_Homo sapiens_hsa040680.48420570
129MAPK signaling pathway_Homo sapiens_hsa040100.47394372
130Serotonergic synapse_Homo sapiens_hsa047260.46139795
131Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43589603
132HIF-1 signaling pathway_Homo sapiens_hsa040660.39567886
133Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36821233
134Tryptophan metabolism_Homo sapiens_hsa003800.36737970
135Estrogen signaling pathway_Homo sapiens_hsa049150.36611626
136Fatty acid elongation_Homo sapiens_hsa000620.36092594
137VEGF signaling pathway_Homo sapiens_hsa043700.35890815
138Platelet activation_Homo sapiens_hsa046110.30979008
139Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30554198
140Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30188956
141Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29909422
142Asthma_Homo sapiens_hsa053100.29902556
143Pentose phosphate pathway_Homo sapiens_hsa000300.29583994
144Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.27562308
145Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27192285
146Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.27142101
147Cocaine addiction_Homo sapiens_hsa050300.26499018

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