KLHL31

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.58654316
2muscle filament sliding (GO:0030049)6.43680980
3actin-myosin filament sliding (GO:0033275)6.43680980
4regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)6.09106335
5negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.07729793
6creatine metabolic process (GO:0006600)5.51161788
7negative regulation of potassium ion transmembrane transport (GO:1901380)5.50572433
8actin-mediated cell contraction (GO:0070252)5.35296776
9NADH metabolic process (GO:0006734)5.29849647
10regulation of relaxation of muscle (GO:1901077)5.28682062
11muscle contraction (GO:0006936)5.17739182
12regulation of the force of heart contraction (GO:0002026)4.90916376
13regulation of skeletal muscle contraction (GO:0014819)4.82170756
14response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.73911618
15muscle system process (GO:0003012)4.73622664
16heart contraction (GO:0060047)4.65539077
17heart process (GO:0003015)4.65539077
18striated muscle adaptation (GO:0014888)4.51150238
19carnitine shuttle (GO:0006853)4.48250839
20myofibril assembly (GO:0030239)4.47270310
21respiratory chain complex IV assembly (GO:0008535)4.43214285
22mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.42747586
23cardiac muscle hypertrophy in response to stress (GO:0014898)4.40969804
24muscle hypertrophy in response to stress (GO:0003299)4.40969804
25cardiac muscle adaptation (GO:0014887)4.40969804
26facial nerve structural organization (GO:0021612)4.37947580
27regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.32271844
28ribosomal small subunit assembly (GO:0000028)4.29237299
29sarcomere organization (GO:0045214)4.26387365
30muscle fiber development (GO:0048747)4.23137984
31skeletal muscle fiber development (GO:0048741)4.22997550
32positive regulation of calcium ion transmembrane transporter activity (GO:1901021)4.21347438
33regulation of calcineurin-NFAT signaling cascade (GO:0070884)4.19887297
34cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.19387993
35ventricular cardiac muscle cell action potential (GO:0086005)4.14964226
36tricarboxylic acid cycle (GO:0006099)4.11102706
37cardiac myofibril assembly (GO:0055003)4.10817579
38myotube cell development (GO:0014904)4.08698556
39muscle cell cellular homeostasis (GO:0046716)4.01074798
40relaxation of cardiac muscle (GO:0055119)3.99883422
41respiratory electron transport chain (GO:0022904)3.97778851
42regulation of calcium ion transmembrane transport (GO:1903169)3.97102082
43regulation of calcium ion transmembrane transporter activity (GO:1901019)3.97102082
44mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.95350325
45lymphoid progenitor cell differentiation (GO:0002320)3.94525141
46regulation of membrane repolarization (GO:0060306)3.93742894
47fatty acid transmembrane transport (GO:1902001)3.92775612
48regulation of cardiac muscle cell contraction (GO:0086004)3.92648383
49skeletal muscle contraction (GO:0003009)3.91901746
50electron transport chain (GO:0022900)3.91277006
51glycogen catabolic process (GO:0005980)3.89470100
52striated muscle cell development (GO:0055002)3.89288465
53regulation of actin filament-based movement (GO:1903115)3.88986155
54plasma membrane repair (GO:0001778)3.88513125
55skeletal muscle tissue development (GO:0007519)3.88018637
56response to caffeine (GO:0031000)3.87597852
57energy coupled proton transport, down electrochemical gradient (GO:0015985)3.86662454
58ATP synthesis coupled proton transport (GO:0015986)3.86662454
59negative regulation of calcium ion transmembrane transport (GO:1903170)3.85697718
60negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.85697718
61ubiquinone biosynthetic process (GO:0006744)3.84557640
62quinone biosynthetic process (GO:1901663)3.84557640
63membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.82845125
64DNA deamination (GO:0045006)3.82745781
65cytochrome complex assembly (GO:0017004)3.80406173
66negative regulation of myotube differentiation (GO:0010832)3.76336584
67response to inactivity (GO:0014854)3.75943337
68cell communication involved in cardiac conduction (GO:0086065)3.74701202
69glycogen biosynthetic process (GO:0005978)3.71817493
70glucan biosynthetic process (GO:0009250)3.71817493
71sarcoplasmic reticulum calcium ion transport (GO:0070296)3.69923390
72regulation of ATPase activity (GO:0043462)3.68886143
73regulation of ATP catabolic process (GO:1903289)3.68886143
74striated muscle contraction (GO:0006941)3.66309263
75relaxation of muscle (GO:0090075)3.65455687
76viral transcription (GO:0019083)3.65147402
77glucan catabolic process (GO:0009251)3.64216503
78muscle adaptation (GO:0043500)3.64013875
79regulation of sequestering of triglyceride (GO:0010889)3.62909029
80cardiac muscle contraction (GO:0060048)3.61102321
81regulation of heart rate (GO:0002027)3.60147659
82ribosomal small subunit biogenesis (GO:0042274)3.57847482
832-oxoglutarate metabolic process (GO:0006103)3.55658113
84regulation of muscle system process (GO:0090257)3.55436504
85oxidative phosphorylation (GO:0006119)3.54545806
86regulation of cell communication by electrical coupling (GO:0010649)3.53886293
87regulation of muscle contraction (GO:0006937)3.53080912
88regulation of cardiac muscle contraction (GO:0055117)3.52927070
89regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.52608755
90mitochondrial respiratory chain complex I assembly (GO:0032981)3.51873900
91NADH dehydrogenase complex assembly (GO:0010257)3.51873900
92mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.51873900
93response to epinephrine (GO:0071871)3.48562314
94actin filament-based movement (GO:0030048)3.44936959
95cell communication by electrical coupling (GO:0010644)3.44613893
96protein complex biogenesis (GO:0070271)3.44320612
97cardiac muscle cell action potential (GO:0086001)3.44097275
98translational termination (GO:0006415)3.43507120
99striated muscle atrophy (GO:0014891)3.42043290
100proteasome assembly (GO:0043248)3.41645915
101cardiac muscle tissue morphogenesis (GO:0055008)3.41072123
102carnitine transmembrane transport (GO:1902603)3.41027877
103cellular polysaccharide catabolic process (GO:0044247)3.39989647
104platelet dense granule organization (GO:0060155)3.37892309
105ubiquinone metabolic process (GO:0006743)3.34945190
106mesonephros development (GO:0001823)3.33993741
107muscle structure development (GO:0061061)3.32907844
108muscle cell development (GO:0055001)3.32531799
109muscle organ development (GO:0007517)3.32390795
110mannosylation (GO:0097502)3.31824729
111polyketide metabolic process (GO:0030638)3.31035377
112doxorubicin metabolic process (GO:0044598)3.31035377
113daunorubicin metabolic process (GO:0044597)3.31035377
114positive regulation of cation channel activity (GO:2001259)3.30980734
115aerobic respiration (GO:0009060)3.30591577
116cellular response to epinephrine stimulus (GO:0071872)3.29582930
117cranial nerve structural organization (GO:0021604)3.24082230
118cardiac muscle cell development (GO:0055013)3.23776929
119regulation of striated muscle contraction (GO:0006942)3.21080623
120GPI anchor biosynthetic process (GO:0006506)3.19431191
121SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.17073891
122muscle tissue morphogenesis (GO:0060415)3.13137825
123cotranslational protein targeting to membrane (GO:0006613)3.12052682
124protein targeting to ER (GO:0045047)3.08708383
125short-term memory (GO:0007614)3.08200657
126regulation of sarcomere organization (GO:0060297)3.07538007
127mitochondrial respiratory chain complex assembly (GO:0033108)3.06646203
128cardiac cell development (GO:0055006)3.04314272
129cranial nerve morphogenesis (GO:0021602)3.03913028
130regulation of pigment cell differentiation (GO:0050932)2.99173883
131establishment of protein localization to endoplasmic reticulum (GO:0072599)2.97392008
132cardiac muscle hypertrophy (GO:0003300)2.97345051
133protein localization to endoplasmic reticulum (GO:0070972)2.94021597
134positive regulation of cellular amine metabolic process (GO:0033240)2.89676196
135negative regulation of protein localization to cell surface (GO:2000009)2.88979831
136striated muscle hypertrophy (GO:0014897)2.87282322
137pattern specification involved in kidney development (GO:0061004)2.86975876
138postsynaptic membrane organization (GO:0001941)2.84280751
139translational elongation (GO:0006414)2.79435023
140positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.78221064
141thyroid gland development (GO:0030878)2.77234835
142negative regulation of metanephros development (GO:0072217)2.76360188
143ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.76172759
144adult heart development (GO:0007512)2.75481258
145negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.70003920
146regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.67473370
147response to muscle activity (GO:0014850)2.66225105
148actomyosin structure organization (GO:0031032)2.65966395
149regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.65028497
150response to interferon-beta (GO:0035456)2.61706188
151maturation of SSU-rRNA (GO:0030490)2.61246163
152muscle hypertrophy (GO:0014896)2.59806426
153negative regulation of transcription by competitive promoter binding (GO:0010944)2.59520569
154skeletal muscle adaptation (GO:0043501)2.58474034
155cytidine deamination (GO:0009972)2.58415027
156cytidine metabolic process (GO:0046087)2.58415027
157cytidine catabolic process (GO:0006216)2.58415027
158GPI anchor metabolic process (GO:0006505)2.58359743
159C-terminal protein lipidation (GO:0006501)2.57644585
160negative regulation of T-helper cell differentiation (GO:0045623)2.56944811
161negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.56944811
162GTP biosynthetic process (GO:0006183)2.56914046
163regulation of mitochondrial translation (GO:0070129)2.55272413

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.62567543
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.40452477
3EZH2_22144423_ChIP-Seq_EOC_Human5.12390887
4TBX20_22080862_ChIP-Seq_HEART_Mouse3.32418680
5TBX20_22328084_ChIP-Seq_HEART_Mouse3.32418680
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.23851800
7CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.12240077
8LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.88218905
9ESR1_20079471_ChIP-ChIP_T-47D_Human2.67818273
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.66233739
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.65630880
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.41100660
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.38674770
14ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.38406813
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.36918639
16SCL_19346495_ChIP-Seq_HPC-7_Human2.22519052
17SRF_21415370_ChIP-Seq_HL-1_Mouse2.19688634
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.17532227
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.15593032
20NOTCH1_21737748_ChIP-Seq_TLL_Human2.13811979
21PCGF2_27294783_Chip-Seq_ESCs_Mouse2.13596882
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.10346528
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.06644141
24RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.06470410
25GATA4_21415370_ChIP-Seq_HL-1_Mouse2.05084786
26GABP_17652178_ChIP-ChIP_JURKAT_Human2.00184377
27VDR_22108803_ChIP-Seq_LS180_Human1.95276271
28GATA1_22025678_ChIP-Seq_K562_Human1.94959421
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.90829038
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87447807
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.82341523
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.81979155
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71964951
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.71246085
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.68963624
36NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.66945767
37IGF1R_20145208_ChIP-Seq_DFB_Human1.62224352
38IRF8_22096565_ChIP-ChIP_GC-B_Human1.59736310
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.58981583
40LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.55994204
41ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.54913627
42CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.53593235
43EST1_17652178_ChIP-ChIP_JURKAT_Human1.53450635
44FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.53063415
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.52520952
46NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.51342721
47E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.51311118
48GBX2_23144817_ChIP-Seq_PC3_Human1.50711006
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.47547615
50EZH2_27304074_Chip-Seq_ESCs_Mouse1.43495309
51ERG_20887958_ChIP-Seq_HPC-7_Mouse1.42003978
52EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.41519086
53BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.40608250
54* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.39568584
55ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.39403440
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39045423
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.38997052
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.37855356
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.35474158
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35031713
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33829851
62TAF15_26573619_Chip-Seq_HEK293_Human1.32776451
63IRF1_19129219_ChIP-ChIP_H3396_Human1.30291070
64CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.30290371
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28065868
66EP300_21415370_ChIP-Seq_HL-1_Mouse1.27684391
67TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25898503
68ETS1_20019798_ChIP-Seq_JURKAT_Human1.25242956
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24988555
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23176776
71MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.22214057
72RARG_19884340_ChIP-ChIP_MEFs_Mouse1.21387238
73RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20052540
74EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18876099
75NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.17959267
76NRF2_20460467_ChIP-Seq_MEFs_Mouse1.17959267
77SMAD4_21799915_ChIP-Seq_A2780_Human1.17471720
78NFIB_24661679_ChIP-Seq_LUNG_Mouse1.17430114
79FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17338107
80IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.16916563
81RUNX1_27457419_Chip-Seq_LIVER_Mouse1.12958033
82GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.12904081
83TRIM28_21343339_ChIP-Seq_HEK293_Human1.12377466
84* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11434198
85EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.11061353
86NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10872976
87STAT3_18555785_Chip-Seq_ESCs_Mouse1.10708674
88P53_22387025_ChIP-Seq_ESCs_Mouse1.09269413
89MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.08383584
90ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08163007
91VDR_23849224_ChIP-Seq_CD4+_Human1.07984129
92IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06947010
93EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06911371
94SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06693255
95SOX2_21211035_ChIP-Seq_LN229_Gbm1.06121183
96LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05887987
97MYC_18555785_ChIP-Seq_MESCs_Mouse1.05733322
98CRX_20693478_ChIP-Seq_RETINA_Mouse1.05674645
99MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.04360821
100TAL1_26923725_Chip-Seq_HPCs_Mouse1.02889827
101YY1_21170310_ChIP-Seq_MESCs_Mouse1.02656074
102ESR2_21235772_ChIP-Seq_MCF-7_Human1.02459117
103SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.02286704
104GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02240812
105MYC_18358816_ChIP-ChIP_MESCs_Mouse1.01414896
106EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01027126
107BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99623887
108ELK1_19687146_ChIP-ChIP_HELA_Human0.98773450
109NMYC_18555785_Chip-Seq_ESCs_Mouse0.98396593
110NANOG_20526341_ChIP-Seq_ESCs_Human0.98271040
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97863273
112OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97645670
113SMAD3_21741376_ChIP-Seq_HESCs_Human0.96694296
114ISL1_27105846_Chip-Seq_CPCs_Mouse0.96247335
115STAT1_20625510_ChIP-Seq_HELA_Human0.95760205
116PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.95309803
117CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95172218
118LXR_22158963_ChIP-Seq_LIVER_Mouse0.95166120
119NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95165701
120ZNF274_21170338_ChIP-Seq_K562_Hela0.94517719
121MYC_18940864_ChIP-ChIP_HL60_Human0.94283933
122SPI1_23547873_ChIP-Seq_NB4_Human0.94096321
123CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94033470
124ZNF263_19887448_ChIP-Seq_K562_Human0.93374061
125FUS_26573619_Chip-Seq_HEK293_Human0.93259596
126OCT4_18555785_Chip-Seq_ESCs_Mouse0.93067023
127SMAD_19615063_ChIP-ChIP_OVARY_Human0.93010329
128TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92868676
129ZFX_18555785_Chip-Seq_ESCs_Mouse0.92295720
130E2F1_18555785_Chip-Seq_ESCs_Mouse0.92287837
131SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92081063
132SOX2_18555785_Chip-Seq_ESCs_Mouse0.92043776
133SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.91902285
134WT1_19549856_ChIP-ChIP_CCG9911_Human0.91523610
135FOXP3_21729870_ChIP-Seq_TREG_Human0.91216541
136P300_18555785_Chip-Seq_ESCs_Mouse0.90990078
137THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.90112601
138PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.89464430
139EED_16625203_ChIP-ChIP_MESCs_Mouse0.89156079
140MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.89147493
141FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.88708699
142PIAS1_25552417_ChIP-Seq_VCAP_Human0.88449757
143THAP11_20581084_ChIP-Seq_MESCs_Mouse0.88436942
144HTT_18923047_ChIP-ChIP_STHdh_Human0.88139313
145ER_23166858_ChIP-Seq_MCF-7_Human0.87527103
146CJUN_26792858_Chip-Seq_BT549_Human0.87280129
147STAT1_17558387_ChIP-Seq_HELA_Human0.87105816
148MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86815762
149RNF2_27304074_Chip-Seq_NSC_Mouse0.86254794
150GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.85840433
151CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.85315705
152SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.84863470
153RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.84764363
154AR_21572438_ChIP-Seq_LNCaP_Human0.84552464
155CLOCK_20551151_ChIP-Seq_293T_Human0.84468411
156STAT4_19710469_ChIP-ChIP_TH1__Mouse0.84188876
157* TCF4_23295773_ChIP-Seq_U87_Human0.84162083
158JARID2_20075857_ChIP-Seq_MESCs_Mouse0.84141521
159TP63_19390658_ChIP-ChIP_HaCaT_Human0.83589109
160STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.83314733
161TBL1_22424771_ChIP-Seq_293T_Human0.81852500
162* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.81593611
163TOP2B_26459242_ChIP-Seq_MCF-7_Human0.81110653
164* EZH2_27294783_Chip-Seq_ESCs_Mouse0.80941804
165PHF8_20622853_ChIP-Seq_HELA_Human0.80267457
166FOXM1_26456572_ChIP-Seq_MCF-7_Human0.79717838
167SMAD4_21741376_ChIP-Seq_HESCs_Human0.79013588
168OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.77963257
169PPARA_22158963_ChIP-Seq_LIVER_Mouse0.77631006
170NFYB_21822215_ChIP-Seq_K562_Human0.77621705
171* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.77546661
172SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.77071926
173PPAR_26484153_Chip-Seq_NCI-H1993_Human0.76033220
174NANOG_19829295_ChIP-Seq_ESCs_Human0.75871025

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue4.81725231
2MP0000749_muscle_degeneration4.70338261
3MP0004145_abnormal_muscle_electrophysio4.40091302
4MP0003136_yellow_coat_color3.83517412
5MP0009379_abnormal_foot_pigmentation3.61678490
6MP0000751_myopathy3.46761731
7MP0005409_darkened_coat_color3.35396425
8MP0001188_hyperpigmentation3.06799376
9MP0004036_abnormal_muscle_relaxation2.71789794
10MP0004084_abnormal_cardiac_muscle2.61080625
11MP0005174_abnormal_tail_pigmentation2.57885042
12MP0004381_abnormal_hair_follicle2.50559986
13MP0000372_irregular_coat_pigmentation2.39687963
14MP0004215_abnormal_myocardial_fiber2.38575576
15MP0002837_dystrophic_cardiac_calcinosis2.35661432
16MP0006292_abnormal_olfactory_placode2.34958026
17MP0002106_abnormal_muscle_physiology2.23863070
18MP0005330_cardiomyopathy2.20326822
19MP0000015_abnormal_ear_pigmentation2.09085290
20MP0004233_abnormal_muscle_weight2.08455048
21MP0003828_pulmonary_edema2.03771519
22MP0005670_abnormal_white_adipose1.90445360
23MP0004147_increased_porphyrin_level1.85606113
24MP0005620_abnormal_muscle_contractility1.84924224
25MP0006036_abnormal_mitochondrial_physio1.81060996
26MP0005075_abnormal_melanosome_morpholog1.79021604
27MP0005369_muscle_phenotype1.74089412
28MP0000747_muscle_weakness1.70963082
29MP0002108_abnormal_muscle_morphology1.70794637
30MP0004484_altered_response_of1.67894154
31MP0003137_abnormal_impulse_conducting1.61741197
32MP0003724_increased_susceptibility_to1.61033635
33MP0001986_abnormal_taste_sensitivity1.60904008
34MP0002972_abnormal_cardiac_muscle1.60118076
35MP0004087_abnormal_muscle_fiber1.59704679
36MP0000759_abnormal_skeletal_muscle1.58867126
37MP0000733_abnormal_muscle_development1.53094254
38MP0002095_abnormal_skin_pigmentation1.49253915
39MP0004510_myositis1.38938093
40MP0000750_abnormal_muscle_regeneration1.38393514
41MP0000013_abnormal_adipose_tissue1.30407008
42MP0002102_abnormal_ear_morphology1.28405761
43MP0008775_abnormal_heart_ventricle1.25056722
44MP0003880_abnormal_central_pattern1.22748806
45MP0009785_altered_susceptibility_to1.22253537
46MP0000049_abnormal_middle_ear1.19741163
47MP0001661_extended_life_span1.19154143
48MP0010630_abnormal_cardiac_muscle1.15805103
49MP0002638_abnormal_pupillary_reflex1.14044676
50MP0004130_abnormal_muscle_cell1.13870404
51MP0004142_abnormal_muscle_tone1.11787523
52MP0001544_abnormal_cardiovascular_syste1.11560315
53MP0005385_cardiovascular_system_phenoty1.11560315
54MP0002148_abnormal_hypersensitivity_rea1.10017268
55MP0003221_abnormal_cardiomyocyte_apopto1.06414870
56MP0002971_abnormal_brown_adipose1.05869944
57MP0002269_muscular_atrophy1.05388632
58MP0005666_abnormal_adipose_tissue1.04376490
59MP0008260_abnormal_autophagy1.02735736
60MP0005671_abnormal_response_to1.01993797
61MP0000681_abnormal_thyroid_gland1.01195535
62MP0002177_abnormal_outer_ear1.00870829
63MP0005451_abnormal_body_composition1.00108013
64MP0002127_abnormal_cardiovascular_syste0.99875356
65MP0006035_abnormal_mitochondrial_morpho0.98964041
66MP0003567_abnormal_fetal_cardiomyocyte0.98578746
67MP0001835_abnormal_antigen_presentation0.98202974
68MP0002938_white_spotting0.97089162
69MP0004085_abnormal_heartbeat0.96736323
70MP0003763_abnormal_thymus_physiology0.95513515
71MP0002332_abnormal_exercise_endurance0.94449706
72MP0004270_analgesia0.93915589
73MP0002249_abnormal_larynx_morphology0.91630034
74MP0002876_abnormal_thyroid_physiology0.89885634
75MP0005171_absent_coat_pigmentation0.89524546
76MP0005375_adipose_tissue_phenotype0.88869294
77MP0000266_abnormal_heart_morphology0.86136262
78MP0000685_abnormal_immune_system0.85811121
79MP0006138_congestive_heart_failure0.84854407
80MP0001853_heart_inflammation0.82163837
81MP0005025_abnormal_response_to0.80742592
82MP0005165_increased_susceptibility_to0.80628282
83MP0000343_altered_response_to0.80504429
84MP0002396_abnormal_hematopoietic_system0.80453552
85MP0003950_abnormal_plasma_membrane0.79973294
86MP0009780_abnormal_chondrocyte_physiolo0.76227760
87MP0000003_abnormal_adipose_tissue0.74854079
88MP0003045_fibrosis0.74034211
89MP0002132_abnormal_respiratory_system0.73872619
90MP0000490_abnormal_crypts_of0.73091727
91MP0000465_gastrointestinal_hemorrhage0.70615637
92MP0002009_preneoplasia0.69800345
93MP0001905_abnormal_dopamine_level0.69062818
94MP0004185_abnormal_adipocyte_glucose0.66688639
95MP0002933_joint_inflammation0.65213894
96MP0008058_abnormal_DNA_repair0.64173412
97MP0000566_synostosis0.63593942
98MP0002751_abnormal_autonomic_nervous0.61921814
99MP0006276_abnormal_autonomic_nervous0.61364130
100MP0002128_abnormal_blood_circulation0.61059962
101MP0000631_abnormal_neuroendocrine_gland0.60897989
102MP0000230_abnormal_systemic_arterial0.60328568
103MP0008569_lethality_at_weaning0.59209963
104MP0003938_abnormal_ear_development0.59123054
105MP0003879_abnormal_hair_cell0.58507018
106MP0000026_abnormal_inner_ear0.57626004
107MP0003315_abnormal_perineum_morphology0.57613653
108MP0002277_abnormal_respiratory_mucosa0.57301194
109MP0009333_abnormal_splenocyte_physiolog0.56861181
110MP0001299_abnormal_eye_distance/0.56819049
111MP0005266_abnormal_metabolism0.56116743
112MP0009250_abnormal_appendicular_skeleto0.54534760
113MP0005000_abnormal_immune_tolerance0.53278861
114MP0002723_abnormal_immune_serum0.53159019
115MP0010368_abnormal_lymphatic_system0.52985648
116MP0005595_abnormal_vascular_smooth0.52480518
117MP0002822_catalepsy0.51840499
118MP0002420_abnormal_adaptive_immunity0.48781126
119MP0008995_early_reproductive_senescence0.47726858
120MP0002078_abnormal_glucose_homeostasis0.44191377
121MP0010030_abnormal_orbit_morphology0.41406347
122MP0005584_abnormal_enzyme/coenzyme_acti0.35264571
123MP0005334_abnormal_fat_pad0.35253332
124MP0005167_abnormal_blood-brain_barrier0.34162492
125MP0009115_abnormal_fat_cell0.32933451
126MP0005535_abnormal_body_temperature0.32003705
127MP0003656_abnormal_erythrocyte_physiolo0.31242738
128MP0003279_aneurysm0.30388818
129MP0005187_abnormal_penis_morphology0.30178190
130MP0005452_abnormal_adipose_tissue0.29930600
131MP0003948_abnormal_gas_homeostasis0.28320703
132MP0005376_homeostasis/metabolism_phenot0.28318678
133MP0000767_abnormal_smooth_muscle0.28227874
134MP0000762_abnormal_tongue_morphology0.26156226
135MP0001984_abnormal_olfaction0.25038476
136MP0002234_abnormal_pharynx_morphology0.24655976
137MP0009672_abnormal_birth_weight0.24199994
138MP0004134_abnormal_chest_morphology0.24119666
139MP0001879_abnormal_lymphatic_vessel0.23785524
140MP0004924_abnormal_behavior0.23018150
141MP0005386_behavior/neurological_phenoty0.23018150
142MP0004043_abnormal_pH_regulation0.22058821
143MP0009384_cardiac_valve_regurgitation0.20860741
144MP0002114_abnormal_axial_skeleton0.20161759
145MP0005319_abnormal_enzyme/_coenzyme0.19713573
146MP0000579_abnormal_nail_morphology0.18919093
147MP0005332_abnormal_amino_acid0.17827242
148MP0003941_abnormal_skin_development0.16177332
149MP0002896_abnormal_bone_mineralization0.15738763
150MP0001784_abnormal_fluid_regulation0.15153316
151MP0002925_abnormal_cardiovascular_devel0.14816972
152MP0001614_abnormal_blood_vessel0.14557586

Predicted human phenotypes

RankGene SetZ-score
1Bundle branch block (HP:0011710)5.47974011
2Muscle hypertrophy of the lower extremities (HP:0008968)5.32577954
3Calf muscle hypertrophy (HP:0008981)5.25938087
4Type I transferrin isoform profile (HP:0003642)4.71068699
5Asymmetric septal hypertrophy (HP:0001670)4.46909666
6Nonprogressive disorder (HP:0003680)4.39455368
7Exercise-induced myalgia (HP:0003738)4.26458208
8Reduced antithrombin III activity (HP:0001976)4.12531026
9Abnormality of the left ventricular outflow tract (HP:0011103)4.06493944
10Subaortic stenosis (HP:0001682)4.06493944
11Muscle fiber inclusion bodies (HP:0100299)4.01550204
12Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.97620593
13Exercise-induced muscle cramps (HP:0003710)3.88392761
14Ulnar deviation of the wrist (HP:0003049)3.87996574
15Hepatocellular necrosis (HP:0001404)3.83467795
16Nemaline bodies (HP:0003798)3.82587202
17Difficulty running (HP:0009046)3.80350194
18Abnormality of skeletal muscle fiber size (HP:0012084)3.67601419
19Acute necrotizing encephalopathy (HP:0006965)3.63533915
20Mitochondrial inheritance (HP:0001427)3.62922803
21Sudden death (HP:0001699)3.57000202
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.55786803
23EMG: neuropathic changes (HP:0003445)3.53204806
24Increased hepatocellular lipid droplets (HP:0006565)3.50592103
25Hepatic necrosis (HP:0002605)3.48643833
26Increased connective tissue (HP:0009025)3.47953480
27Hypothermia (HP:0002045)3.43154962
28Abnormality of the calf musculature (HP:0001430)3.40946305
29Abnormal mitochondria in muscle tissue (HP:0008316)3.36269972
30Heart block (HP:0012722)3.36002401
31Type 2 muscle fiber atrophy (HP:0003554)3.35250241
32Increased variability in muscle fiber diameter (HP:0003557)3.29242096
33Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.21612827
34Abnormal protein glycosylation (HP:0012346)3.20450876
35Abnormal glycosylation (HP:0012345)3.20450876
36Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.20450876
37Abnormal protein N-linked glycosylation (HP:0012347)3.20450876
38Ventricular tachycardia (HP:0004756)3.18095353
39Abnormal atrioventricular conduction (HP:0005150)3.16587591
40Absent phalangeal crease (HP:0006109)3.16418367
41Increased CSF lactate (HP:0002490)3.15879015
42Lipid accumulation in hepatocytes (HP:0006561)3.15062393
43Exercise intolerance (HP:0003546)3.14614811
44Frequent falls (HP:0002359)3.13789354
45Atrial fibrillation (HP:0005110)3.08722505
46Generalized muscle weakness (HP:0003324)3.07738836
47Lipoatrophy (HP:0100578)3.07235136
48Distal arthrogryposis (HP:0005684)3.03807762
49Ventricular arrhythmia (HP:0004308)3.03605359
50Abnormal number of erythroid precursors (HP:0012131)3.01724471
51Renal Fanconi syndrome (HP:0001994)3.00680664
52Abnormality of cells of the erythroid lineage (HP:0012130)3.00397646
53Increased intramyocellular lipid droplets (HP:0012240)2.97828260
54Muscle fiber atrophy (HP:0100295)2.96711434
55Deformed tarsal bones (HP:0008119)2.90961858
56Supraventricular tachycardia (HP:0004755)2.87280705
57Decreased activity of mitochondrial respiratory chain (HP:0008972)2.86656025
58Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.86656025
59EMG: myopathic abnormalities (HP:0003458)2.86312260
60Progressive macrocephaly (HP:0004481)2.85329504
61Primary atrial arrhythmia (HP:0001692)2.84581961
62Malignant hyperthermia (HP:0002047)2.83103332
63Weak cry (HP:0001612)2.82605729
64Supraventricular arrhythmia (HP:0005115)2.75141920
65Right ventricular cardiomyopathy (HP:0011663)2.73270472
663-Methylglutaconic aciduria (HP:0003535)2.72458851
67Type 1 muscle fiber predominance (HP:0003803)2.71899099
68Gowers sign (HP:0003391)2.70175997
69Optic disc pallor (HP:0000543)2.66745697
70Acute encephalopathy (HP:0006846)2.66352465
71Thyroid-stimulating hormone excess (HP:0002925)2.65770924
72Dilated cardiomyopathy (HP:0001644)2.65254207
73Mildly elevated creatine phosphokinase (HP:0008180)2.62781564
74Muscle fiber splitting (HP:0003555)2.61600804
75Increased muscle lipid content (HP:0009058)2.61259129
76Abnormal finger flexion creases (HP:0006143)2.59466020
77Exertional dyspnea (HP:0002875)2.58559250
78Respiratory difficulties (HP:0002880)2.54998188
79Absent rod-and cone-mediated responses on ERG (HP:0007688)2.54418821
80Microvesicular hepatic steatosis (HP:0001414)2.49778228
81Myoglobinuria (HP:0002913)2.46778750
82Fetal akinesia sequence (HP:0001989)2.46142049
83Rhabdomyolysis (HP:0003201)2.42194540
84Increased serum lactate (HP:0002151)2.41046720
85Scapular winging (HP:0003691)2.37940331
86Lactic acidosis (HP:0003128)2.36747572
87Atrioventricular block (HP:0001678)2.35448829
88Muscular dystrophy (HP:0003560)2.32426974
89Severe visual impairment (HP:0001141)2.31941152
90Abnormality of the neuromuscular junction (HP:0003398)2.31448769
91Fatigable weakness (HP:0003473)2.31448769
92Abnormality of the foot musculature (HP:0001436)2.31167140
93Neck muscle weakness (HP:0000467)2.28048187
94Distal lower limb amyotrophy (HP:0008944)2.26929017
95Ventricular fibrillation (HP:0001663)2.23917201
96Reticulocytopenia (HP:0001896)2.23860622
97Limb-girdle muscle atrophy (HP:0003797)2.22773929
98Abnormality of the axillary hair (HP:0100134)2.21095235
99Abnormality of secondary sexual hair (HP:0009888)2.21095235
100Myopathic facies (HP:0002058)2.20873275
101Attenuation of retinal blood vessels (HP:0007843)2.20553270
102Myotonia (HP:0002486)2.18816575
103Ragged-red muscle fibers (HP:0003200)2.11890573
104Aplastic anemia (HP:0001915)2.10812758
105Popliteal pterygium (HP:0009756)2.09214783
106Respiratory failure (HP:0002878)2.09155392
107Muscle stiffness (HP:0003552)2.06010897
108Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.05735992
109Abnormality of alanine metabolism (HP:0010916)2.05735992
110Hyperalaninemia (HP:0003348)2.05735992
111Prolonged QT interval (HP:0001657)2.05651742
112Foot dorsiflexor weakness (HP:0009027)2.05568714
113Areflexia of lower limbs (HP:0002522)2.05285082
114Difficulty climbing stairs (HP:0003551)2.02395523
115Hip contracture (HP:0003273)2.02281017
116Round ear (HP:0100830)2.01863022
117Rimmed vacuoles (HP:0003805)2.01125604
118Proximal amyotrophy (HP:0007126)2.00695757
119Abnormality of the shoulder girdle musculature (HP:0001435)1.98131075
120Hyporeflexia of lower limbs (HP:0002600)1.96694132
121Respiratory insufficiency due to muscle weakness (HP:0002747)1.95908634
122Slender build (HP:0001533)1.94253735
123Palpitations (HP:0001962)1.93260246
124Cerebral edema (HP:0002181)1.92700677
125Hyperkalemia (HP:0002153)1.90654224
126Spinal rigidity (HP:0003306)1.89861846
127Distal lower limb muscle weakness (HP:0009053)1.86260968
128Waddling gait (HP:0002515)1.85812195
129True hermaphroditism (HP:0010459)1.85562917
130Abnormality of renal resorption (HP:0011038)1.85175028
131Left ventricular hypertrophy (HP:0001712)1.80815818
132Progressive muscle weakness (HP:0003323)1.80771454
133Oligomenorrhea (HP:0000876)1.80542487
134Steppage gait (HP:0003376)1.79784132
135Syncope (HP:0001279)1.78814144
136Abnormality of the heme biosynthetic pathway (HP:0010472)1.76204979
137Abnormality of the calcaneus (HP:0008364)1.75893890
138Bulbar palsy (HP:0001283)1.71029201
139Toxemia of pregnancy (HP:0100603)1.70787606
140Abnormal EKG (HP:0003115)1.69022152
141Centrally nucleated skeletal muscle fibers (HP:0003687)1.68410572
142Aplasia/Hypoplasia of the sacrum (HP:0008517)1.68193730
143Calcaneovalgus deformity (HP:0001848)1.67842393
144Lower limb amyotrophy (HP:0007210)1.66141623
145Palmoplantar keratoderma (HP:0000982)1.64431793
146Abnormality of the musculature of the pelvis (HP:0001469)1.60185773
147Abnormality of the hip-girdle musculature (HP:0001445)1.60185773
148Limb-girdle muscle weakness (HP:0003325)1.58890137
149Aplasia of the musculature (HP:0100854)1.55568742
150Facial diplegia (HP:0001349)1.50094682

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK6.21320874
2MUSK5.96529978
3OBSCN4.85922015
4CASK2.96008444
5NME22.90145550
6STK162.86407700
7NLK2.62035738
8MKNK22.40321428
9PHKG12.12990262
10PHKG22.12990262
11MYLK2.10740189
12EIF2AK31.85671133
13ZAK1.73192407
14MKNK11.62700606
15TEC1.56010438
16LIMK11.50682175
17PDK21.47881081
18STK241.46276318
19KIT1.45577932
20TIE11.42778242
21SRPK11.36672007
22PIK3CA1.35952218
23CAMK11.33709402
24EIF2AK21.33541979
25PIK3CG1.24978777
26MARK11.18223960
27IRAK41.17152540
28CAMKK21.16916465
29MAP2K71.16172828
30CLK11.14914362
31GRK71.13391849
32TLK11.11453729
33PINK11.11219885
34NME11.11171228
35ADRBK21.10748784
36MAPK131.07271476
37CDK191.05891871
38MAP2K31.05649476
39VRK11.03704228
40NEK11.01497929
41NEK90.99959215
42FES0.99202245
43TRPM70.96402594
44TTN0.96325420
45MAPKAPK50.94979979
46BRSK20.93740345
47IRAK30.92585972
48YES10.92118166
49CCNB10.86921848
50PIM20.85945434
51PRKAA10.85428555
52ROCK10.81254161
53MAP2K40.81089062
54FLT30.80802165
55BCKDK0.79900918
56WEE10.78806047
57MAPK120.77756781
58BTK0.77735456
59PRKAA20.75806701
60ERBB30.75686329
61TXK0.75051140
62MAP3K120.74094004
63MAPKAPK30.73661314
64BLK0.70614788
65PAK30.67758903
66BMPR1B0.66972353
67MAPK70.64588558
68MOS0.61408739
69GRK10.60137514
70EEF2K0.60098175
71PRKG20.59244003
72IKBKB0.58471748
73PRKD10.58156713
74MAP3K70.57492676
75CAMK2D0.56484997
76KDR0.56348574
77CDK30.56324849
78AKT20.54227090
79TGFBR20.52758788
80MAP2K60.52717396
81MAP2K10.50719603
82PRKD20.50577207
83MAPK40.50401122
84STK390.49317505
85DYRK30.47881676
86IKBKE0.47032083
87MAP3K50.43823665
88MAPK150.43521322
89EPHA30.43251433
90ILK0.43117719
91IRAK10.42907646
92LYN0.40721633
93BMPR20.40663367
94RPS6KA50.39704949
95PRKG10.39103787
96RIPK10.38974993
97MAP3K60.38418305
98CSNK1G10.37317991
99DMPK0.36992400
100INSRR0.36754723
101ROCK20.36457823
102DYRK1B0.36165735
103TRIB30.35527796
104PKN10.35498870
105MATK0.34294289
106CDK80.34074997
107LATS20.33406272
108CAMK40.33086053
109MAP3K130.32640764
110PRKACG0.32555234
111NEK60.31230845
112PRKACA0.31137041
113SGK30.30694818
114SYK0.30508498
115STK38L0.30241073
116TNK20.29601803
117RPS6KA30.29514957
118MAPK110.29408519
119CAMK2B0.28916202
120TBK10.28728233
121IRAK20.28666474
122PRKACB0.28004087
123SGK20.27534214
124CAMK2A0.27073703
125CSF1R0.26766442
126HIPK20.26599614
127RPS6KA10.26476896
128CSNK2A10.25838453
129KSR20.25107977
130ACVR1B0.24392488
131MAP3K140.24282986
132RPS6KL10.23538011
133RPS6KC10.23538011
134CAMK2G0.23490392
135PDPK10.23373682
136DYRK20.23157986
137PRKCE0.22697645
138RPS6KA60.20472256
139MAPK100.18717450
140PDK10.18264346
141CDC42BPA0.17967732
142STK110.17825244
143RAF10.16171340
144LATS10.15732369
145SGK10.15445424
146STK40.15172292
147EPHB10.14475941
148PKN20.13382427
149RPS6KB10.11596449
150MARK20.11565385
151MARK30.11031045
152MTOR0.09994181
153WNK10.09952227
154FGFR30.07028600
155SGK2230.05645292
156SGK4940.05645292
157PRKDC0.04618617
158ZAP700.04197930
159DAPK30.03516099
160PTK2B0.03440444

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.39025717
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.13239672
3Oxidative phosphorylation_Homo sapiens_hsa001903.95117895
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.87008312
5Parkinsons disease_Homo sapiens_hsa050123.63570736
6Cardiac muscle contraction_Homo sapiens_hsa042603.42024867
7Alzheimers disease_Homo sapiens_hsa050102.68519591
8Protein export_Homo sapiens_hsa030602.54197035
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.53992425
10Huntingtons disease_Homo sapiens_hsa050162.50298393
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.45571204
12DNA replication_Homo sapiens_hsa030302.37120538
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.34424439
14Homologous recombination_Homo sapiens_hsa034402.14360596
15RNA polymerase_Homo sapiens_hsa030202.11916088
16Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.07141371
17Carbon metabolism_Homo sapiens_hsa012002.01432885
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.94818085
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.84792952
20Pyruvate metabolism_Homo sapiens_hsa006201.76641471
21Glucagon signaling pathway_Homo sapiens_hsa049221.71326255
22Dilated cardiomyopathy_Homo sapiens_hsa054141.70866122
23Proteasome_Homo sapiens_hsa030501.70865566
24Pyrimidine metabolism_Homo sapiens_hsa002401.66649125
25Fatty acid degradation_Homo sapiens_hsa000711.59750530
26Insulin signaling pathway_Homo sapiens_hsa049101.58155060
27Arginine and proline metabolism_Homo sapiens_hsa003301.56123894
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.54017488
29Fanconi anemia pathway_Homo sapiens_hsa034601.48292707
30Mismatch repair_Homo sapiens_hsa034301.48097292
31Arginine biosynthesis_Homo sapiens_hsa002201.46305847
32Purine metabolism_Homo sapiens_hsa002301.45821172
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.45154021
34Insulin resistance_Homo sapiens_hsa049311.45044497
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.40140032
36Base excision repair_Homo sapiens_hsa034101.34499588
37Phenylalanine metabolism_Homo sapiens_hsa003601.28270120
38Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.28209754
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.28133725
40Fatty acid elongation_Homo sapiens_hsa000621.26833511
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.26650228
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.21441675
43Fatty acid metabolism_Homo sapiens_hsa012121.19708595
44Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.19581256
45Arachidonic acid metabolism_Homo sapiens_hsa005901.18667492
46Pentose phosphate pathway_Homo sapiens_hsa000301.18084837
47Phototransduction_Homo sapiens_hsa047441.17376805
48Adipocytokine signaling pathway_Homo sapiens_hsa049201.16410370
49Basal transcription factors_Homo sapiens_hsa030221.13461459
50Renin secretion_Homo sapiens_hsa049241.13138105
51Nucleotide excision repair_Homo sapiens_hsa034201.12921966
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.12056485
53Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.09434856
54PPAR signaling pathway_Homo sapiens_hsa033201.09324466
55AMPK signaling pathway_Homo sapiens_hsa041521.09100274
56Primary immunodeficiency_Homo sapiens_hsa053401.08737333
57Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.07047691
58Non-homologous end-joining_Homo sapiens_hsa034501.03334238
59RNA degradation_Homo sapiens_hsa030180.98977201
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.98185570
61Biosynthesis of amino acids_Homo sapiens_hsa012300.96735738
62Calcium signaling pathway_Homo sapiens_hsa040200.95124124
63Allograft rejection_Homo sapiens_hsa053300.93886013
64Asthma_Homo sapiens_hsa053100.92574702
65Spliceosome_Homo sapiens_hsa030400.91583769
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89305897
67Other glycan degradation_Homo sapiens_hsa005110.88455560
68Tight junction_Homo sapiens_hsa045300.88441874
69Hematopoietic cell lineage_Homo sapiens_hsa046400.88149650
70Thyroid cancer_Homo sapiens_hsa052160.87554392
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.87224978
72Fructose and mannose metabolism_Homo sapiens_hsa000510.86839694
73N-Glycan biosynthesis_Homo sapiens_hsa005100.84770249
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81223306
75Sphingolipid metabolism_Homo sapiens_hsa006000.81181608
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80521186
77Gastric acid secretion_Homo sapiens_hsa049710.75319693
78NF-kappa B signaling pathway_Homo sapiens_hsa040640.75156659
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74829343
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74629687
81Measles_Homo sapiens_hsa051620.73817293
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71760306
83Sulfur relay system_Homo sapiens_hsa041220.71685497
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70553256
85Focal adhesion_Homo sapiens_hsa045100.69687892
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.69076526
87Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.67925786
88Insulin secretion_Homo sapiens_hsa049110.66794781
89Metabolic pathways_Homo sapiens_hsa011000.66309303
90Herpes simplex infection_Homo sapiens_hsa051680.65931460
91Butanoate metabolism_Homo sapiens_hsa006500.64945134
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.64112792
93Tryptophan metabolism_Homo sapiens_hsa003800.63087213
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62233644
95Circadian entrainment_Homo sapiens_hsa047130.60949960
96Ether lipid metabolism_Homo sapiens_hsa005650.60401215
97Autoimmune thyroid disease_Homo sapiens_hsa053200.58975231
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56810357
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56689965
100cAMP signaling pathway_Homo sapiens_hsa040240.56274505
101Malaria_Homo sapiens_hsa051440.56055392
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55497096
103Nitrogen metabolism_Homo sapiens_hsa009100.55445745
104Circadian rhythm_Homo sapiens_hsa047100.53078781
105Graft-versus-host disease_Homo sapiens_hsa053320.52754220
106Linoleic acid metabolism_Homo sapiens_hsa005910.51147316
107GnRH signaling pathway_Homo sapiens_hsa049120.50460169
108Starch and sucrose metabolism_Homo sapiens_hsa005000.49881132
109Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.47469871
110Propanoate metabolism_Homo sapiens_hsa006400.47001042
111Serotonergic synapse_Homo sapiens_hsa047260.44761288
112Leishmaniasis_Homo sapiens_hsa051400.43795832
113Ovarian steroidogenesis_Homo sapiens_hsa049130.43419039
114beta-Alanine metabolism_Homo sapiens_hsa004100.42454149
115Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41282897
116Salivary secretion_Homo sapiens_hsa049700.41018705
117Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.40908961
118Olfactory transduction_Homo sapiens_hsa047400.40796214
119Acute myeloid leukemia_Homo sapiens_hsa052210.39822882
120Pancreatic secretion_Homo sapiens_hsa049720.39725548
121Galactose metabolism_Homo sapiens_hsa000520.38654431
122Long-term potentiation_Homo sapiens_hsa047200.37887650
123Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.37489352
124Adherens junction_Homo sapiens_hsa045200.37142640
125FoxO signaling pathway_Homo sapiens_hsa040680.36988058
126Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35089223
127p53 signaling pathway_Homo sapiens_hsa041150.34926369
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.34480095
129Tyrosine metabolism_Homo sapiens_hsa003500.34405184
130Fatty acid biosynthesis_Homo sapiens_hsa000610.33655609
131Taste transduction_Homo sapiens_hsa047420.33100405
132Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32637046
133Lysine degradation_Homo sapiens_hsa003100.32333417
134Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32107471
135cGMP-PKG signaling pathway_Homo sapiens_hsa040220.31757571
136Peroxisome_Homo sapiens_hsa041460.31344605
137Regulation of autophagy_Homo sapiens_hsa041400.31247913
138Folate biosynthesis_Homo sapiens_hsa007900.30099502
139Viral myocarditis_Homo sapiens_hsa054160.28457507
140alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27666644
141Cholinergic synapse_Homo sapiens_hsa047250.26748807
142Bile secretion_Homo sapiens_hsa049760.25557758
143Oxytocin signaling pathway_Homo sapiens_hsa049210.25504303
144ECM-receptor interaction_Homo sapiens_hsa045120.24339583
145Platelet activation_Homo sapiens_hsa046110.23524992
146MAPK signaling pathway_Homo sapiens_hsa040100.22830484
147Gap junction_Homo sapiens_hsa045400.22030053
148Wnt signaling pathway_Homo sapiens_hsa043100.21083875
149B cell receptor signaling pathway_Homo sapiens_hsa046620.21044492
150Toll-like receptor signaling pathway_Homo sapiens_hsa046200.20961024
151Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.20349309
152NOD-like receptor signaling pathway_Homo sapiens_hsa046210.18796283
153Amphetamine addiction_Homo sapiens_hsa050310.18653702
154Systemic lupus erythematosus_Homo sapiens_hsa053220.18383632
155Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.18356205
156ABC transporters_Homo sapiens_hsa020100.18078403
157Pertussis_Homo sapiens_hsa051330.17636693
158HIF-1 signaling pathway_Homo sapiens_hsa040660.17298936
159Cysteine and methionine metabolism_Homo sapiens_hsa002700.16991828
160Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.16322549
161Histidine metabolism_Homo sapiens_hsa003400.15413715
162Rheumatoid arthritis_Homo sapiens_hsa053230.14436174
163Amoebiasis_Homo sapiens_hsa051460.14077944
164mTOR signaling pathway_Homo sapiens_hsa041500.13983850
165Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.13943753
166Epstein-Barr virus infection_Homo sapiens_hsa051690.13934071
167Leukocyte transendothelial migration_Homo sapiens_hsa046700.13814650
168Dorso-ventral axis formation_Homo sapiens_hsa043200.11202810
169Glycerophospholipid metabolism_Homo sapiens_hsa005640.09944683
170Melanogenesis_Homo sapiens_hsa049160.07661107

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