KLHL24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a ubiquitin ligase substrate receptor and is regulated by autoubiquitination. Variations in the translation initiation codon of this gene have been found, which result in an N-terminally truncated but more stable protein due to loss of the autoubiquitination function. The more stable mutant protein causes an increased ubiquitin and degradation of keratin 14, which leads to skin fragility and the potentially life-threatening disease epidermolysis bullosa. The encoded protein is also involved in the regulation of kainate receptors. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid transmembrane transport (GO:1902001)4.29128694
2carnitine shuttle (GO:0006853)4.21831695
3positive regulation of fatty acid beta-oxidation (GO:0032000)4.16721177
4negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.15980986
5cardiac myofibril assembly (GO:0055003)4.04440883
6neural tube formation (GO:0001841)3.97315105
7response to inactivity (GO:0014854)3.79131285
8limb bud formation (GO:0060174)3.73368054
9regulation of relaxation of muscle (GO:1901077)3.72393152
10sarcomere organization (GO:0045214)3.70795278
11positive regulation of fatty acid oxidation (GO:0046321)3.70474109
12myofibril assembly (GO:0030239)3.64756324
13regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.59971880
14pyrimidine nucleobase catabolic process (GO:0006208)3.55066225
15negative regulation of potassium ion transmembrane transport (GO:1901380)3.49724403
16regulation of sequestering of triglyceride (GO:0010889)3.49520210
17regulation of sarcomere organization (GO:0060297)3.49491306
18negative regulation of cytosolic calcium ion concentration (GO:0051481)3.47885264
19regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.45403199
202-oxoglutarate metabolic process (GO:0006103)3.44559173
21regulation of fatty acid oxidation (GO:0046320)3.43003772
22positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.41137538
23regulation of fatty acid beta-oxidation (GO:0031998)3.39225633
24regulation of skeletal muscle contraction (GO:0014819)3.34247799
25fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.31481136
26cardiac ventricle formation (GO:0003211)3.31145936
27muscle filament sliding (GO:0030049)3.31063906
28actin-myosin filament sliding (GO:0033275)3.31063906
29regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.29628536
30cardiac muscle hypertrophy (GO:0003300)3.28971016
31cardiac chamber formation (GO:0003207)3.26740594
32membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.25156753
33fatty acid beta-oxidation (GO:0006635)3.23988129
34antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.23649168
35carnitine transmembrane transport (GO:1902603)3.21507436
36phospholipid homeostasis (GO:0055091)3.21185248
37interkinetic nuclear migration (GO:0022027)3.14001940
38striated muscle hypertrophy (GO:0014897)3.12560981
39insulin-like growth factor receptor signaling pathway (GO:0048009)3.12254961
40positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.10623345
41positive regulation of glycogen biosynthetic process (GO:0045725)3.08419071
42adult heart development (GO:0007512)3.07913106
43carnitine metabolic process (GO:0009437)3.05945705
44valine metabolic process (GO:0006573)3.05625201
45cardiac muscle contraction (GO:0060048)3.04028476
46amino-acid betaine transport (GO:0015838)2.98716274
47carnitine transport (GO:0015879)2.98716274
48regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.98495027
49regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.97850113
50alpha-linolenic acid metabolic process (GO:0036109)2.94723574
51positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.93835704
52actin-mediated cell contraction (GO:0070252)2.92719539
53negative regulation of heart growth (GO:0061117)2.92109984
54negative regulation of cardiac muscle tissue growth (GO:0055022)2.92109984
55regulation of cell communication by electrical coupling (GO:0010649)2.88089057
56fatty acid oxidation (GO:0019395)2.86117631
57lipid oxidation (GO:0034440)2.84885724
58lysine metabolic process (GO:0006553)2.84294327
59lysine catabolic process (GO:0006554)2.84294327
60central nervous system projection neuron axonogenesis (GO:0021952)2.84153292
61nucleobase catabolic process (GO:0046113)2.83772688
62muscle hypertrophy (GO:0014896)2.83211052
63regulation of acyl-CoA biosynthetic process (GO:0050812)2.82837509
64nucleus localization (GO:0051647)2.80345448
65establishment of protein localization to Golgi (GO:0072600)2.79849514
66tricarboxylic acid cycle (GO:0006099)2.79552847
67regulation of actin filament-based movement (GO:1903115)2.79334211
68nerve growth factor signaling pathway (GO:0038180)2.78779871
69relaxation of cardiac muscle (GO:0055119)2.77888899
70tricarboxylic acid metabolic process (GO:0072350)2.76427983
71positive regulation of glycogen metabolic process (GO:0070875)2.75738596
72presynaptic membrane assembly (GO:0097105)2.75621213
73fatty acid homeostasis (GO:0055089)2.75420227
74neuronal action potential propagation (GO:0019227)2.72955946
75growth hormone receptor signaling pathway (GO:0060396)2.72881927
76cerebellar Purkinje cell differentiation (GO:0021702)2.72316128
77fatty acid catabolic process (GO:0009062)2.71615634
78macroautophagy (GO:0016236)2.71532983
79short-chain fatty acid metabolic process (GO:0046459)2.69340519
80presynaptic membrane organization (GO:0097090)2.69277674
81behavioral response to nicotine (GO:0035095)2.68972830
82positive regulation of action potential (GO:0045760)2.68826418
83actin filament-based movement (GO:0030048)2.68301984
84amino-acid betaine metabolic process (GO:0006577)2.68083912
85positive regulation of gamma-delta T cell activation (GO:0046645)2.67336761
86positive regulation of glycolytic process (GO:0045821)2.66789514
87cytoplasmic mRNA processing body assembly (GO:0033962)2.66709990
88regulation of action potential (GO:0098900)2.64738810
89protein targeting to Golgi (GO:0000042)2.64689158
90regulation of membrane repolarization (GO:0060306)2.63551364
91striated muscle contraction (GO:0006941)2.63428594
92actomyosin structure organization (GO:0031032)2.62760930
93intracellular lipid transport (GO:0032365)2.61021759
94phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.60638521
95response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.58856921
96membrane depolarization during action potential (GO:0086010)2.57601324
97cardiac muscle hypertrophy in response to stress (GO:0014898)2.57007982
98muscle hypertrophy in response to stress (GO:0003299)2.57007982
99cardiac muscle adaptation (GO:0014887)2.57007982
100negative regulation of neurotransmitter transport (GO:0051589)2.56898480
101retrograde transport, vesicle recycling within Golgi (GO:0000301)2.55697262
102sarcoplasmic reticulum calcium ion transport (GO:0070296)2.55676624
103central nervous system neuron axonogenesis (GO:0021955)2.55004825
104dicarboxylic acid biosynthetic process (GO:0043650)2.54697998
105neurotransmitter-gated ion channel clustering (GO:0072578)2.54142891
106acetyl-CoA metabolic process (GO:0006084)2.52600022
107axonal fasciculation (GO:0007413)2.52479872
108positive regulation of histone deacetylation (GO:0031065)2.51180382
109behavioral response to ethanol (GO:0048149)2.49567330
110biotin metabolic process (GO:0006768)2.46796238
111neuron recognition (GO:0008038)2.46724233
112positive regulation of lipid catabolic process (GO:0050996)2.45979519
113venous blood vessel morphogenesis (GO:0048845)2.44598444
114somite development (GO:0061053)2.44558599
115lymph vessel development (GO:0001945)2.42208209
116glycogen catabolic process (GO:0005980)2.41877962
117regulation of calcium ion transmembrane transporter activity (GO:1901019)2.41344300
118regulation of calcium ion transmembrane transport (GO:1903169)2.41344300
119regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.41253042
120regulation of glucose import in response to insulin stimulus (GO:2001273)2.40504045
121skeletal muscle contraction (GO:0003009)2.40405752
122regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.40050191
123monocarboxylic acid catabolic process (GO:0072329)2.39971306
124regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.39960708
125regulation of striated muscle contraction (GO:0006942)2.39658939
126plasma membrane repair (GO:0001778)2.39471031
127ethanol oxidation (GO:0006069)2.39439472
128epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.38477480
129inner ear receptor stereocilium organization (GO:0060122)2.38457906
130detection of calcium ion (GO:0005513)2.38451277
131regulation of collateral sprouting (GO:0048670)2.38432510
132gap junction assembly (GO:0016264)2.38227887
133neuronal action potential (GO:0019228)2.37609634
134positive regulation of B cell differentiation (GO:0045579)2.37596599
135cell migration in hindbrain (GO:0021535)2.37166656
136regulation of energy homeostasis (GO:2000505)2.36197252
137glial cell proliferation (GO:0014009)2.36182930
138cell communication by electrical coupling (GO:0010644)2.35816490
139regulation of NFAT protein import into nucleus (GO:0051532)2.33976736
140cardiac muscle cell development (GO:0055013)2.33737938
141striated muscle adaptation (GO:0014888)2.31392858
142complement activation, alternative pathway (GO:0006957)2.31131258
143sympathetic nervous system development (GO:0048485)2.30896308
144regulation of cofactor metabolic process (GO:0051193)2.30640269
145regulation of coenzyme metabolic process (GO:0051196)2.30640269
146regulation of tight junction assembly (GO:2000810)2.30569853
147cAMP catabolic process (GO:0006198)2.28739871
148regulation of cardiac muscle cell contraction (GO:0086004)2.28621526
149protein K11-linked deubiquitination (GO:0035871)2.28015411
150regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.26925442
151positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.26634893
152mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.26634893
153positive regulation of cardiac muscle cell differentiation (GO:2000727)2.24733791
154cornea development in camera-type eye (GO:0061303)2.24684907
155positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.24402001
156establishment of nucleus localization (GO:0040023)2.24220619
157positive regulation of cation channel activity (GO:2001259)2.24050075
158regulation of protein glycosylation (GO:0060049)2.23342040
159epithelial cell differentiation involved in kidney development (GO:0035850)2.23169264
160L-fucose catabolic process (GO:0042355)2.22867840
161fucose catabolic process (GO:0019317)2.22867840
162L-fucose metabolic process (GO:0042354)2.22867840
163negative regulation of neurotransmitter secretion (GO:0046929)2.22798950
164dendrite morphogenesis (GO:0048813)2.19942850
165cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.19685888
166regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.17900627
167cyclic nucleotide catabolic process (GO:0009214)2.17233409

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.03602859
2EZH2_22144423_ChIP-Seq_EOC_Human3.64920793
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.75322777
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.72782771
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.50637248
6GATA1_22025678_ChIP-Seq_K562_Human2.48880908
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.41699613
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.28831055
9LXR_22158963_ChIP-Seq_LIVER_Mouse2.21880057
10IGF1R_20145208_ChIP-Seq_DFB_Human2.21193553
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.18110791
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.17045566
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.14410705
14ESR1_20079471_ChIP-ChIP_T-47D_Human2.13306050
15EP300_21415370_ChIP-Seq_HL-1_Mouse2.10453439
16NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.03287202
17RXR_22158963_ChIP-Seq_LIVER_Mouse1.98007486
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92742401
19VDR_22108803_ChIP-Seq_LS180_Human1.92681953
20SMAD_19615063_ChIP-ChIP_OVARY_Human1.90276080
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80842976
22PPARA_22158963_ChIP-Seq_LIVER_Mouse1.79827465
23EGR1_23403033_ChIP-Seq_LIVER_Mouse1.78071559
24ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.77679045
25CLOCK_20551151_ChIP-Seq_293T_Human1.75933374
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.73738541
27RUNX_20019798_ChIP-Seq_JUKART_Human1.71421149
28FUS_26573619_Chip-Seq_HEK293_Human1.70658482
29RBPJ_22232070_ChIP-Seq_NCS_Mouse1.70592001
30* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.69701925
31* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.67189847
32ZNF217_24962896_ChIP-Seq_MCF-7_Human1.65402956
33ZNF274_21170338_ChIP-Seq_K562_Hela1.60515665
34SALL1_21062744_ChIP-ChIP_HESCs_Human1.59190916
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.56765213
36PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.54247646
37FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.54139828
38ARNT_22903824_ChIP-Seq_MCF-7_Human1.53950969
39AHR_22903824_ChIP-Seq_MCF-7_Human1.50864737
40TBX20_22328084_ChIP-Seq_HEART_Mouse1.50210558
41TBX20_22080862_ChIP-Seq_HEART_Mouse1.50210558
42TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49139314
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.48569855
44AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.48511038
45Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.48369492
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48304983
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.48038741
48NRF2_20460467_ChIP-Seq_MEFs_Mouse1.47834402
49NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.47834402
50GBX2_23144817_ChIP-Seq_PC3_Human1.47548929
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.47026906
52TCF4_18268006_ChIP-ChIP_LS174T_Human1.46173774
53TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45127125
54TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43713940
55POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43713940
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43108285
57TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.43041321
58STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.42669898
59BCAT_22108803_ChIP-Seq_LS180_Human1.41894859
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.41044649
61FOXA2_19822575_ChIP-Seq_HepG2_Human1.40853758
62* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.38623177
63RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36983054
64HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.36780490
65TP53_16413492_ChIP-PET_HCT116_Human1.35642640
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.34437239
67NANOG_18555785_Chip-Seq_ESCs_Mouse1.33450864
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33408617
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33177437
70EZH2_27294783_Chip-Seq_NPCs_Mouse1.32839090
71TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32668391
72WT1_19549856_ChIP-ChIP_CCG9911_Human1.32043313
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31511472
74IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30800017
75CBP_20019798_ChIP-Seq_JUKART_Human1.30800017
76GATA2_21666600_ChIP-Seq_HMVEC_Human1.29987270
77CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.25745426
78EGR1_19374776_ChIP-ChIP_THP-1_Human1.24768283
79TAF15_26573619_Chip-Seq_HEK293_Human1.22882382
80PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21591310
81FLI1_21867929_ChIP-Seq_TH2_Mouse1.21258941
82EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.19895271
83EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19847200
84RNF2_27304074_Chip-Seq_NSC_Mouse1.19682588
85AR_21572438_ChIP-Seq_LNCaP_Human1.18064360
86EWS_26573619_Chip-Seq_HEK293_Human1.17605059
87TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17559530
88VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17237310
89E2F1_18555785_Chip-Seq_ESCs_Mouse1.16026767
90P53_22387025_ChIP-Seq_ESCs_Mouse1.15890009
91SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.15779680
92NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15399691
93RUNX2_22187159_ChIP-Seq_PCA_Human1.15044448
94TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14091242
95NFE2_27457419_Chip-Seq_LIVER_Mouse1.13445237
96REST_21632747_ChIP-Seq_MESCs_Mouse1.13265203
97RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.13256718
98CTNNB1_20460455_ChIP-Seq_HCT116_Human1.12779322
99SOX2_21211035_ChIP-Seq_LN229_Gbm1.12755127
100CJUN_26792858_Chip-Seq_BT549_Human1.12647452
101PPAR_26484153_Chip-Seq_NCI-H1993_Human1.12370838
102DROSHA_22980978_ChIP-Seq_HELA_Human1.12310209
103PRDM14_20953172_ChIP-Seq_ESCs_Human1.10045219
104RXR_22108803_ChIP-Seq_LS180_Human1.09725206
105* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.09295202
106SMAD4_21799915_ChIP-Seq_A2780_Human1.08618467
107VDR_24787735_ChIP-Seq_THP-1_Human1.08586398
108FOXO3_23340844_ChIP-Seq_DLD1_Human1.08286697
109OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07115188
110TCF4_22108803_ChIP-Seq_LS180_Human1.06884941
111PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06143462
112* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06061210
113FOXM1_26456572_ChIP-Seq_MCF-7_Human1.05930260
114CRX_20693478_ChIP-Seq_RETINA_Mouse1.05852145
115SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05449930
116OCT4_21477851_ChIP-Seq_ESCs_Mouse1.04661570
117* P300_19829295_ChIP-Seq_ESCs_Human1.04374982
118SMAD3_21741376_ChIP-Seq_HESCs_Human1.04363563
119AR_25329375_ChIP-Seq_VCAP_Human1.03505684
120SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.02774347
121JARID2_20064375_ChIP-Seq_MESCs_Mouse1.02520502
122LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02202110
123TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01604293
124SUZ12_18555785_Chip-Seq_ESCs_Mouse1.01601471
125KDM2B_26808549_Chip-Seq_REH_Human1.01242947
126IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.01077273
127CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.00967071
128TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00825684
129* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98764870
130ISL1_27105846_Chip-Seq_CPCs_Mouse0.98476742
131PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.96945406
132STAT3_23295773_ChIP-Seq_U87_Human0.96884079
133TCF4_23295773_ChIP-Seq_U87_Human0.94933340
134TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.94812993
135FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94625703
136DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94075951
137* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.93853456
138CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.92555187
139ER_23166858_ChIP-Seq_MCF-7_Human0.92162348
140SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91380273
141TP53_18474530_ChIP-ChIP_U2OS_Human0.91304830
142NR3C1_23031785_ChIP-Seq_PC12_Mouse0.88356683
143AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.87725455
144HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.86650336
145* STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.85698677
146NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.85641884
147FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.85541354
148FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.84367320
149SMAD3_21741376_ChIP-Seq_EPCs_Human0.84093792
150* IRF8_27001747_Chip-Seq_BMDM_Mouse0.83721493
151WT1_25993318_ChIP-Seq_PODOCYTE_Human0.82951531
152SOX9_24532713_ChIP-Seq_HFSC_Mouse0.82363847

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.20301132
2MP0004130_abnormal_muscle_cell3.98537238
3MP0004084_abnormal_cardiac_muscle3.41219719
4MP0003646_muscle_fatigue3.37408239
5MP0004215_abnormal_myocardial_fiber3.25285372
6MP0004036_abnormal_muscle_relaxation2.90286642
7MP0000751_myopathy2.70137221
8MP0009780_abnormal_chondrocyte_physiolo2.59328326
9MP0002822_catalepsy2.56402550
10MP0001879_abnormal_lymphatic_vessel2.54173525
11MP0004270_analgesia2.53363000
12MP0002139_abnormal_hepatobiliary_system2.51576991
13MP0002166_altered_tumor_susceptibility2.44958869
14MP0000749_muscle_degeneration2.39980674
15MP0002009_preneoplasia2.37500720
16MP0002638_abnormal_pupillary_reflex2.36779195
17MP0002972_abnormal_cardiac_muscle2.32731332
18MP0005670_abnormal_white_adipose2.29436932
19MP0003880_abnormal_central_pattern2.24753901
20MP0004087_abnormal_muscle_fiber2.22880549
21MP0005365_abnormal_bile_salt2.13553022
22MP0005360_urolithiasis2.13419682
23MP0005330_cardiomyopathy2.12117572
24MP0010630_abnormal_cardiac_muscle2.07878015
25MP0005620_abnormal_muscle_contractility2.07397342
26MP0005085_abnormal_gallbladder_physiolo2.05154687
27MP0010368_abnormal_lymphatic_system2.00827540
28MP0005187_abnormal_penis_morphology1.93027401
29MP0006276_abnormal_autonomic_nervous1.86157155
30MP0005385_cardiovascular_system_phenoty1.82498845
31MP0001544_abnormal_cardiovascular_syste1.82498845
32MP0001984_abnormal_olfaction1.81760136
33MP0005666_abnormal_adipose_tissue1.78896959
34MP0008775_abnormal_heart_ventricle1.78304500
35MP0003279_aneurysm1.78190334
36MP0004484_altered_response_of1.77688672
37MP0005423_abnormal_somatic_nervous1.74886005
38MP0001486_abnormal_startle_reflex1.74406820
39MP0000569_abnormal_digit_pigmentation1.73956689
40MP0004510_myositis1.73351541
41MP0003252_abnormal_bile_duct1.72839352
42MP0010329_abnormal_lipoprotein_level1.72366976
43MP0000778_abnormal_nervous_system1.69385403
44MP0002106_abnormal_muscle_physiology1.68109108
45MP0002735_abnormal_chemical_nociception1.63376392
46MP0004924_abnormal_behavior1.59089477
47MP0005386_behavior/neurological_phenoty1.59089477
48MP0001501_abnormal_sleep_pattern1.58006913
49MP0004885_abnormal_endolymph1.56758309
50MP0009745_abnormal_behavioral_response1.56464569
51MP0002272_abnormal_nervous_system1.46383177
52MP0003635_abnormal_synaptic_transmissio1.45018802
53MP0002102_abnormal_ear_morphology1.44571614
54MP0003183_abnormal_peptide_metabolism1.44374147
55MP0009046_muscle_twitch1.43935514
56MP0003137_abnormal_impulse_conducting1.43722163
57MP0009384_cardiac_valve_regurgitation1.42504640
58MP0005369_muscle_phenotype1.38403311
59MP0010234_abnormal_vibrissa_follicle1.38042093
60MP0002269_muscular_atrophy1.37007617
61MP0005551_abnormal_eye_electrophysiolog1.36965068
62MP0003828_pulmonary_edema1.36085795
63MP0002006_tumorigenesis1.34913270
64MP0006138_congestive_heart_failure1.33603598
65MP0004085_abnormal_heartbeat1.32776737
66MP0003690_abnormal_glial_cell1.31228677
67MP0002734_abnormal_mechanical_nocicepti1.31177166
68MP0001502_abnormal_circadian_rhythm1.30652587
69MP0002063_abnormal_learning/memory/cond1.30114897
70MP0003300_gastrointestinal_ulcer1.28474145
71MP0000759_abnormal_skeletal_muscle1.26132055
72MP0005253_abnormal_eye_physiology1.23349265
73MP0002067_abnormal_sensory_capabilities1.23348627
74MP0004147_increased_porphyrin_level1.21896293
75MP0004142_abnormal_muscle_tone1.21286207
76MP0002332_abnormal_exercise_endurance1.20981558
77MP0002971_abnormal_brown_adipose1.18376269
78MP0003890_abnormal_embryonic-extraembry1.17392350
79MP0005334_abnormal_fat_pad1.17345090
80MP0005375_adipose_tissue_phenotype1.17306269
81MP0006054_spinal_hemorrhage1.17191256
82MP0002127_abnormal_cardiovascular_syste1.16043491
83MP0000750_abnormal_muscle_regeneration1.16012068
84MP0008438_abnormal_cutaneous_collagen1.14703935
85MP0008995_early_reproductive_senescence1.14483046
86MP0002108_abnormal_muscle_morphology1.14188547
87MP0002572_abnormal_emotion/affect_behav1.14092499
88MP0000733_abnormal_muscle_development1.14084699
89MP0008877_abnormal_DNA_methylation1.12263476
90MP0001661_extended_life_span1.11289293
91MP0002064_seizures1.11193013
92MP0001529_abnormal_vocalization1.10508912
93MP0009697_abnormal_copulation1.09696649
94MP0004043_abnormal_pH_regulation1.09119740
95MP0008875_abnormal_xenobiotic_pharmacok1.09083843
96MP0005645_abnormal_hypothalamus_physiol1.07608372
97MP0003045_fibrosis1.06807859
98MP0003191_abnormal_cellular_cholesterol1.05051418
99MP0002118_abnormal_lipid_homeostasis1.04004276
100MP0005646_abnormal_pituitary_gland1.03735356
101MP0004859_abnormal_synaptic_plasticity1.02774259
102MP0001968_abnormal_touch/_nociception1.02103196
103MP0002128_abnormal_blood_circulation1.00478678
104MP0000266_abnormal_heart_morphology0.99543527
105MP0000609_abnormal_liver_physiology0.99458300
106MP0005248_abnormal_Harderian_gland0.98843210
107MP0003633_abnormal_nervous_system0.96399228
108MP0001986_abnormal_taste_sensitivity0.96220309
109MP0000955_abnormal_spinal_cord0.96064758
110MP0000747_muscle_weakness0.95934175
111MP0002557_abnormal_social/conspecific_i0.94833323
112MP0000767_abnormal_smooth_muscle0.94015927
113MP0002882_abnormal_neuron_morphology0.93029372
114MP0003195_calcinosis0.92266573
115MP0004145_abnormal_muscle_electrophysio0.91281923
116MP0002876_abnormal_thyroid_physiology0.91197147
117MP0002138_abnormal_hepatobiliary_system0.90638535
118MP0005647_abnormal_sex_gland0.90483832
119MP0002184_abnormal_innervation0.89511822
120MP0002078_abnormal_glucose_homeostasis0.88744330
121MP0009115_abnormal_fat_cell0.88523411
122MP0006072_abnormal_retinal_apoptosis0.86604801
123MP0004233_abnormal_muscle_weight0.85407364
124MP0001970_abnormal_pain_threshold0.85333152
125MP0001440_abnormal_grooming_behavior0.85240094
126MP0001835_abnormal_antigen_presentation0.85022040
127MP0002751_abnormal_autonomic_nervous0.84810807
128MP0000003_abnormal_adipose_tissue0.83742579
129MP0003705_abnormal_hypodermis_morpholog0.83113026
130MP0003221_abnormal_cardiomyocyte_apopto0.82437792
131MP0005167_abnormal_blood-brain_barrier0.79740266
132MP0002752_abnormal_somatic_nervous0.79392663
133MP0002168_other_aberrant_phenotype0.79367351
134MP0000372_irregular_coat_pigmentation0.79035891
135MP0000631_abnormal_neuroendocrine_gland0.78421072
136MP0003567_abnormal_fetal_cardiomyocyte0.77912786
137MP0004185_abnormal_adipocyte_glucose0.77665919
138MP0000383_abnormal_hair_follicle0.77395758
139MP0000647_abnormal_sebaceous_gland0.76834200
140MP0008569_lethality_at_weaning0.76562565
141MP0002229_neurodegeneration0.76290588
142MP0005171_absent_coat_pigmentation0.75841771
143MP0003631_nervous_system_phenotype0.75301282
144MP0002928_abnormal_bile_duct0.74732130
145MP0005332_abnormal_amino_acid0.73491608
146MP0004808_abnormal_hematopoietic_stem0.73312720
147MP0005319_abnormal_enzyme/_coenzyme0.73295084
148MP0000371_diluted_coat_color0.70592349
149MP0005408_hypopigmentation0.68475658
150MP0000230_abnormal_systemic_arterial0.68322908
151MP0003787_abnormal_imprinting0.67431466
152MP0009764_decreased_sensitivity_to0.67151246
153MP0006036_abnormal_mitochondrial_physio0.66990906
154MP0000013_abnormal_adipose_tissue0.66664459
155MP0001853_heart_inflammation0.66188468
156MP0002877_abnormal_melanocyte_morpholog0.64301590
157MP0003950_abnormal_plasma_membrane0.63700161
158MP0001790_abnormal_immune_system0.62860725

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)4.42662624
2Hyperventilation (HP:0002883)4.30723469
3Exercise-induced muscle cramps (HP:0003710)4.25963628
4Calf muscle hypertrophy (HP:0008981)4.25133101
5Sudden death (HP:0001699)3.93215230
6Muscle hypertrophy of the lower extremities (HP:0008968)3.82745586
7Febrile seizures (HP:0002373)3.74325053
8Myoglobinuria (HP:0002913)3.62689502
9Hyporeflexia of lower limbs (HP:0002600)3.43562493
10Atrial fibrillation (HP:0005110)3.35388998
11Abnormality of the calf musculature (HP:0001430)3.24032321
12Drooling (HP:0002307)3.05547680
13Ketoacidosis (HP:0001993)3.04210812
14Abnormality of the left ventricular outflow tract (HP:0011103)3.00849220
15Subaortic stenosis (HP:0001682)3.00849220
16Hypoalphalipoproteinemia (HP:0003233)2.97986965
17Lipoatrophy (HP:0100578)2.96632839
18Primary atrial arrhythmia (HP:0001692)2.95618163
19Hematochezia (HP:0002573)2.92074741
20Hypoglycemic coma (HP:0001325)2.91410821
21Rimmed vacuoles (HP:0003805)2.90994163
22Ventricular tachycardia (HP:0004756)2.87485340
23Excessive salivation (HP:0003781)2.87211738
24Progressive cerebellar ataxia (HP:0002073)2.87016707
25Broad-based gait (HP:0002136)2.85560194
26Distal arthrogryposis (HP:0005684)2.80134897
27Absent speech (HP:0001344)2.73297834
28Supraventricular tachycardia (HP:0004755)2.69863513
29Muscle fiber splitting (HP:0003555)2.66787928
30Supraventricular arrhythmia (HP:0005115)2.64291934
31Genetic anticipation (HP:0003743)2.61889062
32Blue irides (HP:0000635)2.60684599
33EMG: neuropathic changes (HP:0003445)2.59826369
34Macroorchidism (HP:0000053)2.58818883
35Meningioma (HP:0002858)2.58432658
36Gaze-evoked nystagmus (HP:0000640)2.57310088
37Asymmetric septal hypertrophy (HP:0001670)2.57225241
38Ketosis (HP:0001946)2.54588851
39Mitral stenosis (HP:0001718)2.53526906
40Facial diplegia (HP:0001349)2.53363437
41Hyperglycemia (HP:0003074)2.51236236
42Lymphangioma (HP:0100764)2.50779295
43Fair hair (HP:0002286)2.49523053
44Focal seizures (HP:0007359)2.49428340
45EMG: myopathic abnormalities (HP:0003458)2.48691130
46Right ventricular cardiomyopathy (HP:0011663)2.48659893
47Difficulty running (HP:0009046)2.46863786
48Chronic hepatic failure (HP:0100626)2.46021011
49Verrucae (HP:0200043)2.45883581
50Papilloma (HP:0012740)2.45883581
51Focal motor seizures (HP:0011153)2.45703565
52Agammaglobulinemia (HP:0004432)2.43890726
53Hyperkalemia (HP:0002153)2.43841760
54Subacute progressive viral hepatitis (HP:0006572)2.42709069
55Hamartoma of the eye (HP:0010568)2.40727348
56Atrioventricular block (HP:0001678)2.40109410
57Atonic seizures (HP:0010819)2.36663378
58Dilated cardiomyopathy (HP:0001644)2.34311513
59Steppage gait (HP:0003376)2.33801926
60Abnormality of the fingertips (HP:0001211)2.33611319
61Exotropia (HP:0000577)2.33130312
62Conjunctival hamartoma (HP:0100780)2.32827523
63Syncope (HP:0001279)2.31693370
64Stomach cancer (HP:0012126)2.30763865
65Increased connective tissue (HP:0009025)2.29675325
66Muscle fiber inclusion bodies (HP:0100299)2.28513998
67Abnormality of fatty-acid metabolism (HP:0004359)2.27973388
68Abnormality of the renal cortex (HP:0011035)2.26687723
69Rhabdomyolysis (HP:0003201)2.25572664
70Protruding tongue (HP:0010808)2.25302631
71Hepatoblastoma (HP:0002884)2.24853245
72Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.24817924
73Thyroiditis (HP:0100646)2.24646052
74Prolonged QT interval (HP:0001657)2.21140589
75Heart block (HP:0012722)2.18891219
76Action tremor (HP:0002345)2.17765022
77Hyperlipoproteinemia (HP:0010980)2.16821804
78Pancreatic cysts (HP:0001737)2.16390386
79Pancreatic islet-cell hyperplasia (HP:0004510)2.16261001
80Deep venous thrombosis (HP:0002625)2.15920169
81Papillary thyroid carcinoma (HP:0002895)2.15697928
82Type 1 muscle fiber predominance (HP:0003803)2.14802923
83Cortical dysplasia (HP:0002539)2.14392702
84Myotonia (HP:0002486)2.14391255
85Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.13152009
86Broad metatarsal (HP:0001783)2.10250796
87Pheochromocytoma (HP:0002666)2.09877563
88Widely spaced teeth (HP:0000687)2.09432828
89Areflexia of lower limbs (HP:0002522)2.09099970
90Complement deficiency (HP:0004431)2.08871130
91Left ventricular hypertrophy (HP:0001712)2.08032309
92Dysmetric saccades (HP:0000641)2.07012952
93Generalized hypopigmentation of hair (HP:0011358)2.05885877
94Dialeptic seizures (HP:0011146)2.05781088
95Enlarged penis (HP:0000040)2.05757231
96Neoplasm of the adrenal gland (HP:0100631)2.05505695
97Amyotrophic lateral sclerosis (HP:0007354)2.03204463
98Abnormality of the pubic bones (HP:0003172)2.02322223
99Bundle branch block (HP:0011710)2.00261705
100Medial flaring of the eyebrow (HP:0010747)1.99573827
101Hypoglycemic seizures (HP:0002173)1.99316195
102Thyroid carcinoma (HP:0002890)1.97238817
103Epidermoid cyst (HP:0200040)1.96993539
104Hyperglycinuria (HP:0003108)1.95400794
105Toxemia of pregnancy (HP:0100603)1.95387620
106Cubitus valgus (HP:0002967)1.93236501
107Abnormality of the renal medulla (HP:0100957)1.92746718
108Insulin-resistant diabetes mellitus (HP:0000831)1.92540435
109Neoplasm of the tracheobronchial system (HP:0100552)1.92521750
110Hyperammonemia (HP:0001987)1.91094288
111Hypoplastic ischia (HP:0003175)1.91049464
112Inability to walk (HP:0002540)1.90706442
113Abnormality of the ischium (HP:0003174)1.89759773
114Abnormal atrioventricular conduction (HP:0005150)1.89602403
115Asymmetry of the thorax (HP:0001555)1.89106943
116Hypoplasia of the thymus (HP:0000778)1.88709466
117Gait imbalance (HP:0002141)1.88389669
118Hypolipoproteinemia (HP:0010981)1.87112289
119Hepatocellular carcinoma (HP:0001402)1.87013742
120Tetraparesis (HP:0002273)1.86657287
121Epileptic encephalopathy (HP:0200134)1.86156177
122Nemaline bodies (HP:0003798)1.85914288
123Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.85035600
124Renal cortical cysts (HP:0000803)1.84586743
125Pachygyria (HP:0001302)1.84001093
126Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.82984315
127Nephronophthisis (HP:0000090)1.81994277
128Palpitations (HP:0001962)1.80962196
129Gastrointestinal stroma tumor (HP:0100723)1.80451407
130Neuroendocrine neoplasm (HP:0100634)1.77230834
131Visceral angiomatosis (HP:0100761)1.76819827
132Neoplasm of the heart (HP:0100544)1.76362913
133Long clavicles (HP:0000890)1.76260485
134Oligomenorrhea (HP:0000876)1.76134865
135Vertebral arch anomaly (HP:0008438)1.75499755
136Intrahepatic cholestasis (HP:0001406)1.75000813
137Xanthomatosis (HP:0000991)1.74258791
138Abnormal EKG (HP:0003115)1.74089721
139Aqueductal stenosis (HP:0002410)1.73103894
140Pancreatic fibrosis (HP:0100732)1.73039083
141Aortic aneurysm (HP:0004942)1.72824959
142Frequent falls (HP:0002359)1.72684664
143Ventricular arrhythmia (HP:0004308)1.72647398
144Hypoplastic labia majora (HP:0000059)1.72237073
145Abnormality of potassium homeostasis (HP:0011042)1.72029873
146Truncal obesity (HP:0001956)1.71890269
147Thyroid-stimulating hormone excess (HP:0002925)1.71037278
148Volvulus (HP:0002580)1.70381268
149Postural instability (HP:0002172)1.70281479
150Hemangiomatosis (HP:0007461)1.70085938
151Ulnar claw (HP:0001178)1.68985097
152True hermaphroditism (HP:0010459)1.68519753
153Megalencephaly (HP:0001355)1.67826652
154Cupped ear (HP:0000378)1.67800844
155Abnormality of the labia majora (HP:0012881)1.66449299
156Limb hypertonia (HP:0002509)1.66114779
157Bone cyst (HP:0012062)1.65667688
158Genital tract atresia (HP:0001827)1.65372511
159Cellulitis (HP:0100658)1.65147703
160Alveolar cell carcinoma (HP:0006519)1.63859840
161Tubulointerstitial nephritis (HP:0001970)1.63731225

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.49662089
2FRK3.42362211
3MARK13.41983568
4INSRR3.20924857
5OBSCN3.06837761
6FGFR22.81553116
7TTN2.72518217
8MAP3K102.45297272
9MAP3K42.31970306
10FGFR32.31385725
11PKN22.22823592
12CAMK1D2.03490105
13SIK11.99916928
14SGK21.97825100
15SGK31.94391592
16STK241.93571819
17TRIB31.92057690
18PIK3CA1.75735824
19ZAK1.65483519
20PHKG11.64580541
21PHKG21.64580541
22MAP4K21.59963879
23TNIK1.58268280
24CAMK1G1.57988906
25ERBB31.55145956
26LMTK21.53741654
27BCR1.48012634
28LATS11.46982637
29TGFBR21.45195619
30FGFR41.40650147
31MAP3K71.39761184
32WNK31.38780922
33MAP2K71.37871127
34PDK41.34608421
35PDK31.34608421
36NTRK31.30145473
37MAPK71.29243368
38ACVR1B1.24038898
39JAK11.23827439
40SGK4941.22448612
41SGK2231.22448612
42TIE11.22166400
43MYLK1.20087302
44MAP2K41.19340680
45BMPR1B1.14597964
46NLK1.11794014
47STK41.10890565
48CDK61.10032647
49PRKAA11.08545359
50PRKAA21.07940211
51MAPK121.07404762
52CSF1R1.06853729
53NEK91.04202467
54NTRK21.04115129
55PTK61.02967494
56ADRBK21.02790713
57SIK21.01789542
58FLT30.99259401
59DMPK0.97467506
60PDGFRA0.97349625
61PDK20.96273326
62CAMKK20.91921538
63CAMK40.91482631
64TRPM70.90864300
65GRK10.90693829
66MAP3K140.89837708
67NUAK10.87648182
68DYRK1A0.83113817
69STK110.81284869
70DAPK20.81245367
71STK30.81212236
72TRIM280.80916178
73EPHA40.79492066
74BCKDK0.77787614
75EPHA30.77600901
76WNK10.76372807
77PAK30.75056071
78EEF2K0.74202893
79PDGFRB0.73709243
80BRD40.73560939
81MAP3K60.73355321
82PIK3CG0.72029908
83PRKCH0.72027556
84PRKD10.71723488
85TYK20.71717673
86PKN10.71426035
87CAMK10.71005230
88DYRK1B0.70960124
89PINK10.70931825
90OXSR10.70771002
91ITK0.70579725
92STK390.69297399
93CHUK0.67261494
94FER0.65208884
95STK38L0.64290835
96RET0.64284579
97NEK60.63202134
98YES10.61937982
99CAMK2A0.61064792
100CDK90.60789144
101CSNK1G20.60352578
102MAP3K20.59560563
103SGK10.58206261
104PNCK0.57800530
105RPS6KB10.56384071
106PLK20.56198370
107PRKG10.54717491
108ERBB20.54544068
109DYRK30.52815125
110MAP2K30.51896627
111SYK0.50412812
112AKT30.49784419
113MARK20.49781777
114JAK20.49650682
115MAPK110.49093049
116PRKCQ0.49075852
117CDK50.48835352
118RIPK10.48738127
119ADRBK10.48127954
120PDK10.47680829
121CDK120.47573916
122PRKCZ0.47352411
123ROCK10.47117166
124MAPK130.47088692
125TAOK30.46912623
126GRK70.46439600
127BTK0.44811270
128MUSK0.44587006
129HIPK20.44035165
130CSNK1G10.43693217
131PRKCG0.41966186
132MAP4K10.41755104
133PRKCE0.41098981
134MARK30.41097993
135IGF1R0.40970453
136PRKACA0.40865653
137CAMK2B0.40398286
138CSNK1D0.38942610
139MINK10.38778858
140DYRK20.38458536
141KSR10.38119667
142HCK0.37509478
143IRAK10.36913083
144TEC0.36899122
145CAMK2D0.36724859
146UHMK10.36296985
147RPS6KL10.35660679
148RPS6KC10.35660679
149RPS6KA20.34646830
150MAP3K130.33951947
151FGFR10.33638150

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid degradation_Homo sapiens_hsa000712.96574829
2Propanoate metabolism_Homo sapiens_hsa006402.85440351
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.53324720
4Fatty acid metabolism_Homo sapiens_hsa012122.35711347
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.32861591
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.31529542
7Nicotine addiction_Homo sapiens_hsa050332.16483344
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.09113017
9Nitrogen metabolism_Homo sapiens_hsa009101.94972249
10Primary bile acid biosynthesis_Homo sapiens_hsa001201.86483360
11Lysine degradation_Homo sapiens_hsa003101.85628351
12Insulin resistance_Homo sapiens_hsa049311.83320103
13PPAR signaling pathway_Homo sapiens_hsa033201.80853778
14Circadian entrainment_Homo sapiens_hsa047131.76599530
15Dilated cardiomyopathy_Homo sapiens_hsa054141.65723780
16Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.61285602
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.58706114
18Tryptophan metabolism_Homo sapiens_hsa003801.58331464
19Butanoate metabolism_Homo sapiens_hsa006501.58168765
20Glutamatergic synapse_Homo sapiens_hsa047241.49399481
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.46026522
22Phototransduction_Homo sapiens_hsa047441.45576883
23Morphine addiction_Homo sapiens_hsa050321.42789310
24Arginine biosynthesis_Homo sapiens_hsa002201.39391362
25GABAergic synapse_Homo sapiens_hsa047271.39133644
26Insulin secretion_Homo sapiens_hsa049111.38975826
27B cell receptor signaling pathway_Homo sapiens_hsa046621.37518529
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.33350422
29Adipocytokine signaling pathway_Homo sapiens_hsa049201.32765696
30Calcium signaling pathway_Homo sapiens_hsa040201.32042377
31Complement and coagulation cascades_Homo sapiens_hsa046101.31970719
32Peroxisome_Homo sapiens_hsa041461.31508072
33Dopaminergic synapse_Homo sapiens_hsa047281.31451454
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.30495009
35Amphetamine addiction_Homo sapiens_hsa050311.29524230
36Regulation of autophagy_Homo sapiens_hsa041401.28188414
37Long-term depression_Homo sapiens_hsa047301.27467257
38Starch and sucrose metabolism_Homo sapiens_hsa005001.26068035
39Taste transduction_Homo sapiens_hsa047421.26005769
40Type II diabetes mellitus_Homo sapiens_hsa049301.25773788
41Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.25122718
42Cholinergic synapse_Homo sapiens_hsa047251.25063586
43Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.23391089
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21319832
45Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.19820331
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17974975
47AMPK signaling pathway_Homo sapiens_hsa041521.17542147
48Cocaine addiction_Homo sapiens_hsa050301.17373858
49Fatty acid biosynthesis_Homo sapiens_hsa000611.13324535
50Insulin signaling pathway_Homo sapiens_hsa049101.11276090
51beta-Alanine metabolism_Homo sapiens_hsa004101.09323679
52Axon guidance_Homo sapiens_hsa043601.07583316
53FoxO signaling pathway_Homo sapiens_hsa040681.05473948
54Glucagon signaling pathway_Homo sapiens_hsa049221.05119840
55Serotonergic synapse_Homo sapiens_hsa047261.04705970
56Linoleic acid metabolism_Homo sapiens_hsa005911.04392390
57Salivary secretion_Homo sapiens_hsa049701.04252938
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03066989
59Pyruvate metabolism_Homo sapiens_hsa006201.00419354
60Carbon metabolism_Homo sapiens_hsa012000.99777084
61Vascular smooth muscle contraction_Homo sapiens_hsa042700.99682565
62ABC transporters_Homo sapiens_hsa020100.99169848
63mTOR signaling pathway_Homo sapiens_hsa041500.99070558
64Caffeine metabolism_Homo sapiens_hsa002320.95654083
65Staphylococcus aureus infection_Homo sapiens_hsa051500.95311373
66Cardiac muscle contraction_Homo sapiens_hsa042600.92624901
67Endometrial cancer_Homo sapiens_hsa052130.91859146
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.90669676
69Long-term potentiation_Homo sapiens_hsa047200.89651458
70Gastric acid secretion_Homo sapiens_hsa049710.85909598
71Ether lipid metabolism_Homo sapiens_hsa005650.84666593
72Olfactory transduction_Homo sapiens_hsa047400.84592360
73ErbB signaling pathway_Homo sapiens_hsa040120.84033821
74Aldosterone synthesis and secretion_Homo sapiens_hsa049250.82724490
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81466377
76Non-small cell lung cancer_Homo sapiens_hsa052230.80508647
77Viral myocarditis_Homo sapiens_hsa054160.80256619
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80173446
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78501589
80Focal adhesion_Homo sapiens_hsa045100.78430507
81Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78232633
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78087591
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78006759
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77056182
85Choline metabolism in cancer_Homo sapiens_hsa052310.77004821
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76727587
87Circadian rhythm_Homo sapiens_hsa047100.75642255
88Systemic lupus erythematosus_Homo sapiens_hsa053220.75436426
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74344026
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74017843
91Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72455466
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71875761
93Chronic myeloid leukemia_Homo sapiens_hsa052200.70353991
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.70103683
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.69572078
96Bile secretion_Homo sapiens_hsa049760.69265165
97Ovarian steroidogenesis_Homo sapiens_hsa049130.68769958
98Adherens junction_Homo sapiens_hsa045200.68274736
99Fatty acid elongation_Homo sapiens_hsa000620.67432686
100Small cell lung cancer_Homo sapiens_hsa052220.67345094
101Ras signaling pathway_Homo sapiens_hsa040140.66622906
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.66379206
103Inositol phosphate metabolism_Homo sapiens_hsa005620.64423561
104GnRH signaling pathway_Homo sapiens_hsa049120.63963731
105Pancreatic secretion_Homo sapiens_hsa049720.63339904
106Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.61379499
107MAPK signaling pathway_Homo sapiens_hsa040100.61249690
108Gap junction_Homo sapiens_hsa045400.60088744
109Glycerolipid metabolism_Homo sapiens_hsa005610.59541599
110Osteoclast differentiation_Homo sapiens_hsa043800.59484550
111Tight junction_Homo sapiens_hsa045300.58890769
112Platelet activation_Homo sapiens_hsa046110.58123329
113Dorso-ventral axis formation_Homo sapiens_hsa043200.57884756
114Toxoplasmosis_Homo sapiens_hsa051450.57692167
115T cell receptor signaling pathway_Homo sapiens_hsa046600.56802532
116AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56560511
117Proteoglycans in cancer_Homo sapiens_hsa052050.56483958
118Pancreatic cancer_Homo sapiens_hsa052120.56100937
119Leukocyte transendothelial migration_Homo sapiens_hsa046700.56089669
120Acute myeloid leukemia_Homo sapiens_hsa052210.54423751
121Jak-STAT signaling pathway_Homo sapiens_hsa046300.53642559
122Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53418721
123Selenocompound metabolism_Homo sapiens_hsa004500.53326445
124Phenylalanine metabolism_Homo sapiens_hsa003600.52117105
125Primary immunodeficiency_Homo sapiens_hsa053400.50834812
126Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50137189
127Rap1 signaling pathway_Homo sapiens_hsa040150.47938222
128Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47742908
129Estrogen signaling pathway_Homo sapiens_hsa049150.47647766
130Histidine metabolism_Homo sapiens_hsa003400.46220341
131Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45931727
132Prostate cancer_Homo sapiens_hsa052150.45883211
133Prolactin signaling pathway_Homo sapiens_hsa049170.45536138
134Glioma_Homo sapiens_hsa052140.44784185
135NF-kappa B signaling pathway_Homo sapiens_hsa040640.44722331
136Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43656133
137Steroid hormone biosynthesis_Homo sapiens_hsa001400.43349160
138Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42171856
139Tyrosine metabolism_Homo sapiens_hsa003500.40883315
140Neurotrophin signaling pathway_Homo sapiens_hsa047220.39506831
141HIF-1 signaling pathway_Homo sapiens_hsa040660.39036606
142Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38493977
143Renin secretion_Homo sapiens_hsa049240.38301200
144Retinol metabolism_Homo sapiens_hsa008300.37975130
145MicroRNAs in cancer_Homo sapiens_hsa052060.37582669
146Toll-like receptor signaling pathway_Homo sapiens_hsa046200.37001084
147Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33453315
148Oxytocin signaling pathway_Homo sapiens_hsa049210.33091294
149Colorectal cancer_Homo sapiens_hsa052100.32150040
150Chemical carcinogenesis_Homo sapiens_hsa052040.32095015
151Renal cell carcinoma_Homo sapiens_hsa052110.31582594
152cAMP signaling pathway_Homo sapiens_hsa040240.30831477
153Sulfur metabolism_Homo sapiens_hsa009200.30653204

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