KLHL15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the kelch-like family of proteins that share a common domain structure consisting of an N-terminal broad-complex, tramtrack, bric-a-brac/poxvirus and zinc finger domain and C-terminal kelch repeat motifs. The encoded protein may be involved in protein ubiquitination and cytoskeletal organization. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)8.49850794
2nuclear pore organization (GO:0006999)7.92835647
3pore complex assembly (GO:0046931)6.35775943
4mitotic sister chromatid cohesion (GO:0007064)6.03846238
5mitotic chromosome condensation (GO:0007076)5.36727976
6sister chromatid segregation (GO:0000819)5.04406504
7mitotic sister chromatid segregation (GO:0000070)5.02609099
8DNA unwinding involved in DNA replication (GO:0006268)4.98197025
9dosage compensation (GO:0007549)4.80439380
10presynaptic membrane assembly (GO:0097105)4.69976520
11negative regulation of cell cycle G2/M phase transition (GO:1902750)4.61218921
12DNA replication checkpoint (GO:0000076)4.53556853
13DNA methylation involved in gamete generation (GO:0043046)4.48685558
14piRNA metabolic process (GO:0034587)4.47339220
15negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.41660350
16mitotic nuclear envelope disassembly (GO:0007077)4.29359431
17DNA replication initiation (GO:0006270)4.26462747
18protein localization to chromosome, centromeric region (GO:0071459)4.22545776
19negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.20061726
20regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.18087985
21membrane disassembly (GO:0030397)4.13572814
22nuclear envelope disassembly (GO:0051081)4.13572814
23negative regulation of histone methylation (GO:0031061)4.09561808
24neuron cell-cell adhesion (GO:0007158)4.08161944
25presynaptic membrane organization (GO:0097090)4.07307732
26positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.05252157
27positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.05252157
28positive regulation of mitotic sister chromatid separation (GO:1901970)4.05252157
29postsynaptic membrane organization (GO:0001941)4.04372903
30regulation of RNA export from nucleus (GO:0046831)4.01254914
31DNA duplex unwinding (GO:0032508)3.92078021
32positive regulation of chromosome segregation (GO:0051984)3.88915966
33negative regulation of synaptic transmission, GABAergic (GO:0032229)3.83461877
34DNA geometric change (GO:0032392)3.80471858
35protein localization to kinetochore (GO:0034501)3.72481416
36monoubiquitinated protein deubiquitination (GO:0035520)3.71787509
37microtubule depolymerization (GO:0007019)3.69952680
38regulation of DNA damage checkpoint (GO:2000001)3.57825240
39lymph vessel development (GO:0001945)3.57734101
40cellular protein complex localization (GO:0034629)3.55306271
41DNA strand elongation involved in DNA replication (GO:0006271)3.53368140
42meiotic chromosome segregation (GO:0045132)3.50761905
43regulation of sister chromatid cohesion (GO:0007063)3.49400858
44double-strand break repair via nonhomologous end joining (GO:0006303)3.48591179
45non-recombinational repair (GO:0000726)3.48591179
46nuclear envelope organization (GO:0006998)3.47401397
47pre-miRNA processing (GO:0031054)3.46794199
48regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.46117005
49negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.44512390
50DNA strand elongation (GO:0022616)3.42616474
51DNA conformation change (GO:0071103)3.41306014
52regulation of retinoic acid receptor signaling pathway (GO:0048385)3.40250366
53startle response (GO:0001964)3.39866866
54regulation of mammary gland epithelial cell proliferation (GO:0033599)3.33007472
55regulation of chromatin binding (GO:0035561)3.30839897
56regulation of DNA-dependent DNA replication (GO:0090329)3.30541574
57maturation of 5.8S rRNA (GO:0000460)3.28553695
58regulation of meiosis I (GO:0060631)3.27955924
59chromosome condensation (GO:0030261)3.27937656
60negative regulation of chromosome segregation (GO:0051985)3.27240003
61neurotransmitter-gated ion channel clustering (GO:0072578)3.24494107
62positive regulation of mitochondrial fission (GO:0090141)3.24366410
63regulation of NFAT protein import into nucleus (GO:0051532)3.21425534
64regulation of histone H3-K4 methylation (GO:0051569)3.20927918
65protein K11-linked deubiquitination (GO:0035871)3.18965040
66DNA packaging (GO:0006323)3.17833886
67attachment of spindle microtubules to kinetochore (GO:0008608)3.16462175
68regulation of sister chromatid segregation (GO:0033045)3.15872826
69regulation of mitotic sister chromatid separation (GO:0010965)3.15872826
70regulation of mitotic sister chromatid segregation (GO:0033047)3.15872826
71peripheral nervous system neuron development (GO:0048935)3.15827937
72regulation of centriole replication (GO:0046599)3.14671281
73protein-cofactor linkage (GO:0018065)3.14548572
74negative regulation of mast cell activation (GO:0033004)3.13362400
75negative regulation of mRNA processing (GO:0050686)3.12284857
76positive regulation of meiosis (GO:0045836)3.12159684
77protein localization to chromosome (GO:0034502)3.11998323
78regulation of nucleobase-containing compound transport (GO:0032239)3.11710022
79regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.11341289
80dopamine transport (GO:0015872)3.11103822
81regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.10272584
82regulation of mitotic metaphase/anaphase transition (GO:0030071)3.10272584
83regulation of histone H3-K9 methylation (GO:0051570)3.10094246
84regulation of chromosome segregation (GO:0051983)3.09985553
85positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.03753292
86negative regulation of dendrite morphogenesis (GO:0050774)3.02968173
87DNA double-strand break processing (GO:0000729)3.01636820
88translesion synthesis (GO:0019985)3.01493355
89cytochrome complex assembly (GO:0017004)2.99432263
90mRNA transport (GO:0051028)2.96624970
91inositol phosphate catabolic process (GO:0071545)2.96167119
92male meiosis (GO:0007140)2.96069273
93DNA synthesis involved in DNA repair (GO:0000731)2.96046942
94telomere maintenance via semi-conservative replication (GO:0032201)2.95678883
95positive regulation of DNA-templated transcription, initiation (GO:2000144)2.94268747
96negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.93519922
97negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.93519922
98negative regulation of mitotic sister chromatid segregation (GO:0033048)2.93519922
99negative regulation of mitotic sister chromatid separation (GO:2000816)2.93519922
100negative regulation of sister chromatid segregation (GO:0033046)2.93519922
101facial nerve structural organization (GO:0021612)2.93476485
102spliceosomal tri-snRNP complex assembly (GO:0000244)2.92057360
103male meiosis I (GO:0007141)2.91129241
104protein complex localization (GO:0031503)2.91128985
105embryonic process involved in female pregnancy (GO:0060136)2.90525229
106cytoplasmic mRNA processing body assembly (GO:0033962)2.90506934
107proximal/distal pattern formation (GO:0009954)2.89847648
108spindle checkpoint (GO:0031577)2.89289320
109DNA topological change (GO:0006265)2.87484403
110protein neddylation (GO:0045116)2.86067001
111negative regulation of neurotransmitter transport (GO:0051589)2.85211196
112positive regulation of meiotic cell cycle (GO:0051446)2.84482276
113DNA ligation (GO:0006266)2.83995239
114proteasome assembly (GO:0043248)2.83737697
115chromatin assembly (GO:0031497)2.82178896
116mitotic spindle assembly checkpoint (GO:0007094)2.81159052
117mRNA stabilization (GO:0048255)2.78529512
118RNA stabilization (GO:0043489)2.78529512
119spindle assembly checkpoint (GO:0071173)2.78176802
120mitotic G2/M transition checkpoint (GO:0044818)2.78167083
121regulation of transforming growth factor beta2 production (GO:0032909)2.77347988
122mitotic spindle checkpoint (GO:0071174)2.77343126
123regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.76963487
124regulation of mitotic spindle checkpoint (GO:1903504)2.76963487
125detection of light stimulus involved in sensory perception (GO:0050962)2.75665805
126detection of light stimulus involved in visual perception (GO:0050908)2.75665805
127regulation of centrosome cycle (GO:0046605)2.75018909
128respiratory chain complex IV assembly (GO:0008535)2.74863516
129chromosome segregation (GO:0007059)2.73810631
130peptidyl-lysine trimethylation (GO:0018023)2.73282544
131mitochondrial DNA metabolic process (GO:0032042)2.72532619
132mRNA export from nucleus (GO:0006406)2.72465251
133mannosylation (GO:0097502)2.72264195
134reciprocal DNA recombination (GO:0035825)2.70466565
135reciprocal meiotic recombination (GO:0007131)2.70466565
136sister chromatid cohesion (GO:0007062)2.69902223
137protein K6-linked ubiquitination (GO:0085020)2.67988425
138serotonin receptor signaling pathway (GO:0007210)2.67569672
139poly(A)+ mRNA export from nucleus (GO:0016973)2.67330189
140regulation of rhodopsin mediated signaling pathway (GO:0022400)2.65736875
141regulation of nuclear cell cycle DNA replication (GO:0033262)2.65590152
142negative regulation of DNA-dependent DNA replication (GO:2000104)2.65103132
143nonmotile primary cilium assembly (GO:0035058)2.62528429
144neuron-neuron synaptic transmission (GO:0007270)2.62462037
145GMP metabolic process (GO:0046037)2.61983608
146protein K48-linked deubiquitination (GO:0071108)2.59880488
147negative regulation of keratinocyte proliferation (GO:0010839)2.57881256
148positive regulation of protein homodimerization activity (GO:0090073)2.56058180
149synaptic transmission, glutamatergic (GO:0035249)2.55550420
150kinetochore assembly (GO:0051382)2.54961748
151cellular response to gamma radiation (GO:0071480)2.53651407
152kinetochore organization (GO:0051383)2.53243124
153microtubule polymerization or depolymerization (GO:0031109)2.52302338
154negative regulation of execution phase of apoptosis (GO:1900118)2.51936932
155oocyte maturation (GO:0001556)2.51148889
156meiotic nuclear division (GO:0007126)2.49715672
157rhodopsin mediated signaling pathway (GO:0016056)2.49676153
158cranial nerve structural organization (GO:0021604)2.47754450
159negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.47575679
160synaptonemal complex assembly (GO:0007130)2.46835492
161termination of RNA polymerase III transcription (GO:0006386)2.46478212
162transcription elongation from RNA polymerase III promoter (GO:0006385)2.46478212
163protein complex biogenesis (GO:0070271)2.46378594
164CENP-A containing nucleosome assembly (GO:0034080)2.46349473
165protein localization to synapse (GO:0035418)2.45959738
1667-methylguanosine mRNA capping (GO:0006370)2.45602451
167synaptonemal complex organization (GO:0070193)2.45095050
168regulation of mitochondrial fission (GO:0090140)2.44609760
169RNA capping (GO:0036260)2.44241497
1707-methylguanosine RNA capping (GO:0009452)2.44241497
171regulation of synaptic vesicle exocytosis (GO:2000300)2.44025566
172positive regulation of synapse assembly (GO:0051965)2.43319549
173histone H2A acetylation (GO:0043968)2.42228499
174chromatin remodeling at centromere (GO:0031055)2.41515329
175viral protein processing (GO:0019082)2.41444764
176negative regulation of meiosis (GO:0045835)2.41317178
177protein K11-linked ubiquitination (GO:0070979)2.40271014
178neurotransmitter uptake (GO:0001504)2.37499718
179positive regulation of neurotransmitter secretion (GO:0001956)2.36413228
180mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.35342587
181positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.35342587
182cullin deneddylation (GO:0010388)2.35087586
183vocalization behavior (GO:0071625)2.34968410
184regulation of DNA endoreduplication (GO:0032875)2.34793329
185regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.33694554
186regulation of glutamate secretion (GO:0014048)2.32690609
187synaptic vesicle docking involved in exocytosis (GO:0016081)2.32675279
188G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.32096312
189mechanosensory behavior (GO:0007638)2.31486330
190regulation of male gonad development (GO:2000018)2.31046810
191dendrite development (GO:0016358)2.31014820
192DNA catabolic process, exonucleolytic (GO:0000738)2.30832293
193transferrin transport (GO:0033572)2.30790479
194negative regulation of neurotransmitter secretion (GO:0046929)2.30120780

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.35404968
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.62270530
3GBX2_23144817_ChIP-Seq_PC3_Human4.16014818
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.79943490
5NOTCH1_21737748_ChIP-Seq_TLL_Human3.43076348
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.41271016
7KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.39223150
8TAF15_26573619_Chip-Seq_HEK293_Human3.09712964
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.86096729
10E2F1_21310950_ChIP-Seq_MCF-7_Human2.79154437
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.77993364
12EZH2_22144423_ChIP-Seq_EOC_Human2.75981483
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.74966367
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.62978217
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.62697350
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.57392018
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.53547067
18PCGF2_27294783_Chip-Seq_ESCs_Mouse2.51219106
19IGF1R_20145208_ChIP-Seq_DFB_Human2.49253926
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.44383422
21SMAD_19615063_ChIP-ChIP_OVARY_Human2.34783834
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.26280836
23AR_21909140_ChIP-Seq_LNCAP_Human2.25871965
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.18847550
25FUS_26573619_Chip-Seq_HEK293_Human2.16511128
26RNF2_27304074_Chip-Seq_NSC_Mouse2.15078987
27RBPJ_22232070_ChIP-Seq_NCS_Mouse2.14062181
28PKCTHETA_26484144_Chip-Seq_BREAST_Human2.10663833
29P300_19829295_ChIP-Seq_ESCs_Human2.08300090
30* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.04893724
31TTF2_22483619_ChIP-Seq_HELA_Human1.97530112
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.96504950
33XRN2_22483619_ChIP-Seq_HELA_Human1.96001733
34* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.95523084
35EWS_26573619_Chip-Seq_HEK293_Human1.93460652
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.89458100
37CIITA_25753668_ChIP-Seq_RAJI_Human1.85915899
38HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.83524635
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.82407700
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81573296
41MYC_22102868_ChIP-Seq_BL_Human1.81446034
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.78797906
43* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.77907845
44NANOG_18555785_Chip-Seq_ESCs_Mouse1.75751836
45KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.75689237
46SMAD4_21799915_ChIP-Seq_A2780_Human1.75188336
47KDM5A_27292631_Chip-Seq_BREAST_Human1.71490556
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.69364671
49TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.69197821
50E2F1_18555785_Chip-Seq_ESCs_Mouse1.68898546
51CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.68091621
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66159724
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.65984913
54MYC_19030024_ChIP-ChIP_MESCs_Mouse1.64511768
55NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.64448948
56* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.64395975
57* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.63385530
58EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.63031484
59P53_22387025_ChIP-Seq_ESCs_Mouse1.63010523
60STAT3_18555785_Chip-Seq_ESCs_Mouse1.61461914
61SUZ12_18555785_Chip-Seq_ESCs_Mouse1.60466492
62HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.59330123
63CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55801211
64CBX2_27304074_Chip-Seq_ESCs_Mouse1.55160350
65IRF1_19129219_ChIP-ChIP_H3396_Human1.53351568
66ER_23166858_ChIP-Seq_MCF-7_Human1.52525906
67P300_18555785_Chip-Seq_ESCs_Mouse1.52385089
68TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.52095222
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51506304
70NELFA_20434984_ChIP-Seq_ESCs_Mouse1.50862605
71EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.50725355
72E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.49543001
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.48557229
74CMYC_18555785_Chip-Seq_ESCs_Mouse1.47306196
75MYC_19079543_ChIP-ChIP_MESCs_Mouse1.47204946
76MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47070786
77RUNX1_27457419_Chip-Seq_LIVER_Mouse1.44044501
78NMYC_18555785_Chip-Seq_ESCs_Mouse1.43590584
79TAL1_26923725_Chip-Seq_HPCs_Mouse1.43326107
80PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43211539
81POU5F1_16153702_ChIP-ChIP_HESCs_Human1.42380328
82AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41018876
83PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39907363
84OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39680289
85MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.39367253
86SOX2_18555785_Chip-Seq_ESCs_Mouse1.37689216
87CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.37651394
88THAP11_20581084_ChIP-Seq_MESCs_Mouse1.36943452
89HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.36442597
90MYCN_18555785_ChIP-Seq_MESCs_Mouse1.35828429
91DCP1A_22483619_ChIP-Seq_HELA_Human1.35291195
92CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.33484834
93RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.31439746
94OCT4_18555785_Chip-Seq_ESCs_Mouse1.31222613
95STAT3_23295773_ChIP-Seq_U87_Human1.30702814
96MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.30398721
97TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29307451
98NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.28919018
99ZFX_18555785_ChIP-Seq_MESCs_Mouse1.28473025
100PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28266966
101TCF4_23295773_ChIP-Seq_U87_Human1.26623159
102EST1_17652178_ChIP-ChIP_JURKAT_Human1.24634677
103AR_25329375_ChIP-Seq_VCAP_Human1.24306575
104* CHD1_26751641_Chip-Seq_LNCaP_Human1.23894051
105VDR_23849224_ChIP-Seq_CD4+_Human1.23374364
106KLF4_18555785_Chip-Seq_ESCs_Mouse1.23138042
107SMAD3_21741376_ChIP-Seq_EPCs_Human1.22859073
108SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.21823620
109UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20395303
110ZFX_18555785_Chip-Seq_ESCs_Mouse1.20305710
111* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.20248180
112CTCF_18555785_Chip-Seq_ESCs_Mouse1.19315058
113PIAS1_25552417_ChIP-Seq_VCAP_Human1.19108146
114* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.19060929
115JUN_21703547_ChIP-Seq_K562_Human1.17518979
116LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17402484
117PU1_27457419_Chip-Seq_LIVER_Mouse1.17368774
118NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.17268331
119TFEB_21752829_ChIP-Seq_HELA_Human1.16955395
120SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16755215
121YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16740918
122TP63_19390658_ChIP-ChIP_HaCaT_Human1.14856361
123SMAD1_18555785_Chip-Seq_ESCs_Mouse1.14516349
124ELK1_19687146_ChIP-ChIP_HELA_Human1.13616721
125JARID2_20064375_ChIP-Seq_MESCs_Mouse1.12842189
126ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12131780
127ESRRB_18555785_Chip-Seq_ESCs_Mouse1.11211491
128EZH2_27304074_Chip-Seq_ESCs_Mouse1.10358239
129PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10350379
130MYC_18940864_ChIP-ChIP_HL60_Human1.09816297
131ETS1_20019798_ChIP-Seq_JURKAT_Human1.09086343
132CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08353269
133SRF_21415370_ChIP-Seq_HL-1_Mouse1.07048765
134RUNX2_22187159_ChIP-Seq_PCA_Human1.06738610
135CRX_20693478_ChIP-Seq_RETINA_Mouse1.06399149
136POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06264077
137TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06264077
138FOXP3_21729870_ChIP-Seq_TREG_Human1.05926417
139FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05565552
140DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.05396202
141PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04226768
142SOX9_26525672_Chip-Seq_HEART_Mouse1.03427534
143AR_21572438_ChIP-Seq_LNCaP_Human1.03028811
144* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.01963393
145SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.01743688
146* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.01591972
147MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01154472
148KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00306977
149KDM2B_26808549_Chip-Seq_REH_Human0.97838793
150SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97805278
151CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97595760
152RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.97123101
153REST_21632747_ChIP-Seq_MESCs_Mouse0.96532219
154E2F7_22180533_ChIP-Seq_HELA_Human0.96442435
155CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96244949
156RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94666051
157* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94022977
158MYC_18358816_ChIP-ChIP_MESCs_Mouse0.93632483
159GABP_19822575_ChIP-Seq_HepG2_Human0.93157955
160ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.89902954
161KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.87287171
162KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.87287171
163KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.87287171
164GATA1_22025678_ChIP-Seq_K562_Human0.85139371
165DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.84032797
166DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.83379418
167STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.83292038
168VDR_21846776_ChIP-Seq_THP-1_Human0.80343625
169SALL4_18804426_ChIP-ChIP_XEN_Mouse0.79928955
170BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.77269272
171CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.76743374
172KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.76634592
173FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.76425378
174MYB_26560356_Chip-Seq_TH1_Human0.71910887
175GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.70235960
176EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.69318381
177TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.66076038
178SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.65973496
179SOX2_18555785_ChIP-Seq_MESCs_Mouse0.64242677
180ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.64241418
181TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.61684305
182CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.61662889
183NANOG_21062744_ChIP-ChIP_HESCs_Human0.59336166

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001188_hyperpigmentation4.20366170
2MP0008877_abnormal_DNA_methylation3.98444391
3MP0003111_abnormal_nucleus_morphology3.75246659
4MP0003077_abnormal_cell_cycle3.36040843
5MP0010352_gastrointestinal_tract_polyps3.19567947
6MP0003880_abnormal_central_pattern3.01563187
7MP0006292_abnormal_olfactory_placode2.96329144
8MP0003693_abnormal_embryo_hatching2.82331745
9MP0001986_abnormal_taste_sensitivity2.66241490
10MP0000566_synostosis2.59219402
11MP0003787_abnormal_imprinting2.58802514
12MP0005646_abnormal_pituitary_gland2.57050266
13MP0000537_abnormal_urethra_morphology2.54194722
14MP0001346_abnormal_lacrimal_gland2.40859994
15MP0004957_abnormal_blastocyst_morpholog2.37978003
16MP0003890_abnormal_embryonic-extraembry2.35289482
17MP0008058_abnormal_DNA_repair2.34524707
18MP0010307_abnormal_tumor_latency2.33815920
19MP0000516_abnormal_urinary_system2.18029708
20MP0005367_renal/urinary_system_phenotyp2.18029708
21MP0002876_abnormal_thyroid_physiology2.16833974
22MP0005171_absent_coat_pigmentation2.16757013
23MP0005409_darkened_coat_color2.15289368
24MP0005187_abnormal_penis_morphology2.13466493
25MP0001968_abnormal_touch/_nociception2.06243675
26MP0008932_abnormal_embryonic_tissue2.03995171
27MP0002736_abnormal_nociception_after2.03859485
28MP0009697_abnormal_copulation2.02875280
29MP0003136_yellow_coat_color2.01033492
30MP0009745_abnormal_behavioral_response1.93034305
31MP0001529_abnormal_vocalization1.92894572
32MP0000350_abnormal_cell_proliferation1.89093399
33MP0005076_abnormal_cell_differentiation1.88679473
34MP0008995_early_reproductive_senescence1.82635627
35MP0005623_abnormal_meninges_morphology1.80777867
36MP0008057_abnormal_DNA_replication1.80083832
37MP0002735_abnormal_chemical_nociception1.79306021
38MP0009046_muscle_twitch1.74262946
39MP0000015_abnormal_ear_pigmentation1.74259415
40MP0002572_abnormal_emotion/affect_behav1.70175425
41MP0002249_abnormal_larynx_morphology1.69951470
42MP0004808_abnormal_hematopoietic_stem1.67166847
43MP0002272_abnormal_nervous_system1.64969953
44MP0001905_abnormal_dopamine_level1.64022787
45MP0004859_abnormal_synaptic_plasticity1.63119637
46MP0003635_abnormal_synaptic_transmissio1.62253478
47MP0001672_abnormal_embryogenesis/_devel1.61114626
48MP0005380_embryogenesis_phenotype1.61114626
49MP0004270_analgesia1.58160529
50MP0002210_abnormal_sex_determination1.57313656
51MP0003941_abnormal_skin_development1.56358159
52MP0001730_embryonic_growth_arrest1.56056364
53MP0003121_genomic_imprinting1.54630157
54MP0002064_seizures1.53846470
55MP0001984_abnormal_olfaction1.53535357
56MP0008260_abnormal_autophagy1.52151064
57MP0002063_abnormal_learning/memory/cond1.51335556
58MP0002067_abnormal_sensory_capabilities1.51218806
59MP0002084_abnormal_developmental_patter1.50538840
60MP0005075_abnormal_melanosome_morpholog1.49949756
61MP0003984_embryonic_growth_retardation1.48834344
62MP0003879_abnormal_hair_cell1.48309356
63MP0001486_abnormal_startle_reflex1.46551872
64MP0003786_premature_aging1.45758880
65MP0005379_endocrine/exocrine_gland_phen1.45495035
66MP0010094_abnormal_chromosome_stability1.44400917
67MP0003937_abnormal_limbs/digits/tail_de1.43977876
68MP0006276_abnormal_autonomic_nervous1.43346682
69MP0002088_abnormal_embryonic_growth/wei1.41957259
70MP0002160_abnormal_reproductive_system1.41623887
71MP0001661_extended_life_span1.40620811
72MP0004142_abnormal_muscle_tone1.40334306
73MP0003315_abnormal_perineum_morphology1.39920099
74MP0002734_abnormal_mechanical_nocicepti1.39200103
75MP0001697_abnormal_embryo_size1.37507707
76MP0008961_abnormal_basal_metabolism1.36253303
77MP0002277_abnormal_respiratory_mucosa1.34607914
78MP0002166_altered_tumor_susceptibility1.32701389
79MP0000372_irregular_coat_pigmentation1.32248882
80MP0004185_abnormal_adipocyte_glucose1.32012975
81MP0002095_abnormal_skin_pigmentation1.30000436
82MP0002085_abnormal_embryonic_tissue1.28762422
83MP0001929_abnormal_gametogenesis1.28425454
84MP0003122_maternal_imprinting1.26926962
85MP0002102_abnormal_ear_morphology1.26861927
86MP0004147_increased_porphyrin_level1.25061975
87MP0002163_abnormal_gland_morphology1.22866334
88MP0002822_catalepsy1.22121235
89MP0002086_abnormal_extraembryonic_tissu1.21510085
90MP0008007_abnormal_cellular_replicative1.18887685
91MP0005645_abnormal_hypothalamus_physiol1.17874179
92MP0004381_abnormal_hair_follicle1.17390450
93MP0003698_abnormal_male_reproductive1.16902889
94MP0000313_abnormal_cell_death1.16868460
95MP0003646_muscle_fatigue1.16206357
96MP0002697_abnormal_eye_size1.15851615
97MP0000681_abnormal_thyroid_gland1.13974262
98MP0003718_maternal_effect1.13339923
99MP0002751_abnormal_autonomic_nervous1.13288505
100MP0002080_prenatal_lethality1.13242895
101MP0008789_abnormal_olfactory_epithelium1.12812635
102MP0000778_abnormal_nervous_system1.12357115
103MP0000653_abnormal_sex_gland1.10561385
104MP0005386_behavior/neurological_phenoty1.09330588
105MP0004924_abnormal_behavior1.09330588
106MP0000003_abnormal_adipose_tissue1.08541818
107MP0003123_paternal_imprinting1.08433791
108MP0001145_abnormal_male_reproductive1.07717232
109MP0002877_abnormal_melanocyte_morpholog1.07090834
110MP0005551_abnormal_eye_electrophysiolog1.07015089
111MP0000631_abnormal_neuroendocrine_gland1.04814342
112MP0005499_abnormal_olfactory_system1.04336293
113MP0005394_taste/olfaction_phenotype1.04336293
114MP0001963_abnormal_hearing_physiology1.03762853
115MP0002092_abnormal_eye_morphology1.02380582
116MP0003942_abnormal_urinary_system1.00768977
117MP0002557_abnormal_social/conspecific_i1.00708702
118MP0001119_abnormal_female_reproductive1.00204328
119MP0002009_preneoplasia0.98810843
120MP0010386_abnormal_urinary_bladder0.98685596
121MP0004197_abnormal_fetal_growth/weight/0.98277169
122MP0001286_abnormal_eye_development0.97993875
123MP0005389_reproductive_system_phenotype0.97983926
124MP0004233_abnormal_muscle_weight0.96642697
125MP0000026_abnormal_inner_ear0.95783340
126MP0004742_abnormal_vestibular_system0.94593649
127MP0002184_abnormal_innervation0.93860086
128MP0009250_abnormal_appendicular_skeleto0.93793041
129MP0002006_tumorigenesis0.93218411
130MP0002837_dystrophic_cardiac_calcinosis0.91954945
131MP0001293_anophthalmia0.91374151
132MP0003935_abnormal_craniofacial_develop0.90136751
133MP0008569_lethality_at_weaning0.86457499
134MP0003183_abnormal_peptide_metabolism0.86394625
135MP0000569_abnormal_digit_pigmentation0.85080564
136MP0009053_abnormal_anal_canal0.84558112
137MP0000428_abnormal_craniofacial_morphol0.84131916
138MP0001501_abnormal_sleep_pattern0.84048279
139MP0002938_white_spotting0.83008940
140MP0000733_abnormal_muscle_development0.82057754
141MP0009703_decreased_birth_body0.81669725
142MP0002114_abnormal_axial_skeleton0.81504828
143MP0003705_abnormal_hypodermis_morpholog0.80648505
144MP0001970_abnormal_pain_threshold0.80032357
145MP0003763_abnormal_thymus_physiology0.79460514
146MP0002132_abnormal_respiratory_system0.78370886
147MP0002638_abnormal_pupillary_reflex0.78319322
148MP0003699_abnormal_female_reproductive0.77238235
149MP0000534_abnormal_ureter_morphology0.77219931
150MP0003943_abnormal_hepatobiliary_system0.76988892
151MP0002233_abnormal_nose_morphology0.76895505
152MP0004782_abnormal_surfactant_physiolog0.75857693
153MP0003221_abnormal_cardiomyocyte_apopto0.74658372
154MP0000703_abnormal_thymus_morphology0.73811670
155MP0009672_abnormal_birth_weight0.73111440
156MP0001919_abnormal_reproductive_system0.72660286
157MP0005647_abnormal_sex_gland0.72376234
158MP0000490_abnormal_crypts_of0.72325936
159MP0001186_pigmentation_phenotype0.71872261
160MP0001440_abnormal_grooming_behavior0.71729304
161MP0000432_abnormal_head_morphology0.71603315
162MP0002882_abnormal_neuron_morphology0.71142400
163MP0001915_intracranial_hemorrhage0.71020734
164MP0002396_abnormal_hematopoietic_system0.70392260
165MP0003828_pulmonary_edema0.70102681
166MP0005174_abnormal_tail_pigmentation0.69410978
167MP0000955_abnormal_spinal_cord0.68175612
168MP0002019_abnormal_tumor_incidence0.67704773
169MP0001177_atelectasis0.67590512
170MP0009115_abnormal_fat_cell0.66804991
171MP0005375_adipose_tissue_phenotype0.64844168
172MP0005621_abnormal_cell_physiology0.64350058
173MP0003861_abnormal_nervous_system0.63726263
174MP0002161_abnormal_fertility/fecundity0.63344813
175MP0003115_abnormal_respiratory_system0.62969474
176MP0010678_abnormal_skin_adnexa0.62250073

Predicted human phenotypes

RankGene SetZ-score
1Septate vagina (HP:0001153)4.96213226
2Febrile seizures (HP:0002373)4.82027302
3Focal motor seizures (HP:0011153)4.27177302
4Volvulus (HP:0002580)4.26559006
5Abnormal hair whorl (HP:0010721)4.18230414
6Atonic seizures (HP:0010819)3.65584078
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.43166549
8Abnormality of the fingertips (HP:0001211)3.34965820
9Hyperventilation (HP:0002883)3.32906992
10Type 2 muscle fiber atrophy (HP:0003554)3.32170986
11Neonatal hypoglycemia (HP:0001998)3.30072774
12Hypothermia (HP:0002045)3.23583710
13Chromsome breakage (HP:0040012)3.20426553
14Abnormality of cochlea (HP:0000375)3.17778108
15Pancreatic fibrosis (HP:0100732)3.12566600
16True hermaphroditism (HP:0010459)3.05743621
17Epileptic encephalopathy (HP:0200134)3.05659301
18Aplasia/Hypoplasia of the tibia (HP:0005772)2.97505969
19Abnormality of the phalanges of the hallux (HP:0010057)2.96359152
20Medial flaring of the eyebrow (HP:0010747)2.95375689
21Nonprogressive disorder (HP:0003680)2.93491423
22Dysmetric saccades (HP:0000641)2.93322850
23Abnormality of the labia minora (HP:0012880)2.91960067
24Nephrogenic diabetes insipidus (HP:0009806)2.89097364
25Abnormal number of incisors (HP:0011064)2.88697978
26Progressive muscle weakness (HP:0003323)2.88329878
27Ectopic kidney (HP:0000086)2.82323059
28Congenital primary aphakia (HP:0007707)2.79441707
29Azoospermia (HP:0000027)2.75188311
30Short tibia (HP:0005736)2.74887509
31Gait imbalance (HP:0002141)2.74681673
32Truncal obesity (HP:0001956)2.73113386
33Poor coordination (HP:0002370)2.69985164
34Deep philtrum (HP:0002002)2.68648728
35Acute myeloid leukemia (HP:0004808)2.66220865
36Abnormal spermatogenesis (HP:0008669)2.65616780
37Midline defect of the nose (HP:0004122)2.65243590
38Fair hair (HP:0002286)2.62591489
39Birth length less than 3rd percentile (HP:0003561)2.62294121
40Acute lymphatic leukemia (HP:0006721)2.62108224
41Abnormality of chromosome segregation (HP:0002916)2.57766968
42Muscle fiber atrophy (HP:0100295)2.53577287
43Transposition of the great arteries (HP:0001669)2.53489809
44Abnormal connection of the cardiac segments (HP:0011545)2.53489809
45Abnormal ventriculo-arterial connection (HP:0011563)2.53489809
46Supernumerary spleens (HP:0009799)2.53061029
47Proximal placement of thumb (HP:0009623)2.52898637
48Papillary thyroid carcinoma (HP:0002895)2.51529039
493-Methylglutaconic aciduria (HP:0003535)2.47782401
50Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.44540466
51Progressive external ophthalmoplegia (HP:0000590)2.39763372
52Protruding tongue (HP:0010808)2.39035817
53Deviation of the thumb (HP:0009603)2.35858295
54Gaze-evoked nystagmus (HP:0000640)2.31440845
55Absent radius (HP:0003974)2.29311015
56Abnormal pancreas size (HP:0012094)2.27907466
57Type I transferrin isoform profile (HP:0003642)2.27355532
58Vertebral arch anomaly (HP:0008438)2.26995853
59Abnormality of the distal phalanx of the thumb (HP:0009617)2.26781383
60Genital tract atresia (HP:0001827)2.25547206
61Cafe-au-lait spot (HP:0000957)2.25413223
62Patchy hypopigmentation of hair (HP:0011365)2.24939194
63Abnormality of incisor morphology (HP:0011063)2.24661255
64Persistence of primary teeth (HP:0006335)2.23569598
65Molar tooth sign on MRI (HP:0002419)2.22730060
66Abnormality of midbrain morphology (HP:0002418)2.22730060
67Calcaneovalgus deformity (HP:0001848)2.21747924
68Absent/shortened dynein arms (HP:0200106)2.21452043
69Dynein arm defect of respiratory motile cilia (HP:0012255)2.21452043
70Duplication of thumb phalanx (HP:0009942)2.20137034
71Heterotopia (HP:0002282)2.17828176
72Abnormality of the preputium (HP:0100587)2.16771915
73Short thumb (HP:0009778)2.16433945
74Duplicated collecting system (HP:0000081)2.16163816
75Broad-based gait (HP:0002136)2.15820410
76Chronic hepatic failure (HP:0100626)2.15815837
77Cubitus valgus (HP:0002967)2.15089209
78Sandal gap (HP:0001852)2.14965020
79Rectal prolapse (HP:0002035)2.14788739
80Generalized hypopigmentation of hair (HP:0011358)2.13418876
81Abnormality of DNA repair (HP:0003254)2.12297526
82High anterior hairline (HP:0009890)2.11776322
83Long eyelashes (HP:0000527)2.10358274
84Sloping forehead (HP:0000340)2.10266265
85Prominent nose (HP:0000448)2.10059045
86Vaginal atresia (HP:0000148)2.09856963
87Abnormality of the parietal bone (HP:0002696)2.09264700
88White forelock (HP:0002211)2.08956663
89Meckel diverticulum (HP:0002245)2.08664260
90Nephroblastoma (Wilms tumor) (HP:0002667)2.08076931
91Absent forearm bone (HP:0003953)2.07907250
92Aplasia involving forearm bones (HP:0009822)2.07907250
93Morphological abnormality of the inner ear (HP:0011390)2.07447684
94Spinal cord lesions (HP:0100561)2.07436776
95Syringomyelia (HP:0003396)2.07436776
96Intestinal fistula (HP:0100819)2.06266864
97Abnormal ciliary motility (HP:0012262)2.05130927
98Abnormal respiratory motile cilium physiology (HP:0012261)2.04703989
99Fetal akinesia sequence (HP:0001989)2.04634814
100Low anterior hairline (HP:0000294)2.03188439
101Narrow palate (HP:0000189)2.03079331
102Microvesicular hepatic steatosis (HP:0001414)2.02362766
103Pancreatic cysts (HP:0001737)2.02022636
104Abnormal lung lobation (HP:0002101)2.01545582
105Abnormal respiratory epithelium morphology (HP:0012253)2.00186011
106Abnormal respiratory motile cilium morphology (HP:0005938)2.00186011
107Abnormality of the ileum (HP:0001549)2.00181576
108Lip pit (HP:0100267)1.99946815
1092-3 toe syndactyly (HP:0004691)1.99656251
110Embryonal neoplasm (HP:0002898)1.98862286
111Medulloblastoma (HP:0002885)1.97363625
112Optic disc pallor (HP:0000543)1.97158193
113Abnormal foot bone ossification (HP:0010675)1.96912661
114Acute necrotizing encephalopathy (HP:0006965)1.96761373
115Embryonal renal neoplasm (HP:0011794)1.96431582
116Impulsivity (HP:0100710)1.95631089
117Nephronophthisis (HP:0000090)1.94533871
118Duodenal stenosis (HP:0100867)1.93853682
119Small intestinal stenosis (HP:0012848)1.93853682
120Optic nerve hypoplasia (HP:0000609)1.93741248
121Diastasis recti (HP:0001540)1.92604181
122Aplasia/Hypoplasia of the lens (HP:0008063)1.92546111
123Aganglionic megacolon (HP:0002251)1.91579458
124Neoplasm of the adrenal cortex (HP:0100641)1.91486125
125Arteriovenous malformation (HP:0100026)1.90830482
126Abnormality of the calcaneus (HP:0008364)1.90614207
127Ulnar bowing (HP:0003031)1.89521958
128Relative macrocephaly (HP:0004482)1.89119182
129Reticulocytopenia (HP:0001896)1.88900871
130Periauricular skin pits (HP:0100277)1.88511154
131Preauricular pit (HP:0004467)1.88511154
132Overlapping toe (HP:0001845)1.86971433
133Radioulnar synostosis (HP:0002974)1.85364671
134Abnormal mitochondria in muscle tissue (HP:0008316)1.84211572
135Preaxial hand polydactyly (HP:0001177)1.83635054
136Anal stenosis (HP:0002025)1.83411034
137Deformed tarsal bones (HP:0008119)1.83015711
138Urethral obstruction (HP:0000796)1.82689137
139Increased nuchal translucency (HP:0010880)1.82425288
140Thyroid carcinoma (HP:0002890)1.82352107
141Clubbing of toes (HP:0100760)1.81318822
142Short 5th finger (HP:0009237)1.81161311
143Postaxial foot polydactyly (HP:0001830)1.80504594
144Abnormality of the renal collecting system (HP:0004742)1.79737785
145Dry hair (HP:0011359)1.79615253
146Myelodysplasia (HP:0002863)1.79404840
147Abnormality of the fetal cardiovascular system (HP:0010948)1.78802486
148Abnormal umbilical cord blood vessels (HP:0011403)1.78802486
149Single umbilical artery (HP:0001195)1.78802486
150Hepatoblastoma (HP:0002884)1.78497682
151Abnormality of the columella (HP:0009929)1.78332821
152Prostate neoplasm (HP:0100787)1.77681100
153Aplasia/Hypoplasia of the uvula (HP:0010293)1.77626834
154Short middle phalanx of finger (HP:0005819)1.77500112
155Dialeptic seizures (HP:0011146)1.76954185
156Thick eyebrow (HP:0000574)1.76934489
157Ureteral duplication (HP:0000073)1.76672602
158Abnormality of chromosome stability (HP:0003220)1.76059882
159Limb hypertonia (HP:0002509)1.75892748
160Blue irides (HP:0000635)1.75751321
161Skin pits (HP:0100276)1.75546649
162Absence seizures (HP:0002121)1.75513105
163Intestinal atresia (HP:0011100)1.74278746
164Alveolar cell carcinoma (HP:0006519)1.74228784
165Progressive macrocephaly (HP:0004481)1.73628515
166Absent eyebrow (HP:0002223)1.72341795
167Abnormality of the axillary hair (HP:0100134)1.71633176
168Abnormality of secondary sexual hair (HP:0009888)1.71633176
169Dyschromatopsia (HP:0007641)1.71591760
170Thyroid-stimulating hormone excess (HP:0002925)1.71283603
171Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.71194542
172Mitochondrial inheritance (HP:0001427)1.70316354
173Scanning speech (HP:0002168)1.70126420
174Male pseudohermaphroditism (HP:0000037)1.68923066
175Progressive cerebellar ataxia (HP:0002073)1.68859998
176Submucous cleft hard palate (HP:0000176)1.67627111
177Broad foot (HP:0001769)1.67138633
178Median cleft lip (HP:0000161)1.66166045
179Abnormality of the nasal septum (HP:0000419)1.65582427
180Abnormality of the heme biosynthetic pathway (HP:0010472)1.63360413
181Hyperalaninemia (HP:0003348)1.61205672
182Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.61205672
183Abnormality of alanine metabolism (HP:0010916)1.61205672
184Focal seizures (HP:0007359)1.59427008

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK7.03746857
2CDK125.31141072
3BRD43.82067562
4LATS13.79756166
5AKT33.27475832
6MUSK2.92080627
7PRPF4B2.88179728
8CAMK1G2.84648329
9MKNK22.75236154
10TRIB32.68582145
11MAP3K122.57566637
12MAP2K72.51132995
13EEF2K2.48243348
14CAMK1D2.39453205
15CDK192.24850138
16PNCK2.21310189
17TTK2.16956934
18SRPK12.11457368
19MKNK11.99265234
20SGK21.96207218
21MAP3K101.94969011
22CHEK21.94725815
23YES11.93277110
24STK161.81069742
25BMPR1B1.77766543
26SIK31.75543076
27ACVR1B1.62842336
28ATR1.61355406
29LATS21.61017757
30MELK1.58205053
31CHEK11.57787737
32BMPR21.55438874
33MAPK131.51574299
34TSSK61.51119704
35ZAK1.50794631
36TXK1.48276776
37PLK21.45622069
38KSR21.42520969
39CCNB11.39940394
40SGK4941.37137556
41SGK2231.37137556
42CDK81.32795463
43VRK11.30120225
44NLK1.26536925
45ADRBK21.25673005
46PIM11.23419038
47TNIK1.21801432
48ICK1.21507988
49NTRK31.19131894
50NEK61.17235860
51STK31.17041175
52CDK61.16636471
53SGK31.16009488
54PLK41.15158915
55IRAK31.15057597
56TAOK21.14399936
57CDK41.11362454
58BRAF1.10280786
59RAF11.08533886
60PLK31.06741168
61SCYL21.05157422
62INSRR1.02703365
63CDC70.99219049
64IRAK20.97754592
65MAP2K60.96961010
66AURKB0.95990859
67CDK70.95734580
68MAP3K20.95732869
69ERBB30.95657049
70MTOR0.95405368
71OXSR10.94535390
72MST40.92111384
73CDK30.91860518
74DAPK10.91661278
75MAP3K140.90468697
76NEK20.89434826
77CDK20.89028756
78GRK10.87176472
79SMG10.84364378
80PINK10.83081383
81CAMKK20.81545047
82CDK10.79174402
83MAPKAPK50.77325862
84MAP3K60.76595023
85TRIM280.74684763
86PRKCE0.72986652
87CLK10.72025084
88TEC0.71824354
89STK240.69088439
90STK38L0.68950389
91MAPK110.67864729
92TNK20.65259142
93IRAK40.64980145
94GRK70.63315453
95MAP3K130.62075647
96STK40.61959048
97PRKAA20.61559816
98MAP3K40.60134634
99TLK10.59874829
100KSR10.59121883
101MAP2K20.58396165
102IRAK10.56857534
103BCR0.56592891
104AURKA0.56410933
105RPS6KB10.55990678
106NEK10.55914835
107PRKAA10.55122727
108MYLK0.55111513
109EIF2AK20.55005647
110BRSK20.54684721
111PASK0.53960415
112CAMK2A0.52900462
113MAPK140.51487446
114DYRK20.50588356
115GSK3B0.49582491
116NEK90.49207098
117EPHA40.48760977
118MAP2K30.47579456
119RPS6KB20.47483291
120CDK90.47301856
121AKT20.45886427
122PRKCG0.45880117
123SGK10.44487358
124CAMK2B0.44464915
125PDK20.44177576
126PLK10.43807410
127MAPK100.43002710
128RPS6KA10.42526284
129MAP3K90.42136892
130PRKDC0.41046382
131GRK50.40721041
132NUAK10.39139353
133TAF10.38548138
134ADRBK10.37142131
135MAP2K40.36866160
136BUB10.35366651
137RPS6KA50.35013977
138RIPK40.33359575
139CAMK40.33270581
140MAPK10.33051817
141DYRK1A0.32069262
142AKT10.31825132
143MINK10.31049707
144DAPK20.30704630
145EIF2AK30.30406458
146PDK30.29450322
147PDK40.29450322
148NME10.29437084
149CSNK1A1L0.29202633
150MARK30.28817926
151CSNK1G10.28339095
152KIT0.25798172
153ATM0.24342822
154PKN10.24106418
155WEE10.23873344
156CSF1R0.23749412
157BRSK10.23273136
158FRK0.23238084
159WNK10.22638280
160CSNK2A10.22584701
161TRPM70.22004238

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.05833228
2Nicotine addiction_Homo sapiens_hsa050332.80705626
3Basal transcription factors_Homo sapiens_hsa030222.50177444
4Collecting duct acid secretion_Homo sapiens_hsa049662.44239430
5Phototransduction_Homo sapiens_hsa047442.41780570
6Homologous recombination_Homo sapiens_hsa034402.39116919
7Fanconi anemia pathway_Homo sapiens_hsa034602.34432568
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.27572938
9RNA polymerase_Homo sapiens_hsa030202.24350163
10Synaptic vesicle cycle_Homo sapiens_hsa047212.15737834
11Longevity regulating pathway - multiple species_Homo sapiens_hsa042132.10653300
12SNARE interactions in vesicular transport_Homo sapiens_hsa041302.05287924
13Olfactory transduction_Homo sapiens_hsa047401.93017145
14Lysine degradation_Homo sapiens_hsa003101.91675569
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.84920875
16p53 signaling pathway_Homo sapiens_hsa041151.77619656
17One carbon pool by folate_Homo sapiens_hsa006701.74745434
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.74143041
19Chronic myeloid leukemia_Homo sapiens_hsa052201.73069019
20Longevity regulating pathway - mammal_Homo sapiens_hsa042111.72532757
21RNA degradation_Homo sapiens_hsa030181.69166917
22Non-homologous end-joining_Homo sapiens_hsa034501.68273027
23MicroRNAs in cancer_Homo sapiens_hsa052061.68233957
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.63094246
25Protein export_Homo sapiens_hsa030601.56970177
26Morphine addiction_Homo sapiens_hsa050321.56435742
27Serotonergic synapse_Homo sapiens_hsa047261.52843950
28Taste transduction_Homo sapiens_hsa047421.49484913
29Non-small cell lung cancer_Homo sapiens_hsa052231.47506947
30Prostate cancer_Homo sapiens_hsa052151.44424539
31Pancreatic cancer_Homo sapiens_hsa052121.44246795
32TGF-beta signaling pathway_Homo sapiens_hsa043501.43124675
33Proteasome_Homo sapiens_hsa030501.40252060
34Colorectal cancer_Homo sapiens_hsa052101.37974693
35Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.37719055
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.37569501
37Vitamin B6 metabolism_Homo sapiens_hsa007501.35943542
38Viral carcinogenesis_Homo sapiens_hsa052031.33607904
39Circadian entrainment_Homo sapiens_hsa047131.32923073
40Base excision repair_Homo sapiens_hsa034101.32173962
41Rheumatoid arthritis_Homo sapiens_hsa053231.31984219
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.31800773
43Vibrio cholerae infection_Homo sapiens_hsa051101.30189351
44Cell cycle_Homo sapiens_hsa041101.30135221
45Systemic lupus erythematosus_Homo sapiens_hsa053221.28115513
46Amphetamine addiction_Homo sapiens_hsa050311.26729051
47Purine metabolism_Homo sapiens_hsa002301.26279243
48Nucleotide excision repair_Homo sapiens_hsa034201.26214939
49Glutamatergic synapse_Homo sapiens_hsa047241.24754379
50Selenocompound metabolism_Homo sapiens_hsa004501.23698738
51Dorso-ventral axis formation_Homo sapiens_hsa043201.21711649
52Long-term depression_Homo sapiens_hsa047301.20914017
53DNA replication_Homo sapiens_hsa030301.20891221
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.20098447
55Type II diabetes mellitus_Homo sapiens_hsa049301.19498188
56Small cell lung cancer_Homo sapiens_hsa052221.19470648
57Adipocytokine signaling pathway_Homo sapiens_hsa049201.18739024
58Long-term potentiation_Homo sapiens_hsa047201.17371742
59Mismatch repair_Homo sapiens_hsa034301.14060202
60Acute myeloid leukemia_Homo sapiens_hsa052211.13979882
61Sphingolipid metabolism_Homo sapiens_hsa006001.09351679
62Hepatitis B_Homo sapiens_hsa051611.07586076
63Oxidative phosphorylation_Homo sapiens_hsa001901.04910366
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.04409024
65GABAergic synapse_Homo sapiens_hsa047271.03500341
66mTOR signaling pathway_Homo sapiens_hsa041501.03261340
67Thyroid hormone signaling pathway_Homo sapiens_hsa049191.03160726
68Bladder cancer_Homo sapiens_hsa052191.02109060
69Renal cell carcinoma_Homo sapiens_hsa052111.01430041
70Pyrimidine metabolism_Homo sapiens_hsa002401.01422591
71Thyroid cancer_Homo sapiens_hsa052160.99405088
72Endometrial cancer_Homo sapiens_hsa052130.97876354
73Glioma_Homo sapiens_hsa052140.97605233
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97195750
75Dopaminergic synapse_Homo sapiens_hsa047280.95532206
76Asthma_Homo sapiens_hsa053100.95051298
77Fatty acid elongation_Homo sapiens_hsa000620.94151692
78Regulation of autophagy_Homo sapiens_hsa041400.91338944
79AMPK signaling pathway_Homo sapiens_hsa041520.91274523
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90922926
81Type I diabetes mellitus_Homo sapiens_hsa049400.90399144
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89740962
83HTLV-I infection_Homo sapiens_hsa051660.89650494
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.89160647
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87012278
86Calcium signaling pathway_Homo sapiens_hsa040200.86957087
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86670845
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86527659
89Cysteine and methionine metabolism_Homo sapiens_hsa002700.85732355
90Arachidonic acid metabolism_Homo sapiens_hsa005900.81438159
91Ether lipid metabolism_Homo sapiens_hsa005650.81014083
92mRNA surveillance pathway_Homo sapiens_hsa030150.80710582
93Allograft rejection_Homo sapiens_hsa053300.79742969
94ErbB signaling pathway_Homo sapiens_hsa040120.79316105
95Autoimmune thyroid disease_Homo sapiens_hsa053200.78298303
96Cocaine addiction_Homo sapiens_hsa050300.77383962
97Huntingtons disease_Homo sapiens_hsa050160.77085923
98RNA transport_Homo sapiens_hsa030130.74062658
99Insulin signaling pathway_Homo sapiens_hsa049100.73249826
100Circadian rhythm_Homo sapiens_hsa047100.72877783
101Apoptosis_Homo sapiens_hsa042100.71905458
102Parkinsons disease_Homo sapiens_hsa050120.71480755
103Spliceosome_Homo sapiens_hsa030400.71468253
104B cell receptor signaling pathway_Homo sapiens_hsa046620.70726401
105Phagosome_Homo sapiens_hsa041450.69850056
106Intestinal immune network for IgA production_Homo sapiens_hsa046720.68634326
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.66721799
108Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65727406
109Adherens junction_Homo sapiens_hsa045200.65162738
110RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64683967
111Choline metabolism in cancer_Homo sapiens_hsa052310.64470468
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.64039528
113Herpes simplex infection_Homo sapiens_hsa051680.63678768
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62884512
115Hedgehog signaling pathway_Homo sapiens_hsa043400.62388587
116Prolactin signaling pathway_Homo sapiens_hsa049170.62164282
117Influenza A_Homo sapiens_hsa051640.59718323
118Cholinergic synapse_Homo sapiens_hsa047250.59564558
119Oocyte meiosis_Homo sapiens_hsa041140.59448622
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57453573
121Ovarian steroidogenesis_Homo sapiens_hsa049130.56931011
122Hippo signaling pathway_Homo sapiens_hsa043900.55397636
123Melanoma_Homo sapiens_hsa052180.54387988
124Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53664766
125Salivary secretion_Homo sapiens_hsa049700.53471544
126Insulin secretion_Homo sapiens_hsa049110.51855887
127Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51330285
128Epstein-Barr virus infection_Homo sapiens_hsa051690.50117723
129cAMP signaling pathway_Homo sapiens_hsa040240.48262117
130Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.48150050
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47920503
132Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47846073
133Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47015095
134Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46858467
135Renin secretion_Homo sapiens_hsa049240.45449467
136cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45284938
137Inositol phosphate metabolism_Homo sapiens_hsa005620.45009943
138Wnt signaling pathway_Homo sapiens_hsa043100.44648381
139MAPK signaling pathway_Homo sapiens_hsa040100.44404437
140Alcoholism_Homo sapiens_hsa050340.44316472
141NF-kappa B signaling pathway_Homo sapiens_hsa040640.43515452
142Glucagon signaling pathway_Homo sapiens_hsa049220.43510927
143Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42643058
144Ras signaling pathway_Homo sapiens_hsa040140.40456087
145TNF signaling pathway_Homo sapiens_hsa046680.40359327
146NOD-like receptor signaling pathway_Homo sapiens_hsa046210.40289948
147Pathways in cancer_Homo sapiens_hsa052000.39889466
148Estrogen signaling pathway_Homo sapiens_hsa049150.39815666
149VEGF signaling pathway_Homo sapiens_hsa043700.39428457
150AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39414773
151Measles_Homo sapiens_hsa051620.38652896
152Linoleic acid metabolism_Homo sapiens_hsa005910.37987454
153Alzheimers disease_Homo sapiens_hsa050100.37549487
154Sphingolipid signaling pathway_Homo sapiens_hsa040710.36165958
155T cell receptor signaling pathway_Homo sapiens_hsa046600.35653700
156Hematopoietic cell lineage_Homo sapiens_hsa046400.34671665
157Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34233664
158Jak-STAT signaling pathway_Homo sapiens_hsa046300.33727855
159FoxO signaling pathway_Homo sapiens_hsa040680.31755353
160Insulin resistance_Homo sapiens_hsa049310.31452789
161Fatty acid biosynthesis_Homo sapiens_hsa000610.31228894
162Basal cell carcinoma_Homo sapiens_hsa052170.31137076
163HIF-1 signaling pathway_Homo sapiens_hsa040660.27812708
164Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.26956077

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