KLHL14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the Kelch-like gene family, whose members contain a BTB/POZ domain, a BACK domain, and several Kelch domains. The encoded protein possesses six Kelch domains and localizes to the endoplasmic reticulum, where it interacts with torsin-1A. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1B cell receptor signaling pathway (GO:0050853)7.76415796
2thyroid hormone generation (GO:0006590)7.16506026
3plasma lipoprotein particle assembly (GO:0034377)7.05613226
4very-low-density lipoprotein particle assembly (GO:0034379)6.50744685
5negative regulation of fibrinolysis (GO:0051918)6.22973702
6protein-lipid complex assembly (GO:0065005)5.99661289
7thyroid hormone metabolic process (GO:0042403)5.81521772
8antigen processing and presentation of endogenous antigen (GO:0019883)5.67283720
9B cell proliferation (GO:0042100)5.54977263
10negative regulation of synaptic transmission, GABAergic (GO:0032229)5.48989391
11low-density lipoprotein particle remodeling (GO:0034374)5.46479527
12cellular response to zinc ion (GO:0071294)5.38245198
13regulation of apoptotic cell clearance (GO:2000425)5.30353416
14C21-steroid hormone biosynthetic process (GO:0006700)5.29018535
15regulation of fibrinolysis (GO:0051917)4.94862481
16intestinal cholesterol absorption (GO:0030299)4.84867608
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.78459007
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.78459007
19plasma lipoprotein particle organization (GO:0071827)4.68669267
20cholesterol efflux (GO:0033344)4.64383438
21regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.61450862
22synaptic vesicle docking involved in exocytosis (GO:0016081)4.58171010
23positive regulation of gamma-delta T cell activation (GO:0046645)4.56577251
24response to parathyroid hormone (GO:0071107)4.52602544
25glucocorticoid biosynthetic process (GO:0006704)4.52153987
26serine transport (GO:0032329)4.51011381
27peptidyl-glutamic acid carboxylation (GO:0017187)4.48171588
28protein carboxylation (GO:0018214)4.48171588
29L-serine transport (GO:0015825)4.46545161
30plasma lipoprotein particle remodeling (GO:0034369)4.46251875
31protein-lipid complex remodeling (GO:0034368)4.46251875
32macromolecular complex remodeling (GO:0034367)4.46251875
33regulation of protein activation cascade (GO:2000257)4.45963982
34regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)4.44811218
35regulation of complement activation (GO:0030449)4.40558131
36protein-lipid complex subunit organization (GO:0071825)4.25237541
37regulation of non-canonical Wnt signaling pathway (GO:2000050)4.25194144
38regulation of cholesterol esterification (GO:0010872)4.22675333
39regulation of platelet aggregation (GO:0090330)4.22130264
40presynaptic membrane assembly (GO:0097105)4.13331138
41regulation of B cell differentiation (GO:0045577)4.05971611
42synaptic vesicle exocytosis (GO:0016079)4.03709933
43regulation of gamma-delta T cell differentiation (GO:0045586)3.91188791
44positive regulation of dendritic spine morphogenesis (GO:0061003)3.83434369
45diacylglycerol metabolic process (GO:0046339)3.81912292
46glucocorticoid metabolic process (GO:0008211)3.81323588
47high-density lipoprotein particle remodeling (GO:0034375)3.79925976
48regulation of synaptic vesicle exocytosis (GO:2000300)3.77295371
49regulation of B cell receptor signaling pathway (GO:0050855)3.76540546
50pre-miRNA processing (GO:0031054)3.74460628
51blood coagulation, intrinsic pathway (GO:0007597)3.73147473
52positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.68595487
53glutamate secretion (GO:0014047)3.63540043
54negative regulation of sodium ion transport (GO:0010766)3.62996924
55reverse cholesterol transport (GO:0043691)3.61830301
56positive regulation of B cell differentiation (GO:0045579)3.61344751
57estrogen biosynthetic process (GO:0006703)3.60391072
58regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.59749357
59regulation of gamma-delta T cell activation (GO:0046643)3.58134665
60regulation of glutamate receptor signaling pathway (GO:1900449)3.54731267
61histone H3-K9 demethylation (GO:0033169)3.53999114
62regulation of bile acid biosynthetic process (GO:0070857)3.49360080
63locomotory exploration behavior (GO:0035641)3.49005563
64presynaptic membrane organization (GO:0097090)3.48321986
65negative regulation of histone methylation (GO:0031061)3.47734528
66positive regulation of developmental pigmentation (GO:0048087)3.46643280
67regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.44802819
68plasma lipoprotein particle clearance (GO:0034381)3.44618495
69antigen processing and presentation via MHC class Ib (GO:0002475)3.40601979
70nephron tubule morphogenesis (GO:0072078)3.40547457
71nephron epithelium morphogenesis (GO:0072088)3.40547457
72lung epithelium development (GO:0060428)3.40183891
73positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.38932411
74transferrin transport (GO:0033572)3.34220298
75positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.33781859
76vocalization behavior (GO:0071625)3.33722989
77neuron cell-cell adhesion (GO:0007158)3.32030510
78neurotransmitter-gated ion channel clustering (GO:0072578)3.30196482
79histone H3-K36 demethylation (GO:0070544)3.30064749
80positive regulation of peptidyl-threonine phosphorylation (GO:0010800)3.29027292
81mitochondrion distribution (GO:0048311)3.27414569
82C21-steroid hormone metabolic process (GO:0008207)3.26608868
83layer formation in cerebral cortex (GO:0021819)3.25133687
84positive regulation of bone resorption (GO:0045780)3.24835931
85positive regulation of bone remodeling (GO:0046852)3.24835931
86lipoprotein transport (GO:0042953)3.23803233
87long-term synaptic potentiation (GO:0060291)3.21721400
88positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)3.17984837
89intestinal absorption (GO:0050892)3.17777247
90cell proliferation involved in metanephros development (GO:0072203)3.16990306
91neurotransmitter secretion (GO:0007269)3.16137418
92negative regulation of cholesterol transport (GO:0032375)3.15143719
93negative regulation of sterol transport (GO:0032372)3.15143719
94peristalsis (GO:0030432)3.15073758
95ferric iron transport (GO:0015682)3.13531169
96trivalent inorganic cation transport (GO:0072512)3.13531169
97regulation of synaptic vesicle transport (GO:1902803)3.13124920
98regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.12372103
99postsynaptic membrane organization (GO:0001941)3.11997684
100phospholipid efflux (GO:0033700)3.11549308
101embryonic retina morphogenesis in camera-type eye (GO:0060059)3.07087597
102regulation of synaptic transmission, GABAergic (GO:0032228)3.06753320
103triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.06197254
104negative regulation of calcium ion transport into cytosol (GO:0010523)3.04527644
105positive regulation of DNA-templated transcription, initiation (GO:2000144)3.03903886
106regulation of humoral immune response (GO:0002920)3.03023097
107mechanosensory behavior (GO:0007638)3.00690031
108androgen biosynthetic process (GO:0006702)3.00536072
109histone H3-K9 methylation (GO:0051567)3.00060163
110positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.99304781
111cell proliferation involved in kidney development (GO:0072111)2.97381953
112heterochromatin organization (GO:0070828)2.97197306
113histone H2B ubiquitination (GO:0033523)2.97031797
114V(D)J recombination (GO:0033151)2.91819669
115histamine secretion (GO:0001821)2.91806051
116positive regulation of hormone metabolic process (GO:0032352)2.91464737
117positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.91096591
118NADH metabolic process (GO:0006734)2.91079273
119histone lysine demethylation (GO:0070076)2.90744833
120negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.87171988
121histone demethylation (GO:0016577)2.87026471
122regulation of cholesterol biosynthetic process (GO:0045540)2.86268604
123regulation of histone H3-K9 methylation (GO:0051570)2.85390585
124negative regulation of protein activation cascade (GO:2000258)2.84113879
125mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.82881904
126regulation of somitogenesis (GO:0014807)2.82157811
127centrosome localization (GO:0051642)2.80433958
128histone H3-K9 modification (GO:0061647)2.79941958
129hormone biosynthetic process (GO:0042446)2.75513930
130ATP hydrolysis coupled proton transport (GO:0015991)2.75430448
131energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.75430448
132protein localization to synapse (GO:0035418)2.74994969
133B cell homeostasis (GO:0001782)2.74382929
134SMAD protein signal transduction (GO:0060395)2.74320184
135regulation of B cell proliferation (GO:0030888)2.74036447
136ionotropic glutamate receptor signaling pathway (GO:0035235)2.73770375
137cellular sodium ion homeostasis (GO:0006883)2.73696179
138positive regulation of dendrite morphogenesis (GO:0050775)2.72873619
139regulation of cholesterol homeostasis (GO:2000188)2.72599286
140tachykinin receptor signaling pathway (GO:0007217)2.72250423
141regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.72017518
142regulation of short-term neuronal synaptic plasticity (GO:0048172)2.71906241
143regulation of norepinephrine secretion (GO:0014061)2.69817057
144regulation of synaptic transmission, glutamatergic (GO:0051966)2.69631318
145cellular response to ammonium ion (GO:0071242)2.69426149
146thyroid gland development (GO:0030878)2.69014098
147CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.68720092
148cochlea development (GO:0090102)2.67159460
149monoubiquitinated protein deubiquitination (GO:0035520)2.65786029
150positive regulation of mast cell degranulation (GO:0043306)2.65204820
151positive regulation of mast cell activation involved in immune response (GO:0033008)2.65204820
152pyrimidine ribonucleoside catabolic process (GO:0046133)2.64840242
153dorsal/ventral axis specification (GO:0009950)2.64393955
154lymph vessel development (GO:0001945)2.64173620
155exploration behavior (GO:0035640)2.64144590
156positive regulation of chemokine secretion (GO:0090197)2.63983363
157cellular hyperosmotic response (GO:0071474)2.63185400
158lipoprotein metabolic process (GO:0042157)2.62623181
159regulation of germinal center formation (GO:0002634)2.62473773
160regulation of plasminogen activation (GO:0010755)2.62255058
161low-density lipoprotein particle clearance (GO:0034383)2.62209655
162positive regulation of synapse maturation (GO:0090129)2.60813289
163vesicle targeting (GO:0006903)2.60418258
164cellular anion homeostasis (GO:0030002)2.60387345
165renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.60061272
166N-glycan processing (GO:0006491)2.59588610
167negative regulation of myeloid cell apoptotic process (GO:0033033)2.59511413
168negative regulation of norepinephrine secretion (GO:0010700)2.59269771
169cellular response to cadmium ion (GO:0071276)2.59224101
170antigen receptor-mediated signaling pathway (GO:0050851)2.59217211
171regulation of synapse maturation (GO:0090128)2.58588899
172negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.58543620
173negative regulation of translation, ncRNA-mediated (GO:0040033)2.58543620
174regulation of translation, ncRNA-mediated (GO:0045974)2.58543620
175mesenchymal cell proliferation (GO:0010463)2.58445685
176innervation (GO:0060384)2.57691054
177startle response (GO:0001964)2.57599624
178regulation of superoxide anion generation (GO:0032928)2.57330979
179auditory receptor cell differentiation (GO:0042491)2.57237033
180regulation of stem cell maintenance (GO:2000036)2.55361795
181lymphocyte proliferation (GO:0046651)2.54920642
182regulation of skeletal muscle cell differentiation (GO:2001014)2.54476771
183positive regulation of CREB transcription factor activity (GO:0032793)2.52805505
184response to histamine (GO:0034776)2.52652119
185regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.52622294
186renal tubule morphogenesis (GO:0061333)2.52223688
187gamma-aminobutyric acid signaling pathway (GO:0007214)2.51343008
188neutrophil activation (GO:0042119)2.51242988
189mononuclear cell proliferation (GO:0032943)2.50925207
190specification of organ identity (GO:0010092)2.50507631
191body morphogenesis (GO:0010171)2.50182657
192negative regulation of astrocyte differentiation (GO:0048712)2.49289049
193regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.48930784

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.01907591
2FOXA2_19822575_ChIP-Seq_HepG2_Human4.34424147
3CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.31987813
4GBX2_23144817_ChIP-Seq_PC3_Human3.69283014
5IKZF1_21737484_ChIP-ChIP_HCT116_Human3.61265794
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.45405257
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.80904798
8MYC_22102868_ChIP-Seq_BL_Human2.72502233
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.69716074
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.62922196
11HNF4A_19822575_ChIP-Seq_HepG2_Human2.56668483
12TAF15_26573619_Chip-Seq_HEK293_Human2.48578637
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.46364696
14PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.32450728
15VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.28443805
16* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.23223897
17TP63_19390658_ChIP-ChIP_HaCaT_Human2.22152763
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.20895880
19AR_21572438_ChIP-Seq_LNCaP_Human2.17144488
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.14443896
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.09605144
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.08003633
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.06845908
24* IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.05680510
25SMAD_19615063_ChIP-ChIP_OVARY_Human2.04567733
26* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.00522988
27* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98925944
28NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.97008988
29* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.96645126
30FUS_26573619_Chip-Seq_HEK293_Human1.95913243
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.93602938
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.91407555
33STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.88842351
34FOXO3_23340844_ChIP-Seq_DLD1_Human1.88403048
35GATA1_22025678_ChIP-Seq_K562_Human1.87198043
36* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.83304083
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.80657289
38* P300_19829295_ChIP-Seq_ESCs_Human1.80489558
39SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.76939926
40RNF2_27304074_Chip-Seq_NSC_Mouse1.76246758
41ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.75255002
42REST_21632747_ChIP-Seq_MESCs_Mouse1.74681015
43* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74020051
44LXR_22158963_ChIP-Seq_LIVER_Mouse1.73033369
45NANOG_21062744_ChIP-ChIP_HESCs_Human1.69968776
46IGF1R_20145208_ChIP-Seq_DFB_Human1.68851892
47RNF2_27304074_Chip-Seq_ESCs_Mouse1.68169222
48* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.68098993
49* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.68098993
50FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.67373404
51DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.64429289
52RXR_22158963_ChIP-Seq_LIVER_Mouse1.63842772
53SMAD4_21799915_ChIP-Seq_A2780_Human1.63837974
54SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.62171476
55SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.60172802
56TP53_16413492_ChIP-PET_HCT116_Human1.57679120
57PPARA_22158963_ChIP-Seq_LIVER_Mouse1.54862400
58CTNNB1_20460455_ChIP-Seq_HCT116_Human1.54831767
59* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.54533169
60EED_16625203_ChIP-ChIP_MESCs_Mouse1.52992724
61RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.52576701
62JARID2_20075857_ChIP-Seq_MESCs_Mouse1.51183493
63ARNT_22903824_ChIP-Seq_MCF-7_Human1.50818267
64ISL1_27105846_Chip-Seq_CPCs_Mouse1.50538204
65* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.50071814
66RUNX_20019798_ChIP-Seq_JUKART_Human1.49733714
67POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48969888
68REST_18959480_ChIP-ChIP_MESCs_Mouse1.48368479
69DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.48348072
70SOX2_21211035_ChIP-Seq_LN229_Gbm1.48321192
71AHR_22903824_ChIP-Seq_MCF-7_Human1.42173038
72* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.40888985
73RARB_27405468_Chip-Seq_BRAIN_Mouse1.40518531
74TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.39543658
75AR_25329375_ChIP-Seq_VCAP_Human1.38719125
76* PIAS1_25552417_ChIP-Seq_VCAP_Human1.38528859
77CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.37873154
78* EZH2_27304074_Chip-Seq_ESCs_Mouse1.37706995
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37623391
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37623391
81KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.36676429
82FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.34224446
83DROSHA_22980978_ChIP-Seq_HELA_Human1.32841471
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32144696
85CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.31815859
86CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30954848
87* EZH2_27294783_Chip-Seq_ESCs_Mouse1.29463677
88CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29461731
89TCF4_23295773_ChIP-Seq_U87_Human1.26979070
90KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.26449384
91CBX2_27304074_Chip-Seq_ESCs_Mouse1.25188613
92ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23974604
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.23473419
94POU5F1_16518401_ChIP-PET_MESCs_Mouse1.22946311
95FOXM1_23109430_ChIP-Seq_U2OS_Human1.21857181
96DNAJC2_21179169_ChIP-ChIP_NT2_Human1.20488125
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19644821
98P53_22127205_ChIP-Seq_FIBROBLAST_Human1.18288951
99ZNF274_21170338_ChIP-Seq_K562_Hela1.18183735
100CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.18176800
101AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17701156
102EWS_26573619_Chip-Seq_HEK293_Human1.17021793
103PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16808698
104MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15324447
105TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13820015
106TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13262478
107ZFP281_18757296_ChIP-ChIP_E14_Mouse1.11906354
108* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11706998
109ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11605861
110* STAT3_23295773_ChIP-Seq_U87_Human1.11400899
111NANOG_18555785_Chip-Seq_ESCs_Mouse1.11378235
112EP300_21415370_ChIP-Seq_HL-1_Mouse1.11140341
113TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.11024043
114WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10593815
115SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10482984
116PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.10320607
117VDR_21846776_ChIP-Seq_THP-1_Human1.09747189
118FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.09493163
119AR_19668381_ChIP-Seq_PC3_Human1.08140783
120ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07696616
121NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05197323
122KDM2B_26808549_Chip-Seq_REH_Human1.04888536
123RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.03730361
124SMAD3_21741376_ChIP-Seq_EPCs_Human1.03168031
125SOX9_26525672_Chip-Seq_HEART_Mouse1.02286595
126YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01830856
127FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.01709506
128WDR5_24793694_ChIP-Seq_LNCAP_Human1.01671076
129* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01194843
130NFIB_24661679_ChIP-Seq_LUNG_Mouse1.01169515
131CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00615379
132ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.00354780
133CIITA_25753668_ChIP-Seq_RAJI_Human1.00317604
134RUNX2_22187159_ChIP-Seq_PCA_Human1.00300976
135EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00163343
136ZFP281_27345836_Chip-Seq_ESCs_Mouse0.99752205
137PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.98965216
138SMRT_27268052_Chip-Seq_Bcells_Human0.98672952
139SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97295135
140P53_22387025_ChIP-Seq_ESCs_Mouse0.96843800
141ELK4_26923725_Chip-Seq_MESODERM_Mouse0.96093384
142HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.95705815
143E2F1_21310950_ChIP-Seq_MCF-7_Human0.94681267
144TCF4_18268006_ChIP-ChIP_LS174T_Human0.94599633
145TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94262484
146NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.93781498
147NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91552309
148EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.91486343
149SALL4_18804426_ChIP-ChIP_XEN_Mouse0.90359475
150CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90005154
151RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89813464
152TCF3_18692474_ChIP-Seq_MESCs_Mouse0.89718683
153WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86140177
154SOX3_22085726_ChIP-Seq_NPCs_Mouse0.85463805
155SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.84794523
156* RING1B_27294783_Chip-Seq_NPCs_Mouse0.84169861
157TCF7_22412390_ChIP-Seq_EML_Mouse0.84032558
158FOXA1_25552417_ChIP-Seq_VCAP_Human0.83973525
159GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80935196
160HIF1A_21447827_ChIP-Seq_MCF-7_Human0.80893689
161SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.80760879
162SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.80050594
163HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.80046035
164RXR_22108803_ChIP-Seq_LS180_Human0.78053858
165KDM2B_26808549_Chip-Seq_K562_Human0.77552175
166E2F1_17053090_ChIP-ChIP_MCF-7_Human0.76357501
167SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.75340401
168CDX2_20551321_ChIP-Seq_CACO-2_Human0.74854502
169* SOX11_22085726_ChIP-Seq_ESNs_Mouse0.73631101
170STAT3_18555785_ChIP-Seq_MESCs_Mouse0.73254849
171YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.72363248
172GATA1_19941827_ChIP-Seq_MEL_Mouse0.72329426
173FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.69709621

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting3.81580835
2MP0002876_abnormal_thyroid_physiology3.47985183
3MP0002139_abnormal_hepatobiliary_system3.33507121
4MP0003183_abnormal_peptide_metabolism3.29443544
5MP0003172_abnormal_lysosome_physiology3.09648662
6MP0003879_abnormal_hair_cell3.01528747
7MP0002089_abnormal_postnatal_growth/wei2.85034539
8MP0001800_abnormal_humoral_immune2.76218045
9MP0008877_abnormal_DNA_methylation2.72601574
10MP0003195_calcinosis2.68751296
11MP0005387_immune_system_phenotype2.64612920
12MP0001790_abnormal_immune_system2.64612920
13MP0002909_abnormal_adrenal_gland2.62608020
14MP0000681_abnormal_thyroid_gland2.62490070
15MP0003890_abnormal_embryonic-extraembry2.54779319
16MP0004859_abnormal_synaptic_plasticity2.50334345
17MP0005360_urolithiasis2.48230593
18MP0001293_anophthalmia2.34004772
19MP0002735_abnormal_chemical_nociception2.32786824
20MP0001666_abnormal_nutrient_absorption2.26146987
21MP0001501_abnormal_sleep_pattern2.19281680
22MP0004043_abnormal_pH_regulation2.18894174
23MP0000566_synostosis2.17504365
24MP0010329_abnormal_lipoprotein_level2.17412584
25MP0003635_abnormal_synaptic_transmissio2.16220377
26MP0002736_abnormal_nociception_after2.15275169
27MP0005408_hypopigmentation2.15101901
28MP0009780_abnormal_chondrocyte_physiolo2.11386841
29MP0009745_abnormal_behavioral_response2.10403759
30MP0002064_seizures2.07881938
31MP0003303_peritoneal_inflammation2.05423948
32MP0002938_white_spotting2.03225929
33MP0003122_maternal_imprinting2.02246519
34MP0002572_abnormal_emotion/affect_behav2.00334056
35MP0001835_abnormal_antigen_presentation1.97688106
36MP0004145_abnormal_muscle_electrophysio1.95518685
37MP0001968_abnormal_touch/_nociception1.90075307
38MP0006292_abnormal_olfactory_placode1.88544617
39MP0003121_genomic_imprinting1.87042188
40MP0002063_abnormal_learning/memory/cond1.84400662
41MP0005085_abnormal_gallbladder_physiolo1.79783540
42MP0002452_abnormal_antigen_presenting1.78630580
43MP0005646_abnormal_pituitary_gland1.78263863
44MP0001984_abnormal_olfaction1.78139391
45MP0002132_abnormal_respiratory_system1.75949936
46MP0000013_abnormal_adipose_tissue1.74952332
47MP0003880_abnormal_central_pattern1.72726180
48MP0009046_muscle_twitch1.71145610
49MP0003942_abnormal_urinary_system1.70505221
50MP0005645_abnormal_hypothalamus_physiol1.68666879
51MP0001915_intracranial_hemorrhage1.67065980
52MP0002067_abnormal_sensory_capabilities1.65789321
53MP0000639_abnormal_adrenal_gland1.62799521
54MP0002092_abnormal_eye_morphology1.58819362
55MP0000678_abnormal_parathyroid_gland1.56873206
56MP0005365_abnormal_bile_salt1.53642039
57MP0002697_abnormal_eye_size1.50459266
58MP0003567_abnormal_fetal_cardiomyocyte1.50007935
59MP0001286_abnormal_eye_development1.49348490
60MP0003115_abnormal_respiratory_system1.46534444
61MP0002272_abnormal_nervous_system1.45930968
62MP0001486_abnormal_startle_reflex1.41006808
63MP0003878_abnormal_ear_physiology1.39997129
64MP0005377_hearing/vestibular/ear_phenot1.39997129
65MP0001986_abnormal_taste_sensitivity1.37992931
66MP0002557_abnormal_social/conspecific_i1.37955521
67MP0000631_abnormal_neuroendocrine_gland1.37594860
68MP0005076_abnormal_cell_differentiation1.36668388
69MP0002138_abnormal_hepatobiliary_system1.35085474
70MP0003252_abnormal_bile_duct1.34202237
71MP0003123_paternal_imprinting1.33934809
72MP0003868_abnormal_feces_composition1.33552317
73MP0001765_abnormal_ion_homeostasis1.33390471
74MP0002822_catalepsy1.31720841
75MP0002398_abnormal_bone_marrow1.29304373
76MP0008569_lethality_at_weaning1.28953803
77MP0002420_abnormal_adaptive_immunity1.26457847
78MP0001440_abnormal_grooming_behavior1.25429313
79MP0000685_abnormal_immune_system1.22414290
80MP0005409_darkened_coat_color1.22337358
81MP0000689_abnormal_spleen_morphology1.21523741
82MP0003937_abnormal_limbs/digits/tail_de1.20725237
83MP0002933_joint_inflammation1.20664394
84MP0001963_abnormal_hearing_physiology1.20564601
85MP0004885_abnormal_endolymph1.18320476
86MP0001819_abnormal_immune_cell1.18287375
87MP0005451_abnormal_body_composition1.18106174
88MP0002009_preneoplasia1.17314903
89MP0004924_abnormal_behavior1.16709065
90MP0005386_behavior/neurological_phenoty1.16709065
91MP0005394_taste/olfaction_phenotype1.15745708
92MP0005499_abnormal_olfactory_system1.15745708
93MP0001529_abnormal_vocalization1.14034450
94MP0000534_abnormal_ureter_morphology1.12495564
95MP0008961_abnormal_basal_metabolism1.12370149
96MP0002723_abnormal_immune_serum1.12321958
97MP0001324_abnormal_eye_pigmentation1.10791485
98MP0000716_abnormal_immune_system1.10587158
99MP0005220_abnormal_exocrine_pancreas1.05539663
100MP0000026_abnormal_inner_ear1.04083960
101MP0005000_abnormal_immune_tolerance1.03932199
102MP0001661_extended_life_span1.03815619
103MP0002734_abnormal_mechanical_nocicepti1.00644651
104MP0004742_abnormal_vestibular_system0.99461401
105MP0002733_abnormal_thermal_nociception0.99117674
106MP0002249_abnormal_larynx_morphology0.96928859
107MP0003861_abnormal_nervous_system0.95952532
108MP0003938_abnormal_ear_development0.93816818
109MP0000003_abnormal_adipose_tissue0.93149052
110MP0002184_abnormal_innervation0.92988016
111MP0003950_abnormal_plasma_membrane0.92940283
112MP0005671_abnormal_response_to0.90084176
113MP0000569_abnormal_digit_pigmentation0.89866399
114MP0002233_abnormal_nose_morphology0.89714298
115MP0003646_muscle_fatigue0.89704128
116MP0009115_abnormal_fat_cell0.89159544
117MP0003943_abnormal_hepatobiliary_system0.88727248
118MP0001188_hyperpigmentation0.88585806
119MP0005167_abnormal_blood-brain_barrier0.88170475
120MP0004264_abnormal_extraembryonic_tissu0.88092921
121MP0003300_gastrointestinal_ulcer0.87322284
122MP0008874_decreased_physiological_sensi0.86670465
123MP0001879_abnormal_lymphatic_vessel0.86470910
124MP0000609_abnormal_liver_physiology0.86199622
125MP0001485_abnormal_pinna_reflex0.85796781
126MP0002932_abnormal_joint_morphology0.85668607
127MP0005391_vision/eye_phenotype0.85120946
128MP0001756_abnormal_urination0.83893904
129MP0001730_embryonic_growth_arrest0.82223540
130MP0003136_yellow_coat_color0.82029870
131MP0000778_abnormal_nervous_system0.81956280
132MP0004233_abnormal_muscle_weight0.81864354
133MP0009384_cardiac_valve_regurgitation0.81713108
134MP0003984_embryonic_growth_retardation0.81519698
135MP0002429_abnormal_blood_cell0.81304525
136MP0008057_abnormal_DNA_replication0.81266148
137MP0001502_abnormal_circadian_rhythm0.81167985
138MP0002722_abnormal_immune_system0.80607029
139MP0002136_abnormal_kidney_physiology0.80495233
140MP0000371_diluted_coat_color0.78143909
141MP0001970_abnormal_pain_threshold0.77753518
142MP0002088_abnormal_embryonic_growth/wei0.75889884
143MP0002109_abnormal_limb_morphology0.75355199
144MP0001697_abnormal_embryo_size0.74819266
145MP0003941_abnormal_skin_development0.74174309
146MP0002928_abnormal_bile_duct0.74127655
147MP0000703_abnormal_thymus_morphology0.73788092
148MP0005195_abnormal_posterior_eye0.73448038
149MP0008789_abnormal_olfactory_epithelium0.72187677
150MP0004808_abnormal_hematopoietic_stem0.68396828
151MP0002653_abnormal_ependyma_morphology0.68204092
152MP0005310_abnormal_salivary_gland0.68141138
153MP0002066_abnormal_motor_capabilities/c0.67811061
154MP0001672_abnormal_embryogenesis/_devel0.67166636
155MP0005380_embryogenesis_phenotype0.67166636
156MP0002152_abnormal_brain_morphology0.66977510
157MP0010630_abnormal_cardiac_muscle0.66850192
158MP0003221_abnormal_cardiomyocyte_apopto0.66677469
159MP0000598_abnormal_liver_morphology0.65777221
160MP0003632_abnormal_nervous_system0.65659956
161MP0002116_abnormal_craniofacial_bone0.64553265
162MP0001919_abnormal_reproductive_system0.63416429
163MP0003953_abnormal_hormone_level0.63002828
164MP0006276_abnormal_autonomic_nervous0.62826978
165MP0002127_abnormal_cardiovascular_syste0.62539941
166MP0002118_abnormal_lipid_homeostasis0.61634870
167MP0001270_distended_abdomen0.61368482
168MP0005332_abnormal_amino_acid0.60916146
169MP0002166_altered_tumor_susceptibility0.59815740
170MP0004142_abnormal_muscle_tone0.59193150
171MP0000955_abnormal_spinal_cord0.59003893
172MP0002086_abnormal_extraembryonic_tissu0.58714977
173MP0002135_abnormal_kidney_morphology0.56773755

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)7.82837569
2Deep venous thrombosis (HP:0002625)7.03212613
3Gastrointestinal stroma tumor (HP:0100723)6.24662314
4Papilloma (HP:0012740)5.08629113
5Verrucae (HP:0200043)5.08629113
6Recurrent sinusitis (HP:0011108)4.54760486
7Cellulitis (HP:0100658)4.52915650
8Recurrent bronchitis (HP:0002837)4.38791259
9Irregular epiphyses (HP:0010582)4.33480562
10Prolonged partial thromboplastin time (HP:0003645)4.28733194
11Broad alveolar ridges (HP:0000187)4.28143965
12Acanthocytosis (HP:0001927)4.21609810
13Small epiphyses (HP:0010585)4.02599558
14Colitis (HP:0002583)3.84808228
15B lymphocytopenia (HP:0010976)3.84307482
16Abnormality of B cell number (HP:0010975)3.84307482
17Focal motor seizures (HP:0011153)3.80489586
18Hepatoblastoma (HP:0002884)3.77193606
19Thyroid-stimulating hormone excess (HP:0002925)3.73491264
20Epiphyseal dysplasia (HP:0002656)3.72550489
21Hypobetalipoproteinemia (HP:0003563)3.71777109
22Chronic sinusitis (HP:0011109)3.71276060
23Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.70857950
24Abnormal tarsal ossification (HP:0008369)3.65413205
25Broad palm (HP:0001169)3.64876957
26Lymphopenia (HP:0001888)3.62399628
27Joint hemorrhage (HP:0005261)3.59716124
28Flat acetabular roof (HP:0003180)3.57281747
29Vertebral arch anomaly (HP:0008438)3.50895920
30Abnormality of the pubic bones (HP:0003172)3.41780908
31Hypoplasia of the capital femoral epiphysis (HP:0003090)3.38876681
32Abnormality of cells of the lymphoid lineage (HP:0012140)3.36193942
33Vitreoretinal degeneration (HP:0000655)3.33295229
34Atonic seizures (HP:0010819)3.27897971
35Panhypogammaglobulinemia (HP:0003139)3.18487881
36Emphysema (HP:0002097)3.18067331
37Inflammation of the large intestine (HP:0002037)3.17015419
38Supernumerary ribs (HP:0005815)3.15335934
39Increased circulating renin level (HP:0000848)3.13658872
40Thyroiditis (HP:0100646)3.11639843
41Hyperthyroidism (HP:0000836)3.09331459
42Meningitis (HP:0001287)3.08059658
43Pancreatic islet-cell hyperplasia (HP:0004510)3.07860536
44Epileptic encephalopathy (HP:0200134)3.06811137
45IgM deficiency (HP:0002850)3.05654694
46Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.05272075
47Absent epiphyses (HP:0010577)3.05272075
48Gastrointestinal inflammation (HP:0004386)3.02010147
49Abnormality of the common coagulation pathway (HP:0010990)2.99376665
50Goiter (HP:0000853)2.98042125
51Mitral stenosis (HP:0001718)2.97216284
52Hypercholesterolemia (HP:0003124)2.97193392
53Febrile seizures (HP:0002373)2.96140491
54Decreased circulating renin level (HP:0003351)2.93027763
55Recurrent otitis media (HP:0000403)2.87806852
56Abnormality of the lumbar spine (HP:0100712)2.86156714
57Osteomyelitis (HP:0002754)2.85040393
58Recurrent pneumonia (HP:0006532)2.83334699
59Abnormal hair whorl (HP:0010721)2.81451882
60Abnormality of renin-angiotensin system (HP:0000847)2.80893090
61Abnormality of the wing of the ilium (HP:0011867)2.75937343
62Abnormality of the intervertebral disk (HP:0005108)2.75379309
63Renal salt wasting (HP:0000127)2.74127470
64Enlarged penis (HP:0000040)2.73601807
65Diastasis recti (HP:0001540)2.71284994
66Supernumerary bones of the axial skeleton (HP:0009144)2.70173624
67Abnormality of carpal bone ossification (HP:0006257)2.68833310
68Barrel-shaped chest (HP:0001552)2.67438262
69Restrictive lung disease (HP:0002091)2.61134656
70Recurrent viral infections (HP:0004429)2.59585830
71Bronchitis (HP:0012387)2.58991038
72Supernumerary spleens (HP:0009799)2.57360424
73Trigonocephaly (HP:0000243)2.55249530
74Hyperventilation (HP:0002883)2.52148075
75Sepsis (HP:0100806)2.51310257
76Deep palmar crease (HP:0006191)2.49967480
77Irregular vertebral endplates (HP:0003301)2.48460398
78Hyperaldosteronism (HP:0000859)2.48349079
79Aqueductal stenosis (HP:0002410)2.48203499
80Abnormality of the nasal septum (HP:0000419)2.48062016
81Myelomeningocele (HP:0002475)2.46781986
82Anophthalmia (HP:0000528)2.43625569
83Absence seizures (HP:0002121)2.43317466
84Complement deficiency (HP:0004431)2.40737929
85Abnormal foot bone ossification (HP:0010675)2.39331681
86Recurrent lower respiratory tract infections (HP:0002783)2.39145589
87Tetany (HP:0001281)2.33895817
88Hypophosphatemic rickets (HP:0004912)2.33060330
89Glomerulonephritis (HP:0000099)2.31342443
90Abnormality of the peritoneum (HP:0002585)2.29402650
91Flattened epiphyses (HP:0003071)2.29291652
92Abnormal hand bone ossification (HP:0010660)2.26502588
93Wide nose (HP:0000445)2.25404903
94Alacrima (HP:0000522)2.24913969
95Widely spaced teeth (HP:0000687)2.22017989
96Hemorrhage of the eye (HP:0011885)2.21606581
97Bronchomalacia (HP:0002780)2.17208204
98Cupped ribs (HP:0000887)2.17185372
99Hypoplastic pelvis (HP:0008839)2.17163168
100Abnormal ossification of hand bones (HP:0005921)2.15152892
101Abnormality of the fingertips (HP:0001211)2.14187609
102Enlarged kidneys (HP:0000105)2.14157614
103Aplasia/Hypoplasia of the sternum (HP:0006714)2.13945750
104Absent eyebrow (HP:0002223)2.11904906
105Dehydration (HP:0001944)2.10169628
106Limited elbow extension (HP:0001377)2.09973857
107Heterotopia (HP:0002282)2.09371597
108Hypolipoproteinemia (HP:0010981)2.08980553
109Vasculitis (HP:0002633)2.06968651
110IgA deficiency (HP:0002720)2.06430182
111Broad-based gait (HP:0002136)2.04371613
112Menorrhagia (HP:0000132)2.03977153
113IgG deficiency (HP:0004315)2.02835222
114Dialeptic seizures (HP:0011146)2.02669441
115Abnormality of cochlea (HP:0000375)2.02399876
116Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.00108738
117Generalized hypotonia (HP:0001290)1.99549274
118Hyperphosphatemia (HP:0002905)1.98540083
119Abnormal delayed hypersensitivity skin test (HP:0002963)1.97967292
120Spontaneous abortion (HP:0005268)1.96844242
121Papillary thyroid carcinoma (HP:0002895)1.96441817
122Abnormality of the labia minora (HP:0012880)1.95334232
123Rectal prolapse (HP:0002035)1.95205928
124Protruding tongue (HP:0010808)1.92828997
125Epidermoid cyst (HP:0200040)1.90965321
126Hypothermia (HP:0002045)1.90383595
127Viral hepatitis (HP:0006562)1.90168896
128Focal seizures (HP:0007359)1.89889576
129Abnormality of the pancreatic islet cells (HP:0006476)1.89785533
130Abnormality of endocrine pancreas physiology (HP:0012093)1.89785533
131Arthropathy (HP:0003040)1.88638086
132Excessive salivation (HP:0003781)1.88578574
133Drooling (HP:0002307)1.88578574
134Abnormality of the vertebral endplates (HP:0005106)1.87441626
135Prenatal maternal abnormality (HP:0002686)1.85429358
136Ulnar bowing (HP:0003031)1.84703702
137Hyperglycinemia (HP:0002154)1.83305989
138Macroorchidism (HP:0000053)1.83007158
139Nephroblastoma (Wilms tumor) (HP:0002667)1.82764892
140Vaginal fistula (HP:0004320)1.82165252
141Potter facies (HP:0002009)1.82043669
142Facial shape deformation (HP:0011334)1.82043669
143Intrahepatic cholestasis (HP:0001406)1.81698011
144Hypoplasia of the uterus (HP:0000013)1.81341699
145Flared iliac wings (HP:0002869)1.81002116
146Capillary hemangiomas (HP:0005306)1.80527587
147Recurrent gram-negative bacterial infections (HP:0005420)1.80219612
148Hypoplasia of the thymus (HP:0000778)1.79659006
149Resting tremor (HP:0002322)1.79126265
150Abnormality of the lacrimal duct (HP:0011481)1.77453031
151Facial hemangioma (HP:0000329)1.74842239
152Cubitus valgus (HP:0002967)1.72751470
153Scrotal hypoplasia (HP:0000046)1.72549958
154Oligomenorrhea (HP:0000876)1.72144470
155Inability to walk (HP:0002540)1.72110358
156Embryonal renal neoplasm (HP:0011794)1.71067040
157Hip dysplasia (HP:0001385)1.70100151
158Thrombophlebitis (HP:0004418)1.68744873
159Hypoventilation (HP:0002791)1.67640634
160Leukopenia (HP:0001882)1.67085470
161Neoplasm of the heart (HP:0100544)1.66581577
162Bicornuate uterus (HP:0000813)1.66435573
163Dislocated radial head (HP:0003083)1.64984270
164Poikilocytosis (HP:0004447)1.64311483
165Metaphyseal irregularity (HP:0003025)1.64093764
166Purpura (HP:0000979)1.63479255
167Xanthomatosis (HP:0000991)1.63266336
168Adrenal overactivity (HP:0002717)1.63106329
169Orthostatic hypotension (HP:0001278)1.62888049
170Short femoral neck (HP:0100864)1.62580066
171Midline defect of the nose (HP:0004122)1.60592379
172Abnormality of the alveolar ridges (HP:0006477)1.60533410
173Anal stenosis (HP:0002025)1.59711952
174Truncal obesity (HP:0001956)1.59263409
175External ear malformation (HP:0008572)1.58961371
176Arnold-Chiari malformation (HP:0002308)1.57994606
177Abnormality of salivation (HP:0100755)1.57327970
178Obsessive-compulsive behavior (HP:0000722)1.57159508
179Testicular neoplasm (HP:0010788)1.56524167
180Narrow nasal bridge (HP:0000446)1.56229852
181Hyperpituitarism (HP:0010514)1.54528571
182Amblyopia (HP:0000646)1.53035010
183Blue irides (HP:0000635)1.52814650

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K104.74981168
2CASK3.97310423
3PKN23.82279287
4FGFR43.61562556
5MAP4K13.45289861
6GRK63.29103586
7EPHA43.04111558
8WNK32.85588860
9ICK2.85027551
10MAP3K42.82305133
11TRIB32.59463647
12AKT32.53162279
13RIPK42.43304649
14MAP2K72.42726860
15SIK32.33028209
16CCNB12.27608003
17FRK2.19279152
18CDK192.08683142
19NTRK31.96739271
20NEK11.96533722
21NEK21.94206729
22ERN11.89848106
23SYK1.81534309
24MAP3K111.72184972
25DAPK21.71806068
26SIK21.65742329
27TYRO31.61650665
28CSF1R1.50346291
29FGFR11.46875613
30BTK1.39575395
31DAPK11.34984441
32WNK11.29894616
33DYRK1B1.28666208
34RET1.24856680
35YES11.24845467
36EIF2AK31.24233919
37SGK21.23257630
38OXSR11.22291712
39MAPK71.18765954
40MAP3K121.17113684
41TSSK61.16798612
42MAPK131.15148406
43SGK31.13449981
44CAMK1D1.12352096
45FLT31.11167842
46LYN1.09930097
47PIK3CG1.09851131
48FGR1.09794555
49WNK41.07664939
50LATS11.07292949
51MAP2K41.05927902
52MAP2K11.05696959
53OBSCN1.03636288
54PLK21.02375128
55CDK31.01584931
56CDC42BPA0.99694762
57MAPK110.96373741
58IRAK20.95394076
59MAP3K70.92154276
60PRPF4B0.91619493
61BRSK20.90618587
62FGFR20.90537859
63MST40.89227703
64LRRK20.88079252
65PDK40.86248776
66PDK30.86248776
67NTRK20.84817898
68MELK0.84500365
69BRD40.84442104
70TNK20.82480030
71DYRK1A0.82284180
72PIK3CA0.81931115
73FES0.81589601
74UHMK10.80719631
75CAMK40.79945977
76SGK4940.79297416
77SGK2230.79297416
78BRSK10.78617428
79MAP3K90.76675038
80NLK0.76208536
81KSR10.75464046
82IRAK40.73265323
83CDK90.72884207
84TYK20.70656113
85MARK10.70530157
86TLK10.70020719
87JAK10.69661181
88SGK10.65595608
89ERBB30.65565323
90RIPK10.65093985
91PRKCH0.64840270
92MAPK150.64601938
93PRKCG0.63223117
94MAPK120.61640282
95MKNK20.59842479
96ACVR1B0.58931051
97DMPK0.58191690
98MAPKAPK50.57392173
99PAK30.56227609
100SIK10.56163587
101SMG10.55092408
102GRK10.53957382
103RPS6KB10.53747460
104MATK0.53542628
105PDK10.53211531
106CDK50.52155722
107MAP3K130.51214308
108CDK80.51201596
109PRKAA10.50229540
110ITK0.50203708
111PRKAA20.50130248
112CSK0.49983436
113CAMK1G0.48894873
114PRKCZ0.48011930
115MINK10.47477785
116MAP3K20.47113546
117BLK0.46762667
118PRKCI0.46542255
119STK100.46304119
120FYN0.46279672
121PDGFRA0.46160831
122HCK0.44140014
123MARK20.43778745
124ATR0.43190479
125INSRR0.42660807
126CDK40.42315421
127MARK30.42312329
128BMPR1B0.41480495
129MAP2K20.41471624
130HIPK20.40089982
131CHEK10.40059840
132EEF2K0.39955948
133STK38L0.39382538
134ATM0.38460122
135CSNK1E0.36597260
136DYRK20.35316250
137CDK10.34129029
138CAMKK10.33841380
139CDK120.33471746
140PRKCQ0.33227746
141KSR20.33085393
142MAP3K140.31096502
143MAPK100.30966327
144CAMK10.30617824
145CDK70.29810978
146DYRK30.29584487
147CDK20.29546932
148PDPK10.29466014
149INSR0.29245220
150FGFR30.28164433
151STK40.27802220
152LCK0.27332695
153MAPK40.27040058
154EIF2AK10.26371362

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046103.99612269
2B cell receptor signaling pathway_Homo sapiens_hsa046623.95092569
3Primary immunodeficiency_Homo sapiens_hsa053403.57348150
4Steroid biosynthesis_Homo sapiens_hsa001003.53500795
5Collecting duct acid secretion_Homo sapiens_hsa049663.11234255
6Staphylococcus aureus infection_Homo sapiens_hsa051503.03467098
7Synaptic vesicle cycle_Homo sapiens_hsa047212.91098432
8Nicotine addiction_Homo sapiens_hsa050332.52525053
9Fat digestion and absorption_Homo sapiens_hsa049752.33080068
10Aldosterone synthesis and secretion_Homo sapiens_hsa049252.30972794
11Fatty acid biosynthesis_Homo sapiens_hsa000612.26150773
12Vibrio cholerae infection_Homo sapiens_hsa051101.97426531
13Morphine addiction_Homo sapiens_hsa050321.96240120
14Lysine degradation_Homo sapiens_hsa003101.88975261
15Autoimmune thyroid disease_Homo sapiens_hsa053201.88118115
16Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.87576384
17Circadian entrainment_Homo sapiens_hsa047131.86221214
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.85871397
19Long-term potentiation_Homo sapiens_hsa047201.76738741
20Olfactory transduction_Homo sapiens_hsa047401.71245160
21Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.68203802
22Amphetamine addiction_Homo sapiens_hsa050311.64032575
23Dopaminergic synapse_Homo sapiens_hsa047281.56928634
24N-Glycan biosynthesis_Homo sapiens_hsa005101.55299822
25Thyroid hormone synthesis_Homo sapiens_hsa049181.53773297
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.53302784
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.48501122
28GABAergic synapse_Homo sapiens_hsa047271.48139763
29Vitamin digestion and absorption_Homo sapiens_hsa049771.48063588
30Basal cell carcinoma_Homo sapiens_hsa052171.46366155
31Hematopoietic cell lineage_Homo sapiens_hsa046401.46012142
32Insulin secretion_Homo sapiens_hsa049111.43601599
33Renin secretion_Homo sapiens_hsa049241.41121323
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.35798591
35Glutamatergic synapse_Homo sapiens_hsa047241.34521583
36Long-term depression_Homo sapiens_hsa047301.30585965
37Gastric acid secretion_Homo sapiens_hsa049711.29019118
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.26812777
39Salivary secretion_Homo sapiens_hsa049701.24232957
40Notch signaling pathway_Homo sapiens_hsa043301.23587634
41Taste transduction_Homo sapiens_hsa047421.22924643
42Hedgehog signaling pathway_Homo sapiens_hsa043401.20834234
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.17598973
44Fatty acid metabolism_Homo sapiens_hsa012121.17007203
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.16120568
46Type II diabetes mellitus_Homo sapiens_hsa049301.14806995
47GnRH signaling pathway_Homo sapiens_hsa049121.14119284
48Maturity onset diabetes of the young_Homo sapiens_hsa049501.13918526
49mRNA surveillance pathway_Homo sapiens_hsa030151.10848506
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.10836164
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.09788489
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.09748709
53Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.08748648
54Alcoholism_Homo sapiens_hsa050341.07422981
55Asthma_Homo sapiens_hsa053101.05784790
56Rheumatoid arthritis_Homo sapiens_hsa053231.05663698
57Fatty acid degradation_Homo sapiens_hsa000711.04085208
58ABC transporters_Homo sapiens_hsa020101.02435177
59PPAR signaling pathway_Homo sapiens_hsa033201.02377579
60Propanoate metabolism_Homo sapiens_hsa006400.98436220
61Oxytocin signaling pathway_Homo sapiens_hsa049210.96576086
62Calcium signaling pathway_Homo sapiens_hsa040200.96224977
63Hippo signaling pathway_Homo sapiens_hsa043900.93980251
64Thyroid cancer_Homo sapiens_hsa052160.93923147
65Serotonergic synapse_Homo sapiens_hsa047260.93169624
66Non-homologous end-joining_Homo sapiens_hsa034500.92722237
67Inositol phosphate metabolism_Homo sapiens_hsa005620.92293941
68Leishmaniasis_Homo sapiens_hsa051400.92190548
69Type I diabetes mellitus_Homo sapiens_hsa049400.91557188
70Ovarian steroidogenesis_Homo sapiens_hsa049130.91459856
71Chronic myeloid leukemia_Homo sapiens_hsa052200.91354961
72Prostate cancer_Homo sapiens_hsa052150.90821825
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89929447
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87755936
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87571098
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87204118
77MAPK signaling pathway_Homo sapiens_hsa040100.86698020
78Adherens junction_Homo sapiens_hsa045200.86209050
79Cocaine addiction_Homo sapiens_hsa050300.85131421
80Allograft rejection_Homo sapiens_hsa053300.84939206
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84812159
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84148744
83Cholinergic synapse_Homo sapiens_hsa047250.83396974
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.83291751
85Non-small cell lung cancer_Homo sapiens_hsa052230.81994529
86Glioma_Homo sapiens_hsa052140.81763550
87cAMP signaling pathway_Homo sapiens_hsa040240.81738761
88Insulin resistance_Homo sapiens_hsa049310.81652534
89Spliceosome_Homo sapiens_hsa030400.81600228
90Tuberculosis_Homo sapiens_hsa051520.80556915
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79905821
92Chemokine signaling pathway_Homo sapiens_hsa040620.79324338
93ErbB signaling pathway_Homo sapiens_hsa040120.78823276
94Glucagon signaling pathway_Homo sapiens_hsa049220.78170891
95Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.76818478
96HIF-1 signaling pathway_Homo sapiens_hsa040660.76661862
97Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75823993
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75745538
99Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75597184
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.75547245
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.75136581
102Other glycan degradation_Homo sapiens_hsa005110.74630044
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.74543390
104VEGF signaling pathway_Homo sapiens_hsa043700.73756290
105NF-kappa B signaling pathway_Homo sapiens_hsa040640.73681984
106Estrogen signaling pathway_Homo sapiens_hsa049150.73199067
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72690962
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72362228
109Osteoclast differentiation_Homo sapiens_hsa043800.72021859
110Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.71232532
111MicroRNAs in cancer_Homo sapiens_hsa052060.70801398
112Graft-versus-host disease_Homo sapiens_hsa053320.70354598
113Arginine biosynthesis_Homo sapiens_hsa002200.69641756
114Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69409120
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68628069
116Pyruvate metabolism_Homo sapiens_hsa006200.66866030
117Insulin signaling pathway_Homo sapiens_hsa049100.65956820
118Colorectal cancer_Homo sapiens_hsa052100.65916873
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65587899
120Systemic lupus erythematosus_Homo sapiens_hsa053220.65313793
121Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63904596
122Glycerolipid metabolism_Homo sapiens_hsa005610.62671167
123Toxoplasmosis_Homo sapiens_hsa051450.62640788
124T cell receptor signaling pathway_Homo sapiens_hsa046600.61913521
125Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61386428
126Small cell lung cancer_Homo sapiens_hsa052220.60844207
127Phagosome_Homo sapiens_hsa041450.58944993
128TGF-beta signaling pathway_Homo sapiens_hsa043500.56873489
129Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56121828
130Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55774071
131FoxO signaling pathway_Homo sapiens_hsa040680.54353532
132Starch and sucrose metabolism_Homo sapiens_hsa005000.53961559
133Pancreatic cancer_Homo sapiens_hsa052120.53742166
134Adipocytokine signaling pathway_Homo sapiens_hsa049200.53349703
135Axon guidance_Homo sapiens_hsa043600.53158427
136Choline metabolism in cancer_Homo sapiens_hsa052310.52882349
137Epstein-Barr virus infection_Homo sapiens_hsa051690.51882180
138Vascular smooth muscle contraction_Homo sapiens_hsa042700.49394290
139mTOR signaling pathway_Homo sapiens_hsa041500.47298822
140Histidine metabolism_Homo sapiens_hsa003400.46106785
141Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45638012
142Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45352380
143Prolactin signaling pathway_Homo sapiens_hsa049170.44784842
144Renin-angiotensin system_Homo sapiens_hsa046140.44383694
145Melanoma_Homo sapiens_hsa052180.43044640
146AMPK signaling pathway_Homo sapiens_hsa041520.41909298
147Wnt signaling pathway_Homo sapiens_hsa043100.41641244
148Melanogenesis_Homo sapiens_hsa049160.41455300
149Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40648725
150HTLV-I infection_Homo sapiens_hsa051660.40615472
151Viral carcinogenesis_Homo sapiens_hsa052030.40289446
152Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40181831
153Renal cell carcinoma_Homo sapiens_hsa052110.39261610
154Antigen processing and presentation_Homo sapiens_hsa046120.38997934
155Acute myeloid leukemia_Homo sapiens_hsa052210.37922872
156Ras signaling pathway_Homo sapiens_hsa040140.37174053
157Phospholipase D signaling pathway_Homo sapiens_hsa040720.36697984
158Hepatitis B_Homo sapiens_hsa051610.35578681
159Endometrial cancer_Homo sapiens_hsa052130.35306001
160Hepatitis C_Homo sapiens_hsa051600.33739082
161Platelet activation_Homo sapiens_hsa046110.32652248
162Steroid hormone biosynthesis_Homo sapiens_hsa001400.32545629

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